thioacetamide

Summary

Summary: A crystalline compound used as a laboratory reagent in place of HYDROGEN SULFIDE. It is a potent hepatocarcinogen.

Top Publications

  1. Balkan J, Dogru Abbasoglu S, Kanbagli O, Cevikbas U, Aykac Toker G, Uysal M. Taurine has a protective effect against thioacetamide-induced liver cirrhosis by decreasing oxidative stress. Hum Exp Toxicol. 2001;20:251-4 pubmed
    b>Thioacetamide (TAA) administration (0.3 g/l of tap water for a period of 3 months) to rats resulted in hepatic cirrhosis as assessed by biochemical and histopathological findings...
  2. Harputluoglu M, Demirel U, Gul M, Temel I, Gursoy S, Selcuk E, et al. Effects of rifaximin on bacterial translocation in thioacetamide-induced liver injury in rats. Inflammation. 2012;35:1512-7 pubmed publisher
    ..The aim of the present study was to investigate the effects of RIF on BT frequency in thioacetamide (TAA)-induced liver injury. Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days...
  3. Lee J, Shin K, Lee M, Kim E, Han S, Han M, et al. Role of metabolism by flavin-containing monooxygenase in thioacetamide-induced immunosuppression. Toxicol Lett. 2003;136:163-72 pubmed
    b>Thioacetamide has been known to cause immune suppression. The object of the present study is to investigate the role of metabolic activation by flavin-containing monooxygenases (FMO) in thioacetamide-induced immune response...
  4. Geng J, Peng W, Huang Y, Fan H, Li S. Ginsenoside-Rg1 from Panax notoginseng prevents hepatic fibrosis induced by thioacetamide in rats. Eur J Pharmacol. 2010;634:162-9 pubmed publisher
    ..analysis revealed that ginsenoside-Rg1 significantly improved the extent of liver fibrosis in rats induced by thioacetamide. Ginsenoside-Rg1 markedly suppressed the serum levels of fibrotic markers and hepatic hydroxyproline content ..
  5. Fernández Martínez A, Callejas N, Casado M, Bosca L, Martín Sanz P. Thioacetamide-induced liver regeneration involves the expression of cyclooxygenase 2 and nitric oxide synthase 2 in hepatocytes. J Hepatol. 2004;40:963-70 pubmed
    A regeneration process intended to restore organ function follows liver hepatotoxicity induced by a necrogenic dose of thioacetamide (TAM).
  6. Traber P, Chou H, Zomer E, Hong F, Klyosov A, Fiel M, et al. Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease. PLoS ONE. 2013;8:e75361 pubmed publisher
    ..Fibrosis was induced in rats by intraperitoneal injections with thioacetamide (TAA) and groups were treated with vehicle, GR-MD-02 (galactoarabino-rhamnogalaturonan) or GM-CT-01 (..
  7. Salama S, Abdulla M, Alrashdi A, Ismail S, Alkiyumi S, Golbabapour S. Hepatoprotective effect of ethanolic extract of Curcuma longa on thioacetamide induced liver cirrhosis in rats. BMC Complement Altern Med. 2013;13:56 pubmed publisher
    ..Thus, this study evaluated mechanisms of the hepatoprotective activity of Curcuma longa rhizome ethanolic extract (CLRE) on thioacetamide-induced liver cirrhosis in rats.
  8. Kucera O, Lotkova H, Staňková P, Podhola M, Rousar T, Mezera V, et al. Is rat liver affected by non-alcoholic steatosis more susceptible to the acute toxic effect of thioacetamide?. Int J Exp Pathol. 2011;92:281-9 pubmed publisher
    ..of this project was to test whether hepatic steatosis sensitizes rat liver to acute toxic injury induced by thioacetamide (TAA)...
  9. Li J, Chen B, Lai D, Jia Z, Andersson R, Zhang B, et al. Soy isoflavone delays the progression of thioacetamide-induced liver fibrosis in rats. Scand J Gastroenterol. 2011;46:341-9 pubmed publisher
    Our aim was to investigate the effect of soy isoflavone (SI) on liver fibrosis in a thioacetamide (TAA)-induced rat model.

Scientific Experts

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Publications62

  1. Kang J, Wanibuchi H, Morimura K, Wongpoomchai R, Chusiri Y, Gonzalez F, et al. Role of CYP2E1 in thioacetamide-induced mouse hepatotoxicity. Toxicol Appl Pharmacol. 2008;228:295-300 pubmed publisher
    Previous experiments showed that treatment of mice and rats with thioacetamide (TAA) induced liver cell damage, fibrosis and/or cirrhosis, associated with increased oxidative stress and activation of hepatic stellate cells...
  2. Amali A, Rekha R, Lin C, Wang W, Gong H, Her G, et al. Thioacetamide induced liver damage in zebrafish embryo as a disease model for steatohepatitis. J Biomed Sci. 2006;13:225-32 pubmed
    ..We induced steatohepatitis in zebrafish embryos using thioacetamide (TAA)...
  3. Hernandez R, Martinez Lara E, Del Moral M, Blanco S, Cañuelo A, Siles E, et al. Upregulation of endothelial nitric oxide synthase maintains nitric oxide production in the cerebellum of thioacetamide cirrhotic rats. Neuroscience. 2004;126:879-87 pubmed
    ..complexes, and the nitric oxide (NO) production in the cerebellum of rats with cirrhosis induced by thioacetamide (TAA)...
  4. Xu H, Shi B, Lu X, Liang F, Jin X, Wu T, et al. Vascular endothelial growth factor attenuates hepatic sinusoidal capillarization in thioacetamide-induced cirrhotic rats. World J Gastroenterol. 2008;14:2349-57 pubmed
    ..To investigate the effect of vascular endothelial growth factor (VEGF) transfection on hepatic sinusoidal capillarization...
  5. Ramaiah S, Apte U, Mehendale H. Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats. Drug Metab Dispos. 2001;29:1088-95 pubmed
    Earlier studies have shown highly exaggerated mechanism-based liver injury of thioacetamide (TA) in rats following moderate diet restriction (DR) and in diabetes...
  6. Shao C, Chen S, Dong T, Chai H, Yu Y, Deng L, et al. Transplantation of bone marrow-derived mesenchymal stem cells after regional hepatic irradiation ameliorates thioacetamide-induced liver fibrosis in rats. J Surg Res. 2014;186:408-16 pubmed publisher
    ..In this study, we investigate the effects of HIR on transplanted BM-MSCs in cirrhotic rats and the underlying mechanism by which mesenchymal stem cells (MSCs) relieve liver fibrosis...
  7. Esmat A, Said M, Soliman A, El Masry K, Badiea E. Bioactive compounds, antioxidant potential, and hepatoprotective activity of sea cucumber (Holothuria atra) against thioacetamide intoxication in rats. Nutrition. 2013;29:258-67 pubmed publisher
    ..active phenolic compounds in the mixed extract of sea cucumber (Holothuria atra) body wall by high-performance liquid chromatography and an assessment of its hepatoprotective activity against thioacetamide-induced liver fibrosis in rats.
  8. de David C, Rodrigues G, Bona S, Meurer L, Gonzalez Gallego J, Tuñón M, et al. Role of quercetin in preventing thioacetamide-induced liver injury in rats. Toxicol Pathol. 2011;39:949-57 pubmed publisher
    In hepatic toxicity induced in rats by two injections of thioacetamide (TAA, 350 mg/kg with an interval of 8 hr), the action of quercetin was investigated...
  9. Gu K, Zhao J, Ren Z, Ma N, Lai S, Wang J, et al. A natural process of cirrhosis resolution and deceleration of liver regeneration after thioacetamide withdrawal in a rat model. Mol Biol Rep. 2011;38:1687-96 pubmed publisher
    Characteristics of thioacetamide (TAA)-induced liver cirrhosis in rat was observed for 120 days after TAA withdrawal as part of the radiobiological study of partial liver irradiation on TAA-induced cirrhotic rats...
  10. Kishioka T, Iida C, Fujii K, Nagae R, Onishi Y, Ichi I, et al. Effect of dimethyl sulphoxide on oxidative stress, activation of mitogen activated protein kinase and necrosis caused by thioacetamide in the rat liver. Eur J Pharmacol. 2007;564:190-5 pubmed
    b>Thioacetamide (400 mg/kg body weight, i.p.) was administered to rats...
  11. Harputluoglu M, Demirel U, Ciralik H, Temel I, Firat S, Ara C, et al. Protective effects of Gingko biloba on thioacetamide-induced fulminant hepatic failure in rats. Hum Exp Toxicol. 2006;25:705-13 pubmed
    ..We investigated the protective effects of GB on thioacetamide (TAA)-induced fulminant hepatic failure in rats...
  12. Hori Y, Sato S, Yamate J, Kurasaki M, Nishihira J, Hosokawa T, et al. Immunohistochemical study of macrophage migration inhibitory factor in rat liver fibrosis induced by thioacetamide. Eur J Histochem. 2003;47:317-24 pubmed
    ..Male Wistar rats received thioacetamide (TA) injections (200 mg/kg, i.p.) for 1 or 6 weeks...
  13. Novosyadlyy R, Dargel R, Scharf J. Expression of insulin-like growth factor-I and insulin-like growth factor binding proteins during thioacetamide-induced liver cirrhosis in rats. Growth Horm IGF Res. 2005;15:313-23 pubmed
    ..In liver cirrhosis the IGF axis is severely disturbed, and these alterations are associated with reduced IGF-I, IGFBP-3 but elevated IGFBP-1 serum levels...
  14. Karantonis H, Gribilas G, Stamoulis I, Giaginis C, Spiliopoulou C, Kouraklis G, et al. Platelet-activating factor involvement in thioacetamide-induced experimental liver fibrosis and cirrhosis. Dig Dis Sci. 2010;55:276-84 pubmed publisher
    ..Liver fibrosis was induced in adult male Wistar rats by administration of thioacetamide (TAA) in drinking water (300 mg/l) for three months...
  15. Huang H, Wang S, Lee F, Chan C, Chang F, Lin H, et al. Simvastatin for rats with thioacetamide-induced liver failure and encephalopathy. J Gastroenterol Hepatol. 2008;23:e236-42 pubmed
    Nitric oxide (NO) inhibition aggravates hepatic damage and encephalopathy and increases mortality in rats with thioacetamide (TAA)-induced acute liver failure...
  16. Aydin A, Küskü Kiraz Z, Dogru Abbasoglu S, Gulluoglu M, Uysal M, Kocak Toker N. Effect of carnosine against thioacetamide-induced liver cirrhosis in rat. Peptides. 2010;31:67-71 pubmed publisher
    ..Oxidative stress has been proposed to be involved in thioacetamide (TAA)-induced liver cirrhosis in rats, that is similar to human disease...
  17. Chan E, Montesinos M, Fernandez P, Desai A, Delano D, Yee H, et al. Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis. Br J Pharmacol. 2006;148:1144-55 pubmed
    ..05 ml in oil, 50 : 50 v : v, subcutaneously) and thioacetamide (100 mg kg(-1) in PBS, intraperitoneally) released more adenosine than those from untreated mice when cultured ..
  18. Roomi M, Gaal K, Yuan Q, French B, Fu P, Bardag Gorce F, et al. Preneoplastic liver cell foci expansion induced by thioacetamide toxicity in drug-primed mice. Exp Mol Pathol. 2006;81:8-14 pubmed
    ..3,5-pyridine decarboxylate for 5 months followed by drug withdrawal for 1 month (drug-primed mice) were given thioacetamide intraperitoneally, and the livers were subsequently studied at intervals up to 7 days...
  19. Ming Z, Fan Y, Yang X, Lautt W. Blockade of intrahepatic adenosine receptors improves urine excretion in cirrhotic rats induced by thioacetamide. J Hepatol. 2005;42:680-6 pubmed
    ..We hypothesize that the impaired urine excretion in liver cirrhosis is related to an increase in intrahepatic adenosine...
  20. Wang C, Jawan B, Lee T, Hung K, Chou W, Lu C, et al. Single injection of naked plasmid encoding alpha-melanocyte-stimulating hormone protects against thioacetamide-induced acute liver failure in mice. Biochem Biophys Res Commun. 2004;322:153-61 pubmed
    ..Acute liver damage was induced by intraperitoneal administration of thioacetamide. Hydrodynamics-based gene transfection with alpha-MSH expression plasmid via rapid tail vein injection was ..
  21. Park S, Shin H, Lee K, Lee M, Jang J. Differential expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in thioacetamide-induced chronic liver injury. J Korean Med Sci. 2010;25:570-6 pubmed publisher
    ..The aim of this study was to evaluate the expression patterns of MMPs and TIMPs during thioacetamide (TAA)-induced liver fibrogenesis. Chronic liver injury was induced with TAA (200 mg/kg i.p...
  22. Yogalakshmi B, Viswanathan P, Anuradha C. Investigation of antioxidant, anti-inflammatory and DNA-protective properties of eugenol in thioacetamide-induced liver injury in rats. Toxicology. 2010;268:204-12 pubmed publisher
    The present study investigated the preventive effect of eugenol, a naturally occurring food flavouring agent on thioacetamide (TA)-induced hepatic injury in rats. Adult male Wistar rats of body weight 150-180 g were used for the study...
  23. Wu Y, Fang H, Lin W. Post-treatment of Ganoderma lucidum reduced liver fibrosis induced by thioacetamide in mice. Phytother Res. 2010;24:494-9 pubmed publisher
    ..Repeated administration of thioacetamide (TAA) for 12 weeks to mice induced liver fibrosis...
  24. Mori Y, Izawa T, Takenaka S, Kuwamura M, Yamate J. Participation of functionally different macrophage populations and monocyte chemoattractant protein-1 in early stages of thioacetamide-induced rat hepatic injury. Toxicol Pathol. 2009;37:463-73 pubmed publisher
    ..In acute hepatic necrosis induced in rats by a single injection of 300 mg/kg body weight (BW) of thioacetamide (TAA), macrophage properties were investigated using single or double immunohistochemistry...
  25. Wang M, Chen Y, Chen I, Hsieh S, Chen S, Chiu C. Curcumin protects against thioacetamide-induced hepatic fibrosis by attenuating the inflammatory response and inducing apoptosis of damaged hepatocytes. J Nutr Biochem. 2012;23:1352-66 pubmed publisher
    ..Using the thioacetamide (TAA)-induced hepatic fibrosis animal model, we found that curcumin treatment up-regulated P53 protein ..
  26. Imanishi Y, Maeda N, Otogawa K, Seki S, Matsui H, Kawada N, et al. Herb medicine Inchin-ko-to (TJ-135) regulates PDGF-BB-dependent signaling pathways of hepatic stellate cells in primary culture and attenuates development of liver fibrosis induced by thioacetamide administration in rats. J Hepatol. 2004;41:242-50 pubmed
    ..We studied the effect of Inchin-ko-to (TJ-135), a herb medicine that has been clinically used for liver cirrhosis in Japan, on liver fibrosis in a rat model and on the function of stellate cells...
  27. Miranda A, Rodrigues D, Vieira L, Lima C, Rachid M, Vidigal P, et al. A thioacetamide-induced hepatic encephalopathy model in C57BL/6 mice: a behavioral and neurochemical study. Arq Neuropsiquiatr. 2010;68:597-602 pubmed
    ..In the present study, we aimed to standardize an animal model of HE induced by thioacetamide (TAA) in C57BL/6 mice evaluating behavioral symptoms in association with liver damage and alterations in ..
  28. Gupta N, Dixit V. Hepatoprotective activity of Cleome viscosa Linn. extract against thioacetamide-induced hepatotoxicity in rats. Nat Prod Res. 2009;23:1289-97 pubmed publisher
    ..The hepatoprotective activity of the ethanolic extract of leaves was investigated against thioacetamide-induced hepatotoxicity in rats...
  29. Avraham Y, Israeli E, Gabbay E, Okun A, Zolotarev O, Silberman I, et al. Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice. Neurobiol Dis. 2006;21:237-45 pubmed
    ..We used a mouse model of a thioacetamide induced fulminant hepatic failure...
  30. Galisteo M, Suarez A, Montilla M, Torres M, Fernandez M, Gil A, et al. Protective effects of Rosmarinus tomentosus ethanol extract on thioacetamide-induced liver cirrhosis in rats. Phytomedicine. 2006;13:101-8 pubmed
    ..ethanol extract of Rosmarinus tomentosus to protect rat liver in an experimental model of cirrhosis induced by thioacetamide (TAA) has been evaluated...
  31. Gribilas G, Zarros A, Zira A, Giaginis C, Tsourouflis G, Liapi C, et al. Involvement of hepatic stimulator substance in experimentally induced fibrosis and cirrhosis in the rat. Dig Dis Sci. 2009;54:2367-76 pubmed publisher
    ..Liver fibrosis and cirrhosis were induced in rats by thioacetamide (TAA) administration (300 mg/l) in the drinking water for 3 months, and animals were killed at 0, 1, 2, and 3 ..
  32. Lotkova H, Cervinkova Z, Kucera O, Rousar T, Krivakova P. S-adenosylmethionine exerts a protective effect against thioacetamide-induced injury in primary cultures of rat hepatocytes. Altern Lab Anim. 2007;35:363-71 pubmed
    ..b>Thioacetamide is frequently used as a model hepatotoxin, which causes in vivo centrilobular necrosis...
  33. Bruck R, Ashkenazi M, Weiss S, Goldiner I, Shapiro H, Aeed H, et al. Prevention of liver cirrhosis in rats by curcumin. Liver Int. 2007;27:373-83 pubmed
    ..The aim of the present study was to examine the efficacy of curcumin in preventing thioacetamide-induced cirrhosis and to unravel the mechanism of curcumin's effect on hepatic fibrosis in rats.
  34. Sanz N, Díez Fernández C, Andres D, Cascales M. Hepatotoxicity and aging: endogenous antioxidant systems in hepatocytes from 2-, 6-, 12-, 18- and 30-month-old rats following a necrogenic dose of thioacetamide. Biochim Biophys Acta. 2002;1587:12-20 pubmed
    ..studied in a model of hepatotoxicity induced in 2-, 6-, 12-, 18- and 30-month-old rats by a sublethal dose of thioacetamide (500 mg/kg body weight), a soft nucleophilic and hepatotoxic compound metabolized by the hepatic microsomal ..
  35. Honda H, Ikejima K, Hirose M, Yoshikawa M, Lang T, Enomoto N, et al. Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver. Hepatology. 2002;36:12-21 pubmed
    In this study, we investigated hepatic fibrogenesis caused by long-term thioacetamide (TAA) administration in ob/ob mice, a naturally occurring leptin deficient animal...
  36. Tunez I, Muñoz M, Villavicencio M, Medina F, de Prado E, Espejo I, et al. Hepato- and neurotoxicity induced by thioacetamide: protective effects of melatonin and dimethylsulfoxide. Pharmacol Res. 2005;52:223-8 pubmed
    ..oxidative stress, hepatic failure and blood urea nitrogen (BUN) level changes produced by a single dose of thioacetamide (TAA) in Wistar rats were studies...
  37. Schnur J, Oláh J, Szepesi A, Nagy P, Thorgeirsson S. Thioacetamide-induced hepatic fibrosis in transforming growth factor beta-1 transgenic mice. Eur J Gastroenterol Hepatol. 2004;16:127-33 pubmed
    ..Transforming growth factor beta-1 (TGF-beta 1) is thought to be one of the most important factors affecting the development of fibrotic processes in the liver...
  38. Devi S, Mehendale H. Microarray analysis of thioacetamide-treated type 1 diabetic rats. Toxicol Appl Pharmacol. 2006;212:69-78 pubmed
    ..Previously, we have shown that a normally non-lethal dose of thioacetamide (TA, 300 mg/kg) causes 90% mortality in type 1 diabetic (DB) rats due to inhibited tissue repair allowing ..
  39. Kim N, Hyun S, Jin C, Lee S, Lee D, Jeon T, et al. Pretreatment with 1,8-cineole potentiates thioacetamide-induced hepatotoxicity and immunosuppression. Arch Pharm Res. 2004;27:781-9 pubmed
    ..Subsequently, 1,8-cineole was applied to study the role of metabolic activation in thioacetamide-induced hepatotoxicity and/or immunotoxicity in animal models...
  40. Perez M, Suarez A, Gómez Capilla J, Sánchez Medina F, Gil A. Dietary nucleotide supplementation reduces thioacetamide-induced liver fibrosis in rats. J Nutr. 2002;132:652-7 pubmed
    ..The aim of this work was to evaluate the influence of dietary nucleotides on liver fibrosis induced by thioacetamide and to elucidate the mechanism by which nucleotides exert their protective effects...
  41. Sehrawat A, Khan T, Prasad L, Sultana S. Butea monosperma and chemomodulation: protective role against thioacetamide-mediated hepatic alterations in Wistar rats. Phytomedicine. 2006;13:157-63 pubmed
    ..b>Thioacetamide (TAA) was used to induce tumor promotion response and oxidative stress and caused significant depletion in the ..
  42. Chen T, Subeq Y, Lee R, Chiou T, Hsu B. Single dose intravenous thioacetamide administration as a model of acute liver damage in rats. Int J Exp Pathol. 2008;89:223-31 pubmed publisher
    b>Thioacetamide (TAA) has been used extensively in the development of animal models of acute liver injury. Frequently, TAA is administered intraperitoneally to induce liver damage under anaesthesia...
  43. Pooranaperundevi M, Sumiyabanu M, Viswanathan P, Sundarapandiyan R, Anuradha C. Insulin resistance induced by a high-fructose diet potentiates thioacetamide hepatotoxicity. Singapore Med J. 2010;51:389-98 pubmed
    ..This study investigated the susceptibility of the liver to the toxic actions of thioacetamide (TA) in a rat model of IR, induced by feeding the rats a high-fructose diet (60 g/100 g) for 30 days.
  44. Shaker M, Salem H, Shiha G, Ibrahim T. Nilotinib counteracts thioacetamide-induced hepatic oxidative stress and attenuates liver fibrosis progression. Fundam Clin Pharmacol. 2011;25:248-57 pubmed publisher
    ..effects of imatinib and nilotinib to that of silymarin on established liver fibrosis and oxidative stress in a thioacetamide (TAA) rat model. Male Wistar rats received intraperitoneal (i.p...
  45. Hung K, Lee T, Chou W, Wu C, Cho C, Lu C, et al. Interleukin-10 gene therapy reverses thioacetamide-induced liver fibrosis in mice. Biochem Biophys Res Commun. 2005;336:324-31 pubmed
    ..Liver fibrosis was induced by long-term thioacetamide administration in mice...
  46. Swapna I, Sathyasaikumar K, Murthy C, Gupta A, Senthilkumaran B. Alterations in kinetic and thermotropic properties of cerebral membrane-bound acetylcholineesterase during thioacetamide-induced hepatic encephalopathy: correlation with membrane lipid changes. Brain Res. 2007;1153:188-95 pubmed
    ..HE) associated with acute liver failure induced experimentally by the administration of the hepatotoxin thioacetamide (TAA). Activity of AchE decreased significantly following TAA administration...
  47. Bautista M, Andres D, Cascales M, Morales González J, Sánchez Reus M. Effect of gadolinium chloride on liver regeneration following thioacetamide-induced necrosis in rats. Int J Mol Sci. 2010;11:4426-40 pubmed publisher
    ..The effect of GD was studied in reference to postnecrotic liver regeneration induced in rats by thioacetamide (TA). Rats, intravenously pretreated with a single dose of GD (0...
  48. Natarajan S, Thomas S, Ramamoorthy P, Basivireddy J, Pulimood A, Ramachandran A, et al. Oxidative stress in the development of liver cirrhosis: a comparison of two different experimental models. J Gastroenterol Hepatol. 2006;21:947-57 pubmed
    Oxidative stress has been implicated in liver cirrhosis. Carbon tetrachloride and thioacetamide are the most widely used models to develop cirrhosis in rats and the present study compares oxidative stress in the liver induced by these ..
  49. Li J, Li J, Li S, He B, Mi Y, Cao H, et al. Ameliorative effect of grape seed proanthocyanidin extract on thioacetamide-induced mouse hepatic fibrosis. Toxicol Lett. 2012;213:353-60 pubmed publisher
    ..effect of the grape seed proanthocyanidin extract (GSPE) on developing hepatic fibrosis that was induced by thioacetamide (TAA) in mice...
  50. Hasegawa M, Ide M, Takenaka S, Yamate J, Tsuyama S. Urinary metabolic fingerprinting for thioacetamide-induced rat acute hepatic injury using fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS), with reference to detection of potential biomarkers for hepatotoxicity. Toxicol Pathol. 2007;35:570-5 pubmed
    ..metabolic fingerprinting using Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS) in the thioacetamide (TAA)-induced rat model of acute hepatic injury to search for useful biomarkers involved in the acute hepatic ..
  51. Ahmad A, Pillai K, Najmi A, Ahmad S, Pal S, Balani D. Evaluation of hepatoprotective potential of jigrine post-treatment against thioacetamide induced hepatic damage. J Ethnopharmacol. 2002;79:35-41 pubmed
    ..Data on the biochemical parameters revealed hepatoprotective potential of jigrine post-treatment against thioacetamide induced hepatotoxicity in rats...
  52. Saran T, Hilgier W, Urbanska E, Turski W, Albrecht J. Kynurenic acid synthesis in cerebral cortical slices of rats with progressing symptoms of thioacetamide-induced hepatic encephalopathy. J Neurosci Res. 2004;75:436-40 pubmed
    ..HE symptoms accompanying acute liver failure induced by one, two, or three intraperitoneal administrations of thioacetamide (TAA) at 24-hr intervals...
  53. Chilakapati J, Shankar K, Korrapati M, Hill R, Mehendale H. Saturation toxicokinetics of thioacetamide: role in initiation of liver injury. Drug Metab Dispos. 2005;33:1877-85 pubmed
    b>Thioacetamide (TA), a potent centrilobular hepatotoxicant, undergoes a two-step bioactivation mediated by microsomal CYP2E1 to TA sulfoxide (TASO), and further to TA-S,S-dioxide (TASO2), a reactive metabolite that initiates cellular ..