technetium tc 99m pyrophosphate


Summary: A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the extremities.

Top Publications

  1. Mochizuki T, Murase K, Higashino H, Miyagawa M, Sugawara Y, Kikuchi T, et al. Ischemic "memory image" in acute myocardial infarction of 123I-BMIPP after reperfusion therapy: a comparison with 99mTc-pyrophosphate and 201Tl dual-isotope SPECT. Ann Nucl Med. 2002;16:563-8 pubmed
    ..001). In conclusion, the ischemic "memory image" obtained by means of the BMIPP is a common phenomenon (13/14) in AMI, and helpful in evaluating the area at risk...
  2. Zen K, Ito K, Hikosaka T, Adachi Y, Yoneyama S, Katoh S, et al. Uncommon and dynamic changes detected by 123I-15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid myocardial single photon emission computed tomography in a stunned myocardium induced by coronary microvascular spasm. Ann Nucl Med. 2000;14:303-9 pubmed
  3. Boswell C, Ferl G, Mundo E, Schweiger M, Marik J, Reich M, et al. Development and evaluation of a novel method for preclinical measurement of tissue vascular volume. Mol Pharm. 2010;7:1848-57 pubmed publisher
    ..In addition, these observations emphasize the importance of obtaining accurate physiological parameter values for modeling antibody uptake. ..
  4. Volpini M, Giubbini R, Gei P, Cuccia C, Franzoni P, Riva S, et al. Diagnosis of acute myocardial infarction by indium-111 antimyosin antibodies and correlation with the traditional techniques for the evaluation of extent and localization. Am J Cardiol. 1989;63:7-13 pubmed
    ..No adverse reactions or side effects were noted after injection of AMA-Fab in any patient. It is concluded that planar myocardial scintigraphy with AMA-Fab is a reliable method for AMI detection and location. ..
  5. Timmons J, Hartshorne M, Peters V, Cawthon M, Bauman J. Muscle necrosis in the extremities: evaluation with Tc-99m pyrophosphate scanning--a retrospective review. Radiology. 1988;167:173-8 pubmed
    ..Special caution is required in those cases in which muscle necrosis is due to acute causes (e.g., traumatic thrombosis) rather than chronic vascular disease. ..
  6. Bisi G, Sciagra R, Santoro G, Brocchi A, Paladini S, Fazzini P. [Use of antimyosin monoclonal antibodies in the diagnosis of acute myocardial infarct. Comparison with other imaging technics and in vivo kinetics study]. G Ital Cardiol. 1988;18:281-9 pubmed
    ..In-vivo kinetics was characterized by a slow clearance from the blood pool.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  7. Çiftçi Ã, Gül S, Açıksarı K, Maman A, ÇavuÅŸoÄŸlu T, Bademci R, et al. The diagnostic utility of scintigraphy in esophageal burn: a rat model. J Surg Res. 2016;200:495-500 pubmed publisher
    ..0005). The scintigraphic imaging may provide advantages in the early stage of esophageal burns in some patients whom endoscopic procedure is contraindicated because of its high risk of complications such as bleeding and perforation. ..
  8. Delpassand E, Dhekne R, Barron B, Moore W. Evaluation of soft tissue injury by Tc-99m bone agent scintigraphy. Clin Nucl Med. 1991;16:309-14 pubmed
    ..The degree and extent of tissue necrosis was precisely identified by scintigraphy. In two of these, radionuclide imaging helped to establish accurately the level of amputation that resulted in appropriate wound healing. ..
  9. Turnbull L, Ridgway J, Nicoll J, Bell D, Best J, Muir A. Estimating the size of myocardial infarction by magnetic resonance imaging. Br Heart J. 1991;66:359-63 pubmed
    ..Magnetic resonance imaging after acute infarction allows measurement of infarct size and this may prove useful in assessing new treatments designed to salvage myocardium. ..

More Information

Publications114 found, 100 shown here

  1. Hole T, Rokkones T. [Myocardial 99mTc-pyrophosphate scintigraphy in acute heart infarct]. Tidsskr Nor Laegeforen. 1990;110:596-7 pubmed
    ..55). We conclude that, in our hospital, 99mTc-pyrophosphate myocardial scintigraphy did not contribute valuable information to the routine diagnosis of myocardial infarction...
  2. Mones J, Carrio I, Roca M, Estorch M, Calabuig R, Sainz S, et al. Gastric emptying of two radiolabelled antacids. Gut. 1991;32:147-50 pubmed
    ..01). When the mean percentages of retention at six time intervals were compared for both antacids, it was found that Maalox emptied much faster (p less than 0.01 at 15 and 30 minutes, p less than 0.02 at 45, 60, 75, and 90 minutes). ..
  3. Aoki T, Nishikawa H, Motoyasu M, Shimizu Y, Fukui A, Ono N, et al. [A case of stunned myocardium with marked 99mTc-PYP accumulation]. Kaku Igaku. 1993;30:61-7 pubmed
    ..g., in cases of acute myocardial infarction). The uptake of 99mTc-PYP into stunned myocardium has not been reported before. Thus, this case is rare and noteworthy. ..
  4. Krause T, Joseph A, Kutzner C, Kasper W, Schuemichen C, Just H, et al. Acute myocardial infarction delineated by noninvasive thallium-201/technetium-99m pyrophosphate tomography. Nucl Med Commun. 1990;11:617-29 pubmed
    ..It is concluded that combined 201Tl/99Tcm PPi tomography is highly accurate for determining the presence and location of acute myocardial infarction. This technique appears to be superior to studies where only one radioisotope is used. ..
  5. Duska F, Hadas L, Vizda J, Kafka P, Urbanova E, Palicka V, et al. 99mTc-aminohexylidendiphosphonate and 99mTc-pyrophosphate in the scintigraphic diagnosis of experimental myocardial infarction in dogs. Nuklearmedizin. 1988;27:226-7 pubmed
    ..The in-vivo scan and the radioactivity of tissue samples demonstrated that 99mTc-AHDP is as suitable for imaging acute myocardial infarction as is the commonly used 99mTc-pyrophosphate. ..
  6. Bjarnason I, Zanelli G, Prouse P, Smethurst P, Smith T, Levi S, et al. Blood and protein loss via small-intestinal inflammation induced by non-steroidal anti-inflammatory drugs. Lancet. 1987;2:711-4 pubmed
    ..These studies show that small intestinal inflammation caused by NSAIDs is associated with blood and protein loss, both of which may contribute to the general ill-health of rheumatic patients...
  7. Nakajima K, Shuke N, Nitta Y, Taki J, Matsubara T, Terashima N, et al. Comparison of 99Tcm-pyrophosphate, 201T1 perfusion, 123I-labelled methyl-branched fatty acid and sympathetic imaging in acute coronary syndrome. Nucl Med Commun. 1995;16:494-503 pubmed
    ..123I-BMIPP and MIBG are more sensitive for the detection of damaged myocardium, and the difference between perfusion and metabolism seems to reflect myocardial stunning. ..
  8. Sochor H, Schwaiger M, Schelbert H, Huang S, Ellison D, Hansen H, et al. Relationship between Tl-201, Tc-99m (Sn) pyrophosphate and F-18 2-deoxyglucose uptake in ischemically injured dog myocardium. Am Heart J. 1987;114:1066-77 pubmed
    ..Our results indicate that a dual tracer approach might best characterize the presence and extent of reversibly and of irreversibly injured tissue in a given myocardial region...
  9. Morita M, Naruse H, Yamamoto J, Itano M, Kawamoto H, Fukutake N, et al. [Diagnostic utility of 111In-antimyosin Fab scintigraphy in acute myocardial infarction: comparison with 201Tl and 99mTc-pyrophosphate myocardial scintigraphy]. Kaku Igaku. 1991;28:1483-90 pubmed
    ..72), In-AM SPECT and Tl SPECT (r = 0.79), In-AM planar and PYP planar (r = 0.92), In-AM SPECT and PYP SPECT (r = 0.76), respectively (p less than 0.01). Thus, In-AM is a useful method for diagnosis of AMI. ..
  10. Suzuki A, Matsushima H, Satoh A, Hayashi H, Sotobata I. Prognostic implications of cardiac scintigraphic parameters obtained in the early phase of acute myocardial infarction. Clin Cardiol. 1988;11:370-6 pubmed
    ..Radionuclide parameters obtained in the early phase of acute myocardial infarction were useful for detecting both patients with grave complications and those with poor late prognosis during a mean follow-up period of 2.6 years. ..
  11. Lin W, Wang S, Hwang D, Lan J, Yeh S. Technetium-99m-pyrophosphate scintigraphic findings of intestinal perforation in dermatomyositis. J Nucl Med. 1995;36:1615-7 pubmed
    ..The abdominal plain radiograph revealed only dilatation of the intestinal loops; increased radioactivity, however, was clearly demonstrated in the early 5-min and delayed 3-hr 99mTc-pyrophosphate images. ..
  12. Haapaniemi T, Nylander G, Sirsjo A, Larsson J. Hyperbaric oxygen reduces ischemia-induced skeletal muscle injury. Plast Reconstr Surg. 1996;97:602-7; discussion 608-9 pubmed
    ..05). After 4 hours of ischemia, the changes in levels of the intracellular muscle compounds adenosine triphosphate, phosphocreatine, and lactate were less in the hyperbaric oxygen-treated rats than in the untreated animals. ..
  13. Gunzburg R, Servais F, Verhas M. Tomoscintigraphy of the lumbar spine: prospects and clinical application. Eur Spine J. 1994;3:308-11 pubmed
    ..Of patients with acute LBP 50% had a normal disc SPECT; it is concluded that in these cases a non-discal origin for the pain must be sought. ..
  14. Ando H, Fukuyama T, Mitsuoka W, Egashira S, Imamura Y, Masaki H, et al. Influence of downscatter in simultaneously acquired thallium-201/technetium-99m-PYP SPECT. J Nucl Med. 1996;37:781-5 pubmed
    ..There in a considerable 99mTc downscatter into the 201Tl window, which prevents precise quantification of MI in simultaneously acquired dual-isotope 201Tl/99mTc-pyrophosphate imaging. ..
  15. Cieslak T, Ottolini M, O Neill K, Lampe R. Staphylococcus aureus meningitis associated with pyogenic infection of the sacroiliac joint. South Med J. 1993;86:1175-8 pubmed
    ..Radionuclide scanning with 99mTc or 67Ga is usually helpful in the early confirmation of this condition, the presence of which may be suspected on the basis of thorough physical examination. ..
  16. Tessier J, Salimi Z, Restrepo G, Samuels L, Joist J. Experimental hemarthrosis in dogs: progressive synovitis monitored with technetium-99m pyrophosphate joint imaging. Haemostasis. 1988;18:83-90 pubmed
    ..Evidence is also presented that the intensity of Tc99m-PYP joint accumulation (immediate static images) may not readily reflect synovial vascularity or synovial tissue mass. ..
  17. Krause T, Zeiher A, Kasper W, Schwehn M, Schümichen C, Moser E. Combined thallium 201/technetium 99m-labeled pyrophosphate tomography for identification of the "culprit" vessel in acute myocardial infarction. J Nucl Cardiol. 1996;3:105-13 pubmed
  18. Yazaki Y, Isobe M, Hayasaka M, Tanaka M, Fujii T, Sekiguchi M. Cardiac sarcoidosis mimicking hypertrophic cardiomyopathy: clinical utility of radionuclide imaging for differential diagnosis. Jpn Circ J. 1998;62:465-8 pubmed
    ..However, hypertrophy in the basal portion of the IVS is an important sign of early cardiac involvement in sarcoidosis. 67Ga and 99mTc-PYP scintigraphy were useful and necessary to differentiate this type of cardiac sarcoidosis from HCM. ..
  19. Bruyant P, Sau J, Mallet J. Noise removal using factor analysis of dynamic structures: application to cardiac gated studies. J Nucl Med. 1999;40:1676-82 pubmed
    ..This tool does not decrease the spatial resolution (compared with smoothing filters) and does not lose details (compared with frequential filters). Once the number of factors is chosen, this method is not operator dependent. ..
  20. Finkelstein D, Noyek A, Kirsh J. Red blood cell scan in cavernous hemangioma of the larynx. Ann Otol Rhinol Laryngol. 1989;98:707-12 pubmed
    ..This report describes our satisfactory diagnostic imaging experience with the radionuclide RBC scan and suggests both its imaging specificity and its role in the management of this lesion. ..
  21. Petit J, Losay J, Leriche H, Piot J, Binet J. [Endoluminal mitral valvuloplasty in young adults and children. Apropos of 10 cases]. Arch Mal Coeur Vaiss. 1987;80:1261-7 pubmed
    ..01). Similarly, the end-systolic gradient evaluated by Doppler, fell from 17.5 +/- 8.9 to 5.3 +/- 4.7 mmHg (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS) ..
  22. Crenshaw A, Friden J, Hargens A, Lang G, Thornell L. Increased technetium uptake is not equivalent to muscle necrosis: scintigraphic, morphological and intramuscular pressure analyses of sore muscles after exercise. Acta Physiol Scand. 1993;148:187-98 pubmed
  23. Umamoto I, Sugihara H, Harada Y, Sawada T, Matsumuro A, Matsubara K, et al. [The clinical significance of reverse redistribution of Tl-201 SPECT at rest in the 1st month after the onset of acute myocardial infarction]. Kaku Igaku. 1991;28:749-57 pubmed
    ..It is concluded that the r-RD pattern at rest in the 1st month after the onset of AMI may be a sign of viable myocardium. ..
  24. Tamaki N, Yamada T, Matsumori A, Yoshida A, Fujita T, Ohtani H, et al. Indium-111-antimyosin antibody imaging for detecting different stages of myocardial infarction: comparison with technetium-99m-pyrophosphate imaging. J Nucl Med. 1990;31:136-42 pubmed
    ..Thus, AM scans can be considered to provide a sensitive diagnosis of subacute as well as acute myocardial necrosis. ..
  25. Anderson R, Cambria R, Kerr J, Hobson R. Sustained benefit of temporary limited reperfusion in skeletal muscle following ischemia. J Surg Res. 1990;49:271-5 pubmed
    ..Results are reported as the mean +/- SEM: [table: see text] These data demonstrate a sustained benefit from temporary limited reperfusion. This methodology should be considered in the surgical management of the acutely ischemic limb. ..
  26. Labbe R, Lindsay T, Gatley R, Romaschin A, Mickle D, Wilson G, et al. Quantitation of postischemic skeletal muscle necrosis: histochemical and radioisotope techniques. J Surg Res. 1988;44:45-53 pubmed
    ..This study demonstrates the ability of tetrazolium staining to accurately differentiate between viable and necrotic skeletal muscle and provides a reproducible method for estimating the extent of necrosis in the gracilis muscle model. ..
  27. Chang H, Kao C, Lian J, Shu K, Cheng C, Wu M, et al. Evaluation of the severity of traumatic rhabdomyolysis using technetium-99m pyrophosphate scintigraphy. Am J Nephrol. 2001;21:208-14 pubmed
    ..706, p < 0.01) was also observed. We concluded that this scoring method may be used as an adjunct for evaluating the locations of trauma and the severity of crush syndrome, and for predicting the duration of hospital stay...
  28. Weismuller P, Henze E, Adam W, Roth J, Bitter F, Stauch M. Parametric imaging of experimentally simulated Wolff-Parkinson-White syndrome conduction abnormalities in dogs: a concise communication. Am J Physiol Imaging. 1986;1:208-13 pubmed
    ..Neither the antero- or posteroseptal nor the right ventricular premature contraction pattern could be exactly localized...
  29. Takahashi N, Inoue T, Oka T, Suzuki A, Kawano T, Uchino K, et al. Diagnostic use of T2-weighted inversion-recovery magnetic resonance imaging in acute coronary syndromes compared with 99mTc-Pyrophosphate, 123I-BMIPP and 201TlCl single photon emission computed tomography. Circ J. 2004;68:1023-9 pubmed
    ..725, 0.731 and 0.878, respectively. The difference between the areas of MRI and BMIPP was significant (p<0.05). Accurate detection of culprit lesion is improved by using MRI rather than BMIPP, particularly for patients with ACS. ..
  30. Hougaard K, Kuur E. 99mTc-SN-pyrophosphate scintigraphy following traumatic posterior dislocation of the hip. Injury. 1988;19:389-92 pubmed
    ..It is concluded that 99mTc-SN-pyrophosphate scintigraphy 12 weeks after traumatic dislocation of the hip was unable to identify hips at risk of later development of avascular necrosis of the head of the femur...
  31. Davidson R, Lin D, Klima M. Temporal changes in myocardial uptake on serial bone scans in two cases of presumed senile cardiac amyloidosis. Clin Nucl Med. 1993;18:858-62 pubmed
    ..Presumptive diagnoses of senile cardiac amyloidosis were made based on clinical findings, noninvasive imaging, and comparison with a historic cohort at the Veterans Administration Medical Center in Houston. ..
  32. Chen W, Dilsizian V. Molecular imaging of amyloidosis: will the heart be the next target after the brain?. Curr Cardiol Rep. 2012;14:226-33 pubmed publisher
    ..With the recent success of visualizing deposition of amyloid ? in the brain, the US Food and Drug Administration-approved PET imaging agent (18)F-florbetapir may be used to target cardiac amyloidosis next. ..
  33. Khaw B, Haber E. Imaging necrotic myocardium: detection with 99mTc-pyrophosphate and radiolabeled antimyosin. Cardiol Clin. 1989;7:577-88 pubmed
    ..The two agents in clinical use, 99mTc-Pyrophosphate and radiolabeled antimyosin, are discussed. ..
  34. Hauzeur J, Pasteels J, Orloff S. Bilateral non-traumatic aseptic osteonecrosis in the femoral head. An experimental study of incidence. J Bone Joint Surg Am. 1987;69:1221-5 pubmed
    ..The intramedullary pressure in the intertrochanteric area was recorded in each hip, and no correlation was found with the radiographic stage or with pain. ..
  35. Kobayashi H, Itoh T, Kato T, Fujita Y, Murata R, Tanabe M, et al. [A case of liposarcoma; the concentration of Tc-PYP and Ga-citrate was the useful indicator of the effect of transarterial embolization]. Rinsho Hoshasen. 1990;35:1101-4 pubmed
    ..To our knowledge, this is the first case that concentration of Tc-PYP and Ga-citrate was the useful indicator of the effect of transarterial embolization. ..
  36. Lee D, Lee M, Chung J, Koh C, Moon D. Localization of In-111 antimyosin Fab and 99mTc-pyrophosphate in reperfusion myocardial infarction model. Korean J Intern Med. 1990;5:15-22 pubmed
    ..This study suggests that In-111 antimyosin Fab is a specific and quantitative tool in the evaluation of myocardial necrosis. ..
  37. Murakami J, Toyama T, Adachi H, Hoshizaki H, Oshima S, Kurabayashi M. Important factors for salvaging myocardium in patients with acute myocardial infarction. J Cardiol. 2008;52:269-75 pubmed publisher
    ..006). The presence of high TIMI grade before PCI and prodromal angina are very important for salvaging myocardium. Furthermore, administration of nicorandil is important in salvaging myocardium in patients with AMI. ..
  38. Bokhari S, Morgenstern R, Weinberg R, Kinkhabwala M, Panagiotou D, Castaño A, et al. Standardization of 99mTechnetium pyrophosphate imaging methodology to diagnose TTR cardiac amyloidosis. J Nucl Cardiol. 2018;25:181-190 pubmed publisher
  39. Thøgersen K, Simonsen J, Hvidsten S, Gerke O, Jacobsen S, Høilund Carlsen P, et al. Quantitative 3D scintigraphy shows increased muscular uptake of pyrophosphate in idiopathic inflammatory myopathy. EJNMMI Res. 2017;7:97 pubmed publisher
    ..Hence, tomographic nuclear imaging allowing for quantification of the 99mTc-PYP uptake might contribute to the diagnosis of IIM, and SPECT/CT of the lower body might suffice. ..
  40. Janssen S, Piers D, van Rijswijk M, Meijer S, Mandema E. Soft-tissue uptake of 99mTc-diphosphonate and 99mTc-pyrophosphate in amyloidosis. Eur J Nucl Med. 1990;16:663-70 pubmed
    ..99mTc-MDP images showed a better contrast than 99mTc-PYP images, although there was no difference in the extent or the intensity of soft-tissue uptake. ..
  41. Sakata K, Yoshida H, Ono N, Ohtani S, Mori N, Yokoyama S, et al. Implications of delayed image on simultaneous thallium-201/technetium-99m pyrophosphate dual emission computed tomography early after acute myocardial infarction. Jpn Circ J. 1993;57:27-36 pubmed
    ..In addition, the redistribution patterns on thallium-201 emission computed tomography early after intracoronary thrombolysis can be helpful in identifying patients with successful early recanalization and a high risk subset. ..
  42. Lin W, Wang S. The influence of two bone agents (99Tcm-pyrophosphate and 99Tcm-methylenediphosphonate) on quantitative sacroiliac joint scintigraphy. Nucl Med Commun. 1996;17:1035-8 pubmed
    ..1 on both sides using Student's t-tests for unpaired data). ..
  43. Taki J, Taki S, Ichiyanagi K, Akashi Y, Hisada K. Acute subendocardial infarction with diffuse intense Tc-99m PYP uptake and minimal Tl-201 abnormality. Clin Nucl Med. 1992;17:643-5 pubmed
    ..Tl-201 myocardial perfusion scintigraphy at rest revealed a minimal perfusion abnormality with decreased apical uptake in the lateral view. Because of these findings, diffuse subendocardial infarction was suggested. ..
  44. Kubota M. [Quantitative assessment of the infarct size with the unfolded map method of 201Tl myocardial SPECT in patient with acute myocardial infarction]. Kaku Igaku. 1992;29:333-46 pubmed
    ..595) of 99mTc PYP SPECT. In conclusion, although the unfolded map method of 201Tl SPECT has the tendency which overestimate infarct size, it is accurate and clinically reliable method in estimating infarct size. ..
  45. Carpeggiani C, L Abbate A, Marzullo P, Buzzigoli G, Parodi O, Sambuceti G, et al. Multiparametric approach to diagnosis of non-Q-wave acute myocardial infarction. Am J Cardiol. 1989;63:404-8 pubmed
    ..Thus, by conventional enzymatic approach, diagnosis of non-Q-wave infarction can be missed in a sizable number of patients and present important clinical implications...
  46. Baulieu F, Baulieu J, Valmalle R, Secchi V, Pottier J, Dorval E, et al. [Scintigraphic detection of gastrointestinal hemorrhage. Value and limitations]. Ann Chir. 1992;46:319-23 pubmed
    ..It helps to guide further investigations of the bleeding site. This non invasive method should be performed more quickly to help to localize intestinal bleeding which poses a diagnostic problem...
  47. Yip T, Houle S, Hayes G, Forrest I, Nelson L, Walker P. Quantitation of skeletal muscle necrosis using 99Tcm-pyrophosphate with SPECT in a canine model. Nucl Med Commun. 1990;11:143-9 pubmed
    ..The results were compared with quantitation using computerized planimetry with nitroblue tetrazolium staining (correlation coefficient = 0.93). PPi with SPECT is an accurate method for quantiating muscle necrosis...
  48. Shih W, Flueck J, O Connor W, Domstad P. Extensive extraosseous localization of bone imaging agent in a patient with renal failure and rhabdomyolysis accompanied by combined hypercalcemia and hyperphosphatemia. Clin Nucl Med. 1989;14:163-7 pubmed
    ..The Tc-99m PYP imaging study is useful and sensitive in the detection of extraosseous tissue calcification and monitoring of the disease process...
  49. Angomachalelis N, Hourzamanis A, Salem N, Vakalis D, Serasli E, Efthimiadis T, et al. Pericardial effusion concomitant with specific heart muscle disease in systemic sarcoidosis. Postgrad Med J. 1994;70 Suppl 1:S8-12 pubmed
    ..This observation has not been well established previously in the literature...
  50. Taillefer R. Detection of myocardial necrosis and inflammation by nuclear cardiac imaging. Cardiol Clin. 1994;12:289-302 pubmed
    ..When appropriately applied, radionuclide imaging with infarct-avid agents may provide very helpful clinical information...
  51. Fujii T, Tanaka M, Yazaki Y, Kitabayashi H, Koizumi T, Hongo M, et al. [Myocardial scintigraphic studies with 123I-MIBG, 201Tl and 99mTc-PYP in patients with cardiac amyloidosis]. Kaku Igaku. 1997;34:1033-9 pubmed
    ..And MIBG myocardial scintigraphy may provide useful information about sympathetic nerve abnormalities which vary with type of the fibril protein, clinical syndromes and disease process of cardiac amyloidosis...
  52. Haraki T, Ueda K, Shintani H, Hayashi T, Taki J, Mabuchi H. Spontaneous development of left ventricular aneurysm in a patient with untreated cardiac sarcoidosis. Circ J. 2002;66:519-21 pubmed
    ..Thallium-201 SPECT revealed a perfusion defect in the anterolateral wall, and abnormal uptake of technetium-99m pyrophosphate was seen, especially in the borders of the defect lesion...
  53. Miyazaki S, Kamiishi T, Hosokawa N, Komura M, Konagai H, Sagai H, et al. Reversible left ventricular dysfunction "takotsubo" cardiomyopathy associated with hyperthyroidism. Jpn Heart J. 2004;45:889-94 pubmed
    ..The wall motion abnormality disappeared entirely after 1 week in hospital. We report a case of transient left ventricular dysfunction, so called "takotsubo" cardiomyopathy, associated with hyperthyroidism...
  54. Isberg B, Paul C, Jonsson L, Svahn U. Myocardial toxicity of high-dose cyclophosphamide in rabbits treated with daunorubicin. Cancer Chemother Pharmacol. 1991;28:171-80 pubmed
    ..We conclude that high-dose cyclophosphamide treatment on a dose schedule similar to that used prior to bone marrow transplantation and given soon after long-term daunorubicin therapy is considerably cardiotoxic...
  55. Bloom R, Gheorghiu D, Krausz Y. Lymphatic opacification in the prosthetic hip. Skeletal Radiol. 1991;20:43-5 pubmed
    ..It is concluded that lymphatic opacification during arthrography for pain following total hip prosthesis is a valuable ancillary sign of loosening...
  56. Aizawa N, Suzuki Y, Akashi T, Kamei T, Uchiyama F, Hara Y, et al. [Clinical usefulness of scintigraphy with 99m technetium phosphates in rhabdomyolysis]. Kaku Igaku. 1990;27:801-7 pubmed
    ..We conclude that 99mTechnetium phosphate bone scan is useful in clinically suspected rhabdomyolysis as a diagnostic test and as a test to localize and quantitate the muscular involvement...
  57. Schümichen C, Krause T. [Scintigraphic findings in myocardial infarct]. Radiologe. 1988;28:409-16 pubmed
    ..This technique allows recognition even of nontransmural infarctions, involvement of the right ventricle, subendocardial necroses, and ischemic injuries in unstable angina pectoris...
  58. Hammond J, Ward C. High-voltage electrical injuries: management and outcome of 60 cases. South Med J. 1988;81:1351-2 pubmed
    ..Sepsis or wound infection occurred in one third and neurologic impairment in one fourth of the patients. Despite this, most patients are able to return to gainful employment...
  59. Kobayashi H, Miyagi M, Nakajima H, Watanabe T, Nagai Y, Ibukiyama C. [Evaluation of myocardial viability and efficacy of reperfusion therapy by dual-SPECT using 99mTc-PYP and 201Tl in acute myocardial infarction]. Kaku Igaku. 1994;31:1227-36 pubmed
    ..63, p < 0.01), was found between reperfusion time from cardiac event within 9 hours and the value of (100--the Y-ratio)...
  60. Okuda K, Nohara R, Fujita M, Tamaki N, Konishi J, Sasayama S. Technetium-99m-pyrophosphate uptake as an indicator of myocardial injury without infarct. J Nucl Med. 1994;35:1366-70 pubmed
    ..In this paper, 99mTc-PYP uptake was determined in various models of myocardial ischemia of short duration to examine its applicability to the assessment of myocardial viability...
  61. Collazo De La Maza A, Borrón Molinos M, Cordiés Justiz N, Pimentel González G, Sánchez Monzón I. [Radionuclide study of cutaneous melanomas with 99m Tc-HMPAO: visualization of metastases and recurrence]. Rev Esp Med Nucl. 1999;18:16-20 pubmed
    ..The gammagraphic studies could be very important for the staging of the disease and early detection of metastases and recurrent lesions...
  62. Kawano M, Taki J, Kinuya S, Higuchi T, Nakajima K, Miyazaki Y, et al. [Improvement of 99mTc-pyrophosphate scintigraphy in detection of acute myocardial infarction: combined with 99mTc-tetrofosmin]. Kaku Igaku. 2001;38:707-13 pubmed
    ..However, 201Tl is not available on emergent situation. We proposed a new method for detection of AMI combined 99mTc-PYP with 99mTc-tetrofosmin (TF)...
  63. Hiroe M, Nagata M, Sekiguchi M, Ohta Y, Kusakabe K, Shigeta A, et al. [Radionuclide assessment of cardiac involvement in patients with sarcoidosis]. Nihon Kyobu Shikkan Gakkai Zasshi. 1990;28:56-64 pubmed
    ..These data suggest that nuclear study is a useful tool for diagnosing cardiac sarcoidosis, evaluating therapeutic effectiveness and long-term follow-up in patients with sarcoidosis...
  64. Yang D, Jain C, Patel D, Gould L, Schaefer H, Maghazeh P, et al. Use of i.v. radionuclide total body arteriography to evaluate arterial bypass shunts--a new method--a review of several cases. Angiology. 1990;41:745-52 pubmed
    ..It is a simple and a virtually noninvasive procedure, particularly useful for preoperative workups and postoperative follow-ups...
  65. Tal A, Leiberman A, Margulis G, Sofer S. Ventricular dysfunction in children with obstructive sleep apnea: radionuclide assessment. Pediatr Pulmonol. 1988;4:139-43 pubmed
    ..It is concluded that right ventricular function may be compromised in children with obstructive sleep apnea secondary to adenotonsillar hypertrophy, even before clinical signs of cardiac involvement are present...
  66. Howarth D, Coote D. "Window on the heart" technique for diagnosis of recent myocardial infarction using Tc-99m pyrophosphate SPECT subtraction imaging. Clin Nucl Med. 1995;20:1-4 pubmed
    ..This technique has diagnostic use in difficult clinical cases, and where avid radiotracer uptake in the ribs or sternum obscures the underlying myocardium...
  67. Tange S, Kondo C, Ohta Y, Kusakabe K, Shigeta A, Uchida T, et al. [Significance of Tc-99m pyrophosphate accumulation in unstable angina: clinical characteristics and evidence for myocardial stunning]. J Cardiol. 1993;23:19-28 pubmed
    ..8) (p < 0.025); whereas, WMI of the PYP(-)group showed no significant improvement (from 5.7 +/- 8.2 to 15.5 +/- 19.6). These data suggest that the area showing PYP(+) may represent stunned myocardium.(ABSTRACT TRUNCATED AT 400 WORDS)..
  68. Mones J, Carrio I, Sainz S, Berna L, Clave P, Liszkay M, et al. Gastric emptying of two radiolabelled antacids with simultaneous monitoring of gastric pH. Eur J Nucl Med. 1995;22:1123-8 pubmed
    ..A significant decrease in pH was observed 1 h after intake of the antacids, suggesting a possible rebound effect...
  69. Block T, Aarsvold J, Matthews K, Mintzer R, River L, Capelli Schellpfeffer M, et al. The 1995 Lindberg Award. Nonthermally mediated muscle injury and necrosis in electrical trauma. J Burn Care Rehabil. 1995;16:581-8 pubmed
    ..Thus the phenomenon of "progressive recognition" may be characteristically largely explained by the occurrence of nonthermally mediated tissue damage...
  70. von Kempis J, Kalden P, Gutfleisch J, Grimbacher B, Krause T, Uhl M, et al. Diagnosis of idiopathic myositis: value of 99mtechnetium pyrophosphate muscle scintigraphy and magnetic resonance imaging in targeted muscle biopsy. Rheumatol Int. 1998;17:207-13 pubmed
    ..Treatment with corticosteroids prior to histologic diagnosis may abolish inflammatory infiltrations in affected muscle tissue...
  71. Walker U, Garve K, Brink I, Miehle N, Peter H, Kelly T. 99mTechnetium pyrophosphate scintigraphy in the detection of skeletal muscle disease. Clin Rheumatol. 2007;26:1119-22 pubmed
  72. Huang C, Chen Y, Lin C, Hsiao Y, Sheu L, Tu M. A case of dermatomyositis with secondary Sjögren's Syndrome-diagnosis with follow-up study of technetium-99m pyrophosphate scintigraphy. Acta Neurol Taiwan. 2013;22:162-8 pubmed
    ..To report a case of dermatomyositis (DM) with secondary Sjögren's syndrome (SS) and propose the clinical application of technetium-99m pyrophosphate ((99m)Tc-PYP) scan...
  73. Miyagawa M, Tanada S, Hamamoto K. Scintigraphic evaluation of myocardial uptake of thallium 201 and technetium 99m pyrophosphate utilizing a rat model of chronic doxorubicin cardiotoxicity. Eur J Nucl Med. 1991;18:332-8 pubmed
    ..On the other hand, myocardial 99mTc-PPi images could be obtained only in rats with severe myocardial changes and hence would not useful for early detection...
  74. Takeda K, LaFrance N, Weisman H, Wagner H, Becker L. Comparison of indium-111 antimyosin antibody and technetium-99m pyrophosphate localization in reperfused and nonreperfused myocardial infarction. J Am Coll Cardiol. 1991;17:519-26 pubmed
    ..Histologic evidence of myocardial necrosis was found in virtually every sample with increased In-111 antimyosin antibody, Tc-99m pyrophosphate, or both.(ABSTRACT TRUNCATED AT 250 WORDS)..
  75. Stratmann H. Acute myocarditis versus myocardial infarction: evaluation and management of the young patient with prolonged chest pain--case reports. Angiology. 1988;39:253-8 pubmed
    ..These difficulties are illustrated by the 2 cases presented, and guidelines for diagnosis and treatment are given...
  76. Humphrey S, Inman R. Metastatic adenocarcinoma mimicking unilateral sacroiliitis. J Rheumatol. 1995;22:970-2 pubmed
    ..When progressive symptoms are unresponsive to conventional therapy, diagnosis should always be reconsidered, with appropriate imaging studies. We discuss mechanisms of joint space involvement and review the literature...
  77. Okuda K, Nohara R, Fujita M, Tamaki N, Konishi J, Sasayama S. Improvement of myocardial ischemic dysfunction with dichloroacetic acid: experimental study by repeated ischemia in dogs. J Cardiovasc Pharmacol. 1995;26:990-9 pubmed
    ..These findings suggest that the activation of glucose metabolism by DCA, which is impaired and reduced during ischemia and reperfusion, may be responsible for the improved myocardial function after reperfusion...
  78. Moore W. Choosing a nuclear medicine study for cardiovascular applications. Tex Heart Inst J. 1996;23:117-21 pubmed
    ..This article provides some background and guidelines to assist in the selection of radioisotopic procedures for cardiovascular applications, with the goal of directing the study to an individual patient's needs...
  79. Isoda H, Itagaki Y, Nomura N, Urushida T, Naitou A, Watanabe A, et al. Dual radionuclide single-photon emission computed tomography in the prediction of further ischemic risk after acute myocardial infarction. Ann Nucl Med. 1998;12:179-83 pubmed
  80. Redondo F, Gonzalez P, Ramirez A. [Myocardial pyrophosphate uptake in cardiac amyloidosis: report of case]. Rev Med Chil. 2002;130:315-8 pubmed
    ..A restrictive cardiomyopathy due to amyloid deposits was suspected. Myocardial pyrophosphate scintigraphy showed intense pyrophosphate uptake in the left ventricle wall. An abdominal fat tissue biopsy was positive for amyloid deposits...
  81. Santoro G, Buonamici P, Bisi G, Sciagra R, Leoncini M, Meldolesi U, et al. [Myocardial scintigraphy using 99m-technetium pyrophosphate in the diagnosis of acute myocardial infarct. Comparison of planar and tomographic imaging]. G Ital Cardiol. 1989;19:295-302 pubmed
    ..A bidimensional echocardiogram was carried out on 38 patients: an alteration of left ventricular regional wall motion was present in 30 subjects; in one patient diffuse hypokinesia was present.(ABSTRACT TRUNCATED AT 250 WORDS)..
  82. Owunwanne A, Malki A, Sadek S, El Gazzar A, Yacoub T, Abdel Dayem H. Investigative study of radiopharmaceuticals useful for imaging skeletal muscle injury in experimental animals. Am J Physiol Imaging. 1989;4:62-5 pubmed
    ..Hence, In-111 antimyosin is a good radiopharmaceutical for studying the severity and prognosis of skeletal muscle injury...
  83. Lomena F, Rosello R, Pons F, Grau M, Garcia A, Catafau A, et al. Abnormal scintigraphic evolution in AA hepatic amyloidosis. Clin Nucl Med. 1988;13:194-6 pubmed
    ..A mechanism might exist, other than the affinity of amyloid to calcium, which would explain the extraosseous uptake of pyrophosphates and diphosphonates in organs and soft tissues affected by systemic amyloidosis...
  84. Tanaka M, Hongo M, Kinoshita O, Takabayashi Y, Fujii T, Yazaki Y, et al. Iodine-123 metaiodobenzylguanidine scintigraphic assessment of myocardial sympathetic innervation in patients with familial amyloid polyneuropathy. J Am Coll Cardiol. 1997;29:168-74 pubmed
    ..This study attempted to assess myocardial sympathetic innervation using iodine-123 (I-123) metaidobenzylguanidine (MIBG) imaging in patients with familial amyloid polyneuropathy...
  85. Maurer A, Urbain J, Krevsky B, Knight L, Revesz G, Brown K. Effects of in vitro versus in vivo red cell labeling on image quality in gastrointestinal bleeding studies. J Nucl Med Technol. 1998;26:87-90 pubmed
    ..This study compares in vivo and in vitro methods using both subjective and objective measurements of image quality...
  86. Maruyama Y, Kato T, Ito H, Tanaka S, Yoshimoto N, Kishi Y, et al. New method of estimating myocardial infarct size using technetium-99m pyrophosphate and thallium-201 dual single photon emission computed tomography imaging. Jpn Circ J. 1999;63:155-9 pubmed
    ..As %MI correlated well with these markers, it is considered that %MI will be useful for estimating infarct size and predicting the severity of left ventricular dysfunction in the early stage of acute myocardial infarction...
  87. Miron S, Wiesen E, Feiglin D, Cohen A, Bellon E. Generation of parametric images during routine Tc-99m PYP inhalation/Tc-99m MAA perfusion lung scintigraphy. Technical note. Clin Nucl Med. 1991;16:501-5 pubmed
    ..These images highlight areas of ventilation/perfusion incongruence--mismatch or reverse mismatch--that may sometimes be difficult to detect on conventional images...
  88. Nakata T, Sakakibara T, Noto T, Shoji T, Tsuda T, Kubota M, et al. Myocardial distribution of indium-111-antimyosin Fab in acute inferior and right ventricular infarction: comparison with technetium-99m-pyrophosphate imaging and histologic examination. J Nucl Med. 1991;32:865-7 pubmed
    ..Tissue from the 2-yr-old infarction was not identified by this technique...
  89. Knesewitsch P, Göldel N, Fritsch S, Moser E. [Evaluation of adriamycin cardiotoxicity using equilibrium radionuclide ventriculography. II. Results during exercise]. Nuklearmedizin. 1987;26:212-9 pubmed
    ..Therefore, E-ERNV does not have a significantly higher sensitivity in the early detection of ADM-CMP than R-ERNV and is not required for the surveillance of patients under ADM therapy...
  90. Taki J, Nakajima K. [99mTc-PYP scintigraphy: its usefulness and pitfalls]. Nihon Rinsho. 2003;61 Suppl 4:323-6 pubmed
  91. Sone T. [201Tl, 99mTc-PYP dual SPECT]. Nihon Rinsho. 2003;61 Suppl 4:347-52 pubmed
  92. Aksu B, Durmus Altun G, Ustun F, Torun N, Kanter M, Umit H, et al. A new imaging modality in detection of caustic oesophageal injury: Technetium-99m pyrophosphate scintigraphy. Int J Pediatr Otorhinolaryngol. 2009;73:409-15 pubmed publisher
    ..The purpose of the study is to determine the value and sensitivity of Tc-99m pyrophosphate (99mTc-PYP) scintigraphy for the detection of caustic oesophageal injury...