Summary: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Top Publications

  1. Demidova I, Barinov A, Savelov N, Gagarin I, Grinevitch V, Stroiakovaski D, et al. Immunohistochemistry, fluorescence in situ hybridization, and reverse transcription-polymerase chain reaction for the detection of anaplastic lymphoma kinase gene rearrangements in patients with non-small cell lung cancer: potential advantages and me. Arch Pathol Lab Med. 2014;138:794-802 pubmed publisher
    ..To investigate the concordance, sensitivity, and specificity of immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and reverse transcription-polymerase chain reaction (RT-..
  2. McKelvie P, Chan F, Yu Y, Waring P, Gresshoff I, Farrell S, et al. The prognostic significance of the BRAF V600E mutation in papillary thyroid carcinoma detected by mutation-specific immunohistochemistry. Pathology. 2013;45:637-44 pubmed publisher
    ..BRAF mutation has been shown in a large meta-analysis to be an independent prognostic marker for papillary thyroid carcinoma (PTC) with poorer survival and higher recurrence rates...
  3. Wolff A, Hammond M, Hicks D, Dowsett M, McShane L, Allison K, et al. Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update. Arch Pathol Lab Med. 2014;138:241-56 pubmed publisher
  4. Zhang Y, Cheng S, Zhang M, Zhen L, Pang D, Zhang Q, et al. High-infiltration of tumor-associated macrophages predicts unfavorable clinical outcome for node-negative breast cancer. PLoS ONE. 2013;8:e76147 pubmed publisher
    ..High-infiltration of TAMs is a significant unfavorable prognostic factor for patients with invasive breast cancer and, as such, is a potentially useful prognostic marker for breast cancer. ..
  5. Lee A, Key H, Bell J, Kumah P, Hodi Z, Ellis I. The effect of delay in fixation on HER2 expression in invasive carcinoma of the breast assessed with immunohistochemistry and in situ hybridisation. J Clin Pathol. 2014;67:573-5 pubmed publisher
    ..All carcinomas were scored as 3+ with immunohistochemistry in properly fixed tissue...
  6. Varga Z, Noske A, Ramach C, Padberg B, Moch H. Assessment of HER2 status in breast cancer: overall positivity rate and accuracy by fluorescence in situ hybridization and immunohistochemistry in a single institution over 12 years: a quality control study. BMC Cancer. 2013;13:615 pubmed publisher
    The gold standard of HER2 status assessment in breast cancer is still debated. Immunohistochemistry (IHC) and in-situ technology as fluorescent-labeled methodology (FISH) can be influenced by pre-analytical factors, assay-conditions and ..
  7. Elesawy B, Abd El Hafez A, Shawky A, Arafa M. Immunohistochemistry-based subtyping of breast carcinoma in Egyptian women: a clinicopathologic study on 125 patients. Ann Diagn Pathol. 2014;18:21-6 pubmed publisher
    ..identified several molecular subtypes, and similar subtyping has now been found to be feasible using immunohistochemistry. This study estimated the distribution of intrinsic breast cancer subtypes using estrogen receptor, ..
  8. Gailey M, Bellizzi A. Immunohistochemistry for the novel markers glypican 3, PAX8, and p40 (?Np63) in squamous cell and urothelial carcinoma. Am J Clin Pathol. 2013;140:872-80 pubmed publisher
    ..b>Immunohistochemistry for GPC3, PAX8, and p40 was performed on whole sections of 107 SCCs from 11 anatomic sites and 49 UCs; ..
  9. Bentz S, Cee A, Endlicher E, Wojtal K, Naami A, Pesch T, et al. Hypoxia induces the expression of transketolase-like 1 in human colorectal cancer. Digestion. 2013;88:182-92 pubmed publisher
    ..expression in CRC cell lines and human CRC biopsies by quantitative real-time PCR, Western blotting and immunohistochemistry. Regulation of TKTL1 under oxygen depletion was analyzed by cultivating cells either in a three-dimensional ..

More Information


  1. Vannucchi M, Traini C, Manetti M, Ibba Manneschi L, Faussone Pellegrini M. Telocytes express PDGFRα in the human gastrointestinal tract. J Cell Mol Med. 2013;17:1099-108 pubmed publisher
    ..In conclusion, in the human GI tract the TC are PDGFRα-positive and, therefore, might correspond to the FLC. We also hypothesize that in human gut, there are different TC subpopulations probably playing region-specific roles. ..
  2. Culpin R, Sieniawski M, Angus B, Menon G, Proctor S, Milne P, et al. Prognostic significance of immunohistochemistry-based markers and algorithms in immunochemotherapy-treated diffuse large B cell lymphoma patients. Histopathology. 2013;63:788-801 pubmed publisher
    ..60, P < 0.001 and PFS; HR: 2.91, P < 0.001). Results highlight the controversy surrounding immunohistochemistry-based algorithms in the R-CHOP era...
  3. Gonzalez M, Moore H, Li X, Toy K, Huang W, Sabel M, et al. EZH2 expands breast stem cells through activation of NOTCH1 signaling. Proc Natl Acad Sci U S A. 2014;111:3098-103 pubmed publisher
    ..These data reveal a functional and mechanistic link between EZH2 levels, NOTCH1 signaling activation, and TICs, and provide previously unidentified evidence that EZH2 enhances breast cancer initiation. ..
  4. Chen Q, Xia C, Deng Y, Wang M, Luo P, Wu C, et al. Immunohistochemistry as a quick screening method for clinical detection of BRAF(V600E) mutation in melanoma patients. Tumour Biol. 2014;35:5727-33 pubmed publisher
    ..Using routine manual immunohistochemistry (IHC), we tested tumor tissues from 38 melanoma patients...
  5. Slatter T, Park L, Anderson K, Lailai Tasmania V, Herbison P, Clow W, et al. Smoking during pregnancy causes double-strand DNA break damage to the placenta. Hum Pathol. 2014;45:17-26 pubmed publisher
    ..In summary, smoking during pregnancy was associated with marked double-strand DNA break damage to the syncytiotrophoblast. We suggest that smoking cessation is important to prevent additional DNA damage and to facilitate DNA repair. ..
  6. Roy S, Esmaeilniakooshkghazi A, Patnaik S, Wang Y, George S, Ahrorov A, et al. Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation. Gastroenterology. 2018;154:1405-1420.e2 pubmed publisher
    ..from mice; IECs and enteroids were cultured and analyzed by histology, immunoblots, phalloidin staining, immunohistochemistry, electron microscopy, and flow cytometry...
  7. Song X, Zhu S, Xie Y, Liu J, Sun L, Zeng D, et al. JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice. Gastroenterology. 2018;154:1480-1493 pubmed publisher
    ..Pancreata were collected from mice and analyzed for tumor growth and by histology and immunohistochemistry. We compared gene and protein expression levels between human pancreatic cancer tissues and patient ..
  8. Hu X, Deng J, Yu T, Chen S, Ge Y, Zhou Z, et al. ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides. Gastroenterology. 2019;156:1098-1111 pubmed publisher
    ..ileal and colon tissues were analyzed by quantitative real-time polymerase chain reaction, immunoblots, and immunohistochemistry. Serum and intestinal epithelial cell (IEC) amino acids were measured by high-performance liquid ..
  9. Rueda E, Johnson J, Giddabasappa A, Swaroop A, Brooks M, Sigel I, et al. The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and ~P transferring kinases. Mol Vis. 2016;22:847-85 pubmed
    ..Fixed-frozen retinas from adult C57BL/6N mice were used for immunohistochemistry, laser scanning confocal microscopy, and enzymatic histochemistry...
  10. da Rosa M, João Ribeiro C, Seminotti B, Teixeira Ribeiro R, Amaral A, Coelho D, et al. In vivo intracerebral administration of L-2-hydroxyglutaric acid provokes oxidative stress and histopathological alterations in striatum and cerebellum of adolescent rats. Free Radic Biol Med. 2015;83:201-13 pubmed publisher
    ..b>Immunohistochemistry revealed that L-2-HG treatment provoked an increase of GFAP and a decrease of NeuN immunostaining, ..
  11. Tao G, Pan L, Jing R, Lin F, Dai H, Ge W. [Study on Rac1/MAPK/ERK pathway mediated mechanism and role in rats with ventilator induced lung injury]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:249-254 pubmed publisher
    ..positive expressions of phosphorylation of extracellular signal-regulated kinase (p-ERK) were determined by immunohistochemistry, and those of Rac1 and F-actin were determined by immunofluorescence...
  12. Elmallah M, Elkhadragy M, Al Olayan E, Abdel Moneim A. Protective Effect of Fragaria ananassa Crude Extract on Cadmium-Induced Lipid Peroxidation, Antioxidant Enzymes Suppression, and Apoptosis in Rat Testes. Int J Mol Sci. 2017;18: pubmed publisher
    ..b>Immunohistochemistry of the testicular tissue possessed positive immunostaining for the increased level of TNF-α, but decreased ..
  13. Permana H, Darmawan G, Ritonga E, Kusumawati M, Miftahurachman M, Soetedjo N. An Interesting Case of Hepatic Adrenocortical Carcinoma. Acta Med Indones. 2018;50:257-259 pubmed
    ..Further liver biopsy showed morphology and immunohistochemistry (positive for CD 56, HEP 1, and NSE) consistent with adrenocortical carcinoma...
  14. Liu T, Yang H, Fan W, Tu J, Li T, Wang J, et al. Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. Gastroenterology. 2018;155:557-571.e14 pubmed publisher
    ..Tissues were analyzed by immunohistochemistry. MAT1A, MAT2A, c-MYC, and MAFG were overexpressed or knocked down with small interfering RNAs in MzChA-1, ..
  15. Yilmaz H, Tekelioglu B, Gurel A, Bamac O, Ozturk G, Cizmecigil U, et al. Frequency, clinicopathological features and phylogenetic analysis of feline morbillivirus in cats in Istanbul, Turkey. J Feline Med Surg. 2017;19:1206-1214 pubmed publisher
    ..cells in kidney and hepatocytes, lymphoid and plasma cells in liver from dead cats were also positive by immunohistochemistry for the viral N protein...
  16. Krishnaraj J, Kowshik J, Sebastian R, Raghavan S, Nagini S. Exposure to welding fumes activates DNA damage response and redox-sensitive transcription factor signalling in Sprague-Dawley rats. Toxicol Lett. 2017;274:8-19 pubmed publisher
    ..were assessed by flow cytometry, quantitative real-time reverse transcriptase PCR, immunoblotting, immunohistochemistry and immunofluorescence...
  17. Yoshikawa T, Wu J, Otsuka M, Kishikawa T, Suzuki N, Takata A, et al. Repression of MicroRNA Function Mediates Inflammation-associated Colon Tumorigenesis. Gastroenterology. 2017;152:631-643 pubmed publisher
    ..Cells were analyzed by immunoblots, immunohistochemistry, and flow cytometry...
  18. Jing Y, Cai D, Chen Q, Xiong Q, Hu T, Yao Y, et al. Liuwei Dihuang soft capsules attenuates endothelial cell apoptosis to prevent atherosclerosis through GPR30-mediated regulation in ovariectomized ApoE-deficient mice. J Ethnopharmacol. 2017;208:185-198 pubmed publisher
    ..protein coupled estrogen receptor 30 (GPR30) expressions in the aortic arch endothelium were determined by immunohistochemistry and Western blot...
  19. Hua F, Shang S, Yang Y, Zhang H, Xu T, Yu J, et al. TRIB3 Interacts With β-Catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis. Gastroenterology. 2019;156:708-721.e15 pubmed publisher
    ..Intestinal tissues were collected and analyzed by histology, gene expression profiling, immunohistochemistry, and immunofluorescence...
  20. Zhang L, Li Y, Guan C, Tian S, Lv X, Li J, et al. Therapeutic effect of human umbilical cord-derived mesenchymal stem cells on injured rat endometrium during its chronic phase. Stem Cell Res Ther. 2018;9:36 pubmed publisher
    ..cells of endometrium, cell proliferation and angiogenesis, and inflammatory factors were detected using immunohistochemistry, Western blotting, and quantitative reverse-transcription polymerase chain reaction...
  21. Tian Y, Xu J, Li Y, Zhao R, Du S, Lv C, et al. MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice. Gastroenterology. 2019;: pubmed publisher
    ..Intestinal tissues were collected and analyzed by histology and immunohistochemistry. Levels of MIR31 were increased in inflamed mucosa from patients with CD or UC, and from mice with colitis, ..
  22. Yang X, Yuan L, Xiong C, Yin C, Ruan J. Abacopteris penangiana exerts testosterone-induced benign prostatic hyperplasia protective effect through regulating inflammatory responses, reducing oxidative stress and anti-proliferative. J Ethnopharmacol. 2014;157:105-13 pubmed publisher
    ..of nuclear transcription factor-κB (NF-κB) and phosphoinositide3-kinase (PI3K)/Akt were determined by immunohistochemistry. The prostatic expression of Bcl-2 was determined by western blot analysis...
  23. Hayashi Y, Toyomasu Y, Saravanaperumal S, Bardsley M, Smestad J, Lorincz A, et al. Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying. Gastroenterology. 2017;153:521-535.e20 pubmed publisher
    ..isometric contractility measurement, reverse-transcription polymerase chain reaction, immunoblot, immunohistochemistry, enzyme-linked immunosorbent assays, and metabolite assays; cells and tissues were manipulated ..
  24. Mantilla J, Antic T, Tretiakova M. GATA3 as a valuable marker to distinguish clear cell papillary renal cell carcinomas from morphologic mimics. Hum Pathol. 2017;66:152-158 pubmed publisher
    ..In conclusion, GATA3 is specific and sensitive for CCPRCC and can be used for accurate distinction from its main mimickers. Coexpression of GATA3 and CK7 in most CCPRCC provides evidence of their origin from distal nephron. ..
  25. Liu X, Sun L, Chen J, Jin Y, Liu Q, Xia Z, et al. Effects of local cardiac denervation on cardiac innervation and ventricular arrhythmia after chronic myocardial infarction. PLoS ONE. 2017;12:e0181322 pubmed publisher
    ..Our study suggests that this methodology might decrease malignant ventricular arrhythmia in chronic MI, and has a great potential for clinical application. ..
  26. Uzêda E Silva V, Rodriguez T, Ramalho L, Xavier F, de Castro I, Pinheiro A, et al. Does laser phototherapy influence the proliferation of myoepithelial cells in the salivary gland of hypothyroid rats?. J Photochem Photobiol B. 2017;173:681-685 pubmed publisher
    ..001).It is concluded that, despite the LPT protocol used did not influence myoepithelial proliferation on hypothyroid rats it significantly increased the proliferation on euthyroid animals. ..
  27. Charles N, Boyer D. Mixed-Phenotype Acute Leukemia: Diagnostic Criteria and Pitfalls. Arch Pathol Lab Med. 2017;141:1462-1468 pubmed publisher
    ..The purpose of this review is to explain the diagnostic criteria for MPAL, summarize its biological and clinical features, and address common diagnostic pitfalls of these unusual leukemias...
  28. Zhao M, Tang S, Xin J, Liu D. Influence of reactive oxygen species on secretory component in the intestinal epithelium during hyperoxia. Exp Ther Med. 2017;14:4033-4040 pubmed publisher
    ..Flow cytometry, immunohistochemistry staining, western blot analysis and reverse transcription-quantitative polymerase chain reaction were ..
  29. Chandrakumar L, Bagyánszki M, Szalai Z, Mezei D, Bódi N. Diabetes-Related Induction of the Heme Oxygenase System and Enhanced Colocalization of Heme Oxygenase 1 and 2 with Neuronal Nitric Oxide Synthase in Myenteric Neurons of Different Intestinal Segments. Oxid Med Cell Longev. 2017;2017:1890512 pubmed publisher
    ..colon of control and streptozotocin-induced diabetic rats were processed for double-labelling fluorescent immunohistochemistry and ELISA...
  30. Braun C, Kalbitz M, Halbgebauer R, Eisele P, Messerer D, Weckbach S, et al. Early structural changes of the heart after experimental polytrauma and hemorrhagic shock. PLoS ONE. 2017;12:e0187327 pubmed publisher
    ..troponin I in plasma and assessed histological specimen of the mouse heart via standard histomorphology and immunohistochemistry for cellular and subcellular damage and ongoing apoptosis...
  31. Monteserin L, Mesa A, Fernández García M, Gadañón García A, Rodriguez M, Varela M. Bone metastases as initial presentation of hepatocellular carcinoma. World J Hepatol. 2017;9:1158-1165 pubmed publisher
    ..Morphological characteristics and immunohistochemistry from the examined bone were the key data for diagnosis...
  32. Fu L, Lv Y, Zhong Y, He Q, Liu X, Du L. Tyrosine phosphorylation of Kv1.5 is upregulated in intrauterine growth retardation rats with exaggerated pulmonary hypertension. Braz J Med Biol Res. 2017;50:e6237 pubmed publisher
    ..5 expression in PASMCs. This phenomenon may be mediated by increased tyrosine phosphorylation of Kv1.5 in PASMCs and it provides new insight into the prevention and treatment of IUGR-related CH-PAH. ..
  33. Cortegoso A, Laureano N, Silva A, Danilevicz C, Magnusson A, Visioli F, et al. Cell proliferation markers at the invasive tumor front of oral squamous cell carcinoma: comparative analysis in relation to clinicopathological parameters of patients. J Appl Oral Sci. 2017;25:318-323 pubmed publisher
    ..Our results suggest that proliferation markers as AgNOR and Ki-67 are not prognostic markers at the tumor invasive front of carcinoma of oral squamous cell. ..
  34. Senol S, Ceyran A, Kosemetin D, Gobanoglu B, Aydin D, Duran E, et al. Immunohistochemical Profile of Tumor Pathways and Prognostic Significance in Colon Adenocarcinomas. J Environ Pathol Toxicol Oncol. 2017;36:29-41 pubmed publisher
    ..In survival analyses, the expression of CAIX and AMACR were significantly associated with overall survival in both the univariate and multivariate analyses (log-rank test; p < 0.01 and p < 0.05, respectively). ..
  35. Zhou A, Yan L, Lai F, Chen X, Goto M, Lee K, et al. Design, synthesis and biological evaluation of novel indolin-2-ones as potent anticancer compounds. Bioorg Med Chem Lett. 2017;27:3326-3331 pubmed publisher
    ..Furthermore, immunocytochemical examination of 1c suggested a destabilization of microtubules, which was significantly different from the effect of IM, an indirubin derivative. ..
  36. Feygenzon V, Loewenstein S, Lubezky N, Pasmanic Chor M, Sher O, Klausner J, et al. Unique cellular interactions between pancreatic cancer cells and the omentum. PLoS ONE. 2017;12:e0179862 pubmed publisher
    ..Understanding the mechanisms of omental metastases may enable us to discover new potential targets for therapy. ..
  37. Mao Y, Zeng L, Li Y, Liu Y, Wu J, Li L, et al. [Significance and expression of PAX8, PAX2, p53 and RAS in ovary and fallopian tubes to origin of ovarian high grade serous carcinoma]. Zhonghua Fu Chan Ke Za Zhi. 2017;52:687-696 pubmed publisher
    ..p53 and RAS in the above tissues and tissue microarray from ovarian and tubal of HGSC and control women by immunohistochemistry methods...
  38. Feijó E, Nery A, Caiado F, Limongi R. Solitary fibrous tumor of the lacrimal gland mimicking pleomorphic adenoma. Arq Bras Oftalmol. 2017;80:189-191 pubmed publisher
    ..We discuss the clinical, radiological, histopathological, and immunohistochemical findings that provided insight and rationale to accurately diagnose this case. ..
  39. Sun Y, Chen K, Imamura Kawasawa Y, Salzberg A, Cooper T, Caruso C, et al. Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene. PLoS ONE. 2017;12:e0186873 pubmed publisher
    ..was observed in protein expression between normal oral tissues treated with DBP or vehicle as examined by immunohistochemistry. Collectively, our results indicate that Fgf3 hypomethylation and gene overexpression, but not protein ..
  40. Cabahug Zuckerman P, Stout R, Majeska R, Thi M, Spray D, Weinbaum S, et al. Potential Role for a Specialized ?3 Integrin-Based Structure On Osteocyte Processes in Bone Mechanosensation. J Orthop Res. 2017;: pubmed publisher
    ..We analyzed these spatial relationships in mouse bone osteocytes using immunohistochemistry combined with Structured Illumination Super Resolution Microscopy, a method that permits structural ..
  41. Azad T, Janse van Rensburg H, Lightbody E, Neveu B, Champagne A, Ghaffari A, et al. A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis. Nat Commun. 2018;9:1061 pubmed publisher
    ..Thus, our work offers a biosensor tool for the study of the Hippo pathway and suggests a role for Hippo signaling in regulating blood vessel formation in physiological and pathological settings. ..
  42. Göppel J, Möckelmann N, Münscher A, Sauter G, Schumacher U. Expression of Epithelial-Mesenchymal Transition Regulating Transcription Factors in Head and Neck Squamous Cell Carcinomas. Anticancer Res. 2017;37:5435-5440 pubmed
    ..Twist is the major transcription factor active in HNSCC; the other transcription factors of EMT seem to be of less importance in this tumor entity. ..
  43. Raspotnig M, Haugen M, Thorsteinsdottir M, Stefansson I, Salvesen H, Storstein A, et al. Cerebellar degeneration-related proteins 2 and 2-like are present in ovarian cancer in patients with and without Yo antibodies. Cancer Immunol Immunother. 2017;66:1463-1471 pubmed publisher
    ..Clinical data were available for all patients. The human tissues were examined by western blot and immunohistochemistry using rabbit CDR2 and CDR2L antibodies...
  44. Russo M, Broach J, Sheldon K, Houser K, Liu D, Kesterson J, et al. Clonal evolution in paired endometrial intraepithelial neoplasia/atypical hyperplasia and endometrioid adenocarcinoma. Hum Pathol. 2017;67:69-77 pubmed publisher
    ..To investigate, we performed next-generation sequencing, copy number alteration (CNA) analysis, and immunohistochemistry for mismatch repair protein expression on EIN/AH and endometrioid adenocarcinoma samples from 6 ..
  45. Jeffus S, Gardner J, Steliga M, Shah A, Stelow E, Arnaoutakis K. Hyalinizing Clear Cell Carcinoma of the Lung: Case Report and Review of the Literature. Am J Clin Pathol. 2017;148:73-80 pubmed publisher
    ..Tumor cell appearance was clear to eosinophilic, lacking significant pleomorphism or mitotic activity. By immunohistochemistry, the tumor cells were strongly positive with antibodies to pan-keratin, p63, and CK5/6 while negative for ..
  46. Shanmugam V, Craig J, Hornick J, Morgan E, Pinkus G, Pozdnyakova O. Cyclin D1 Is Expressed in Neoplastic Cells of Langerhans Cell Histiocytosis but Not Reactive Langerhans Cell Proliferations. Am J Surg Pathol. 2017;41:1390-1396 pubmed publisher
    ..this study was to investigate cyclin D1 expression in LCH and reactive Langerhans cell accumulations using immunohistochemistry on archival tissue. All LCH cases tested (39/39) showed cyclin D1 expression in CD1a/Langerin cells...
  47. Delaney M, Wan Y, Kim G, Creighton C, Taylor M, Masand R, et al. A Role for Progesterone-Regulated sFRP4 Expression in Uterine Leiomyomas. J Clin Endocrinol Metab. 2017;102:3316-3326 pubmed publisher
    ..More work is needed to elucidate how progesterone's ability to modulate sFRP4 expression contributes to uterine smooth muscle tumorigenesis. ..
  48. Potula H, Richer L, Werts C, Gomes Solecki M. Pre-treatment with Lactobacillus plantarum prevents severe pathogenesis in mice infected with Leptospira interrogans and may be associated with recruitment of myeloid cells. PLoS Negl Trop Dis. 2017;11:e0005870 pubmed publisher
    ..b>Immunohistochemistry of kidney sections of pre-treated infected mice showed an enrichment of neutrophils and macrophages and a ..
  49. Ihara H, Kasamatsu S, Kitamura A, Nishimura A, Tsutsuki H, Ida T, et al. Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells. Chem Res Toxicol. 2017;30:1673-1684 pubmed publisher
    ..Our results suggest that reactive persulfide species may be potential therapeutic targets for attenuating cell injury by electrophiles. ..
  50. Chen Y, Zhang Y, Tan Y, Liu Z. Clinical significance of SPARC in esophageal squamous cell carcinoma. Biochem Biophys Res Commun. 2017;492:184-191 pubmed publisher
    ..levels of SPARC in cancer tissue and in adjacent normal mucosa were measured by qRT-PCR, western blot and immunohistochemistry (IHC). The mRNA and protein levels of SPARCwere5...
  51. Norum J, Skarpen E, Brech A, Kuiper R, Waaler J, Krauss S, et al. The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology. Biol Res. 2018;51:3 pubmed publisher
  52. Akiyama G, Azuchi Y, Guo X, Noro T, Kimura A, Harada C, et al. Edaravone Prevents Retinal Degeneration in Adult Mice Following Optic Nerve Injury. Invest Ophthalmol Vis Sci. 2017;58:4908-4914 pubmed publisher
    ..To assess the therapeutic potential of edaravone, a free radical scavenger that is used for the treatment of acute brain infarction and amyotrophic lateral sclerosis, in a mouse model of optic nerve injury (ONI)...
  53. Mastronikolis N, Tsiambas E, Papadas T, Karameris A, Ragos V, Peschos D, et al. Deregulation of PTEN Expression in Laryngeal Squamous Cell Carcinoma Based on Tissue Microarray Digital Analysis. Anticancer Res. 2017;37:5521-5524 pubmed
    ..b>Immunohistochemistry and digital image analysis were implemented for evaluating protein expression levels...
  54. Srisuwantha R, Shiheido Y, Aoyama N, Sato H, Kure K, Laosrisin N, et al. Porphyromonas Gingivalis Elevated High-Mobility Group Box 1 Levels After Myocardial Infarction in Mice. Int Heart J. 2017;58:762-768 pubmed publisher
    ..We determined the expression of HMGB1 by ELISA and immunohistochemistry.The level of HMGB1 protein in the P.g...
  55. Luchini C, Pea A, Lionheart G, Mafficini A, Nottegar A, Veronese N, et al. Pancreatic undifferentiated carcinoma with osteoclast-like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma. J Pathol. 2017;243:148-154 pubmed publisher
    ..Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  56. Li Y, Wang C, Cai W, Sengupta S, Zavortink M, Deng H, et al. H2Av facilitates H3S10 phosphorylation but is not required for heat shock-induced chromatin decondensation or transcriptional elongation. Development. 2017;144:3232-3240 pubmed publisher
    ..These data strongly suggest that H2Av or H3S10 phosphorylation by JIL-1 is not required for chromatin decondensation or transcriptional elongation in Drosophila. ..
  57. Ten Kate F, van Olphen S, Bruno M, Wijnhoven B, van Lanschot J, Looijenga L, et al. Loss of SRY-box2 (SOX2) expression and its impact on survival of patients with oesophageal adenocarcinoma. Br J Surg. 2017;104:1327-1337 pubmed publisher
    ..SOX2 was studied by immunohistochemistry in patients who had undergone potentially curative oesophagectomy for adenocarcinoma...
  58. Pulford E, Huilgol K, Moffat D, Henderson D, Klebe S. Malignant Mesothelioma, BAP1 Immunohistochemistry, and VEGFA: Does BAP1 Have Potential for Early Diagnosis and Assessment of Prognosis?. Dis Markers. 2017;2017:1310478 pubmed publisher
    ..Pathologists should employ caution when commenting on prognostic implications of BAP1 status of MM patients in diagnostic pathology reports, but it may be useful for early diagnosis...
  59. Jensen H, Login F, Park J, Kwon T, Nejsum L. Immunohistochemical evalulation of activated Ras and Rac1 as potential downstream effectors of aquaporin-5 in breast cancer in vivo. Biochem Biophys Res Commun. 2017;493:1210-1216 pubmed publisher
    ..b>Immunohistochemistry revealed that activation of Ras and Rac1 was positively correlated...
  60. Pickett J, Chou A, Andrici J, Clarkson A, Sioson L, Sheen A, et al. Inflammatory Myofibroblastic Tumors of the Female Genital Tract Are Under-recognized: A Low Threshold for ALK Immunohistochemistry Is Required. Am J Surg Pathol. 2017;41:1433-1442 pubmed publisher
    ..b>Immunohistochemistry (IHC) for ALK was performed on tissue microarrays of unselected tumors resected from 2009 to 2013...
  61. Xu X, Song N, Zhang X, Jiao X, Hu J, Liang M, et al. Renal Protection Mediated by Hypoxia Inducible Factor-1α Depends on Proangiogenesis Function of miR-21 by Targeting Thrombospondin 1. Transplantation. 2017;101:1811-1819 pubmed publisher
    ..HIF-1α induced angiogenesis by upregulating not only vascular endothelial growth factor but also miR-21 via inhibiting a novel target gene TSP-1. Both of them may contribute to the protective effect of HIF-1α on renal I/R injury. ..
  62. Suh J, Park J, Lee C, Moon K. Intrafocal heterogeneity of ERG protein expression and gene fusion pattern in prostate cancer. Prostate. 2017;77:1438-1445 pubmed publisher
    ..The aim of this study was to elucidate the intrafocal heterogeneity of ERG gene fusion status. ERG immunohistochemistry (IHC) was performed in samples from 168 prostate cancer patients who had undergone radical prostatectomy, ..
  63. Tanaka M, Kohashi K, Kushitani K, Yoshida M, Kurihara S, Kawashima M, et al. Inflammatory myofibroblastic tumors of the lung carrying a chimeric A2M-ALK gene: report of 2 infantile cases and review of the differential diagnosis of infantile pulmonary lesions. Hum Pathol. 2017;66:177-182 pubmed publisher
    ..We propose that these infantile pulmonary lesions containing a chimeric A2M-ALK gene be categorized as a specific type of inflammatory myofibroblastic tumor that develops exclusively in neonates and infants. ..
  64. Wang K, Peng B, Xiao J, Weinreb O, Youdim M, Lin B. Iron-Chelating Drugs Enhance Cone Photoreceptor Survival in a Mouse Model of Retinitis Pigmentosa. Invest Ophthalmol Vis Sci. 2017;58:5287-5297 pubmed publisher
    ..VK28 and VAR10303 provided partial histologic and functional rescue of cones in RD10 mice. Our study demonstrated that iron chelation therapy might represent an effective therapeutic strategy for RP patients. ..
  65. Peng Y, Wang S, Li K, Liu J, Zheng Y, Shan S, et al. Identification of odorant binding proteins and chemosensory proteins in Microplitis mediator as well as functional characterization of chemosensory protein 3. PLoS ONE. 2017;12:e0180775 pubmed publisher
    ..The MmedCSP3 may be involved in locating host insects. Our data provide a base for further investigating the physiological roles of OBPs and CSPs in M. mediator, and extend the function of MmedCSP3 in chemoreception of M. mediator. ..
  66. Haymerle G, Janik S, Fochtmann A, Pammer J, Schachner H, Nemec L, et al. Expression of Merkelcell polyomavirus (MCPyV) large T-antigen in Merkel cell carcinoma lymph node metastases predicts poor outcome. PLoS ONE. 2017;12:e0180426 pubmed publisher
    ..41 MCC patients were included. 33 (61%) out of 54 specimens were MCPyV-positive in the immunohistochemistry. 15 (47%) out of 32 primary tumors were positive compared to 18 (82%) out of 22 lymph node metastases...
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    ..the current literature on MAC pertaining to epidemiology, pathogenesis, clinical presentation, histology, immunohistochemistry, prognosis, follow-up, and treatment...
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    ..In conclusion, sirtuin 1 activation in Müller glial cells suppressed the development of choroidal neovascularization, and therefore, might be a therapeutic option. ..
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    ..from western Kenya with parental consent, diagnosis confirmed using histology and consensus panel of immunohistochemistry antibodies...
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    ..U/S, consisting of immunohistochemistry and reflex methylation analysis, was applied to 348 Asian ECs, and sporadic cancer (SC) cases were screened ..