Research Topics

Genomes and Genes

drug administration routes

Summary

Summary: The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue.

Webpages

  1. ischemia
    decabada.lib.bioinfo.pl/meid:47378

Publications

  1. Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing
    Carrie K Jones
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Neuropharmacology 49:206-18
  2. Ghrelin inhibits inflammatory pain in rats: involvement of the opioid system
    Valeria Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Via Vanvitelli, 32, 20129 Milan, Italy
    Neuropharmacology 51:497-505
  3. Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the rat
    David A Scott
    The Department of Pharmacology, University of Melbourne, Melbourne, Vic. 3010, Australia
    Pain 109:124-31
  4. Reversal of phencyclidine-induced dopaminergic dysregulation by N-methyl-D-aspartate receptor/glycine-site agonists
    Daniel C Javitt
    Nathan Kline Institute for Psychiatric Research, NYU School of Medicine, Orangeburg, NY, USA
    Neuropsychopharmacology 29:300-7
  5. Pharmacological characterisation of a rat model of incisional pain
    Garth T Whiteside
    Neuropharmacology, Purdue Pharma LP, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA
    Br J Pharmacol 141:85-91
  6. Cataleptic activity of the denatured venom of the social wasp Agelaia vicina (Hymenoptera, Vespidae) in Rattus norvegicus (Rodentia, Muridae)
    Luciana de Oliveira
    Neurobiology and Venoms Laboratory, Biology Department of the Faculty of Philosophy, Sciences and Literature of Ribeirão Preto, University of São Paulo, Ribeirão Preto (SP, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 30:198-203
  7. Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats
    Dong K Ahn
    Department of Oral Physiology, School of Dentistry, Kyungpook National University, 188 1 Sam Deok 2 ga, Chung gu, Daegu 700 412, South Korea
    Pain 117:204-13
  8. Elevated mu-opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate-dependent rats
    E J van Bockstaele
    Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Neurosci Res 83:508-14
  9. Pretreatment with subeffective doses of Rimonabant attenuates orexigenic actions of orexin A-hypocretin 1
    Inmaculada Crespo
    Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, Campus de Somosaguas E 28223 Madrid, Spain
    Neuropharmacology 54:219-25
  10. Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats
    Rajesh R Ugale
    Pharmacology Division, Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee 441 002, Nagpur, Maharashtra, India
    Brain Res 1184:193-201

Scientific Experts

Detail Information

Webpages1

  1. ischemia
    decabada.lib.bioinfo.pl/meid:47378

Publications62

  1. Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing
    Carrie K Jones
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Neuropharmacology 49:206-18
    ..The present findings indicate that group II (mGluR2/3) metabotropic glutamate receptors may be involved in the mechanisms of hyperalgesia and allodynia, however tolerance rapidly develops to these effects...
  2. Ghrelin inhibits inflammatory pain in rats: involvement of the opioid system
    Valeria Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Via Vanvitelli, 32, 20129 Milan, Italy
    Neuropharmacology 51:497-505
    ..c.), did not antagonize antinociception elicited by i.p. ghrelin. Overall these data indicate that ghrelin exerts an inhibitory role on inflammatory pain through an interaction with the central opioid system...
  3. Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the rat
    David A Scott
    The Department of Pharmacology, University of Melbourne, Melbourne, Vic. 3010, Australia
    Pain 109:124-31
    ..005). These results suggest a role for CB-2 receptor-mediated antinociception in both acute and neuropathic pain in addition to centrally located CB-1 mechanisms...
  4. Reversal of phencyclidine-induced dopaminergic dysregulation by N-methyl-D-aspartate receptor/glycine-site agonists
    Daniel C Javitt
    Nathan Kline Institute for Psychiatric Research, NYU School of Medicine, Orangeburg, NY, USA
    Neuropsychopharmacology 29:300-7
    ..These findings demonstrate effective doses of glycine for use in animal models of schizophrenia, and support recent clinical studies showing the effectiveness of NMDA agonists in the treatment of persistent symptoms of schizophrenia...
  5. Pharmacological characterisation of a rat model of incisional pain
    Garth T Whiteside
    Neuropharmacology, Purdue Pharma LP, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA
    Br J Pharmacol 141:85-91
    ....
  6. Cataleptic activity of the denatured venom of the social wasp Agelaia vicina (Hymenoptera, Vespidae) in Rattus norvegicus (Rodentia, Muridae)
    Luciana de Oliveira
    Neurobiology and Venoms Laboratory, Biology Department of the Faculty of Philosophy, Sciences and Literature of Ribeirão Preto, University of São Paulo, Ribeirão Preto (SP, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 30:198-203
    ..However, the association of haloperidol and denatured venom was reverted by theophylline but not by ketamine. These findings suggest that A. vicina venom may affect neural substrates involved with catalepsy in the central nervous system...
  7. Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats
    Dong K Ahn
    Department of Oral Physiology, School of Dentistry, Kyungpook National University, 188 1 Sam Deok 2 ga, Chung gu, Daegu 700 412, South Korea
    Pain 117:204-13
    ..It is concluded that central acting of COX-3 inhibitors may be of therapeutic value in the treatment of inflammatory pain in TMJ...
  8. Elevated mu-opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate-dependent rats
    E J van Bockstaele
    Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Neurosci Res 83:508-14
    ....
  9. Pretreatment with subeffective doses of Rimonabant attenuates orexigenic actions of orexin A-hypocretin 1
    Inmaculada Crespo
    Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, Campus de Somosaguas E 28223 Madrid, Spain
    Neuropharmacology 54:219-25
    ....
  10. Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats
    Rajesh R Ugale
    Pharmacology Division, Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee 441 002, Nagpur, Maharashtra, India
    Brain Res 1184:193-201
    ..Thus, our results provide behavioral evidence for the role of neurosteroids like ALLO in the anti-anxiety effect of etifoxine...
  11. Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat
    Elizabeth K Joseph
    Department of Medicine, Division of Neuroscience and Biomedical Sciences Program, and UCSF NIH Pain Center, University of California, San Francisco, CA 94143 0440, USA
    Pain 107:147-58
    ..This study provides evidence for a novel, calcium-dependent, mechanism for neuropathic pain in a model of AIDS therapy-induced painful peripheral neuropathy...
  12. Antihyperalgesic effects of loperamide in a model of rat neuropathic pain are mediated by peripheral delta-opioid receptors
    Katsumi Shinoda
    Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, 1188 Shimotogari, Nagaizumi cho, Sunto gun, Shizuoka ken 411 8731, Japan
    Neurosci Lett 411:143-6
    ....
  13. Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats
    Emily M Jutkiewicz
    Department of Pharmacology, University of Michigan Medical School, 1301 MSRB III, Ann Arbor, MI 48109 0632, USA
    Psychopharmacology (Berl) 182:588-96
    ....
  14. Roles of opioid receptor subtypes on the antinociceptive effect of intrathecal sildenafil in the formalin test of rats
    Myung Ha Yoon
    Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, Gwangju, Republic of Korea
    Neurosci Lett 441:125-8
    ..Both mu and delta opioid receptors are involved. However, it seems that kappa opioid receptors play in the effect of sildenafil...
  15. 18-MC acts in the medial habenula and interpeduncular nucleus to attenuate dopamine sensitization to morphine in the nucleus accumbens
    Olga D Taraschenko
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    Synapse 61:547-60
    ..The results suggest that 18-MC acts in the habenulo-interpeduncular pathway to modulate the effects of repeated morphine in the dopaminergic mesolimbic system...
  16. Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release
    Ichiro Kondo
    Department of Anesthesiology, University of California-San Diego, La Jolla, California 92093, USA
    J Neurosci 25:3651-60
    ..All effects were reversed by naloxone. These results indicate that lumbar opiates inhibit noxious stimuli-induced neurotransmitter release from primary afferents at doses that are confirmed behaviorally as analgesic...
  17. Behavioural effects of the novel AMPA/GluR5 selective receptor antagonist NS1209 after systemic administration in animal models of experimental pain
    Gordon Blackburn Munro
    Department of Pharmacology, Neurosearch A S, Pederstrupvej 93, DK 2750 Ballerup, Denmark
    Neuropharmacology 47:351-62
    ..Thus, systemic administration of NS1209 at non-ataxic doses has marked analgesic actions comparable to those of morphine in a range of animal models of experimental pain...
  18. Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia
    F C Colpaert
    Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres Cedex, France
    Neuropharmacology 43:945-58
    ....
  19. Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system
    Roberto Ciccocioppo
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy
    Biol Psychiatry 61:4-12
    ..We suggest that NOP agonistic properties of buprenorphine might be useful in the treatment of alcoholism...
  20. U-69593, a kappa opioid receptor agonist, decreases cocaine-induced behavioral sensitization in female rats
    Anabel Puig Ramos
    Department of Physiology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico
    Behav Neurosci 122:151-60
    ..This decrease in cocaine-induced hyperlocomotion persisted after 1 week of cocaine withdrawal. These data indicate that the KOPr system participates in estradiol modulation of cocaine-induced behavioral sensitization in the female rat...
  21. DAMGO and 6beta-glycine substituted 14-O-methyloxymorphone but not morphine show peripheral, preemptive antinociception after systemic administration in a mouse visceral pain model and high intrinsic efficacy in the isolated rat vas deferens
    Mahmoud Al Khrasani
    Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
    Brain Res Bull 74:369-75
    ..Our findings support the role of peripheral MOR in the pathology of pain states involving sensitization of peripheral nociceptors...
  22. Teneurin proteins possess a carboxy terminal sequence with neuromodulatory activity
    Liqun Wang
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Canada M5S 3G5
    Brain Res Mol Brain Res 133:253-65
    ..These data indicate that TCAP may possess functions that are independent of the teneurin proprotein and together, the teneurins and TCAP, may represent a novel system to regulate neuronal function and emotionality...
  23. Intraseptal infusion of oxotremorine impairs memory in a delayed-non-match-to-sample radial maze task
    J G Bunce
    Department of Psychology, University of Connecticut, Storrs, CT 06269, USA
    Neuroscience 121:259-67
    ....
  24. Antiallodynic effects of NMDA glycine(B) antagonists in neuropathic pain: possible peripheral mechanisms
    Thomas Christoph
    Department of Pharmacology, Grünenthal GmbH R and D, Zieglerstr. 6, 52078 Aachen, Germany
    Brain Res 1048:218-27
    ..Thus, peripheral NMDA receptors may substantially contribute to the efficacy of NMDA antagonists in neuropathic pain...
  25. Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats
    Mary M Torregrossa
    Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA
    Brain Res 1069:172-81
    ....
  26. Continuous perfusion with morphine of the orbitofrontal cortex reduces allodynia and hyperalgesia in a rat model for mononeuropathy
    Hassen A Al Amin
    Department of Psychiatry, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
    Neurosci Lett 364:27-31
    ..The observed results support the idea that this area is a component of a flexible cerebral network involved in pain processing and perception...
  27. The role of NR2B containing NMDA receptor in place preference conditioned with morphine and natural reinforcers in rats
    Yao-Ying Ma
    Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, Key Laboratory of Neuroscience, The Ministry of Education and Ministry of Public Health, 38 Xueyuan Road, Beijing 100083, PR China
    Exp Neurol 200:343-55
    ..Taking together, these findings suggested that NR2B containing NMDA receptor may be more involved with morphine reward rather than natural rewards, and that antagonism of NR2B may have a potential for the treatment of morphine abuse...
  28. NPY mediates the feeding elicited by muscimol injections into the nucleus accumbens shell
    Thomas R Stratford
    Laboratory of Integrative Neuroscience and Department of Psychology m c 285, University of Illinois at Chicago, 1007 W Harrison Street, Chicago, IL 60607, USA
    Neuroreport 15:2673-6
    ..Intra-AcbSh muscimol elicited a large increase in food intake which was potently suppressed by blocking either central Y1 or Y5 receptors. Our results suggest that the AcbSh influences food intake, in part, through the release of NPY...
  29. Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversion
    Karine Guillem
    Laboratoire de Neuropsychobiologie des Désadaptations UMR CNRS 5541, Université de Bordeaux 2, Bordeaux, France
    Biol Psychiatry 63:158-63
    ....
  30. Modulation of NMDA receptors by intrathecal administration of the sensory neuron-specific receptor agonist BAM8-22
    Tingjun Chen
    College of Life Sciences and Provincial Key Laboratory of Developmental Biology Neuroscience, Fujian Normal University Fuzhou, Fujian 350108, People s Republic of China
    Neuropharmacology 54:796-803
    ..Taken together, these data suggest that the activation of SNSR induces spinal analgesia by suppressing NMDA receptor-mediated activation of spinal dorsal horn neurons and an increase in NOS activity...
  31. The acute and chronic administration of (+/-)-8-hydroxy-2-(Di-n-propylamino)tetralin significantly alters the activity of spontaneously active midbrain dopamine neurons in rats: an in vivo electrophysiological study
    Kazuhiko Nakamura
    Department of Psychiatry, Hamamatsu University School of Medicine 1-20-1, Handayama, Hamamatsu, 431-3192, Shizuoka, Japan
    Synapse 59:359-67
    ..01 and 0.1 mg/kg, but significantly decreased by 1 mg/kg of 8-OH-DPAT. Overall, the systemic administration of 8-OH-DPAT preferentially affects the activity of spontaneously active A10 DA neurons in rats...
  32. The possible role of the NO-cGMP pathway in nociception: different spinal and supraspinal action of enzyme blockers on rat dorsal horn neurones
    Ulrich Hoheisel
    Institut für Pharmakologie und Toxikologie, Charit, Humboldt-Universität, Berlin, Germany
    Pain 117:358-67
    ..The results show that at the spinal level, a lack of cGMP and NO has an excitatory action on dorsal horn neurones, whereas supraspinally an elevated level of cGMP is excitatory...
  33. A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation
    A G Nackley
    Neuroscience and Behavior Program, Department of Psychology, The University of Georgia, Athens, GA 30602-3013, USA
    Neuroscience 117:659-70
    ....
  34. Rats maintained chronically on buprenorphine show reduced heroin and cocaine seeking in tests of extinction and drug-induced reinstatement
    Robert E Sorge
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada
    Neuropsychopharmacology 30:1681-92
    ....
  35. Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats
    William A Carlezon
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    Biol Psychiatry 57:343-50
    ..CONCLUSIONS: Uridine and OMG each have antidepressant-like effects in rats. Less of each agent is required for effectiveness when the treatments are administered together...
  36. Prolonged nicotine dependence associated with extended access to nicotine self-administration in rats
    Neil E Paterson
    Department of Neuropharmacology CVN-7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 173:64-72
    ....
  37. ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia in a rat chemotherapy-induced pain model
    James J Lynch
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Department R4N5, Bldg AP9A LL, 100 Abbott Park Road, Abbott Park, IL 60064 6115, USA
    Eur J Pharmacol 509:43-8
    ....
  38. Spinal and local peripheral antiallodynic activity of Ro64-6198 in neuropathic pain in the rat
    Ilona Obara
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343 Krakow, Poland
    Pain 116:17-25
    ..Therefore, besides spinal, also peripheral ORL1 receptors may be targeted by drugs designed for the long-term treatment of chronic pain...
  39. Limited brain diffusion of the glucocorticoid receptor agonist RU28362 following i.c.v. administration: implications for i.c.v. drug delivery and glucocorticoid negative feedback in the hypothalamic-pituitary-adrenal axis
    A B Francis
    Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309, USA
    Neuroscience 141:1503-15
    ....
  40. MGlu5 antagonism impairs exploration and memory of spatial and non-spatial stimuli in rats
    Gert R J Christoffersen
    Department of Biology, August Krogh Building, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Behav Brain Res 191:235-45
    ..However, the fact that prelimbic administration of MPEP inhibited retention without reducing exploration shows that memory formation was also impacted directly by prelimbic mGlu5 in both spatial and non-spatial learning...
  41. Importance of cocaine- and amphetamine-regulated transcript peptide in the central nucleus of amygdala in anxiogenic responses induced by ethanol withdrawal
    Manoj P Dandekar
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University Campus, Nagpur, India
    Neuropsychopharmacology 33:1127-36
    ..We suggest that CART may mediate the early signs of anxiety-like behavior induced by ethanol withdrawal within the neuroanatomical framework of the CeA...
  42. Effects of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on the antinociceptive activity of pethidine administered at the peripheral and supraspinal level
    Cai Yun Fu
    Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, Lanzhou University, 222 Tian Shui South Road, Lanzhou 730000, People s Republic of China
    Behav Brain Res 184:39-46
    ..Our results may pave the way for a new strategy for the control of pain and may provide a clinical strategy to enable selection of either opioid as a priority...
  43. Behavioral effects of intracerebroventricular microinfusion of agmatine in adult rats
    Ping Liu
    Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Behav Neurosci 122:557-69
    ..These results suggest that the behavioral effects of agmatine are task- and dose-dependent, and agmatine may be an anxiolytic and memory modulator...
  44. Fluoxetine administration potentiates the effect of olanzapine on locus coeruleus neuronal activity
    Matthew A Seager
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Biol Psychiatry 55:1103-9
    ..g., prefrontal cortex), which could lead to a reduction in depressive symptoms...
  45. Blockade of peripheral 5HT3 receptor attenuates the formalin-induced nocifensive behavior in persistent temporomandibular joint inflammation of rat
    Keiichiro Okamoto
    Department of Anatomy and Neurobiology, Wakayama Medical University, Kimiidera 811-1, Wakayama City 640-0012, Japan
    Neurosci Lett 367:259-63
    ....
  46. Effects of central leptin infusion on the reward-potentiating effect of D-amphetamine
    Joy Hao
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Brain Res 1087:123-33
    ..Together, results of this study support the importance of weight loss, but not leptin, in the enhancement of drug reward sensitivity...
  47. Effects of cocaine in rats exposed to heroin
    Francesco Leri
    Department of Psychology, University of Guelph, Canada
    Neuropsychopharmacology 28:2102-16
    ..In response to cocaine, however, DA activity in the Acb was significantly lower in rats withdrawn from the highest dose of heroin...
  48. Roles of peripheral mitogen-activated protein kinases in melittin-induced nociception and hyperalgesia
    J Hao
    Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders, Tangdu Hospital, Fourth Military Medical University, 1 Xinsi Road, Baqiao District, Xi an 710038, PR China
    Neuroscience 152:1067-75
    ..However, they are not likely to be involved in the processing of melittin-induced primary mechanical hyperalgesia, implicating a mechanistic separation between mechanical and thermal hyperalgesia in the periphery...
  49. Peripheral and central sites of action for A-85380 in the spinal nerve ligation model of neuropathic pain
    Lynne E Rueter
    Neurological Research, D4N5 AP9A, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6115, USA
    Pain 103:269-76
    ..Together these data further support the idea that different mechanisms underlie different pain states and suggest that the effects of NNR agonists in neuropathic pain may be due in part to peripheral actions of the compounds...
  50. Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease
    Nicola Simola
    Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, 09124 Cagliari, Italy
    J Neurol Sci 248:48-52
    ..The prospective of providing additional antitremor benefits considerably enhances the therapeutic potential of A(2A) antagonists...
  51. Neuroprotection by tamoxifen in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activity
    Yonghua Zhang
    Neural and Vascular Biology Theme, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA
    Exp Neurol 204:819-27
    ..These data are consistent with at least part of tamoxifen's marked neuroprotection in focal cerebral ischemic injury being due to its antioxidant activity but not by an acute action on estrogen receptors (212 words)...
  52. Noradrenaline transporter blockers raise extracellular dopamine in medial prefrontal but not parietal and occipital cortex: differences with mianserin and clozapine
    V Valentini
    Department of Toxicology and Centre of Excellence Neurobiology of Addiction, University of Cagliari, Cagliari, Italy
    J Neurochem 88:917-27
    ..This process, although extensive in the PFCX, appears insignificant in the ParCX and OccCX, probably as a result of the higher ratio of NA to DA resulting in exclusion of DA from NA transporter...
  53. The effects of endogenous interleukin-1 bioactivity on locus coeruleus neurons in response to bacterial and viral substances
    Mark K Borsody
    Department of Psychiatry and Behavioral Sciences, Emory University Medical School, Emory West Campus, 1256 Briarcliff Road, Atlanta, GA 30306, USA
    Brain Res 1007:39-56
    ..In contrast, poly(I)/(C) increased the activity of LC neurons but this did not critically involve IL-1 receptors in the LC...
  54. Effects on cocaine and food self-administration of (+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, in rats
    Luigi Cervo
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Psychopharmacology (Berl) 173:124-31
    ..CONCLUSIONS: (+)-HA-966 reduced responding maintained by cocaine or food. Whether (+)-HA-966 induces a general motivational rather than a performance deficit, leading to reduced responding for either cocaine and food, is unclear...
  55. Neuroprotection and functional recovery conferred by administration of kappa- and delta 1-opioid agonists in a rat model of global ischemia
    Charlaine Charron
    University of Ottawa, School of Psychology, Ottawa, ON, Canada K1N 9A9
    Physiol Behav 93:502-11
    ..Similar to U50,488H, DPDPE had no significant impact on locomotor activity. These findings support a role for kappa- and delta-opioid receptors in attenuation of ischemia-induced hippocampal damage and cognitive impairments...
  56. Further evidence for the mediation of both subtypes of dopamine D1/D2 receptors and cerebral neuropeptide Y (NPY) in amphetamine-induced appetite suppression
    Dong Yih Kuo
    Department of Physiology, Chung Shan Medical University, Taichung City, Taiwan 402, ROC
    Behav Brain Res 147:149-55
    ..Taken together, the present results confirmed that both subtypes of D1 and D2 receptors and cerebral NPY were involved in the anorectic action of AMPH...
  57. The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice
    Neil E Paterson
    Department of Neuropharmacology, CVN-7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 167:257-64
    ..It is postulated that mGluR5 plays an essential role in mediating the reinforcing effects of nicotine, possibly but not exclusively, via modulation of mesolimbic dopaminergic neurotransmission...
  58. Systemic administration of a dopamine, but not a serotonin or norepinephrine, transporter inhibitor reinstates cocaine seeking in the rat
    Heath D Schmidt
    Laboratory of Neuropsychopharmacology, Department of Pharmacology, L 603, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Behav Brain Res 175:189-94
    ..These results suggest that increases in extracellular concentrations of dopamine, specifically in the nucleus accumbens shell, are primarily responsible for promoting cocaine priming-induced reinstatement of drug seeking in rats...
  59. Increased nociceptive response in mice lacking the adenosine A1 receptor
    Wei ping Wu
    Department of Neurotec, Division of Clinical Neurophysiology, Karolinska Institutet, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    Pain 113:395-404
    ..A1 receptors also contribute to the antinociceptive effect of spinal morphine. Selective A1 receptor agonists may be tested clinically as analgesics, particularly under conditions of neuropathic pain...
  60. Inhibition of [18F]FP-TZTP binding by loading doses of muscarinic agonists P-TZTP or FP-TZTP in vivo is not due to agonist-induced reduction in cerebral blood flow
    Kazuaki Shimoji
    Positron Emission Tomography Department, Clinical Center, NIMH, National Institutes of Health, Bethesda, Maryland 20892, USA
    Synapse 50:151-63
    ..The methods employed here may also be of interest to evaluate physiological effects of blocking agents utilized to validate other radiopharmaceuticals...
  61. Effects and mechanisms of supraspinal administration of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on nociception in mice
    Cai-Yun Fu
    Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, 222 Tian Shui South Road, Lanzhou 730000, People's Republic of China
    Brain Res 1056:51-8
    ..c.v. administration of r/m HK-1...