fatty acids

Summary

Summary: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)

Top Publications

  1. Hodson L, Eyles H, McLachlan K, Bell M, Green T, Skeaff C. Plasma and erythrocyte fatty acids reflect intakes of saturated and n-6 PUFA within a similar time frame. J Nutr. 2014;144:33-41 pubmed publisher
    ..There were no differences in linoleic or pentadecanoic acid composition of adipose tissue TG. These results suggest plasma and erythrocyte FAs reflect intakes of SFA and n-6 PUFA over a similar period of time. ..
  2. Wendel A, Cooper D, Ilkayeva O, Muoio D, Coleman R. Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation. J Biol Chem. 2013;288:27299-306 pubmed publisher
    ..5-fold higher. Taken together, these data demonstrate that GPAT1, but not GPAT4, is required to incorporate de novo synthesized fatty acids into TAG and to divert them away from oxidation.
  3. Foolad N, Brezinski E, Chase E, Armstrong A. Effect of nutrient supplementation on atopic dermatitis in children: a systematic review of probiotics, prebiotics, formula, and fatty acids. JAMA Dermatol. 2013;149:350-5 pubmed
    To identify whether nutrient supplementation with probiotics, prebiotics, formula, or fatty acids prevents the development of atopic dermatitis (AD) or reduces the severity of AD in newborns to children younger than 3 years...
  4. Ramsden C, Faurot K, ZAMORA D, Suchindran C, Macintosh B, Gaylord S, et al. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain. 2013;154:2441-51 pubmed publisher
    Omega-3 and n-6 fatty acids are biosynthetic precursors to lipid mediators with antinociceptive and pronociceptive properties...
  5. Winichayakul S, Scott R, Roldan M, Hatier J, Livingston S, Cookson R, et al. In vivo packaging of triacylglycerols enhances Arabidopsis leaf biomass and energy density. Plant Physiol. 2013;162:626-39 pubmed publisher
    ..We also demonstrate that the combination of Cys-oleosin and DGAT1 resulted in the highest accumulation of fatty acids in the model single-cell eukaryote, Saccharomyces cerevisiae...
  6. Salman S, Heidelberg T, Bin Tajuddin H. N-linked glycolipids by Staudinger coupling of glycosylated alkyl diazides with fatty acids. Carbohydr Res. 2013;375:55-62 pubmed publisher
    ..The assembly behavior of both glycolipid types was investigated by optical polarizing microscopy, DSC and surface tension studies. ..
  7. Nobusawa T, Okushima Y, Nagata N, Kojima M, Sakakibara H, Umeda M. Synthesis of very-long-chain fatty acids in the epidermis controls plant organ growth by restricting cell proliferation. PLoS Biol. 2013;11:e1001531 pubmed publisher
    ..Very-long-chain fatty acids (VLCFAs) are synthesized in the epidermis and used in the formation of cuticular wax...
  8. Kumar M, Praveenkumar R, Ilavarasi A, Rajeshwari K, Thajuddin N. Biochemical changes of fresh water cyanobacteria Dolichospermum flos-aquae NTMS07 to chromium-induced stress with special reference to antioxidant enzymes and cellular fatty acids. Bull Environ Contam Toxicol. 2013;90:730-5 pubmed publisher
    ..the antioxidative enzymes superoxide dismutase (SOD) and catalase (CAT) were measured, and the composition of fatty acids was evaluated at a concentration of 5 mg Cr/L...
  9. Matsumoto C, Hanson N, Tsai M, Glynn R, Gaziano J, Djousse L. Plasma phospholipid saturated fatty acids and heart failure risk in the Physicians' Health Study. Clin Nutr. 2013;32:819-23 pubmed publisher
    Previous studies have suggested that some plasma phospholipid saturated fatty acids (SFA) are associated with an increased risk of coronary heart disease and hypertension, major risk factors for heart failure (HF)...

More Information

Publications62

  1. Price E, Armstrong C, Guglielmo C, Staples J. Selective mobilization of saturated fatty acids in isolated adipocytes of hibernating 13-lined ground squirrels Ictidomys tridecemlineatus. Physiol Biochem Zool. 2013;86:205-12 pubmed publisher
    b>Fatty acids are not mobilized from adipocyte triacylglycerols uniformly but rather some are preferentially mobilized while others are preferentially retained...
  2. Song M, Pei H, Hu W, Ma G. Evaluation of the potential of 10 microalgal strains for biodiesel production. Bioresour Technol. 2013;141:245-51 pubmed publisher
    ..50%), C14:0 (11.68%) and C16:1 (22.34%) as well as suitable biodiesel properties of higher cetane number (55.10), lower iodine number (99.2 gI?/100g) and relatively low cloud point (4.47 °C). ..
  3. Bates P, Johnson S, Cao X, Li J, Nam J, Jaworski J, et al. Fatty acid synthesis is inhibited by inefficient utilization of unusual fatty acids for glycerolipid assembly. Proc Natl Acad Sci U S A. 2014;111:1204-9 pubmed publisher
    Degradation of unusual fatty acids through ?-oxidation within transgenic plants has long been hypothesized as a major factor limiting the production of industrially useful unusual fatty acids in seed oils...
  4. Guest J, Garg M, Bilgin A, Grant R. Relationship between central and peripheral fatty acids in humans. Lipids Health Dis. 2013;12:79 pubmed publisher
    In recent years the physiological and pathological importance of fatty acids in both the periphery and central nervous system (CNS) has become increasingly apparent...
  5. Jiang H, Khan S, Wang Y, Charron G, He B, Sebastian C, et al. SIRT6 regulates TNF-? secretion through hydrolysis of long-chain fatty acyl lysine. Nature. 2013;496:110-3 pubmed publisher
    ..The discovery of SIRT6 as an enzyme that controls protein lysine fatty acylation provides new opportunities to investigate the physiological function of a protein post-translational modification that has been little studied until now. ..
  6. Mahendran Y, Agren J, Uusitupa M, Cederberg H, Vangipurapu J, Stancakova A, et al. Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes. Am J Clin Nutr. 2014;99:79-85 pubmed publisher
    The significance of erythrocyte membrane fatty acids (EMFAs) and their ratios to predict hyperglycemia and incident type 2 diabetes is unclear.
  7. Clark S, Thomas C, Hammond V, Aldrovandi M, Wilkinson G, Hart K, et al. Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation. Proc Natl Acad Sci U S A. 2013;110:5875-80 pubmed publisher
    ..APL with longer or shorter fatty acyl chains. This finding demonstrates fatty acids as molecular determinants of APL that regulate hemostasis...
  8. Costa A, Silva M, Alfaia C, Pires V, Fontes C, Bessa R, et al. Genetic background and diet impact beef fatty acid composition and stearoyl-CoA desaturase mRNA expression. Lipids. 2013;48:369-81 pubmed publisher
    ..Meat from Barrosã bulls fed the low silage diet was richer in monounsaturated fatty acids, CLA and trans fatty acids, when compared to that from Alentejana bulls...
  9. Montgomery M, Osborne B, Brown S, Small L, Mitchell T, Cooney G, et al. Contrasting metabolic effects of medium- versus long-chain fatty acids in skeletal muscle. J Lipid Res. 2013;54:3322-33 pubmed publisher
    Dietary intake of long-chain fatty acids (LCFAs) plays a causative role in insulin resistance and risk of diabetes...
  10. Parsons J, Kukula M, Jackson P, Pulse M, Simecka J, Valtierra D, et al. Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252. Antimicrob Agents Chemother. 2013;57:2182-90 pubmed publisher
    ..These data indicate that the effects of AFN-1252 on virulence factor gene expression depend on the physiological state of the bacteria. ..
  11. Snodgrass R, Huang S, Choi I, Rutledge J, Hwang D. Inflammasome-mediated secretion of IL-1? in human monocytes through TLR2 activation; modulation by dietary fatty acids. J Immunol. 2013;191:4337-47 pubmed publisher
    ..mice are protected from high-fat diet-induced inflammation and insulin resistance, suggesting that saturated fatty acids derived from the high-fat diet activate TLR-mediated proinflammatory signaling pathways and induce insulin ..
  12. Laurent G, German N, Saha A, de Boer V, Davies M, Koves T, et al. SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol Cell. 2013;50:686-98 pubmed publisher
    ..In sum, this work elucidates SIRT4 as an important regulator of lipid homeostasis, identifies MCD as a SIRT4 target, and deepens our understanding of the malonyl CoA regulatory axis. ..
  13. Walley J, Kliebenstein D, Bostock R, Dehesh K. Fatty acids and early detection of pathogens. Curr Opin Plant Biol. 2013;16:520-6 pubmed publisher
    ..various biological contexts, including plant-pathogen interactions and stress network signaling, is needed to fully understand fatty acids as regulatory signals that transcend their established role in membrane structure and function.
  14. Barnett J, Blindauer C, Kassaar O, Khazaipoul S, Martin E, Sadler P, et al. Allosteric modulation of zinc speciation by fatty acids. Biochim Biophys Acta. 2013;1830:5456-64 pubmed publisher
    ..of blood plasma and is responsible for the circulatory transport of a range of small molecules that include fatty acids, hormones, metal ions and drugs...
  15. den Besten G, van Eunen K, Groen A, Venema K, Reijngoud D, Bakker B. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res. 2013;54:2325-40 pubmed publisher
    Short-chain fatty acids (SCFAs), the end products of fermentation of dietary fibers by the anaerobic intestinal microbiota, have been shown to exert multiple beneficial effects on mammalian energy metabolism...
  16. Yaemsiri S, Sen S, Tinker L, Robinson W, Evans R, Rosamond W, et al. Serum fatty acids and incidence of ischemic stroke among postmenopausal women. Stroke. 2013;44:2710-7 pubmed publisher
    Although studies have linked types of fatty acids with coronary heart disease, data on individual fatty acids and risk of ischemic stroke are limited...
  17. Krag K, Poulsen N, Larsen M, Larsen L, Janss L, Buitenhuis B. Genetic parameters for milk fatty acids in Danish Holstein cattle based on SNP markers using a Bayesian approach. BMC Genet. 2013;14:79 pubmed publisher
    For several years, in human nutrition there has been a focus on the proportion of unsaturated fatty acids (UFA) and saturated fatty acids (SFA) found in bovine milk...
  18. Calder P. Long chain fatty acids and gene expression in inflammation and immunity. Curr Opin Clin Nutr Metab Care. 2013;16:425-33 pubmed publisher
    The purpose of this review is to discuss recent studies reporting on the influence of fatty acids on gene expression in relation to inflammation and immune responses...
  19. de Kroon A, Rijken P, De Smet C. Checks and balances in membrane phospholipid class and acyl chain homeostasis, the yeast perspective. Prog Lipid Res. 2013;52:374-94 pubmed publisher
    ..Based on the reviewed studies, molecular species selectivity of the lipid metabolic enzymes, and mass action in acyl-CoA metabolism are put forward as important intrinsic contributors to membrane lipid homeostasis. ..
  20. Tein I. Disorders of fatty acid oxidation. Handb Clin Neurol. 2013;113:1675-88 pubmed publisher
    ..The identification of serum acylcarnitines by electrospray ionization-tandem mass spectrometry of dried blood spots on filter paper in newborn screening programs has significantly enhanced the early recognition of these disorders. ..
  21. Oliveira Junior S, Padovani C, Rodrigues S, Silva N, Martinez P, Campos D, et al. Extensive impact of saturated fatty acids on metabolic and cardiovascular profile in rats with diet-induced obesity: a canonical analysis. Cardiovasc Diabetol. 2013;12:65 pubmed publisher
    ..analyzed the correlation between ingested macronutrients (including sucrose and saturated and unsaturated fatty acids) plus body adiposity and metabolic, hormonal, and cardiovascular effects in rats with diet-induced obesity...
  22. Mbesse Kongbonga Y, Ghalila H, Onana M, Ben Lakhdar Z. Classification of vegetable oils based on their concentration of saturated fatty acids using laser induced breakdown spectroscopy (LIBS). Food Chem. 2014;147:327-31 pubmed publisher
    ..as a classification, a single parameter that could be used to determine the concentration of saturated fatty acids of vegetable oils...
  23. Waugh C, Nichols P, Schlabach M, Noad M, Bengtson Nash S. Vertical distribution of lipids, fatty acids and organochlorine contaminants in the blubber of southern hemisphere humpback whales (Megaptera novaeangliae). Mar Environ Res. 2014;94:24-31 pubmed publisher
    ..through the blubber mantle may, however, not be homogenous and could reflect any dissemination of lipids and fatty acids (FAs)...
  24. Sparks L, Bosma M, Brouwers B, van de Weijer T, Bilet L, Schaart G, et al. Reduced incorporation of fatty acids into triacylglycerol in myotubes from obese individuals with type 2 diabetes. Diabetes. 2014;63:1583-1593 pubmed publisher
    ..99 ± 0.17 nmol/mg protein; T2D: 0.53 ± 0.07 nmol/mg protein; P = 0.03) and incorporation of fatty acids (FAs) into triacylglycerol (TAG) (controls: 0.45 ± 0.13 nmol/mg protein; T2D: 0.11 ± 0...
  25. Mulder K, Ferdinands A, Richardson K, Innis S. Sources of trans and saturated fatty acids in the diets of Vancouver children. Can J Diet Pract Res. 2013;74:7-13 pubmed
    Amounts and sources of trans fatty acids (TFA) and saturated fatty acids (SFA) were examined in the diets of children aged five to six years after changes in TFA in Canadian foods...
  26. Schwenke D, Foreyt J, Miller E, Reeves R, Vitolins M. Plasma concentrations of trans fatty acids in persons with type 2 diabetes between September 2002 and April 2004. Am J Clin Nutr. 2013;97:862-71 pubmed publisher
    transFatty acids (TFAs) increase cardiovascular disease risk. TFAs and polyunsaturated fatty acids (PUFAs) in the food supply may be declining with reciprocal increases in cis-monounsaturated fatty acids (MUFAs) and saturated fatty acids ..
  27. Koyuncu E, Purdy J, Rabinowitz J, Shenk T. Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny. PLoS Pathog. 2013;9:e1003333 pubmed publisher
    ..acid analysis with ¹³C-labeling revealed that malonyl-CoA is consumed by elongases to produce very long chain fatty acids, generating an approximately 8-fold increase in C26-C34 fatty acid tails in infected cells...
  28. Bogen C, Klassen V, Wichmann J, La Russa M, Doebbe A, Grundmann M, et al. Identification of Monoraphidium contortum as a promising species for liquid biofuel production. Bioresour Technol. 2013;133:622-6 pubmed publisher
    ..Neutral lipid production was strongly induced in M. contortum by nitrogen deficient conditions and accumulated to up to 20.4±2.2% of DW. ..
  29. Olpin S. Pathophysiology of fatty acid oxidation disorders and resultant phenotypic variability. J Inherit Metab Dis. 2013;36:645-58 pubmed publisher
    b>Fatty acids are a major fuel for the body and fatty acid oxidation is particularly important during fasting, sustained aerobic exercise and stress...
  30. Pelser C, Mondul A, Hollenbeck A, Park Y. Dietary fat, fatty acids, and risk of prostate cancer in the NIH-AARP diet and health study. Cancer Epidemiol Biomarkers Prev. 2013;22:697-707 pubmed publisher
    Observational studies report inconsistent associations of fat and fatty acids with prostate cancer...
  31. Gustafsson S, Wallenius A, Zackrisson H, Popova D, Plym Forshell L, Jacobsson S. Effects of cannabinoids and related fatty acids upon the viability of P19 embryonal carcinoma cells. Arch Toxicol. 2013;87:1939-1951 pubmed publisher
    ..The endogenous CB anandamide showed similar potency and efficacy as structurally related polyunsaturated fatty acids with no reported activity at the CB receptors...
  32. Huang H, McIntosh A, Martin G, Landrock K, Landrock D, Gupta S, et al. Structural and functional interaction of fatty acids with human liver fatty acid-binding protein (L-FABP) T94A variant. FEBS J. 2014;281:2266-83 pubmed publisher
    ..or only slightly altered L-FABP binding affinities for saturated, monounsaturated or polyunsaturated long chain fatty acids, nor did it change the affinity for intermediates of triglyceride synthesis...
  33. Olsen R, Cornelius N, Gregersen N. Genetic and cellular modifiers of oxidative stress: what can we learn from fatty acid oxidation defects?. Mol Genet Metab. 2013;110 Suppl:S31-9 pubmed publisher
  34. Colman E, Khafipour E, Vlaeminck B, De Baets B, Plaizier J, Fievez V. Grain-based versus alfalfa-based subacute ruminal acidosis induction experiments: Similarities and differences between changes in milk fatty acids. J Dairy Sci. 2013;96:4100-11 pubmed publisher
    ..Nevertheless, feed characteristics (low in structural fiber vs. high in starch) also affected the milk FA profile and, as such, both effects should be taken into account when subacute acidosis occurs. ..
  35. Dussert S, Guerin C, Andersson M, Joet T, Tranbarger T, Pizot M, et al. Comparative transcriptome analysis of three oil palm fruit and seed tissues that differ in oil content and fatty acid composition. Plant Physiol. 2013;162:1337-58 pubmed publisher
    ..While lauric acid predominates in endosperm oil, the major fatty acids (FAs) of mesocarp oil are palmitic and oleic acids...
  36. Bassett J, Severi G, Hodge A, Macinnis R, Gibson R, Hopper J, et al. Plasma phospholipid fatty acids, dietary fatty acids and prostate cancer risk. Int J Cancer. 2013;133:1882-91 pubmed publisher
    Animal and experimental studies have demonstrated that long-chain n-3 fatty acids inhibit the development of prostate cancer, whereas n-6 fatty acids might promote it...
  37. Melton E, Cerny R, DiRusso C, Black P. Overexpression of human fatty acid transport protein 2/very long chain acyl-CoA synthetase 1 (FATP2/Acsvl1) reveals distinct patterns of trafficking of exogenous fatty acids. Biochem Biophys Res Commun. 2013;440:743-8 pubmed publisher
    ..in fatty acid transport proceeding through vectorial acylation and in the activation of very long chain fatty acids, branched chain fatty acids and secondary bile acids...
  38. Kuliaviene I, Gulbinas A, Cremers J, Pundzius J, Kupcinskas L, Dambrauskas Z, et al. Fatty acids of erythrocyte membrane in acute pancreatitis patients. World J Gastroenterol. 2013;19:5678-84 pubmed publisher
    ..To evaluate changes in the fatty acid composition of erythrocyte membrane phospholipids during severe and mild acute pancreatitis (AP) of alcoholic and nonalcoholic etiology...
  39. Payet L, Pineau L, Snyder E, Colas J, Moussa A, Vannier B, et al. Saturated fatty acids alter the late secretory pathway by modulating membrane properties. Traffic. 2013;14:1228-41 pubmed publisher
    Saturated fatty acids (SFA) have been reported to alter organelle integrity and function in many cell types, including muscle and pancreatic ?-cells, adipocytes, hepatocytes and cardiomyocytes...
  40. Zaidi N, Lupien L, Kuemmerle N, Kinlaw W, Swinnen J, Smans K. Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids. Prog Lipid Res. 2013;52:585-9 pubmed publisher
    ..Depending on the tumor type, tumor cells synthesize up to 95% of saturated and mono-unsaturated fatty acids (FA) de novo in spite of sufficient dietary lipid supply...
  41. Long E, Hellberg K, Foncea R, Hertzel A, Suttles J, Bernlohr D. Fatty acids induce leukotriene C4 synthesis in macrophages in a fatty acid binding protein-dependent manner. Biochim Biophys Acta. 2013;1831:1199-207 pubmed
    ..as leukotriene C4 (LTC4) and 5-, 12-, and 15-hydroxyeicosatetraenoic acid (HETE) suggesting the hypothesis that fatty acids may stimulate eicosanoid synthesis...
  42. Ding J, Loizides Mangold U, Rando G, Zoete V, Michielin O, Reddy J, et al. The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain fatty acids. Cell Rep. 2013;5:248-58 pubmed publisher
    ..Although essential, these mechanisms are incompletely defined. Here, we report that medium-chain fatty acids contained in coconut oil, a major source of dietary fat, induce the liver ?-oxidation genes Cyp4a10 and Cyp4a14 ..
  43. Elamin E, Masclee A, Dekker J, Pieters H, Jonkers D. Short-chain fatty acids activate AMP-activated protein kinase and ameliorate ethanol-induced intestinal barrier dysfunction in Caco-2 cell monolayers. J Nutr. 2013;143:1872-81 pubmed publisher
    Short-chain fatty acids (SCFAs) have been shown to promote intestinal barrier function, but their protective effects against ethanol-induced intestinal injury and underlying mechanisms remain essentially unknown...
  44. Sabetta W, Blanco A, Zelasco S, Lombardo L, Perri E, Mangini G, et al. Fad7 gene identification and fatty acids phenotypic variation in an olive collection by EcoTILLING and sequencing approaches. Plant Physiol Biochem. 2013;69:1-8 pubmed publisher
    ..Only three haplotypes were identified among the 96 analysed cultivars, highlighting the strong degree of conservation of this gene. ..
  45. Liu H, Qiu Y, Mu Y, Zhang X, Liu L, Hou X, et al. A high ratio of dietary n-3/n-6 polyunsaturated fatty acids improves obesity-linked inflammation and insulin resistance through suppressing activation of TLR4 in SD rats. Nutr Res. 2013;33:849-58 pubmed publisher
    Dietary ratios of n-3/n-6 polyunsaturated fatty acids (PUFAs) have been implicated in controlling markers of metabolic disorders, including obesity, insulin resistance (IR), inflammation, and lipid profiles, which are also presumed to be ..
  46. Nestel P, Straznicky N, Mellett N, Wong G, De Souza D, Tull D, et al. Specific plasma lipid classes and phospholipid fatty acids indicative of dairy food consumption associate with insulin sensitivity. Am J Clin Nutr. 2014;99:46-53 pubmed publisher
    ..of dairy foods may reduce risk of type 2 diabetes on the basis of evidence of raised circulating ruminant fatty acids. We determined whether certain phospholipid species and fatty acids that are associated with full-fat dairy ..
  47. Kamphorst J, Cross J, Fan J, de Stanchina E, Mathew R, White E, et al. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci U S A. 2013;110:8882-7 pubmed publisher
    Cancer cell growth requires fatty acids to replicate cellular membranes. The kinase Akt is known to up-regulate fatty acid synthesis and desaturation, which is carried out by the oxygen-consuming enzyme stearoyl-CoA desaturase (SCD)1...
  48. Banas W, Sánchez García A, Banas A, Stymne S. Activities of acyl-CoA:diacylglycerol acyltransferase (DGAT) and phospholipid:diacylglycerol acyltransferase (PDAT) in microsomal preparations of developing sunflower and safflower seeds. Planta. 2013;237:1627-36 pubmed publisher
    ..No DAG:DAG transacylase activity could be detected in the microsomal preparations...
  49. Bernardi J, Ferreira C, Senter G, Krolow R, de Aguiar B, Portella A, et al. Early life stress interacts with the diet deficiency of omega-3 fatty acids during the life course increasing the metabolic vulnerability in adult rats. PLoS ONE. 2013;8:e62031 pubmed publisher
    Early stress can cause metabolic disorders in adulthood. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) deficiency has also been linked to the development of metabolic disorders...
  50. Böhm T, Berger H, Nejabat M, Riegler T, Kellner F, Kuttke M, et al. Food-derived peroxidized fatty acids may trigger hepatic inflammation: a novel hypothesis to explain steatohepatitis. J Hepatol. 2013;59:563-70 pubmed publisher
    ..Corn oil containing peroxidized fatty acids was administered to rats by gavage for 6 days...
  51. Le Foll C, Dunn Meynell A, Musatov S, Magnan C, Levin B. FAT/CD36: a major regulator of neuronal fatty acid sensing and energy homeostasis in rats and mice. Diabetes. 2013;62:2709-16 pubmed publisher
    Hypothalamic "metabolic-sensing" neurons sense glucose and fatty acids (FAs) and play an integral role in the regulation of glucose, energy homeostasis, and the development of obesity and diabetes...
  52. Kim S, Rhee M. Marked synergistic bactericidal effects and mode of action of medium-chain fatty acids in combination with organic acids against Escherichia coli O157:H7. Appl Environ Microbiol. 2013;79:6552-60 pubmed publisher
    The aim of this study was to examine the synergistic bactericidal effects of medium-chain fatty acids (MCFAs; caprylic, capric, and lauric acid) and organic acids (OAs; acetic, lactic, malic, and citric acid) against Escherichia coli ..
  53. Masi L, Rodrigues A, Curi R. Fatty acids regulation of inflammatory and metabolic genes. Curr Opin Clin Nutr Metab Care. 2013;16:418-24 pubmed publisher
    b>Fatty acids influence human health and diseases in various ways. In recent years, much work has been carried out to elucidate the mechanisms by which dietary fatty acids control short-term and long-term cellular functions...