parasite load


Summary: Measure of the number of the PARASITES present in a host organism.

Top Publications

  1. Gonçalves B, Fried M, Duffy P. Parasite burden and severity of malaria in Tanzanian children. N Engl J Med. 2014;371:482 pubmed publisher
  2. Augusto R, Tetreau G, Chan P, Walet Balieu M, Mello Silva C, Santos C, et al. Double impact: natural molluscicide for schistosomiasis vector control also impedes development of Schistosoma mansoni cercariae into adult parasites. PLoS Negl Trop Dis. 2017;11:e0005789 pubmed publisher
    ..milii latex in Brazil and other endemic countries as cheap alternative or complement to mass drug treatment with Praziquantel, the only available drug to cure the patients (without preventing re-infection). ..
  3. Munde E, Okeyo W, Raballah E, Anyona S, Were T, Ong echa J, et al. Association between Fc? receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya. BMC Infect Dis. 2017;17:289 pubmed publisher
    ..The study revealed that haplotypes of Fc?Rs are important in conditioning susceptibility to SMA in immune-naive children from P. falciparum holoendemic region of western Kenya. ..
  4. Kaushal H, Bhattacharya S, Verma S, Salotra P. Serological and Molecular Analysis of Leishmania Infection in Healthy Individuals from Two Districts of West Bengal, India, Endemic for Visceral Leishmaniasis. Am J Trop Med Hyg. 2017;96:1448-1455 pubmed publisher
    ..Real-time quantitative polymerase chain reaction (qPCR) was performed for the quantification of parasite load in the blood...
  5. Segarra S, Miró G, Montoya A, Pardo Marín L, Boque N, Ferrer L, et al. Randomized, allopurinol-controlled trial of the effects of dietary nucleotides and active hexose correlated compound in the treatment of canine leishmaniosis. Vet Parasitol. 2017;239:50-56 pubmed publisher
    ..This combination could be a good alternative to MGA-allopurinol combination treatment for CanL, especially for dogs suffering allopurinol-related adverse events. ..
  6. Mittra B, Laranjeira Silva M, Miguel D, Perrone Bezerra de Menezes J, Andrews N. The iron-dependent mitochondrial superoxide dismutase SODA promotes Leishmania virulence. J Biol Chem. 2017;292:12324-12338 pubmed publisher
  7. Solana J, Ramírez L, Corvo L, de Oliveira C, Barral Netto M, Requena J, et al. Vaccination with a Leishmania infantum HSP70-II null mutant confers long-term protective immunity against Leishmania major infection in two mice models. PLoS Negl Trop Dis. 2017;11:e0005644 pubmed publisher
    ..These responses are able to confer long-term protection in mice against the infection of L. major virulent parasites. ..
  8. Peniche A, Bonilla D, Palma G, Melby P, Travi B, Osorio E. A secondary wave of neutrophil infiltration causes necrosis and ulceration in lesions of experimental American cutaneous leishmaniasis. PLoS ONE. 2017;12:e0179084 pubmed publisher
    ..The overall results indicate that neutrophils were unable to clear the infection in this model, and that the second wave of neutrophils played an important role in the severity of ACL. ..
  9. Chakraborty A, Kurati S, Mahata S, Sundar S, Roy S, Sen M. Wnt5a Signaling Promotes Host Defense against Leishmania donovani Infection. J Immunol. 2017;199:992-1002 pubmed publisher
    ..RNA transfection in vitro or by use of inhibitor of Wnt production in vivo led to an increase in cellular parasite load. In contrast, treatment of macrophages with recombinant Wnt5a caused a decrease in the load of antimony-..

More Information


  1. Wu X, Dayanand K, Thylur R, Norbury C, Gowda D. Small molecule-based inhibition of MEK1/2 proteins dampens inflammatory responses to malaria, reduces parasite load, and mitigates pathogenic outcomes. J Biol Chem. 2017;292:13615-13634 pubmed publisher
    ..In summary, we have identified several previously unrecognized immune regulatory processes through which a MEK1/2 inhibitor approach controls malaria parasitemia and mitigates pathogenic effects on host organs. ..
  2. Yamamoto L, Targa L, Sumita L, Shimokawa P, Rodrigues J, Kanunfre K, et al. Association of Parasite Load Levels in Amniotic Fluid With Clinical Outcome in Congenital Toxoplasmosis. Obstet Gynecol. 2017;130:335-345 pubmed publisher
    To correlate neonatal and infant clinical outcome with parasite load in amniotic fluid (AF). We conducted a retrospective cohort study of 122 children whose mothers had toxoplasmosis during pregnancy...
  3. Pineda C, Aguilera Tejero E, Morales M, Belinchon Lorenzo S, Gomez Nieto L, Garcia P, et al. Treatment of canine leishmaniasis with marbofloxacin in dogs with renal disease. PLoS ONE. 2017;12:e0185981 pubmed publisher
    ..0±18.1 to 54.1±18.0 g/L; p = 0.005). The results demonstrate that, in addition to being effective for treatment of CanL, marbofloxacin is a very safe drug in dogs with CKD and leishmaniasis...
  4. Ramesh V, Avishek K, Sharma V, Salotra P. Combination therapy with amphotericin-B and miltefosine for post-kala-azar dermal leishmaniasis: a preliminary report. Acta Derm Venereol. 2014;94:242-3 pubmed publisher
  5. Oliveira Ribeiro C, Pimentel M, Oliveira R, Fagundes A, Madeira M, Mello C, et al. Clinical and laboratory profiles of patients with early spontaneous healing in cutaneous localized leishmaniasis: a historical cohort study. BMC Infect Dis. 2017;17:559 pubmed publisher
  6. Nzoumbou Boko R, De Muylder G, Semballa S, Lecordier L, Dauchy F, Gobert A, et al. Trypanosoma musculi Infection in Mice Critically Relies on Mannose Receptor-Mediated Arginase Induction by a TbKHC1 Kinesin H Chain Homolog. J Immunol. 2017;199:1762-1771 pubmed publisher
    ..growth involved C-type lectin receptors, because mannose injection decreased arginase activity induction and parasite load in vitro and in vivo. Accordingly, the parasite load was reduced in mice lacking mannose receptor C-type 1...
  7. Badirzadeh A, Taheri T, Taslimi Y, Abdossamadi Z, Heidari Kharaji M, Gholami E, et al. Arginase activity in pathogenic and non-pathogenic species of Leishmania parasites. PLoS Negl Trop Dis. 2017;11:e0005774 pubmed publisher
    ..However, in L. major infected BALB/c mice, the induction of ARG and parasite load increased simultaneously according to the time course of infection, whereas in C57BL/6 mice, the enzyme is ..
  8. Wanji S, Eyong E, Tendongfor N, Ngwa C, Esuka E, Kengne Ouafo A, et al. Ivermectin treatment of Loa loa hyper-microfilaraemic baboons (Papio anubis): Assessment of microfilarial load reduction, haematological and biochemical parameters and histopathological changes following treatment. PLoS Negl Trop Dis. 2017;11:e0005576 pubmed publisher
    ..The utilization of this experimental model can contribute to the improved management of the adverse responses in humans. ..
  9. Kalinda C, Chimbari M, Mukaratirwa S. Effect of temperature on the Bulinus globosus - Schistosoma haematobium system. Infect Dis Poverty. 2017;6:57 pubmed publisher
    ..This has implications on transmission of schistosomiasis in the context of global warming. ..
  10. Oliveira V, Boechat V, Mendes Júnior A, Madeira M, Ferreira L, Figueiredo F, et al. Occurrence of Leishmania infantum in the central nervous system of naturally infected dogs: Parasite load, viability, co-infections and histological alterations. PLoS ONE. 2017;12:e0175588 pubmed publisher
    ..Additionally, L. infantum can cause inflammation in the CNS that can lead to neurological signs with progression of the disease. ..
  11. Barash N, Maloney J, Singer S, Dawson S. Giardia Alters Commensal Microbial Diversity throughout the Murine Gut. Infect Immun. 2017;85: pubmed publisher
    ..Shifts in the commensal microbiota may explain observed variations in giardiasis between hosts with respect to host pathology, degree of parasite colonization, infection initiation, and eventual clearance. ..
  12. Melo T, Sena I, Araujo N, Fonseca C. Antibodies are involved in the protective immunity induced in mice by Schistosoma mansoni schistosomula tegument (Smteg) immunization. Parasite Immunol. 2014;36:107-11 pubmed
    ..These results demonstrate that antibodies specific to surface tegumental antigens are involved in parasite elimination in mice immunized with Smteg. ..
  13. Kouam M, Tchatchueng Mbougua J, Demanou M, Boussinesq M, Pion S, Kamgno J. Impact of repeated ivermectin treatments against onchocerciasis on the transmission of loiasis: an entomologic evaluation in central Cameroon. Parasit Vectors. 2013;6:283 pubmed publisher
    ..loa is still active. This is an indication that the risk of occurrence of severe adverse events such as fatal encephalopathies is still present, especially for heavily microfilaria-loaded people taken ivermectin for the first time. ..