pentanols

Summary

Summary: Isomeric forms and derivatives of pentanol (C5H11OH).

Top Publications

  1. Shafiee A, Bucolo C, Budzynski E, Ward K, Lopez F. In vivo ocular efficacy profile of mapracorat, a novel selective glucocorticoid receptor agonist, in rabbit models of ocular disease. Invest Ophthalmol Vis Sci. 2011;52:1422-30 pubmed publisher
    ..The effects of topical BOL-303242-X and DEX on intraocular pressure (IOP) and body weight changes were also evaluated...
  2. Li S, Wen J, Jia X. Engineering Bacillus subtilis for isobutanol production by heterologous Ehrlich pathway construction and the biosynthetic 2-ketoisovalerate precursor pathway overexpression. Appl Microbiol Biotechnol. 2011;91:577-89 pubmed publisher
    ..Under microaerobic condition, the engineered B. subtilis produced up to 2.62 g/L isobutanol in shake-flask fed-batch fermentation, which was 21.3% higher than that in batch fermentation...
  3. Liu Z, Ge M, Wang W, Yin S, Tong S. The uptake of 2-methyl-3-buten-2-ol into aqueous mixed solutions of sulfuric acid and hydrogen peroxide. Phys Chem Chem Phys. 2011;13:2069-75 pubmed publisher
    ..Thus, the multiphase acid-catalyzed oxidation of MBO with H(2)O(2) might be a potential contributor to SOA loading...
  4. Ashe M, Slaven J, De Long S, Ibrahimo S, Sachs A. A novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcohols. EMBO J. 2001;20:6464-74 pubmed
    ..This represents one of the key limiting steps of translation initiation and we provide evidence that fusel alcohols target eIF2B in order to bring about translational regulation...
  5. Schoondermark Stolk S, Tabernero M, Chapman J, ter Schure E, Verrips C, Verkleij A, et al. Bat2p is essential in Saccharomyces cerevisiae for fusel alcohol production on the non-fermentable carbon source ethanol. FEMS Yeast Res. 2005;5:757-66 pubmed
    ..Therefore we conclude that the expression of BAT2 is essential for 3-methyl-1-butanol formation on the non-fermentable carbon source, ethanol...
  6. Kern K, Nunn C, Pichova A, Dickinson J. Isoamyl alcohol-induced morphological change in Saccharomyces cerevisiae involves increases in mitochondria and cell wall chitin content. FEMS Yeast Res. 2004;5:43-9 pubmed
    ..Filaments have an increased chitin content which is distributed over the majority of their surface, and is not confined to bud scars and the chitin ring between mother and daughter cells as in yeast-form cells...
  7. Connor M, Cann A, Liao J. 3-Methyl-1-butanol production in Escherichia coli: random mutagenesis and two-phase fermentation. Appl Microbiol Biotechnol. 2010;86:1155-64 pubmed publisher
    ..Investigation of the host's sensitivity to 3-methyl-1-butanol directed development of a two-phase fermentation process in which titers reached 9.5 g/L of 3-methyl-1-butanol with a yield of 0.11 g/g glucose after 60 h...
  8. Zhang J, Cavet M, VanDerMeid K, Salvador Silva M, Lopez F, Ward K. BOL-303242-X, a novel selective glucocorticoid receptor agonist, with full anti-inflammatory properties in human ocular cells. Mol Vis. 2009;15:2606-16 pubmed
    ..Data from in vitro and in vivo studies suggest an improved side-effect profile of this compound compared to classical glucocorticoids. The aim of this study was to determine the anti-inflammatory effect of BOL-303242-X in ocular cells...
  9. Ozaki K, Ohta A, Iwata C, Horikawa A, Tsuji K, Ito E, et al. Lysis of cyanobacteria with volatile organic compounds. Chemosphere. 2008;71:1531-8 pubmed publisher
    ..This color change is similar to the phenomenon observed when a sudden decline in growth of cyanobacteria begins in a natural environment...

More Information

Publications62

  1. Withers S, Gottlieb S, Lieu B, Newman J, Keasling J. Identification of isopentenol biosynthetic genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity. Appl Environ Microbiol. 2007;73:6277-83 pubmed
    ..Expression of nudF in E. coli engineered with the mevalonate-based isopentenyl pyrophosphate biosynthetic pathway resulted in the production of isopentenol...
  2. Song Y, Cygnar K, Sagdullaev B, Valley M, Hirsh S, Stephan A, et al. Olfactory CNG channel desensitization by Ca2+/CaM via the B1b subunit affects response termination but not sensitivity to recurring stimulation. Neuron. 2008;58:374-86 pubmed publisher
  3. Connor M, Liao J. Engineering of an Escherichia coli strain for the production of 3-methyl-1-butanol. Appl Environ Microbiol. 2008;74:5769-75 pubmed publisher
    ..This work demonstrates the feasibility of production of 3-methyl-1-butanol as a biofuel and shows promise in using E. coli as a host for production...
  4. Yang L, Wang C, Ye J, Li H. Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves on CCl4-induced hepatotoxicity in rats. Fitoterapia. 2011;82:834-40 pubmed publisher
    ..In general, the effects of GBP were not significantly different from those of the standard drug Essentiale...
  5. Baiula M, Sparta A, Bedini A, Carbonari G, Bucolo C, Ward K, et al. Eosinophil as a cellular target of the ocular anti-allergic action of mapracorat, a novel selective glucocorticoid receptor agonist. Mol Vis. 2011;17:3208-23 pubmed
    ..This study assessed the anti-allergic activity of mapracorat at the ocular level and whether eosinophils and mast cells are targets of its action...
  6. Cavet M, Harrington K, Ward K, Zhang J. Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cells. Mol Vis. 2010;16:1791-800 pubmed
    ..This study assessed the anti-inflammatory effects of mapracorat in an in vitro osmotic stress model which mimics some of the pathophysiological changes seen in dry eye...
  7. Vadali R, Bennett G, San K. Applicability of CoA/acetyl-CoA manipulation system to enhance isoamyl acetate production in Escherichia coli. Metab Eng. 2004;6:294-9 pubmed
    ..The acetate production pathway was inactivated under elevated CoA/acetyl-CoA conditions, which lead to a further increase in isoamyl acetate production...
  8. Atsumi S, Wu T, Machado I, Huang W, Chen P, Pellegrini M, et al. Evolution, genomic analysis, and reconstruction of isobutanol tolerance in Escherichia coli. Mol Syst Biol. 2010;6:449 pubmed publisher
    ..Interestingly, improved isobutanol tolerance did not increase the final titer of isobutanol production...
  9. Pfeffer B, DeWitt C, Salvador Silva M, Cavet M, Lopez F, Ward K. Reduced myocilin expression in cultured monkey trabecular meshwork cells induced by a selective glucocorticoid receptor agonist: comparison with steroids. Invest Ophthalmol Vis Sci. 2010;51:437-46 pubmed publisher
    ..To assess in vitro myocilin (MYOC) expression in trabecular meshwork (TM) cells exposed to BOL-303242-X, a selective glucocorticoid receptor (GR) agonist (SEGRA), in comparison with dexamethasone (DEX), and prednisolone acetate (PA)...
  10. Chan A, Galloway M, Kwan A, Chhabra P, Keutsch F, Wennberg P, et al. Photooxidation of 2-methyl-3-Buten-2-ol (MBO) as a potential source of secondary organic aerosol. Environ Sci Technol. 2009;43:4647-52 pubmed
    ..Despite its structural similarity to isoprene, photooxidation of MBO is not expected to make a significant contribution to SOA formation...
  11. Proksch J, Lowe E, Ward K. Ocular pharmacokinetics of mapracorat, a novel, selective glucocorticoid receptor agonist, in rabbits and monkeys. Drug Metab Dispos. 2011;39:1181-7 pubmed publisher
    ..The favorable pharmacokinetic profile of mapracorat supports further clinical investigation and suggests that a convenient daily dosing regimen may be efficacious for this novel ophthalmic anti-inflammatory therapy...
  12. Hauser M, Horn P, Tournu H, Hauser N, Hoheisel J, Brown A, et al. A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase. FEMS Yeast Res. 2007;7:84-92 pubmed
    ..These results indicate a previously unsuspected and novel role for the GRE2 gene product as a suppressor of filamentation by virtue of encoding isovaleraldehyde reductase activity...
  13. Tao R, Wang C, Kong Z. Antibacterial/antifungal activity and synergistic interactions between polyprenols and other lipids isolated from Ginkgo biloba L. leaves. Molecules. 2013;18:2166-82 pubmed publisher
    ..A proportion of isophytol and GBP of 38.19%:61.81% (wt/wt) was determined by mixture design as the optimal proportion for the synergistic effect of GBP with isophytol against Salmonella enterica...
  14. Schoondermark Stolk S, Jansen M, Veurink J, Verkleij A, Verrips C, Euverink G, et al. Rapid identification of target genes for 3-methyl-1-butanol production in Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 2006;70:237-46 pubmed
    ..The results indicate that this is a rapid and valuable approach for identification of interesting target genes for improvement of yeast strains used in industrial processes...
  15. Schäcke H, Zollner T, Docke W, Rehwinkel H, Jaroch S, Skuballa W, et al. Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases. Br J Pharmacol. 2009;158:1088-103 pubmed publisher
    ..Here we report on ZK 245186, a novel, non-steroidal, low-molecular-weight, glucocorticoid receptor-selective agonist for the topical treatment of inflammatory dermatoses...
  16. Zhang K, Sawaya M, Eisenberg D, Liao J. Expanding metabolism for biosynthesis of nonnatural alcohols. Proc Natl Acad Sci U S A. 2008;105:20653-8 pubmed publisher
    ..This work demonstrates an approach to build artificial metabolism beyond the natural metabolic network. Nonnatural metabolites such as long chain alcohols are now included in the metabolite family of living systems...
  17. Dickinson J, Lanterman M, Danner D, Pearson B, Sanz P, Harrison S, et al. A 13C nuclear magnetic resonance investigation of the metabolism of leucine to isoamyl alcohol in Saccharomyces cerevisiae. J Biol Chem. 1997;272:26871-8 pubmed
  18. L Etoile N, Bargmann C. Olfaction and odor discrimination are mediated by the C. elegans guanylyl cyclase ODR-1. Neuron. 2000;25:575-86 pubmed
    ..Olfactory discrimination is also disrupted by ODR-1 overexpression, probably by overproduction of the shared second messenger cGMP. We propose that AWC odorant signaling pathways are insulated to permit odor discrimination...
  19. Yamada H, Nakatani K. Odorant-induced hyperpolarization and suppression of cAMP-activated current in newt olfactory receptor neurons. Chem Senses. 2001;26:25-34 pubmed
    ..Given that this inhibitory effect of odorants can affect excitation caused by other odorants, we suggest that it might play a role in coding odorants in olfactory receptor neurons...
  20. Kawai F, Kurahashi T, Kaneko A. Nonselective suppression of voltage-gated currents by odorants in the newt olfactory receptor cells. J Gen Physiol. 1997;109:265-72 pubmed
    ..The nonselective blockage of ionic channels observed here is consistent with the previous notion that the suppression of the transduction current by odorants is due to the direst blockage of transduction channels...
  21. Dickinson J, Harrison S, Dickinson J, Hewlins M. An investigation of the metabolism of isoleucine to active Amyl alcohol in Saccharomyces cerevisiae. J Biol Chem. 2000;275:10937-42 pubmed
  22. Scognamiglio J, Jones L, Letizia C, Api A. Fragrance material review on 2-methyl-4-phenylpentanol. Food Chem Toxicol. 2012;50 Suppl 2:S209-14 pubmed publisher
    ..2012) for an overall assessment of the safe use of this material and all Aryl Alkyl Alcohols in fragrances...
  23. Zaki M, Knözinger H, Tesche B. Structural and morphological consequences of high-temperature treatments of hydroxyapatite in the absence or presence of HCl vapor. Langmuir. 2006;22:749-55 pubmed
    ..In the atmosphere of wet HCl, HAP was shown to suffer loss of chemical integrity, facilitated by its carbonated domains, as well as disintegration (or erosion) of particle aggregates and creation of what appeared to be deep groves...
  24. Wang T, Liu Z, Ge M, Wang W. [Uptake of 3-methyl-3-buten-1-ol into aqueous mixed solution of sulfuric acid and hydrogen peroxide]. Huan Jing Ke Xue. 2011;32:3599-605 pubmed
    ..Thus, the heterogeneous acid-catalyzed oxidation of MBO331 with H2O2 might be a significant contributor to SOA loading...
  25. Tsakiris A, Kandylis P, Bekatorou A, Kourkoutas Y, Koutinas A. Dry red wine making using yeast immobilized on cork pieces. Appl Biochem Biotechnol. 2010;162:1316-26 pubmed publisher
    ..Differences in the headspace aroma profile in wines produced by immobilized and free cells were found by GC-MS analysis, but no cork taint compounds were detected...
  26. Liu W, Guo R. The photostabilization of hemoglobin in Triton X-100 aqueous solution and Triton X-100/n-C5H11OH/H2O microemulsion. Photochem Photobiol. 2010;86:835-43 pubmed publisher
  27. McGinty D, Jones L, Letizia C, Api A. Fragrance material review on 3-methyl-2-buten-1-ol. Food Chem Toxicol. 2010;48 Suppl 3:S64-9 pubmed publisher
    ..A toxicologic and dermatologic review of 3-methyl-2-buten-1-ol when used as a fragrance ingredient is presented...
  28. Kamath V, Moberg P, Kohler C, Gur R, Turetsky B. Odor hedonic capacity and anhedonia in schizophrenia and unaffected first-degree relatives of schizophrenia patients. Schizophr Bull. 2013;39:59-67 pubmed publisher
    ..We also examine odor valence processing unirhinally, rather than birhinally, to probe possible lateralized differences in patients' hedonic processing deficits...
  29. Tzhayik O, Cavaco Paulo A, Gedanken A. Fragrance release profile from sonochemically prepared protein microsphere containers. Ultrason Sonochem. 2012;19:858-63 pubmed publisher
    ..This event coincides with the full evaporation of water. For morphological characterization we dyed the AA with Nile red, and used SEM, ESEM, Cryo-SEM, light microscopy, and confocal laser scanning microscopy measurements...
  30. Wang L, Chen L, Jacob T. Evidence for peripheral plasticity in human odour response. J Physiol. 2004;554:236-44 pubmed
    ..These observations support the existence of odourant-specific plasticity in the peripheral olfactory system...
  31. Hesek D, Lee M, Zajicek J, Fisher J, Mobashery S. Synthesis and NMR characterization of (Z,Z,Z,Z,E,E,?)-heptaprenol. J Am Chem Soc. 2012;134:13881-8 pubmed publisher
    ..The availability by this synthesis of (Z(4),E(2),?)-heptaprenol 4 in gram quantities will enable preparative access to key reagents for the study of the biosynthesis of the bacterial cell envelope...
  32. Pierce J, Cohen A, Ulrich P. Responsivity to two odorants, androstenone and amyl acetate, and the affective impact of odors on interpersonal relationships. J Comp Psychol. 2004;118:14-9 pubmed
    ..Responsivity to certain odorants may be an important factor affecting human social interactions...
  33. Jiang X, Kakuda K, Matsukawa S, Yamamichi H, Kojima S, Yamamoto Y. Synthesis and application of a bidentate ligand based on decafluoro-3-phenyl-3-pentanol: steric effect of pentafluoroethyl groups on the stereomutation of O-equatorial C-apical spirophosphoranes. Chem Asian J. 2007;2:314-23 pubmed
    ..The activation enthalpy for the stereomutation of the former to the latter was higher than that of the phosphorane with Martin ligands by 5.1 kcal mol(-1)...
  34. Müller R, Rohwerder T, Harms H. Degradation of fuel oxygenates and their main intermediates by Aquincola tertiaricarbonis L108. Microbiology. 2008;154:1414-21 pubmed publisher
    ..The possible origin of its exceptional metabolic capability is discussed in terms of the evolution of enzymic activities involved in the conversion of compounds carrying tertiary butyl groups...
  35. Toth M, Szarukán I, Dorogi B, Gulyás A, Nagy P, Rozgonyi Z. Male and female noctuid moths attracted to synthetic lures in Europe. J Chem Ecol. 2010;36:592-8 pubmed publisher
    ..while isoamyl alcohol-based lures attracted species mostly from the Noctuinae or Hadeninae subfamilies...
  36. Bustamante V, Martinez Flores I, Vlamakis H, Zusman D. Analysis of the Frz signal transduction system of Myxococcus xanthus shows the importance of the conserved C-terminal region of the cytoplasmic chemoreceptor FrzCD in sensing signals. Mol Microbiol. 2004;53:1501-13 pubmed
    ..Thus, signal input to the Frz system must be sensed by the conserved C-terminal module of FrzCD and not the usual N-terminal region. These results indicate an alternative mechanism for signal sensing with this cytoplasmic MCP...
  37. Hirooka K, Yamamoto Y, Tsutsui N, Tanaka T. Improved production of isoamyl acetate by a sake yeast mutant resistant to an isoprenoid analog and its dependence on alcohol acetyltransferase activity, but not on isoamyl alcohol production. J Biosci Bioeng. 2005;99:125-9 pubmed
    ..Flavor compound production in sake brewing could be improved using strain A1, resulting in a 1.4-fold increase in isoamyl acetate production in spite of a limited production of isoamyl alcohol...
  38. Watson S, Risling T, Hermann P, Wildering W. Failure of delayed nonsynaptic neuronal plasticity underlies age-associated long-term associative memory impairment. BMC Neurosci. 2012;13:103 pubmed publisher
  39. Takano D, Nagamitsu T, Ui H, Shiomi K, Yamaguchi Y, Masuma R, et al. Total synthesis of nafuredin, a selective NADH-fumarate reductase inhibitor. Org Lett. 2001;3:2289-91 pubmed
    ..The C1-C8 and C9-C18 segments were derived efficiently from D-glucose and (S)-(-)-2-methyl-1-butanol, respectively, coupled by stereoselective Julia olefination, and converted to nafuredin...
  40. Romero M, Calvo L, Alba C, Daneshfar A. A kinetic study of isoamyl acetate synthesis by immobilized lipase-catalyzed acetylation in n-hexane. J Biotechnol. 2007;127:269-77 pubmed
    ..Equation predictions and experimental reaction rate values matched very well at conditions where acetic acid concentration in the medium was low...
  41. Xu T, Jin M, Xie Z, Jiang Z, Kuang Q, Wu H, et al. Tensions at liquid interfaces: a general filter for the separation of micro-/nanoparticles. Langmuir. 2008;24:2281-3 pubmed publisher
    ..Furthermore, we applied our strategy to the separation of two size-distributed Cu2O particles by using the water and n-pentanol interface, which demonstrates the feasibility of the proposed separation method...
  42. Erez Y, Amdursky N, Gepshtein R, Huppert D. Temperature and viscosity dependence of the nonradiative decay rates of auramine-O and thioflavin-T in glass-forming solvents. J Phys Chem A. 2012;116:12056-64 pubmed publisher
    ..The k(nr) values of AuO are twice those of ThT along the whole temperature range. The temperature dependence of k(nr) is consistent with the nonradiative model suggested by Glasbeek and co-workers...
  43. Arguello J, Sellanes C, Lou Y, Raguso R. Can yeast (S. cerevisiae) metabolic volatiles provide polymorphic signaling?. PLoS ONE. 2013;8:e70219 pubmed publisher
    ..Though unable to correlate the genetic and volatile measurements, our data point clear ways forward for behavioral assays aimed at understanding the implications of this variation...
  44. Bamba T, Fukasaki W, Kajiyama S, Ute K, Kitayama T, Kobayashi A. High-resolution analysis of polyprenols by supercritical fluid chromatography. J Chromatogr A. 2001;911:113-7 pubmed
    ..This method is very useful for the analysis of structurally close polyprenol analogues of rubber plant metabolites...
  45. You H, Wang J, Liu J, Feng F, Ni D, Jin Z. [Olfactory functional magnetic resonance imaging with modified OEP-98C olfactometer and event-related design]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2009;31:134-8 pubmed
    ..To explore the feasibility of functional magnetic resonance imaging (fMRI) in analysis of olfaction function with modified OEP-98C olfactometer and event-related design...
  46. Semple S, Zians J, Strathdee S, Patterson T. Sexual marathons and methamphetamine use among HIV-positive men who have sex with men. Arch Sex Behav. 2009;38:583-90 pubmed publisher
    ..In multivariate analyses, use of sildenafil in the past two months was significantly correlated with participation in sexual marathons. Findings are discussed in terms of their implications for HIV/STI prevention and intervention...
  47. Letisse F, Lamare S, Legoy M, Graber M. Solid/gas biocatalysis: an appropriate tool to study the influence of organic components on kinetics of lipase-catalyzed alcoholysis. Biochim Biophys Acta. 2003;1652:27-34 pubmed
  48. Ravyts F, Steen L, Goemaere O, Paelinck H, De Vuyst L, Leroy F. The application of staphylococci with flavour-generating potential is affected by acidification in fermented dry sausages. Food Microbiol. 2010;27:945-54 pubmed publisher
    ..Inoculation with S. sciuri alphaSg2, S. succinus 4PB1, or S. xylosus 3PA6 led to 3-methyl-1-butanol and acetoin production in Southern-European type of fermented dry sausages, which was not observed with S. carnosus 833...
  49. Lang K, Väli M, Szucs S, Adany R, McKee M. The composition of surrogate and illegal alcohol products in Estonia. Alcohol Alcohol. 2006;41:446-50 pubmed
    ..To identify the composition of illegal and surrogate alcohol products consumed in Estonia...
  50. Mikhail A, Sharifpoor S, Amsden B. Initiator structure influence on thermal and rheological properties of oligo(epsilon-caprolactone). J Biomater Sci Polym Ed. 2006;17:291-301 pubmed
    ..The order of melt viscosity increased with initiator conformer as follows: cis, trans, primary and secondary. The results were explained in terms of oligomer chain flexibility in the melt...
  51. Santos G, Coffin P, Das M, Matheson T, Demicco E, Raiford J, et al. Dose-response associations between number and frequency of substance use and high-risk sexual behaviors among HIV-negative substance-using men who have sex with men (SUMSM) in San Francisco. J Acquir Immune Defic Syndr. 2013;63:540-4 pubmed publisher
    ..81 (95% CI, 12.25 to 23.08), 27.31 (95% CI, 18.93 to 39.39), and 46.38 (95% CI, 30.65 to 70.19), respectively. High-risk sexual behaviors were strongly associated with frequency and number of substances used. ..
  52. Lam Y, Cohen L, Zochowski M. Odorant specificity of three oscillations and the DC signal in the turtle olfactory bulb. Eur J Neurosci. 2003;17:436-46 pubmed
    ..Qualitative differences between the oscillations in the turtle and those in two invertebrate phyla suggest that different odour processing strategies may be used...
  53. Kawano S, Hasegawa J, Yasohara Y. Efficient preparation of (R)-3-hydroxypentanenitrile with high enantiomeric excess by enzymatic reduction with subsequent enhancement of the optical purity by lipase-catalyzed ester hydrolysis. Biosci Biotechnol Biochem. 2012;76:1796-8 pubmed
    ..5% ee which was then converted to (R)-1-(cyanomethyl) propyl n-butyrate (3b). Subsequent lipase-catalyzed enantioselective hydrolysis of 3b gave (R)-1 in a high yield with over 99% ee...