unithiol

Summary

Summary: A chelating agent used as an antidote to heavy metal poisoning.

Top Publications

  1. Muran P. Mercury elimination with oral DMPS, DMSA, vitamin C, and glutathione: an observational clinical review. Altern Ther Health Med. 2006;12:70-5 pubmed
    ..This protocol yielded an average 69% reduction of urine mercury by provocation analysis. ..
  2. Aposhian H. Mobilization of mercury and arsenic in humans by sodium 2,3-dimercapto-1-propane sulfonate (DMPS). Environ Health Perspect. 1998;106 Suppl 4:1017-25 pubmed
    ..Because South American animals studied were deficient in arsenite methyltransferase, a hypothesis is presented that arsenite and arsenite methyltransferase may have had a role in the evolution of some South American animals. ..
  3. Bose O Reilly S, Drasch G, Beinhoff C, Maydl S, Vosko M, Roider G, et al. The Mt. Diwata study on the Philippines 2000-treatment of mercury intoxicated inhabitants of a gold mining area with DMPS (2,3-dimercapto-1-propane-sulfonic acid, Dimaval). Sci Total Environ. 2003;307:71-82 pubmed
    ..Adverse side effects were rarely reported. Only in one case the medication had to be terminated after the first application due to an allergic skin reaction...
  4. George G, Prince R, Gailer J, Buttigieg G, Denton M, Harris H, et al. Mercury binding to the chelation therapy agents DMSA and DMPS and the rational design of custom chelators for mercury. Chem Res Toxicol. 2004;17:999-1006 pubmed
    ..We discuss the design criteria for a mercuric specific chelator molecule or "custom chelator", which might form the basis for an improved clinical treatment...
  5. Wilson W, Sander L, Oña Ruales J, Mössner S, Sidisky L, Lee M, et al. Retention behavior of alkyl-substituted polycyclic aromatic sulfur heterocycle isomers in gas chromatography on stationary phases of different selectivity. J Chromatogr A. 2017;1484:73-84 pubmed publisher
    ..Correlation coefficients for retention on the IL phase vs L/B ranged from r=0.13 (MeN12Ts) to r=0.83 (EtDBTs). Correlation coefficients for retention on the 50% LC-DMPS phase vs L/B ranged from r=0.22 (MeDBTs) to r=0.84 (TriMeDBTs). ..
  6. Lungkaphin A, Chatsudthipong V, Evans K, Groves C, Wright S, Dantzler W. Interaction of the metal chelator DMPS with OAT1 and OAT3 in intact isolated rabbit renal proximal tubules. Am J Physiol Renal Physiol. 2004;286:F68-76 pubmed
    ..These data suggest that, whereas both OAT1 and OAT3 probably transport DMPSH, DMPSS transport may be limited to OAT3. This is the first evidence showing that both OAT1 and OAT3 can transport DMPS across the basolateral membrane of RPT. ..
  7. Eyer F, Felgenhauer N, Pfab R, Drasch G, Zilker T. Neither DMPS nor DMSA is effective in quantitative elimination of elemental mercury after intentional IV injection. Clin Toxicol (Phila). 2006;44:395-7 pubmed
    ..Although urinary excretion could be enhanced during chelation therapy, Hg deposits in organs resulted in negligible elimination of mercury compared to the exposed dose. ..
  8. ASTORGA B, Wunz T, Morales M, Wright S, Pelis R. Differences in the substrate binding regions of renal organic anion transporters 1 (OAT1) and 3 (OAT3). Am J Physiol Renal Physiol. 2011;301:F378-86 pubmed publisher
    ..Consistent with their homolog-specific selectivities, these data highlight structural differences in the substrate binding regions of OAT1 and OAT3. ..
  9. Robinson L. Insult to injury. US News World Rep. 2007;142:44-50 pubmed

More Information

Publications107 found, 100 shown here

  1. Xu S, Li X, Zhu H, Liu Y, Fang F, Chen L. Clinical efficacy and safety of chelation treatment with typical penicillamine in cross combination with DMPS repeatedly for Wilson's disease. J Huazhong Univ Sci Technolog Med Sci. 2013;33:743-747 pubmed publisher
  2. Krzyzewska I, Ensink J, Nawijn L, Mul A, Koch S, Venema A, et al. Genetic variant in CACNA1C is associated with PTSD in traumatized police officers. Eur J Hum Genet. 2018;26:247-257 pubmed publisher
    ..Moreover, here we showed that genetically confounded 450K probes are informative for genetic association analysis. ..
  3. Carranza Rosales P, Guzmán Delgado N, Cruz Vega D, Balderas Renteria I, Gandolfi A. DMPS reverts morphologic and mitochondrial damage in OK cells exposed to toxic concentrations of HgCl2. Cell Biol Toxicol. 2007;23:163-76 pubmed
    ..DMPS also showed potent antioxidant activity in vitro. Mitochondrial protection could be the cellular mechanism mediated by DMPS in OK cells exposed to a toxic concentration of HgCl(2). ..
  4. Buchsteiner A, Hauss T, Dante S, Dencher N. Alzheimer's disease amyloid-beta peptide analogue alters the ps-dynamics of phospholipid membranes. Biochim Biophys Acta. 2010;1798:1969-76 pubmed publisher
    ..The amyloid-beta (25-35) peptide induced membrane alteration even at only 3mol% might be involved in the pathology of Alzheimer's disease as well as be a clue in early diagnosis and therapy. ..
  5. Harrison J, Smith T, Fell T, Smith J, Ham G, Haylock R, et al. Collateral contamination concomitant to the polonium-210 poisoning of Mr Alexander Litvinenko. J Radiol Prot. 2017;37:837-851 pubmed publisher
    ..The use of the chelating agent, unithiol, to increase 210Po excretion in this case was only moderately effective in reducing doses received.
  6. Aposhian H, Zheng B, Aposhian M, Le X, Cebrian M, Cullen W, et al. DMPS-arsenic challenge test. II. Modulation of arsenic species, including monomethylarsonous acid (MMA(III)), excreted in human urine. Toxicol Appl Pharmacol. 2000;165:74-83 pubmed
  7. Andersen O, Aaseth J. A review of pitfalls and progress in chelation treatment of metal poisonings. J Trace Elem Med Biol. 2016;38:74-80 pubmed publisher
    ..Solid knowledge on the chemistry of metal chelates together with relevant animal experiments should guide development of chelation procedures to alleviate and not aggravate the clinical status of poisoned patients. ..
  8. Wee J, Day D, Linz J. Effects of Zinc Chelators on Aflatoxin Production in Aspergillus parasiticus. Toxins (Basel). 2016;8: pubmed publisher
    ..From an application perspective, these data provide the basis for biological differences that exist in the efficacy of different zinc chelators in various food and feed crops frequently contaminated by aflatoxin. ..
  9. Cole M, Quach H, Quach D, Baker A, Taylor K, Barcellos L, et al. Epigenetic Signatures of Salivary Gland Inflammation in Sjögren's Syndrome. Arthritis Rheumatol. 2016;68:2936-2944 pubmed publisher
    ..Methylation profiling implicated several genes and pathways previously thought to be involved in disease-related processes, as well as a number of new candidates. ..
  10. Nogueira C, Soares F, Nascimento P, Muller D, Rocha J. 2,3-Dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid increase mercury- and cadmium-induced inhibition of delta-aminolevulinate dehydratase. Toxicology. 2003;184:85-95 pubmed
    ..The mechanism of hepatic delta-ALA-D inhibition by Hg(2+)-DMPS/DMSA and Cd(2+)-DMPS/DMSA complexes involve the essential thiol groups of the enzyme. ..
  11. Eckstein M. Prehospital 12-lead speeds care. JEMS. 2005;30:38, 40-1 pubmed
  12. Bozorgmehr K, Maier W, Brenner H, Saum K, Stock C, Miksch A, et al. Social disparities in Disease Management Programmes for coronary heart disease in Germany: a cross-classified multilevel analysis. J Epidemiol Community Health. 2015;69:1091-101 pubmed publisher
    ..Future studies on DMPs should consider contextual effects when analysing programme effectiveness or impacts on equity and efficiency. ..
  13. Manrique Moreno M, Heinbockel L, Suwalsky M, Garidel P, Brandenburg K. Biophysical study of the non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with phosphatidylserine bilayer membranes. Biochim Biophys Acta. 2016;1858:2123-2131 pubmed publisher
    ..The data show that the NSAID react in a particular way with this lipid, but in some parameters the three NSAID clearly differ, with which now a clear picture of the interaction processes is possible. ..
  14. Rai D, Qian S, Heller W. The Interaction of Melittin with Dimyristoyl Phosphatidylcholine-Dimyristoyl Phosphatidylserine Lipid Bilayer Membranes. Biochim Biophys Acta. 2016;1858:2788-2794 pubmed publisher
    ..The results provide new information about lipid-specific interactions that take place in mixed composition lipid bilayer membranes. ..
  15. Requejo R, Tena M. Influence of glutathione chemical effectors in the response of maize to arsenic exposure. J Plant Physiol. 2012;169:649-56 pubmed publisher
    ..5- and 4.0-fold by DMS and DMPS. Therefore, tolerance and accumulation of arsenic by maize could be manipulated pharmacologically by chemical effectors of GSH. ..
  16. Aldhaheri S, Jeelani R, Kohan Ghadr H, Khan S, Mikhael S, Washington C, et al. Dimercapto-1-propanesulfonic acid (DMPS) induces metaphase II mouse oocyte deterioration. Free Radic Biol Med. 2017;112:445-451 pubmed publisher
  17. Pingree S, Simmonds P, Rummel K, Woods J. Quantitative evaluation of urinary porphyrins as a measure of kidney mercury content and mercury body burden during prolonged methylmercury exposure in rats. Toxicol Sci. 2001;61:234-40 pubmed
    ..These findings demonstrate that urinary porphyrin concentrations relate quantitatively to DMPS-mobilizable mercury in the kidney and, therefore, serve as a biochemical measure of renal mercury content. ..
  18. Aposhian H, Aposhian M. Arsenic toxicology: five questions. Chem Res Toxicol. 2006;19:1-15 pubmed
  19. Liu W, Jiang C, Hu Z, Zhang C, Xu Q, Zhou G. [Mercury concentration in cerebrospinal fluid in patients with chronic mercury poisoning]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006;24:403-5 pubmed
    ..It indicates that mercury is combined with protein after entering brain and this complex is difficult to cross through blood-cerebral barrier. The complex may cause neuromuscular disorder and fremitus in chronic mercury poisoning. ..
  20. Tian Y, Gong G, Yang X. [Prognosis and treatment of fulminant Wilson's disease]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011;36:1111-4 pubmed publisher
    ..The level of hepatic failure and the occurrence of infection are the decisive factors for prognosis of patients with FWD. PE with decoppering treatment and corticosteroid administration are effective. ..
  21. Lu Y, Xia X, Sui S. The interaction of trichosanthin with supported phospholipid membranes studied by surface plasmon resonance. Biochim Biophys Acta. 2001;1512:308-16 pubmed
    ..It is proposed that, besides electrostatic forces, hydrophobic interaction may also be involved in the binding process. ..
  22. Brandão R, Borges L, Nogueira C. Concomitant administration of sodium 2,3-dimercapto-1-propanesulphonate (DMPS) and diphenyl diselenide reduces effectiveness of DMPS in restoring damage induced by mercuric chloride in mice. Food Chem Toxicol. 2009;47:1771-8 pubmed publisher
    ..Combined therapy with (PhSe)(2) and DMPS was less effective than isolated therapies in restoring the damage induced by HgCl(2) in mice...
  23. Chan T. Inorganic mercury poisoning associated with skin-lightening cosmetic products. Clin Toxicol (Phila). 2011;49:886-91 pubmed publisher
    ..Mercury and mercury salts, including mercurous chloride and mercurous oxide, are prohibited for use in cosmetic products as skin-lightening agents because of their high toxicity. Yet, the public continue to have access to these products...
  24. Cohen J, Ruha A, Curry S, Biswas K, Westenberger B, Ye W, et al. Plasma and urine dimercaptopropanesulfonate concentrations after dermal application of transdermal DMPS (TD-DMPS). J Med Toxicol. 2013;9:9-15 pubmed publisher
    ..These results indicate that TD-DMPS is not absorbed. There was no increase in urine mercury excretion after TD-DMPS. Our results argue that TD-DMPS is an ineffective metal chelator. ..
  25. Fernando F, Keijser R, Henneman P, van der Kevie Kersemaekers A, Mannens M, van der Post J, et al. The idiopathic preterm delivery methylation profile in umbilical cord blood DNA. BMC Genomics. 2015;16:736 pubmed publisher
    ..A DMP on MYL4, encoding myosin light chain 4, is a robust candidate for the identification of idiopathic preterm labour as it is identified by all 3 independent studies. ..
  26. Shafer T. Effects of Cd2+, Pb2+ and CH3Hg+ on high voltage-activated calcium currents in pheochromocytoma (PC12) cells: potency, reversibility, interactions with extracellular Ca2+ and mechanisms of block. Toxicol Lett. 1998;99:207-21 pubmed
    ..These results characterize effects of Cd2+ on Ca2+ channels and demonstrate that Cd2+, Pb2+ and CH3Hg+ differ in their actions on Ca2+ channels. ..
  27. Bondarenko G, Zenovich S. [Study on interaction of acetaldehyde with thioalcohols by infrared spectroscopy]. Biomed Khim. 2007;53:729-35 pubmed
    The reaction of acetaldehyde with thioalcohols, Mesna (monothiol) and Unithiol (vicinal dithiol) was investigated by infrared spectroscopy. Unithiol was more active in the reaction of acetaldehyde fixation than Mesna...
  28. Pedersen U, Peters G, Schrøder T, Dyre J. Correlated volume-energy fluctuations of phospholipid membranes: a simulation study. J Phys Chem B. 2010;114:2124-30 pubmed publisher
    ..The strong correlations reported here confirm one crucial assumption of a recent theory for nerve signal propagation proposed by Heimburg and Jackson (T. Heimburg and A. D. Jackson, Proc. Natl. Acad. Sci. 2005, 102, 9790-9795). ..
  29. Peternel L, Noda T, Petrič T, Ude A, Morimoto J, Babič J. Adaptive Control of Exoskeleton Robots for Periodic Assistive Behaviours Based on EMG Feedback Minimisation. PLoS ONE. 2016;11:e0148942 pubmed publisher
    ..We further evaluated the proposed approach on a whole-arm exoskeleton to show that it is able to adaptively derive assistive torques even for multiple-joint motion. ..
  30. Lockhart C, Klimov D. The Alzheimer's disease Aβ peptide binds to the anionic DMPS lipid bilayer. Biochim Biophys Acta. 2016;1858:1118-28 pubmed publisher
    ..6) Aβ binding disorders proximal DMPS lipids more strongly than their DMPC counterparts. Our simulations show that Aβ monomers fail to perturb anionic or zwitterionic bilayers across both leaflets. ..
  31. Williams M, Bagwell J, Nahm Zozus M. Data management plans: the missing perspective. J Biomed Inform. 2017;71:130-142 pubmed publisher
  32. Sun P, Han J, Weng Y. The antidotal effects of high-dosage gamma-aminobutyric acid on acute tetramine poisoning as compared with sodium dimercaptopropane sulfonate. J Huazhong Univ Sci Technolog Med Sci. 2007;27:419-21 pubmed
    ..And it is suggested that high-dosage GABA may be used as an excellent antidote for acute TET poisoning in clinical practice. The indications and correct dosage for clinical use awaits to be further studied. ..
  33. Truong L, Moody I, Stankus D, Nason J, Lonergan M, Tanguay R. Differential stability of lead sulfide nanoparticles influences biological responses in embryonic zebrafish. Arch Toxicol. 2011;85:787-98 pubmed publisher
    ..These studies demonstrate that in vivo assessments can be effectively used to characterize the role of NP surface functionalization in predicting biological responses. ..
  34. Gombos B, Merva M, Sekula F, Koci M. Phenylmercury and its mobilization in the organism by a metal complex-forming substance: 2,3-dimercapto-1-propane sodium sulfonate. Med Lav. 1996;87:297-304 pubmed
    ..Most probably, it was a case of interpotentiation of the effects of toxic and non-toxic nature. ..
  35. Yajima Y, Kawaguchi M, Yoshikawa M, Okubo M, Tsukagoshi E, Sato K, et al. The effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA) on the nephrotoxicity in the mouse during repeated cisplatin (CDDP) treatments. J Pharmacol Sci. 2017;134:108-115 pubmed publisher
  36. Zhang Y, Fukui N, Yahata M, Katsuragawa Y, Tashiro T, Ikegawa S, et al. Genome-wide DNA methylation profile implicates potential cartilage regeneration at the late stage of knee osteoarthritis. Osteoarthritis Cartilage. 2016;24:835-43 pubmed publisher
    ..Pathways and networks enriched in identified DM genes highlighted potential etiologic mechanism and implicated the potential cartilage regeneration in the late stage of knee OA. ..
  37. Jo B, Koh I, Bae J, Yu H, Jeon E, Lee H, et al. Methylome analysis reveals alterations in DNA methylation in the regulatory regions of left ventricle development genes in human dilated cardiomyopathy. Genomics. 2016;108:84-92 pubmed publisher
    ..Alterations in DNA methylation were specifically enriched in the cis-regulatory regions of cardiac development genes, the majority of which are involved in ventricular development (e.g., TBX5 and HAND1). ..
  38. Bjørklund G, Mutter J, Aaseth J. Metal chelators and neurotoxicity: lead, mercury, and arsenic. Arch Toxicol. 2017;91:3787-3797 pubmed publisher
    ..However, new insight indicates that a combination of low-dosed BAL plus DMPS could be a preferred antidotal therapy to obtain mobilization of the intracerebral deposits into the circulation for subsequent rapid urinary excretion. ..
  39. Santos F, Zeni G, Rocha J, do Nascimento P, Marques M, Nogueira C. Efficacy of 2,3-dimercapto-1-propanesulfonic acid (DMPS) and diphenyl diselenide on cadmium induced testicular damage in mice. Food Chem Toxicol. 2005;43:1723-30 pubmed
    ..The use of combined therapy (DMPS plus (PhSe)2) proved to be efficient in decreasing cadmium levels in testes and in ameliorating plasma AST activity from animals that received the highest dose of cadmium. ..
  40. Zhang C, Zhu T, Hu G, Chen X, Liu D, Chen Z. Effect of sodium dimercaptopropanesulfonate on antagonism of tetramethylenedisulphotetramine to GABA receptor. Acta Pharmacol Sin. 2001;22:435-9 pubmed
    ..109 +/- 0.005), (0.128 +/- 0.007), and (0.125 +/- 0.008), respectively]. The inhibitory effects of DMPS on the antagonism of TETS to GABA receptor are due to the increase in the GABA binding to its receptors in brain caused by DMPS ..
  41. Høl P, Vamnes J, Gjerdet N, Eide R, Isrenn R. Copper, zinc, and selenium in human blood and urine after injection of sodium 2,3-dimercaptopropane-1-sulfonate: a study on subjects with dental amalgam. Biol Trace Elem Res. 2003;91:19-31 pubmed
    ..Administration of a single dose of DMPS does not affect the body stores of the essential elements Cu, Zn, and Se. ..
  42. Juresa D, Blanusa M, Kostial K. Simultaneous administration of sodium selenite and mercuric chloride decreases efficacy of DMSA and DMPS in mercury elimination in rats. Toxicol Lett. 2005;155:97-102 pubmed
    ..It is concluded that sodium selenite decreases the efficiency of DMSA and DMPS in mercury removal from the body of rats. ..
  43. Van der Linde A, Lewiszong Rutjens C, Verrips A, Gerrits G. A previously healthy 11-year-old girl with behavioural disturbances, desquamation of the skin and loss of teeth. Eur J Pediatr. 2009;168:509-11 pubmed publisher
    ..Chest X-ray, brain CAT and MRI scan were all normal. Lumbar puncture didn't show any abnormalities. Eventually a 24-hour urine test confirmed the diagnosis that was suspected by further questioning. ..
  44. Ho G, Keutgens A, Schoofs R, Kotolenko S, Denooz R, Charlier C. Blood, urine, and hair kinetic analysis following an acute lead intoxication. J Anal Toxicol. 2011;35:60-4 pubmed
    ..Numerous blood and urine samples were collected for kinetic analysis of lead elimination. However, we report the first case in which hair samples were analyzed to determine the excretion level of lead after acute intoxication. ..
  45. Wang Y, Zalups R, Barfuss D. Luminal transport of thiol S-conjugates of methylmercury in isolated perfused rabbit renal proximal tubules. Toxicol Lett. 2012;213:203-10 pubmed publisher
    ..By contrast NAC-S-CH(3)Hg and Cys-S-CH(3)Hg (in the presence of DMPS) are not taken up avidly at the luminal membrane of proximal tubular cells, thus promoting the excretion of CH(3)Hg(+) into the urine. ..
  46. Cavanillas S, Chekmeneva E, Arino C, Díaz Cruz J, Esteban M. Electroanalytical and isothermal calorimetric study of As(III) complexation by the metal poisoning remediators, 2,3-dimercapto-1-propanesulfonate and meso-2,3-dimercaptosuccinic acid. Anal Chim Acta. 2012;746:47-52 pubmed publisher
    ..2 and 9.8, respectively. These values confirm the potential efficiency of both ligands in the treatment of As(III) poisoning. ..
  47. Harvie P, Wong F, Bally M. Characterization of lipid DNA interactions. I. Destabilization of bound lipids and DNA dissociation. Biophys J. 1998;75:1040-51 pubmed
    ..These results are interpreted in terms of factors that regulate the disassembly of lipid-based DNA formulations. ..
  48. Qiu Z, Lan H, Zhang S, Xia Y, Huang S. [Antidotal effects of vitamin B(6) and sodium dimercaptopropane sulfonate on acute poisoning with tetramethylene disulphotetramine in animals]. Zhonghua Nei Ke Za Zhi. 2002;41:186-8 pubmed
    ..Vit B(6) with Na-DMPS is an excellent antidote for acute TETS poisoning. It is suggested that Vit B(6) with Na-DMPS may be clinically used to rescue patients poisoned by TETS. ..
  49. Nogueira C, Santos F, Soares F, Rocha J. 2,3-Dimercaptopropanol, 2,3-dimercaptopropane-1-sulfonic acid, and meso-2,3-dimercaptosuccinic acid inhibit delta-aminolevulinate dehydratase from human erythrocytes in vitro. Environ Res. 2004;94:254-61 pubmed
    ..ZnCl(2) (1 microM) added, in the reaction mixture, increased enzyme activity and DTT (100 microM) totally restored the enzyme activity for all chelating agents tested. ..
  50. Troshichev O, Gorshkov E, Shapovalov S, Sokolovskii V, Ivanov V, Vorobeitchikov V. Variations of the gravitational field as a motive power for rhythmics of biochemical processes. Adv Space Res. 2004;34:1619-24 pubmed
    ..The following of them are examined as examples: the rate of the unithiol oxidation in vitro, concentration of the thiol compounds in human urine, some hematological indicators (rate of ..
  51. Sinkovic A, Strdin A, Svensek F. Severe acute copper sulphate poisoning: a case report. Arh Hig Rada Toksikol. 2008;59:31-5 pubmed publisher
    ..In addition, antidotes such as methylene blue for methaemoglobinaemia and chelating agent such as DMPS improve morbidity and survival of severely poisoned victims. ..
  52. Nemeti B, Gregus Z. Mechanism of thiol-supported arsenate reduction mediated by phosphorolytic-arsenolytic enzymes: I. The role of arsenolysis. Toxicol Sci. 2009;110:270-81 pubmed publisher
    ..This hypothesis is evaluated in the adjoining paper. ..
  53. He X, Zhao G, Lu Z, Hong G, He F, Liang H, et al. [Oxidative stress of acute paraquat poisoned rats and sodium dimercaptopropane sulfonate intervention]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2009;27:476-9 pubmed
    ..01). Na-DMPS decreases the activity of MDA and increases the activity of CAT, GSH and the expression of Nrf2 mRNA. NA-DMPS can protected rats from PQ intoxication by improving the balance of redox reaction. ..
  54. Essex D, Li M. Redox control of platelet aggregation. Biochemistry. 2003;42:129-36 pubmed
  55. Bridges C, Joshee L, Zalups R. MRP2 and the DMPS- and DMSA-mediated elimination of mercury in TR(-) and control rats exposed to thiol S-conjugates of inorganic mercury. Toxicol Sci. 2008;105:211-20 pubmed publisher
    ..Overall, these data support our hypothesis that Mrp2 is involved in the DMPS and DMSA-mediated extraction of the body burden of Hg2+...
  56. Bernhoft R. Mercury toxicity and treatment: a review of the literature. J Environ Public Health. 2012;2012:460508 pubmed publisher
    ..Mercury is capable of inducing a wide range of clinical presentations. Diagnosis of mercury toxicity can be challenging but can be obtained with reasonable reliability. Effective therapies for clinical toxicity have been described. ..
  57. Grachev S, Sverdlov A, Nikanorova N, Timoshenko S. [Increased efficacy of radiation protection against fission neutrons using unithiol]. Radiats Biol Radioecol. 1999;39:258-60 pubmed
    It was found that the combination of unithiol (Sodium salt of 2,3-dimercapto-1-propansulfonic acid) with cystamine and AET diminished their toxicity. The optimum ratio for the antitoxic effect is 0...
  58. Tsvetkova N, Horvath I, Torok Z, Wolkers W, Balogi Z, Shigapova N, et al. Small heat-shock proteins regulate membrane lipid polymorphism. Proc Natl Acad Sci U S A. 2002;99:13504-9 pubmed
    ..We infer from these results that the association between sHsps and membranes may constitute a general mechanism that preserves membrane integrity during thermal fluctuations. ..
  59. Wang X, Yang R, Ren M, Sun B. Anticopper efficacy of captopril and sodium dimercaptosulphonate in patients with Wilson's disease. Funct Neurol. 2003;18:149-53 pubmed
    ..The authors also discuss recent experience of the overall treatment in China. ..
  60. Chen Z, Lu Z. Sodium dimercaptopropane sulfonate as antidote against non-metallic pesticides. Acta Pharmacol Sin. 2004;25:534-44 pubmed
  61. Xue B, Yang R, Hu J. [Effect of Gandou Decoction IV combined with short-term decoppering therapy with sodium dimercapto-sulphonate on serum indexes of hepatic fibrosis in patients with Wilson' s disease]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27:785-8 pubmed
  62. Zalups R, Bridges C. MRP2 involvement in renal proximal tubular elimination of methylmercury mediated by DMPS or DMSA. Toxicol Appl Pharmacol. 2009;235:10-7 pubmed publisher
    ..Overall, these dispositional findings indicate that MRP2 does play a role in DMPS- and DMSA-mediated elimination of mercury from the kidney...
  63. Barrett M, Trapp M, Lohstroh W, Seydel T, Ollivier J, Ballauff M, et al. Alzheimer's peptide amyloid-β, fragment 22-40, perturbs lipid dynamics. Soft Matter. 2016;12:1444-51 pubmed publisher
    ..The effect of the amyloid-β peptide fragment on the diffusion of membrane lipids will provide insight into the membrane's role in AD. ..
  64. Wan W, Xu M, Zou H, Lu A, Shen X, Chen Y. [The activity of blood cholinesterase in rats exposed to dimethypo after drug intervention]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2002;20:419-21 pubmed
    ..To investigate the activity of ChE in rats poisoned by dimehypo and then treated with pralidoxime methylchloride or unithiol. Rats were divided into control group (dimehypo); intervention groups [dimehypo plus pralidoxime methylchloride ..
  65. Zhao C, Lu Z, Li H, Li J. [Treatment with diazepanum and dimercaptopropansulfonate sodium for acute tetramine intoxication]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2004;22:68-9 pubmed
  66. Kenar L, Karayilanoglu T, Yuksel A, Gunhan O, Kose S, Kurt B. Evaluation of protective ointments used against dermal effects of nitrogen mustard, a vesicant warfare agent. Mil Med. 2005;170:1-6 pubmed
  67. Luchese C, Zeni G, Rocha J, Nogueira C, Santos F. Cadmium inhibits delta-aminolevulinate dehydratase from rat lung in vitro: interaction with chelating and antioxidant agents. Chem Biol Interact. 2007;165:127-37 pubmed
    ..In contrast, these compounds potentiated the inhibition induced by Cd(2+) in rat lung. ..
  68. Drasch G, Boese O Reilly S, Illig S. Increase of renal excretion of organo-mercury compounds like methlymercury by DMPS (2,3-Dimercapto-1-propanesulfonic acid, Dimaval). Clin Toxicol (Phila). 2007;45:266-9 pubmed
    ..1 for organic Hg. There was a trend that females responded better to DMPS than males. It was concluded that DMPS increases the renal excretion of organic bound Hg as it does for inorganic Hg, but to a lesser extent. ..
  69. Flora S, Flora G, Saxena G, Mishra M. Arsenic and lead induced free radical generation and their reversibility following chelation. Cell Mol Biol (Noisy-le-grand). 2007;53:26-47 pubmed
    ..A number of other strategies have been suggested to minimize the numerous problems. This article presents the recent development made in this area with possible directions for future research. ..
  70. Van der Linde A, Pillen S, Gerrits G, Bouwes Bavinck J. Stevens-Johnson syndrome in a child with chronic mercury exposure and 2,3-dimercaptopropane-1-sulfonate (DMPS) therapy. Clin Toxicol (Phila). 2008;46:479-81 pubmed publisher
    ..The reported association suggests that SJS may be a potential complication of DMPS therapy, and this should be considered in the risk-benefit analysis of chelation. ..
  71. Eing A, Janshoff A, Galla H, Block C, Steinem C. Quantification of the Raf-C1 interaction with solid-supported bilayers. Chembiochem. 2002;3:190-7 pubmed
    ..We hypothesize that PS-enriched domains are initial binding sites with high affinity for Raf-C1, but that lateral interactions may account for protein domain growth. ..
  72. Richter M, Cantin A, Beaulieu C, Cloutier A, Larivee P. Zinc chelators inhibit eotaxin, RANTES, and MCP-1 production in stimulated human airway epithelium and fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2003;285:L719-29 pubmed
    ..Together these results demonstrate that modulation of the labile pool of zinc can regulate gene expression and protein synthesis of C-C chemokines in lung epithelial cells and fibroblasts. ..
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    ..We feel that CVVHDF should be considered in patients with inorganic mercury poisoning, particularly those who develop acute renal failure, together with meticulous supportive care and adequate doses of chelation therapy with DMPS. ..
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    ..In conclusion, therapies with (PhSe)2, DMPS and NAC following mercury exposure must be better studied because the formation of more toxic complexes with mercury, which can mainly damage renal tissue. ..
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    ..The potentiation of Fe-citrate toxicity is of concern because of iron's role in oxidative stress in the body. Potentiation of iron toxicity could have serious health consequences when using chelation therapy. ..
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    ..In support of this view, reactivity studies using conceptual density functional theory reactivity descriptors (local softness, nucleofugality) indicate that reduction by thiols of the arsenylated metabolites is favored over AsV...
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    ..On the basis of the substantial interaction of OAT3 with DMPSS, we conclude that OAT3 represents the dominant basolateral player in renal detoxification processes resulting from use of DMPS. ..
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    ..In addition, the cytotoxicity of A?(1-42) peptides on the SH-SY5Y cells decreased after the treatment with HL-DMPS. These results suggest that anionic HL-DMPS could be used as a novel medicine for AD in the future. ..
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    ..Thus, our results show that both silver nanoparticles and silver ions have potential to disrupt basic metabolic functions and enzymatic resource acquisition of stream periphyton. ..
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    ..This interaction may be the fundamental process behind cross-β sheet formation in membranes and these sheets may serve as seeds for further growth into amyloid fibrils. ..
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    ..This study thus provides a more-detailed glimpse into the context-dependent interaction dynamics and importance of the ?-sheets in Fyn-SH3 and proline-rich region of MBP. Proteins 2017; 85:1336-1350. © 2017 Wiley Periodicals, Inc. ..
  82. Buchet J, Lauwerys R. Influence of 2,3-dimercaptopropane-1-sulfonate and dimercaptosuccinic acid on the mobilization of mercury from tissues of rats pretreated with mercuric chloride, phenylmercury acetate or mercury vapors. Toxicology. 1989;54:323-33 pubmed
    ..The loss of mercury from the liver can be slightly accelerated by repeated administration of the chelators. However, the chelators are inefficient in removing mercury from the brain. ..
  83. Kehe K, Flohe S, Krebs G, Kreppel H, Reichl F, Liebl B, et al. Effects of Lewisite on cell membrane integrity and energy metabolism in human keratinocytes and SCL II cells. Toxicology. 2001;163:137-44 pubmed
    ..SCL II cells might be more prone to membrane damage whereas in keratinocytes mitochondrial impairment seems to be the predominant effect of Lewisite. ..
  84. Falnoga I, Kobal A, Stibilj V, Horvat M. Selenoprotein P in subjects exposed to mercury and other stress situations such as physical load or metal chelation treatment. Biol Trace Elem Res. 2002;89:25-33 pubmed
    ..The decrease of Se bound on Sel-P was accompanied by its increase in fraction of pGSH-Px with albumin. ..
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    ..A standardised procedure for evaluation of the magnitude and origin of the Hg burden of individuals has been developed, which, by comparison with the database presented here for the first time, can serve as a diagnostic tool. ..
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    ..Cross-reactivity of DMPS to other chelators like D-penicillamine is possible; the indications for chelation therapy should be weighed carefully. ..
  87. Gong Z, Jiang G, Cullen W, Aposhian H, Le X. Determination of arsenic metabolic complex excreted in human urine after administration of sodium 2,3-dimercapto-1-propane sulfonate. Chem Res Toxicol. 2002;15:1318-23 pubmed
    ..Because MMA(III) is the substrate for the biomethylation of arsenic from MMA(V) to DMA(V), the formation of DMPS-MMA(III) complex would reduce the availability of MMA(III) for the subsequent biomethylation. ..
  88. Heinrich Ramm R, Schaller H, Horn J, Angerer J. Arsenic species excretion after dimercaptopropanesulfonic acid (DMPS) treatment of an acute arsenic trioxide poisoning. Arch Toxicol. 2003;77:63-8 pubmed
    ..The high dosage of DMPS is the most likely explanation. The patient left the hospital after a 12-day treatment with antidote. ..
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    ..Our results extend the 2-fold rotational symmetry from the ligand binding domain to at minimum the extracellular part of the channel and suggest a model of gating movements in GluR pore-forming domains. ..
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    ..Based on this result and differences in the kinetics of integrin activation, we conclude that conformational activation of VLA-4 by inside-out signaling is independent of and additive to reduction-regulated integrin activation. ..
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    ..It would also appear that although not needed for structural stabilization anionic lipid was required for membrane penetration. ..
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