sodium cyanide


Summary: A highly poisonous compound that is an inhibitor of many metabolic processes and is used as a test reagent for the function of chemoreceptors. It is also used in many industrial processes.

Top Publications

  1. Murahashi S, Komiya N, Terai H, Nakae T. Aerobic ruthenium-catalyzed oxidative cyanation of tertiary amines with sodium cyanide. J Am Chem Soc. 2003;125:15312-3 pubmed
    RuCl3-catalyzed oxidative cyanation of tertiary amines with sodium cyanide under molecular oxygen (1 atm) at 60 degrees C gives the corresponding alpha-aminonitriles, which are versatile synthetic intermediates of various compounds such ..
  2. Murahashi S, Nakae T, Terai H, Komiya N. Ruthenium-catalyzed oxidative cyanation of tertiary amines with molecular oxygen or hydrogen peroxide and sodium cyanide: sp3 C-H bond activation and carbon-carbon bond formation. J Am Chem Soc. 2008;130:11005-12 pubmed publisher
    Ruthenium-catalyzed oxidative cyanation of tertiary amines with molecular oxygen in the presence of sodium cyanide and acetic acid gives the corresponding alpha-aminonitriles, which are highly useful intermediates for organic synthesis...
  3. Saha S, Ghosh A, Mahato P, Mishra S, Mishra S, Suresh E, et al. Specific recognition and sensing of CN- in sodium cyanide solution. Org Lett. 2010;12:3406-9 pubmed publisher
    Specific recognition of CN(-) in sodium cyanide solution was achieved using two imidazole-based receptors (A and B). Visually detectable color changes were associated with the formation of hydrogen bonded adducts, A.CN(-) and B.CN(-)...
  4. Sugishita K, Su Z, Li F, Philipson K, Barry W. Gender influences [Ca(2+)](i) during metabolic inhibition in myocytes overexpressing the Na(+)-Ca(2+) exchanger. Circulation. 2001;104:2101-6 pubmed
    ..This gender difference appears to be mediated in part by an inhibitory effect of estrogen on the rise in [Na(+)](i), an NCX modifier, during MI. ..
  5. Tekkök S, Brown A, Ransom B. Axon function persists during anoxia in mammalian white matter. J Cereb Blood Flow Metab. 2003;23:1340-7 pubmed
    ..These observations have implications for white matter energy metabolism and susceptibility to injury during focal ischemia. ..
  6. Galicia P, Batina N, Gonzalez I. The relationship between the surface composition and electrical properties of corrosion films formed on carbon steel in alkaline sour medium: an XPS and EIS study. J Phys Chem B. 2006;110:14398-405 pubmed
    ..These phenomena jointly control the passivity of the interface attacked by the corrosive medium. ..
  7. Ford J, Gugger P, Wild S, Mendz G. Phenylphosphonate transport by Helicobacter pylori. Helicobacter. 2007;12:609-15 pubmed
    ..amiloride, valinomycin, and nigericin reduced the rate of phenylphosphonate transport; sodium azide and sodium cyanide increased the transport rate; and monensin had no effect. The kinetics and properties of H...
  8. Kitagawa H, Yamazaki T, Akiyama T, Nosaka S, Mori H. Isoflurane attenuates myoglobin release during ischemic and/or reperfusion periods. Acta Anaesthesiol Scand. 2008;52:650-7 pubmed publisher
    ..To determine whether the isoflurane induced myocardial protection against chemical hypoxia, sodium cyanide (30 mM) was administered and dialysate myoglobin levels were measured with (n=6) and without pre-exposure to ..
  9. Wick A, Marincas O, Moldovan Z, Ternes T. Sorption of biocides, triazine and phenylurea herbicides, and UV-filters onto secondary sludge. Water Res. 2011;45:3638-52 pubmed publisher

More Information

Publications106 found, 100 shown here

  1. Jones S, Dutschmann M. Testing the hypothesis of neurodegeneracy in respiratory network function with a priori transected arterially perfused brain stem preparation of rat. J Neurophysiol. 2016;115:2593-607 pubmed publisher
    ..not produce stable rhythmic respiratory bursting, even when the arterial chemoreceptors were stimulated with sodium cyanide (NaCN)...
  2. Tiffert T, Daw N, Perdomo D, Lew V. A fast and simple screening test to search for specific inhibitors of the plasma membrane calcium pump. J Lab Clin Med. 2001;137:199-207 pubmed
    ..Vanadate was used as a test substance to assess the effect of putative pump inhibitors. This method offers a cost-efficient and easily automated alternative for testing large numbers of natural or synthetic agents. ..
  3. Sasaki T, Unno K, Tahara S, Shimada A, Chiba Y, Hoshino M, et al. Age-related increase of superoxide generation in the brains of mammals and birds. Aging Cell. 2008;7:459-69 pubmed publisher
    ..This suggested that superoxide production itself may increase with age. We speculated that reactive oxygen may be a signal to determine the aging process. ..
  4. Rajashree R, Koster J, Markova K, Nichols C, Hofmann P. Contractility and ischemic response of hearts from transgenic mice with altered sarcolemmal K(ATP) channels. Am J Physiol Heart Circ Physiol. 2002;283:H584-90 pubmed
  5. Huang W, Yang Q, Ward R, Priestley J. Hypoxia-induced apoptosis in adult rat dorsal root ganglion neurons in vitro. Neuroreport. 2005;16:89-93 pubmed
    ..Cyanide response provides a simple assay for testing neuroprotective agents and examining underlying mechanisms. ..
  6. Niquet J, Seo D, Allen S, Wasterlain C. Hypoxia in presence of blockers of excitotoxicity induces a caspase-dependent neuronal necrosis. Neuroscience. 2006;141:77-86 pubmed
    ..Caspase inhibitors were neuroprotective. These results suggest that "non-excitotoxic hypoxic neuronal death" requires the activation in many neurons of a cell death program originating in mitochondria and leading to necrosis. ..
  7. Lu Z, Gao J, Zuckerman J, Mathias R, Gaudette G, Krukenkamp I, et al. Two-pore K+ channels, NO and metabolic inhibition. Biochem Biophys Res Commun. 2007;363:194-6 pubmed
    ..Ischemic preconditioning is known to be induced by metabolic inhibition using sodium cyanide (NaCN) in single cardiomyocytes...
  8. Gruenwedel D. Hg(II)-induced changes in DNA-circular dichroism: reversible transitions between right-handed and left-handed screwness. Z Naturforsch C. 1989;44:1015-9 pubmed
    ..The CD changes are totally reversible upon the removal of Hg(II), at least up to r = 1.0, demonstrating that Hg(II) keeps all base pairs in register. ..
  9. Alvarez Buylla R, Huberman A, Montero S, Lemus M, Valles V, de Alvarez Buylla E. Induction of brain glucose uptake by a factor secreted into cerebrospinal fluid. Brain Res. 2003;994:124-33 pubmed
    ..Here we show that 2-8 min after local injection of sodium cyanide (NaCN) into the CBR or after electrical stimulation of the carotid sinus nerve in dogs and rats, brain glucose ..
  10. Prashanth M, Neelagund S. Free cyanide-induced biochemical changes in nitrogen metabolism of the Indian major carp Cirrhinus mrigala. J Basic Clin Physiol Pharmacol. 2007;18:277-87 pubmed
    ..At the lethal concentration, significant changes were noticed on day 4 for both parameters. The normal condition was restored only at the sublethal concentration. ..
  11. Nicholas H, Taylor J. Central nervous system demyelinating diseases and increased release of cholesterol into the urinary system of rats. Lipids. 1994;29:611-7 pubmed
    ..When labeled rats were given demyelinating agents (triethyl tin chloride, hexachlorophene, sodium cyanide) and when experimental allergic encephalomyelitis was induced, a measurable increase in urinary 14C label ..
  12. Peasley M, Shi R. Resistance of isolated mammalian spinal cord white matter to oxygen-glucose deprivation. Am J Physiol Cell Physiol. 2002;283:C980-9 pubmed
    ..To further deprive the axons of metabolic substrate, we added 2 mM sodium cyanide or 2 mM sodium azide, both mitochondrial suppressors, to the ischemic medium, which completely abolished CAP ..
  13. Chen X, Chon K, Solomon I. Chemical activation of pre-Bötzinger complex in vivo reduces respiratory network complexity. Am J Physiol Regul Integr Comp Physiol. 2005;288:R1237-47 pubmed
    ..014+/-0.067; a slightly enhanced magnitude reduction in MSEn was observed. Focal pre-BötC hypoxia (induced by sodium cyanide; NaCN; 1 mM; 20 nl; n=2) also elicited a reduction in both ApEn and MSEn, similar to those observed for the ..
  14. Mutlu G, Leikin J, Oh K, Factor P. An unresponsive biochemistry professor in the bathtub. Chest. 2002;122:1073-6 pubmed
  15. Wang T, Taylor E, Reid S, Milsom W. Interactive effects of mechano- and chemo-receptor inputs on cardiorespiratory outputs in the toad. Respir Physiol Neurobiol. 2004;140:63-76 pubmed
  16. Rose K, Ouellette Y, Bolon M, Tyml K. Hypoxia/reoxygenation reduces microvascular endothelial cell coupling by a tyrosine and MAP kinase dependent pathway. J Cell Physiol. 2005;204:131-8 pubmed
    ..We predict that a short-term H/R can rapidly compromise microvascular function in terms of reduced cellular communication along the vascular wall. ..
  17. Jones J, de Burgh Daly M. Reflex cardiac dromotropic responses to stimulation of the carotid and aortic chemoreceptors in the anaesthetized cat. J Physiol. 1997;502 ( Pt 2):461-7 pubmed
    ..or atrioventricular conduction time) in response to selective stimulation of the carotid and aortic bodies by sodium cyanide were studied in the anaesthetized cat...
  18. Skinner M, Ramage A, Jordan D. Modulation of reflexly evoked vagal bradycardias by central 5-HT1A receptors in anaesthetized rabbits. Br J Pharmacol. 2002;137:861-73 pubmed
    ..baroreceptors by electrical stimulation of the aortic nerve and chemoreceptors by injections of sodium cyanide (NaCN) in atenolol-pretreated anaesthetized rabbits were studied. 2. Buspirone (100 micro g kg(-1); i.c...
  19. McDonald M, Gilmour K, Barimo J, Frezza P, Walsh P, Perry S. Is urea pulsing in toadfish related to environmental O2 or CO2 levels?. Comp Biochem Physiol A Mol Integr Physiol. 2007;146:366-74 pubmed
    ..Our findings suggest that neither the environmental conditions of hypoxia, hyperoxia or hypercapnia, nor direct branchial chemoreceptor activation by NaCN play a major role in the regulation of pulsatile urea excretion in toadfish. ..
  20. Nakos M, Pepelanova I, Beutel S, Krings U, Berger R, Scheper T. Isolation and analysis of vitamin B12 from plant samples. Food Chem. 2017;216:301-8 pubmed publisher
    ..Vitamin B12 was extracted in the presence of sodium cyanide, to transform all forms of cobalamin into cyanocobalamin...
  21. Ma J, Tamai K, Ichii M, Wu G. A rice mutant defective in Si uptake. Plant Physiol. 2002;130:2111-7 pubmed
    ..Analysis of F(2) populations between GR1 and WT showed that roots with high Si uptake and roots with low Si uptake segregated at a 3:1 ratio, suggesting that GR1 is a recessive mutant of Si uptake. ..
  22. Kiang J, Warke V, Tsokos G. NaCN-induced chemical hypoxia is associated with altered gene expression. Mol Cell Biochem. 2003;254:211-6 pubmed
    b>Sodium cyanide (NaCN)-induced chemical hypoxia is known to increase intracellular free calcium concentration and reduce cell survival, but its effect on gene expression has not been studied...
  23. Rheault M, Debicki D, O Donnell M. Characterization of tetraethylammonium uptake across the basolateral membrane of the Drosophila Malpighian (renal) tubule. Am J Physiol Regul Integr Comp Physiol. 2005;289:R495-R504 pubmed
    ..Our results also suggest that the mechanism of basolateral TEA uptake by Malpighian tubules is distinct from that found in vertebrate renal tubules. ..
  24. Copp S, Stone A, Yamauchi K, Kaufman M. Effects of peripheral and spinal κ-opioid receptor stimulation on the exercise pressor reflex in decerebrate rats. Am J Physiol Regul Integr Comp Physiol. 2014;307:R281-9 pubmed publisher
    ..In rats with ligated femoral arteries, the pressor response to stimulation of peripheral chemoreceptors by sodium cyanide was not changed by intrathecal U62066 injections, indicating that these injections had no direct effect on the ..
  25. Borisov V, Forte E, Davletshin A, Mastronicola D, Sarti P, Giuffrè A. Cytochrome bd oxidase from Escherichia coli displays high catalase activity: an additional defense against oxidative stress. FEBS Lett. 2013;587:2214-8 pubmed publisher
    ..5?M) and azide. The activity, possibly associated with heme-b595, was also observed in catalase-deficient E. coli cells following cytochrome bd over-expression suggesting a protective role against oxidative stress in vivo...
  26. Iwig M, Glasser D, Struck H. [Human cultured lens cells. II. Characterization of established lens cell lines and test of their suitability for cytotoxicity tests]. Klin Monbl Augenheilkd. 2001;218:251-61 pubmed
    ..The established cell lines proved to be highly sensitive to ethanol and mitomycin C. The established human lens cell lines are well suited to screen for cytotoxic substances in vitro which might be cataractogenic risk factors in vivo. ..
  27. Rybak I, Shevtsova N, ST JOHN W, Paton J, Pierrefiche O. Endogenous rhythm generation in the pre-Bötzinger complex and ionic currents: modelling and in vitro studies. Eur J Neurosci. 2003;18:239-57 pubmed
    ..These findings are discussed in the context of the role of endogenous bursting activity in the respiratory rhythm generation in vivo vs. in vitro and during normal breathing in vivo vs. gasping. ..
  28. Micheli Campbell M, Campbell H, Kalinin A, Rantin F. The relationship between O2 chemoreceptors, cardio-respiratory reflex and hypoxia tolerance in the neotropical fish Hoplias lacerdae. Comp Biochem Physiol A Mol Integr Physiol. 2009;154:224-32 pubmed publisher
    ..lacerdae with hypoxia-tolerant species revealed a relationship existent between general oxygenation of the individual species environment, its cardio-respiratory response to hypoxia and the characterization of O(2) chemoreceptors. ..
  29. Hand W, Hand D. [Mechanisms of azithromycin accumulation and efflux in human polymorphonuclear leukocytes]. Antibiot Khimioter. 2002;47:6-12 pubmed
    ..Active concentration and prolonged retention of azithromycin by phagocytic cells should allow delivery and subsequent release of accumulated drug at sites of infection. ..
  30. Mathangi D, Namasivayam A. Protective effect of diltiazem on cyanide-induced neurotoxicity in Wistar strain rats. Food Chem Toxicol. 2004;42:605-8 pubmed
    ..These results suggest that diltiazem may mitigate the harmful effects of cyanide by interfering with influx of calcium ions and release of the biogenic amines. ..
  31. Kiritsis C, Manta S, Parmenopoulou V, Dimopoulou A, Kollatos N, Papasotiriou I, et al. Stereocontrolled synthesis of 4'-C-cyano and 4'-C-cyano-4'-deoxy pyrimidine pyranonucleosides as potential chemotherapeutic agents. Carbohydr Res. 2012;364:8-14 pubmed publisher
    ..Reaction of compounds 6a,b, and 7c with sodium cyanide and subsequent deprotection gave the target 1-(4'-C-cyano-?-D-mannopyranosyl)nucleosides 12a-c...
  32. Peers C, O DONNELL J. Potassium currents recorded in type I carotid body cells from the neonatal rat and their modulation by chemoexcitatory agents. Brain Res. 1990;522:259-66 pubmed
    ..The effect of almitrine was irreversible for up to 30 min of recording. It is concluded that the reduction of K+ currents by chemoexcitants may play a role in the mechanism of chemotransduction in the carotid body. ..
  33. Paton J, Butcher J. Cardiorespiratory reflexes in mice. J Auton Nerv Syst. 1998;68:115-24 pubmed
    ..Additionally, sodium cyanide stimulation of peripheral chemoreceptors in the WHBP produced an atropine-sensitive bradycardia and increased ..
  34. Jensen M, Nyborg N, Thomsen E. Various nitric oxide donors protect chick embryonic neurons from cyanide-induced apoptosis. Toxicol Sci. 2000;58:127-34 pubmed
  35. Cao W, Morrison S. Differential chemoreceptor reflex responses of adrenal preganglionic neurons. Am J Physiol Regul Integr Comp Physiol. 2001;281:R1825-32 pubmed
    ..of arterial chemoreceptor reflex activation, produced by inhalation of 100% N(2) or intravenous injection of sodium cyanide, on these two groups of ADR SPNs, identified antidromically in urethane-anesthetized, artificially ventilated ..
  36. Palmerini C, Marmottini F, Arienti G. Production of nitric oxide by human salivary peroxidase and by bovine lactoperoxidase. J Biochem Mol Toxicol. 2012;26:87-93 pubmed publisher
    ..We conclude that SPO and LPO transform NO(2) (-) into nitrate-forming small amounts of NO in the presence of H(2) O(2) as an intermediate or a by-product, synthesized through the peroxynitrite pathway. ..
  37. Glukhov A, Uchida K, Efimov I, Nichols C. Functional roles of KATP channel subunits in metabolic inhibition. J Mol Cell Cardiol. 2013;62:90-8 pubmed publisher
    ..2(-/-) (n=5), and SUR1(-/-) (n=6) mice during metabolic inhibition (MI, 0mM glucose+2mM sodium cyanide). After variable delay, MI led to significant shortening of APD in WT hearts...
  38. Yoneyama H, Yamamoto A, Kosaka H. Neuronal nitric oxide synthase generates superoxide from the oxygenase domain. Biochem J. 2001;360:247-53 pubmed
    ..These results demonstrate that nNOS truly catalyses superoxide formation, that this involves the oxygenase domain, and that full-length nNOS hinders the reductase domain from producing superoxide. ..
  39. Irie H, Gao J, Gaudette G, Cohen I, Mathias R, Saltman A, et al. Both metabolic inhibition and mitochondrial K(ATP) channel opening are myoprotective and initiate a compensatory sarcolemmal outward membrane current. Circulation. 2003;108 Suppl 1:II341-7 pubmed
    ..The second group of hearts was preconditioned with 2 episodes of either the metabolic inhibitor, sodium cyanide (NaCN), or the mitoK(ATP) channel opener, diazoxide...
  40. Willsky G, Malamy M. Characterization of two genetically separable inorganic phosphate transport systems in Escherichia coli. J Bacteriol. 1980;144:356-65 pubmed
    ..and the sulfhydryl reagent N-ethylmaleimide, whereas only the Pst system was very sensitive to sodium cyanide. Evidence is presented that Pi is transported as Pi or a very labile intermediate and that accumulated Pi does ..
  41. Khodorov B, Pinelis V, Vergun O, Storozhevykh T, Vinskaya N. Mitochondrial deenergization underlies neuronal calcium overload following a prolonged glutamate challenge. FEBS Lett. 1996;397:230-4 pubmed
    ..Collectively, the results obtained led us to conclude that the GLU-induced neuronal Ca2+ overload was due to the collapse of the mitochondrial potential and subsequent ATP depletion...
  42. Kobayashi M, Cheng Z, Tanaka K, Nosaka S. Is the aortic depressor nerve involved in arterial chemoreflexes in rats?. J Auton Nerv Syst. 1999;78:38-48 pubmed
    ..In conclusion, the rat ADN does not contain a functionally significant number of chemoreceptor afferent fibers, if at all, and does not appreciably contribute to generation of chemoreflexes...
  43. Sinclair C, LaRivière C, Young J, Cass C, Baldwin S, Parkinson F. Purine uptake and release in rat C6 glioma cells: nucleoside transport and purine metabolism under ATP-depleting conditions. J Neurochem. 2000;75:1528-38 pubmed
  44. Petroni A, Papini N, Blasevich M, Rise P, Galli C. Arachidonate release and c-fos expression in various models of hypoxia and hypoxia-hypoglycemia in retinoic acid differentiated neuroblastoma cells. Neurochem Int. 2002;40:255-60 pubmed
  45. Mosqueira M, Iturriaga R. Carotid body chemosensory excitation induced by nitric oxide: involvement of oxidative metabolism. Respir Physiol Neurobiol. 2002;131:175-87 pubmed
    ..Present results suggest that the chemoexcitatory effect of NO depends on the integrity of mitochondrial metabolism...
  46. Sinha D, Wang Z, Price V, Schwartz J, Lieberthal W. Chemical anoxia of tubular cells induces activation of c-Src and its translocation to the zonula adherens. Am J Physiol Renal Physiol. 2003;284:F488-97 pubmed
    ..Our findings suggest that these events contribute to the loss of the epithelial barrier function associated with chemical anoxia...
  47. Shin D, Buck L. Effect of anoxia and pharmacological anoxia on whole-cell NMDA receptor currents in cortical neurons from the western painted turtle. Physiol Biochem Zool. 2003;76:41-51 pubmed
    ..Our results show that whole-cell NMDAR currents respond differently to NaCN-induced anoxia than to the more physiologically relevant anoxia with N(2)...
  48. Wyatt C, Buckler K. The effect of mitochondrial inhibitors on membrane currents in isolated neonatal rat carotid body type I cells. J Physiol. 2004;556:175-91 pubmed
    ..These observations suggest that there is a close link between oxygen sensing and mitochondrial function in type I cells. Mechanisms that could account for this link and the actions of mitochondrial inhibitors are discussed...
  49. Xu F, Zhuang J, Zhou T, Lee L. Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigs. J Appl Physiol (1985). 2005;99:1782-8 pubmed
    ..05). When the animals were subjected to intracarotid injections of sodium cyanide (20 microg) and doxapram (2 mg) to selectively stimulate carotid chemoreceptors, the ventilatory responses ..
  50. Rainbow R, Norman R, Hudman D, Davies N, Standen N. Reduced effectiveness of HMR 1098 in blocking cardiac sarcolemmal K(ATP) channels during metabolic stress. J Mol Cell Cardiol. 2005;39:637-46 pubmed
  51. Kron M, Muller M. Impaired hippocampal Ca2+ homeostasis and concomitant K+ channel dysfunction in a mouse model of Rett syndrome during anoxia. Neuroscience. 2010;171:300-15 pubmed publisher
    ..Since cytosolic Ca(2+) levels also determine neuronal excitability and synaptic plasticity, Ca(2+) homeostasis may constitute a promising target for pharmacotherapy in RTT...
  52. Iturriaga R. Acetate enhances the chemosensory response to hypoxia in the cat carotid body in vitro in the absence of CO2-HCO3-. Biol Res. 1996;29:237-43 pubmed
    ..It is suggested that that intracellular acidosis induced by acetate contributes to this potentiation by correcting the alkaline pHi caused by the absence of HCO3-(-)HCO2 in the perfusate...
  53. Sugito K, Tatsumi K, Igari H, Kasahara Y, Tani T, Kimura H, et al. Role of carotid body in pressure response of pulmonary circulation in rats. Respir Physiol. 1998;111:283-93 pubmed
    ..Selective carotid body stimulation by the intra-carotid injection of sodium cyanide (NaCN) in normoxia elicited an immediate but transient increase in PAP and Q before and after bilateral ..
  54. Ravi K, Singh M. Reflex changes in heart rate during chemoreceptor stimulation in monkeys. Can J Physiol Pharmacol. 1999;77:787-95 pubmed the stimulation of arterial chemoreceptors by apneic asphyxia and left atrial - intracarotid injections of sodium cyanide were investigated in anesthetized artificially ventilated and paralysed monkeys...
  55. Masuhara K, Ohmichi M, Kurachi H, Tasaka K, Kanzaki T, Kimura A, et al. Involvement of extracellular signal-regulated protein kinase in gliosis induced during recovery from metabolic inhibition. Biochem Biophys Res Commun. 2000;267:892-6 pubmed
    ..These results suggest that ERK is involved in gliosis during the recovery phase from MI and may play a role in the etiology of periventricular leukomalacia...
  56. Xu F, Frazier D. Modulation of respiratory motor output by cerebellar deep nuclei in the rat. J Appl Physiol (1985). 2000;89:996-1004 pubmed
    ..neurons in respiratory chemoreflexes, ventilation with hypercapnic gases mixture and intravenous injection of sodium cyanide were applied before and after CDN lesions induced by kainic acid...
  57. Jensen M, Ahlemeyer B, Ravati A, Thakur P, Mennel H, Krieglstein J. Preconditioning-induced protection against cyanide-induced neurotoxicity is mediated by preserving mitochondrial function. Neurochem Int. 2002;40:285-93 pubmed
    ..In this study, primary cultures of chick embryonic neurons were used to characterize sodium cyanide (NaCN)-induced cell death and to investigate the mechanism of NaCN-mediated preconditioning...
  58. Matsumoto N, Noda E, Nabekura J. Run down of GABAergic depolarization during metabolic inhibition of rat hippocampal CA1 neurons. Life Sci. 2006;79:1021-6 pubmed
  59. Reichel V, Miller D, Fricker G. Texas Red transport across rat and dogfish shark (Squalus acanthias) choroid plexus. Am J Physiol Regul Integr Comp Physiol. 2008;295:R1311-9 pubmed publisher
    ..In shark, neither PKA nor PKC activation specifically affected TR transport. Thus, rat and dogfish shark CP transport TR but do so using different basic mechanisms that respond to different regulatory signals...
  60. Sato H, Takeo T, Liu Q, Nakano K, Osanai T, Suga S, et al. Hydrogen peroxide mobilizes Ca2+ through two distinct mechanisms in rat hepatocytes. Acta Pharmacol Sin. 2009;30:78-89 pubmed publisher
    ..Hydrogen peroxide (H2O2) is produced during liver transplantation. Ischemia/reperfusion induces oxidation and causes intracellular Ca2+ overload, which harms liver cells. Our goal was to determine the precise mechanisms of these processes...
  61. Takakura A, Colombari E, Menani J, Moreira T. Ventrolateral medulla mechanisms involved in cardiorespiratory responses to central chemoreceptor activation in rats. Am J Physiol Regul Integr Comp Physiol. 2011;300:R501-10 pubmed publisher
  62. Hayashi H, Miyata H, Terada H, Satoh H, Katoh H, Nakamura T, et al. Ca2+ waves and intracellular Ca2+ concentration in guinea pig and rat myocytes. Jpn Heart J. 1994;35:673-82 pubmed
    ..during the control perfusion period, but could be induced by the addition of strophanthidin (100 microM) or sodium cyanide (NaCN: 2 mM) to the perfusate...
  63. Alcayaga J, Iturriaga R, Ramirez J, Readi R, Quezada C, Salinas P. Cat carotid body chemosensory responses to non-hypoxic stimuli are inhibited by sodium nitroprusside in situ and in vitro. Brain Res. 1997;767:384-7 pubmed
    ..The present results suggest that chemosensory responses induced by cyanide and nicotine are reduced by increased nitric oxide content, similarly to the hypoxic chemosensory responses...
  64. Mattson M, Zhu H, Yu J, Kindy M. Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis. J Neurosci. 2000;20:1358-64 pubmed
    ..The data further suggest that drugs that stabilize endoplasmic reticulum calcium homeostasis may prove effective in suppressing the neurodegenerative process in AD patients...
  65. Moreno Sanchez R, Covian R, Jasso Chávez R, Rodriguez Enriquez S, Pacheco Moisés F, Torres Marquez M. Oxidative phosphorylation supported by an alternative respiratory pathway in mitochondria from Euglena. Biochim Biophys Acta. 2000;1457:200-10 pubmed
    ..Based on these results, a model of the respiratory chain of Euglena mitochondria is proposed, in which a quinol-cytochrome c oxidoreductase resistant to antimycin, and a quinol oxidase resistant to antimycin and cyanide are included...
  66. Pereira I, LeGall J, Xavier A, Teixeira M. Characterization of a heme c nitrite reductase from a non-ammonifying microorganism, Desulfovibrio vulgaris Hildenborough. Biochim Biophys Acta. 2000;1481:119-30 pubmed
    ..The possible role of this enzyme in the detoxification of nitrite and/or in the reduction of sulfite is discussed...
  67. Matsumoto N, Komiyama S, Akaike N. Pre- and postsynaptic ATP-sensitive potassium channels during metabolic inhibition of rat hippocampal CA1 neurons. J Physiol. 2002;541:511-20 pubmed
    ..These results confirm the presence of KATP channels on both the pre- and postsynaptic membranes but indicate that the channels have significantly different sensitivities to metabolic inhibition...
  68. Khodorov B, Storozhevykh T, Surin A, Yuryavichyus A, Sorokina E, Borodin A, et al. The leading role of mitochondrial depolarization in the mechanism of glutamate-induced disruptions in Ca2+ homeostasis. Neurosci Behav Physiol. 2002;32:541-7 pubmed
  69. Emerson J, Coulter E, Phillips R, Kurtz D. Kinetics of the superoxide reductase catalytic cycle. J Biol Chem. 2003;278:39662-8 pubmed
    ..These results provide quantitative support for previous suggestions that, in times of oxidative stress, SORs efficiently divert intracellular reducing equivalents to superoxide...
  70. Samuilov V, Lagunova E, Kiselevsky D, Dzyubinskaya E, Makarova Y, Gusev M. Participation of chloroplasts in plant apoptosis. Biosci Rep. 2003;23:103-17 pubmed
    ..e., ROS and reduced plastoquinone of the photosynthetic electron transfer chain. As to reduction of ubiquinone in the mitochondrial respiratory chain, it seems to be antiapoptotic for the guard cell...
  71. Solomon I. Glutamate neurotransmission is not required for, but may modulate, hypoxic sensitivity of pre-Bötzinger complex in vivo. J Neurophysiol. 2005;93:1278-84 pubmed
    ..To test this possibility, the effects of focal pre-BötC hypoxia [induced by sodium cyanide (NaCN)] were examined before and after blockade of ionotropic EAA receptors [using kynurenic acid (KYN)] in ..
  72. Hahn N, Meischl C, Wijnker P, Musters R, Fornerod M, Janssen H, et al. NOX2, p22phox and p47phox are targeted to the nuclear pore complex in ischemic cardiomyocytes colocalizing with local reactive oxygen species. Cell Physiol Biochem. 2011;27:471-8 pubmed publisher
    ..g. under ischemia or high concentrations of homocysteine, is an important step in the induction of apoptosis in these cells. Here this ischemia-induced nuclear targeting and activation of NOX2 was specified in cardiomyocytes...
  73. Latha M, Borowitz J, Yim G, Kanthasamy A, Isom G. Plasma membrane hyperpolarization by cyanide in chromaffin cells: role of potassium channels. Arch Toxicol. 1994;68:370-4 pubmed
    ..These findings suggest that cyanide mobilizes Ca2+ from intracellular stores which leads to hyperpolarization via the activation of Ca2+ sensitive K+ channels...
  74. Longo V, Liou L, Valentine J, Gralla E. Mitochondrial superoxide decreases yeast survival in stationary phase. Arch Biochem Biophys. 1999;365:131-42 pubmed
    ..These results raise the possibility that similar processes may occur in higher eukaryotes...
  75. Golanov E, Ruggiero D, Reis D. A brainstem area mediating cerebrovascular and EEG responses to hypoxic excitation of rostral ventrolateral medulla in rat. J Physiol. 2000;529 Pt 2:413-29 pubmed
  76. Inoue M, Fujishiro N, Imanaga I, Sakamoto Y. Role of ATP decrease in secretion induced by mitochondrial dysfunction in guinea-pig adrenal chromaffin cells. J Physiol. 2002;539:145-55 pubmed
    ..Thus, mitochondrial inhibition rapidly decreases [ATP] and the mitochondrial dysfunction-induced secretion is not due to ROS generation or to mitochondrial depolarization, but is possibly mediated by a decrease in ATP...
  77. Solomon I. Modulation of gasp frequency by activation of pre-Bötzinger complex in vivo. J Neurophysiol. 2002;87:1664-8 pubmed
    ..of chemical stimulation of neurons (DL-homocysteic acid; DLH; 10 mM; < or =20 nl) and focal hypoxia (sodium cyanide; NaCN; 1 mM; < or =20 nl) in the pre-BötC on hypoxia-induced gasping in chloralose-anesthetized, ..
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