amifostine

Summary

Summary: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.

Top Publications

  1. Leong S, Tan E, Fong K, Wilder Smith E, Ong Y, Tai B, et al. Randomized double-blind trial of combined modality treatment with or without amifostine in unresectable stage III non-small-cell lung cancer. J Clin Oncol. 2003;21:1767-74 pubmed
    ..This study was designed to determine if the use of amifostine could reduce treatment-related toxicities associated with the use of paclitaxel plus carboplatin and thoracic ..
  2. Rades D, Fehlauer F, Bajrovic A, Mahlmann B, Richter E, Alberti W. Serious adverse effects of amifostine during radiotherapy in head and neck cancer patients. Radiother Oncol. 2004;70:261-4 pubmed
    b>Amifostine has been shown to protect against xerostomia induced by radiotherapy for head and neck cancer, but its impact on the therapeutic index is unknown...
  3. Vorgias G, Profitis E, Sarris G, Strigou S, Kosmas C, Katsoulis M, et al. Evaluation of the possible benefits of post-radiotherapy surgery after concomitant chemoradiotherapy with a new radio-sensitizing regimen (irinotecan / CPT-11, interferon A2b and amifostine) for advanced-stage cervical carcinoma. Preliminary results . J BUON. 2009;14:197-202 pubmed
    ..RT) combined with radiosensitizing chemoimmunotherapy with irinotecan (CPT-11), interferon (IFN) A2b, and amifostine. The last selection (surgery or follow-up) was based on clinical evaluation (downstaged or not)...
  4. Anne P, Machtay M, Rosenthal D, Brizel D, Morrison W, Irwin D, et al. A Phase II trial of subcutaneous amifostine and radiation therapy in patients with head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2007;67:445-52 pubmed
    Intravenous amifostine 200 mg/m2 reduces xerostomia in head-and-neck cancer patients. This Phase II study evaluated subcutaneous (s.c.) amifostine in a similar patient population...
  5. Tsujino I, Miyagi K, Sampson R, Sieber F. Potentiation of the antitumor effect of Merocyanine 540-mediated photodynamic therapy by amifostine and amphotericin B. Photochem Photobiol. 2006;82:458-65 pubmed
    ..We report here that noncytotoxic concentrations of amifostine (Ethyol, Ethiofos, WR-2721) and amphotericin B used either alone or in combination potentiate the MC540-..
  6. Mwale F, Ciobanu I, Demers C, Antoniou J, Heon S, Servant N, et al. Amifostine and dexrazoxane enhance the rapid loss of bone mass and further deterioration of vertebrae architecture in female rats. Calcif Tissue Int. 2005;77:175-9 pubmed
    ..Dexrazoxane (DXR) is an iron-binding compound and the only approved cardioprotectant for use with DOX. Amifostine (AMF) is a free radical scavenger and approved as a broad-spectrum cytoprotectant...
  7. Pauwels B, Korst A, De Pooter C, Lambrechts H, Pattyn G, Lardon F, et al. The radiosensitising effect of gemcitabine and the influence of the rescue agent amifostine in vitro. Eur J Cancer. 2003;39:838-46 pubmed
    ..of different concentrations of gemcitabine and the combination of gemcitabine/radiotherapy with the rescue agent amifostine was investigated in different human tumour cell lines...
  8. Ozsahin M, Betz M, Matzinger O, Bron L, Luthi F, Pasche P, et al. Feasibility and efficacy of subcutaneous amifostine therapy in patients with head and neck cancer treated with curative accelerated concomitant-boost radiation therapy. Arch Otolaryngol Head Neck Surg. 2006;132:141-5 pubmed
    To assess the feasibility and efficacy of subcutaneous amifostine therapy in patients with head and neck cancer treated with curative accelerated radiotherapy (RT). Retrospective study. University of Lausanne, Lausanne, Switzerland...
  9. Kouvaris J, Kouloulias V, Malas E, Antypas C, Kokakis J, Michopoulos S, et al. Amifostine as radioprotective agent for the rectal mucosa during irradiation of pelvic tumors. A phase II randomized study using various toxicity scales and rectosigmoidoscopy. Strahlenther Onkol. 2003;179:167-74 pubmed
    To evaluate the cytoprotective effect of amifostine against radiation-induced acute toxicity to the rectal mucosa...

More Information

Publications62

  1. Dai D, Holmes A, Nguyen T, Davies S, Theele D, Verschraegen C, et al. A potential synergistic anticancer effect of paclitaxel and amifostine on endometrial cancer. Cancer Res. 2005;65:9517-24 pubmed
    ..b>Amifostine protection of normal tissues against the side effects of chemotherapeutic agents has been clinically proven in ..
  2. Rosenthal D, Chambers M, Weber R, Eisbruch A. A phase II study to assess the efficacy of amifostine for submandibular/sublingual salivary sparing during the treatment of head and neck cancer with intensity modulated radiation therapy for parotid salivary sparing. Semin Oncol. 2004;31:25-8 pubmed
    ..Cytoprotection with amifostine (Ethyol; Medimmune Inc, Gaithersburg, MD) has been shown to decrease rates of acute and late xerostomia in ..
  3. Fisher M, Lange B, Needle M, Janss A, Shu H, Adamson P, et al. Amifostine for children with medulloblastoma treated with cisplatin-based chemotherapy. Pediatr Blood Cancer. 2004;43:780-4 pubmed
    In adult patients, amifostine appears to ameliorate cisplatin-related nephrotoxicity and ototoxicity...
  4. Thorstad W, Haughey B, Chao K. Pilot study of subcutaneous amifostine in patients undergoing postoperative intensity modulated radiation therapy for head and neck cancer: preliminary data. Semin Oncol. 2003;30:96-100 pubmed
    ..of unstimulated and stimulated salivary flow rates 6 months after intensity modulated radiation therapy plus amifostine (Ethyol; MedImmune, Inc, Gaithersburg, MD) (study patients) with those obtained in historical controls treated ..
  5. Sastry J, Kellie S. Severe neurotoxicity, ototoxicity and nephrotoxicity following high-dose cisplatin and amifostine. Pediatr Hematol Oncol. 2005;22:441-5 pubmed
    ..b>Amifostine, a broad-spectrum cytoprotector of normal tissues, has been approved by U.S...
  6. Rudat V, Münter M, Rades D, Grötz K, Bajrovic A, Haberkorn U, et al. The effect of amifostine or IMRT to preserve the parotid function after radiotherapy of the head and neck region measured by quantitative salivary gland scintigraphy. Radiother Oncol. 2008;89:71-80 pubmed publisher
    ..to preserve the parotid function after radiotherapy (RT) were compared: application of the radioprotective agent amifostine during RT and parotid-sparing intensity-modulated radiotherapy (IMRT)...
  7. Nicolatou Galitis O, Sotiropoulou Lontou A, Velegraki A, Pissakas G, Kolitsi G, Kyprianou K, et al. Oral candidiasis in head and neck cancer patients receiving radiotherapy with amifostine cytoprotection. Oral Oncol. 2003;39:397-401 pubmed
    ..candidiasis, a xerostomia-related complication, in head and neck cancer patients receiving radiotherapy, with amifostine cytoprotection. Thirty-eight patients received 500 mg amifostine i.v...
  8. Anfossi G, Russo I, Massucco P, Mattiello L, Trovati M. Platelet resistance to the antiaggregating effect of N-acetyl-L-cysteine in obese, insulin-resistant subjects. Thromb Res. 2003;110:39-46 pubmed
    ..thiol that increases availability of endogenous nitric oxide (NO)-and of superoxide dismutase (SOD) and amifostine which act as scavengers of superoxide anion. In platelets from obese subjects (n=20, body mass index [BMI]=34...
  9. Patlakas G, Bouros D, Tsantekidou Pozova S, Koukourakis M. Triplet chemotherapy with docetaxel, gemcitabine and liposomal doxorubicin, supported with subcutaneous amifostine and hemopoietic growth factors, in advanced non-small cell lung cancer. Anticancer Res. 2005;25:1427-31 pubmed
    ..The regimen was supported with amifostine cytoprotection (1000mg injected subcutaneously) and hemopoietic growth factors (rhuG-CSF and rhuEPO) in an ..
  10. Kutta H, Kampen U, Sagowski C, Brenner W, Bohuslavizki K, Paulsen F. Amifostine is a potent radioprotector of salivary glands in radioiodine therapy. Structural and ultrastructural findings. Strahlenther Onkol. 2005;181:237-45 pubmed
    ..This study investigates the radioprotective effects of amifostine in salivary glands of rabbits receiving high-dose radioiodine therapy so as to obtain deeper insight in changes ..
  11. Marcu L. The role of amifostine in the treatment of head and neck cancer with cisplatin-radiotherapy. Eur J Cancer Care (Engl). 2009;18:116-23 pubmed publisher
    ..Therefore, the need for normal tissue protection has arisen. Amifostine is a selective, radio-protective drug used in both radiotherapy and chemotherapy to reduce normal tissue ..
  12. Koukourakis M, Giatromanolaki A, Chong W, Simopoulos C, Polychronidis A, Sivridis E, et al. Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha. Cancer Chemother Pharmacol. 2004;53:8-14 pubmed
    The cytoprotective mechanism of amifostine (WR-2721) implies free radical scavenging and DNA repair activities...
  13. Verstappen C, Postma T, Geldof A, Heimans J. Amifostine protects against chemotherapy-induced neurotoxicity: an in vitro investigation. Anticancer Res. 2004;24:2337-41 pubmed
    ..In this in vitro study, using the rat pheochromocytoma cell line PC-12 neurite-outgrowth assay, the potential of amifostine to protect against cisplatin-, paclitaxel- and vincristine-induced neurotoxicity was investigated Amifostine is ..
  14. Spencer A, Horvath N, Gibson J, Prince H, Herrmann R, Bashford J, et al. Prospective randomised trial of amifostine cytoprotection in myeloma patients undergoing high-dose melphalan conditioned autologous stem cell transplantation. Bone Marrow Transplant. 2005;35:971-7 pubmed
    ..undergoing autologous stem cell transplantation (ASCT) were randomised to receive (n=43) or not receive (n=47) amifostine 910 mg/m(2) prior to melphalan 200 mg/m(2)...
  15. Praetorius N, Mandal T. Alternate delivery route for amifostine as a radio-/chemo-protecting agent. J Pharm Pharmacol. 2008;60:809-15 pubmed publisher
    b>Amifostine (ethiofos, WR-2721) is an organic thiophosphate prodrug that serves as an antineoplastic adjunct and cytoprotective agent useful in cancer chemotherapy and radiotherapy...
  16. Mell L, Movsas B. Pharmacologic normal tissue protection in clinical radiation oncology: focus on amifostine. Expert Opin Drug Metab Toxicol. 2008;4:1341-50 pubmed
    ..b>Amifostine is a cytoprotector that can reduce toxicity and potentially improve the therapeutic ratio of radiotherapy...
  17. Topkan E, Tufan H, Yavuz A, Bacanli D, Onal C, Kosdak S, et al. Comparison of the protective effects of melatonin and amifostine on radiation-induced epiphyseal injury. Int J Radiat Biol. 2008;84:796-802 pubmed publisher
    We compared the effects of amifostine and melatonin in preventing radiation-induced epiphyseal growth plate injury in rats...
  18. Stolarska M, Mlynarski W, Zalewska Szewczyk B, Bodalski J. Cytoprotective effect of amifostine in the treatment of childhood neoplastic diseases--a clinical study including the pharmacoeconomic analysis. Pharmacol Rep. 2006;58:30-4 pubmed
    b>Amifostine is an active aminothiol, which has unique properties as a radio- and chemoprotective agent. It has been reported to prevent myelosuppression and reduce the toxic effects of intensive cancer treatment...
  19. Bolaman Z, Cicek C, Kadikoylu G, Barutca S, Serter M, Yenisey C, et al. The protective effects of amifostine on adriamycin-induced acute cardiotoxicity in rats. Tohoku J Exp Med. 2005;207:249-53 pubmed
    Free oxygen radicals and lipid peroxidation are responsible for adriamycin-induced cardiotoxicity. Amifostine is a scavenger of free radicals and may function as a selective cytoprotective agent...
  20. Kouloulias V, Kouvaris J, Pissakas G, Kokakis J, Antypas C, Mallas E, et al. A phase II randomized study of topical intrarectal administration of amifostine for the prevention of acute radiation-induced rectal toxicity. Strahlenther Onkol. 2004;180:557-62 pubmed
    To investigate the cytoprotective effect of intrarectal amifostine administration on acute radiation-induced rectal toxicity...
  21. Werner Wasik M, Langer C, Movsas B. Amifostine in chemoradiation therapy for non-small cell lung cancer: review of experience and design of a phase II trial assessing subcutaneous and intravenous bolus administration. Semin Oncol. 2005;32:S105-8 pubmed
    ..b>Amifostine at different doses and schedules has been found to reduce frequency or severity of esophagitis in this setting...
  22. Pamujula S, Graves R, Moiseyev R, Bostanian L, Kishore V, Mandal T. Preparation of polylactide-co-glycolide and chitosan hybrid microcapsules of amifostine using coaxial ultrasonic atomizer with solvent evaporation. J Pharm Pharmacol. 2008;60:283-9 pubmed publisher
    ..of this study was to evaluate the effect of various processing and formulation factors on the characteristics of amifostine hybrid microcapsules. Amifostine-loaded hybrid microcapsules were prepared using PLGA and chitosan...
  23. Nieder C, Price R, Rivera B, Andratschke N, Ang K. Effects of insulin-like growth factor-1 (IGF-1) and amifostine in spinal cord reirradiation. Strahlenther Onkol. 2005;181:691-5 pubmed
    To test whether insulin-like growth factor-1 (IGF-1) and amifostine modulate the reirradiation tolerance of rat cervical spinal cord...
  24. Wynn R, Mehta V. Reduction of treatment breaks and radiation-induced esophagitis and pneumonitis using amifostine in unresectable non-small cell lung cancer patients receiving definitive concurrent chemotherapy and radiation therapy: a prospective community-based cli. Semin Oncol. 2005;32:S99-104 pubmed
    ..8 to 2.0 Gy daily; total dose, 60 to 70 Gy) and amifostine 500 mg subcutaneously or intravenous push daily over a 6- to 7-week period...
  25. Zellos L, Richards W, Capalbo L, Jaklitsch M, Chirieac L, Johnson B, et al. A phase I study of extrapleural pneumonectomy and intracavitary intraoperative hyperthermic cisplatin with amifostine cytoprotection for malignant pleural mesothelioma. J Thorac Cardiovasc Surg. 2009;137:453-8 pubmed publisher
    This study was undertaken to determine maximum tolerated dose and toxicity of intraoperative intracavitary hyperthermic cisplatin perfusion with amifostine after extrapleural pneumonectomy for malignant pleural mesothelioma.
  26. Bensadoun R, Schubert M, Lalla R, Keefe D. Amifostine in the management of radiation-induced and chemo-induced mucositis. Support Care Cancer. 2006;14:566-72 pubmed
    ..The goal of this literature review is to update previously published guidelines for the management of mucositis. This article reports the findings of the subgroup charged with reviewing the literature related to amifostine.
  27. Wakelee H, Fisher G. A phase I trial of irinotecan (CPT-11) with amifostine in patients with metastatic colorectal cancer. Invest New Drugs. 2005;23:241-2 pubmed
  28. Chronidou F, Apostolakis E, Papapostolou I, Grintzalis K, Georgiou C, Koletsis E, et al. Beneficial effect of the oxygen free radical scavenger amifostine (WR-2721) on spinal cord ischemia/reperfusion injury in rabbits. J Cardiothorac Surg. 2009;4:50 pubmed publisher
    ..In this study we examined the influence of Amifostine, a triphosphate free oxygen scavenger, on oxidative stress of spinal cord ischemia-reperfusion in rabbits...
  29. Paunesku D, Paunesku T, Wahl A, Kataoka Y, Murley J, Grdina D, et al. Incidence of tissue toxicities in gamma ray and fission neutron-exposed mice treated with Amifostine. Int J Radiat Biol. 2008;84:623-34 pubmed publisher
    To determine the effects of Amifostine or WR-151,327 on the incidence of lethal and non-lethal toxicities in a large cohort of mice exposed to gamma-ray or fission-spectrum neutron radiation...
  30. Majsterek I, Gloc E, Blasiak J, Reiter R. A comparison of the action of amifostine and melatonin on DNA-damaging effects and apoptosis induced by idarubicin in normal and cancer cells. J Pineal Res. 2005;38:254-63 pubmed
    b>Amifostine is a well-known cell protector and its actions involve free radical scavenging, which is also considered as a mechanism underlying the protective actions of melatonin, a secretory product of the pineal gland...
  31. Yurut Caloglu V, Durmus Altun G, Caloglu M, Usta U, Saynak M, Uzal C, et al. Comparison of protective effects of L-carnitine and amifostine on radiation-induced toxicity to growing bone: histopathology and scintigraphy findings. Asian Pac J Cancer Prev. 2010;11:661-7 pubmed
    ..present study was to evaluate the radioprotective efficacy of L-carnitine (LC) in growing bones in comparison to amifostine. Sixty two-week-old Wistar albino rats were randomly assigned to six equal groups: Group 1, control (CONT); ..
  32. Small W, Winter K, Levenback C, Iyer R, Hymes S, Jhingran A, et al. Extended-field irradiation and intracavitary brachytherapy combined with cisplatin and amifostine for cervical cancer with positive para-aortic or high common iliac lymph nodes: results of arm II of Radiation Therapy Oncology Group (RTOG) 0116. Int J Gynecol Cancer. 2011;21:1266-75 pubmed publisher
    Radiation Therapy Oncology Group (RTOG) 0116 was designed to test the ability of amifostine (Ethyol; MedImmune LLC, Gaithersburg, MD), a cytoprotective agent, to reduce the acute toxicity of combined therapy with extended-field ..
  33. Cetingul N, Midyat L, Kantar M, Demirağ B, Aksoylar S, Kansoy S. Cytoprotective effects of amifostine in the treatment of childhood malignancies. Pediatr Blood Cancer. 2009;52:829-33 pubmed publisher
    ..b>Amifostine has rarely been used in the childhood cancers as a multisystemic protective agent for minimizing these side ..
  34. Kanat O, Evrensel T, Baran I, Coskun H, Zarifoglu M, Turan O, et al. Protective effect of amifostine against toxicity of paclitaxel and carboplatin in non-small cell lung cancer: a single center randomized study. Med Oncol. 2003;20:237-45 pubmed
    In this study we determined the protective role of amifostine against the side effects of the combination of paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC). Chemo-naive patients with NSCLC were eligible...
  35. Segreto H, Oshima C, Franco M, Silva M, Egami M, Teixeira V, et al. Phosphorylation and cytoplasmic localization of MAPK p38 during apoptosis signaling in bone marrow granulocytes of mice irradiated in vivo and the role of amifostine in reducing these effects. Acta Histochem. 2011;113:300-7 pubmed publisher
    ..signaling pathway in bone marrow granulocytes in mice irradiated in vivo and the role of the radioprotector amifostine in ameliorating these responses...
  36. Grdina D, Murley J, Kataoka Y, Baker K, Kunnavakkam R, Coleman M, et al. Amifostine induces antioxidant enzymatic activities in normal tissues and a transplantable tumor that can affect radiation response. Int J Radiat Oncol Biol Phys. 2009;73:886-96 pubmed publisher
    To determine whether amifostine can induce elevated manganese superoxide dismutase (SOD2) in murine tissues and a transplantable SA-NH tumor, resulting in a delayed tumor cell radioprotective effect.
  37. Komaki R, Lee J, Milas L, Lee H, Fossella F, Herbst R, et al. Effects of amifostine on acute toxicity from concurrent chemotherapy and radiotherapy for inoperable non-small-cell lung cancer: report of a randomized comparative trial. Int J Radiat Oncol Biol Phys. 2004;58:1369-77 pubmed
    To determine the ability of amifostine to reduce the severity and/or incidence of the acute toxicities of concurrent chemotherapy and radiotherapy (RT) for non-small-cell lung cancer...
  38. Simone N, Menard C, Soule B, Albert P, Guion P, Smith S, et al. Intrarectal amifostine during external beam radiation therapy for prostate cancer produces significant improvements in Quality of Life measured by EPIC score. Int J Radiat Oncol Biol Phys. 2008;70:90-5 pubmed
    To test whether intrarectal amifostine limits symptoms of radiation proctitis, measured by using the Radiation Therapy Oncology Group (RTOG) gastrointestinal (GI) toxicity score and the Expanded Prostate Cancer Index Composite (EPIC) ..
  39. Geiger G, Parker S, Beothy A, Tucker J, Mullins M, Kao G. Zebrafish as a "biosensor"? Effects of ionizing radiation and amifostine on embryonic viability and development. Cancer Res. 2006;66:8172-81 pubmed
    ..were more pronounced earlier in embryogenesis and with higher radiation doses and were partially reversed by amifostine. The effects of radiation and concurrent treatment with amifostine on the developmental organization of the eye ..
  40. Kanat O, Kurt E, Yalcinkaya U, Evrensel T, Manavoglu O. Comparison of uroprotective efficacy of mesna and amifostine in Cyclophosphamide- induced hemorrhagic cystitis in rats. Indian J Cancer. 2006;43:12-5 pubmed
    ..In this study, we aimed to investigate the role of amifostine in the protection of CYP-induced HC and compare its efficacy with mesna...
  41. Stankiewicz A, Skrzydlewska E, Makieła M. Effects of amifostine on liver oxidative stress caused by cyclophosphamide administration to rats. Drug Metabol Drug Interact. 2002;19:67-82 pubmed
    ..b>Amifostine is a drug that can inactivate ROS...
  42. Brizel D, Overgaard J. Does amifostine have a role in chemoradiation treatment?. Lancet Oncol. 2003;4:378-81 pubmed
    ..The most recent chemical radioprotector to become available clinically is amifostine. On the basis of efficacy data from a phase III randomised trial in patients with head and neck cancer, which ..
  43. Rozalski M, Mirowski M, Balcerczak E, Krajewska U, Młynarski W, Wierzbicki R. Induction of caspase 3 activity, bcl-2 bax and p65 gene expression modulation in human acute promyelocytic leukemia HL-60 cells by doxorubicin with amifostine. Pharmacol Rep. 2005;57:360-6 pubmed
    The influence of amifostine alone and in combination with doxorubicin, cytarabine, and etoposide on the cell growth and on bcl-2, bax and p65 gene expression was investigated in human acute promyelocytic leukemia cell line HL-60...
  44. Suntharalingam M, Jaboin J, Taylor R, Wolf J, Banglore M, Van Echo D, et al. The evaluation of amifostine for mucosal protection in patients with advanced loco-regional squamous cell carcinomas of the head and neck (SCCHN) treated with concurrent weekly carboplatin, paclitaxel, and daily radiotherapy (RT). Semin Oncol. 2004;31:2-7 pubmed
    ..In an attempt to decrease these side effects, we conducted a prospective phase II trial evaluating the role of amifostine (Ethyol, MedImmune Oncology, Inc, Gaithersburg, MD) in patients treated with this concurrent chemoRT scheme...
  45. Trajkovic S, Dobric S, Jacevic V, Dragojevic Simic V, Milovanović Z, Dordević A. Tissue-protective effects of fullerenol C60(OH)24 and amifostine in irradiated rats. Colloids Surf B Biointerfaces. 2007;58:39-43 pubmed
    ..Radioprotective effect was comparable to that of the standard radioprotector amifostine. The aim of this study was to compare the efficacy of fullerenol C(60)(OH)(24) (10 and 100mg/kg i.p...
  46. Movsas B, Scott C, Langer C, Werner Wasik M, Nicolaou N, Komaki R, et al. Randomized trial of amifostine in locally advanced non-small-cell lung cancer patients receiving chemotherapy and hyperfractionated radiation: radiation therapy oncology group trial 98-01. J Clin Oncol. 2005;23:2145-54 pubmed
    To test the ability of the cytoprotectant, amifostine, to reduce chemoradiotherapy-induced esophagitis and evaluate its influence on quality of life (QOL) and swallowing symptoms...
  47. Haddad R, Sonis S, Posner M, Wirth L, Costello R, Braschayko P, et al. Randomized phase 2 study of concomitant chemoradiotherapy using weekly carboplatin/paclitaxel with or without daily subcutaneous amifostine in patients with locally advanced head and neck cancer. Cancer. 2009;115:4514-23 pubmed publisher
    ..the efficacy/toxicity of combining concomitant boost radiation and weekly carboplatin/paclitaxel with or without amifostine in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN)...
  48. Asna N, Lewy H, Ashkenazi I, Deutsch V, Peretz H, Inbar M, et al. Time dependent protection of amifostine from renal and hematopoietic cisplatin induced toxicity. Life Sci. 2005;76:1825-34 pubmed
    ..The present study was aimed to examine if the protection of amifostine against cisplatin toxicity is time dependent...
  49. Giannopoulou E, Papadimitriou E. Amifostine has antiangiogenic properties in vitro by changing the redox status of human endothelial cells. Free Radic Res. 2003;37:1191-9 pubmed
    b>Amifostine is a broad-spectrum cytoprotective agent, selective for normal tissues...
  50. Zois C, Giatromanolaki A, Kainulainen H, Botaitis S, Torvinen S, Simopoulos C, et al. Lung autophagic response following exposure of mice to whole body irradiation, with and without amifostine. Biochem Biophys Res Commun. 2011;404:552-8 pubmed publisher
    ..05). Administration of amifostine (200 mg/kg), 30 min before irradiation, reversed all the LC3A and p62 findings on blots, suggesting restoration ..
  51. Mukherjee N, Carroll B, Spees J, Delay E. Pre-treatment with amifostine protects against cyclophosphamide-induced disruption of taste in mice. PLoS ONE. 2013;8:e61607 pubmed publisher
    ..b>Amifostine is a cytoprotective agent that was previously shown to be effective in preventing chemotherapy-induced mucositis ..
  52. Jellema A, Slotman B, Muller M, Leemans C, Smeele L, Hoekman K, et al. Radiotherapy alone, versus radiotherapy with amifostine 3 times weekly, versus radiotherapy with amifostine 5 times weekly: A prospective randomized study in squamous cell head and neck cancer. Cancer. 2006;107:544-53 pubmed
    The main objective of this study was to investigate whether nondaily intravenous administration of amifostine was as effective as daily intravenous administration with regard to the reduction of the incidence of Grade 2 or greater ..
  53. Buentzel J, Micke O, Adamietz I, Monnier A, Glatzel M, de Vries A. Intravenous amifostine during chemoradiotherapy for head-and-neck cancer: a randomized placebo-controlled phase III study. Int J Radiat Oncol Biol Phys. 2006;64:684-91 pubmed
    Clinical trials demonstrated the efficacy and safety of intravenous (i.v.) or subcutaneous (s.c.) amifostine for reducing xerostomia and mucositis after radiotherapy or radiochemotherapy for head-and-neck cancer...