dietary sodium chloride

Summary

Summary: Sodium chloride used in foods.

Top Publications

  1. Henke N, Schmidt Ullrich R, Dechend R, Park J, Qadri F, Wellner M, et al. Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage. Circ Res. 2007;101:268-76 pubmed
    ..We conclude that in vivo NF-kappaB suppression in endothelial cells stops a signaling cascade leading to reduced hypertension-induced renal damage despite high blood pressure...
  2. Nagase M, Matsui H, Shibata S, Gotoda T, Fujita T. Salt-induced nephropathy in obese spontaneously hypertensive rats via paradoxical activation of the mineralocorticoid receptor: role of oxidative stress. Hypertension. 2007;50:877-83 pubmed
    ..Salt reduced circulating aldosterone but caused renal MR activation at least partially via induction of oxidative stress, and eplerenone effectively improved the nephropathy...
  3. de Benoist B, McLean E, Andersson M, Rogers L. Iodine deficiency in 2007: global progress since 2003. Food Nutr Bull. 2008;29:195-202 pubmed
    ..Iodine deficiency is a global public health problem, and estimates of the extent of the problem were last produced in 2003...
  4. Das D, Chakraborty I, Biswas A, Saha I, Mazumder P, Saha S. Goitre prevalence, urinary iodine and salt iodisation level in a district of West Bengal, India. J Am Coll Nutr. 2008;27:401-5 pubmed
    ..We carried out a study to assess the prevalence of goitre, measure urinary iodine excretion (UIE) levels and to estimate salt iodine content at the household level in Howrah district of West Bengal, India...
  5. Shehata M. Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats. Cardiovasc Diabetol. 2008;7:19 pubmed publisher
  6. Aminorroaya A, Momenzadeh M, Hovsepian S, Haghighi S, Amini M. Thyroid autoantibodies in women with and without thyroid disorders in an iodine-replete area. East Mediterr Health J. 2008;14:325-32 pubmed
    ..5% of patients with hypothyroidism, 73.6% of those with hyperthyroidism, 48.9% of those with simple goitre and 35.8% of the control group (P < 0.001). Autoimmunity may have a role in the genesis of common thyroid disorders...
  7. Azizi F, Mehran L, Sheikholeslam R, Ordookhani A, Naghavi M, Hedayati M, et al. Sustainability of a well-monitored salt iodization program in Iran: marked reduction in goiter prevalence and eventual normalization of urinary iodine concentrations without alteration in iodine content of salt. J Endocrinol Invest. 2008;31:422-31 pubmed
    ..Goiter prevalence and UIC were compared 2 and 7 yr after sustained consumption of uniformly iodized salt by Iranian households...
  8. Hirata K, Kume S, Araki S, Sakaguchi M, Chin Kanasaki M, Isshiki K, et al. Exendin-4 has an anti-hypertensive effect in salt-sensitive mice model. Biochem Biophys Res Commun. 2009;380:44-9 pubmed publisher
    ..Considered together, our results indicate that exendin-4 has anti-hypertensive effects through the attenuation of angII-induced high-salt sensitivity...
  9. Xu H, Laflamme D, Long G. Effects of dietary sodium chloride on health parameters in mature cats. J Feline Med Surg. 2009;11:435-41 pubmed publisher
    ..5% of the diet dm is not harmful to healthy cats...

More Information

Publications62

  1. Van Vliet B, Montani J. The time course of salt-induced hypertension, and why it matters. Int J Obes (Lond). 2008;32 Suppl 6:S35-47 pubmed publisher
  2. Abuye C, Berhane Y, Akalu G, Getahun Z, Ersumo T. Prevalence of goiter in children 6 to 12 years of age in Ethiopia. Food Nutr Bull. 2007;28:391-8 pubmed
    ..Iodine-deficiency disorders are a major public health problem in Ethiopia. In conjunction with implementing control programs, baseline information needs to be established...
  3. He F, MacGregor G. Importance of salt in determining blood pressure in children: meta-analysis of controlled trials. Hypertension. 2006;48:861-9 pubmed
    ..This would result in major reductions in cardiovascular disease. These results in conjunction with other evidence provide strong support for a reduction in salt intake in children...
  4. Fujita T. Aldosterone in salt-sensitive hypertension and metabolic syndrome. J Mol Med (Berl). 2008;86:729-34 pubmed publisher
    ..Therefore, aldosterone/MR activation plays a key role not only in the development of salt-sensitive hypertension, but also in cardiovascular injury in metabolic syndrome, possibly through its function as a feed-forward system...
  5. Shehata M. Genetic and dietary salt contributors to insulin resistance in Dahl salt-sensitive (S) rats. Cardiovasc Diabetol. 2008;7:7 pubmed publisher
  6. Frassetto L, Morris R, Sebastian A. Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet. Am J Physiol Renal Physiol. 2007;293:F521-5 pubmed
    ..Assuming a causal relationship, over their respective ranges of variation, NaCl has approximately 50-100% of the acidosis-producing effect of the diet net acid load...
  7. Cook N, Cutler J, Obarzanek E, Buring J, Rexrode K, Kumanyika S, et al. Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP). BMJ. 2007;334:885-8 pubmed
    ..To examine the effects of reduction in dietary sodium intake on cardiovascular events using data from two completed randomised trials, TOHP I and TOHP II...
  8. Melander O, von Wowern F, Frandsen E, Burri P, Willsteen G, Aurell M, et al. Moderate salt restriction effectively lowers blood pressure and degree of salt sensitivity is related to baseline concentration of renin and N-terminal atrial natriuretic peptide in plasma. J Hypertens. 2007;25:619-27 pubmed
    ..Furthermore, we tested whether the basal plasma concentration of renin or N-terminal atrial natriuretic peptide (Nt-proANP) predict the degree of salt sensitivity...
  9. Orlov S, Mongin A. Salt-sensing mechanisms in blood pressure regulation and hypertension. Am J Physiol Heart Circ Physiol. 2007;293:H2039-53 pubmed
  10. He F, Marrero N, MacGregor G. Salt and blood pressure in children and adolescents. J Hum Hypertens. 2008;22:4-11 pubmed
    ..The consistent finding of our present analysis of a random sample of free-living individuals with that from controlled salt reduction trials provides further support for a reduction in salt intake in children and adolescents...
  11. Joshi A, Banjara M, Bhatta L, Rikimaru T, Jimba M. Insufficient level of iodine content in household powder salt in Nepal. Nepal Med Coll J. 2007;9:75-8 pubmed
    ..6 ppm (95.0% CI= 31.7- 33.4) and 30.6 ppm respectively. In the community level, people are still using the non-iodized salt. To eliminate the IDD more efforts are required at program implementation and monitoring level...
  12. de Boer M, Ijzerman R, de Jongh R, Eringa E, Stehouwer C, Smulders Y, et al. Birth weight relates to salt sensitivity of blood pressure in healthy adults. Hypertension. 2008;51:928-32 pubmed publisher
    ..Birth weight is associated with salt sensitivity of blood pressure, and this may play a role in the maintenance of elevated blood pressure in individuals with a low birth weight...
  13. Kotwal A, Priya R, Qadeer I. Goiter and other iodine deficiency disorders: A systematic review of epidemiological studies to deconstruct the complex web. Arch Med Res. 2007;38:1-14 pubmed
    ..This imposes specific problems and necessitates area-specific solutions instead of a universal solution, which apart from being less effective may be harmful in the long run...
  14. Assey V, Peterson S, Greiner T. Sustainable universal salt iodization in low-income countries - time to re-think strategies?. Eur J Clin Nutr. 2008;62:292-4 pubmed
    ..Sustained iodine deficiency control requires sustainable mechanisms for iodine supplementation. We aim to describe the status of salt iodation machines, salt producers' experiences and quality of salt produced in Tanzania...
  15. Sebotsa M, Adjei R. The evaluation of the iodine content of table salt in Lesotho. Afr J Health Sci. 2002;9:139-45 pubmed
    ..81.8% of the households use adequately iodised salt. This however does not meet WHO criteria for elimination of IDD as a public health problem since less than 90% of effectively iodised salt is being used at household level...
  16. Sen T, Biswas A, Chakrabarty I, Das D, Ramakrishnan R, Manickam P, et al. Persistence of iodine deficiency in Gangetic flood-prone area, West Bengal, India. Asia Pac J Clin Nutr. 2006;15:528-32 pubmed
    ..However, the persistence of non-iodised salt consumption indicates that an intensification of universal salt iodisation program is needed...
  17. Heydarian P, Ordookhani A, Azizi F. Goiter rate, serum thyrotropin, thyroid autoantibodies and urinary iodine concentration in Tehranian adults before and after national salt iodization. J Endocrinol Invest. 2007;30:404-10 pubmed
    ..Benefits of iodine supplementation far outweigh its hazards in Tehranian adults...
  18. Leonard A, Chafe L, Montani J, Van Vliet B. Increased salt-sensitivity in endothelial nitric oxide synthase-knockout mice. Am J Hypertens. 2006;19:1264-9 pubmed
    ..In the present study we compared the effects of a high-salt diet on the blood pressure response of eNOS knockout (eNOS-/-) and control (eNOS+/+) mice...
  19. Assey V, Greiner T, Mzee R, Abuu H, Mgoba C, Kimboka S, et al. Iodine deficiency persists in the Zanzibar Islands of Tanzania. Food Nutr Bull. 2006;27:292-9 pubmed
    ..It is estimated that more than 1.6 billion people live in iodine-deficient environments, yet there are still some countries and areas where the prevalence of iodine-deficiency disorders is unknown...
  20. Assey V, Mgoba C, Mlingi N, Sanga A, Ndossi G, Greiner T, et al. Remaining challenges in Tanzania's efforts to eliminate iodine deficiency. Public Health Nutr. 2007;10:1032-8 pubmed
    ..To determine iodine levels in salt and iodine deficiency prevalence in school-aged children in 16 districts in Tanzania with previous severe iodine deficiency...
  21. Aneas I, Rodrigues M, Pauletti B, Silva G, Carmona R, Cardoso L, et al. Congenic strains provide evidence that four mapped loci in chromosomes 2, 4, and 16 influence hypertension in the SHR. Physiol Genomics. 2009;37:52-7 pubmed publisher
    ..Collectively, these data reveal previously unsuspected nuances of the physiological roles of each of the four mapped BP QTLs in the SHR under basal and/or salt loading conditions unforeseen by the analysis of the F2 cross...
  22. Al Dujaili E, Mullins L, Bailey M, Kenyon C. Development of a highly sensitive ELISA for aldosterone in mouse urine: validation in physiological and pathophysiological states of aldosterone excess and depletion. Steroids. 2009;74:456-62 pubmed publisher
    ..A sensitive and specific assay for aldosterone is therefore needed to monitor adrenocortical activity in murine studies of renal function and cardiovascular diseases...
  23. Yadav S, Gupta S, Godbole M, Jain M, Singh U, V Pavithran P, et al. Persistence of severe iodine-deficiency disorders despite universal salt iodization in an iodine-deficient area in northern India. Public Health Nutr. 2010;13:424-9 pubmed publisher
    ..The aim of the present study was to determine the impact of universal salt iodization (USI) on the prevalence of iodine deficiency in the population of an area previously known to have severe iodine deficiency in India...
  24. Rommens C, Shakya R, Heap M, Fessenden K. Tastier and healthier alternatives to French fries. J Food Sci. 2010;75:H109-15 pubmed publisher
    ..Upon processing, they also absorbed 22% less oil, contained 26% less salt, and displayed superior sensory properties. Thus, ring fries may represent an attractive alternative to French fries as processed staple food...
  25. Bernberg E, Andersson I, Tidstrand S, Johansson M, Bergstrom G. Repeated exposure to stressors do not accelerate atherosclerosis in ApoE-/- mice. Atherosclerosis. 2009;204:90-5 pubmed publisher
    ..Furthermore, stress chronically decreased body weight gain and increased urinary corticosterone levels. Notably, despite an apparent stress effect, stress affected neither atherogenesis nor plaque morphology...
  26. de Resende M, Greene A. Effect of ANG II on endothelial cell apoptosis and survival and its impact on skeletal muscle angiogenesis after electrical stimulation. Am J Physiol Heart Circ Physiol. 2008;294:H2814-21 pubmed publisher
    ..Furthermore, under normal conditions, ANG II increases EC viability and protects EC from apoptosis possibly by inactivation of the mitochondrial apoptotic pathway...
  27. Shakir M, Krook L, Schraml F, Hays J, Clyde P. Symptomatic hyponatremia in association with a low-iodine diet and levothyroxine withdrawal prior to I131 in patients with metastatic thyroid carcinoma. Thyroid. 2008;18:787-92 pubmed publisher
    ..We report five patients with papillary or follicular thyroid carcinoma who developed symptomatic hyponatremia during LT4 withdrawal and low-iodine diet...
  28. Dar N, Mir M, Salam I, Malik M, Gulzar G, Yatoo G, et al. Association between copper excess, zinc deficiency, and TP53 mutations in esophageal squamous cell carcinoma from Kashmir Valley, India--a high risk area. Nutr Cancer. 2008;60:585-91 pubmed publisher
    ..Further prospective cohort studies are warranted to determine whether change in the plasma zinc and copper homeostasis may represent an independent risk factor for this malignancy as well as a possible target for preventive intervention...
  29. Fujita T. Mineralocorticoid receptors, salt-sensitive hypertension, and metabolic syndrome. Hypertension. 2010;55:813-8 pubmed publisher
    ..Thus, both salt and obesity activate Rac1 and cause MR activation. Abnormal activation of the aldosterone/MR pathway plays a key role in the development of salt-sensitive hypertension and renal injury in metabolic syndrome...
  30. Zheng L, Sun Z, Zhang X, Xu C, Li J, Hu D, et al. Predictors of progression from prehypertension to hypertension among rural Chinese adults: results from Liaoning Province. Eur J Cardiovasc Prev Rehabil. 2010;17:217-22 pubmed publisher
    ..Individuals with prehypertension are at a high risk of developing hypertension. Little is known about the predictors of progression from prehypertesion to hypertension in rural Chinese adults...
  31. Louhelainen M, Merasto S, Finckenberg P, Vahtola E, Kaheinen P, Leskinen H, et al. Effects of calcium sensitizer OR-1986 on a cardiovascular mortality and myocardial remodelling in hypertensive Dahl/Rapp rats. J Physiol Pharmacol. 2009;60:41-7 pubmed
    ..The present study also underscores the importance of cellular senescence in the pathogenesis of salt-induced hypertensive heart disease...
  32. Kim G, Lee H. Frequent consumption of certain fast foods may be associated with an enhanced preference for salt taste. J Hum Nutr Diet. 2009;22:475-80 pubmed publisher
    ..The present study aimed to investigate the effects of liking or frequent eating of high-salt food on salt taste perception among schoolchildren...
  33. do Carmo J, Tallam L, Roberts J, Brandon E, Biglane J, da Silva A, et al. Impact of obesity on renal structure and function in the presence and absence of hypertension: evidence from melanocortin-4 receptor-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2009;297:R803-12 pubmed publisher
  34. Espelid I. Caries preventive effect of fluoride in milk, salt and tablets: a literature review. Eur Arch Paediatr Dent. 2009;10:149-56 pubmed
    ..This literature has been evaluated in different evidence based reviews...
  35. Cornélio M, Gallani M, Godin G, Rodrigues R, Mendes R, Nadruz Junior W. Development and reliability of an instrument to measure psychosocial determinants of salt consumption among hypertensive patients. Rev Lat Am Enfermagem. 2009;17:701-7 pubmed
    ..70 and significant intra-class correlation coefficients were observed for most variables, indicating the temporal stability of the measured concepts. The developed instrument exhibited evidence of both content validity and reliability...
  36. Li J, Zhang S, Yan L, Ren M, Wang C, Cheng H. [Primary study on the effects of high-salt diet on the myocardium and the related mechanisms]. Zhonghua Yi Xue Za Zhi. 2009;89:1573-6 pubmed
    ..The study was to evaluate the effects of high-salt diet on the blood pressure and myocardium in Sprague-Dawley rats and to investigate the related mechanisms...
  37. Ying W, Aaron K, Wang P, Sanders P. Potassium inhibits dietary salt-induced transforming growth factor-beta production. Hypertension. 2009;54:1159-63 pubmed publisher
  38. Capasso G, Rizzo M, Garavaglia M, Trepiccione F, Zacchia M, Mugione A, et al. Upregulation of apical sodium-chloride cotransporter and basolateral chloride channels is responsible for the maintenance of salt-sensitive hypertension. Am J Physiol Renal Physiol. 2008;295:F556-67 pubmed publisher
    ..17 +/- 0.59 (n = 23) in MHS rats (P < 0.05). The data indicate that, in salt-sensitive hypertension, there is a strong upregulation, both of NCC and ClC-K along the DCT, which explains the persistence of hypertension...
  39. Meyer Lueckel H, Bitter K, Hopfenmuller W, Paris S. Reexamination of caries and fluorosis experience of children in an area of Jamaica with relatively high fluorosis prevalence. Caries Res. 2009;43:250-3 pubmed publisher
    ..Fluorosis prevalence was high particularly in 6-year-olds. Thus, risks and benefits from use of fluorides from multiple sources should be monitored carefully...
  40. Gibson S. Salt intake is related to soft drink consumption in children and adolescents: a link to obesity?. Hypertension. 2008;51:e54; author reply e55 pubmed publisher
  41. Zimmermann M. Research on iodine deficiency and goiter in the 19th and early 20th centuries. J Nutr. 2008;138:2060-3 pubmed
    ..Switzerland's iodized salt program has been operating uninterrupted since 1922. Today, control of the iodine deficiency disorders is an integral part of most national nutrition strategies...
  42. McLoone V, Ringwood J, Van Vliet B. A multi-component model of the dynamics of salt-induced hypertension in Dahl-S rats. BMC Physiol. 2009;9:20 pubmed publisher
    ..To better understand these components, the present study sought to model the dynamics of salt-induced hypertension in the Dahl salt sensitive (Dahl-S) rat using 3 sets of time course data...
  43. Balbi A, Francescato H, Marin E, Costa R, Coimbra T. Roles of mitogen-activated protein kinases and angiotensin II in renal development. Braz J Med Biol Res. 2009;42:38-43 pubmed
    ..Several studies have shown that AII and MAPKs play an important role in renal development. However, the relationship between the effects of AII and MAPK activation on renal development is still unclear...
  44. Wang H, Shimosawa T, Matsui H, Kaneko T, Ogura S, Uetake Y, et al. Paradoxical mineralocorticoid receptor activation and left ventricular diastolic dysfunction under high oxidative stress conditions. J Hypertens. 2008;26:1453-62 pubmed publisher
    ..Salt status plays a pivotal role in angiotensin-II-induced organ damage by regulating reactive oxygen species status, and it is reported that reactive oxygen species activate mineralocorticoid receptors...
  45. Mayer G. An update on the relationship between the kidney, salt and hypertension. Wien Med Wochenschr. 2008;158:365-9 pubmed publisher
    ..As a conclusion, we have to remember that an elevation of arterial pressure can only be maintained if renal function as indicated by pressure natriuresis is impaired...
  46. Kim J, Park S, Nam B. Gastric cancer and salt preference: a population-based cohort study in Korea. Am J Clin Nutr. 2010;91:1289-93 pubmed publisher
    ..Although the incidence of gastric cancer is declining, it remains the most common cancer in Korea. There have been discrepancies in epidemiologic studies regarding a causal relation between highly salted food and the risk of gastric cancer...
  47. Zhao Q, Gu D, Kelly T, Hixson J, Rao D, Jaquish C, et al. Association of genetic variants in the apelin-APJ system and ACE2 with blood pressure responses to potassium supplementation: the GenSalt study. Am J Hypertens. 2010;23:606-13 pubmed publisher
    ..We examined the association of genetic variants in the apelin-APJ system and angiotensin-converting enzyme 2 (ACE2) with BP responses to potassium supplementation...
  48. Elahi S, Rizvi N, Nagra S. Iodine deficiency in pregnant women of Lahore. J Pak Med Assoc. 2009;59:741-3 pubmed
    ..To know extent of iodine deficiency (ID), role of thyroid enlargement (goiter) as marker of ID and current status of iodized salt intake in pregnant women of Lahore...
  49. Brands M, Bell T, RODRIQUEZ N, Polavarapu P, Panteleyev D. Chronic glucose infusion causes sustained increases in tubular sodium reabsorption and renal blood flow in dogs. Am J Physiol Regul Integr Comp Physiol. 2009;296:R265-71 pubmed publisher
    ..However, the volume retention and peripheral edema suggest that systemic vasodilation offsets any potential renal actions to increase MAP in this experimental model in dogs...
  50. Goh S, Leroux B, Groeneschild C, Busch J. On the effect of tastant excluded fillers on sweetness and saltiness of a model food. J Food Sci. 2010;75:S245-9 pubmed publisher
    ..However, the air bubbles were found to change the texture and appearance of the samples. It has been demonstrated that the inclusion of air bubbles offers scope for the reduction of sodium chloride or sucrose in food products...
  51. Kaić Rak A, Pucarin Cvetkovic J, Heim I, Skupnjak B. [Reason for dietary salt reduction and potential effect on population health--WHO recommendation]. Acta Med Croatica. 2010;64:129-32 pubmed
    ..This can be achieved by effective campaigns and social marketing, by ensuring a declaration of salt content on the product, or specially designed signs for food products with low or reduced salt content...
  52. Decano J, Viereck J, McKee A, Hamilton J, Ruiz Opazo N, Herrera V. Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein. Circulation. 2009;119:1501-9 pubmed publisher
    ..Early-life risk factor exposure increases aortic atherosclerosis and blood pressure in humans and animal models; however, limited insight has been gained as to end-organ complications...
  53. Bochud M, Burnier M, Marques Vidal P, Paccaud F. [Reducing dietary salt intake: an important public health strategy in Switzerland]. Rev Med Suisse. 2010;6:494, 496-8 pubmed
    ..The Swiss Federal Office of Public Health is currently running a strategy aiming at reducing dietary salt intake in the Swiss population to less than 5 g per day on the long run (Salz Strategie 2008-2012)...