technetium tc 99m sulfur colloid

Summary

Summary: A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, liver, and spleen.

Top Publications

  1. Newman E, Newman L. Lymphatic mapping techniques and sentinel lymph node biopsy in breast cancer. Surg Clin North Am. 2007;87:353-64, viii pubmed
    ..Lymphatic mapping with sentinel lymph node biopsy has emerged as an effective and safe alternative to the ALND for detecting axillary metastases. This article discusses some lymphatic mapping methodology...
  2. Krag D, Harlow S, Weaver D, Ashikaga T. Radiolabeled sentinel node biopsy: collaborative trial with the National Cancer Institute. World J Surg. 2001;25:823-8 pubmed
    ..Major endpoints of this trial include long-term regional control and survival...
  3. Daniel T, Altes T, Rehm P, Williams M, Jones D, Stolin A, et al. A novel technique for localization and excisional biopsy of small or ill-defined pulmonary lesions. Ann Thorac Surg. 2004;77:1756-62; discussion 1762 pubmed
    ..The purpose of this study was to develop and evaluate radiotracer-guided localization of small or ill-defined pulmonary nodules for thoracoscopic excisional biopsy...
  4. Chagpar A, Martin R, Chao C, Wong S, Edwards M, Tuttle T, et al. Validation of subareolar and periareolar injection techniques for breast sentinel lymph node biopsy. Arch Surg. 2004;139:614-8; discussion 618-20 pubmed
    ..Subareolar or periareolar injection of radioactive technetium sulfur colloid is equivalent to other injection techniques for breast cancer sentinel lymph node (SLN) biopsy...
  5. Tukenmez M, Erbil Y, Barbaros U, Dural C, Salmaslioglu A, Aksoy D, et al. Radio-guided nonpalpable metastatic lymph node localization in patients with recurrent thyroid cancer. J Surg Oncol. 2007;96:534-8 pubmed
    ..In conclusion, the radio-guided nonpalpable lesion localization technique can be performed safely for the detection and excision of metastatic foci...
  6. McMasters K, Wong S, Martin R, Chao C, Tuttle T, Noyes R, et al. Dermal injection of radioactive colloid is superior to peritumoral injection for breast cancer sentinel lymph node biopsy: results of a multiinstitutional study. Ann Surg. 2001;233:676-87 pubmed
    ..To determine the optimal radioactive colloid injection technique for sentinel lymph node (SLN) biopsy for breast cancer...
  7. Tafra L, Lannin D, Swanson M, Van Eyk JJ -, Verbanac K, Chua A, et al. Multicenter trial of sentinel node biopsy for breast cancer using both technetium sulfur colloid and isosulfan blue dye. Ann Surg. 2001;233:51-9 pubmed
  8. Radowsky J, Baines L, Howard R, Shriver C, Buckenmaier C, Stojadinovic A. Pain ratings by patients and their providers of radionucleotide injection for breast cancer lymphatic mapping. Pain Med. 2012;13:670-6 pubmed publisher
  9. Yuan Z, Luo Q, Chen L, Luo Q, Zhu R. The role of radionuclide lymphoscintigraphy in chyluria. Hell J Nucl Med. 2010;13:238-40 pubmed
    ..In conclusion, radionuclide lymphoscintigraphy is a useful noninvasive method for detecting the origin site of chyluria, and for providing reliable information to perform safe operation...

More Information

Publications62

  1. Pandit Taskar N, Gemignani M, Lyall A, Larson S, Barakat R, Abu Rustum N. Single photon emission computed tomography SPECT-CT improves sentinel node detection and localization in cervical and uterine malignancy. Gynecol Oncol. 2010;117:59-64 pubmed publisher
    ..Planar imaging helps to localize hot nodes but lacks accuracy of the anatomic location of those nodes. In this study, we compared SPECT-CT to planar LSG in endometrial and cervical cancer to assess its ability to localize SLN...
  2. Li Z, Hu G, Lei C, Zhong S, Li B, Hong S, et al. [Localization of sentinel lymph node with radionuclide in clinically N0 laryngeal and hypopharyngeal cancers]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009;44:395-9 pubmed
    ..To analyze the characteristic of the radioactive lymph node with metastatic disease and to explore the method of the localization of sentinel lymph node (SLN) with radionuclide in N0 clinically laryngeal and hypopharyngeal cancer...
  3. Firat O, Mutlukoca N, Makay O, Yilmaz F, Omur O, Kitapcioglu G, et al. Portal hyperfusion or hepatic venous congestion: which one affects Kupffer cell function more?. Exp Clin Transplant. 2009;7:40-4 pubmed
    ..The aim of this study was to investigate the effects of vascular streams modified by portal hyperperfusion and hepatic venous congestion on Kupffer cell function...
  4. Clark A, Chambers C, Muir D, Newhouse M, Paboojian S, Schuler C. The effect of biphasic inhalation profiles on the deposition and clearance of coarse (6.5 microm) bolus aerosols. J Aerosol Med. 2007;20:75-82 pubmed
    ..Twenty-four-hour clearance and Penetration Index measurements were used as a marker for peripheral deposition, and the data show a clear correlation between Penetration Index and 24-h retention...
  5. van Rijk M, Nieweg O, Kroon B. Re: Gad D, Hoiland-Carlesen PF, Bartram P, et al.: staging patients with cutaneous malignant melanoma by same day lymphoscintigraphy and sentinel lymph node biopsy: a single-institutional experience with emphasis on recurrence. J Surg Oncol. 2006;94:170-1; author reply 172 pubmed
  6. Terada A, Hasegawa Y, Goto M, Sato E, Hyodo I, Ogawa T, et al. Sentinel lymph node radiolocalization in clinically negative neck oral cancer. Head Neck. 2006;28:114-20 pubmed
    ..The aim of this article is to report the results of our feasibility study and clinical application of sentinel lymph node (SLN) radiolocalization and biopsy in patients with clinically negative neck oral cancer...
  7. Ponto J. Stability of filtered technetium TC-99m sulfur colloid. J Am Pharm Assoc (2003). 2005;45:92-4 pubmed
  8. Babiera G, Delpassand E, Breslin T, Ross M, Ames F, Singletary S, et al. Lymphatic drainage patterns on early versus delayed breast lymphoscintigraphy performed after injection of filtered Tc-99m sulfur colloid in breast cancer patients undergoing sentinel lymph node biopsy. Clin Nucl Med. 2005;30:11-5 pubmed
  9. Zhang X, Du A, Geng C, Guo F, He M, Gu F, et al. Clinical and experimental observations of peripheral blood leukocytes and nucleated bone marrow cells after local irradiation. Minerva Med. 2014;105:51-6 pubmed
    ..Aim of the study was to observe the impact of bone marrow damage induced by local irradiation on leukopenia...
  10. Ponzo F, Zhuang H, Liu F, Lacorte L, Moussavian B, Wang S, et al. Tc-99m sulfur colloid and Tc-99m tagged red blood cell methods are comparable for detecting lower gastrointestinal bleeding in clinical practice. Clin Nucl Med. 2002;27:405-9 pubmed
  11. Tuttle T, Zogakis T, Dunst C, Zera R, Singletary S. A review of technical aspects of sentinel lymph node identification for breast cancer. J Am Coll Surg. 2002;195:261-8 pubmed
  12. Arcan P, Ibis E, Aras G, Cam R, Kucuk N. Identification of sentinel lymph node in stage I-II breast cancer with lymphoscintigraphy and surgical gamma probe: comparison of Tc-99m MIBI and Tc-99m sulfur colloid. Clin Nucl Med. 2005;30:317-21 pubmed
  13. Krishnaiah Y, Satyanarayana S, Prasad Y, Rao S. In vivo evaluation of 99mTc-DTPA and 99mTc-sulphur colloid as tracers in colonic drug delivery systems using gamma scintigraphy in volunteers. J Pharm Pharm Sci. 2002;5:24-8 pubmed
    ..The suitability of 99mTc-diethylenetriaminepenta- acetic acid (DTPA) and 99mTc-sulphur colloid (99mTc-SC) as tracers in gamma scintigraphy for the evaluation of colon-specific drug delivery systems was assessed in healthy volunteers...
  14. Southam D, Dolovich M, O Byrne P, Inman M. Distribution of intranasal instillations in mice: effects of volume, time, body position, and anesthesia. Am J Physiol Lung Cell Mol Physiol. 2002;282:L833-9 pubmed
    ..When using intranasal instillation, the relative distribution between the URT and LRT and the gastrointestinal tract is heavily influenced by delivery volume and level of anesthesia...
  15. Bhattacharya A, Mittal B. Peritoneo-scrotal communication: demonstration by 99mtechnetium sulphur colloid scintigraphy. Australas Radiol. 2005;49:335-7 pubmed
    ..We present a case report to illustrate the diagnostic use of radionuclide scintigraphy in this group of patients...
  16. Schraml F, Krueger W. Presentation of gastric carcinoma on a radionuclide gastric-emptying study. Clin Nucl Med. 2005;30:574-6 pubmed
    ..This case, in which the images suggested a space-occupying lesion(s), emphasizes the importance of careful examination for "pathoanatomy" as well as pathophysiology in functional imaging...
  17. Zogakis T, Wetherille R, Christensen R, Ose K, Friedman J, Colbert M, et al. Intraoperative subareolar injection of 99mTc-labeled sulfur colloid results in consistent sentinel lymph node identification. Ann Surg Oncol. 2005;12:167-72 pubmed
    ..We hypothesize that TcSC will travel to the SLN within minutes after injection into the subareolar (SA) lymphatics, thus making an intraoperative injection technique feasible...
  18. Funahashi K, Ryu M, Miki T, Koike J, Shimada M, Teramoto T. [Clinical significance and problems of sentinel node identification for individualization of rectal cancer therapy]. Gan To Kagaku Ryoho. 2005;32:269-73 pubmed
    ..Although the role this technique plays in the individualization of the therapy for rectal cancer will be large in the near future, many problems remain to be solved in the exact identification of SLN...
  19. Trocha S, Nora D, Saha S, Morton D, Wiese D, Bilchik A. Combination probe and dye-directed lymphatic mapping detects micrometastases in early colorectal cancer. J Gastrointest Surg. 2003;7:340-5; discussion 345-6 pubmed
  20. Cavadas P, Thione A, Carballeira A, Dominguez P. Lymphedema after upper limb transplantation: scintigraphic study in 3 patients. Ann Plast Surg. 2013;71:114-7 pubmed publisher
    ..The study demonstrates objectively that lymphatic circulation can reconnect spontaneously in hand transplantations, although not in a homogeneously efficient way...
  21. Govender S, Harman J, Ramsaroop R. Sentinel lymph node biopsy in breast cancer: the lymphatic is as important as the lymph node. ANZ J Surg. 2003;73:552-3 pubmed
  22. Saha S, Dan A, Beutler T, Wiese D, Schochet E, Badin J, et al. Sentinel lymph node mapping technique in colon cancer. Semin Oncol. 2004;31:374-81 pubmed
    ..Those patients who are upstaged can then benefit from adjuvant chemotherapy, which has been shown to improve survival of colon cancer patients with nodal disease by at least 33%...
  23. Laway B, Malik T, Khan S, Rather T. Prevalence of abnormal gastric emptying in asymptomatic women with newly detected diabetes and its reversibility after glycemic control-a prospective case control study. J Diabetes Complications. 2013;27:78-81 pubmed publisher
    ..The aim of the study was to investigate the gastric emptying time in people with newly detected diabetes before and after control of diabetes compared with healthy controls...
  24. Albo D, Wayne J, Hunt K, Rahlfs T, Singletary S, Ames F, et al. Anaphylactic reactions to isosulfan blue dye during sentinel lymph node biopsy for breast cancer. Am J Surg. 2001;182:393-8 pubmed
    ..Cases of anaphylactic reaction to the isosulfan blue dye used during SLNB have recently been reported. No study on the incidence of serious anaphylactic reactions during SLNB for breast cancer has been reported...
  25. Johnson C, Boneti C, Korourian S, Adkins L, Klimberg V. Intraoperative injection of subareolar or dermal radioisotope results in predictable identification of sentinel lymph nodes in breast cancer. Ann Surg. 2011;254:612-8 pubmed publisher
    ..Our objective is to prove that injection of technetium-99m (Tc99) sulfur colloid in a subareolar manner, after induction of anesthesia, is a safe and effective technique for sentinel lymph node identification in breast cancer patients...
  26. Wang L, Yu J, Wang Y, Zuo W, Gao Y, Fan J, et al. Preoperative lymphoscintigraphy predicts the successful identification but is not necessary in sentinel lymph nodes biopsy in breast cancer. Ann Surg Oncol. 2007;14:2215-20 pubmed
    ..Although preoperative lymphoscintigraphy in sentinel lymph node biopsy (SLNB) for breast cancer patients is undergone commonly, its clinical significance remains controversial...
  27. Krynyckyi B, Chun H, Kim H, Eskandar Y, Kim C, Machac J. Factors affecting visualization rates of internal mammary sentinel nodes during lymphoscintigraphy. J Nucl Med. 2003;44:1387-93 pubmed
    ..We observed a marked increase in our IM SN detection rate after 2 factors were changed simultaneously: depth of perilesional injection and dose...
  28. Tei K, Takinami S, Yamazaki Y, Totsuka Y. Scintigraphic method to detect silent aspiration during sleep in postsurgical patients with oral cancer. Head Neck. 2003;25:245-50 pubmed
    ..A simple method to detect silent aspiration during sleep has not been established in postsurgical oral cancer patients...
  29. Ponto J, Graham M, Bricker J. Alternatives to technetium 99m pentetate for radioaerosol inhalation lung imaging. J Am Pharm Assoc (Wash). 2002;42:112-4 pubmed
  30. Jensen J, Gray R, Wasif N, Roarke M, Casey W, Kreymerman P, et al. Can lymphatic drainage of head and neck melanoma be predicted?. J Surg Oncol. 2011;103:751-5 pubmed publisher
    ..The lymphatic drainage patterns of the head and neck (H&N) is complex. Therefore, identification of the sentinel lymph node (SLN) for H&N melanoma can be challenging...
  31. Duncan M, Cech A, Wechter D, Moonka R. Criteria for establishing the adequacy of a sentinel lymphadenectomy. Am J Surg. 2004;187:639-42; discussion 642 pubmed
    ..Criteria are needed that could be used to terminate a sentinel lymphadenectomy for breast cancer prior to removing every sentinel lymph node, without increasing false negative rates...
  32. Thompson M, Korourian S, Henry Tillman R, Adkins L, Mumford S, Westbrook K, et al. Axillary reverse mapping (ARM): a new concept to identify and enhance lymphatic preservation. Ann Surg Oncol. 2007;14:1890-5 pubmed
    ..Mapping the drainage of the arm with blue dye (axillary reverse mapping, ARM) decreases the likelihood of disruption of lymphatics and subsequent lymphedema...
  33. Menes T, Tartter P, Mizrachi H, Constantino J, Estabrook A, Smith S. Breast cancer patients with pN0(i+) and pN1(mi) sentinel nodes have high rate of nonsentinel node metastases. J Am Coll Surg. 2005;200:323-7 pubmed
    ..2 mm but < 2 mm are designated pN1(mi). We examined the association between size of sentinel node metastases and rate of nonsentinel node metastases, specifically in the subgroup of patients with micrometastases...
  34. van der Ploeg I, Valdes Olmos R, Kroon B, Nieweg O. Tumor-positive sentinel node biopsy of the groin in clinically node-negative melanoma patients: superficial or superficial and deep lymph node dissection?. Ann Surg Oncol. 2008;15:1485-91 pubmed publisher
    ..The purposes of the current study were to investigate the pathological findings, the lymph node recurrences and (disease-free) survival associated with this approach...
  35. Ahrendt G, Laud P, Tjoe J, Eastwood D, Walker A, Otterson M, et al. Does breast tumor location influence success of sentinel lymph node biopsy?. J Am Coll Surg. 2002;194:278-84 pubmed
    ..We undertook a prospective study in a single institution series to evaluate multiple variables that could adversely affect SLN identification rates...
  36. Arciero C, Henry L, Howard R, Peoples G, Bilchik A, Avital I, et al. Technical effects of adding 1 % lidocaine to technetium sulfur colloid for sentinel lymphatic mapping in early breast cancer: analysis of data from a double-blind randomized controlled trial. Ann Surg Oncol. 2013;20:2548-55 pubmed publisher
    ..A previous randomized controlled trial showed that adding lidocaine to Tc-99m significantly reduced radioisotope injection-related pain. We tested whether 1 % lidocaine admixed with Tc-99m affects feasibility of SLN mapping...
  37. Resende V, Petroianu A. [Functions of the splenic remnant after subtotal splenectomy for treatment of severe splenic injuries]. Rev Assoc Med Bras (1992). 2002;48:26-31 pubmed
    ..To evaluate clinical and laboratory variables in patients submitted to subtotal splenectomy...
  38. Meade R, Teotia S, Griffeth L, Barton F. Facelift and patterns of lymphatic drainage. Aesthet Surg J. 2012;32:39-45 pubmed publisher
    ..It has commonly been assumed that deeper facelift dissection causes greater and more prolonged swelling...
  39. Lambaudie E, Collinet P, Narducci F, Sonoda Y, Papageorgiou T, Carpentier P, et al. Laparoscopic identification of sentinel lymph nodes in early stage cervical cancer: prospective study using a combination of patent blue dye injection and technetium radiocolloid injection. Gynecol Oncol. 2003;89:84-7 pubmed
    ..To determine the feasibility of intraoperative radioisotopic mapping using an endoscopic gamma probe associated with patent blue dye injection in patients with early stage cervical cancer...
  40. El Espera I, Blondet C, Moullart V, Saidi L, Havet E, Mertl P, et al. The usefulness of 99mTc sulfur colloid bone marrow scintigraphy combined with 111In leucocyte scintigraphy in prosthetic joint infection. Nucl Med Commun. 2004;25:171-5 pubmed
    ..To assess the extent to which bone marrow scintigraphy (BMS) makes the interpretation of leucocyte scintigraphy (LS) easier and improves its diagnostic value...
  41. Liu S, Chang W, Kao P, Lo Y, Yang C, Tsai C, et al. Lymphoscintigraphy and intraoperative gamma probe-directed sentinel lymph node mapping in patients with malignant melanoma. J Formos Med Assoc. 2004;103:41-6 pubmed
    ..This study evaluated the usefulness of SLN detection by lymphoscintigraphy and excision with intraoperative gamma probe in Taiwanese patients with malignant melanoma...
  42. Ballester M, Rouzier R, Coutant C, Kerrou K, Darai E. Limits of lymphoscintigraphy for sentinel node biopsy in women with endometrial cancer. Gynecol Oncol. 2009;112:348-52 pubmed publisher
    ..This technique requires a preoperative lymphoscintigraphy. The aim of this study was to evaluate the limits of day-before preoperative lymphoscintigraphy to SLN biopsy...
  43. Ziessman H, Okolo P, Mullin G, Chander A. Liquid gastric emptying is often abnormal when solid emptying is normal. J Clin Gastroenterol. 2009;43:639-43 pubmed
    ..Our initial purpose was to review the results in those patients. The surprising results led us to initiate a prospective investigation to more directly determine the relative value of solid versus liquid emptying studies...
  44. Wang H, Tsai C, Hung G, Lin W. Effectiveness of delayed 2-day lymphoscintigraphy on sentinel lymph node detection in patients with breast cancer with negative early lymphoscintigraphy. Clin Nucl Med. 2006;31:523-6 pubmed
    ..In this study, we evaluated the effectiveness of delayed imaging (more than 15 hours) for SLN detection in patients with negative early images...
  45. Zulfikaroglu B, Koc M, Ozmen M, Kucuk N, Ozalp N, Aras G. Intraoperative lymphatic mapping and sentinel lymph node biopsy using radioactive tracer in gastric cancer. Surgery. 2005;138:899-904 pubmed
    ..The current study examines the feasibility and reliability of sentinel lymph node biopsy in gastric cancer...
  46. Diaz L, Hunt K, Ames F, Meric F, Kuerer H, Babiera G, et al. Histologic localization of sentinel lymph node metastases in breast cancer. Am J Surg Pathol. 2003;27:385-9 pubmed
    ..This information may be useful in determining the optimal method for evaluating axillary sentinel lymph node specimens from breast cancer patients...
  47. Iascone C, Di Giulio E, Maffi C, Ruperto M. Use of radioisotopic esophageal transit in the assessment of patients with symptoms of reflux and non-specific esophageal motor disorders. Dis Esophagus. 2004;17:218-22 pubmed
    ..Radioisotopic esophageal clearance abnormalities are frequently observed in patients with reflux symptoms and are more likely to be associated to hypomotility disorders, i.e. nonpropagated motor activity or low-amplitude contractions...
  48. Chen F, Huang J, Lin W, Ting C. Pedal Tc-99m phytate lymphoscintigraphy in primary chylopericardium. Int J Cardiol. 2003;90:341-3 pubmed
    ..This was the first reported case of primary chylopericardium diagnosed with Tc-99m phytate lymphoscintigraphy...
  49. Diez M, Canela T, Villas A, Gil M. [Contribution of (99m)Tc-mebrofenin scintigraphy to the diagnosis of ectopic liver. A case report]. Rev Esp Med Nucl. 2009;28:125-7 pubmed
    ..We present the case of a woman with a parasplenic mass who underwent abdominal ultrasounds, computed tomography and magnetic resonance imaging. The liver scintigraphy with (99m)Tc-Mebrofenin confirmed the diagnosis of ectopic liver...
  50. Matrai Z, Toth L, Saeki T, Sinkovics I, Godény M, Takeuchi H, et al. [The potential role of SPECT/CT in the preoperative detection of sentinel lymph nodes in breast cancer]. Orv Hetil. 2011;152:678-88 pubmed publisher
    ..It is concluded that 3D SPECT/CT increases the success rate and quality of preoperative sentinel node identification, and is capable of providing a more accurate staging of breast cancer patients in routine clinical practice...
  51. Buchholz V, Berkenstadt H, Goitein D, Dickman R, Bernstine H, Rubin M. Gastric emptying is not prolonged in obese patients. Surg Obes Relat Dis. 2013;9:714-7 pubmed publisher
    ..with contradicting reports stating shorter, similar, and longer times compared with nonobese subjects. The aim of the present study was to compare gastric emptying in obese and nonobese subjects at a university hospital...
  52. Shaw D, Williams R, Cook I, Wallace K, Weltman M, Collins P, et al. Oropharyngeal scintigraphy: a reliable technique for the quantitative evaluation of oral-pharyngeal swallowing. Dysphagia. 2004;19:36-42 pubmed
    ..It may prove useful in assessment of dysphagia severity and longitudinal change...
  53. Chew C, Bartholomeusz F, Bellon M, Chatterton B. Simultaneous 13C/14C dual isotope breath test measurement of gastric emptying of solid and liquid in normal subjects and patients: comparison with scintigraphy. Nucl Med Rev Cent East Eur. 2003;6:29-33 pubmed
    ..To develop a simple method for simultaneous solid and liquid gastric emptying assessment using a dual isotope labelled breath test...