sodium selenite

Summary

Summary: The disodium salt of selenious acid. It is used therapeutically to supply the trace element selenium and is prepared by the reaction of SELENIUM DIOXIDE with SODIUM HYDROXIDE.

Top Publications

  1. Abedelahi A, Salehnia M, Allameh A, Davoodi D. Sodium selenite improves the in vitro follicular development by reducing the reactive oxygen species level and increasing the total antioxidant capacity and glutathione peroxide activity. Hum Reprod. 2010;25:977-85 pubmed publisher
    The aim of this study was to investigate the effect of sodium selenite (SS) on reactive oxygen species (ROS) production, total antioxidant capacity (TAC) and glutathione peroxide (GPx) activity of cultured pre-antral follicles derived ..
  2. Qin S, Huang K, Gao J, Huang D, Cai T, Pan C. Comparison of glutathione peroxidase 1 and iodothyronine deiodinase 1 mRNA expression in murine liver after feeding selenite or selenized yeast. J Trace Elem Med Biol. 2009;23:29-35 pubmed publisher
    ..1mg/kg selenium as sodium selenite or selenized yeast, respectively. Whole feeding experiment lasted for 30 d...
  3. Muecke R, Schomburg L, Glatzel M, Berndt Skorka R, Baaske D, Reichl B, et al. Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology. Int J Radiat Oncol Biol Phys. 2010;78:828-35 pubmed publisher
    ..We assessed whether adjuvant supplementation with selenium improves the selenium status and reduces side effects of patients treated by radiotherapy (RT) for cervical and uterine cancer...
  4. Zou Y, Niu P, Yang J, Yuan J, Wu T, Chen X. The JNK signaling pathway is involved in sodium-selenite-induced apoptosis mediated by reactive oxygen in HepG2 cells. Cancer Biol Ther. 2008;7:689-96 pubmed
    ..Moreover, NAC effectively blocked apoptosis and decreased the levels of phosphorylated JNK induced by selenite. These results revealed that JNK might be involved in selenite-induced ROS-mediated apoptosis in HepG2 cells...
  5. Weekley C, Aitken J, Vogt S, Finney L, Paterson D, de Jonge M, et al. Metabolism of selenite in human lung cancer cells: X-ray absorption and fluorescence studies. J Am Chem Soc. 2011;133:18272-9 pubmed publisher
    ..Microprobe X-ray absorption near-edge structure spectroscopy (?-XANES) showed that the highly localized Se species was mostly elemental Se...
  6. Zhang J, Wang L, Li G, Anderson L, Xu Y, Witthuhn B, et al. Mouse prostate proteomes are differentially altered by supranutritional intake of four selenium compounds. Nutr Cancer. 2011;63:778-89 pubmed publisher
    ..We propose that the balance of oncogenic vs. suppressor protein patterns in the prostate may impact the direction of PCa risk modification by a given selenium...
  7. Luo H, Yang Y, Huang F, Li F, Jiang Q, Shi K, et al. Selenite induces apoptosis in colorectal cancer cells via AKT-mediated inhibition of ?-catenin survival axis. Cancer Lett. 2012;315:78-85 pubmed publisher
  8. Varma S, Hegde K, Kovtun S. Inhibition of selenite-induced cataract by caffeine. Acta Ophthalmol. 2010;88:e245-9 pubmed publisher
    ..The objective of the investigation was to study possible inhibition of oxidative stress and cataract formation by caffeine in vivo...
  9. Taşkın E, Dursun N. The protection of selenium on adriamycin-induced mitochondrial damage in rat. Biol Trace Elem Res. 2012;147:165-71 pubmed publisher
    ..01). We concluded that selenium is effective in vivo against ADR-induced kidney damage via the restoration of TAS and TOS, which prevented mitochondrial damage...

More Information

Publications62

  1. Kumar B, Tiwari S, Manoj G, Kunwar A, Amrita N, Sivaram G, et al. Anti-unlcer and antimicrobial activities of sodium selenite against Helicobacter pylori: in vitro and in vivo evaluation. Scand J Infect Dis. 2010;42:266-74 pubmed publisher
    Abstract We examined sodium selenite, an inorganic selenium supplement, for its ulcer healing properties and antimicrobial activity against gastric pathogen Helicobacter pylori...
  2. Mániková D, Vlasáková D, Letavayová L, Klobucnikova V, Griac P, Chovanec M. Selenium toxicity toward yeast as assessed by microarray analysis and deletion mutant library screen: a role for DNA repair. Chem Res Toxicol. 2012;25:1598-608 pubmed publisher
    ..Because an inorganic form of Se, sodium selenite (SeL), has often been a part of numerous studies and because this form of Se is used as a dietary supplement ..
  3. Han B, Ren Y, Guan L, Wei W, Hua F, Yang Y, et al. Sodium selenite induces apoptosis in acute promyelocytic leukemia-derived NB4 cells through mitochondria-dependent pathway. Oncol Res. 2009;17:373-81 pubmed
    Our previous study has shown that sodium selenite can cause apoptosis in acute promyelocytic leukemia-derived NB4 cells in a caspase-dependent manner involving Deltapsim disruption and cleavage of Bcl-2, but more detailed mechanism(s) ..
  4. Wang F, Shu G, Peng X, Fang J, Chen K, Cui H, et al. Protective effects of sodium selenite against aflatoxin B1-induced oxidative stress and apoptosis in broiler spleen. Int J Environ Res Public Health. 2013;10:2834-44 pubmed publisher
    The aim of this study was to investigate the possible protective role of sodium selenite on aflatoxin B1-induced oxidative stress and apoptosis in spleen of broilers...
  5. Liao J, Chen C, Maher T, Liu C, Lin M, Wu T, et al. Astaxanthin interacts with selenite and attenuates selenite-induced cataractogenesis. Chem Res Toxicol. 2009;22:518-25 pubmed publisher
    ..This interaction is supported by an in vitro assay and may be partially responsible for the ASTX observed in vivo protection against selenite-induced cataractogenesis...
  6. Sun K, Wu S, Wang Y, Wan X, Thompson H, Zhang J. High-dose sodium selenite toxicity cannot be prevented by the co-administration of pharmacological levels of epigallocatechin-3-gallate which in turn aggravates the toxicity. Food Chem Toxicol. 2013;52:36-41 pubmed publisher
    ..A proof-in-principle experiment was conducted to determine if EGCG would ameliorate sodium selenite-induced growth suppression...
  7. Ahmad H, Tian J, Wang J, Khan M, Wang Y, Zhang L, et al. Effects of dietary sodium selenite and selenium yeast on antioxidant enzyme activities and oxidative stability of chicken breast meat. J Agric Food Chem. 2012;60:7111-20 pubmed publisher
    The effects of sodium selenite (SS) and selenium yeast (SY) alone and in combination (MS) on the selenium (Se) content, antioxidant enzyme activities (AEA), total antioxidant capacity (TAC), and oxidative stability of chicken breast meat ..
  8. Aydin B, Yagci R, Yilmaz F, Erdurmus M, Karadag R, Keskin U, et al. Prevention of selenite-induced cataractogenesis by N-acetylcysteine in rats. Curr Eye Res. 2009;34:196-201 pubmed publisher
    ..To evaluate the effect of N-acetylcysteine on selenite-induced cataract formation in a rat model...
  9. Fang W, Han A, Bi X, Xiong B, Yang W. Tumor inhibition by sodium selenite is associated with activation of c-Jun NH2-terminal kinase 1 and suppression of beta-catenin signaling. Int J Cancer. 2010;127:32-42 pubmed publisher
    ..In this study, we fed intestinal cancer mouse model. Muc2/p21 double mutant mice with a selenium-enriched (sodium selenite) diet for 12 or 24 weeks, and found that sodium selenite significantly inhibited intestinal tumor formation ..
  10. Chen P, Wang L, Li N, Liu Q, Ni J. Comparative proteomics analysis of sodium selenite-induced apoptosis in human prostate cancer cells. Metallomics. 2013;5:541-50 pubmed publisher
    ..However, its mechanism of action remains unclear. This study investigated the mechanism of action of sodium selenite in human prostate cancer PC-3 cells using proteomics...
  11. Králová V, Benešová S, Cervinka M, Rudolf E. Selenite-induced apoptosis and autophagy in colon cancer cells. Toxicol In Vitro. 2012;26:258-68 pubmed publisher
    b>Sodium selenite (Se) is known to induce diverse stress responses in malignant cells which may lead to various types of cell death including apoptosis and/or autophagy...
  12. Guan L, Jiang Q, Li Z, Huang F, Ren Y, Yang Y, et al. The subcellular distribution of MnSOD alters during sodium selenite-induced apoptosis. BMB Rep. 2009;42:361-6 pubmed
    It was reported that high doses of sodium selenite can induce apoptosis of cancer cells, but the molecular mechanisms are poorly understood...
  13. Wojewoda M, Duszynski J, Szczepanowska J. NARP mutation and mtDNA depletion trigger mitochondrial biogenesis which can be modulated by selenite supplementation. Int J Biochem Cell Biol. 2011;43:1178-86 pubmed publisher
    ..Moreover, it could also be tested with regard to other mitochondrial disorders associated with ROS overproduction...
  14. Morgan K, Estevez A, Mueller C, Cacho Valadez B, Miranda Vizuete A, Szewczyk N, et al. The glutaredoxin GLRX-21 functions to prevent selenium-induced oxidative stress in Caenorhabditis elegans. Toxicol Sci. 2010;118:530-43 pubmed publisher
    ..of reactive oxygen species formation was significantly higher in animals after a brief exposure to 5mM sodium selenite. Longer-term exposures lead to a progressive selenium-induced motility impairment that could be partially ..
  15. Todd S, Thomas D, Hendriks W. Selenium balance in the adult cat in relation to intake of dietary sodium selenite and organically bound selenium. J Anim Physiol Anim Nutr (Berl). 2012;96:148-58 pubmed publisher
    The response of cats to dietary sodium selenite (Na(2) SeO(3)) and organically bound selenium was studied in two separate studies with four cats per treatment and three levels of selenium supplementation (targets 1.0, 1.5 and 2...
  16. Wang Y, Ji H, Zheng J, Pei D, Hu S, Qiu S. Protective effect of selenite on renal ischemia/reperfusion injury through inhibiting ASK1-MKK3-p38 signal pathway. Redox Rep. 2009;14:243-50 pubmed publisher
    ..In addition, selenite reduced the MDA level. These findings suggest that the protective action of selenite on ischemia renal injury is associated closely with reducing activation of the ASK1-MKK3-p38 signal pathway...
  17. Romero Pérez A, García García E, Zavaleta Mancera A, Ramirez Bribiesca J, Revilla Vazquez A, Hernández Calva L, et al. Designing and evaluation of sodium selenite nanoparticles in vitro to improve selenium absorption in ruminants. Vet Res Commun. 2010;34:71-9 pubmed publisher
    b>Sodium selenite is used to prevent selenium deficiency known as nutritional muscular dystrophy or white muscle disease...
  18. Qi H, Wei S, Gao X, Yu N, Hu W, Bi S, et al. Ursodeoxycholic acid prevents selenite-induced oxidative stress and alleviates cataract formation: In vitro and in vivo studies. Mol Vis. 2012;18:151-60 pubmed
    ..To evaluate the antioxidative and anticataractogenic potential effect of ursodeoxycholic acid (UDCA) on selenite-induced cataract in vitro and in vivo...
  19. Olm E, Jönsson Videsäter K, Ribera Cortada I, Fernandes A, Eriksson L, Lehmann S, et al. Selenite is a potent cytotoxic agent for human primary AML cells. Cancer Lett. 2009;282:116-23 pubmed publisher
    ..The results strongly suggest a great potential for selenite in the treatment of multi drug resistant AML...
  20. Hoefig C, Renko K, Köhrle J, Birringer M, Schomburg L. Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture. J Nutr Biochem. 2011;22:945-55 pubmed publisher
    ..Incubations with 100 nM sodium selenite, l- or dl-selenocystine, selenodiglutathione or selenomethyl-selenocysteine increased SEPP concentrations in ..
  21. Zhou Y, Zhang S, Liu C, Cai Y. The protection of selenium on ROS mediated-apoptosis by mitochondria dysfunction in cadmium-induced LLC-PK(1) cells. Toxicol In Vitro. 2009;23:288-94 pubmed publisher
    ..Taken together, we concluded that Cd-induced apoptosis was mediated by oxidative stress and selenium produced a significant protection against Cd-induced apoptosis in LLC-PK(1) via ameliorating the mitochondrial dysfunction...
  22. Sakthivel M, Elanchezhian R, Thomas P, Geraldine P. Alterations in lenticular proteins during ageing and selenite-induced cataractogenesis in Wistar rats. Mol Vis. 2010;16:445-53 pubmed
    ..To determine putative alterations in the major lenticular proteins in Wistar rats of different ages and to compare these alterations with those occurring in rats with selenite-induced cataract...
  23. Rooban B, Sasikala V, Sahasranamam V, Abraham A. Vitex negundo modulates selenite-induced opacification and cataractogensis in rat pups. Biol Trace Elem Res. 2010;138:282-92 pubmed publisher
    ..negundo treated (G III). Cataract was induced by the single subcutaneous injection of sodium selenite (4 mg/kg body weight) on the tenth day and V. negundo (2...
  24. Wu X, Huang K, Wei C, Chen F, Pan C. Regulation of cellular glutathione peroxidase by different forms and concentrations of selenium in primary cultured bovine hepatocytes. J Nutr Biochem. 2010;21:153-61 pubmed publisher
    ..5, 1, 1.5, 2, 3, 4 or 5 micromol/L of Se from dl-selenomethionine (Se-Met), sodium selenite (Na(2)SeO(3)) or Kappa-selenocarrageenan (Se-Car)...
  25. Chen X, Duan F, Zhang H, Xiong Y, Wang J. Sodium selenite-induced apoptosis mediated by ROS attack in human osteosarcoma U2OS cells. Biol Trace Elem Res. 2012;145:1-9 pubmed publisher
    b>Sodium selenite (Na(2)SeO(3), SSE) is an inorganic Se compound that is widely used in cancer chemoprevention studies...
  26. Peng X, Cui Y, Cui W, Deng J, Cui H. The decrease of relative weight, lesions, and apoptosis of bursa of fabricius induced by excess dietary selenium in chickens. Biol Trace Elem Res. 2009;131:33-42 pubmed publisher
    ..The purpose of this 42-day study was to investigate the effects of excess dietary sodium selenite on immune function by determining morphological changes and apoptosis of bursa of Fabricius...
  27. Asfour I, El Tehewi M, Ahmed M, Abdel Sattar M, Moustafa N, Hegab H, et al. High-dose sodium selenite can induce apoptosis of lymphoma cells in adult patients with non-Hodgkin's lymphoma. Biol Trace Elem Res. 2009;127:200-10 pubmed publisher
    The present study was undertaken to explore the effect of administration of high doses of sodium selenite on the apoptosis of lymphoma cells in patients with non-Hodgkin's lymphoma (NHL)...
  28. Chen J, Boylan L, Wu C, Spallholz J. Oxidation of glutathione and superoxide generation by inorganic and organic selenium compounds. Biofactors. 2007;31:55-66 pubmed
    ..This redox chemistry may be responsible for selenite and organoselenium toxicity and apoptosis, making possible the design and synthesis of organoselenium-containing pharmaceuticals...
  29. Kabiri M, Amoozegar M, Tabebordbar M, Gilany K, Salekdeh G. Effects of selenite and tellurite on growth, physiology, and proteome of a moderately halophilic bacterium. J Proteome Res. 2009;8:3098-108 pubmed publisher
    ..These results provided new insights into the general mechanisms on the tolerance of halophilic bacteria to these two toxic oxyanions and the use of them for bioremediation of contaminated saline soils and wastes discharge sites...
  30. Jiang Q, Wang Y, Li T, Shi K, Li Z, Ma Y, et al. Heat shock protein 90-mediated inactivation of nuclear factor-?B switches autophagy to apoptosis through becn1 transcriptional inhibition in selenite-induced NB4 cells. Mol Biol Cell. 2011;22:1167-80 pubmed publisher
    ..Previous studies have shown that supranutritional doses of sodium selenite promote apoptosis in human leukemia NB4 cells...
  31. Li W, Hsu F, Liu J, Liao V. The ameliorative and toxic effects of selenite on Caenorhabditis elegans. Food Chem Toxicol. 2011;49:812-9 pubmed publisher
    ..elegans, depending on the amount. Our investigations here thus reinforce our understanding of the ameliorative and toxic effects of selenium on development, reproduction, and cholinergic signaling...
  32. Chen K, Shu G, Peng X, Fang J, Cui H, Chen J, et al. Protective role of sodium selenite on histopathological lesions, decreased T-cell subsets and increased apoptosis of thymus in broilers intoxicated with aflatoxin B?. Food Chem Toxicol. 2013;59:446-54 pubmed publisher
    ..However, supplied dietary sodium selenite could increase the relative weight of thymus and percentages of mature thymocytes, and alleviate ..
  33. Liao J, Chen C, Hu C, Chen W, Wang S, Lin I, et al. Ditopic complexation of selenite anions or calcium cations by pirenoxine: an implication for anti-cataractogenesis. Inorg Chem. 2011;50:365-77 pubmed publisher
    ..These results may provide a rationale for using PRX as an anti-cataract agent and warrant further biological studies...
  34. Sopjani M, Foller M, Gulbins E, Lang F. Suicidal death of erythrocytes due to selenium-compounds. Cell Physiol Biochem. 2008;22:387-94 pubmed publisher
    ..According to Fluo3 fluorescence, selenite (>or=200 microg/l sodium selenite) within 48 hours significantly increased the cytosolic Ca(2+) concentration in human erythrocytes...
  35. Velpandian T, Nirmal J, Gupta P, Vijayakumar A, Ghose S. Evaluation of calcium dobesilate for its anti-cataract potential in experimental animal models. Methods Find Exp Clin Pharmacol. 2010;32:171-9 pubmed publisher
    ..Anti-cataract activity may be due to its antioxidant as well as aldose reductase inhibitor properties. Further studies are in progress to evaluate its clinical efficacy in diabetic cataract. ..
  36. Wang Z, Forceville X, Van Antwerpen P, Piagnerelli M, Ahishakiye D, Macours P, et al. A large-bolus injection, but not continuous infusion of sodium selenite improves outcome in peritonitis. Shock. 2009;32:140-6 pubmed publisher
    Administration of sodium selenite in septic shock has been associated with apparently conflicting results that may be related to different dosing schedules...
  37. Králová V, Brigulová K, Cervinka M, Rudolf E. Antiproliferative and cytotoxic effects of sodium selenite in human colon cancer cells. Toxicol In Vitro. 2009;23:1497-503 pubmed publisher
    b>Sodium selenite has been reported to interfere with cell growth and proliferation and to induce cell death...
  38. Huang F, Nie C, Yang Y, Yue W, Ren Y, Shang Y, et al. Selenite induces redox-dependent Bax activation and apoptosis in colorectal cancer cells. Free Radic Biol Med. 2009;46:1186-96 pubmed publisher
    ..Our results show for the first time that selenite can activate the apoptotic machinery through redox-dependent activation of Bax and further suggest that selenite could be useful in cancer therapy...
  39. Guo S, Shi D, Liao S, Su R, Lin Y, Pan J, et al. Influence of selenium on body weights and immune organ indexes in ducklings intoxicated with aflatoxin B?. Biol Trace Elem Res. 2012;146:167-70 pubmed publisher
    ..1 mg/kg body weight). Group III was administered with AFB(1) (0.1 mg/kg body weight) plus sodium selenite (1 mg/kg body weight). All treatments were given once daily for 21 days...
  40. Li Z, Meng J, Xu T, Qin X, Zhou X. Sodium selenite induces apoptosis in colon cancer cells via Bax-dependent mitochondrial pathway. Eur Rev Med Pharmacol Sci. 2013;17:2166-71 pubmed
    ..We aimed to elucidate a possible mechanism of action by investigating the effects of selenium (Se) on cell cycle arrest and apoptosis in colorectal cancer cells (HCT116 cells and SW620 cells)...
  41. Sakthivel M, Geraldine P, Thomas P. Alterations in the lenticular protein profile in experimental selenite-induced cataractogenesis and prevention by ellagic acid. Graefes Arch Clin Exp Ophthalmol. 2011;249:1201-10 pubmed publisher
    ..This study aimed to evaluate whether ellagic acid, a natural polyphenol with antioxidant properties, prevents alterations in the lenticular protein profile in an experimental model of selenite cataract...
  42. Vibin M, Siva Priya S, N Rooban B, Sasikala V, Sahasranamam V, Abraham A. Broccoli regulates protein alterations and cataractogenesis in selenite models. Curr Eye Res. 2010;35:99-107 pubmed publisher
    ..To study the efficacy of Brassica oleracea var. italica (Broccoli) in the prevention of selenite induced biochemical changes and the incidence of cataractogenesis in vivo...
  43. Mániková D, Vlasáková D, Loduhová J, Letavayová L, Vigasová D, Krascsenitsová E, et al. Investigations on the role of base excision repair and non-homologous end-joining pathways in sodium selenite-induced toxicity and mutagenicity in Saccharomyces cerevisiae. Mutagenesis. 2010;25:155-62 pubmed publisher
    ..Using Saccharomyces cerevisiae we showed that sodium selenite (SeL), an inorganic form of Se, can be toxic and mutagenic in this organism due to its ability to induce DNA ..
  44. Berggren M, Sittadjody S, Song Z, Samira J, Burd R, Meuillet E. Sodium selenite increases the activity of the tumor suppressor protein, PTEN, in DU-145 prostate cancer cells. Nutr Cancer. 2009;61:322-31 pubmed publisher
    ..Trx reductase (TR) is increased by sevenfold in the human prostate cancer cell line, DU-145, after 5 days of sodium selenite (Se) treatment...
  45. Bhattacharyya R, Husbeck B, Feldman D, Knox S. Selenite treatment inhibits LAPC-4 tumor growth and prostate-specific antigen secretion in a xenograft model of human prostate cancer. Int J Radiat Oncol Biol Phys. 2008;72:935-40 pubmed publisher
    ..In this study, we investigated the in vivo effects of selenite as a therapy to treat mice with established LAPC-4 tumors...
  46. Freitas M, Alves V, Sarmento Ribeiro A, Mota Pinto A. Combined effect of sodium selenite and docetaxel on PC3 metastatic prostate cancer cell line. Biochem Biophys Res Commun. 2011;408:713-9 pubmed publisher
    Docetaxel and sodium selenite are well known for their anticancer properties. While resistance to docetaxel remains an obstacle in prostate cancer chemotherapy, sodium selenite, has been exploited as a new therapeutic approach...
  47. Li Z, Shi K, Guan L, Cao T, Jiang Q, Yang Y, et al. ROS leads to MnSOD upregulation through ERK2 translocation and p53 activation in selenite-induced apoptosis of NB4 cells. FEBS Lett. 2010;584:2291-7 pubmed publisher
    Following our previous finding that sodium selenite induces apoptosis in human leukemia NB4 cells, we now show that the expression of the critical antioxidant enzyme manganese superoxide dismutase (MnSOD) is remarkably elevated during ..
  48. Stoppe C, Spillner J, Rossaint R, Coburn M, Schälte G, Wildenhues A, et al. Selenium blood concentrations in patients undergoing elective cardiac surgery and receiving perioperative sodium selenite. Nutrition. 2013;29:158-65 pubmed publisher
    ..The aim of this study was to assess the effects of perioperative high-dose sodium-selenite administration on selenium blood concentrations in cardiac surgical patients...
  49. Yang Y, Huang F, Ren Y, Xing L, Wu Y, Li Z, et al. The anticancer effects of sodium selenite and selenomethionine on human colorectal carcinoma cell lines in nude mice. Oncol Res. 2009;18:1-8 pubmed
    ..cell line xenografts to evaluate the chemotherapeutic potential of selenium containing compounds such as sodium selenite (SSe) and selenomethionine (SeMet). Three doses of anticancer drugs were used, including 0...
  50. Misra S, Niyogi S. Selenite causes cytotoxicity in rainbow trout (Oncorhynchus mykiss) hepatocytes by inducing oxidative stress. Toxicol In Vitro. 2009;23:1249-58 pubmed publisher
    ..Overall, the present study suggests that selenite exposure at high level causes oxidative damage to trout hepatocytes, probably by inducing the imbalance of intracellular glutathione (GSH) redox...
  51. Zhao R, Xiang N, Domann F, Zhong W. Effects of selenite and genistein on G2/M cell cycle arrest and apoptosis in human prostate cancer cells. Nutr Cancer. 2009;61:397-407 pubmed publisher
  52. Tian J, Ning S, Knox S. Sodium selenite radiosensitizes hormone-refractory prostate cancer xenograft tumors but not intestinal crypt cells in vivo. Int J Radiat Oncol Biol Phys. 2010;78:230-6 pubmed publisher
    We have previously shown that sodium selenite (SSE) increases radiation-induced cell killing of human prostate carcinoma cells in vitro...
  53. Suzuki M, Endo M, Shinohara F, Echigo S, Rikiishi H. Differential apoptotic response of human cancer cells to organoselenium compounds. Cancer Chemother Pharmacol. 2010;66:475-84 pubmed publisher