oocyte donation


Summary: Transfer of preovulatory oocytes from donor to a suitable host. Oocytes are collected, fertilized in vitro, and transferred to a host that can be human or animal.

Top Publications

  1. Galindo A, Bodri D, Guillén J, Colodron M, Vernaeve V, Coll O. Triggering with HCG or GnRH agonist in GnRH antagonist treated oocyte donation cycles: a randomised clinical trial. Gynecol Endocrinol. 2009;25:60-6 pubmed publisher
    ..outcome after inducing the final oocyte maturation with hCG or GnRH agonist in GnRH-antagonist treated oocyte donation (OD) cycles...
  2. Andersen A, Goossens V, Ferraretti A, Bhattacharya S, Felberbaum R, de Mouzon J, et al. Assisted reproductive technology in Europe, 2004: results generated from European registers by ESHRE. Hum Reprod. 2008;23:756-71 pubmed publisher
    ..Compared with earlier years, the reported number of ART cycles in Europe increased and the pregnancy rates increased marginally, even though fewer embryos were transferred and the multiple delivery rates were reduced. ..
  3. Le Ray C, Scherier S, Anselem O, Marszalek A, Tsatsaris V, Cabrol D, et al. Association between oocyte donation and maternal and perinatal outcomes in women aged 43 years or older. Hum Reprod. 2012;27:896-901 pubmed publisher
    ..an increasing number of women delay conception until the age of 40, and some must resort to IVF with oocyte donation. Our objective was to study the association between IVF, both with and without oocyte donation, and maternal ..
  4. Yee S, Blyth E, Tsang A. Views of donors and recipients regarding disclosure to children following altruistic known oocyte donation. Reprod Biomed Online. 2011;23:851-9 pubmed publisher
    ..limited research evidence on disclosure to children in both donor and recipient families following known oocyte donation. This paper reports on a Canadian study of the views of 15 women who had altruistically donated oocytes to a ..
  5. Martinez Conejero J, Morgan M, Montesinos M, Fortuño S, Meseguer M, Simon C, et al. Adenomyosis does not affect implantation, but is associated with miscarriage in patients undergoing oocyte donation. Fertil Steril. 2011;96:943-50 pubmed publisher
    ..Retrospective matched cohort study of the impact of adenomyosis on oocyte donation (OD) outcome. University-affiliated infertility clinic (2005-2009)...
  6. Isaksson S, Skoog Svanberg A, Sydsjo G, Thurin Kjellberg A, Karlström P, Solensten N, et al. Two decades after legislation on identifiable donors in Sweden: are recipient couples ready to be open about using gamete donation?. Hum Reprod. 2011;26:853-60 pubmed publisher
    ..Recipient couples may benefit from more information and support regarding parenthood after gamete donation. Further studies are required to follow-up on the future parents' actual disclosure behaviour directed to offspring. ..
  7. Levine A. The oversight and practice of oocyte donation in the United States, United Kingdom and Canada. HEC Forum. 2011;23:15-30 pubmed publisher
    ..This paper examines the oversight and practice of oocyte donation in Canada, the United Kingdom and the United States to examine how policy choices have influenced the ..
  8. Krieg S, Henne M, Westphal L. Obstetric outcomes in donor oocyte pregnancies compared with advanced maternal age in in vitro fertilization pregnancies. Fertil Steril. 2008;90:65-70 pubmed
  9. Söderström Anttila V, Sälevaara M, Suikkari A. Increasing openness in oocyte donation families regarding disclosure over 15 years. Hum Reprod. 2010;25:2535-42 pubmed publisher
    Worldwide there is an increasing number of families created by oocyte donation (OD)...

More Information


  1. Guillou J, Séjourné N, Chabrol H. [Pregnancy following anonymous oocyte donation: Experience and feelings]. Gynecol Obstet Fertil. 2009;37:410-4 pubmed publisher
    This qualitative study focuses on feelings of women who receive an anonymous oocyte donation. A heterogeneous group of 12 women who were mothers or pregnant following a oocyte donation or who were waiting for a donation took part in the ..
  2. van der Hoorn M, Lashley E, Bianchi D, Claas F, Schonkeren C, Scherjon S. Clinical and immunologic aspects of egg donation pregnancies: a systematic review. Hum Reprod Update. 2010;16:704-12 pubmed publisher
    ..Knowledge of the immune system in ED pregnancies has broader significance, as it may also give insight into immunologic aspects of tolerance in solid organ transplantation. ..
  3. Soares S, Velasco J, Fernandez M, Bosch E, Remohi J, Pellicer A, et al. Clinical factors affecting endometrial receptiveness in oocyte donation cycles. Fertil Steril. 2008;89:491-501 pubmed publisher
    ..the oocyte recipient (other than those associated with uterine cavity abnormalities) on the outcome of oocyte donation cycles. Review of the literature...
  4. Vernaeve V, Bodri D, Colodron M, Vidal R, Durban M, Coll O. Endometrial receptivity after oocyte donation in recipients with a history of chemotherapy and/or radiotherapy. Hum Reprod. 2007;22:2863-7 pubmed
    Information is scarce regarding the outcome of oocyte donation (OD) in patients with a history of cancer treatment. Therefore, we conducted a matched controlled analysis on the outcome of OD in these recipients...
  5. Shehab D, Duff J, Pasch L, Mac Dougall K, Scheib J, Nachtigall R. How parents whose children have been conceived with donor gametes make their disclosure decision: contexts, influences, and couple dynamics. Fertil Steril. 2008;89:179-87 pubmed
    ..Although the majority of couples were in initial agreement about disclosure, for many the disclosure decision was a complex, negotiated process reflecting a wide range of influences and contexts. ..
  6. Bodri D, Guillén J, Lopez M, Vernaeve V, Coll O. Racial disparity in oocyte donation outcome: a multiethnic, matched cohort study. Hum Reprod. 2010;25:436-42 pubmed publisher
    ..To our knowledge no data currently are available on the effect of race on oocyte donation outcome...
  7. Walsh A, Omar A, Collins G, Murray G, Walsh D, Salma U, et al. Application of EU tissue and cell directive screening protocols to anonymous oocyte donors in western Ukraine: data from an Irish IVF programme. J Obstet Gynaecol. 2010;30:613-6 pubmed publisher
    Anonymous oocyte donation in the EU proceeds only after rigorous screening designed to ensure gamete safety...
  8. Sole M, Santalo J, Boada M, Clua E, Rodriguez I, Martinez F, et al. How does vitrification affect oocyte viability in oocyte donation cycles? A prospective study to compare outcomes achieved with fresh versus vitrified sibling oocytes. Hum Reprod. 2013;28:2087-92 pubmed publisher
    How does vitrification affect oocyte viability? Vitrification does not affect oocyte viability in oocyte donation cycles. Oocyte vitrification is performed routinely and successfully in IVF and oocyte donation programs...
  9. Melo M, Busso C, Bellver J, Alama P, Garrido N, Meseguer M, et al. GnRH agonist versus recombinant HCG in an oocyte donation programme: a randomized, prospective, controlled, assessor-blind study. Reprod Biomed Online. 2009;19:486-92 pubmed
    ..Moreover, this regime effectively eliminates the risk of OHSS in this group of women. ..
  10. Purewal S, van den Akker O. A study of the effect of message framing on oocyte donation. Hum Reprod. 2009;24:3136-43 pubmed publisher
    ..the effect of gain- and loss-framed messages on British and South East Asian women's intentions towards oocyte donation and to examine whether the components of the theory of planned behaviour influenced the relationship between ..
  11. Eitan Schiller Y, Seidman D. [Sperm or oocyte donation: the dynamics of making the decision regarding the method and timing of disclosure of information to the sibling]. Harefuah. 2009;148:251-5, 275 pubmed
  12. Purewal S, van den Akker O. Systematic review of oocyte donation: investigating attitudes, motivations and experiences. Hum Reprod Update. 2009;15:499-515 pubmed publisher
    ..review were therefore to integrate the research findings regarding the psychosocial determinants of oocyte donation and extrapolate women's experiences of donation...
  13. Cruz M, Garrido N, Gadea B, Muñoz M, Pérez Cano I, Meseguer M. Oocyte insemination techniques are related to alterations of embryo developmental timing in an oocyte donation model. Reprod Biomed Online. 2013;27:367-75 pubmed publisher
    ..IVF or ICSI, influences embryo developmental kinetics by examining 1203 embryos from 178 couples undergoing oocyte donation with IVF or ICSI...
  14. Klatsky P, Delaney S, Caughey A, Tran N, Schattman G, Rosenwaks Z. The role of embryonic origin in preeclampsia: a comparison of autologous in vitro fertilization and ovum donor pregnancies. Obstet Gynecol. 2010;116:1387-92 pubmed publisher
    ..These findings inform future research and help counsel women using assisted reproductive technology. ..
  15. Cruz M, Gadea B, Garrido N, Pedersen K, Martínez M, Pérez Cano I, et al. Embryo quality, blastocyst and ongoing pregnancy rates in oocyte donation patients whose embryos were monitored by time-lapse imaging. J Assist Reprod Genet. 2011;28:569-73 pubmed publisher
    ..We analyzed 478 embryos from 60 couples undergoing oocyte donation were included in the study. All embryos retrieved from a patient were randomly distributed in the ES or SI...
  16. Carroll K, Waldby C. Informed consent and fresh egg donation for stem cell research. J Bioeth Inq. 2012;9:29-39 pubmed publisher
    ..We recommend that at least one full cycle of IVF be completed before approaching women to divert eggs away from their own fertility treatment. ..
  17. Meseguer M, Martínez Conejero J, O Connor J, Pellicer A, Remohi J, Garrido N. The significance of sperm DNA oxidation in embryo development and reproductive outcome in an oocyte donation program: a new model to study a male infertility prognostic factor. Fertil Steril. 2008;89:1191-9 pubmed
    ..Our aim with this work was to determine the relevance of sperm DNA oxidation on embryo quality in oocyte donation cycles. We prospectively studied pairs of oocyte donation cycles, i.e...
  18. Baylis F, McLeod C. The stem cell debate continues: the buying and selling of eggs for research. J Med Ethics. 2007;33:726-31 pubmed
  19. Hauzman E, Garcia Velasco J, Pellicer A. Oocyte donation and endometriosis: What are the lessons?. Semin Reprod Med. 2013;31:173-7 pubmed publisher
    ..b>Oocyte donation provides an interesting model to investigate reproductive outcome because factors affecting the oocytes are ..
  20. Hernandez E, Gómez Palomares J, Ricciarelli E. No room for cancellation, coasting, or ovarian hyperstimulation syndrome in oocyte donation cycles. Fertil Steril. 2009;91:1358-61 pubmed publisher
    ..2%) or severe (1%) ovarian hyperstimulation syndrome, while none of the IVF donor cycles that were triggered with the GnRH agonist presented ovarian hyperstimulation syndrome, needed coasting, or were cancelled...
  21. Nagy Z, Chang C, Shapiro D, Bernal D, Elsner C, Mitchell Leef D, et al. Clinical evaluation of the efficiency of an oocyte donation program using egg cryo-banking. Fertil Steril. 2009;92:520-6 pubmed publisher
    To evaluate the efficiency of oocyte donation cycles using egg "cryo-banking...
  22. Carter J, Applegarth L, Josephs L, Grill E, Baser R, Rosenwaks Z. A cross-sectional cohort study of infertile women awaiting oocyte donation: the emotional, sexual, and quality-of-life impact. Fertil Steril. 2011;95:711-6.e1 pubmed publisher
    To examine the emotional, sexual, physical, and quality-of-life (QOL) impact on infertile women awaiting oocyte donation. Cross-sectional cohort study. Cancer center and reproductive medicine center...
  23. Riggs R, Kimble T, Oehninger S, Bocca S, Zhao Y, Leader B, et al. Anti-Müllerian hormone serum levels predict response to controlled ovarian hyperstimulation but not embryo quality or pregnancy outcome in oocyte donation. Fertil Steril. 2011;95:410-2 pubmed publisher
  24. Waldby C, Carroll K. Egg donation for stem cell research: ideas of surplus and deficit in Australian IVF patients' and reproductive donors' accounts. Sociol Health Illn. 2012;34:513-28 pubmed publisher
    ..Such perspectives are particularly valuable because IVF patients form a major recruitment group for oocyte donation for research, and because patients and donors have direct experience of the medical procedures involved...
  25. Berger B, Phillips J. Pregnancy outcomes in oocyte donation recipients: vaginal gel versus intramuscular injection progesterone replacement. J Assist Reprod Genet. 2012;29:237-42 pubmed publisher
    ..Pregnancy outcomes were comparable for progesterone replacement with vaginal gel and intramuscular progesterone in an oocyte donation program.
  26. Haimes E, Taylor K, Turkmendag I. Eggs, ethics and exploitation? Investigating women's experiences of an egg sharing scheme. Sociol Health Illn. 2012;34:1199-214 pubmed publisher
    ..Nonetheless, these freely made decisions do not necessarily take place under circumstances of their choosing. We discuss the implications of this for egg provision in general and for understandings of exploitation. ..
  27. Klitzman R, Sauer M. Payment of egg donors in stem cell research in the USA. Reprod Biomed Online. 2009;18:603-8 pubmed
  28. Barker M, Boehnlein L, Kovacs P, Lindheim S. Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles. J Assist Reprod Genet. 2009;26:243-9 pubmed publisher
    To study the effect of endometrial thickness (ET) and echogenic pattern (EP) in oocyte donation cycles upon pregnancy outcomes. Seventy-nine cycles resulting in blastocyst embryo transfer were evaluated...
  29. Lampic C, Skoog Svanberg A, Sydsjo G. Attitudes towards gamete donation among IVF doctors in the Nordic countries-are they in line with national legislation?. J Assist Reprod Genet. 2009;26:231-8 pubmed publisher
    ..There are discrepancies between IVF doctors' attitudes towards gamete donation and national legislation in four Nordic countries. Negative attitudes towards disclosure to offspring may counteract legislative intentions. ..
  30. Clua E, Tur R, Coroleu B, Boada M, Rodriguez I, Barri P, et al. Elective single-embryo transfer in oocyte donation programmes: Should it be the rule?. Reprod Biomed Online. 2012;25:642-8 pubmed publisher
    ..from the same stimulated cycle) between single-embryo transfer (SET) and double-embryo transfer (DET) in an oocyte donation programme...
  31. Roxland B. New York State's landmark policies on oversight and compensation for egg donation to stem cell research. Regen Med. 2012;7:397-408 pubmed publisher
    ..The multifaceted deliberation process and comprehensive policies may serve as a model for other states and countries considering the issue of oocyte donor compensation. ..
  32. Pecks U, Maass N, Neulen J. Oocyte donation: a risk factor for pregnancy-induced hypertension: a meta-analysis and case series. Dtsch Arztebl Int. 2011;108:23-31 pubmed publisher
    In 2008 and 2009, the authors saw in their institution three women who had undergone oocyte donation and went on to develop severe de novo hypertension before the 26(th) week of gestation, with values above 180/110 mm Hg...
  33. Marchaudon V, Piccardino O, Dufour P, Subtil D, Deruelle P. [Being pregnant over 45 after oocyte donation in a foreign country. A wonder of medicine or an ethical transgression?]. Gynecol Obstet Fertil. 2007;35:1235-8 pubmed
    ..For women who still want to be pregnant, oocyte donation in a foreign country may offer a solution...
  34. Roberts C, Throsby K. Paid to share: IVF patients, eggs and stem cell research. Soc Sci Med. 2008;66:159-69 pubmed
    ..Our analysis highlights the need for innovative social, ethical and political consideration of egg sharing for stem cell research. ..
  35. Sheffer Mimouni G, Mashiach S, Dor J, Levran D, Seidman D. Factors influencing the obstetric and perinatal outcome after oocyte donation. Hum Reprod. 2002;17:2636-40 pubmed
    We evaluated interactions between perinatal outcome after oocyte donation and various maternal factors. The study included 134 parturients after oocyte donation. Data were collected from medical files and personal interviews...
  36. Levi A, Drews M, Bergh P, Miller B, Scott R. Controlled ovarian hyperstimulation does not adversely affect endometrial receptivity in in vitro fertilization cycles. Fertil Steril. 2001;76:670-4 pubmed
    ..Exposure of the developing endometrium to controlled ovarian hyperstimulation during IVF cycles does not inhibit embryo implantation or affect pregnancy and delivery rates. ..
  37. Golombok S, Lycett E, Maccallum F, Jadva V, Murray C, Rust J, et al. Parenting infants conceived by gamete donation. J Fam Psychol. 2004;18:443-52 pubmed
    ..It was concluded that infants conceived by egg or sperm donation did not appear to be at risk for parenting difficulties. ..
  38. Söderström Anttila V. Pregnancy and child outcome after oocyte donation. Hum Reprod Update. 2001;7:28-32 pubmed
    During the last decade oocyte donation has been highly successful for treating women previously thought to be hopelessly infertile...
  39. Thompson C. Why we should, in fact, pay for egg donation. Regen Med. 2007;2:203-9 pubmed
    ..I then suggest replacing the question of compensation with the question of harm mitigation as the central donor protection issue. ..
  40. Holzer H, Scharf E, Chian R, Demirtas E, Buckett W, Tan S. In vitro maturation of oocytes collected from unstimulated ovaries for oocyte donation. Fertil Steril. 2007;88:62-7 pubmed
    To assess the role of immature oocyte collection from unstimulated ovaries as a potential source of oocyte donation. Prospective cohort study. A tertiary, university-based, in vitro fertilization center...
  41. Budak E, Garrido N, Soares S, Melo M, Meseguer M, Pellicer A, et al. Improvements achieved in an oocyte donation program over a 10-year period: sequential increase in implantation and pregnancy rates and decrease in high-order multiple pregnancies. Fertil Steril. 2007;88:342-9 pubmed
    To compare outcome parameters and cumulative pregnancy rates (PRs) in oocyte donation cycles over a period of 10 years. Retrospective study. University-affiliated assisted reproductive technology program...
  42. Pena J, Chang P, Chan L, Zeitoun K, Thornton M, Sauer M. Supraphysiological estradiol levels do not affect oocyte and embryo quality in oocyte donation cycles. Hum Reprod. 2002;17:83-7 pubmed
    ..study aim was to determine whether supraphysiological estradiol (E(2)) levels reduce oocyte/embryo quality in oocyte donation cycles...
  43. Klein J, Sauer M. Oocyte donation. Best Pract Res Clin Obstet Gynaecol. 2002;16:277-91 pubmed
    b>Oocyte donation affords women with ovarian failure, advanced reproductive age, heritable conditions or recurrent implantation failure the ability to conceive. Recipients must be medically screened carefully prior to attempting pregnancy...
  44. Bellver J, Rossal L, Bosch E, Zúñiga A, Corona J, Meléndez F, et al. Obesity and the risk of spontaneous abortion after oocyte donation. Fertil Steril. 2003;79:1136-40 pubmed
    To determine whether obesity increases the risk of spontaneous abortion. Retrospective study. Oocyte donation program at the Instituto Valenciano de Infertilidad in Spain...
  45. Kolibianakis E, Zikopoulos K, Camus M, Tournaye H, Van Steirteghem A, Devroey P. Modified natural cycle for IVF does not offer a realistic chance of parenthood in poor responders with high day 3 FSH levels, as a last resort prior to oocyte donation. Hum Reprod. 2004;19:2545-9 pubmed
    ..to evaluate the use of the modified natural cycle (MNC) for IVF in poor responders as a last resort prior to oocyte donation. Thirty-two patients with a regular menstrual cycle, FSH levels on day 3 of the cycle >12 IU/l and one or ..
  46. Bodri D, Vernaeve V, Figueras F, Vidal R, Guillen J, Coll O. Oocyte donation in patients with Turner's syndrome: a successful technique but with an accompanying high risk of hypertensive disorders during pregnancy. Hum Reprod. 2006;21:829-32 pubmed
    Few data are available on pregnancy rate and obstetrical outcome after oocyte donation in Turner's syndrome patients. We conducted a retrospective analysis on the outcome of this subgroup...
  47. Borini A, Dal Prato L, Bianchi L, Violini F, Cattoli M, Flamigni C. Effect of duration of estradiol replacement on the outcome of oocyte donation. J Assist Reprod Genet. 2001;18:185-90 pubmed
    ..Endometrial receptivity is tolerant to a wide duration of E2 treatment (until 2 months), while waiting for oocytes available for donation, but best results are achieved with a treatment range of 11 to about 40 days. ..
  48. Mac Dougall K, Becker G, Scheib J, Nachtigall R. Strategies for disclosure: how parents approach telling their children that they were conceived with donor gametes. Fertil Steril. 2007;87:524-33 pubmed
    ..Parents wished for more peer and/or professional support and guidance to assist them with disclosure, not only initially but continuing long after their children were born. ..
  49. Stojkovic M, Stojkovic P, Leary C, Hall V, Armstrong L, Herbert M, et al. Derivation of a human blastocyst after heterologous nuclear transfer to donated oocytes. Reprod Biomed Online. 2005;11:226-31 pubmed
    ..However, if the promise of this new science is to achieve its potential in the foreseeable future, it will be necessary to identify new sources of oocytes that can be used immediately after retrieval. ..
  50. Wattanakumtornkul S, Damario M, Stevens Hall S, Thornhill A, Tummon I. Body mass index and uterine receptivity in the oocyte donation model. Fertil Steril. 2003;80:336-40 pubmed
    ..A tertiary referral center. Ninety-seven consecutive first-cycle recipients of anonymous oocyte donation. After programmed hormone replacement, recipients had transfer of embryos derived from oocyte donation...
  51. Sampaio M, Geber S. Births after transfer of zona-free blastocysts in oocyte donation cycles. J Assist Reprod Genet. 2001;18:156-9 pubmed
    b>Oocyte donation is a well-established method of assisted reproduction for women with irreversible infertility and with previous implantation failures after in vitro fertilization...
  52. Mirkin S, Gimeno T, Bovea C, Stadtmauer L, Gibbons W, Oehninger S. Factors associated with an optimal pregnancy outcome in an oocyte donation program. J Assist Reprod Genet. 2003;20:400-8 pubmed
    ..variables that may have a significant impact on pregnancy outcome in order to optimize results of an oocyte donation program...
  53. Moomjy M, Cholst I, Mangieri R, Rosenwaks Z. Oocyte donation: insights into implantation. Fertil Steril. 1999;71:15-21 pubmed
    ..Clinical study. Academic tertiary care infertility clinic. A total of 370 recipients. Fresh ET following oocyte donation in a hormone replacement cycle...