technetium compounds

Summary

Summary: Inorganic compounds that contain TECHNETIUM as an integral part of the molecule. Technetium 99m (m=metastable) is an isotope of technetium that has a half-life of about 6 hours. Technetium 99, which has a half-life of 210,000 years, is a decay product of technetium 99m.

Top Publications

  1. Jinno H, Ikeda T, Matsui A, Kitagawa Y, Kitajima M, Fujii H, et al. Sentinel lymph node biopsy in breast cancer using technetium-99m tin colloids of different sizes. Biomed Pharmacother. 2002;56 Suppl 1:213s-216s pubmed
    ..It was concluded that SLNB using the small-sized tin colloid was technically feasible and provided higher detection and identification rates than the regular-sized tin colloid...
  2. Plante M, Renaud M, Tetu B, Harel F, Roy M. Laparoscopic sentinel node mapping in early-stage cervical cancer. Gynecol Oncol. 2003;91:494-503 pubmed
    ..We aimed to determine the feasibility and accuracy of sentinel node (SN) mapping and its ability to predict the status of the regional nodal basin...
  3. Welch M, Lewis J. [Tc(CO)(3)](+) chemistry: a promising new concept for SPECT? Against. Eur J Nucl Med Mol Imaging. 2003;30:1302-4 pubmed
  4. Aliakbarian M, Memar B, Jangjoo A, Zakavi S, Reza Dabbagh Kakhki V, Aryana K, et al. Factors influencing the time of sentinel node visualization in breast cancer patients using intradermal injection of the radiotracer. Am J Surg. 2011;202:199-202 pubmed publisher
    ..The objective of our study was to determine the important factors that have influence on the time of sentinel node visualization using intradermal injection of (99m)Tc-antimony sulfide colloid...
  5. Kristen A, Schönland S, Remppis A, Hegenbart U, Schnabel P, Katus H, et al. [Risk stratification and treatment of cardiac amyloidoses]. Pathologe. 2009;30:212-8 pubmed publisher
    ..Referral to specialized centers is strongly recommended...
  6. Ishikawa H, Sato K, Mochizuki H. Optimal sentinel node examination and a new strategy for axillary control in breast cancer. Breast J. 2002;8:10-4 pubmed
    ..There is a possibility that additional axillary clearance is not needed for patients with a cancer area of less than approximately 20% in the SLN slice...
  7. Morota S, Koizumi M, Koyama M, Sugihara T, Tada K, Miyagi Y, et al. Radioactivity thresholds for sentinel node biopsy in breast cancer. Eur J Surg Oncol. 2006;32:1101-4 pubmed
    ..The aim of the present study is to clarify the level of radioactive lymph node should be biopsied after the most radioactive SN is removed...
  8. Palestro C, Love C, Tronco G, Tomas M. Role of radionuclide imaging in the diagnosis of postoperative infection. Radiographics. 2000;20:1649-60; discussion 1660-3 pubmed
    ..In general, the value of radionuclide imaging is maximized when used only in those patients for whom the results of anatomic imaging are negative, nondiagnostic, or at odds with the clinical impression...
  9. Gomes M, de Mattos D, de Souza Freitas R, Bezerra R, Bernardo Filho M. Study of the toxicological effect of mitomycin C in mice: alteration on the biodistribution of radiopharmaceuticals used for renal evaluations. Hum Exp Toxicol. 2001;20:193-7 pubmed
    ..05) and could be explained by the metabolization and/or therapeutic action of MMC. Studies with other radiopharmaceuticals are in progress...

More Information

Publications62

  1. Alonso O, Martinez M, Lago G, Espasandin J. Preoperative evaluation of sentinel lymph node status in melanoma by means of (99m)Tc-MIBI and lymphoscintigraphy: a case report. J Nucl Med Technol. 2001;29:152-3 pubmed
    ..This double-technique approach is technically feasible and has the potential of selecting a group of patients who might benefit from a selective complete lymphadenectomy...
  2. Ramsay S, LaBrooy J, Norton R, Webb B. Demonstration of different patterns of musculoskeletal, soft tissue and visceral involvement in melioidosis using 99m Tc stannous colloid white cell scanning. Nucl Med Commun. 2001;22:1193-9 pubmed
    ..Pulmonary disease was not necessarily associated with abnormal uptake. White cell scanning is a quick and effective way of assessing the extent of musculoskeletal, visceral and soft tissue disease in melioidosis...
  3. Wynchank S, Mann M, Fisher R, Dwyer E. Ultrasound as a screening study for gastro-oesophageal reflux in children. Ann Trop Paediatr. 1997;17:343-8 pubmed
    ..The 19/110 discordant results can be explained by several plausible mechanisms. It is concluded that ultrasound should be employed much more frequently as an initial investigation when pathological reflux is suspected in children...
  4. Gimbergues P, Abrial C, Durando X, Le Bouedec G, Cachin F, Penault Llorca F, et al. Sentinel lymph node biopsy after neoadjuvant chemotherapy is accurate in breast cancer patients with a clinically negative axillary nodal status at presentation. Ann Surg Oncol. 2008;15:1316-21 pubmed publisher
    ..The aim of our study was to determine clinicopathological factors that may influence the accuracy of SLN biopsy after NAC...
  5. Wild D, Wicki A, Mansi R, Behe M, Keil B, Bernhardt P, et al. Exendin-4-based radiopharmaceuticals for glucagonlike peptide-1 receptor PET/CT and SPECT/CT. J Nucl Med. 2010;51:1059-67 pubmed publisher
    ..The aim of this study was the preclinical evaluation of [Lys(40)(Ahx-DOTA-(68)Ga)NH(2)]-exendin-4 for PET/CT and [Lys(40)(Ahx-hydrazinonicotinamide [HYNIC]-(99m)Tc)NH(2)]-exendin-4 for SPECT/CT...
  6. Allegra C, Sarcinella R, Bartolo M. Morphologic and functional changes of the microlymphatic network in patients with advancing stages of primary lymphedema. Lymphology. 2002;35:114-20 pubmed
    ..Concomitantly, there was a prolongation in transport and disappearance of fluorescent dye and a progressive increase in endolymphatic and interstitial hydrostatic pressures...
  7. De Vincentis G, Scopinaro F, Varvarigou A, Ussof W, Schillaci O, Archimandritis S, et al. Phase I trial of technetium [Leu13] bombesin as cancer seeking agent: possible scintigraphic guide for surgery?. Tumori. 2002;88:S28-30 pubmed
    ..ABNs in turn are able to bind to mammalian and human receptors in vitro, and it is therefore interesting to study radioisotope-labeled bombesin (BN) and BN-like peptides as cancer seeking agents...
  8. Radovanovic Z, Golubovic A, Plzak A, Stojiljkovic B, Radovanovic D. Blue dye versus combined blue dye-radioactive tracer technique in detection of sentinel lymph node in breast cancer. Eur J Surg Oncol. 2004;30:913-7 pubmed
    ..In this study we compared the value of two methods for identification of sentinel node (SN) using either only blue dye or combination of blue dye and radioactive tracer...
  9. Jeong J, Hong M, Lee J, Son M, So Y, Lee D, et al. 99mTc-neolactosylated human serum albumin for imaging the hepatic asialoglycoprotein receptor. Bioconjug Chem. 2004;15:850-5 pubmed
  10. Lukens W, Shuh D, Schroeder N, Ashley K. Identification of the non-pertechnetate species in Hanford waste tanks, Tc(I)--carbonyl complexes. Environ Sci Technol. 2004;38:229-33 pubmed
    ..We report that the XANES spectra are most likely those of Tc(I)-carbonyl species, especially fac-Tc(CO)3(gluconate)(2-). This is further supported by EXAFS and 99Tc-NMR studies in nonradioactive simulants of these tank wastes...
  11. Karacalioglu O, Ilgan S, Arslan N, Ozguven M. Uterine doughnut in early proliferating phase: potential pitfall in gastrointestinal bleeding studies. Ann Nucl Med. 2003;17:685-7 pubmed
    ..The activity neither changed in shape nor showed distal movement with time excluding a GI hemorrhage. Uterus in early proliferating phase could be a potential pitfall in GI bleeding studies...
  12. Scolyer R, Thompson J, Li L, Beavis A, Dawson M, Doble P, et al. Failure to remove true sentinel nodes can cause failure of the sentinel node biopsy technique: evidence from antimony concentrations in false-negative sentinel nodes from melanoma patients. Ann Surg Oncol. 2004;11:174S-8S pubmed
    ..Our results suggest that an FN SNB can occur because of failure to remove the true SN as well as histopathologic misdiagnosis...
  13. Ballinger J, Cooper M, Mather S. Re: controversies--[Tc(CO)3]+ chemistry: a promising new concept for SPET?. Eur J Nucl Med Mol Imaging. 2004;31:304-5 pubmed
  14. Tomita T, Okugawa T, Yamasaki T, Kondo T, Toyoshima F, Sakurai J, et al. Use of scintigraphy to evaluate gastric accommodation and emptying: comparison with barostat. J Gastroenterol Hepatol. 2013;28:106-11 pubmed publisher
    ..Therefore, to clarify the usefulness of scintigraphy as a technique for assessing gastric accommodation, we compared scintigraphy with barostat, the gold standard modality...
  15. Malde R, Agrawal H, Ghosh S, Dinshaw K. Vanishing bone disease involving the pelvis. J Cancer Res Ther. 2005;1:227-8 pubmed
    ..However the biopsy and Positron emission tomography (PET) scan ruled out any active disease. Like in most other cases this was possibly a self-limited disease where bone resorption had spontaneously arrested...
  16. Jambor I, Kuisma A, Ramadan S, Huovinen R, Sandell M, Kajander S, et al. Prospective evaluation of planar bone scintigraphy, SPECT, SPECT/CT, 18F-NaF PET/CT and whole body 1.5T MRI, including DWI, for the detection of bone metastases in high risk breast and prostate cancer patients: SKELETA clinical trial. Acta Oncol. 2016;55:59-67 pubmed publisher
    ..5 Tesla magnetic resonance imaging (MRI), including diffusion weighted imaging, (wbMRI+DWI) for the detection of bone metastases in high risk breast and prostate cancer patients...
  17. Ting A, Cumarasingam B, Szeto E. Successful internal mammary visualization with periareolar injections of Tc-99m antimony sulfur colloid in sentinel node breast lymphoscintigraphy. Clin Nucl Med. 2006;31:593-7 pubmed
    ..One of the main criticisms, however, is the widely reported inability to detect internal mammary nodes. This contrasts with our clinical experience using Tc-99m antimony sulfur colloid, in which internal mammary nodes are commonly seen...
  18. Kosugi S, Nakagawa S, Kanda T, Odano I, Yajima K, Kaneko K, et al. Radio-guided sentinel node mapping in patients with superficial esophageal carcinoma: feasibility study. Minim Invasive Ther Allied Technol. 2007;16:181-6 pubmed
    ..8% (7 of 9), and the false-negative rate was 100% (2 of 2). The present study showed that radio-guided sentinel node detection is insufficiently reliable at present due to the high false-negative rate and low accuracy...
  19. Thipyapong K, Uehara T, Tooyama Y, Braband H, Alberto R, Arano Y. Insight into technetium amidoxime complex: oxo technetium(V) complex of N-substituted benzamidoxime as new basic structure for molecular imaging. Inorg Chem. 2011;50:992-8 pubmed publisher
    ..The (99g)Tc-MBHam proved to be identical with the (99m)Tc-MBHam prepared at the no-carrier-added level by comparison of their HPLC profiles...
  20. Makis W, Robinson D, McEwan A, Riauka T. Chest X-ray Artifact Caused by Bilateral 99mTc-Antimony Trisulfite Injection for Sentinel Node Imaging in a Patient With Breast Cancer. Clin Nucl Med. 2016;41:319-20 pubmed publisher
    ..Radiation exposure to the x-ray technologist was determined to be similar to 8 hours of naturally occurring background radiation (?2.96 ?Sv). ..
  21. von Guggenberg E, Behe M, Behr T, Saurer M, Seppi T, Decristoforo C. 99mTc-labeling and in vitro and in vivo evaluation of HYNIC- and (Nalpha-His)acetic acid-modified [D-Glu1]-minigastrin. Bioconjug Chem. 2004;15:864-71 pubmed
    ..Despite promising properties concerning receptor binding, internalization, and in vitro stability, 99mTc-(Nalpha-His)Ac-MG showed low tumor uptake in vivo...
  22. Tisato F, Bolzati C, Porchia M, Refosco F. Contribution of electrospray mass spectrometry for the characterization, design, and development of nitrido technetium and rhenium heterocomplexes as potential radiopharmaceuticals. Mass Spectrom Rev. 2004;23:309-32 pubmed
  23. Ota T, Kusaka S, Mizuno M. A splenic pseudotumor: an accessory spleen. Ann Nucl Med. 2003;17:159-60 pubmed
    ..An accessory spleen was considered most likely, but the differential diagnosis still included malignant lymphoma and metastatic tumor. The diagnosis was obtained by technetium-99m Sn colloid scintigraphy...
  24. Salgüero Fernández I, Rios Buceta L, Jaén Olasolo P. [Sentinel lymph node in nonmelanoma skin cancer]. Actas Dermosifiliogr. 2011;102:589-98 pubmed publisher
    ..This critical review of the literature on the various skin tumors in which sentinal node biopsy has been practiced discusses the usefulness of this procedure...
  25. Carter N, Eustance C, Barrington S, O Doherty M, Coakley A. Imaging of abdominal infection using 99m Tc stannous fluoride colloid labelled leukocytes. Nucl Med Commun. 2002;23:153-60 pubmed
  26. Koizumi M, Nomura E, Yamada Y, Takiguchi T, Makita M, Iwase T, et al. Radioguided sentinel node detection in breast cancer patients: comparison of 99mTc phytate and 99mTc rhenium colloid efficacy. Nucl Med Commun. 2004;25:1031-7 pubmed
    ..Radioguided sentinel node biopsy (SNB) of breast cancer patients has become a standard method for detecting early stage breast cancer. However, no standard radiopharmaceutical exists...
  27. Yararbas U, Argon A, Yeniay L, Zengel B, Kapkac M. The effect of radiocolloid preference on major parameters in sentinel lymph node biopsy practice in breast cancer. Nucl Med Biol. 2010;37:805-10 pubmed publisher
    ..The possible effects of radiocolloid preference on sentinel lymph node biopsy (SLNB) were investigated...
  28. Liptay M. Commentary on sentinel lymph node identification with technetium-99m tin colloid in non-small cell lung cancer. J Thorac Cardiovasc Surg. 2002;124:428-30 pubmed
  29. Zhu Z, Wang Y, Zhang Y, Liu G, Liu N, Rusckowski M, et al. A novel and simplified route to the synthesis of N3S chelators for 99mTc labeling. Nucl Med Biol. 2001;28:703-8 pubmed
    ..We conclude that this synthesis route provides a simplified path to the synthesis of N(3)S chelators which in principle may be used to incorporate any natural or unnatural amino acid...
  30. Ristow O, Gerngroß C, Schwaiger M, Hohlweg Majert B, Kehl V, Jansen H, et al. Is bone turnover of jawbone and its possible over suppression by bisphosphonates of etiologic importance in pathogenesis of bisphosphonate-related osteonecrosis?. J Oral Maxillofac Surg. 2014;72:903-10 pubmed publisher
  31. Bahar R, al Mohannadi S, Wafai I, Al Suhaili A, Abdel Dayem H. Acute intrahepatic biliary obstruction caused by hydatid cysts. Correlation between various imaging techniques. Clin Nucl Med. 1988;13:334-6 pubmed
    ..The case illustrates the value of dynamic functional information provided by Tc-99m-HIDA imaging over noninvasive modalities that demonstrate structural changes, such as ultrasound, computed tomography, and tin colloid liver imaging...
  32. Mesina C, Pasalega M, Calotă F, Meşină M, Vilcea D, Persu B, et al. [Sentinel nodes in patients with breast cancer]. Chirurgia (Bucur). 2006;101:359-64 pubmed
    ..Finally, we come up in the conclusion that the identification of the sentinel nodes is useful and possible for majority of the patients with breast cancer T1 or T2N0M0...
  33. Argon A, Duygun U, Acar E, Daglioz G, Yenjay L, Zekioglu O, et al. The use of periareolar intradermal Tc-99m tin colloid and peritumoral intraparenchymal isosulfan blue dye injections for determination of the sentinel lymph node. Clin Nucl Med. 2006;31:795-800 pubmed
  34. Peleg U, Perez R, Raveh D, Berelowitz D, Cohen D. Stratification for malignant external otitis. Otolaryngol Head Neck Surg. 2007;137:301-5 pubmed
    ..To propose a CT-based method for early identification of severe cases of malignant external otitis (MEO) by correlating between initial CT findings and clinical course...
  35. Di Bella G, Minutoli F, Mazzeo A, Vita G, Oreto G, Carerj S, et al. MRI of cardiac involvement in transthyretin familial amyloid polyneuropathy. AJR Am J Roentgenol. 2010;195:W394-9 pubmed publisher
    ..The purpose of this study was to evaluate cardiac MRI features in a group of patients with transthyretin familial amyloid polyneuropathy (FAP)...
  36. Botha U, Pilloy W, Strydom W. Importance of cholescintigraphy and inferior vena cava flow studies in the differential diagnosis of hepatocellular carcinoma. Am J Physiol Imaging. 1989;4:55-61 pubmed
    ..Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklear medizin. Erganzungsband 126:47-52 (1977). The results were compared with data previously collected in patients without liver disease (control) and other liver pathologies...
  37. Iznaga Escobar N, Morales A, Duconge J, Torres I, Fernandez E, Gomez J. Pharmacokinetics, biodistribution and dosimetry of 99mTc-labeled anti-human epidermal growth factor receptor humanized monoclonal antibody R3 in rats. Nucl Med Biol. 1998;25:17-23 pubmed
    ..On the basis of the pharmacokinetics, biodistribution and internal radiation dosimetry information obtained in this study, a diagnostic phase I clinical trial with 99mTc-labeled humanized MAb R3 conjugate in patients should be supported...
  38. Thomsen J, Sørensen J, Grupe P, Krogdahl A. Sentinel lymph node biopsy in oral cancer: validation of technique and clinical implications of added oblique planar lymphoscintigraphy and/or tomography. Acta Radiol. 2005;46:569-75 pubmed
  39. Kakite S, Tanabe Y, Kinoshita F, Harada H, Ogawa T. Clinical usefulness of In-111 chloride and Tc-99m Sn colloid scintigraphy in the diagnosis of intrathoracic extramedullary hematopoiesis. Ann Nucl Med. 2005;19:317-20 pubmed
  40. Calmanovici G. Re: A. Amman, et al., Surfactant protein B labelled with [(99m)Tc(CO)(3)(H(2)O)(3)](+) retains biological activity in vitro. Nuc. Med. Biol. 28 (2001) 243-250. Nucl Med Biol. 2002;29:131; author reply 133 pubmed
  41. Lukens W, Bucher J, Edelstein N, Shuh D. Products of pertechnetate radiolysis in highly alkaline solution: structure of TcO2 x xH2O. Environ Sci Technol. 2002;36:1124-9 pubmed
    ..The properties of the Tc(IV) alkoxide complexes were determined and are consistent with those observed for the soluble, lower-valent technetium complexes that complicate the treatment of HLW at the Hanford site...
  42. Tsunoda N, Iwata H, Sarumaru S, Mizutani M, Iwase T, Miura S. Combination of subareolar blue dye and peritumoral RI for sentinel lymph node biopsy. Breast Cancer. 2002;9:323-8 pubmed
    ..The aim of this study was to determine the optimal technique for sentinel lymph node biopsy (SLNB)...
  43. Gallagher H, Ramsay S, Barnes J, Maggs J, Cassidy N, Ketheesan N. Neutrophil labeling with [(99m)Tc]-technetium stannous colloid is complement receptor 3-mediated and increases the neutrophil priming response to lipopolysaccharide. Nucl Med Biol. 2006;33:433-9 pubmed
    ..Fluorescence-activated cell sorter (FACS) analysis side scatter measurements can assess neutrophil activation and priming...
  44. Matrai Z, Toth L, Saeki T, Sinkovics I, Godény M, Takeuchi H, et al. [The potential role of SPECT/CT in the preoperative detection of sentinel lymph nodes in breast cancer]. Orv Hetil. 2011;152:678-88 pubmed publisher
    ..It is concluded that 3D SPECT/CT increases the success rate and quality of preoperative sentinel node identification, and is capable of providing a more accurate staging of breast cancer patients in routine clinical practice...
  45. Aburano T, Yokoyama K, Shuke N, Kinuya S, Takayama T, Tonami N, et al. The role of Tc-99m IDA hepatobiliary and Tc-99m colloid hepatic imaging in primary biliary cirrhosis. Clin Nucl Med. 1991;16:4-9 pubmed
    ..Tc-99m colloid imaging also effectively evaluated progression...
  46. Cuccurullo V, Cascini G, Rossi A, Tamburrini O, Rotondo A, Mansi L. Pathophysiological premises to radiotracers for bone metastases. Q J Nucl Med Mol Imaging. 2011;55:353-73 pubmed
    ..At the end, the possibility to use diagnostic radiotracers to act both in recruiting patients with bone metastases undergoing radionuclide therapy and for their dosimetric evaluation is also discussed...
  47. Nomori H, Watanabe K, Ohtsuka T, Naruke T, Suemasu K. In vivo identification of sentinel lymph nodes for clinical stage I non-small cell lung cancer for abbreviation of mediastinal lymph node dissection. Lung Cancer. 2004;46:49-55 pubmed
  48. Beeres F, Hogervorst M, den Hollander P, Rhemrev S. Outcome of routine bone scintigraphy in suspected scaphoid fractures. Injury. 2005;36:1233-6 pubmed
    ..Routine bone scintigraphy (BS) is often advocated if there are clinical signs of a scaphoid fracture without radiological evidence. However, the results require careful therapeutic management...
  49. Murata H, Horie N, Matsui T, Akai T, Ueda H, Oshima Y, et al. Clinical usefulness of thallium-201 scintigraphy and magnetic resonance imaging in the diagnosis of chondromyxoid fibroma. Ann Nucl Med. 2008;22:221-4 pubmed publisher
    ..Contrast-enhanced MR imaging and thallium-201 scintigraphy may be useful to distinguish CMF from benign bone tumors or chondrosarcoma...
  50. Bayly S, Fisher C, Storr T, Adam M, Orvig C. Carbohydrate conjugates for molecular imaging and radiotherapy: 99mTc(I) and 186Re(I) tricarbonyl complexes of N-(2'-Hydroxybenzyl)-2-amino-2-deoxy-D-glucose. Bioconjug Chem. 2004;15:923-6 pubmed
    ..At the tracer-level, labeling of HL2 with [99mTc(CO)3(H2O)3]+ and [186Re(CO)3(H2O)3]+ was achieved in aqueous conditions in 95 +/- 2% and 94 +/- 3% average radiochemical yields, respectively...
  51. Lu J, Le T, Traore D, Wilce M, Bond A, Martin L. Synthetic precursors for TCNQF4(2-) compounds: synthesis, characterization, and electrochemical studies of (Pr4N)2TCNQF4 and Li2TCNQF4. J Org Chem. 2012;77:10568-74 pubmed publisher
    ..The structures of single crystals of (Pr(4)N)(2)TCNQF(4) and Pr(4)NTCNQF(4) have been determined by X-ray crystallography. These TCNQF(4)(2-) salts will provide useful precursors for the synthesis of derivatives of the dianions...
  52. Aburano T, Taniguchi M, Hisada K, Miyazaki Y, Kakuma K, Fujioka M. Discordant hepatic uptake of Tc-99m HIDA and Tc-99m colloid in a patient with segmental biliary obstruction. Clin Nucl Med. 1988;13:599-601 pubmed
    ..At surgery this was confirmed, and a 2 cm mass encasing the right hepatic duct was identified. It should be included in the gamut of discordant hepatic uptake of Tc-99m IDA and Tc-99m colloid...
  53. Kaufmann R. Malignant melanoma--sentinel lymph node biopsy and surgical procedures. Front Radiat Ther Oncol. 2006;39:127-39 pubmed