vanadates

Summary

Summary: Oxyvanadium ions in various states of oxidation. They act primarily as ion transport inhibitors due to their inhibition of Na(+)-, K(+)-, and Ca(+)-ATPase transport systems. They also have insulin-like action, positive inotropic action on cardiac ventricular muscle, and other metabolic effects.

Top Publications

  1. Clark T, Heyliger C, Kopilas M, Edel A, Junaid A, Aguilar F, et al. A tea/vanadate decoction delivered orally over 14 months to diabetic rats induces long-term glycemic stability without organ toxicity. Metabolism. 2012;61:742-53 pubmed publisher
    ..Oral administration of a T/V decoction provides safe, long-acting hypoglycemic effects in type 1 diabetes mellitus rats. The typical glycemic signs of diabetes were absent for the last 5 months of the study...
  2. Gaveglio V, Pasquaré S, Giusto N. Metabolic pathways for the degradation of phosphatidic acid in isolated nuclei from cerebellar cells. Arch Biochem Biophys. 2011;507:271-80 pubmed publisher
    ..Our findings constitute the first reported evidence of active PtdOH metabolism involving LPP, DAGL and PtdOH-selective PLA activities in purified nuclei prepared from cerebellar cells...
  3. Thompson K, Lichter J, LeBel C, Scaife M, McNeill J, Orvig C. Vanadium treatment of type 2 diabetes: a view to the future. J Inorg Biochem. 2009;103:554-8 pubmed publisher
  4. Villalba N, Kun A, Stankevicius E, Simonsen U. Role for tyrosine kinases in contraction of rat penile small arteries. J Sex Med. 2010;7:2086-2095 pubmed publisher
    ..However, tyrosine kinases are not only important for cell growth and proliferation, but also in regulation of vascular tone...
  5. Holtz R, Souza Filho A, Brocchi M, Martins D, Duran N, Alves O. Development of nanostructured silver vanadates decorated with silver nanoparticles as a novel antibacterial agent. Nanotechnology. 2010;21:185102 pubmed publisher
    ..The influence of the pH of the reaction medium on the chemical structure and morphology of silver vanadates was studied and we found that synthesis performed at pH 5.5-6...
  6. Sharma S, Singh M, Sharma P. Mechanism of attenuation of diabetes mellitus and hypercholesterolemia induced vascular endothelial dysfunction by protein tyrosine phosphatase inhibition. Vascul Pharmacol. 2011;54:80-7 pubmed publisher
    ..Thus, inhibition of PTPase might be a useful approach in the therapeutics of vascular endothelium dysfunction...
  7. Zhao L, Wang Z, Ruan Y, Zhou W. Cellular mechanism underlying the facilitation of contractile response of vas deferens smooth muscle by sodium orthovanadate. Mol Cell Biochem. 2012;366:149-57 pubmed publisher
  8. Cui W, Cui H, Peng X, Fang J, Zuo Z, Liu X, et al. Dietary vanadium induces lymphocyte apoptosis in the bursa of Fabricius of broilers. Biol Trace Elem Res. 2012;146:59-67 pubmed publisher
    ..Lymphocyte apoptosis in the bursa induced by high levels of dietary vanadium is associated with mitochondrial injury and changes in levels of apoptogenic proteins, such as Bcl-2, Bax, and caspase-3...
  9. Morita A, Yamamoto S, Wang B, Tanaka K, Suzuki N, Aoki S, et al. Sodium orthovanadate inhibits p53-mediated apoptosis. Cancer Res. 2010;70:257-65 pubmed publisher

Scientific Experts

More Information

Publications62

  1. Laizé V, Tiago D, Aureliano M, Cancela M. New insights into mineralogenic effects of vanadate. Cell Mol Life Sci. 2009;66:3831-6 pubmed publisher
  2. Grasa L, Arruebo M, Plaza M, Murillo M. The role of tyrosine kinase in prostaglandin E2 and vanadate-evoked contractions in rabbit duodenum in vitro. J Physiol Pharmacol. 2006;57:279-89 pubmed
    ..Protein tyrosine phosphorylation might cause an increase in calcium influx through voltage-dependent channels and the release of prostaglandins in the longitudinal smooth muscle of the rabbit duodenum...
  3. Radha V, Rajanna A, Swarup G. Phosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton. BMC Cell Biol. 2004;5:31 pubmed
    ..C3G is activated upon phosphorylation at tyrosine 504 and therefore, determining the localization of phosphorylated C3G would provide an insight into its site of action in the cellular context...
  4. Winter C, Lange J, Davis M, Gerwe G, Downs T, Peters K, et al. A nonspecific phosphotyrosine phosphatase inhibitor, bis(maltolato)oxovanadium(IV), improves glucose tolerance and prevents diabetes in Zucker diabetic fatty rats. Exp Biol Med (Maywood). 2005;230:207-16 pubmed
    ..These data demonstrate that phosphatase inhibition offers a new approach to diabetes prevention, one that may have advantages over current approaches...
  5. Yu J, Mizumoto K, Kakutani T, Hasegawa A, Ogawa K, Hatano Y. Comparison of the effects of isoflurane and sevoflurane on protein tyrosine phosphorylation-mediated vascular contraction. Acta Anaesthesiol Scand. 2005;49:852-8 pubmed
  6. Davies D, Mushtaq A, Interthal H, Champoux J, Hol W. The structure of the transition state of the heterodimeric topoisomerase I of Leishmania donovani as a vanadate complex with nicked DNA. J Mol Biol. 2006;357:1202-10 pubmed
    ..This structure fills a critical gap in the existing ensemble of topoisomerase I structures and provides crucial insights into the catalytic mechanism...
  7. Feng J, Park J, Cron P, Hess D, Hemmings B. Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J Biol Chem. 2004;279:41189-96 pubmed
    ..We conclude that DNA-PK is a long sought after kinase responsible for the Ser-473 phosphorylation step in the activation of PKB...
  8. Gerling N, Culmsee C, Klumpp S, Krieglstein J. The tyrosine phosphatase inhibitor orthovanadate mimics NGF-induced neuroprotective signaling in rat hippocampal neurons. Neurochem Int. 2004;44:505-20 pubmed
    ..Thus, PTP inhibition appears to be an appropriate strategy to trigger neuroprotective signaling pathways downstream of neurotrophin receptors...
  9. Carr A, Davis M, Eby Wilkens E, Howard B, Towne B, Dufresne T, et al. Tyrosine phosphatase inhibition augments collateral blood flow in a rat model of peripheral vascular disease. Am J Physiol Heart Circ Physiol. 2004;287:H268-76 pubmed
  10. Takahashi H, Suzuki K, Namiki H. Pervanadate-induced reverse translocation and tyrosine phosphorylation of phorbol ester-stimulated protein kinase C betaII are mediated by Src-family tyrosine kinases in porcine neutrophils. Biochem Biophys Res Commun. 2004;314:830-7 pubmed
    ..Our findings provide novel insight into the relationship between the subcellular localization and tyrosine phosphorylation of PKC...
  11. Tiago D, Laizé V, Cancela M, Aureliano M. Impairment of mineralization by metavanadate and decavanadate solutions in a fish bone-derived cell line. Cell Biol Toxicol. 2008;24:253-63 pubmed
    ..Newly developed VSa13 fish cells appeared to be appropriate in the characterization of vanadate effects on vertebrate bone formation, representing a good alternative to mammalian systems...
  12. Milward A, Riba R, Patel B, Oberprieler N, Naseem K. Sodium orthovanadate induced tyrosine phosphorylation of platelet nitric oxide synthase negatively regulates enzyme activity. Biochim Biophys Acta. 2006;1760:1411-7 pubmed
    ..Our data indicate that tyrosine phosphorylation may act to repress NOS activity. Furthermore, VO4 induces a Src-dependent, and to a lesser degree PKC-dependent, inhibition of platelet NOS...
  13. Morita A, Zhu J, Suzuki N, Enomoto A, Matsumoto Y, Tomita M, et al. Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53. Cell Death Differ. 2006;13:499-511 pubmed
    ..Vanadate is conventionally used as an inhibitor of protein tyrosine phosphatases (PTPs); however, we recommend that the influence of vanadate not only on PTPs but also on p53 be considered before using it...
  14. Tao G, Zhou Q, Strnad P, Salemi M, Lee Y, Omary M. Human Ran cysteine 112 oxidation by pervanadate regulates its binding to keratins. J Biol Chem. 2005;280:12162-7 pubmed
    ..In cells, stabilization of oxidized Ran by proteasome inhibition promotes Ran-keratin interaction. Keratin sequestration of oxidized Ran may provide a back-up protective mechanism in some cases of oxidative injury...
  15. Poustka F, Irani N, Feller A, Lu Y, Pourcel L, Frame K, et al. A trafficking pathway for anthocyanins overlaps with the endoplasmic reticulum-to-vacuole protein-sorting route in Arabidopsis and contributes to the formation of vacuolar inclusions. Plant Physiol. 2007;145:1323-35 pubmed
    ..Taken together, these results provide evidence for an alternative novel mechanism of vesicular transport and vacuolar sequestration of anthocyanins in Arabidopsis...
  16. Ting C, Lin C, Wen S, Hsieh Li H, Li H. Stat5 constitutive activation rescues defects in spinal muscular atrophy. Hum Mol Genet. 2007;16:499-514 pubmed
    ..These results demonstrate that Stat5 signaling could be a possible pharmacological target for treating SMA...
  17. Kafl H, Elkashef H. Effect of sodium orthovanadate on the urinary bladder rings isolated from normal and hyperglycemic rats. Pak J Pharm Sci. 2006;19:195-201 pubmed
    ..The present results suggested a key role of H(2)O(2) in mediating the contraction of urinary bladder rings induced by vanadate...
  18. Shah D, Singh M. Inhibition of protein tyrosin phosphatase improves vascular endothelial dysfunction. Vascul Pharmacol. 2006;44:177-82 pubmed
    ..Therefore, it may be concluded that BMOV induced inhibition of PTPase may activate eNOS due to opening of ATP sensitive K(+) channels and consequently reduce oxidative stress to improve vascular endothelial dysfunction...
  19. Edel A, Kopilas M, Clark T, Aguilar F, Ganguly P, Heyliger C, et al. Short-term bioaccumulation of vanadium when ingested with a tea decoction in streptozotocin-induced diabetic rats. Metabolism. 2006;55:263-70 pubmed
    ..However, this effect is unlikely to be of a magnitude to explain the full capacity of TV to reduce the toxic side effects of vanadate...
  20. Sugano M, Tsuchida K, Makino N. A protein tyrosine phosphatase inhibitor accelerates angiogenesis in a rat model of hindlimb ischemia. J Cardiovasc Pharmacol. 2004;44:460-5 pubmed
    ..SOV activated KDR/flk-1 and accelerated angiogenesis. Thus, a PTP inhibitor can be a new drug for therapeutic angiogenesis in peripheral ischemic diseases...
  21. Tiago D, Cancela M, Aureliano M, Laizé V. Vanadate proliferative and anti-mineralogenic effects are mediated by MAPK and PI-3K/Ras/Erk pathways in a fish chondrocyte cell line. FEBS Lett. 2008;582:1381-5 pubmed publisher
    ..Finally, this work provides additional evidence for the conservation, throughout evolution, of mechanisms regulating chondrocyte proliferation and differentiation...
  22. Sun Y, Zheng Y, Lei W, Zhou Q, Hou Y, Zhang B, et al. Oxovanadium(IV) based hypocrellin B complexes with enhanced photodynamic activity. Dalton Trans. 2012;41:651-7 pubmed publisher
    ..Our work opens a new avenue for the development of HB-based PDT agents...
  23. Luo W, Wang J, Zhao X, Zhao Z, Li Z, Zou Z. Formation energy and photoelectrochemical properties of BiVO4 after doping at Bi3+ or V5+ sites with higher valence metal ions. Phys Chem Chem Phys. 2013;15:1006-13 pubmed publisher
    ..The higher formation energy of Sn(4+) came from the large mismatch of ion radius and different outer shell electron distribution. These results can offer guidance in choosing suitable doping ions for other semiconductor photoelectrodes...
  24. Choi S, Choi W, Park H. Solar water oxidation using nickel-borate coupled BiVO4 photoelectrodes. Phys Chem Chem Phys. 2013;15:6499-507 pubmed publisher
    ..Under identical PEC conditions (0.1 M, pH 9.2), the borate electrolyte (good proton acceptor) is found to be better than nitrate (poor proton acceptor), indicative of a proton-coupled electron transfer pathway in PEC water oxidation...
  25. O Donnell R, Pearson D, McKnight H, Ma Y, Tuscano J. Treatment of non-Hodgkin's lymphoma xenografts with the HB22.7 anti-CD22 monoclonal antibody and phosphatase inhibitors improves efficacy. Cancer Immunol Immunother. 2009;58:1715-22 pubmed publisher
    ..To examine the role of phosphatase inhibition on anti-CD22, HB22.7-mediated lymphomacidal effects...
  26. Bobyr E, LASSILA J, Wiersma Koch H, Fenn T, Lee J, Nikolic Hughes I, et al. High-resolution analysis of Zn(2+) coordination in the alkaline phosphatase superfamily by EXAFS and x-ray crystallography. J Mol Biol. 2012;415:102-17 pubmed publisher
    ..Overall, the results suggest that the binuclear Zn(2+) catalytic site remains very similar between AP and NPP during the course of a reaction cycle...
  27. Cheng Z, Ma P, Hou Z, Wang W, Dai Y, Zhai X, et al. YVO4:Eu3+ functionalized porous silica submicrospheres as delivery carriers of doxorubicin. Dalton Trans. 2012;41:1481-9 pubmed publisher
    ..These results suggest that the composite can potentially act as a multifunctional drug carrier system with luminescent tagging and pH-controlled release properties...
  28. Badone F, Cassani E, Landoni M, Doria E, Panzeri D, Lago C, et al. The low phytic acid1-241 (lpa1-241) maize mutation alters the accumulation of anthocyanin pigment in the kernel. Planta. 2010;231:1189-99 pubmed publisher
    ..On the whole, these data strongly suggest a possible interaction between the lpa mutation and anthocyanin accumulation and compartmentalisation in the kernel...
  29. Tiago D, Cancela M, Laizé V. Proliferative and mineralogenic effects of insulin, IGF-1, and vanadate in fish osteoblast-like cells. J Bone Miner Metab. 2011;29:377-82 pubmed publisher
    ..The comparison of these new data obtained in fish with those available in mammals clearly evidenced a conservation of regulatory mechanisms among vertebrate bone-derived systems, although different players are involved...
  30. Sanna D, Buglyo P, Micera G, Garribba E. A quantitative study of the biotransformation of insulin-enhancing VO(2+) compounds. J Biol Inorg Chem. 2010;15:825-39 pubmed publisher
    ..in Inorg. Chem. 49:174-187, 2010) and to predict the distribution of VO(2+) ion in blood serum when one of the four insulin-enhancing vanadium compounds studied, [VO(carrier)(2)], is administered...
  31. Simoneau M, Coulombe G, Vandal G, Vezina A, Rivard N. SHP-1 inhibits ?-catenin function by inducing its degradation and interfering with its association with TATA-binding protein. Cell Signal. 2011;23:269-79 pubmed publisher
  32. Haldar A, Banerjee S, Naskar K, Kalita D, Islam N, Roy S. Sub-optimal dose of Sodium Antimony Gluconate (SAG)-diperoxovanadate combination clears organ parasites from BALB/c mice infected with antimony resistant Leishmania donovani by expanding antileishmanial T-cell repertoire and increasing IFN-gamma t. Exp Parasitol. 2009;122:145-54 pubmed
    ..Our study indicates that the combination of sub-optimal doses of SAG and PV6 may be beneficial for the treatment of SAG resistant visceral leishmaniasis patients...
  33. Shimizu Y, Obora Y, Ishii Y. Intermolecular aerobic oxidative allylic amination of simple alkenes with diarylamines catalyzed by the Pd(OCOCF3)2/NPMoV/O2 system. Org Lett. 2010;12:1372-4 pubmed publisher
  34. Ross A, Soares D, Covelli D, Pannecouque C, Budd L, Collins A, et al. Oxovanadium(IV) cyclam and bicyclam complexes: potential CXCR4 receptor antagonists. Inorg Chem. 2010;49:1122-32 pubmed publisher
    ..In addition, hydrophobic interactions with Trp195 are present. Both ring configuration and the xylyl linker may play roles in determining the higher activity of the bicyclam complexes...
  35. Olopade J, Fatola I, Olopade F. Vertical administration of vanadium through lactation induces behavioural and neuromorphological changes: protective role of vitamin E. Niger J Physiol Sci. 2011;26:55-60 pubmed
  36. Firaguay G, Nunes J. Analysis of signaling events by dynamic phosphoflow cytometry. Sci Signal. 2009;2:pl3 pubmed publisher
    ..This dynamic approach, in combination with the signal amplification through a sandwich-labeling method, produces accurate and reproducible measurement of the activity of signaling pathways...
  37. Chohan Z, Sumrra S. Synthesis, characterization and biological properties of thienyl derived triazole Schiff bases and their oxovanadium(IV) complexes. J Enzyme Inhib Med Chem. 2012;27:187-93 pubmed publisher
    ..Brine shrimp bioassay was also carried out to check the cytotoxic nature of these compounds...
  38. Zhao Z, Dai H, Deng J, Liu Y, Wang Y, Li X, et al. Porous FeOx/BiVO4-deltaS0.08: highly efficient photocatalysts for the degradation of methylene blue under visible-light illumination. J Environ Sci (China). 2013;25:2138-49 pubmed
    ..We believe that the sulfur and FeOx co-doping, higher oxygen adspecies concentration, and lower bandgap energy were responsible for the excellent visible-light-driven catalytic activity of 1.40 wt.% FeOx/BiVO4-deltaS0.08...
  39. Ramos S, Moura J, Aureliano M. Recent advances into vanadyl, vanadate and decavanadate interactions with actin. Metallomics. 2012;4:16-22 pubmed publisher
    ..By affecting actin structure and function, vanadium can regulate many cellular processes of great physiological significance...
  40. Agarwal A, Sheoran A, Sanghi S, Bhatnagar V, Gupta S, Arora M. Structural investigation and electron paramagnetic resonance of vanadyl doped alkali niobium borate glasses. Spectrochim Acta A Mol Biomol Spectrosc. 2010;75:964-9 pubmed publisher
    ..The 3d(xy) orbit contracts with increase in Nb(2)O(5):M(2)O ratio. Values of the theoretical optical basicity, Lambda(th), have also been reported...
  41. Cho S. Synthesis and luminescence properties of LaVO4:RE3+ (RE = Sm, Eu, Tb, Tm) phosphors. J Nanosci Nanotechnol. 2013;13:7546-50 pubmed
    ..These results suggest that the multicolor emissions can be realized by controlling activator ions incorporated into host crystals...
  42. Imura H, Shimada A, Naota M, Morita T, Togawa M, Hasegawa T, et al. Vanadium toxicity in mice: possible impairment of lipid metabolism and mucosal epithelial cell necrosis in the small intestine. Toxicol Pathol. 2013;41:842-56 pubmed publisher
    ..In conclusion, AMV may impair cellular lipid metabolism, resulting in lipid accumulation, and induce mucosal epithelial cell necrosis in the small intestine. ..
  43. Sánchez González C, Bermudez Peña C, Guerrero Romero F, Trenzado C, Montes Bayon M, Sanz Medel A, et al. Effect of bis(maltolato)oxovanadium (IV) (BMOV) on selenium nutritional status in diabetic streptozotocin rats. Br J Nutr. 2012;108:893-9 pubmed publisher
    ..We conclude that under the experimental conditions described, the treatment with 3 mg V/d caused a tissue depletion of Se that compromised Se nutritional status and antioxidant defences in the tissues...
  44. Suwalsky M, Fierro P, Villena F, Gallardo M, Jemiola Rzeminska M, Strzalka K, et al. Effects of sodium metavanadate on in vitro neuroblastoma and red blood cells. Arch Biochem Biophys. 2013;535:248-56 pubmed publisher
    ..Also, partly unsaturated lipids could interact differently the fully saturated chains in the model systems...
  45. Liu S, Hu F, Zhang J, Tang H, Shao M. Surface-doping effect of InVO4 nanoribbons and the distinctive behavior as gas sensors. ACS Appl Mater Interfaces. 2013;5:3208-11 pubmed publisher
    ..They also had great response to a wide range of target gas concentration, with ultrahigh sensitivities up to 1100% for ammonia and 760% for propylamine...
  46. Banerjee S, Prasad P, Hussain A, Khan I, Kondaiah P, Chakravarty A. Remarkable photocytotoxicity of curcumin in HeLa cells in visible light and arresting its degradation on oxovanadium(IV) complex formation. Chem Commun (Camb). 2012;48:7702-4 pubmed publisher
    ..2 ± 0.2 ?M and its degradation is arrested on formation of photocytotoxic dipyridophenazine (dppz) complex [VO(cur)(dppz)Cl] (IC(50) = 3.3 ± 0.4 ?M), while both are less toxic in the dark...
  47. Kasinathan R, Goronga T, Messerli S, Webb T, Greenberg R. Modulation of a Schistosoma mansoni multidrug transporter by the antischistosomal drug praziquantel. FASEB J. 2010;24:128-35 pubmed publisher
    ..The interaction of praziquantel with SMDR2 may offer new strategies for potentiating the action of praziquantel and possibly overcoming drug resistance...
  48. Hasegawa Y, Suzuki H, Altay O, Zhang J. Preservation of tropomyosin-related kinase B (TrkB) signaling by sodium orthovanadate attenuates early brain injury after subarachnoid hemorrhage in rats. Stroke. 2011;42:477-83 pubmed publisher
    ..We also administered K252a, a tropomyosin-related kinase B antagonist, to examine the mechanisms for neuroprotective effects by SOV...
  49. Kar R, Parvin N, Laha D. Differential role of ethylene and hydrogen peroxide in dark-induced stomatal closure. Pak J Biol Sci. 2013;16:1991-6 pubmed
    ..A combination of LaCl3 and propyl gallate strongly promoted stomatal opening. A probable action of ethylene in closing stomata of Commelina benghalensis in dark has been proposed...
  50. Rowe C, Heyes A, Hilton J. Differential patterns of accumulation and depuration of dietary selenium and vanadium during metamorphosis in the Gray Treefrog (Hyla versicolor). Arch Environ Contam Toxicol. 2011;60:336-42 pubmed publisher
  51. Pereira M, Carvalho E, Eriksson J, Crans D, Aureliano M. Effects of decavanadate and insulin enhancing vanadium compounds on glucose uptake in isolated rat adipocytes. J Inorg Biochem. 2009;103:1687-92 pubmed publisher
    ..Altogether, vanadium compounds and oligovanadates with several structures and coordination spheres reveal different effects on glucose uptake in rat primary adipocytes...
  52. Obianime A, Gogo Abite M, Roberts I. The effects of ammonium metavanadate on biochemical, hormonal, haematological and histopathological parameters of the female Wistar rats. Niger J Physiol Sci. 2009;24:187-94 pubmed
    ..These were characterized by necrosis, oedema, eosinophilic deposits and vacuolation. These results may be explained by the oxidative effects caused by the free oxygen [O2] radical generated by the metavanadate ions...
  53. Chatterjee N, Kiran S, Ram B, Islam N, Ramasarma T, Ramakrishna G. Diperoxovanadate can substitute for H(2)O(2) at much lower concentration in inducing features of premature cellular senescence in mouse fibroblasts (NIH3T3). Mech Ageing Dev. 2011;132:230-9 pubmed publisher
    ..DPV-treated cells showed marked relocalization of Cyclin D1 from nucleus to cytoplasm. These results indicate that DPV, stable inorganic peroxide, is more efficient in inducing SIPS at lower concentrations compared to H(2)O(2)...