reperfusion

Summary

Summary: Restoration of blood supply to tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. It is primarily a procedure for treating infarction or other ischemia, by enabling viable ischemic tissue to recover, thus limiting further necrosis. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing REPERFUSION INJURY.

Top Publications

  1. t Hart N, van der Plaats A, Moers C, Leuvenink H, Wiersema Buist J, Verkerke G, et al. Development of the isolated dual perfused rat liver model as an improved reperfusion model for transplantation research. Int J Artif Organs. 2006;29:219-27 pubmed
    ..b>Reperfusion is performed in a controlled setting, however, via the portal vein only...
  2. Ito Y, Ohkubo T, Asano Y, Hattori K, Shimazu T, Yamazato M, et al. Nitric oxide production during cerebral ischemia and reperfusion in eNOS- and nNOS-knockout mice. Curr Neurovasc Res. 2010;7:23-31 pubmed
    ..changes to hippocampal CA1 neurons in eNOS knockout (-/-) mice and nNOS (-/-) mice during cerebral ischemia and reperfusion. NO production was continuously monitored by in vivo microdialysis...
  3. Khatri P, Yeatts S, Mazighi M, Broderick J, Liebeskind D, Demchuk A, et al. Time to angiographic reperfusion and clinical outcome after acute ischaemic stroke: an analysis of data from the Interventional Management of Stroke (IMS III) phase 3 trial. Lancet Neurol. 2014;13:567-74 pubmed publisher
    ..Late reperfusion of tissue that was no longer salvageable could be one explanation, as suggested by previous exploratory studies ..
  4. Saba L, Berritto D, Iacobellis F, Scaglione M, Castaldo S, Cozzolino S, et al. Acute arterial mesenteric ischemia and reperfusion: macroscopic and MRI findings, preliminary report. World J Gastroenterol. 2013;19:6825-33 pubmed publisher
    ..imaging (MRI) findings in an animal model of acute arterial mesenteric ischemia (AAMI) with and without reperfusion. In this study, 8 adult Sprague-Dawley rats underwent superior mesenteric artery (SMA) ligation and were then ..
  5. Jang B, Choi B, Kim J, Kim M, Sohn M, Suh S. Impairment of autophagic flux promotes glucose reperfusion-induced neuro2A cell death after glucose deprivation. PLoS ONE. 2013;8:e76466 pubmed publisher
    ..We previously reported that hypoglycemic neuronal death is triggered by glucose reperfusion after hypoglycemia rather than as a simple result of glucose deprivation...
  6. Lemmens R, Mlynash M, Straka M, Kemp S, Bammer R, Marks M, et al. Comparison of the response to endovascular reperfusion in relation to site of arterial occlusion. Neurology. 2013;81:614-8 pubmed publisher
    ..Mismatch and reperfusion status was assessed on MRI...
  7. Eilaghi A, Brooks J, d Esterre C, Zhang L, Swartz R, Lee T, et al. Reperfusion is a stronger predictor of good clinical outcome than recanalization in ischemic stroke. Radiology. 2013;269:240-8 pubmed publisher
    To assess the predictive value of reperfusion indices, recanalization, and important baseline clinical and radiologic scores for good clinical outcome prediction. The study was approved by the local research ethics board...
  8. Chen M, Sun H, Hu P, Wang C, Li B, Li S, et al. Activation of BKca channels mediates hippocampal neuronal death after reoxygenation and reperfusion. Mol Neurobiol. 2013;48:794-807 pubmed publisher
    ..of large-conductance Ca(2+)-activated K(+) channels (BKCa) mediates hypoxia/reoxygenation (H/R)- and ischemia/reperfusion (I/R)-induced neuronal apoptosis...
  9. Hirano T. Thrombolysis and hyperacute reperfusion therapy for stroke in renal patients. Contrib Nephrol. 2013;179:110-8 pubmed publisher
    ..60, 95% CI 0.45-0.81). Symptomatic intracranial hemorrhage occurred more in patients with CKD than without (OR 3.38, 95% CI 1.60-7.15). Risk of fatal outcome was also significantly higher in patients with CKD (OR 3.15, 95% CI 1.82-5.45). ..

More Information

Publications32

  1. Sun C, Nogueira R, Glenn B, Connelly K, Zimmermann S, Anda K, et al. "Picture to puncture": a novel time metric to enhance outcomes in patients transferred for endovascular reperfusion in acute ischemic stroke. Circulation. 2013;127:1139-48 pubmed publisher
    ..009). Delays in picture-to-puncture times for interhospital transfers reduce the probability of good outcomes among treated patients. Strategies to reduce such delays herald an opportunity for hospitals to improve patient outcomes. ..
  2. Connell B, Di Iorio P, Sayeed I, Ballerini P, Saleh M, Giuliani P, et al. Guanosine protects against reperfusion injury in rat brains after ischemic stroke. J Neurosci Res. 2013;91:262-72 pubmed publisher
    ..Using a collaborative approach, our groups examined the effects of guanosine (Guo) in response to ischemic reperfusion injury in vitro and in vivo...
  3. Liu D, Yuan F, Hu S, Diao F, Wu Y, Zong Y, et al. Endogenous nitric oxide induces activation of apoptosis signal-regulating kinase 1 via S-nitrosylation in rat hippocampus during cerebral ischemia-reperfusion. Neuroscience. 2013;229:36-48 pubmed publisher
    ..Here we reported ASK1 was activated by nitric oxide (NO) through S-nitrosylation during cerebral ischemia-reperfusion. The reagents that abrogate neuronal nitric oxide synthase (nNOS) activity such as nNOS inhibitor 7NI and N-..
  4. Lansberg M, Straka M, Kemp S, Mlynash M, Wechsler L, Jovin T, et al. MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study. Lancet Neurol. 2012;11:860-7 pubmed publisher
    ..to establish whether MRI can be used to identify patients who are most likely to benefit from endovascular reperfusion. In this prospective cohort study we consecutively enrolled patients scheduled to have endovascular treatment ..
  5. Feng J, Wang T, Li Q, Wu X, Qin X. RNA interference against repulsive guidance molecule A improves axon sprout and neural function recovery of rats after MCAO/reperfusion. Exp Neurol. 2012;238:235-42 pubmed publisher
    ..01). RGMa in rat brains after middle cerebral artery occlusion (MCAO) can be down-regulated by RNAi successfully, which may lead to improved axonal growth and neural anatomy plasticity, as well as neuron functional recovery. ..
  6. Sakai N, Van Sweringen H, Quillin R, Schuster R, Blanchard J, Burns J, et al. Interleukin-33 is hepatoprotective during liver ischemia/reperfusion in mice. Hepatology. 2012;56:1468-78 pubmed publisher
    ..study, we sought to determine whether IL-33 is an important regulator in the hepatic response to ischemia/reperfusion (I/R)...
  7. Barber P, Rushforth D, Agrawal S, Tuor U. Infrared optical imaging of matrix metalloproteinases (MMPs) up regulation following ischemia reperfusion is ameliorated by hypothermia. BMC Neurosci. 2012;13:76 pubmed publisher
    ..Images were acquired starting at 2 or 24 hours after reperfusion over the ipsilateral and contralateral cortex before and for 3 hours after, MMPSense750 was injected...
  8. Du H, Yang W, Chen L, Shen B, Peng C, Li H, et al. Emerging role of autophagy during ischemia-hypoxia and reperfusion in hepatocellular carcinoma. Int J Oncol. 2012;40:2049-57 pubmed publisher
    ..we report that autophagy plays a role in HCC cell proliferation in response to ischemia-hypoxia (I/H) and reperfusion and discuss its potential therapeutic implications...
  9. Oyaizu T, Fung S, Shiozaki A, Guan Z, Zhang Q, dos Santos C, et al. Src tyrosine kinase inhibition prevents pulmonary ischemia-reperfusion-induced acute lung injury. Intensive Care Med. 2012;38:894-905 pubmed publisher
    Pulmonary ischemia-reperfusion is a pathological process seen in several clinical conditions, including lung transplantation, cardiopulmonary bypass, resuscitation for circulatory arrest, atherosclerosis, and pulmonary embolism...
  10. Hong J, Koroleff D, Xia V, Chang C, Duarte S, Xu J, et al. Regulated hepatic reperfusion mitigates ischemia-reperfusion injury and improves survival after prolonged liver warm ischemia: a pilot study on a novel concept of organ resuscitation in a large animal model. J Am Coll Surg. 2012;214:505-15; discussion 515-6 pubmed publisher
    Ischemia-reperfusion injury (IRI) can occur during hepatic surgery and transplantation. IRI causes hepatic mitochondrial and microcirculatory impairment, resulting in acute liver dysfunction and failure...
  11. Nemeth N, Kiss F, Hever T, Brath E, Sajtos E, Furka I, et al. Hemorheological consequences of hind limb ischemia-reperfusion differs in normal and gonadectomized male and female rats. Clin Hemorheol Microcirc. 2012;50:197-211 pubmed publisher
    ..parameters (erythrocyte deformability and aggregation) sensitively change during and after ischemia-reperfusion (I/R), the question arises whether the hemorheological effects of I/R may show gender differences and further ..
  12. Jani A, Epperson E, Martin J, Pacic A, Ljubanovic D, Martin S, et al. Renal protection from prolonged cold ischemia and warm reperfusion in hibernating squirrels. Transplantation. 2011;92:1215-21 pubmed publisher
    ..the 13-lined ground squirrel (GS) cycles through repeated CI during torpor, followed by warm ischemia/reperfusion (WI) during interbout arousal (IBA)...
  13. Eltzschig H, Eckle T. Ischemia and reperfusion--from mechanism to translation. Nat Med. 2011;17:1391-401 pubmed publisher
    Ischemia and reperfusion-elicited tissue injury contributes to morbidity and mortality in a wide range of pathologies, including myocardial infarction, ischemic stroke, acute kidney injury, trauma, circulatory arrest, sickle cell disease ..
  14. Colín González A, Ortiz Plata A, Villeda Hernandez J, Barrera D, Molina Jijón E, Pedraza Chaverri J, et al. Aged garlic extract attenuates cerebral damage and cyclooxygenase-2 induction after ischemia and reperfusion in rats. Plant Foods Hum Nutr. 2011;66:348-54 pubmed publisher
    ..Animals were subjected to 1 h of ischemia plus 24 h of reperfusion. AGE (1.2 ml/kg weight, i.p.) was administered at onset of reperfusion...
  15. Chun K, Park Y, Kim J, Jang Y, Kim J, Kim J, et al. Comparison of 5 different remifentanil strategies against myocardial ischemia-reperfusion injury. J Cardiothorac Vasc Anesth. 2011;25:926-30 pubmed publisher
    ..remifentanil strategies (preconditioning, postconditioning, or continuous infusion) against myocardial ischemia-reperfusion injury. An in vitro experimental study using the Langendorff system. A university research laboratory...
  16. Mas E, Barden A, Corcoran T, Phillips M, Roberts L, Mori T. Effects of spinal or general anesthesia on F?-isoprostanes and isofurans during ischemia/reperfusion of the leg in patients undergoing knee replacement surgery. Free Radic Biol Med. 2011;50:1171-6 pubmed publisher
    ..Ischemia/reperfusion injury after release of the tourniquet initiates free radical-mediated oxidative stress...
  17. Shaafi S, Afrooz M, Hajipour B, Dadadshi A, Hosseinian M, Khodadadi A. Anti-oxidative effect of lipoic Acid in spinal cord ischemia/reperfusion. Med Princ Pract. 2011;20:19-22 pubmed publisher
    ..The aim of this research was to study the probable protective effect of LA in spinal ischemic/reperfusion (I/R) injury...
  18. Chen Y, Liu Z, Xie X. Hydrogen sulphide attenuates renal and cardiac injury after total hepatic ischemia and reperfusion. J Surg Res. 2010;164:e305-13 pubmed publisher
    There are few studies that focus on the important organs injuries induced by total hepatic ischemia and reperfusion (THIR), which is a key to save the lives of hepatic surgery patients...
  19. Budić I, Pavlovic D, Cvetkovic T, Djordjević N, Simic D, Milojevic I, et al. The effects of different anesthesia techniques on free radical production after tourniquet-induced ischemia-reperfusion injury at children's age. Vojnosanit Pregl. 2010;67:659-64 pubmed
    b>Reperfusion of previously ischemic tissue leads to injuries mediated by reactive oxygen species...
  20. Cao L, Arany P, Kim J, RIVERA FELICIANO J, Wang Y, He Z, et al. Modulating Notch signaling to enhance neovascularization and reperfusion in diabetic mice. Biomaterials. 2010;31:9048-56 pubmed publisher
    ..In summary, modulating Notch signaling enhances neovascularization and perfusion recovery in diabetic mice suffering from ischemia, suggesting this approach could have utility for human diabetics. ..
  21. Siniscalchi A, Dante A, Spedicato S, Riganello L, Zanoni A, Cimatti M, et al. Hyperdynamic circulation in acute liver failure: reperfusion syndrome and outcome following liver transplantation. Transplant Proc. 2010;42:1197-9 pubmed publisher
    ..The most critical phase during OLT is considered to be graft reperfusion, where in large changes in patient homeostasis occur...
  22. Gourdin M, Dubois P, Mullier F, Chatelain B, Dogne J, Marchandise B, et al. The effect of clonidine, an alpha-2 adrenergic receptor agonist, on inflammatory response and postischemic endothelium function during early reperfusion in healthy volunteers. J Cardiovasc Pharmacol. 2012;60:553-60 pubmed publisher
    Ischemia-reperfusion disturbs endothelial physiology and generates a proinflammatory state. Animal studies showed that clonidine administered prior hypoxia improves posthypoxic endothelial function...
  23. Anik I, Kokturk S, Genc H, Cabuk B, Koc K, Yavuz S, et al. Immunohistochemical analysis of TIMP-2 and collagen types I and IV in experimental spinal cord ischemia-reperfusion injury in rats. J Spinal Cord Med. 2011;34:257-64 pubmed publisher
    ..examine the immunohistochemical analysis of TIMP-2 and collagen types I-IV in experimental spinal cord ischemia-reperfusion in rats...