ruthenium compounds


Summary: Inorganic compounds that contain ruthenium as an integral part of the molecule.

Top Publications

  1. Pereira A, Paulo M, Araújo A, Rodrigues G, Bendhack L. Nitric oxide synthesis and biological functions of nitric oxide released from ruthenium compounds. Braz J Med Biol Res. 2011;44:947-57 pubmed
    ..In addition, the involvement of the nitrite molecule as an endogenous NO reservoir engaged in vasodilatation will be described...
  2. Brabec V, Novakova O. DNA binding mode of ruthenium complexes and relationship to tumor cell toxicity. Drug Resist Updat. 2006;9:111-22 pubmed
    ..Due to differing ligand geometry between their complexes, ruthenium compounds bind to DNA affecting its conformation differently than cisplatin and its analogues...
  3. Zhang J, Song S, Zhang L, Wang L, Wu H, Pan D, et al. Sequence-specific detection of femtomolar DNA via a chronocoulometric DNA sensor (CDS): effects of nanoparticle-mediated amplification and nanoscale control of DNA assembly at electrodes. J Am Chem Soc. 2006;128:8575-80 pubmed
    ..In addition, this novel DNA sensor showed fairly good reproducibility, stability, and reusability...
  4. Wu C, Wu D, Liu X, Guoyiqibayi G, Guo D, Lv G, et al. Ligand-based neutral ruthenium(II) arene complex: selective anticancer action. Inorg Chem. 2009;48:2352-4 pubmed publisher
  5. Levina A, Mitra A, Lay P. Recent developments in ruthenium anticancer drugs. Metallomics. 2009;1:458-70 pubmed publisher
    ..New approaches to metabolic studies, such as X-ray absorption spectroscopy and X-ray fluorescence microscopy, are required to provide further mechanistic insights, which could lead to the rational design of improved Ru anticancer drugs...
  6. Abdallah Y, Kasseckert S, Iraqi W, Said M, Shahzad T, Erdogan A, et al. Interplay between Ca2+ cycling and mitochondrial permeability transition pores promotes reperfusion-induced injury of cardiac myocytes. J Cell Mol Med. 2011;15:2478-85 pubmed publisher
    ..The interplay between Ca(2+) cycling and MPTP promotes the reperfusion-induced cardiomyocyte hypercontracture and necrosis. Mitochondrial ROS formation is a result rather than a cause of MPTP opening...
  7. Hashitani H, Hashiatni H, Lang R, Suzuki H. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra. Br J Pharmacol. 2010;161:680-94 pubmed publisher
  8. Bertoncello P, Dennany L, Forster R, Unwin P. Nafion-tris(2-2'-bipyridyl)ruthenium(II) Ultrathin Langmuir-Schaefer films: redox catalysis and electrochemiluminescent properties. Anal Chem. 2007;79:7549-53 pubmed
    ..Concomitant electrochemiluminescence (ECL) was demonstrated highlighting the potential of this material for sensing applications...
  9. Kannurpatti S, Biswal B. Mitochondrial Ca2+ uniporter blockers influence activation-induced CBF response in the rat somatosensory cortex. J Cereb Blood Flow Metab. 2008;28:772-85 pubmed
    ..We conclude that mitochondrial calcium signaling through the MCU mediates neural activation-induced CBF response in vivo...

More Information


  1. Fluegge D, Moeller L, Cichy A, Gorin M, Weth A, Veitinger S, et al. Mitochondrial Ca(2+) mobilization is a key element in olfactory signaling. Nat Neurosci. 2012;15:754-62 pubmed publisher
    ..Moreover, we describe activity-dependent recruitment of mitochondria to olfactory knobs, a mechanism that provides a context-dependent tool for OSNs to maintain cellular homeostasis and signaling integrity...
  2. Grubb M, Wackerbarth H, Wengel J, Ulstrup J. Direct imaging of hexaamine-ruthenium(III) in domain boundaries in monolayers of single-stranded DNA. Langmuir. 2007;23:1410-3 pubmed
    ..Together with the electrochemical data that show a negative redox potential shift for RuHex adsorbed to DNA strands, this strongly suggests that RuHex binds only to the exposed phosphate groups in the DNA backbone...
  3. Malina J, Novakova O, Keppler B, Alessio E, Brabec V. Biophysical analysis of natural, double-helical DNA modified by anticancer heterocyclic complexes of ruthenium(III) in cell-free media. J Biol Inorg Chem. 2001;6:435-45 pubmed
    ..Interestingly, Na[trans-Cl4Im(Me2SO)RuIII] binds to DNA considerably faster than the other two ruthenium compounds and cisplatin...
  4. Matlib M, Zhou Z, Knight S, Ahmed S, Choi K, Krause Bauer J, et al. Oxygen-bridged dinuclear ruthenium amine complex specifically inhibits Ca2+ uptake into mitochondria in vitro and in situ in single cardiac myocytes. J Biol Chem. 1998;273:10223-31 pubmed
    ..We conclude that Ru360 specifically blocks Ca2+ uptake into mitochondria and can be used in intact cells...
  5. Hartinger C, Zorbas Seifried S, Jakupec M, Kynast B, Zorbas H, Keppler B. From bench to bedside--preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A). J Inorg Biochem. 2006;100:891-904 pubmed
    ..In this review, the preclinical and early clinical development of KP1019 - from bench to bedside - is recapitulated...
  6. Mosi R, Seguin B, Cameron B, Amankwa L, Darkes M, Fricker S. Mechanistic studies on AMD6221: a ruthenium-based nitric oxide scavenger. Biochem Biophys Res Commun. 2002;292:519-29 pubmed
  7. Bădoiu A, Bernardinelli G, Besnard C, Kündig E. Asymmetric ruthenium-catalyzed 1,4-additions of aryl thiols to enones. Org Biomol Chem. 2010;8:193-200 pubmed publisher
    ..The absolute configuration of the major products indicates enones to react in the syn-s-trans orientation. Models based on X-ray structures of the Ru complexes can be used to rationalize selectivity. ..
  8. Giovagnini L, Mancinetti E, Ronconi L, Sitran S, Marchio L, Castagliuolo I, et al. Preliminary chemico-biological studies on Ru(III) compounds with S-methyl pyrrolidine/dimethyl dithiocarbamate. J Inorg Biochem. 2009;103:774-82 pubmed publisher
    ..The crystal structure of mer-[Ru(DMDTM)(DMSO)Cl(3)] has been also determined by X-ray crystallography. In vitro cytotoxic activity of all the synthesized complexes was eventually evaluated on some selected human tumor cell lines...
  9. Gligorijević N, Aranđelović S, Filipović L, Jakovljević K, Janković R, Grgurić Sipka S, et al. Picolinate ruthenium(II)-arene complex with in vitro antiproliferative and antimetastatic properties: comparison to a series of ruthenium(II)-arene complexes with similar structure. J Inorg Biochem. 2012;108:53-61 pubmed publisher
  10. Golfeto C, Von Poelhsitz G, Selistre de Araujo H, de Araujo M, Ellena J, Castellano E, et al. Synthesis, characterization and cytotoxic activities of the [RuCl2(NO)(dppp)(L)]PF6 complexes. J Inorg Biochem. 2010;104:489-95 pubmed publisher
    The synthesis and characterization of ruthenium compounds of the type [RuCl(2)(NO)(dppp)(L)]PF(6) [dppp=1,3-bis(diphenylphosphino)propane; L=pyridine, 4-methylpyridine, 4-phenylpyridine and dimethyl sulfoxide] are described...
  11. Will J, Kyas A, Sheldrick W, Wolters D. Identification of (eta6-arene)ruthenium(II) protein binding sites in E. coli cells by combined multidimensional liquid chromatography and ESI tandem mass spectrometry: specific binding of [(eta6-p-cymene)RuCl2 (DMSO)] to stress-regulated proteins and. J Biol Inorg Chem. 2007;12:883-94 pubmed
    ..Aspartate carboxylate functions were identified as the probable Ru binding sites in cspC, ppiD and dinG, and threonine and lysine side chains in osmY and sucC, respectively. ..
  12. Lin C, Noked M, Kozen A, Liu C, Zhao O, Gregorczyk K, et al. Solid Electrolyte Lithium Phosphous Oxynitride as a Protective Nanocladding Layer for 3D High-Capacity Conversion Electrodes. ACS Nano. 2016;10:2693-701 pubmed publisher
    ..Furthermore, even at very low lithiation potential (0.05 V), the LiPON-protected electrode largely reduces the formation of a solid electrolyte interphase. ..
  13. da Silva R, Marchesi M, Khin C, Lunardi C, Bendhack L, Ford P. Photoinduced electron transfer between the cationic complexes Ru(NH3)5pz2+ and trans-RuCl([15]aneN4)NO2+ mediated by phosphate ion: visible light generation of nitric oxide for biological targets. J Phys Chem B. 2007;111:6962-8 pubmed
    ..Reexamination of the cyclic voltammetry of Rupz2+ showed that the electrochemical behavior of this species is also affected by the presence of the phosphate buffer. ..
  14. Demoro B, Rossi M, Caruso F, Liebowitz D, Olea Azar C, Kemmerling U, et al. Potential mechanism of the anti-trypanosomal activity of organoruthenium complexes with bioactive thiosemicarbazones. Biol Trace Elem Res. 2013;153:371-81 pubmed publisher
    ..Because of genomic similarities between trypanosomatides, these ruthenium compounds were evaluated, in the current work, on Trypanosoma cruzi, the parasite responsible of American ..
  15. Medina S, Domínguez G, Pérez Castells J. Efficient generation of pyridines by ruthenium carbene mediated [2 + 2 + 2] cyclotrimerization. Org Lett. 2012;14:4982-5 pubmed publisher
    ..Both terminal and internal alkynes give the reaction using this experimental procedure. ..
  16. Patrick C, Giustino F. Quantitative analysis of valence photoemission spectra and quasiparticle excitations at chromophore-semiconductor interfaces. Phys Rev Lett. 2012;109:116801 pubmed
    ..This case study sets a new standard in the interpretation of photoemission spectroscopy at complex chromophore-semiconductor interfaces. ..
  17. Liang W, Wang K, Chen L, Ruan L, Sui L. Variation of algal viability during electrochemical disinfection using Ti/RuO2 electrodes. Water Sci Technol. 2011;64:162-70 pubmed
    ..However, decrease of the inactivation effect by adding ascorbic acid as an oxidant scavenger indicated that the reactive oxygen species, especially *OH radicals, played an important role for chlorine-free electrolytes. ..
  18. Mola J, Mas Marzá E, Sala X, Romero I, Rodriguez M, Viñas C, et al. Ru-hbpp-based water-oxidation catalysts anchored on conducting solid supports. Angew Chem Int Ed Engl. 2008;47:5830-2 pubmed publisher
  19. Wambach T, Lenczyk C, Patrick B, Fryzuk M. Synthesis and coordination chemistry of tridentate (PNN) amine enamido phosphine ligands with ruthenium. Dalton Trans. 2016;45:5583-9 pubmed publisher
    ..The reactivity of both amine-enamido-phosphine ruthenium compounds with benzyl alcohol establishes that the complexes are catalyst precursors for acceptorless dehydrogenation ..
  20. Zhang C, Liu Z, Sun Y, Shen Y, Chen Y, Liu Y, et al. Electronic structures and absorption properties of three kinds of ruthenium dye sensitizers containing bipyridine-pyrazolate for solar cells. Spectrochim Acta A Mol Biomol Spectrosc. 2011;79:1843-8 pubmed publisher
  21. Claessens N, Pierard F, Bresson C, Moucheron C, Kirsch De Mesmaeker A. Optically active Ru(II) complexes with a chiral Tröger's base ligand and their interactions with DNA. J Inorg Biochem. 2007;101:987-96 pubmed
    ..The affinity constant for the stereoisomer Delta-S-2 is 10(2) higher than that for Lambda-S-2 and rac-[Ru(phen)3]2+. ..
  22. Matera S, Meskine H, Reuter K. Adlayer inhomogeneity without lateral interactions: rationalizing correlation effects in CO oxidation at RuO2(110) with first-principles kinetic Monte Carlo. J Chem Phys. 2011;134:064713 pubmed publisher
    ..This deficiency is traced back to the inability to account for the vacancy pair formation that is kinetically driven by the ongoing reactions. ..
  23. Fang K, Chang W, Wang S, Su M, Wu M. Arachidonic acid induces both Na+ and Ca2+ entry resulting in apoptosis. J Neurochem. 2008;104:1177-89 pubmed
    ..The NSCC may therefore act as a potential neuronal death pore which is activated by AA accumulation under pathological conditions. ..
  24. Mari C, Gasser G. Lightening up Ruthenium Complexes to Fight Cancer?. Chimia (Aarau). 2015;69:176-81 pubmed
    ..Herein, we report on our findings in the optimization of Ru(II) polypyridyl complexes as PDT and PACT agents for the potential treatment of cancer and, interestingly, also of bacterial infections. ..
  25. Łomzik M, Mazuryk O, Rutkowska Zbik D, Stochel G, Gros P, Brindell M. New ruthenium compounds bearing semicarbazone 2-formylopyridine moiety: Playing with auxiliary ligands for tuning the mechanism of biological activity. J Inorg Biochem. 2017;175:80-91 pubmed publisher
    ..Despite this the apoptosis induced by Ru2 was caspase-independent. All these findings point to a pronounced role of auxiliary ligands in tuning the mode of biological activity. ..
  26. Berger I, Hanif M, Nazarov A, Hartinger C, John R, Kuznetsov M, et al. In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands. Chemistry. 2008;14:9046-57 pubmed publisher
    ..In vitro studies revealed that the 3,5,6-bicyclophosphite-1,2-O-cyclohexylidene-alpha-D-glucofuranoside complex is the most cytotoxic compound in human cancer cell lines (IC50 values from 30 to 300 microM depending on the cell line). ..
  27. Scolaro C, Hartinger C, Allardyce C, Keppler B, Dyson P. Hydrolysis study of the bifunctional antitumour compound RAPTA-C, [Ru(eta6-p-cymene)Cl2(pta)]. J Inorg Biochem. 2008;102:1743-8 pubmed publisher
    ..Hydrolysis is suppressed at high chloride concentrations. These results have important implications on the mode of action of the RAPTA drug candidates. ..
  28. Tamasi G, Curci M, Berrettini F, Justice N, Sega A, Chiasserini L, et al. [RuII(NO+)]3+-core complexes with 4-methyl-pyrimidine and ethyl-isonicotinate: synthesis, X-ray structure, spectroscopy, and computational and NO-release studies upon UVA irradiation. J Inorg Biochem. 2008;102:1874-84 pubmed publisher
    ..Under irradiation at 366 nm several solutions of the title compounds deliver NO via first order processes. Visible light (420-700 nm) does not produce significant NO release from CH(2)Cl(2) and CH(3)CN solutions within 24h. ..
  29. Dougan S, Habtemariam A, McHale S, Parsons S, Sadler P. Catalytic organometallic anticancer complexes. Proc Natl Acad Sci U S A. 2008;105:11628-33 pubmed publisher
    ..A redox cycle involving glutathione attack on the azo bond of coordinated azopyridine is proposed. Such ligand-based redox reactions provide new concepts for the design of catalytic drugs. ..
  30. Zia M, Siddiqui T, Ali S, Rehman A, Ahsan H, Khan F. Chemotherapeutic drugs and plasma proteins: Exploring new dimensions. Curr Protein Pept Sci. 2017;: pubmed publisher
    ..Insight into varied anticancer drug- protein interaction will go a long way in understanding in totality of the mechanism of action of any anticancer drug and its possible effects/side effects...
  31. Auzias M, Therrien B, Süss Fink G, Stepnicka P, Ang W, Dyson P. Ferrocenoyl pyridine arene ruthenium complexes with anticancer properties: synthesis, structure, electrochemistry, and cytotoxicity. Inorg Chem. 2008;47:578-83 pubmed
    ..Cyclic voltammetry revealed a good correlation of the RuII/RuIII redox potentials of 1-4 and the number of alkyl substituents in the arene ligand. ..
  32. Bharanidharan D, Thiyagarajan S, Gautham N. Hexammineruthenium(III) ion interactions with Z-DNA. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007;63:1008-13 pubmed
    ..54 A resolution. Strong ion interactions with the adenine base induce a tautomeric shift from the amino to the imino form. Consequently, the A.T base pairing is disrupted. This structural study may be relevant to metal toxicity. ..
  33. Jia J, Kato D, Kurita R, Sato Y, Maruyama K, Suzuki K, et al. Structure and electrochemical properties of carbon films prepared by a electron cyclotron resonance sputtering method. Anal Chem. 2007;79:98-105 pubmed
    ..25 and 1.12 V vs Ag/AgCl, respectively. The film is very stable for continuous voltammetry measurements in 10 microM bisphenol A, which usually fouls the electrode surface with oxidation products. ..
  34. Joshi T, Patra M, Spiccia L, Gasser G. Di-heterometalation of thiol-functionalized peptide nucleic acids. Artif DNA PNA XNA. 2013;4:11-8 pubmed publisher
  35. Wang Y, Meng S, Song Y, Zhong W, Jiang J, Chen S, et al. Fluorescence optical fibre sensor provides accurate continuous oxygen detection in rabbit model with acute lung injury. Respirology. 2010;15:99-106 pubmed publisher
  36. Piccialli V, Zaccaria S, Centore R, Tuzi A, Borbone N, Oliviero G. Isolation of a bis-iodurated tetra-THF as a trace product from the oxidation of squalene with RuO? and its double ring expansion to a novel bis-THF-bis-THP compound. Molecules. 2011;16:5362-73 pubmed publisher
    ..A bidirectional double oxidative bis-cyclization is invoked to explain the formation of this compound. The isolated substance was successfully subjected to a double rearrangement-ring expansion to give a novel bis-THF-bis-THP compound. ..
  37. Polyansky D, Cabelli D, Muckerman J, Fujita E, Koizumi T, Fukushima T, et al. Photochemical and radiolytic production of an organic hydride donor with a Ru(II) complex containing an NAD+ model ligand. Angew Chem Int Ed Engl. 2007;46:4169-72 pubmed
  38. Randviir E, Brownson D, Gómez Mingot M, Kampouris D, Iniesta J, Banks C. Electrochemistry of Q-graphene. Nanoscale. 2012;4:6470-80 pubmed
    ..Consequently there is potential for this new member of the graphene family to be beneficially utilised in various electrochemical applications. ..
  39. Düzgün A, Imran H, Levon K, Rius F. Protein detection with potentiometric aptasensors: a comparative study between polyaniline and single-walled carbon nanotubes transducers. ScientificWorldJournal. 2013;2013:282756 pubmed publisher
    ..The sensitivity is calculated as 2.97 mV/decade and 8.03 mV/decade for the PANI and SWCNTs aptasensors, respectively. These results are in accordance with the higher surface density of the aptamers in the SWCNT potentiometric sensor. ..
  40. Lu Y. Preparation of novel polypyridyl ruthenium complex polymers with high sensitivity for electrogenerated chemiluminescence via copolymerization. Photochem Photobiol Sci. 2010;9:392-7 pubmed publisher
    ..The significant enhancement of ECL and improvement in making a stable film could be expected to lead to an applicable immobilized immunoassay technology via ECL. ..
  41. Liu D, Xin Y, He X, Yin X. A sensitive, non-damaging electrochemiluminescent aptasensor via a low potential approach at DNA-modified gold electrodes. Analyst. 2011;136:479-85 pubmed publisher
    ..The protocol exhibited a promising platform for sensitive bioassay and could be further applied for the development of other low potential ECL sensing systems. ..
  42. Cheng J, Zhou J, Goodenough J. Lattice effects on ferromagnetism in perovskite ruthenates. Proc Natl Acad Sci U S A. 2013;110:13312-5 pubmed publisher
  43. Terashima T, Nomura A, Ouchi M, Sawamoto M. Efficient and robust star polymer catalysts for living radical polymerization: cooperative activation in microgel-core reactors. Macromol Rapid Commun. 2012;33:833-41 pubmed publisher
    ..As a result, the in-core pseudo hetero P,N-chelation of the ruthenium complexes not only showed high activity for methyl methacrylate but also high tolerance to unprotected methacrylic acid. ..
  44. Westerlund F, Pierard F, Eng M, Norden B, Lincoln P. Enantioselective luminescence quenching of DNA light-switch [Ru(phen)2dppz]2+ by electron transfer to structural homologue [Ru(phendione)2dppz]2+. J Phys Chem B. 2005;109:17327-32 pubmed
    ..The very slow electron transfer from [Ru(phen)(2)dppz](2+) to [Ru(phendione)(2)dppz](2+), compared to the case when [Rh(phi)(2)phen](3+) is the acceptor, can be explained by a much smaller driving free-energy difference. ..
  45. Turel I, Kljun J, Perdih F, Morozova E, Bakulev V, Kasyanenko N, et al. First ruthenium organometallic complex of antibacterial agent ofloxacin. Crystal structure and interactions with DNA. Inorg Chem. 2010;49:10750-2 pubmed publisher
    ..Our experiments revealed that binding of the title complex to DNA occurs also if guanine N7 is protonated. AFM has shown that the title complex provokes DNA shrinkage. Preliminary biological tests have also been performed...
  46. Gan G, Chao H, Cai X, Jiang Z, Li H. Condensation and salt-induced decondensation of DNA upon incorporation of a V-shaped luminescent [Ru2(bpy)4(mbpibH2)](4+). J Inorg Biochem. 2013;129:9-14 pubmed publisher
    ..The results from this study offer an effective method to control the condensation and decondensation of DNA upon incorporation of luminescent concentrators. ..
  47. Onitsuka K, Okuda H, Sasai H. Regio- and enantioselective o-allylation of phenol and alcohol catalyzed by a planar-chiral cyclopentadienyl ruthenium complex. Angew Chem Int Ed Engl. 2008;47:1454-7 pubmed publisher
  48. Garcia T, Revenga Parra M, Abruña H, Pariente F, Lorenzo E. Single-mismatch position-sensitive detection of DNA based on a bifunctional ruthenium complex. Anal Chem. 2008;80:77-84 pubmed
    ..pylori, due to the selective interaction of this bifunctional ruthenium complex with dsDNA...
  49. Radjenovic J, Bagastyo A, Rozendal R, Mu Y, Keller J, Rabaey K. Electrochemical oxidation of trace organic contaminants in reverse osmosis concentrate using RuO2/IrO2-coated titanium anodes. Water Res. 2011;45:1579-86 pubmed publisher
  50. Gong L, Wenzel M, Meggers E. Chiral-auxiliary-mediated asymmetric synthesis of ruthenium polypyridyl complexes. Acc Chem Res. 2013;46:2635-44 pubmed publisher
    ..Our approach should serve as a blueprint for the asymmetric synthesis of different classes of ruthenium complexes and chiral coordination complexes of other metals. ..
  51. Lin Y, Huang Y, Zheng W, Wang F, Habtemariam A, Luo Q, et al. Organometallic ruthenium anticancer complexes inhibit human glutathione-S-transferase ?. J Inorg Biochem. 2013;128:77-84 pubmed publisher
    ..The binding of the ruthenium arene complexes to Cys102 or Met92 disrupts the dimer interface which is an essential structural feature for the proper functioning of GST?, perhaps also contributing to the inhibition of GST?...
  52. Leitão Junior A, Campos R, Cerqueira J, Fonteles M, Santos C, de Nucci G, et al. Relaxant effect of a metal-based drug in human corpora cavernosa and its mechanism of action. Int J Impot Res. 2016;28:20-4 pubmed publisher
    ..FOR0811 completely relaxes HCC by a sGC-cGMP-dependent mechanism and can be a lead compound in the development of new stable NO donors. ..
  53. Grubb M, Wackerbarth H, Ulstrup J. Identification of single-strand DNA by in situ scanning tunneling microscopy. J Am Chem Soc. 2006;128:7734-5 pubmed
    ..When compared with previous results, the data also suggest that the mechanism of domain formation of the immobilized DNA is independent of the sequence...
  54. Jain A, Slebodnick C, Winkel B, Brewer K. Enhanced DNA photocleavage properties of Ru(II) terpyridine complexes upon incorporation of methylphenyl substituted terpyridine and/or the polyazine bridging ligand dpp (2,3-bis(2-pyridyl)pyrazine). J Inorg Biochem. 2008;102:1854-61 pubmed publisher
    ..16; [(tpy)RuCl(dpp)](PF(6)), logP=-1.27). The heteroleptic complexes photocleave DNA more efficiently than the homoleptic complexes, with the greatest activity being observed for the newly prepared [(MePhtpy)RuCl(dpp)](PF(6)) complex...
  55. Reyes R, Parpura V. Mitochondria modulate Ca2+-dependent glutamate release from rat cortical astrocytes. J Neurosci. 2008;28:9682-91 pubmed publisher
    ..These observations suggest that, in addition to the activity of ER and plasma membrane ion channels, mitochondria modulate Ca(2+)(cyt) dynamics in astrocytes and play a role in Ca(2+)-dependent glutamate release from astrocytes...
  56. Gabrielsson A, Towrie M, Zalis S, Vlcek A. Nanosecond CO photodissociation and excited-state character of [Ru(X)(X')(CO)2(N,N'-diisopropyl-1,4-diazabutadiene)] (X=X'=Cl or I; X=Me, X'=I; X=SnPh3, X'=Cl) studied by time-resolved infrared spectroscopy and DFT calculations. Inorg Chem. 2008;47:4236-42 pubmed publisher
    ..2 ns lifetime and without any observable intermediate. To our knowledge, this is the first example of a "slow" CO dissociation from a thermally equilibrated triplet charge-transfer excited state...
  57. Xing B, Yin X. Novel poly-dopamine adhesive for a halloysite nanotube-Ru(bpy)(3)2+ electrochemiluminescent sensor. PLoS ONE. 2009;4:e6451 pubmed publisher
    ..The results indicate that halloysite nanotubes have a high loading capacity for Ru(bpy)(3) (2+) and that dopamine is suitable for the preparation of modified electrodes...
  58. Shakkthivel P, Chen S. Simultaneous determination of ascorbic acid and dopamine in the presence of uric acid on ruthenium oxide modified electrode. Biosens Bioelectron. 2007;22:1680-7 pubmed
    ..8mM of AA and DA was carried out at free of electrode fouling. Interestingly, the regeneration of used RME electrode even after many consequent analysis, 100% was obtained...
  59. Benini P, McGarvey B, Franco D. Functionalization of PAMAM dendrimers with [Ru(III)(edta)(H2O)](-). Nitric Oxide. 2008;19:245-51 pubmed publisher
    ..1+/-0.7 x 10(-3)s(-1) (pH 1.0, mu=0.2 mol/L, CF3COOH/NaCF3COO, 25 degrees C). The G(x)/RuNO species induced a relaxing effect in aortic rings denuded of endothelium and exhibited in vitro assay trypanocidal activity...
  60. Cristiano M, Cardoso D, da Silva Paula M, Costa Campos L. Antinociceptive effect of a ruthenium complex in mice. Auton Autacoid Pharmacol. 2008;28:103-8 pubmed publisher
    ..From this perspective, further experimental studies will be useful to understand the effect of these compounds on NO and the relationship between prostaglandin and NO biosynthesis...
  61. Rajapakse C, Martinez A, Naoulou B, Jarzecki A, Suárez L, Deregnaucourt C, et al. Synthesis, characterization, and in vitro antimalarial and antitumor activity of new ruthenium(II) complexes of chloroquine. Inorg Chem. 2009;48:1122-31 pubmed publisher
  62. Venkateswaran R, Mague J, Balakrishna M. Ruthenium(II) complexes containing bis(2-(diphenylphosphino)phenyl) ether and their catalytic activity in hydrogenation reactions. Inorg Chem. 2007;46:809-17 pubmed
    ..The structures of the complexes 1-5, 7, and 8 are confirmed by X-ray crystallography. The catalytic activity of these complexes for the hydrogenation of styrene is studied...
  63. Evans S, Grigoryan A, Szalai V. Oxidation of guanine in double-stranded DNA by [Ru(bpy)2dppz]Cl2 in cationic reverse micelles. Inorg Chem. 2007;46:8349-61 pubmed
    ..The observed change in the G oxidation mechanism from a one-electron process in buffer to mostly 1O2 in RMs illustrates the importance of both DNA structure and DNA environment on the chemistry of G oxidation...
  64. Marquele Oliveira F, Santana D, Taveira S, Vermeulen D, de Oliveira A, da Silva R, et al. Development of nitrosyl ruthenium complex-loaded lipid carriers for topical administration: improvement in skin stability and in nitric oxide release by visible light irradiation. J Pharm Biomed Anal. 2010;53:843-51 pubmed publisher
    ..NRC-loaded SLN performs well enough at releasing and protecting NO degradation in vitro that it is a promising carrier for topical delivery of NO...
  65. Tarmann L, Wackernagel W, Ivastinovic D, Schneider M, Winkler P, Langmann G. Tumor parameters predict the risk of side effects after ruthenium-106 plaque brachytherapy of uveal melanomas. PLoS ONE. 2017;12:e0183833 pubmed publisher
    ..To report on radiation-related side effects and complications after ruthenium-106 plaque brachytherapy of uveal melanomas...
  66. Raghu S, Basha C. Electrochemical treatment of Procion Black 5B using cylindrical flow reactor--a pilot plant study. J Hazard Mater. 2007;139:381-90 pubmed
    ..Probable theory, reaction mechanism and modeling were proposed for the oxidation of dye effluent. The results obtained reveal the feasibilities of application of electrochemical treatment for the degradation of Procion Black 5B...
  67. Wang X, Lu W, Gu Z, Wei Z, Zhou H. Topology-guided design of an anionic bor-network for photocatalytic [Ru(bpy)3](2+) encapsulation. Chem Commun (Camb). 2016;52:1926-9 pubmed publisher
    ..In light of its anionic nature, the inherent cuboctahedral cage and 1D channel make PCN-99 an excellent matrix to encapsulate the photocatalytic [Ru(bpy)3](2+). ..
  68. Miyazaki S, Kojima T, Mayer J, Fukuzumi S. Proton-coupled electron transfer of ruthenium(III)-pterin complexes: a mechanistic insight. J Am Chem Soc. 2009;131:11615-24 pubmed publisher
    ..In particular, a two-point hydrogen bonding between the complex and the substrate involving the 2-amino group of the deprotonated pterin ligand effectively facilitates the HAT reaction from the substrate to the Ru(III)-pterin complex...
  69. Tfouni E, Doro F, Figueiredo L, Pereira J, Metzker G, Franco D. Tailoring NO donors metallopharmaceuticals: ruthenium nitrosyl ammines and aliphatic tetraazamacrocycles. Curr Med Chem. 2010;17:3643-57 pubmed
    ..This tailoring approach is explored here, being heavily supported by the accumulated knowledge on the chemistry and photochemistry of ruthenium complexes, which allows NO donors/scavengers systems to be custom made designed. ..
  70. Mura P, Camalli M, Casini A, Gabbiani C, Messori L. Trans-cis-cis-[RuCl2(DMSO)2(2-amino-5-methyl-thiazole)2], (PMRu52), a novel ruthenium(II) compound acting as a strong inhibitor of cathepsin B. J Inorg Biochem. 2010;104:111-7 pubmed publisher
    ..5 muM. This latter finding is of particular interest as cathepsin B constitutes an attractive "druggable" target for cancer, rheumatoid arthritis and other important diseases...
  71. Matsuo Y, Matsuo K, Nanao T, Marczak R, Gayathri S, Guldi D, et al. A ruthenium bridge in fullerene-ferrocene arrays: synthesis of [Ru(C60Me5)R(CO)2] (R=C6H4Fc, C identical withCFc) and their charge-transfer properties. Chem Asian J. 2008;3:841-8 pubmed publisher
    ..0 ps; tau(CS)=152 ps). Thus, the structural difference between the phenylene and acetylene bridges in 1 and 2, respectively, was found to change the outcome of the photophysical processes...
  72. Wang Y, Han K. Steric hindrance effect of the equatorial ligand on Fe(IV)O and Ru(IV)O complexes: a density functional study. J Biol Inorg Chem. 2010;15:351-9 pubmed publisher
    ..Finally, we calculated the kinetic isotope effect and investigated the relationship between this effect and reaction barriers...
  73. Moreno A, Pregosin P, Veiros L, Albinati A, Rizzato S. PGSE NMR diffusion overhauser studies on [Ru(Cp*)(eta6-arene)][PF6], plus a variety of transition-metal, inorganic, and organic salts: an overview of ion pairing in dichloromethane. Chemistry. 2008;14:5617-29 pubmed publisher
    ..This represents the first attempt, using experimental data, to understand, correlate, and partially explain the various degrees of ion pairing in a widely different collection of salts...
  74. Li Q, Li H, Du G, Xu Z. Electrochemical detection of bisphenol A mediated by [Ru(bpy)(3)](2+) on an ITO electrode. J Hazard Mater. 2010;180:703-9 pubmed publisher
  75. Prasad G, Mahato T, Yadav S, Singh B. Sulphur mustard vapor breakthrough behaviour on reactive carbon systems. J Hazard Mater. 2007;143:150-5 pubmed
    ..3-0.6 mg/l). The values of kinetic saturation capacity were used to predict the service lives/breakthrough times of carbon beds (when used in filtration systems)...
  76. Rose M, Olmstead M, Mascharak P. Photosensitization via dye coordination: a new strategy to synthesize metal nitrosyls that release NO under visible light. J Am Chem Soc. 2007;129:5342-3 pubmed
  77. Choi B, Park H. Controlling size, amount, and crystalline structure of nanoparticles deposited on graphenes for highly efficient energy conversion and storage. ChemSusChem. 2012;5:709-15 pubmed publisher
  78. Braunschweig H, Dörfler R, Hammond K, Kramer T, Mies J, Radacki K, et al. Synthesis and structure of distanna and tristanna ansa half-sandwich complexes of ruthenium and nickel. Inorg Chem. 2012;51:1225-7 pubmed publisher
    ..Both compounds are characterized by multinuclear NMR spectroscopy and single-crystal diffraction...
  79. Kolar S, Barhoumi R, Lupton J, Chapkin R. Docosahexaenoic acid and butyrate synergistically induce colonocyte apoptosis by enhancing mitochondrial Ca2+ accumulation. Cancer Res. 2007;67:5561-8 pubmed
    ..Collectively, these data show that the combination of DHA and butyrate, compared with butyrate alone, further enhances apoptosis by additionally recruiting a Ca2+ -mediated intrinsic mitochondrial pathway...
  80. Timerbaev A, Foteeva L, Rudnev A, Abramski J, Połeć Pawlak K, Hartinger C, et al. Probing the stability of serum protein-ruthenium(III) drug adducts in the presence of extracellular reductants using CE. Electrophoresis. 2007;28:2235-40 pubmed
    ..This work appears the first to present the application of CE to the stability studies of the protein-bound metallodrugs...
  81. Lo C, Ramani V. SiO?-RuO?: a stable electrocatalyst support. ACS Appl Mater Interfaces. 2012;4:6109-16 pubmed publisher
    ..Analysis of fuel cell performance data confirmed that the lower fuel cell performance resulted largely from ohmic and mass transport losses within the unoptimized electrocatalyst layer...
  82. Zaitsev A, Gruber S, Plüss P, Pregosin P, Veiros L, Wörle M. Fast and highly regioselective allylation of indole and pyrrole compounds by allyl alcohols using Ru-sulfonate catalysts. J Am Chem Soc. 2008;130:11604-5 pubmed publisher
    ..The observed regioselectivity is exceptionally high (up to 100% of the branched isomer). Density functional theory calculations explain these results...
  83. Heinrich T, Von Poelhsitz G, Reis R, Castellano E, Neves A, Lanznaster M, et al. A new nitrosyl ruthenium complex: synthesis, chemical characterization, in vitro and in vivo antitumor activities and probable mechanism of action. Eur J Med Chem. 2011;46:3616-22 pubmed publisher
    ..Also, our results suggest that the mechanism of action of [RuCl(2)NO(BPA)] includes binding to DNA, causing fragmentation of this biological molecule, which leads to apoptosis...
  84. Labeeuw O, Roche C, Phansavath P, Genet J. RuCl3/PPh3: an efficient combination for the preparation of chiral 1,3-anti-diols through catalytic hydrogenation. Org Lett. 2007;9:105-8 pubmed
    ..A short screening of ligands pointed out PPh3 as the most effective phosphine, and PCy3 afforded the 1,3-diols with an unexpected moderate syn selectivity...
  85. Ihee H. Visualizing solution-phase reaction dynamics with time-resolved X-ray liquidography. Acc Chem Res. 2009;42:356-66 pubmed publisher
    ..The resolution should improve to 100 fs or better with X-ray free electron lasers. With this higher resolution, real time observation of ultrafast chemical events such as bond-breaking and bond-making will be possible...
  86. Peng Y, Gao Z. Amplified detection of microRNA based on ruthenium oxide nanoparticle-initiated deposition of an insulating film. Anal Chem. 2011;83:820-7 pubmed publisher
    ..This impedance-based biosensor offers an attractive alternative for miRNA expression profiling and may enable the development of a portable multiplexing miRNA profiling system...
  87. Baggaley E, Elliott A, Bruce J. Oxidant-induced inhibition of the plasma membrane Ca2+-ATPase in pancreatic acinar cells: role of the mitochondria. Am J Physiol Cell Physiol. 2008;295:C1247-60 pubmed publisher
    ..Such a phenomenon may be responsible for the Ca(2+) overload response, and for the transition between apoptotic and necrotic cell death thought to be important in many disease states...
  88. Baratta W, Ballico M, Esposito G, Rigo P. Role of the NH2 functionality and solvent in terdentate CNN alkoxide ruthenium complexes for the fast transfer hydrogenation of ketones in 2-propanol. Chemistry. 2008;14:5588-95 pubmed publisher
  89. Holt K, Ziegler C, Caruana D, Zang J, Millán Barrios E, Hu J, et al. Redox properties of undoped 5 nm diamond nanoparticles. Phys Chem Chem Phys. 2008;10:303-10 pubmed publisher
  90. Das S, Sinha S, Britto R, Somasundaram K, Samuelson A. Cytotoxicity of half sandwich ruthenium(II) complexes with strong hydrogen bond acceptor ligands and their mechanism of action. J Inorg Biochem. 2010;104:93-104 pubmed publisher
  91. Seki T, Tanaka S, Kitamura M. Enantioselective synthesis of pyrrolidine-, piperidine-, and azepane-type N-heterocycles with ?-alkenyl substitution: the CpRu-catalyzed dehydrative intramolecular N-allylation approach. Org Lett. 2012;14:608-11 pubmed publisher
    ..The wide range of applicable N-substitutions, including Boc, Cbz, Ac, Bz, acryloyl, crotonoyl, formyl, and Ts, significantly facilitates further manipulation toward natural product synthesis...