potassium cyanide


Summary: A highly poisonous compound that is an inhibitor of many metabolic processes, but has been shown to be an especially potent inhibitor of heme enzymes and hemeproteins. It is used in many industrial processes.

Top Publications

  1. de Sousa A, Maiorka P, Gonçalves I, Marques de Sá L, Górniak S. Evaluation of effects of prenatal exposure to the cyanide and thiocyanate in wistar rats. Reprod Toxicol. 2007;23:568-77 pubmed
    A study was performed at term and at weaning to verify the toxic effects of the prenatal exposure to potassium cyanide (KCN) and potassium thiocyanate (KSCN) in pregnant Wistar rats...
  2. Barros R, Bonagamba L, Okamoto Canesin R, de Oliveira M, Branco L, Machado B. Cardiovascular responses to chemoreflex activation with potassium cyanide or hypoxic hypoxia in awake rats. Auton Neurosci. 2002;97:110-5 pubmed
    Although intravenous (iv) injection of potassium cyanide (KCN) activates the arterial chemoreflex, it has been questioned whether cytotoxic hypoxia reproduces a physiological stimulus such as hypoxic hypoxia (low inspired O2 tension)...
  3. Yamamoto H, Mohanan P. Melatonin attenuates brain mitochondria DNA damage induced by potassium cyanide in vivo and in vitro. Toxicology. 2002;179:29-36 pubmed
    The effect of potassium cyanide on mitochondria DNA (mtDNA) in mouse brain was investigated in vivo and in vitro. When potassium cyanide (0, 0.1, 1.0 or 2...
  4. Sousa A, Manzano H, Soto Blanco B, Gorniak S. Toxicokinetics of cyanide in rats, pigs and goats after oral dosing with potassium cyanide. Arch Toxicol. 2003;77:330-4 pubmed
  5. Suwanborirux K, Amnuoypol S, Plubrukarn A, Pummangura S, Kubo A, Tanaka C, et al. Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide. J Nat Prod. 2003;66:1441-6 pubmed
    Renieramycins M (1m) and N (1n) were isolated from the Thai sponge Xestospongia sp., pretreated with potassium cyanide in methanolic buffer solution, and their structures and relative stereochemistries were elucidated on the basis of ..
  6. Ha S, Korbas M, Klepsch M, Meyer Klaucke W, Meyer O, Svetlitchnyi V. Interaction of potassium cyanide with the [Ni-4Fe-5S] active site cluster of CO dehydrogenase from Carboxydothermus hydrogenoformans. J Biol Chem. 2007;282:10639-46 pubmed
    ..To understand how CO interacts with the active site, we have studied the reactivity of the cluster with potassium cyanide and analyzed the resulting type of nickel coordination by x-ray absorption spectroscopy...
  7. Fortin J, Waroux S, Giocanti J, Capellier G, Ruttimann M, Kowalski J. Hydroxocobalamin for poisoning caused by ingestion of potassium cyanide: a case study. J Emerg Med. 2010;39:320-4 pubmed publisher
    ..The case supports the efficacy of hydroxocobalamin for acute cyanide poisoning caused by ingestion of a cyanide salt. No adverse events attributed to hydroxocobalamin were observed...
  8. Mironov S, Richter D. Cytoskeleton mediates inhibition of the fast Na+ current in respiratory brainstem neurons during hypoxia. Eur J Neurosci. 1999;11:1831-4 pubmed
  9. Cheng A, Morrison S, Yang D, Hagen S. Energy dependence of restitution in the gastric mucosa. Am J Physiol Cell Physiol. 2001;281:C430-8 pubmed
    ..Our results demonstrate that the glycolytic pathway is essential for restitution after injury in the bullfrog gastric mucosa and that all but complete repair of barrier function occurs in the absence of mitochondrial respiration. ..

More Information

Publications109 found, 100 shown here

  1. Medentsev A, Arinbasarova A, Golovchenko N, Akimenko V. Involvement of the alternative oxidase in respiration of Yarrowia lipolytica mitochondria is controlled by the activity of the cytochrome pathway. FEMS Yeast Res. 2002;2:519-24 pubmed
    ..These data indicate that the alternative system is unable to compete with the cytochrome respiratory chain for electrons. The alternative oxidase only transfers the electrons that are superfluous for the cytochrome respiratory chain. ..
  2. Abdala A, Schoorlemmer G, Colombari E. Ablation of NK1 receptor bearing neurons in the nucleus of the solitary tract blunts cardiovascular reflexes in awake rats. Brain Res. 2006;1119:165-73 pubmed
    ..Thus, these responses depend critically on NK(1)-receptor bearing neurons in the NTS. ..
  3. Nůsková H, Vrbacky M, Drahota Z, Houstek J. Cyanide inhibition and pyruvate-induced recovery of cytochrome c oxidase. J Bioenerg Biomembr. 2010;42:395-403 pubmed publisher
    ..Importantly, we also showed that the COX affinity for oxygen is the most sensitive indicator of cyanide toxic effects. ..
  4. Nagel O, Waldron S, Jones H. An off-line implementation of the stable isotope technique for measurements of alternative respiratory pathway activities. Plant Physiol. 2001;127:1279-86 pubmed
    ..Our method provides results similar to those obtained with laboratory incubations on-line to a mass spectrometer but greatly increases the potential for adoption of the stable isotope method. ..
  5. Nakamura E, Yokoi T, Fukuta H, Iida T, Tanaka Y, Yamamoto Y, et al. Hypoxia differentially modulates the activity of pacemaker and smooth muscle cells in the guinea pig stomach antrum. J Smooth Muscle Res. 2009;45:149-66 pubmed
    ..was prevented by cyclopiazonic acid (CPA) but not by carbonyl cyanide m-chlorophenyl-hydrazone (CCCP), potassium cyanide (KCN) or low-Ca solution...
  6. Nishi H, Inagi R, Kawada N, Yoshizato K, Mimura I, Fujita T, et al. Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions. Am J Pathol. 2011;178:128-39 pubmed publisher
    ..These findings show for the first time, to our knowledge, that Cygb serves as a defensive mechanism against oxidative stress both in vitro and in vivo. ..
  7. Raj R, Puranam R, Kurup C, Ramasarma T. Oxidative activities in mitochondria-like particles from Setaria digitata, a filarial parasite. Biochem J. 1988;256:559-64 pubmed
  8. Lash L, Putt D, Zalups R. Influence of compensatory renal growth on susceptibility of primary cultures of renal cells to chemically induced injury. Toxicol Sci. 2006;94:417-27 pubmed
    ..This is the first report validating the use of a mammalian renal cell culture model to study the toxicological effects of compensatory renal cellular hypertrophy. ..
  9. McLamore E, Zhang W, Porterfield D, Banks M. Membrane-aerated biofilm proton and oxygen flux during chemical toxin exposure. Environ Sci Technol. 2010;44:7050-7 pubmed publisher
    ..during exposure to toxins with known mode of action (chlorocarbonyl cyanide phenyl-hydrazone and potassium cyanide), and four environmental toxins (rotenone, 2,4-dinitrophenol, cadmium chloride, and pentachlorophenol)...
  10. Rumlova L, Dolezalova J. A new biological test utilising the yeast Saccharomyces cerevisiae for the rapid detection of toxic substances in water. Environ Toxicol Pharmacol. 2012;33:459-64 pubmed publisher
    This study evaluates the toxic effects of five substances (atropine, fenitrothion, potassium cyanide, mercuric chloride and lead nitrate) on the yeast Saccharomyces cerevisiae...
  11. Jiang J, Chan A, ALI S, Saha A, Haushalter K, Lam W, et al. Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote. Sci Rep. 2016;6:20831 pubmed publisher
    ..We conclude that sulfide produces a high degree of oxidative stress in cells and tissues, and that cobinamide has promise as a first specific treatment for sulfide poisoning. ..
  12. Papadopoulos M, Binder D, Verkman A. Enhanced macromolecular diffusion in brain extracellular space in mouse models of vasogenic edema measured by cortical surface photobleaching. FASEB J. 2005;19:425-7 pubmed
    ..Our data provide in vivo evidence for enhanced ECS diffusion in vasogenic brain edema, yet greatly slowed diffusion in cytotoxic edema and in and around tumors. ..
  13. Zhang Y, Xi D, Wang J, Zhu D, Guo X. Functional analysis reveals effects of tobacco alternative oxidase gene (NtAOX1a) on regulation of defence responses against abiotic and biotic stresses. Biosci Rep. 2009;29:375-83 pubmed publisher
    ..These results demonstrate that NtAOX1a is necessary for plants to survive low temperature, pathogen attack and oxidative stress by scavenging ROS under these adverse conditions when the CP is restricted. ..
  14. Liu Y, Villamena F, Sun J, Wang T, Zweier J. Esterified trityl radicals as intracellular oxygen probes. Free Radic Biol Med. 2009;46:876-83 pubmed publisher
    ..This study demonstrates that these esterified trityl radicals can function as effective EPR oximetry probes measuring intracellular O2 concentration and consumption. ..
  15. Vu B, Nothnagel H, Vuletich D, Falzone C, Lecomte J. Cyanide binding to hexacoordinate cyanobacterial hemoglobins: hydrogen-bonding network and heme pocket rearrangement in ferric H117A Synechocystis hemoglobin. Biochemistry. 2004;43:12622-33 pubmed
  16. Wang Z, He Z, Shen Q, Gu Y, Li S, Yuan Q. Purification and partial characterization of recombinant Cu, Zn containing superoxide dismutase of Cordyceps militaris in E.coli. J Chromatogr B Analyt Technol Biomed Life Sci. 2005;826:114-21 pubmed
    ..The properties: N-terminal amino acid sequence (the first 12 amino acid residues), pI, subunit molecular mass, thermo-stability of the purified recombinant SOD are similar to that of the native Cu, Zn-SOD from C. militaris (N-cm-SOD). ..
  17. Torgonskaia M, Firsova I, Doronina N, Trotsenko I. [Adaptation of aerobic methylobacteria to dichloromethane degradation]. Prikl Biokhim Mikrobiol. 2007;43:53-8 pubmed
    ..Sodium azide (1 mM) and potassium cyanide (1 mM) inhibited consumption of DCM by these degraders but not by transconjugants Methylobacterium ..
  18. Sahebalzamani H, Ghammamy S, Mehrani K, Jahandide S, Salimi F. Density functional theory studies of structural properties, energies and natural band orbital for two new aluminate compounds. Spectrochim Acta A Mol Biomol Spectrosc. 2012;90:218-22 pubmed publisher
    ..The geometries and normal modes of vibrations obtained from B3LYP calculations are in good agreement with the experimentally observed data. ..
  19. Wallrodt I, Jelsbak L, Thorndahl L, Thomsen L, Lemire S, Olsen J. The putative thiosulfate sulfurtransferases PspE and GlpE contribute to virulence of Salmonella Typhimurium in the mouse model of systemic disease. PLoS ONE. 2013;8:e70829 pubmed publisher
    ..The two genes did not contribute to nitric oxid stress, to synthesis of essential sulfur containing amino acids, nor to detoxification of cyanide. Currently, the precise mechanism by which they contribute to virulence remains elusive. ..
  20. Keith K, Valvano M. Characterization of SodC, a periplasmic superoxide dismutase from Burkholderia cenocepacia. Infect Immun. 2007;75:2451-60 pubmed
    ..Together, these observations establish that B. cenocepacia produces a periplasmic Cu,ZnSOD that protects this bacterium from exogenously generated O2- and contributes to intracellular survival of this bacterium in macrophages. ..
  21. Ozolu R, Okolie N, Ebeigbe A, Karikari N. Effects of sub-chronic oral cyanide on endothelial function in rabbit aortic rings. Hum Exp Toxicol. 2007;26:105-10 pubmed
    ..There were no significant changes in the studied toxicological indices. We conclude that endothelial compromise is necessary for low-dose sub-chronic cyanide-induced to alter vascular reactivity to NA and ACh. ..
  22. Yu X, Lu P, Yu Z. On the role of ?-cyanoalanine synthase (CAS) in metabolism of free cyanide and ferri-cyanide by rice seedlings. Ecotoxicology. 2012;21:548-56 pubmed publisher
  23. Breen P, Isserles S, Tabac E, Roizen M, Taitelman U. Protective effect of stroma-free methemoglobin during cyanide poisoning in dogs. Anesthesiology. 1996;85:558-64 pubmed
    ..Finally, the SFmetHb group and the control group (n = 5, no SFmetHb) received an intravenous potassium cyanide infusion (0.072 mg.kg-1.min-1) for 20 min...
  24. Li L, Prabhakaran K, Shou Y, Borowitz J, Isom G. Oxidative stress and cyclooxygenase-2 induction mediate cyanide-induced apoptosis of cortical cells. Toxicol Appl Pharmacol. 2002;185:55-63 pubmed
    ..These data show that cyanide treatment of cortical cells involves increased COX-2 expression, PGE(2) accumulation, and ROS generation, resulting in apoptotic cell death. ..
  25. Souza V, Escobar M, Bucio L, Hernandez E, Gómez Quiroz L, Gutiérrez Ruiz M. NADPH oxidase and ERK1/2 are involved in cadmium induced-STAT3 activation in HepG2 cells. Toxicol Lett. 2009;187:180-6 pubmed publisher
    ..MAPK promotes STAT3 phosphorylation that could induce a protective mechanism against Cd toxicity. ..
  26. Kim H, Ko K, Lee J, Lee J, Kim J. KCN sensor: unique chromogenic and 'turn-on' fluorescent chemodosimeter: rapid response and high selectivity. Chem Commun (Camb). 2011;47:2886-8 pubmed publisher
    ..DFT/TDDFT calculations support that the fluorescence enhancement of 1-KCN is mainly due to blocking of the ICT process. ..
  27. Park Y, Devlin T, Jones D. Protective effect of the dimer of 16,16-diMePGB1 against KCN-induced mitochondrial failure in hepatocytes. Am J Physiol. 1992;263:C405-11 pubmed
    ..These results demonstrate that dicalciphor protects against KCN-induced damage and that this protection is associated with regulation of specific mitochondrial ion transport functions. ..
  28. van Workum M, van Dooren S, Oldenburg N, Molenaar D, Jensen P, Snoep J, et al. DNA supercoiling depends on the phosphorylation potential in Escherichia coli. Mol Microbiol. 1996;20:351-60 pubmed
    ..ratio was reduced by a shift to anaerobic conditions, by addition of a protonophore (dinitrophenol) or by potassium cyanide addition, DNA supercoiling decreased similarly with the ATP/ADP ratio...
  29. Baxter J, Cummings S. The impact of bioaugmentation on metal cyanide degradation and soil bacteria community structure. Biodegradation. 2006;17:207-17 pubmed
  30. Jones D. Mitochondrial dysfunction during anoxia and acute cell injury. Biochim Biophys Acta. 1995;1271:29-33 pubmed
  31. Knorre D, Dedukhova V, Vyssokikh M, Mokhova E. Cyclosporin A-sensitive cytochrome c release and activation of external pathway of NADH oxidation in liver mitochondria due to pore opening by acidification of phosphate-containing incubation medium. Biosci Rep. 2003;23:67-75 pubmed
  32. Sjöstrand N. [For and against potassium cyanide in "Doctor Glas"]. Lakartidningen. 2003;100:3792 pubmed
  33. Fukui H, Moraes C. Extended polyglutamine repeats trigger a feedback loop involving the mitochondrial complex III, the proteasome and huntingtin aggregates. Hum Mol Genet. 2007;16:783-97 pubmed
    ..Our results suggest that therapeutic interventions targeting complex III and/or proteasome could ameliorate the progress of HD. ..
  34. Downs C, Fauth J, Downs V, Ostrander G. In vitro cell-toxicity screening as an alternative animal model for coral toxicology: effects of heat stress, sulfide, rotenone, cyanide, and cuprous oxide on cell viability and mitochondrial function. Ecotoxicology. 2010;19:171-84 pubmed publisher
    ..Significant differences were observed between controls and treatments and the efficacy of this method was validated; only 2 cm(2) of tissue was required for a seven-point concentration-exposure series. ..
  35. Granjeiro E, Gomes F, Alves F, Crestani C, Correa F, Resstel L. Bed nucleus of the stria terminalis and the cardiovascular responses to chemoreflex activation. Auton Neurosci. 2012;167:21-6 pubmed publisher
    ..These findings suggesting that BNST neurotransmission have not influence on both sympathoexcitatory and parasympathoexcitatory components of the peripheral chemoreflex activation. ..
  36. Chen C, Wang W, Wang X, Dong L, Yue Y, Xin H, et al. Anti-hypoxic activity of the ethanol extract from Portulaca oleracea in mice. J Ethnopharmacol. 2009;124:246-50 pubmed publisher
  37. Nakamura K, Ikeda S, Matsuo T, Hirata A, Takehara M, Hiyama T, et al. Patch clamp analysis of the respiratory chain in Bacillus subtilis. Biochim Biophys Acta. 2011;1808:1103-7 pubmed publisher
    ..subtilis. This is the first step for more detailed analyses of respiratory chain in B. subtilis, especially H(+) translocation mechanism. ..
  38. Liu X, Lu Y, Guan X, Dong B, Chavan H, Wang J, et al. Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism. Biochem Pharmacol. 2015;97:111-21 pubmed publisher
    ..The aldehyde and iminium pathways were further confirmed by using methoxylamine and potassium cyanide as trapping reagents...
  39. Guellil A, Boualam M, Quiquampoix H, Ginestet P, Audic J, Block J. Hydrolysis of wastewater colloidal organic matter by extracellular enzymes extracted from activated sludge flocs. Water Sci Technol. 2001;43:33-40 pubmed
    ..The protein hydrolysis mainly resulted from the enzymatic activity of EPS, whereas the glycolytic activity was mainly present in the organic colloidal fraction of the wastewater. ..
  40. Psylinakis E, Davoras E, Ioannidis N, Trikeriotis M, Petrouleas V, Ghanotakis D. Isolation and spectroscopic characterization of a recombinant bell pepper hydroperoxide lyase. Biochim Biophys Acta. 2001;1533:119-27 pubmed
    ..The striking similarities between both the ferric and ferrous HPO lyase-NO complexes with the analogous P450 complexes, suggest that the active sites of HPO lyase and P450 share common structural features. ..
  41. Imosemi I, Malomo A, Oladejo O, Osuagwu F, Ekpo O, Akang E, et al. Gross morphological studies on the effect of cyanide on the developing cerebellum of wistar rat (rattus novegicus). Afr J Med Med Sci. 2005;34:59-63 pubmed
    ..The control animals were fed a standard diet of mice cubes, while the experimental animals were fed 500 ppm potassium cyanide, mixed with the standard diet...
  42. Bakeeva L, Dzyubinskaya E, Samuilov V. Programmed cell death in plants: ultrastructural changes in pea guard cells. Biochemistry (Mosc). 2005;70:972-9 pubmed
    ..An antioxidant di-tert-butyl-4-hydroxytoluene prevented ultrastructural changes in the cells observed after 6 h of incubation with CN-. Thus, the CN--induced death of the guard cells of stomata occurs through the mechanism of apoptosis. ..
  43. Hariharakrishnan J, Satpute R, Prasad G, Bhattacharya R. Oxidative stress mediated cytotoxicity of cyanide in LLC-MK2 cells and its attenuation by alpha-ketoglutarate and N-acetyl cysteine. Toxicol Lett. 2009;185:132-41 pubmed publisher
    ..Cells were treated with various concentrations of potassium cyanide (KCN) for different time intervals and cytotoxicity was evidenced by increased leakage of intracellular ..
  44. Bolaji O, Olabode O. Modulating effect of aqueous extract of Telfairia occidentalis on induced cyanide toxicity in rats. Niger J Physiol Sci. 2011;26:185-91 pubmed
    ..However, further bioassay guided fractionation and analytical studies are needed to identify the actual chemical compound or molecule in the vegetable responsible for or associated with the observed effects. ..
  45. Eskandarzade N, Aminlari M, Golami S, Tavana M. Rhodanese activity in different tissues of the ostrich. Br Poult Sci. 2012;53:270-3 pubmed publisher
    ..5. The results suggest that the main organs harbouring high rhodanese activity in the ostrich are associated with sites likely to be required in rhodanese mediated cyanide detoxification. ..
  46. Hama H, Shimamoto T, Tsuda M, Tsuchiya T. Characterization of a novel L-serine transport system in Escherichia coli. J Bacteriol. 1988;170:2236-9 pubmed
    ..Uptake of H+ was induced by L-serine influx. These results indicate that an H+-serine cotransport mechanism is operative in this novel L-serine transport system...
  47. Maier R, Prosser J. Hydrogen-mediated mannose uptake in Azotobacter vinelandii. J Bacteriol. 1988;170:1986-9 pubmed
    ..Respiratory inhibitors, such as potassium cyanide, hydroxylamine, and p-chloromercuribenzoic acid, as well as the proton conductor carbonyl cyanide m-..
  48. Nishimura Y, Lemasters J. Glycine blocks opening of a death channel in cultured hepatic sinusoidal endothelial cells during chemical hypoxia. Cell Death Differ. 2001;8:850-8 pubmed
    ..5 mM potassium cyanide (chemical hypoxia)...
  49. Hayward L. Evidence for alpha-2 adrenoreceptor modulation of arterial chemoreflexes in the caudal solitary nucleus of the rat. Am J Physiol Regul Integr Comp Physiol. 2001;281:R1464-73 pubmed
    ..Arterial chemoreflex responses to intravenous injections of potassium cyanide (KCN; 75 microg/kg) were recorded before and following blockade of alpha-2 adrenoreceptors in the cNTS of ..
  50. Haddad N, Yuan Q. Purification and some properties of Cu,Zn superoxide dismutase from Radix lethospermi seed, kind of Chinese traditional medicine. J Chromatogr B Analyt Technol Biomed Life Sci. 2005;818:123-31 pubmed
    ..Finally, in the presence of 2 mM ethylendiamine tetra acetic acid (EDTA) and sodium dodecyl sulphate (SDS), the enzyme showed approximately 18 and 34% activity loss...
  51. Soto Blanco B, Stegelmeier B, Gorniak S. Clinical and pathological effects of short-term cyanide repeated dosing to goats. J Appl Toxicol. 2005;25:445-50 pubmed
    ..Significant histologic lesions in goats were observed and need to be characterized further...
  52. Burillo Putze G, Nogué Xarau S, Duenas Laita A. Another antidote to acute cyanide poisoning. Pediatr Crit Care Med. 2006;7:611; author reply 611 pubmed
  53. Ramadan Z, Wrang M, Tipton K. Species differences in the selective inhibition of monoamine oxidase (1-methyl-2-phenylethyl)hydrazine and its potentiation by cyanide. Neurochem Res. 2007;32:1783-90 pubmed
    ..The kinetic behaviour of cyanide activation was consistent with partial (non-essential) competitive activation in all cases...
  54. Ghamsari L, Keyhani E, Golkhoo S. Kinetics properties of guaiacol peroxidase activity in Crocus sativus L. corm during rooting. Iran Biomed J. 2007;11:137-146 pubmed
    ..Guaiacol peroxidases (GP) are haem-containing enzymes participating in many physiological processes in plants. The expression pattern of these enzymes is organ-specific and developmentally regulated...
  55. Panfoli I, Calzia D, Bianchini P, Ravera S, Diaspro A, Candiano G, et al. Evidence for aerobic metabolism in retinal rod outer segment disks. Int J Biochem Cell Biol. 2009;41:2555-65 pubmed publisher
    ..These findings may provide important new insight into energy production in outer segments via aerobic metabolism and additional information about protein components in OS disk membranes...
  56. Villani G, Greco M, Papa S, Attardi G. Low reserve of cytochrome c oxidase capacity in vivo in the respiratory chain of a variety of human cell types. J Biol Chem. 1998;273:31829-36 pubmed
    ..This conclusion has important implications for understanding the role of physiological or pathological factors in affecting the COX threshold...
  57. Glatz Z, Bouchal P, Janiczek O, Mandl M, Ceskova P. Determination of rhodanese enzyme activity by capillary zone electrophoresis. J Chromatogr A. 1999;838:139-48 pubmed
    ..The developed capillary electrophoretic method also has great potential for thiocyanate determinations in other applications...
  58. Ivanov B. The competition between methyl viologen and monodehydroascorbate radical as electron acceptors in spinach thylakoids and intact chloroplasts. Free Radic Res. 2000;33:217-27 pubmed
    ..The competition between methyl viologen and monodehydroascorbate radical in the intact chloroplasts was estimated under various conditions...
  59. Borghouts C, Werner A, Elthon T, Osiewacz H. Copper-modulated gene expression and senescence in the filamentous fungus Podospora anserina. Mol Cell Biol. 2001;21:390-9 pubmed
    ..However, it is striking that the permeability of mitochondrial membranes in animal systems changes during apoptosis and that mitochondrial proteins with an important impact on this type of cellular death are released...
  60. Safar M, Duriez M, Corman B, Levy B. Endothelium-dependent changes in arterial diameter in old normotensive rats. Clin Exp Pharmacol Physiol. 2001;28:371-5 pubmed
    ..conditions, after removal of the endothelium and after total relaxation of vascular smooth muscle by potassium cyanide. Histomorphometry of the carotid wall was studied after pressure fixation (100 mmHg) of the arteries. 3...
  61. Tan H, Heywood D, Ralph G, Bienemann A, Baker A, Uney J. Tissue inhibitor of metalloproteinase 1 inhibits excitotoxic cell death in neurons. Mol Cell Neurosci. 2003;22:98-106 pubmed
    ..These findings have a fundamental implication for our understanding of the physiological role of secreted TIMP-1 in the central nervous system...
  62. Nair K, Hanson S, Mendez A, Gurevich E, Kennedy M, Shestopalov V, et al. Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions. Neuron. 2005;46:555-67 pubmed
    ..These results indicate that the distribution of arrestin in rods is controlled by its dynamic interactions with rhodopsin in the OS and microtubules in the IS and that its movement occurs by simple diffusion...
  63. Lüke M, Weiergräber M, Brand C, Siapich S, Banat M, Hescheler J, et al. The isolated perfused bovine retina--a sensitive tool for pharmacological research on retinal function. Brain Res Brain Res Protoc. 2005;16:27-36 pubmed
    ..The recording of the ERG from the isolated and perfused bovine retina serves as a valuable physiological model for a neuronal network in which important questions related to the retinal signalling and metabolism can be investigated...
  64. Huang Y, Hamaguchi H. [Time- and space resolved Raman spectroscopy of single living yeast cells]. Tanpakushitsu Kakusan Koso. 2006;51:262-7 pubmed
  65. Ungvari Z, Labinskyy N, Gupte S, Chander P, Edwards J, Csiszar A. Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats. Am J Physiol Heart Circ Physiol. 2008;294:H2121-8 pubmed publisher
    ..We posit that impaired mitochondrial biogenesis and downregulation of COX may contribute to the increased mitochondrial oxidative stress in aged endothelial cells...
  66. Song N, Zheng Y, E S, Li D. Cloning, expression, and characterization of thermostable manganese superoxide dismutase from Thermoascus aurantiacus var. levisporus. J Microbiol. 2009;47:123-30 pubmed publisher
    ..The optimum temperature of the enzyme was 55 degrees C and it exhibited maximal activity at pH 7.5. The enzyme was thermostable at 50 and 60 degrees C and the half-life at 80 degrees C was approximately 40 min...
  67. Lu C, Lin Y, Yeh S. Spectroscopic studies of ligand and substrate binding to human indoleamine 2,3-dioxygenase. Biochemistry. 2010;49:5028-34 pubmed publisher
    ..The data support the view that during the active turnover of the enzyme it is kinetically more favored to bind O(2) prior to l-Trp...
  68. Murali M, Raja S, Devaraj S. Neutralization of radical toxicity by temperature-dependent modulation of extracellular SOD activity in coral bleaching pathogen Vibrio shiloi and its role as a virulence factor. Arch Microbiol. 2010;192:619-23 pubmed publisher
    ..Since, increased activity of novel Mn-SOD at higher temperature, leads to the neutralization of radical toxicity and facilitates the survival of V. shiloi. Hence, the extracellular Mn-SOD may be considered as a virulence factor...
  69. Kung L, Scrogin K. Serotonin nerve terminals in the dorsomedial medulla facilitate sympathetic and ventilatory responses to hemorrhage and peripheral chemoreflex activation. Am J Physiol Regul Integr Comp Physiol. 2011;301:R1367-79 pubmed publisher
    ..Both ventilatory and sympathetic responses to chemoreceptor activation with potassium cyanide injection were attenuated by the lesion...
  70. Motie M, Kassner R, Meyer T, Cusanovich M. Kinetics of cyanide binding to Chromatium vinosum ferricytochrome c'. Biochemistry. 1990;29:1932-6 pubmed
    ..abstract truncated at 250 words)..
  71. Menon S, Ragsdale S. Unleashing hydrogenase activity in carbon monoxide dehydrogenase/acetyl-CoA synthase and pyruvate:ferredoxin oxidoreductase. Biochemistry. 1996;35:15814-21 pubmed
    ..Several physiological roles for proton reduction by CODH/ACS and PFOR are discussed, including the prevention of radical formation from reduced metal clusters when electron carriers (ferredoxin, flavodoxin, etc.) are limiting...
  72. Dreykluft T, Göbel U, Taveira O, Nürnberg M, Luft F, Kettritz R. Blue acid blues. Nephrol Dial Transplant. 2004;19:2668-71 pubmed
  73. Machado B, Bonagamba L. Antagonism of glutamate receptors in the intermediate and caudal NTS of awake rats produced no changes in the hypertensive response to chemoreflex activation. Auton Neurosci. 2005;117:25-32 pubmed
    ..We suggest that neurotransmitter other than l-glutamate may take part in the neurotransmission of the sympathoexcitatory component of the chemoreflex at the NTS level...
  74. Mubarakshina M, Khorobrykh S, Ivanov B. Oxygen reduction in chloroplast thylakoids results in production of hydrogen peroxide inside the membrane. Biochim Biophys Acta. 2006;1757:1496-503 pubmed
    ..Neither the presence of a superoxide dismutase inhibitor, potassium cyanide or sodium azide, in the thylakoid suspension, nor unstacking of the thylakoids appreciably affected the ..
  75. Kito Y, Suzuki H. Effects of temperature on pacemaker potentials in the mouse small intestine. Pflugers Arch. 2007;454:263-75 pubmed
    ..The results also suggest that the mitochondria-induced intracellular Ca(2+) handling system seems to be involved in the initiation of the generation of pacemaker potentials but not in their configuration...
  76. Mestres P, Morguet A, Schmidt W, Kob A, Thedinga E. A new method to assess drug sensitivity on breast tumor acute slices preparation. Ann N Y Acad Sci. 2006;1091:460-9 pubmed
    ..Metabolic activity was inhibited by sodium fluoride, which reduces glycolysis, and potassium cyanide, which inhibits respiration...
  77. Vasil ev L, Vorobyov A, Dzyubinskaya E, Nesov A, Shestak A, Samuilov V. Cyanide-induced death of cells in plant leaves. Biochemistry (Mosc). 2007;72:572-82 pubmed
  78. Guo F, Shi Jin E, Liu S, Chen J, Li D. Purification and characterization of a thermostable MnSOD from the thermophilic fungus Chaetomium thermophilum. Mycologia. 2008;100:375-80 pubmed
    ..5 and optimum temperature at 60 C. It was thermostable at 50 and 60 C and retained 60% activity after 60 min at 70 C. The half-life of the SOD at 80 C was approximately 25 min and even retained 20% activity after 30 min at 90 C...
  79. Tarasenko V, Garnik E, Shmakov V, Konstantinov Y. Induction of Arabidopsis gdh2 gene expression during changes in redox state of the mitochondrial respiratory chain. Biochemistry (Mosc). 2009;74:47-53 pubmed
    ..Inhibition of complex I by rotenone did not influence the transcript level, but treatment with potassium cyanide, a complex IV inhibitor, also increased the transcript content...
  80. Abdel Zaher A, Abdel Hady R, Abdel Moneim W, Salim S. Alpha-lipoic acid protects against potassium cyanide-induced seizures and mortality. Exp Toxicol Pathol. 2011;63:161-5 pubmed publisher
    This study was proposed to investigate the potential protective effect of alpha-lipoic acid (?-LA) against potassium cyanide (KCN)-induced seizures and lethality in mice...
  81. Mercier G, Palanisami A, Miller J. Nonlinear dielectric spectroscopy for label-free detection of respiratory activity in whole cells. Biosens Bioelectron. 2010;25:2107-14 pubmed publisher
    ..e. mutant yeast strains or yeast in the presence of respiratory inhibitors. The method holds potential for further development to detect respiratory activity in live tissue in vitro and perhaps in vivo for clinical applications...
  82. Sajitha Rajan S, Murugan K. Purification and kinetic characterization of the liverwort Pallavicinia lyelli (Hook.) S. Gray. cytosolic ascorbate peroxidase. Plant Physiol Biochem. 2010;48:758-63 pubmed publisher
    ..The data obtained in this study may help to understand desiccation tolerance mechanism in the liverwort...
  83. Nunes F, Ribeiro T, França Silva M, Medeiros I, Braga V. Superoxide scavenging in the rostral ventrolateral medulla blunts the pressor response to peripheral chemoreflex activation. Brain Res. 2010;1351:141-9 pubmed publisher
    ..Peripheral chemoreflex activation with potassium cyanide (80 microg/kg, i.v...
  84. Killick D, Bushby N. A modern approach to the synthesis of 2-(4-chlorophenyl)[2-(14)C]thiazol-4-ylacetic acid ([(14)C] fenclozic acid) and its acyl glucuronide metabolite. J Labelled Comp Radiopharm. 2013;56:17-21 pubmed publisher
    An updated approach to the 1960s synthesis of [(14)C] fenclozic acid from labelled potassium cyanide is presented...
  85. Yamagiwa T, Inokuchi S, Saito T, Inoue S, Morita S, Kawaguchi A. A stable in vitro method for assessing the toxicity of potassium cyanide and its antidote. Tokai J Exp Clin Med. 2013;38:114-22 pubmed
    ..Hydrogen cyanide possesses a high acid-dissociation constant of 9.14, favoring its vaporization and depletion from the culture media at physiological pH, which may cause the cyanide toxicity unstable in vitro...
  86. Myers K, Fiskum G, Liu Y, Simmens S, Bredesen D, Murphy A. Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability. J Neurochem. 1995;65:2432-40 pubmed
    ..the survival of control and bcl-2 transfectants of a hypothalamic tumor cell line, GT1-7, exposed to potassium cyanide in the absence of glucose (chemical hypoxia/aglycemia)...
  87. Talbot P, DiCarlantonio G, Knoll M, Gomez C. Identification of cigarette smoke components that alter functioning of hamster (Mesocricetus auratus) oviducts in vitro. Biol Reprod. 1998;58:1047-53 pubmed
    ..All test components (acrolein, formaldehyde, phenol, acetaldehyde, and potassium cyanide [KCN]) inhibited ciliary beat frequency in a dose-dependent manner...
  88. Zal F, Leize E, Lallier F, Toulmond A, Van Dorsselaer A, Childress J. S-Sulfohemoglobin and disulfide exchange: the mechanisms of sulfide binding by Riftia pachyptila hemoglobins. Proc Natl Acad Sci U S A. 1998;95:8997-9002 pubmed
    ..Moreover, we also demonstrate that the larger V1 Hb can form persulfide groups on its linker chains, a mechanism that can account for the higher sulfide-binding potential of this Hb...
  89. Huang H, Weng C, Ou S, Hwang T. Selective subcellular redistributions of protein kinase C isoforms by chemical hypoxia. J Neurosci Res. 1999;56:668-78 pubmed
    ..Taking the results together, differential activation/translocation of PKC isozymes by KCN and TPA is important in the regulation of chemical hypoxia-induced cell injury in PC12 cells...
  90. Ogawa K, Iwabuchi M. A mechanism for promoting the germination of Zinnia elegans seeds by hydrogen peroxide. Plant Cell Physiol. 2001;42:286-91 pubmed
  91. Breen C, Sykes D, Fricker G, Miller D. Confocal imaging of organic anion transport in intact rat choroid plexus. Am J Physiol Renal Physiol. 2002;282:F877-85 pubmed
  92. Rachinger J, Fellner F, Stieglbauer K, Trenkler J. MR changes after acute cyanide intoxication. AJNR Am J Neuroradiol. 2002;23:1398-401 pubmed
    ..Our case shows pseudolaminar necrosis along the central cerebral cortex 3 weeks after cyanide poisoning, showing that the sensorimotor cortex is also a site for toxic necrosis because of its high oxygen dependency...