sodium pertechnetate tc 99m

Summary

Summary: A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, cardiovascular and cerebral circulation, brain, thyroid, and joints.

Top Publications

  1. Siddiqui F, Barton K, Stricker H, Steyn P, LaRue S, Karvelis K, et al. Design considerations for incorporating sodium iodide symporter reporter gene imaging into prostate cancer gene therapy trials. Hum Gene Ther. 2007;18:312-22 pubmed
  2. Schipper M, Riese C, Seitz S, Weber A, Behe M, Schurrat T, et al. Efficacy of 99mTc pertechnetate and 131I radioisotope therapy in sodium/iodide symporter (NIS)-expressing neuroendocrine tumors in vivo. Eur J Nucl Med Mol Imaging. 2007;34:638-650 pubmed publisher
    ..Here, we show the feasibility of radioisotope therapy of neuroendocrine tumors. As a separate application of NIS gene transfer, we image NIS-expressing tumors with pinhole SPECT in living subjects...
  3. Rebello B, Moreno S, Godinho C, Neves R, Fonseca A, Bernardo Filho M, et al. Effects of Passiflora edulis flavicarpa on the radiolabeling of blood constituents, morphology of red blood cells and on the biodistribution of sodium pertechnetate in rats. Appl Radiat Isot. 2008;66:1788-92 pubmed publisher
    ..flavicarpa extract. Although our results were obtained with animals, they could contribute to reduce the risk of misdiagnosis and/or repetition of the examinations in nuclear medicine...
  4. Zuckier L, Dohan O, Li Y, Chang C, Carrasco N, Dadachova E, et al. Kinetics of perrhenate uptake and comparative biodistribution of perrhenate, pertechnetate, and iodide by NaI symporter-expressing tissues in vivo. J Nucl Med. 2004;45:500-7 pubmed
    ..In this study, we endeavored to characterize the biologic behavior of perrhenate, especially in relation to iodide and pertechnetate, to better explore its possible therapeutic role...
  5. Chen L, Altman A, Mier W, Lu H, Zhu R, Haberkorn U. 99mTc-pertechnetate uptake in hepatoma cells due to tissue-specific human sodium iodide symporter gene expression. Nucl Med Biol. 2006;33:575-80 pubmed
    ..Herein, we investigated the feasibility of monitoring human sodium iodide symporter (hNIS) gene expression with 99mTc-pertechnetate in hepatoma cells (MH3924A) following tissue-specific expression...
  6. Terrovitis J, Kwok K, Lautamaki R, Engles J, Barth A, Kizana E, et al. Ectopic expression of the sodium-iodide symporter enables imaging of transplanted cardiac stem cells in vivo by single-photon emission computed tomography or positron emission tomography. J Am Coll Cardiol. 2008;52:1652-60 pubmed publisher
  7. Rêgo A, Ramalho R, Egito E, Araujo Filho I, Azevedo I, Palestro C, et al. Biodistribution of technetium-99m pertechnetate after total colectomy in rats. Appl Radiat Isot. 2010;68:2169-73 pubmed publisher
    ..05). Increase in mucosa and muscularis size of ileum was observed. Colectomy was associated with lower biodistribution in bladder and thyroid, T3, and T4, than in controls...
  8. Phom H, Kumar A, Tripathi M, Chandrashekar N, Choudhry V, Malhotra A, et al. Comparative evaluation of Tc-99m-heat-denatured RBC and Tc-99m-anti-D IgG opsonized RBC spleen planar and SPECT scintigraphy in the detection of accessory spleen in postsplenectomy patients with chronic idiopathic thrombocytopenic purpura. Clin Nucl Med. 2004;29:403-9 pubmed
    ..We compared the efficacy of RIS with HDRBC for the detection of accessory spleens..
  9. Capriles P, Dias A, Costa T, Oliveira M, Faria M, Moura E, et al. Effect of eggplant (Solanum melongena) extract on the in vitro labeling of blood elements with technetium-99m and on the biodistribution of sodium pertechnetate in rats. Cell Mol Biol (Noisy-le-grand). 2002;48:771-6 pubmed
    ..Moreover, as eggplant is metabolized in the liver, this fact could justify the alteration of the uptake in this organ...

More Information

Publications62

  1. Campenni A, Ruggeri R, Santoro D, Cucinotta M, Conti S, Sindoni A, et al. Accidental discovery of lung metastases from differentiated thyroid cancer by 99mTc sodium pertechnetate scan in a patient with secondary hyperparathyroidism. Clin Nucl Med. 2012;37:895-6 pubmed publisher
    ..Neck ultrasonographynography was negative. The patient underwent I therapy (3700 MBq) after stimulation with recombinant human thyroid-stimulating hormone. Postdose whole-body scan confirmed the metastases already demonstrated by TcO4...
  2. Leibovitch I, Hoyama E, Limawararut V, Crompton J, Selva D. Novel technique to control hypersecretion from a transplanted autologous submandibular salivary gland for keratoconjunctivitis sicca. Cornea. 2006;25:1251-3 pubmed
    ..To present a novel technique to control hypersecretion from a transplanted autologous submandibular gland (SMG) in a patient with keratoconjunctivitis sicca...
  3. Ballani N, Dougherty G. The effect of finite spatial resolution on the measurement of cardiac phantom wall thickness in single photon emission computerized tomographic imaging. Med Princ Pract. 2004;13:316-24 pubmed
    ..To devise and validate a method of estimating accurately myocardial wall thickness from cardiac images acquired with single photon emission tomography (SPECT)...
  4. Olds G, Cooper G, Chak A, Sivak M, Chitale A, Wong R. The yield of bleeding scans in acute lower gastrointestinal hemorrhage. J Clin Gastroenterol. 2005;39:273-7 pubmed
    ..Our objective was to evaluate the accuracy of TRBC scintigraphy in clinical day-to-day practice at our institution and to determine predictors of a positive test...
  5. Kim T, Ryu Y, Hur J, Kim S, Kim H, Choi B, et al. Evaluation of right ventricular volume and mass using retrospective ECG-gated cardiac multidetector computed tomography: comparison with first-pass radionuclide angiography. Eur Radiol. 2005;15:1987-93 pubmed
    ..8% for the RVESV, and 7.9% for the RV mass, respectively. Cardiac MDCT is relatively simple and allows the RV volume and mass to be assessed, and the RVEF obtained by cardiac MDCT correlates well with that measured by FPRA...
  6. Kumar R, Tripathi M, Chandrashekar N, Agarwala S, Kumar A, Dasan J, et al. Diagnosis of ectopic gastric mucosa using 99Tcm-pertechnetate: spectrum of scintigraphic findings. Br J Radiol. 2005;78:714-20 pubmed
    ..In conclusion, a variety of scintigraphic patterns may be found in patients with ectopic gastric mucosa undergoing (99)Tc(m)-pertechnetate scintigraphy depending upon the location and size of the ectopic tissue...
  7. Kairinos N, Voogd A, Botha P, Kotze T, Kahn D, Hudson D, et al. Negative-pressure wound therapy II: negative-pressure wound therapy and increased perfusion. Just an illusion?. Plast Reconstr Surg. 2009;123:601-12 pubmed publisher
    ..This study investigated perfusion in negative-pressure wound therapy using two alternative modalities...
  8. Fard Esfahani A, Gholamrezanezhad A, Mirpour S, Tari A, Saghari M, Beiki D, et al. Assessment of the accuracy of lacrimal scintigraphy based on a prospective analysis of patients' symptomatology. Orbit. 2008;27:237-41 pubmed publisher
    ..In our hypothesis, follow-up of patients evaluated with dacryoscintigraphy could be helpful in determining possible explanations for these conflicting results...
  9. Cho S, Park H, Kim J, Ryu Y, Lee S, Conklin J. Effect of sildenafil on gastric emptying in healthy adults. J Gastroenterol Hepatol. 2006;21:222-6 pubmed
    ..The aim of this study was to test the hypothesis that sildenafil alters gastric emptying and the intragastric distribution of food in healthy adults...
  10. Koca G, Gültekin S, Han U, Kuru S, Demirel K, Korkmaz M. The efficacy of montelukast as a protective agent against 131I-induced salivary gland damage in rats: scintigraphic and histopathological findings. Nucl Med Commun. 2013;34:507-17 pubmed publisher
    ..This study was designed to evaluate the efficiency of montelukast as a novel radioprotective agent against sodium [131I]iodide or potassium [131I]iodide (131I)-induced salivary gland damage in a rat model...
  11. Ponto J. Salvage of substandard in vitro technetium Tc-99m-labeled red blood cells. J Am Pharm Assoc (2003). 2006;46:401-2 pubmed
  12. Morandi F, Cole R, Echandi R, Daniel G. Transsplenic portal scintigraphy using 99mTc-mebrofenin in normal dogs. Vet Radiol Ultrasound. 2007;48:286-91 pubmed
    ..99mTc-mebrofenin can be used in place of pertechnetate for transsplenic portal scintigraphy, with the advantage of combining quantitative parameters of liver function with the already known advantage of transsplenic portal scintigraphy...
  13. Chawla M, Kumar R, Malhotra A. Dual ectopic thyroid: case series and review of the literature. Clin Nucl Med. 2007;32:1-5 pubmed
    ..We report 4 such cases in which ectopic thyroid tissue was simultaneously present at 2 different locations using thyroid scanning. The literature of already reported cases is reviewed in detail...
  14. Tang Z, Li W. [Diagnosis of ectopic thyroid in the tongue root by 99mTcO4(-) and 131I radionuclide thyroid imaging: report of one case]. Di Yi Jun Yi Da Xue Xue Bao. 2003;23:1041-2 pubmed
  15. Kulkarni M, Shetkar S, Joshi P, Kasaliwal S, Chaudhari S. Incidental Warthin Tumor on Pertechnetate Scintigraphy. Clin Nucl Med. 2016;41:728-9 pubmed publisher
    ..Clinical examination and ultrasonography revealed a well-defined lesion in the superficial lobe of the right parotid gland favoring diagnosis of benign lesion. Postsurgery specimen confirmed diagnosis of Warthin tumor. ..
  16. Rubello D, Gross M. Re: can thallium-pertechnetate subtraction scanning play a role in the preoperative imaging for minimally invasive parathyroidectomy?. Clin Nucl Med. 2007;32:825 pubmed
  17. Li B, Huang X, Zheng C, Zhou J, Zhao Y. Ileal duplication mimicking intestinal intussusception: a congenital condition rarely reported in adult. World J Gastroenterol. 2013;19:6500-4 pubmed publisher
    ..Pathological examination showed ileal duplication with ectopic gastric mucosa. The patient experienced an eventless postoperative recovery and remained asymptomatic within 2 years of postoperative follow-up. ..
  18. Markovic V, Eterovic D, Punda A, Pešutić Pisac V, Kuna T. Preoperative Tc-99m-pertechnetate scan visualization of gross neck metastases from microcarcinoma papillare and another papillary carcinoma of tall cell variant scintigraphically presented like small warm nodule in Graves disease patient. Clin Nucl Med. 2010;35:858-61 pubmed publisher
    ..We present a patient with Graves disease and both of these rare entities...
  19. Sukan A, Bayazit A, Kibar M, Noyan A, Soyupak S, Yapar Z, et al. Comparison of direct radionuclide cystography and voiding direct cystography in the detection of vesicoureteral reflux. Ann Nucl Med. 2003;17:549-53 pubmed
    ..The aim of this study is to compare the results of direct radionuclide cystography (DRNC) and voiding cystourethrography (VCUG) in a group of children with a high suspicion of vesicoureteral reflux (VUR)...
  20. Connolly S, Drubach L, Connolly L. Meckel's diverticulitis: diagnosis with computed tomography and Tc-99m pertechnetate scintigraphy. Clin Nucl Med. 2004;29:823-4 pubmed
  21. Santos Filho S, Bernardo Filho M. [Effect of Hypericum perforatum extract on in vitro labelling of blood elements with technetium-99m and on biodisponibility of sodium pertechnetate in Wistar rats]. Acta Cir Bras. 2005;20 Suppl 1:121-5 pubmed
    ..To evaluate the effect of a hiperico extract (Hypericum perforatum) on the labeling of blood elements with technetium-99m (99mTc) and in the bioavailability of the radiopharmaceutical sodium pertechnetate in Wistar rats...
  22. Mychka V, Chazova I, Gornostaev V, Sergienko V. [Primary prophylaxis of cerebrovascular complications in patients with metabolic syndrome]. Ter Arkh. 2005;77:20-4 pubmed
    ..To study effects of antihypertensive therapy with bisoprolol and actovegin on cerebral perfusion in patients with metabolic syndrome...
  23. Henrikson T, Armbrust L, Hoskinson J, Milliken G, Wedekind K, Kirk C, et al. Thyroid to salivary ratios determined by technetium-99m pertechnetate imaging in thirty-two euthyroid cats. Vet Radiol Ultrasound. 2005;46:521-3 pubmed
    ..48-1.66. This range is similar to previous studies, but suggests a slightly higher upper limit than previously reported...
  24. Kim I, Choo K, Lee J, Kim S, Kim J, Kim Y, et al. Comparison of gated blood pool SPECT and multi-detector row computed tomography for measurements of left ventricular volumes and ejection fraction in patients with atypical chest pain: validation with radionuclide ventriculography. Cardiology. 2007;107:8-16 pubmed
  25. Buchmann I, Riedmüller K, Hoffner S, Mack U, Aulmann S, Haberkorn U. Comparison of 99mtechnetium-pertechnetate and 123iodide SPECT with FDG-PET in patients suspicious for breast cancer. Cancer Biother Radiopharm. 2007;22:779-89 pubmed
  26. Bjørndal M, Sandmo Wilhelmsen K, Lu T, Jorde R. Prevalence and causes of undiagnosed hyperthyroidismin an adult healthy population. The Tromsø study. J Endocrinol Invest. 2008;31:856-60 pubmed
    ..The causes of subclinical hyperthyroidism have only been reported from clinical studies...
  27. Wojcik J, Grodzki T, Kozłowska I, Urbański S, Kubisa B. [Usefulness of the scintigraphic assessment of the thoracic splenosis -- a case report]. Pneumonol Alergol Pol. 2008;76:456-9 pubmed
    ..This confirmed the usefulness of scintigraphic assessment in preoperative diagnosis in order to avoid thoracotomy in such cases...
  28. Sippel R, Bianco J, Wilson M, Perlman S, Ozgul O, Mack E, et al. Can thallium-pertechnetate subtraction scanning play a role in the preoperative imaging for minimally invasive parathyroidectomy?. Clin Nucl Med. 2004;29:21-6 pubmed
    ..However, a significant number of patients with single gland disease have negative scans and are not considered for the minimally invasive procedure...
  29. Raafat B, Saleh A, Shafaa M, Khedr M, Ghafaar A. Ginkgo biloba and Angelica archangelica bring back an impartial hepatic apoptotic to anti-apoptotic protein ratio after exposure to technetium 99mTc. Toxicol Ind Health. 2013;29:14-22 pubmed publisher
    ..archangelica and G. biloba in a dose based on the animal body weight. Electron microscope photographing supported this finding...
  30. Fukata S, Hishinuma A, Nakatake N, Tajiri J. Diagnosis of iodide transport defect: do we need to measure the saliva/serum radioactive iodide ratio to diagnose iodide transport defect?. Thyroid. 2010;20:1419-21 pubmed publisher
    ..Herein, we describe a patient with ITD and discuss the features important for the diagnosis, focusing on whether or not measuring the saliva/serum radioactive iodide ratio is useful...
  31. Wilczek B, Sandelin K, Eriksson S, Larsson S, Jacobsson H. Sentinel node scintigraphy in breast cancer using a dual tracer technique. Nucl Med Commun. 2004;25:135-8 pubmed
    ..As this may reduce the detectability of weak 'hot spots', the number of lymph nodes detected at scintigraphy and at surgery in one group of patients was compared with that obtained in another group that had not received pertechnetate...
  32. Lumachi F, Fabbro M, Tregnaghi A, Antunovic L, Bui F, Cecchin D, et al. Fine-needle aspiration cytology and (99m)Tc-pertechnetate scintigraphy together in patients with differentiated thyroid carcinoma. Anticancer Res. 2010;30:3083-6 pubmed
    ..In conclusion, patients with 'cold' TN and FNAC suggesting follicular neoplasm should be considered at risk of having cancer...
  33. Ridone S, Matheoud R, Valzano S, Di Martino R, Vigna L, Brambilla M. Permeability of gloves used in nuclear medicine departments to [(99m)Tc]-pertechnetate and [(18)F]-fluorodeoxyglucose: radiation protection considerations. Phys Med. 2013;29:545-8 pubmed publisher
    ..This practice will provide a more careful service of radiation protection for nuclear medicine department staff. ..
  34. Boughattas S, Khochtali H, Arifa N, Degdegui M, Hassine H, Bakir A, et al. Preoperative scintigraphic visualization of an orbital metastasis before identification of carcinoma in a nonfunctioning thyroid nodule. Clin Nucl Med. 2004;29:249-50 pubmed
    ..I-131 scintigraphy performed before thyroidectomy showed intense uptake in an orbital metastasis despite the presence of an intact thyroid gland...
  35. Van De Flierdt E, Dropmann A, Bock J, Spelsberg F, Furst H. [Primary hyperparathyroidism: parathyroid scintigraphy and ultrasound in problem patients]. Chirurg. 2004;75:794-8 pubmed
  36. Hao L, Fang J, Hong Z, Xu Y, Liu Z. [Values of (99m)TcO(-)(4)thyroid imaging plus ultrasonography in the differential diagnoses of thyroid nodules]. Zhonghua Yi Xue Za Zhi. 2011;91:3210-3 pubmed
    ..To evaluate the diagnostic values of (99m)TcO(-)(4) thyroid imaging plus ultrasonography in the differentiation of benign and malignant thyroid nodules...
  37. Bryant A, Reid M, Oates M. A unique case of thyroid dysgenesis in a neonate. Clin Nucl Med. 2011;36:563-4 pubmed publisher
  38. Suga K, Kawakami Y, Koike H, Iwanaga H, Tokuda O, Okada M, et al. Lung ventilation-perfusion imbalance in pulmonary emphysema: assessment with automated V/Q quotient SPECT. Ann Nucl Med. 2010;24:269-77 pubmed publisher
    ..Tc-99m-Technegas-MAA single photon emission computed tomography (SPECT)-derived ventilation (V)/perfusion (Q) quotient SPECT was used to assess lung V-Q imbalance in patients with pulmonary emphysema...
  39. Barbosa V, Holanda C, Câmara A, Silva R, Oliveira D, Moreira J, et al. Trypanosoma cruzi: biodistribution of technetium-99m pertechnetate in infected rats. Exp Parasitol. 2009;123:309-12 pubmed publisher
    ..These results conclusively demonstrate that T. cruzi infection would be associated with changes in the biodistribution of (99m)TcO4- and in colon morphology, with potential clinical implications...
  40. Dolezal J, Vizda J. Experiences with detection of the ectopic gastric mucosa by means of Tc-99m pertechnetate disodium scintigraphy in children with lower gastrointestinal bleeding. Eur J Pediatr Surg. 2008;18:258-60 pubmed publisher
    ..Gastric mucosa may be present in Meckel's diverticulum and is associated with peptic ulcer disease and lower gastrointestinal (GI) bleeding; Tc-99m pertechnetate scintigraphy can help to make the diagnosis of ectopic gastric mucosa...
  41. Moreno S, Arnobio A, de Carvalho J, Nascimento L, Oliveira Timoteo M, Olej B, et al. The ingestion of a Nectandra membranacea extract changes the bioavailability of technetium-99m radiobiocomplex in rat organs. Biol Res. 2007;40:131-5 pubmed
    ..Therefore, precaution is suggested in the interpretation of nuclear medicine results in patients using this herb...
  42. Giovanella L, Suriano S, Ricci R, Ceriani L, Anton Verburg F. Postsurgical thyroid remnant estimation by (??m) Tc-pertechnetate scintigraphy predicts radioiodine ablation effectiveness in patients with differentiated thyroid carcinoma. Head Neck. 2011;33:552-6 pubmed publisher
  43. Cecchin D, Lumachi F, Marino F, Stramare R, Basso U, Grassetto G, et al. Thyroid C-cell hyperplasia shown by combined In-111 pentetreotide, Tc-99m pertechnetate, and Tc-99m MIBI scintigraphy. Clin Nucl Med. 2007;32:378-9 pubmed
  44. Souza D, Pereira M, Bernardo L, Carmo F, Fonseca A, Bernardo Filho M. An experimental model to study the effects of a senna extract on the blood constituent labeling and biodistribution of a radiopharmaceutical in rats. Clinics (Sao Paulo). 2011;66:483-6 pubmed
    ..Although these assays were performed in animals, our findings suggest that caution should be exercised when nuclear medicine examinations using Na??mTcO? are conducted in patients who are using senna extract...
  45. Hindie E, Ugur O, Fuster D, O Doherty M, Grassetto G, Urena P, et al. 2009 EANM parathyroid guidelines. Eur J Nucl Med Mol Imaging. 2009;36:1201-16 pubmed publisher
    ..Additional radiation to the patient should also be considered. The guidelines also discuss aspects related to radio-guided surgery of hyperparathyroidism and imaging of chronic kidney disease patients with secondary hyperparathyroidism...
  46. Bustani H, Colavolpe C, Imbert Joscht I, Havlik P, Pisano P, Guillet B. Chocolate intake associated with failed labeling of (99m)Tc red blood cells. J Nucl Med Technol. 2009;37:107-10 pubmed publisher
    ..Red blood cells (RBC) labeled in vivo with (99m)Tc-pertechnetate are used worldwide in nuclear medicine departments...
  47. Psimadas D, Baldi G, Ravagli C, Bouziotis P, Xanthopoulos S, Franchini M, et al. Preliminary evaluation of a 99mTc labeled hybrid nanoparticle bearing a cobalt ferrite core: in vivo biodistribution. J Biomed Nanotechnol. 2012;8:575-85 pubmed
    ..In conclusion the preliminary results for nanoparticles bearing a cobalt ferrite core justify further investigations towards potential hyperthermic applications, drug transportation and liver or spleen imaging...
  48. van Hoek I, Peremans K, Vandermeulen E, Duchateau L, Gommeren K, Daminet S. Effect of recombinant human thyroid stimulating hormone on serum thyroxin and thyroid scintigraphy in euthyroid cats. J Feline Med Surg. 2009;11:309-14 pubmed publisher
    ..We can conclude that 25 microg rhTSH increases pertechnetate uptake in the thyroid glands of cats, this should be taken into account when thyroid scintigraphy after rhTSH administration is interpreted...
  49. Basu S, Nair N. Dual ectopic thyroid. Indian Pediatr. 2006;43:741 pubmed
  50. Andersson J, Wilson J, Romaniuk J, McEwan A, Abrams D, McQuarrie S, et al. Separation of [(99m)Tc]pertechnetate and molybdate using polyethylene glycol coated C18 and C30 resins. Appl Radiat Isot. 2016;110:193-199 pubmed publisher
    ..The [(99m)Tc]pertechnetate recovery during the separation of cyclotron produced (99m)Tc from (100)Mo was 91.8±0.3% (n=2). The resultant product met relevant USP monograph specifications. ..
  51. Kim H, Chaudhuri T, Buchsbaum D, Wang D, Zinn K. High-resolution single-photon emission computed tomography and X-ray computed tomography imaging of Tc-99m-labeled anti-DR5 antibody in breast tumor xenografts. Mol Cancer Ther. 2007;6:866-75 pubmed
    ..Imaging could provide a mechanism to assess DR5 modulation when DR5 therapy is combined with chemotherapy and radiation, and thereby aid in optimizing the dosing schedule...
  52. Jiang J, Wei W, Feng Y, Zhou Y, Luo W, Yuan J, et al. [Application of 99mTc-DTPA in evaluation of blood-brain barrier permeability in patients receiving whole brain irradiation]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:329-30 pubmed
    ..To study the pattern of blood-brain barrier (BBB) permeability changes during whole brain radiotherapy (WBRT) for metastatic brain tumor...
  53. Fruhwirth G, Diocou S, Blower P, Ng T, Mullen G. A whole-body dual-modality radionuclide optical strategy for preclinical imaging of metastasis and heterogeneous treatment response in different microenvironments. J Nucl Med. 2014;55:686-94 pubmed publisher
    ..The goal was to develop a new highly sensitive and reliable preclinical longitudinal in vivo imaging model for this purpose, thereby facilitating discovery and validation of anticancer therapies or molecular imaging agents...