targeted gene repair


Summary: A technique which uses synthetic oligonucleotides to direct the cell's inherent DNA repair system to correct a mutation at a specific site in an episome or chromosome.

Top Publications

  1. Baltimore D, Berg P, Botchan M, Carroll D, Charo R, Church G, et al. Biotechnology. A prudent path forward for genomic engineering and germline gene modification. Science. 2015;348:36-8 pubmed publisher
  2. Pollack R. Eugenics lurk in the shadow of CRISPR. Science. 2015;348:871 pubmed publisher
  3. Doudna J, Gersbach C. Genome editing: the end of the beginning. Genome Biol. 2015;16:292 pubmed publisher
  4. Järver P, O Donovan L, Gait M. A chemical view of oligonucleotides for exon skipping and related drug applications. Nucleic Acid Ther. 2014;24:37-47 pubmed publisher
  5. Keener A. Delivering the goods: scientists seek a way to make CRISPR-Cas gene editing more targeted. Nat Med. 2015;21:1239-41 pubmed publisher