molecular imprinting


Summary: A methodology for chemically synthesizing polymer molds of specific molecules or recognition sites of specific molecules. Applications for molecularly imprinted polymers (MIPs) include separations, assays and biosensors, and catalysis.

Top Publications

  1. Paul P, Treetong A, Suedee R. Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system. Acta Pharm. 2017;67:149-168 pubmed publisher
    ..These MIPs, prepared as nanosized material, may open a new horizon for oral insulin delivery. ..
  2. Zhang C, Cui H, Han Y, Yu F, Shi X. Development of a biomimetic enzyme-linked immunosorbent assay based on molecularly imprinted polymers on paper for the detection of carbaryl. Food Chem. 2018;240:893-897 pubmed publisher
    ..944). The established method of MIPs-paper BELISA exhibits the advantages of low cost, higher stability and being re-generable, which can be applied as a convenient tool for the fast and efficient detection of carbaryl. ..
  3. Gutierrez Climente R, Gómez Caballero A, Guerreiro A, Garcia Mutio D, Unceta N, Goicolea M, et al. Molecularly imprinted nanoparticles grafted to porous silica as chiral selectors in liquid chromatography. J Chromatogr A. 2017;1508:53-64 pubmed publisher
    ..5 to 103.7% with RSD values that were below 10% in all tested concentration levels (0.1, 0.75 and 5?gmL-1), which confirmed method suitability for the intended application. ..
  4. Zhou T, Ding J, Ni L, Yu J, Li H, Ding H, et al. Preparation of magnetic superhydrophilic molecularly imprinted resins for detection of triazines in aqueous samples. J Chromatogr A. 2017;1497:38-46 pubmed publisher
    ..38?gL-1). At the spiked level (5?gL-1), the recoveries are in the range of 85-101% with the RSDs ?7%. This work provided a novel and efficient approach for the detection of triazines in aqueous samples. ..
  5. da Silva A, de Oliveira H, Silva C, Fonseca M, Pereira T, Nascimento C, et al. Efficient molecularly imprinted polymer as a pipette-tip solid-phase sorbent for determination of carvedilol enantiomers in human urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1061-1062:399-410 pubmed publisher
    ..99 for both enantiomers. The method was applied successfully in a preliminary study of urinary excretion after administration of CAR racemate to a healthy volunteer. ..
  6. Chen G, Jin M, Du P, Zhang C, Cui X, Zhang Y, et al. A sensitive chemiluminescence enzyme immunoassay based on molecularly imprinted polymers solid-phase extraction of parathion. Anal Biochem. 2017;530:87-93 pubmed publisher
    ..Therefore, the CLEIA method have successfully applied MIPs in sample pretreatment to eliminate matrix interference effects and provided a new sensitive assay for agro-products. ..
  7. Zhang W, Han Y, Chen X, Luo X, Wang J, Yue T, et al. Surface molecularly imprinted polymer capped Mn-doped ZnS quantum dots as a phosphorescent nanosensor for detecting patulin in apple juice. Food Chem. 2017;232:145-154 pubmed publisher
    ..of patulin (PAT) was synthesized with 6-hydroxynicotinic acid (6-HNA) as dummy template via a surface molecular imprinting sol-gel process...
  8. Brigante T, Miranda L, de Souza I, Acquaro Junior V, Queiroz M. Pipette tip dummy molecularly imprinted solid-phase extraction of Bisphenol A from urine samples and analysis by gas chromatography coupled to mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1067:25-33 pubmed publisher
    ..The developed method was linear from 50 to 500ngmL-1. Precision values had coefficient of variation (CV) ranging from 4 to 14%. The accuracy relative standard deviation values (RSD) varied from -13.6 to 12.3%...
  9. Soleimani E, Bahrami A, Afkhami A, Shahna F. Determination of urinary trans,trans-muconic acid using molecularly imprinted polymer in microextraction by packed sorbent followed by liquid chromatography with ultraviolet detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1061-1062:65-71 pubmed publisher
    ..4-4.7% and 3.5-6.6%, respectively. Accuracy was -8.4 to -10.2% in urine samples. The developed method is suggested as an alternative to existing conventional SPE methods for biomonitoring of benzene-exposed subjects. ..

More Information


  1. Liu H, Zhou K, Chen X, Wang J, Wang S, Sun B. Graphene oxide-sensitized molecularly imprinted opto-polymers for charge-transfer fluorescent sensing of cyanoguanidine. Food Chem. 2017;235:14-20 pubmed publisher
    ..b>Molecular imprinting was used to construct molecular-scale analyte-selective cavities, graphene oxide was introduced to provide ..
  2. Wang H, Liu Y, Yao S, Zhu P. Selective recognization of dicyandiamide in bovine milk by mesoporous silica SBA-15 supported dicyandiamide imprinted polymer based on surface molecularly imprinting technique. Food Chem. 2018;240:1262-1267 pubmed publisher
    ..08?g/mL (bovine milk) and 0.10?g/mL (milk powder). These results indicated that SBA-15@MIP could be used as an efficient SPE adsorbent for enrichment of DCD in bovine milk and milk powder. ..
  3. Xu J, Medina Rangel P, Haupt K, Tse Sum Bui B. Guide to the Preparation of Molecularly Imprinted Polymer Nanoparticles for Protein Recognition by Solid-Phase Synthesis. Methods Enzymol. 2017;590:115-141 pubmed publisher
    ..Nowadays, molecular imprinting of proteins still remains a challenge as the generation of selective imprinted cavities is extremely ..
  4. Serrels K, Erington K, Bodoh D, Farrell C, Leslie N, Lundquist T, et al. Two-photon laser-assisted device alteration in silicon integrated-circuits. Opt Express. 2013;21:29083-9 pubmed publisher
    ..Together, the exceptional spatial and temporal resolutions demonstrated here now make it possible to extend optical fault localization to sub-14 nm technology nodes. ..
  5. Lu H, Xu S. Hollow mesoporous structured molecularly imprinted polymers for highly sensitive and selective detection of estrogens from food samples. J Chromatogr A. 2017;1501:10-17 pubmed publisher
    ..3% were obtained. The limits of detection for these estrogens were in the range of 33-22ngL-1. Thus, HM-MIPs-SPE method proved to be an accuracy and practical platform for detection of estrogens in food samples. ..
  6. Tang X, Li F, Jia J, Yang C, Liu W, Jin B, et al. Synthesis of magnetic molecularly imprinted polymers with excellent biocompatibility for the selective separation and inhibition of testosterone in prostate cancer cells. Int J Nanomedicine. 2017;12:2979-2993 pubmed publisher
    ..Moreover, the MMIPs can freely enter prostate cancer cells and block the activation of testosterone-AR pathway. Thus, the MMIPs may be a new option for antiandrogen therapy in prostate cancer. ..
  7. Ozer E, Osman B, Yazıcı T. Dummy molecularly imprinted microbeads as solid-phase extraction material for selective determination of phthalate esters in water. J Chromatogr A. 2017;1500:53-60 pubmed publisher
    ..Validation experiments showed that the PEMATrp DMIMs-SPE method had good linearity at 12.5-250.0?g/L (0.988-0.999), good precision (1.2-5.9%), and limits of detection in a range of 0.31-0.41?g/L. ..
  8. Shi S, Fan D, Xiang H, Li H. Effective synthesis of magnetic porous molecularly imprinted polymers for efficient and selective extraction of cinnamic acid from apple juices. Food Chem. 2017;237:198-204 pubmed publisher
    ..9995. Finally, the contents of CMA in two kinds of apple juices were determined as 0.132 and 0.120?g/mL. Results indicated the superiority of MPMIPs in the selective extraction field. ..
  9. Xing R, Wang S, Bie Z, He H, Liu Z. Preparation of molecularly imprinted polymers specific to glycoproteins, glycans and monosaccharides via boronate affinity controllable-oriented surface imprinting. Nat Protoc. 2017;12:964-987 pubmed publisher
    ..The entire protocol, including preparation, property characterization and performance evaluation, takes ?3-8 d, depending on the type of substrate and template used. ..
  10. Boulanouar S, Combes A, Mezzache S, Pichon V. Synthesis and application of molecularly imprinted polymers for the selective extraction of organophosphorus pesticides from vegetable oils. J Chromatogr A. 2017;1513:59-68 pubmed publisher
    ..The calculated LOQs (between 0.3 and 2?g/kg) in almond seeds with a SD between 0.1 and 0.4?g/kg were lower than the Maximum Residue Levels (MRLs) established for the corresponding compounds in almond seed. ..
  11. Wang G, Zhang L, Song Y, Liu J, Wang J. Application of molecularly imprinted polymer based matrix solid phase dispersion for determination of fluoroquinolones, tetracyclines and sulfonamides in meat. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1065-1066:104-111 pubmed publisher
    ..5%-102.7%. Therefore, this method could be used as a rapid, simple, specific and sensitive method for multi-determination of the residues of the three classes of drugs in meat. ..
  12. Zhao F, Wang S, She Y, Zhang C, Zheng L, Jin M, et al. Subcritical water extraction combined with molecular imprinting technology for sample preparation in the detection of triazine herbicides. J Chromatogr A. 2017;1515:17-22 pubmed publisher
    ..7-9.8%), and low enough detection limits (0.4-3.3?gkg-1). This combination of SWE and MIP technology is a simple, effective and promising method to selectively extract class-specific compounds in complex samples. ..
  13. Dahaghin Z, Mousavi H, Sajjadi S. A novel magnetic ion imprinted polymer as a selective magnetic solid phase for separation of trace lead(II) ions from agricultural products, and optimization using a Box-Behnken design. Food Chem. 2017;237:275-281 pubmed publisher
  14. Subramani C, Cengiz N, Saha K, Gevrek T, Yu X, Jeong Y, et al. Direct fabrication of functional and biofunctional nanostructures through reactive imprinting. Adv Mater. 2011;23:3165-9 pubmed publisher
  15. Song Y, Li N, Zhang H, Wang G, Liu J, Liu J, et al. Dummy template molecularly imprinted polymer for solid phase extraction of phenothiazines in meat based on computational simulation. Food Chem. 2017;233:422-428 pubmed publisher
    ..0-10ng/g, and the recoveries from the fortified blank samples were in the range of 70.3-96.1%. This is the first study reporting the use of molecularly imprinted polymer-based method for determination of phenothiazines residues in foods. ..
  16. Ji W, Wang T, Liu W, Liu F, Guo L, Geng Y, et al. Water-compatible micron-sized monodisperse molecularly imprinted beads for selective extraction of five iridoid glycosides from Cornus officinalis fructus. J Chromatogr A. 2017;1504:1-8 pubmed publisher
  17. Amsden J, Domachuk P, Gopinath A, White R, Negro L, Kaplan D, et al. Rapid nanoimprinting of silk fibroin films for biophotonic applications. Adv Mater. 2010;22:1746-9 pubmed publisher
  18. Peng D, Li Z, Wang Y, Liu Z, Sheng F, Yuan Z. Enzyme-linked immunoassay based on imprinted microspheres for the detection of sulfamethazine residue. J Chromatogr A. 2017;1506:9-17 pubmed publisher
    ..After the microspheres were coated in microtiter plate wells, the molecular imprinting ELISA (MI-ELISA) method was established based on the direct competition between free SM2 and ..
  19. Matos Cordeiro Borges M, Leijoto de Oliveira H, Bastos Borges K. Molecularly imprinted solid-phase extraction coupled with LC-APCI-MS-MS for the selective determination of serum cholesterol. Electrophoresis. 2017;38:2150-2159 pubmed publisher
    ..46% to 11.54%). The organic MIP showed superior performance compared with the hybrid. Finally, the MISPE procedure followed by LC-APCI-MS-MS analysis showed their suitable applicability to examine CHO and LATHO in serum samples. ..
  20. Sun G, Liu Y, Ahat H, Shen A, Liang X, Xue X, et al. "Two-dimensional" molecularly imprinted solid-phase extraction coupled with crystallization and high performance liquid chromatography for fast semi-preparative purification of tannins from pomegranate husk extract. J Chromatogr A. 2017;1505:35-42 pubmed publisher
    ..8%. All above indicated that 2D-MIP-SPE was highly efficient in natural product purification. The concept of "functional complementation" was expected to be a useful tool in the construction of 2D-MIP-SPE. ..
  21. El Beqqali A, Andersson L, Jeppsson A, Abdel Rehim M. Molecularly imprinted polymer-sol-gel tablet toward micro-solid phase extraction: II. Determination of amphetamine in human urine samples by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1063:130-135 pubmed publisher
    ..0-104.0% and inter-assay precision was 4.8-8.5% (RSD). Extraction recovery was 80%. The MIP-tablets could be re-used and the same tablet could be employed for more than twenty extractions. ..
  22. Zhao F, She Y, Zhang C, Cao X, Wang S, Zheng L, et al. Selective solid-phase extraction based on molecularly imprinted technology for the simultaneous determination of 20 triazole pesticides in cucumber samples using high-performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1064:143-150 pubmed publisher
    ..3% to 117.6% with relative standard deviations of less than 11.8% (n=5) for all analytes. The limits of detection for the 20 triazole pesticides were all less than 0.4?gL-1, and were sufficient to meet international standards. ..
  23. Li M, Wang X, Zhang L, Wei X. A high sensitive epitope imprinted electrochemical sensor for bovine serum albumin based on enzyme amplifying. Anal Biochem. 2017;530:68-74 pubmed publisher
    To improve the sensitivity of the molecular imprinting sensor detection of protein, a new strategy based on enzyme amplification was proposed...
  24. He X, Chen J, Wang J, Tan L. Multipoint recognition of domoic acid from seawater by dummy template molecularly imprinted solid-phase extraction coupled with high-performance liquid chromatography. J Chromatogr A. 2017;1500:61-68 pubmed publisher
    ..This new polymer can be effectively applied to the monitoring and predicting the existence of trace DA. ..