molecular imaging


Summary: The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; FLUORESCENCE IMAGING; and MICROSCOPY.

Top Publications

  1. Wince W, Kim R. Molecular imaging: T2-weighted CMR of the area at risk--a risky business?. Nat Rev Cardiol. 2010;7:547-9 pubmed publisher
  2. Deutscher S. Phage display in molecular imaging and diagnosis of cancer. Chem Rev. 2010;110:3196-211 pubmed publisher
  3. Ma X, Zhao Y. Biomedical Applications of Supramolecular Systems Based on Host-Guest Interactions. Chem Rev. 2015;115:7794-839 pubmed publisher
  4. Bethge P, Carta S, Lorenzo D, Egolf L, Goniotaki D, Madisen L, et al. An R-CaMP1.07 reporter mouse for cell-type-specific expression of a sensitive red fluorescent calcium indicator. PLoS ONE. 2017;12:e0179460 pubmed publisher
  5. Auberson Y. Medicinal Chemists Don't Just Make Drugs - The Art of Developing Low Molecular Weight Imaging Agents in Switzerland. Chimia (Aarau). 2016;70:868-873 pubmed publisher
    Radiolabeled molecular imaging agents are useful to study drug distribution, target engagement and disease progression in human patients...
  6. Smith A, Mancini M, Nie S. Bioimaging: second window for in vivo imaging. Nat Nanotechnol. 2009;4:710-1 pubmed publisher
  7. Baker M. Genomics: Genomes in three dimensions. Nature. 2011;470:289-94 pubmed publisher
  8. Panizzi P, Stone J, Nahrendorf M. Endocarditis and molecular imaging. J Nucl Cardiol. 2014;21:486-95 pubmed publisher
  9. Haas H, Petrik M, Decristoforo C. An iron-mimicking, Trojan horse-entering fungi--has the time come for molecular imaging of fungal infections?. PLoS Pathog. 2015;11:e1004568 pubmed publisher

More Information

Publications109 found, 100 shown here

  1. Wei L, Chen Z, Shi L, Long R, Anzalone A, Zhang L, et al. Super-multiplex vibrational imaging. Nature. 2017;544:465-470 pubmed publisher
  2. Chen Y, Zhang L, Liu J, Zhang P, Chen X, Xie M. Molecular Imaging of Acute Cardiac Transplant Rejection: Animal Experiments and Prospects. Transplantation. 2017;101:1977-1986 pubmed publisher
    ..b>Molecular imaging sheds new light on AR diagnosis because it can provide information about gene expression and the location of ..
  3. Alexander S, Devaraj N. Developing a Fluorescent Toolbox To Shed Light on the Mysteries of RNA. Biochemistry. 2017;56:5185-5193 pubmed publisher
    ..This perspective seeks to highlight the most recent advances and remaining challenges for the wide-ranging toolbox of technologies that illuminate RNA's contribution to cellular complexity...
  4. Mehta S, Zhang J. Illuminating the Cell's Biochemical Activity Architecture. Biochemistry. 2017;56:5210-5213 pubmed publisher
  5. Yang W, Yuste R. In vivo imaging of neural activity. Nat Methods. 2017;14:349-359 pubmed publisher
    ..Here we review advanced microscopy techniques for in vivo functional imaging and offer guidelines for which technologies are best suited for particular applications. ..
  6. Tseng J, Narayanan N, Ho G, Groves K, Delaney J, Bao B, et al. Fluorescence imaging of bombesin and transferrin receptor expression is comparable to 18F-FDG PET in early detection of sorafenib-induced changes in tumor metabolism. PLoS ONE. 2017;12:e0182689 pubmed publisher
    ..These results suggest that metabolic FLI has potential preclinical application as an additional method for detecting drug-induced metabolic changes in tumors. ..
  7. Zhang C, Xiao Y, Ma Y, Li B, Liu Z, Lu C, et al. Algae biomass as a precursor for synthesis of nitrogen-and sulfur-co-doped carbon dots: A better probe in Arabidopsis guard cells and root tissues. J Photochem Photobiol B. 2017;174:315-322 pubmed publisher
    ..This study highlights the potential application of CDs for bioimaging in plant cells and demonstrates the significance of investigating the reuse of algal biomass. ..
  8. Idowu M, Laudadio J, Rizzo K. Diagnostic, Prognostic, and Predictive Molecular Biomarkers and the Utility of Molecular Imaging in Common Gastrointestinal Tumors. Biomed Res Int. 2015;2015:890805 pubmed publisher
  9. Rashidi L, Ganji F, Vasheghani Farahani E. Fluorescein isothiocyanate-dyed mesoporous silica nanoparticles for tracking antioxidant delivery. IET Nanobiotechnol. 2017;11:454-462 pubmed publisher
    ..It was found that FITC-MSNs can be applied at low concentrations as a marker in the cells. In addition, AP-FITC-MSNs showed better biocompatibility with Caco-2 cells than FITC-MSNs, because of their positive surface charges. ..
  10. Majdalawieh A, Kanan M, El Kadri O, Kanan S. Recent advances in gold and silver nanoparticles: synthesis and applications. J Nanosci Nanotechnol. 2014;14:4757-80 pubmed
    ..Future investigations should aim at overcoming such challenges in an attempt to design nanomaterials that will prove to be useful in diagnosing and treating life-threatening diseases while ensuring a high degree of efficacy and safety. ..
  11. Stahl T, Bofinger R, Lam I, Fallon K, Johnson P, Ogunlade O, et al. Tunable Semiconducting Polymer Nanoparticles with INDT-Based Conjugated Polymers for Photoacoustic Molecular Imaging. Bioconjug Chem. 2017;28:1734-1740 pubmed publisher
  12. Wu J, Li B, Sun X, Cao G, Rubin D, Napel S, et al. Heterogeneous Enhancement Patterns of Tumor-adjacent Parenchyma at MR Imaging Are Associated with Dysregulated Signaling Pathways and Poor Survival in Breast Cancer. Radiology. 2017;285:401-413 pubmed publisher
    ..sup>© RSNA, 2017 Online supplemental material is available for this article. ..
  13. Kolodgie F, Yahagi K, Mori H, Romero M, Trout H, Finn A, et al. High-risk carotid plaque: lessons learned from histopathology. Semin Vasc Surg. 2017;30:31-43 pubmed publisher medical imaging modalities to assess carotid atherosclerosis vulnerability particularly involving molecular imaging, which is now positioned at the forefront to provide a more detailed and mechanistic assessment of stroke ..
  14. Xie W, Deng Y, Wang K, Yang X, Luo Q. Reweighted L1 regularization for restraining artifacts in FMT reconstruction images with limited measurements. Opt Lett. 2014;39:4148-51 pubmed publisher
    ..This indicates that FMT based on IRL1 can obtain high-quality images and thus has the potential to observe dynamic changes in fluorescence-targeted molecules. ..
  15. Clark P, Ebiana V, Gosa L, Cloughesy T, Nathanson D. Harnessing Preclinical Molecular Imaging to Inform Advances in Personalized Cancer Medicine. J Nucl Med. 2017;58:689-696 pubmed publisher
    ..Here, we review the underlying biochemical and biologic basis for a variety of PET tracers and how they may be used to better optimize cancer therapy. ..
  16. Biran A, Zada L, Abou Karam P, Vadai E, Roitman L, Ovadya Y, et al. Quantitative identification of senescent cells in aging and disease. Aging Cell. 2017;16:661-671 pubmed publisher
  17. Zanacchi F, Manzo C, Alvarez A, Derr N, Garcia Parajo M, Lakadamyali M. A DNA origami platform for quantifying protein copy number in super-resolution. Nat Methods. 2017;14:789-792 pubmed publisher
  18. Hennen J, Hur K, Saunders C, Luxton G, MUELLER J. Quantitative Brightness Analysis of Protein Oligomerization in the Nuclear Envelope. Biophys J. 2017;113:138-147 pubmed publisher
  19. Suzuki Y, Tsutsumi K, Miyamoto T, Yamamura H, Imaizumi Y. Heterodimerization of two pore domain K+ channel TASK1 and TALK2 in living heterologous expression systems. PLoS ONE. 2017;12:e0186252 pubmed publisher
    ..Surprisingly, single molecular imaging analyses in this study using a total internal reflection microscope suggested the heterodimerization of ..
  20. Maurer A, Camilleri M, Donohoe K, Knight L, Madsen J, Mariani G, et al. The SNMMI and EANM practice guideline for small-bowel and colon transit 1.0. J Nucl Med. 2013;54:2004-13 pubmed publisher
  21. Strafella A, Bohnen N, Perlmutter J, Eidelberg D, Pavese N, van Eimeren T, et al. Molecular imaging to track Parkinson's disease and atypical parkinsonisms: New imaging frontiers. Mov Disord. 2017;32:181-192 pubmed publisher
    b>Molecular imaging has proven to be a powerful tool for investigation of parkinsonian disorders. One current challenge is to identify biomarkers of early changes that may predict the clinical trajectory of parkinsonian disorders...
  22. Diaconu I, Ballard B, Zhang M, Chen Y, West J, Dotti G, et al. Inducible Caspase-9 Selectively Modulates the Toxicities of CD19-Specific Chimeric Antigen Receptor-Modified T Cells. Mol Ther. 2017;25:580-592 pubmed publisher
    ..CAR-Ts in a dose-dependent manner, allowing either a selective containment of CD19.CAR-T expansion in case of CRS or complete deletion on demand granting normal B cell reconstitution. ..
  23. Brunstein M, Roy L, Oheim M. Near-Membrane Refractometry Using Supercritical Angle Fluorescence. Biophys J. 2017;112:1940-1948 pubmed publisher
    ..Our technique has important applications for imaging axial vesicle dynamics and the mitochondrial energy state or detecting metabolically more active cancer cells. ..
  24. McRae R, Bagchi P, Sumalekshmy S, Fahrni C. In situ imaging of metals in cells and tissues. Chem Rev. 2009;109:4780-827 pubmed publisher
  25. Mastropietro A, De Bernardi E, Breschi G, Zucca I, Cametti M, Soffientini C, et al. Optimization of rapid acquisition with relaxation enhancement (RARE) pulse sequence parameters for ¹?F-MRI studies. J Magn Reson Imaging. 2014;40:162-70 pubmed
    ..Optimal settings according to measured relaxation times can significantly improve the sensitivity threshold in ¹?F MRI studies. They were provided in a wide range of (T?, T?) values and experimentally validated showing good agreement. ..
  26. Camacho X, Machado C, Garcia M, Gambini J, Banchero A, Fernandez M, et al. Technetium-99m- or Cy7-Labeled Rituximab as an Imaging Agent for Non-Hodgkin Lymphoma. Oncology. 2017;92:229-242 pubmed publisher
    ..Our results support the potential use of rituximab labeled either with 99mTc or Cy7 as a molecular imaging tool for staging, restaging, and guiding surgical excision of tumors, which merits further evaluation.
  27. Feng L, Jensen P, Thomsen G, Dyssegaard A, Svarer C, Knudsen L, et al. The Variability of Translocator Protein Signal in Brain and Blood of Genotyped Healthy Humans Using In Vivo 123I-CLINDE SPECT Imaging: A Test-Retest Study. J Nucl Med. 2017;58:989-995 pubmed publisher
    ..The population-adjusted method has the potential to reduce the complexity of blood analyses of TSPO tracers. ..
  28. Batmanghelich N, Dalca A, Sabuncu M, Polina G. Joint modeling of imaging and genetics. Inf Process Med Imaging. 2013;23:766-77 pubmed
    ..We evaluate the algorithm on synthetic data and show that it outperforms traditional models. We also illustrate the application of the method on ADNI data. ..
  29. Koldenkova V, Matsuda T, Nagai T. MagIC, a genetically encoded fluorescent indicator for monitoring cellular Mg2+ using a non-Förster resonance energy transfer ratiometric imaging approach. J Biomed Opt. 2015;20:101203 pubmed publisher
    ..Our results confirm the functionality of MagIC as a useful tool for the long-awaited possibility of prolonged and organelle-specific monitoring of cellular Mg(2+). ..
  30. Lamb C, Joachim J, Tooze S. Quantifying Autophagic Structures in Mammalian Cells Using Confocal Microscopy. Methods Enzymol. 2017;587:21-42 pubmed publisher
    ..We also discuss methods to monitor the trafficking of ATG9 in mammalian cells under starvation conditions. ..
  31. Xu Y, Zou P, Cohen A. Voltage imaging with genetically encoded indicators. Curr Opin Chem Biol. 2017;39:1-10 pubmed publisher
    ..We also highlight the protein engineering strategies employed to improve the dynamic range and kinetics of GEVIs and opportunities for future advances. ..
  32. Frenz B, Walls A, Egelman E, Veesler D, DiMaio F. RosettaES: a sampling strategy enabling automated interpretation of difficult cryo-EM maps. Nat Methods. 2017;14:797-800 pubmed publisher
    ..On a benchmark set of nine proteins, RosettaES was able to identify near-native conformations in 85% of segments. RosettaES was also used to determine models for three challenging macromolecular structures. ..
  33. Jain A, Kameswaran M, Pandey U, Prabhash K, Sarma H, Dash A. 68Ga labeled Erlotinib: A novel PET probe for imaging EGFR over-expressing tumors. Bioorg Med Chem Lett. 2017;27:4552-4557 pubmed publisher
    b>Molecular imaging using radiolabeled Tyrosine Kinase Inhibitors (TKI) is a promising strategy for detection and staging of EGFR-positive cancers...
  34. Carrio I. EJNMMI: the European way of communicating science. Eur J Nucl Med Mol Imaging. 2013;40:1-3 pubmed publisher
  35. Agarwal H, Reisser M, Wortmann C, Gebhardt J. Direct Observation of Cell-Cycle-Dependent Interactions between CTCF and Chromatin. Biophys J. 2017;112:2051-2055 pubmed publisher
    ..During S-phase, dynamic and stable interactions decreased considerably compared to G1-phase, but were resumed in G2-phase, indicating that specific interactions need to be dissolved for replication to proceed. ..
  36. Nöbauer T, Skocek O, Pernía Andrade A, Weilguny L, Traub F, Molodtsov M, et al. Video rate volumetric Ca2+ imaging across cortex using seeded iterative demixing (SID) microscopy. Nat Methods. 2017;14:811-818 pubmed publisher
    ..We expect that the simplicity and scalability of LFM, coupled with the performance of SID, will open up a range of applications including closed-loop experiments. ..
  37. Glunde K, Artemov D, Penet M, Jacobs M, Bhujwalla Z. Magnetic resonance spectroscopy in metabolic and molecular imaging and diagnosis of cancer. Chem Rev. 2010;110:3043-59 pubmed publisher
  38. Dutta Gupta S, Karmakar A. Machine vision based evaluation of impact of light emitting diodes (LEDs) on shoot regeneration and the effect of spectral quality on phenolic content and antioxidant capacity in Swertia chirata. J Photochem Photobiol B. 2017;174:162-172 pubmed publisher
    ..The findings demonstrate the ability of LEDs in inducing shoot regeneration as well as accumulation of phenolic antioxidants and suggest that the proportion of blue and red LEDs is an important factor in achieving the optimum response. ..
  39. Adam L, Murali N, Chapiro J, Geschwind J. Science to Practice: Molecular-targeted Drug Delivery in Combination with Radiofrequency Ablation of Liver Cancer: A Magic Bullet?. Radiology. 2017;285:333-335 pubmed publisher
  40. Kudo T, Jeknic S, Macklin D, Akhter S, Hughey J, Regot S, et al. Live-cell measurements of kinase activity in single cells using translocation reporters. Nat Protoc. 2018;13:155-169 pubmed publisher
    ..We provide detailed guidance for a computational analysis and parameterization pipeline. The entire procedure, from virus production to data analysis, can be completed in ∼10 d. ..
  41. Bünzli J. Lanthanide luminescence for biomedical analyses and imaging. Chem Rev. 2010;110:2729-55 pubmed publisher
  42. Signore A, Mather S, Piaggio G, Malviya G, Dierckx R. Molecular imaging of inflammation/infection: nuclear medicine and optical imaging agents and methods. Chem Rev. 2010;110:3112-45 pubmed publisher
  43. Duong T, Kim J. Fluoro- and chromogenic chemodosimeters for heavy metal ion detection in solution and biospecimens. Chem Rev. 2010;110:6280-301 pubmed publisher
  44. Gangadaran P, Hong C, Ahn B. Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging. Biomed Res Int. 2017;2017:9158319 pubmed publisher
    ..In this review, we summarize several molecular imaging methods that deal with EVs derived from different cells, which have allowed investigations of EV ..
  45. Lajoinie G, van Rooij T, Skachkov I, Blazejewski E, Veldhuis G, de Jong N, et al. Laser-Activated Polymeric Microcapsules for Ultrasound Imaging and Therapy: In Vitro Feasibility. Biophys J. 2017;112:1894-1907 pubmed publisher
    ..The controlled and localized cell destruction achieved by activation of both capsule formulations may provide an innovative approach for specifically inducing cell death in vivo, e.g., for cancer therapy. ..
  46. Ovryn B, Li J, Hong S, Wu P. Visualizing glycans on single cells and tissues-Visualizing glycans on single cells and tissues. Curr Opin Chem Biol. 2017;39:39-45 pubmed publisher
    ..The presented applications demonstrate that several of the leading imaging methods, which have revolutionized quantitative cell biology, can be adapted to imaging glycans on single cells and tissues. ..
  47. Noda N, Awais R, Sutton R, Awais M, Ozawa T. Dynamic monitoring of p53 translocation to mitochondria for the analysis of specific inhibitors using luciferase-fragment complementation. Biotechnol Bioeng. 2017;114:2818-2827 pubmed publisher
    ..This p53 mitochondrial translocation assay is a new tool for high-throughput screening to identify novel p53 inhibitors, which could be developed as drugs to treat diseases in which necrotic cell death is a major contributor. ..
  48. Mohajerani P, Hipp A, Willner M, Marschner M, Trajkovic Arsic M, Ma X, et al. FMT-PCCT: hybrid fluorescence molecular tomography-x-ray phase-contrast CT imaging of mouse models. IEEE Trans Med Imaging. 2014;33:1434-46 pubmed publisher
    ..The results point to the most accurate FMT performance to date. ..
  49. Carrio I, Kinuya S. New section in EJNMMI and Annals of Nuclear Medicine. Ann Nucl Med. 2016;30:593 pubmed
  50. Liu B, Ã…berg C, van Eerden F, Marrink S, Poolman B, Boersma A. Design and Properties of Genetically Encoded Probes for Sensing Macromolecular Crowding. Biophys J. 2017;112:1929-1939 pubmed publisher
    ..The collection of new probes provides more detailed readouts on the macromolecular crowding than a single sensor. ..
  51. Gould A, Camarero J. Cyclotides: Overview and Biotechnological Applications. Chembiochem. 2017;18:1350-1363 pubmed publisher
    ..This article provides an overview on cyclotides and their applications as molecular imaging agents and peptide-based therapeutics.
  52. Mellis I, Gupte R, Raj A, Rouhanifard S. Visualizing adenosine-to-inosine RNA editing in single mammalian cells. Nat Methods. 2017;14:801-804 pubmed publisher
    ..Further, NUP43 exhibits constant editing levels between single cells, while GRIA2 editing levels vary...
  53. Niu J, Li Z. The roles of integrin αvβ6 in cancer. Cancer Lett. 2017;403:128-137 pubmed publisher
    ..Furthermore, the common links as well as discrepancies between independent studies are also discussed. ..
  54. Holland J. The Role of Molecular Imaging in Personalised Healthcare. Chimia (Aarau). 2016;70:787-795 pubmed publisher
    Functional molecular imaging provides a unique perspective on a disease...
  55. Sinkeldam R, Greco N, Tor Y. Fluorescent analogs of biomolecular building blocks: design, properties, and applications. Chem Rev. 2010;110:2579-619 pubmed publisher
  56. Ntziachristos V, Razansky D. Molecular imaging by means of multispectral optoacoustic tomography (MSOT). Chem Rev. 2010;110:2783-94 pubmed publisher
  57. Buxton D. Molecular imaging of aortic aneurysms. Circ Cardiovasc Imaging. 2012;5:392-9 pubmed publisher
  58. McGorty R, Schnitzbauer J, Zhang W, Huang B. Correction of depth-dependent aberrations in 3D single-molecule localization and super-resolution microscopy. Opt Lett. 2014;39:275-8 pubmed publisher
    ..Our super-resolution images of a mammalian cell nucleus acquired between 0 and 2.5 ?m past the coverslip show that this method produces accurate z localizations even in the deepest focal plane. ..
  59. Put S, Westhovens R, Lahoutte T, Matthys P. Molecular imaging of rheumatoid arthritis: emerging markers, tools, and techniques. Arthritis Res Ther. 2014;16:208 pubmed publisher
    ..b>Molecular imaging might facilitate more effective diagnosis and monitoring in addition to providing new information on the ..
  60. Zhang H, Tian M, Carrio I, Civelek A, Fujibayashi Y. Molecular image-guided theranostic and personalized medicine 2013. Biomed Res Int. 2014;2014:682527 pubmed publisher
  61. Livi L, Isidori A, Sherris D, Gravina G. Advances in prostate cancer research and treatment. Biomed Res Int. 2014;2014:708383 pubmed publisher
  62. Zhang H, Tian M, Carrio I, Civelek A, Fujibayashi Y. Molecular image-guided theranostic and personalized medicine 2014. Biomed Res Int. 2015;2015:258612 pubmed publisher
  63. Rischpler C, Nekolla S, Kossmann H, Dirschinger R, Schottelius M, Hyafil F, et al. Upregulated myocardial CXCR4-expression after myocardial infarction assessed by simultaneous GA-68 pentixafor PET/MRI. J Nucl Cardiol. 2016;23:131-3 pubmed publisher
  64. Figliozzi R, Chen F, Chi A, Hsia S. Using the inverse Poisson distribution to calculate multiplicity of infection and viral replication by a high-throughput fluorescent imaging system. Virol Sin. 2016;31:180-3 pubmed publisher
  65. Rahamim G, Amir D, Haas E. Simultaneous Determination of Two Subdomain Folding Rates Using the "Transfer-Quench" Method. Biophys J. 2017;112:1786-1796 pubmed publisher
    ..We found that the closure of the loop (segment 14-33) occurs with the same rate constant as the nucleation of helix HII (segment 33-29), in line with the nucleation-condensation model. ..
  66. Zhao Y, Bucur O, Irshad H, Chen F, Weins A, Stancu A, et al. Nanoscale imaging of clinical specimens using pathology-optimized expansion microscopy. Nat Biotechnol. 2017;35:757-764 pubmed publisher
    ..ExPath may enable the routine use of nanoscale imaging in pathology and clinical research. ..
  67. Thompson A, Bewersdorf J, Toomre D, Schepartz A. HIDE Probes: A New Toolkit for Visualizing Organelle Dynamics, Longer and at Super-Resolution. Biochemistry. 2017;56:5194-5201 pubmed publisher
  68. Hell S, Rittweger E. Microscopy: Light from the dark. Nature. 2009;461:1069-70 pubmed publisher
  69. Lee S, Park H, Yoo K. Synergistic cancer therapeutic effects of locally delivered drug and heat using multifunctional nanoparticles. Adv Mater. 2010;22:4049-53 pubmed publisher
  70. Liu S, Kromann E, Krueger W, Bewersdorf J, Lidke K. Three dimensional single molecule localization using a phase retrieved pupil function. Opt Express. 2013;21:29462-87 pubmed publisher
    ..The superior localization accuracy of the pupil function generated PSF is demonstrated with dual focal plane 3D superresolution imaging of biological structures. ..
  71. Dong H, Du S, Zheng X, Lyu G, Sun L, Li L, et al. Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy. Chem Rev. 2015;115:10725-815 pubmed publisher
  72. Gonzalez Burgos M, Latorre Sanchez A, Pomposo J. Advances in single chain technology. Chem Soc Rev. 2015;44:6122-42 pubmed
  73. Wagner M, Kim T, Savall J, Schnitzer M, Luo L. Cerebellar granule cells encode the expectation of reward. Nature. 2017;544:96-100 pubmed publisher
  74. Wang T, Yuan C, Dai B, Liu Y, Li M, Feng Z, et al. Click-Chemistry-Mediated Rapid Microbubble Capture for Acute Thrombus Ultrasound Molecular Imaging. Chembiochem. 2017;18:1364-1368 pubmed publisher
    Bioorthogonal coupling chemistry has been studied as a potentially advantageous approach for molecular imaging because it offers rapid, efficient, and strong binding, which might also benefit stability, production, and chemical ..
  75. Hagimori M, Fuchigami Y, Kawakami S. Peptide-Based Cancer-Targeted DDS and Molecular Imaging. Chem Pharm Bull (Tokyo). 2017;65:618-624 pubmed publisher
    ..receptors and applied to nanoparticles with anticancer drugs, genes, small interfering RNAs (siRNAs), and molecular imaging agents...
  76. Bohl C, Pomorski A, Seemann S, Knospe A, Zheng C, Krężel A, et al. Fluorescent probes for selective protein labeling in lysosomes: a case of α-galactosidase A. FASEB J. 2017;31:5258-5267 pubmed publisher
    ..Bohl, C., Pomorski, A., Seemann, S., Knospe, A.-M., Zheng, C., Krężel, A., Rolfs, A., Lukas, J. Fluorescent probes for selective protein labeling in lysosomes: a case of α-galactosidase A. ..
  77. Kim C, Favazza C, Wang L. In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths. Chem Rev. 2010;110:2756-82 pubmed publisher
  78. Zhao X, Zhao H, Chen Z, Lan M. Ultrasmall superparamagnetic iron oxide nanoparticles for magnetic resonance imaging contrast agent. J Nanosci Nanotechnol. 2014;14:210-20 pubmed
    ..This review will mainly discuss the synthesis of USPIOs and their applications as MRI contrast agent for disease detection. ..
  79. Yen T, Visvikis D, Pan T, Fang Y. Biomedical imaging: role and opportunities of medical imaging in the "omics" era. Biomed Res Int. 2014;2014:930213 pubmed publisher
  80. Beer A, Dijkgraaf I. Editorial European Journal of Nuclear Medicine and Molecular Imaging. Eur J Nucl Med Mol Imaging. 2017;44:284-285 pubmed publisher
  81. Romano S, Pérez Schuster V, Jouary A, Boulanger Weill J, Candeo A, Pietri T, et al. An integrated calcium imaging processing toolbox for the analysis of neuronal population dynamics. PLoS Comput Biol. 2017;13:e1005526 pubmed publisher
    ..The toolbox open-source code, a step-by-step tutorial and a case study dataset are available at ..
  82. Zhu L, Guo Y, Wang L, Fan X, Xiong X, Fang K, et al. Construction of ultrasonic nanobubbles carrying CAIX polypeptides to target carcinoma cells derived from various organs. J Nanobiotechnology. 2017;15:63 pubmed publisher
    Ultrasound molecular imaging is a novel diagnostic approach for tumors, whose key link is the construction of targeted ultrasound contrast agents...
  83. Ayton S, James S, Bush A. Nanoscale Imaging Reveals Big Role for Iron in Alzheimer's Disease. Cell Chem Biol. 2017;24:1192-1194 pubmed publisher
    ..The characterization of abnormal iron chemistry in the disease model highlights the potential for iron to combine with the ?-amyloid peptide and accelerate the disease process...
  84. Beatty K, Szychowski J, Fisk J, Tirrell D. A BODIPY-cyclooctyne for protein imaging in live cells. Chembiochem. 2011;12:2137-9 pubmed publisher
  85. Dong Z, Andrews T, Xie C, Yokoo T. Advances in MRI Techniques and Applications. Biomed Res Int. 2015;2015:139043 pubmed publisher
  86. Russell J, Tian J, Kinuya S, Shen B, Li X. Molecular Imaging for Personalized Medicine. Biomed Res Int. 2016;2016:5170159 pubmed publisher
  87. Zappavigna S, Lombardi A, Misso G, Grimaldi A, Caraglia M. Measurement of Autophagy by Flow Cytometry. Methods Mol Biol. 2017;1553:209-216 pubmed publisher
    ..Here, we detail the in vitro methods currently available to detect autophagic cell death by flow cytometry analysis. ..
  88. Hellström Lindahl E, Aberg O, Ericsson C, O Mahony G, Johnström P, Skrtic S, et al. Toward molecular imaging of the free fatty acid receptor 1. Acta Diabetol. 2017;54:663-668 pubmed publisher
    b>Molecular imaging of the free fatty acid receptor 1 (FFAR1) would be a valuable tool for drug development by enabling in vivo target engagement studies in human...
  89. Fei B, Schuster D. PET Molecular Imaging-Directed Biopsy: A Review. AJR Am J Roentgenol. 2017;209:255-269 pubmed publisher
    The purpose of this review is to summarize the applications of PET molecular imaging-directed biopsy of a variety of organs in the management of various diseases with a focus on cancers...
  90. Fu D. Quantitative chemical imaging with stimulated Raman scattering microscopy. Curr Opin Chem Biol. 2017;39:24-31 pubmed publisher
    ..I will focus on developments in SRS imaging that enable detection of non-fluorescent molecules and drive new biological applications. ..
  91. Chen I, Wu J. Cardiovascular molecular imaging: focus on clinical translation. Circulation. 2011;123:425-43 pubmed publisher
  92. Yang Y, Zhao Q, Feng W, Li F. Luminescent chemodosimeters for bioimaging. Chem Rev. 2013;113:192-270 pubmed publisher