polyphosphates

Summary

Summary: Linear polymers in which orthophosphate residues are linked with energy-rich phosphoanhydride bonds. They are found in plants, animals, and microorganisms.

Top Publications

  1. Tu Y, Schuler A. Low acetate concentrations favor polyphosphate-accumulating organisms over glycogen-accumulating organisms in enhanced biological phosphorus removal from wastewater. Environ Sci Technol. 2013;47:3816-24 pubmed publisher
    ..Full-scale systems typically have lower in-reactor acetate concentrations than laboratory SBRs, and so, previous laboratory studies may have overestimated the practical importance of GAOs as causes of EBPR failure...
  2. Shi T, Fu T, Xie J. Polyphosphate deficiency affects the sliding motility and biofilm formation of Mycobacterium smegmatis. Curr Microbiol. 2011;63:470-6 pubmed publisher
    ..This investigation provides novel recognition about the role of Rv1026, which provides novel clues for further study on the physiological role of Rv1026 in M. tuberculosis...
  3. Negoda A, Negoda E, Reusch R. Importance of oligo-R-3-hydroxybutyrates to S. lividans KcsA channel structure and function. Mol Biosyst. 2010;6:2249-55 pubmed publisher
    ..The results indicate that cOHB facilitates the incorporation and/or retention of polyP and plays a critical role in maintaining the flexible polyP molecule in an optimal transbilayer orientation for efficient K(+) transport...
  4. Ghosh S, Shukla D, Suman K, Lakshmi B, Manorama R, Kumar S, et al. Inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levels. Blood. 2013;122:1478-86 pubmed publisher
    ..Taken together, our data suggest a novel role for IP6K1 in regulation of mammalian hemostasis via its control of platelet polyP levels. ..
  5. Usui Y, Uematsu T, Uchihashi T, Takahashi M, Ishizuka M, Doto R, et al. Inorganic polyphosphate induces osteoblastic differentiation. J Dent Res. 2010;89:504-9 pubmed publisher
    ..Promotion of alveolar bone regeneration was observed in Poly(P)-treated beagle dogs. These findings suggest that Poly(P) induces osteoblastic differentiation and bone mineralization, and acts as a resource for mineralization...
  6. Thayil S, Morrison N, Schechter N, Rubin H, Karakousis P. The role of the novel exopolyphosphatase MT0516 in Mycobacterium tuberculosis drug tolerance and persistence. PLoS ONE. 2011;6:e28076 pubmed publisher
    ..We conclude that exopolyphosphatase is required for long-term survival of M. tuberculosis in necrotic lung lesions...
  7. Eldarov M, Baranov M, Dumina M, Shgun A, Andreeva N, Trilisenko L, et al. Polyphosphates and exopolyphosphatase activities in the yeast Saccharomyces cerevisiae under overexpression of homologous and heterologous PPN1 genes. Biochemistry (Mosc). 2013;78:946-53 pubmed publisher
    ..chrysogenum, suggesting the absence of the active form of PPN1 in this transformant. ..
  8. Liu J, Huang W, Pang Y, Zhu X, Zhou Y, Yan D. Hyperbranched polyphosphates for drug delivery application: design, synthesis, and in vitro evaluation. Biomacromolecules. 2010;11:1564-70 pubmed publisher
    ..Therefore, on the basis of its biocompatibility and biodegradability, HPHEEP could provide a charming opportunity to design some excellent drug delivery systems for therapeutic applications...
  9. Morimoto D, Tomita T, Kuroda S, Higuchi C, Kato S, Shiba T, et al. Inorganic polyphosphate differentiates human mesenchymal stem cells into osteoblastic cells. J Bone Miner Metab. 2010;28:418-23 pubmed publisher
    The existence of inorganic polyphosphates [poly(P)] in human cells has been demonstrated. In osteoblasts, it is suggested that the concentration of cellular poly(P) is relatively high...

More Information

Publications62

  1. Pavlov E, Aschar Sobbi R, Campanella M, Turner R, Gomez Garcia M, Abramov A. Inorganic polyphosphate and energy metabolism in mammalian cells. J Biol Chem. 2010;285:9420-8 pubmed publisher
    ..Enzymatic depletion of poly P from cells significantly altered the rate of ATP metabolism. We propose the existence of a feedback mechanism where poly P production and cell energy metabolism regulate each other...
  2. Morrissey J, Choi S, Smith S. Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation. Blood. 2012;119:5972-9 pubmed publisher
    ..The detailed molecular mechanisms by which polyphosphate modulates blood clotting reactions remain to be elucidated...
  3. Orell A, Navarro C, Rivero M, Aguilar J, Jerez C. Inorganic polyphosphates in extremophiles and their possible functions. Extremophiles. 2012;16:573-83 pubmed publisher
    ..However, the lack of a canonical polyP synthase in Crenarchaea, which greatly accumulate polyP, strongly suggests that in this phylum a different enzyme may be in charge of its synthesis...
  4. Saiardi A. How inositol pyrophosphates control cellular phosphate homeostasis?. Adv Biol Regul. 2012;52:351-9 pubmed publisher
    ..Furthermore, inositol pyrophosphates influence inorganic polyphosphates (polyP) synthesis...
  5. Grillo Puertas M, Villegas J, Rintoul M, Rapisarda V. Polyphosphate degradation in stationary phase triggers biofilm formation via LuxS quorum sensing system in Escherichia coli. PLoS ONE. 2012;7:e50368 pubmed publisher
    ..According to our results, phosphate concentration of the culture media should be carefully considered in bacterial adhesion and virulence studies...
  6. Karp H, Kemi V, Lamberg Allardt C, Kärkkäinen M. Mono- and polyphosphates have similar effects on calcium and phosphorus metabolism in healthy young women. Eur J Nutr. 2013;52:991-6 pubmed publisher
    Phosphate (Pi) salts, often mono- (MP) or polyphosphates (PP), are commonly used as additives in the food industry. Previous studies have shown that the effects of MP and PP on calcium (Ca) and phosphorus (P) metabolism may differ...
  7. Segawa S, Fujiya M, Konishi H, Ueno N, Kobayashi N, Shigyo T, et al. Probiotic-derived polyphosphate enhances the epithelial barrier function and maintains intestinal homeostasis through integrin-p38 MAPK pathway. PLoS ONE. 2011;6:e23278 pubmed publisher
    ..This study, for the first time, demonstrated that poly P is the molecule responsible for maintaining intestinal barrier actions which are mediated through the intestinal integrin ?1-p38 MAPK...
  8. Yang Z, Zhou Y, Yang Y, Jin D. Polyphosphate binds to the principal sigma factor of RNA polymerase during starvation response in Helicobacter pylori. Mol Microbiol. 2010;77:618-27 pubmed publisher
    ..pylori to mediate gene expression during starvation/stress. The putative 'region P' is present in sigma factors of other human pathogens, suggesting that the uncovered interaction might be a general strategy employed by other pathogens...
  9. Riley A, Wang H, Weaver J, Shears S, Potter B. First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase. Chem Commun (Camb). 2012;48:11292-4 pubmed publisher
    We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an ?-phosphonoacetic acid (PA) ester...
  10. Docampo R, Ulrich P, Moreno S. Evolution of acidocalcisomes and their role in polyphosphate storage and osmoregulation in eukaryotic microbes. Philos Trans R Soc Lond B Biol Sci. 2010;365:775-84 pubmed publisher
    ..Storage of phosphate and cations may represent the ancestral physiological function of acidocalcisomes, with cation and pH homeostasis and osmoregulatory functions derived following the divergence of prokaryotes and eukaryotes...
  11. Nakamura M, Imanaka T, Sakamoto A. Diquafosol ophthalmic solution for dry eye treatment. Adv Ther. 2012;29:579-89 pubmed publisher
    ..Various types of dry eye treatment drugs have been developed. This review summarizes the basic and clinical research carried out in the development of diquafosol for ophthalmic use...
  12. Moreno Sanchez D, Hernandez Ruiz L, Ruiz F, Docampo R. Polyphosphate is a novel pro-inflammatory regulator of mast cells and is located in acidocalcisomes. J Biol Chem. 2012;287:28435-44 pubmed publisher
    ..The results suggest that mast cells polyP could be an important mediator of their pro-inflammatory and pro-coagulant activities...
  13. Ward S, Heintz J, Albrecht R, Talaat A. Single-cell elemental analysis of bacteria: quantitative analysis of polyphosphates in Mycobacterium tuberculosis. Front Cell Infect Microbiol. 2012;2:63 pubmed publisher
    ..step in developing a better understanding of the role that components of the intracellular milieu, including polyphosphates and biometals, play in the pathogenesis of M...
  14. Rooney P, Ayong L, Tobin C, Moreno S, Knoll L. TgVTC2 is involved in polyphosphate accumulation in Toxoplasma gondii. Mol Biochem Parasitol. 2011;176:121-6 pubmed publisher
    ..The TgVTC2 locus was refractory to knockout, and may be essential. Analysis of this TgVTC2 mutant will facilitate dissection of the T. gondii polyphosphate synthesis pathway...
  15. Frenzel E, Letzel T, Scherer S, Ehling Schulz M. Inhibition of cereulide toxin synthesis by emetic Bacillus cereus via long-chain polyphosphates. Appl Environ Microbiol. 2011;77:1475-82 pubmed publisher
    ..These data illustrate the potential of polyphosphate formulations to reduce the risk of cereulide synthesis in food and may contribute to targeted hurdle concepts...
  16. Faxälv L, Boknäs N, Strom J, Tengvall P, Theodorsson E, Ramstrom S, et al. Putting polyphosphates to the test: evidence against platelet-induced activation of factor XII. Blood. 2013;122:3818-24 pubmed publisher
    The recent claim that stimulated platelets activate the intrinsic pathway of coagulation by the release of polyphosphates has been considered a breakthrough in hemostasis research...
  17. Ramos I, Miranda K, Pace D, Verbist K, Lin F, Zhang Y, et al. Calcium- and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADP. Biochem J. 2010;429:485-95 pubmed publisher
  18. Puy C, Tucker E, Wong Z, Gailani D, Smith S, Choi S, et al. Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates. J Thromb Haemost. 2013;11:1341-52 pubmed publisher
    Inorganic polyphosphates (polyP), which are secreted by activated platelets (short-chain polyP) and accumulate in some bacteria (long-chain polyP), support the contact activation of factor XII (FXII) and accelerate the activation of FXI.
  19. Kulakovskaya T, Lichko L, Vagabov V, Kulaev I. Inorganic polyphosphates in mitochondria. Biochemistry (Mosc). 2010;75:825-31 pubmed
    Current data concerning the crucial role of inorganic polyphosphates (polyP) in mitochondrial functions and dysfunctions in yeast and animal cells are reviewed...
  20. Holmström K, Marina N, Baev A, Wood N, Gourine A, Abramov A. Signalling properties of inorganic polyphosphate in the mammalian brain. Nat Commun. 2013;4:1362 pubmed publisher
    ..Together, these results suggest a role for polyphosphate as a mediator of astroglial signal transmission in the mammalian brain...
  21. Choi S, Smith S, Morrissey J. Polyphosphate is a cofactor for the activation of factor XI by thrombin. Blood. 2011;118:6963-70 pubmed publisher
    ..We therefore propose that polyphosphate is a natural cofactor for factor XI activation in plasma that may help explain the role of factor XI in hemostasis and thrombosis...
  22. Gomes F, Carvalho D, Peron A, Saito K, Miranda K, Machado E. Inorganic polyphosphates are stored in spherites within the midgut of Anticarsia gemmatalis and play a role in copper detoxification. J Insect Physiol. 2012;58:211-9 pubmed publisher
    Inorganic polyphosphates (PolyP) are widespread molecules that have been shown to play a role in metal detoxification and heavy-metal tolerance...
  23. Docampo R, Moreno S. Acidocalcisomes. Cell Calcium. 2011;50:113-9 pubmed publisher
    ..Acidocalcisomes interact with other organelles in a number of organisms suggesting their association with the endosomal/lysosomal pathway, and are considered part of the lysosome-related group of organelles...
  24. Achbergerová L, Nahalka J. Polyphosphate--an ancient energy source and active metabolic regulator. Microb Cell Fact. 2011;10:63 pubmed publisher
    ..At the end of the review, a hypothesis is discussed in view of synthetic biology applications that states polyphosphate and calcium-rich organelles have endosymbiotic origins from ancient protocells that metabolized polyphosphate...
  25. Caen J, Wu Q. Hageman factor, platelets and polyphosphates: early history and recent connection. J Thromb Haemost. 2010;8:1670-4 pubmed publisher
    ..Inorganic polyphosphates (poly P) are polymers that consist of many phosphate residues linked by phosphoanhydride bonds...
  26. Boutte C, Henry J, Crosson S. ppGpp and polyphosphate modulate cell cycle progression in Caulobacter crescentus. J Bacteriol. 2012;194:28-35 pubmed publisher
    ..Furthermore, we show that swarmer cells produce more ppGpp than stalked cells upon starvation. These results provide evidence that ppGpp and polyP are cell-type-specific developmental regulators...
  27. Gangaiah D, Liu Z, Arcos J, Kassem I, Sanad Y, Torrelles J, et al. Polyphosphate kinase 2: a novel determinant of stress responses and pathogenesis in Campylobacter jejuni. PLoS ONE. 2010;5:e12142 pubmed publisher
    ..Campylobacter jejuni, an important cause of foodborne gastroenteritis in humans, possesses homologs of both ppk1 and ppk2. ppk1 has been previously shown to impact the pathobiology of C. jejuni...
  28. Mutch N, Engel R, Uitte de Willige S, Philippou H, Ariens R. Polyphosphate modifies the fibrin network and down-regulates fibrinolysis by attenuating binding of tPA and plasminogen to fibrin. Blood. 2010;115:3980-8 pubmed publisher
    ..These data show that polyP directly influences fibrin architecture and attenuates fibrinolysis through reduced binding of fibrinolytic proteins...
  29. Ohashi K, Kawai S, Murata K. Identification and characterization of a human mitochondrial NAD kinase. Nat Commun. 2012;3:1248 pubmed publisher
    ..These observations provide insights into eukaryotic NADP(+) biosynthesis, which has pivotal roles in cells and organelles...
  30. Kamiya K, Nakanishi M, Ishii R, Kobashi H, Igarashi A, Sato N, et al. Clinical evaluation of the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome: a prospective, randomized, multicenter study. Eye (Lond). 2012;26:1363-8 pubmed publisher
    ..To assess the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome...
  31. Brock J, Schulz Vogt H. Sulfide induces phosphate release from polyphosphate in cultures of a marine Beggiatoa strain. ISME J. 2011;5:497-506 pubmed publisher
    ..This physiological reaction is a yet unknown mode of bacterial polyphosphate usage and provides a new explanation for high phosphate concentrations in sulfidic marine sediments...
  32. Moon J, Park J, Lee J. Antibacterial action of polyphosphate on Porphyromonas gingivalis. Antimicrob Agents Chemother. 2011;55:806-12 pubmed publisher
    ..Collectively, poly(P) is bactericidal against P. gingivalis, in which hemin/heme utilization is disturbed and oxidative stress is increased by poly(P)...
  33. Müller F, Renne T. Platelet polyphosphates: the nexus of primary and secondary hemostasis. Scand J Clin Lab Invest. 2011;71:82-6 pubmed publisher
    ..We found that platelets release polyphosphates, linear inorganic polymers of 60-100 phosphate residues that directly bound to and activated factor XII...
  34. Zeng W, Sun L, Jiang X, Chen X, Hou F, Adhikari A, et al. Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity. Cell. 2010;141:315-30 pubmed publisher
    ..Our results delineate the mechanism of RIG-I activation, identify CARD domains as a ubiquitin sensor, and demonstrate that unanchored K63-polyubiquitin chains are signaling molecules in antiviral innate immunity...
  35. Ramos I, Miranda K, Ulrich P, Ingram P, LEFURGEY A, Machado E, et al. Calcium- and polyphosphate-containing acidocalcisomes in chicken egg yolk. Biol Cell. 2010;102:421-34 pubmed publisher
  36. Nocek B, Kochinyan S, Proudfoot M, Brown G, Evdokimova E, Osipiuk J, et al. Polyphosphate-dependent synthesis of ATP and ADP by the family-2 polyphosphate kinases in bacteria. Proc Natl Acad Sci U S A. 2008;105:17730-5 pubmed publisher
    ..Thus, the PPK2s represent a molecular mechanism, which potentially allow bacteria to use polyP as an intracellular energy reserve for the generation of ATP and survival...
  37. Lorenz B, Schroder H. Mammalian intestinal alkaline phosphatase acts as highly active exopolyphosphatase. Biochim Biophys Acta. 2001;1547:254-61 pubmed
    Recent results revealed that inorganic polyphosphates (polyP), being energy-rich linear polymers of orthophosphate residues known from bacteria and yeast, also exist in higher eukaryotes...
  38. Pestov N, Kulakovskaya T, Kulaev I. Inorganic polyphosphate in mitochondria of Saccharomyces cerevisiae at phosphate limitation and phosphate excess. FEMS Yeast Res. 2004;4:643-8 pubmed
    ..Fast hydrolysis of polyP was observed after sonication of isolated mitochondria. Probably, the accumulation of polyP in mitochondria depended on the proton-motive force of their membranes...
  39. Mino T. Microbial selection of polyphosphate-accumulating bacteria in activated sludge wastewater treatment processes for enhanced biological phosphate removal. Biochemistry (Mosc). 2000;65:341-8 pubmed
  40. Sureka K, Sanyal S, Basu J, Kundu M. Polyphosphate kinase 2: a modulator of nucleoside diphosphate kinase activity in mycobacteria. Mol Microbiol. 2009;74:1187-97 pubmed publisher
    ..Downregulation of ppk2 impairs survival of M. tuberculosis in macrophages, suggesting that PPK2 plays an important role in the physiology of the bacteria residing within macrophages...
  41. Kawazoe Y, Shiba T, Nakamura R, Mizuno A, Tsutsumi K, Uematsu T, et al. Induction of calcification in MC3T3-E1 cells by inorganic polyphosphate. J Dent Res. 2004;83:613-8 pubmed
    ..Poly(P)-dependent induction of polyphosphatase activities may therefore promote calcification in MC3T3-E1 cells...
  42. Ruiz F, Lea C, Oldfield E, Docampo R. Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes. J Biol Chem. 2004;279:44250-7 pubmed
    ..The results suggest that acidocalcisomes have been conserved during evolution from bacteria to humans...
  43. Kulaev I, Vagabov V, Kulakovskaya T, Lichko L, Andreeva N, Trilisenko L. The development of A. N. Belozersky's ideas in polyphosphate biochemistry. Biochemistry (Mosc). 2000;65:271-8 pubmed
    This review covers some trends and approaches to the study of inorganic polyphosphates that originated from the fruitful ideas and pioneering works of A. N. Belozersky...
  44. Ogawa N, DeRisi J, Brown P. New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis. Mol Biol Cell. 2000;11:4309-21 pubmed
    ..Taken together, the results reveal important new features of a genetic system that plays a critical role in P(i) acquisition and polyP metabolism in yeast...
  45. Shiba T, Itoh H, Kameda A, Kobayashi K, Kawazoe Y, Noguchi T. Polyphosphate:AMP phosphotransferase as a polyphosphate-dependent nucleoside monophosphate kinase in Acinetobacter johnsonii 210A. J Bacteriol. 2005;187:1859-65 pubmed
    ..The activity for AMP was about 10 times greater than that for GMP and 770 and about 1,100 times greater than that for UMP and CMP...
  46. Werner T, Amrhein N, Freimoser F. Novel method for the quantification of inorganic polyphosphate (iPoP) in Saccharomyces cerevisiae shows dependence of iPoP content on the growth phase. Arch Microbiol. 2005;184:129-36 pubmed
    ..These experimental procedures will be essential for the large-scale analysis of various mutant strains or the comparison of different growth conditions...
  47. Smith S, Mutch N, Baskar D, Rohloff P, Docampo R, Morrissey J. Polyphosphate modulates blood coagulation and fibrinolysis. Proc Natl Acad Sci U S A. 2006;103:903-8 pubmed
  48. Varela C, Mauriaca C, Paradela A, Albar J, Jerez C, Chavez F. New structural and functional defects in polyphosphate deficient bacteria: a cellular and proteomic study. BMC Microbiol. 2010;10:7 pubmed publisher
    ..The cause of this pleiotropy is not entirely understood...
  49. Thomas M, O Shea E. An intracellular phosphate buffer filters transient fluctuations in extracellular phosphate levels. Proc Natl Acad Sci U S A. 2005;102:9565-70 pubmed
  50. Saito K, Ohtomo R, Kuga Uetake Y, Aono T, Saito M. Direct labeling of polyphosphate at the ultrastructural level in Saccharomyces cerevisiae by using the affinity of the polyphosphate binding domain of Escherichia coli exopolyphosphatase. Appl Environ Microbiol. 2005;71:5692-701 pubmed
  51. Jäger S, Rasched G, Kornreich Leshem H, Engeser M, Thum O, Famulok M. A versatile toolbox for variable DNA functionalization at high density. J Am Chem Soc. 2005;127:15071-82 pubmed
    ..Our study provides a basis for establishing a generally applicable toolbox of enzymes, templates, and monomers for generating high-density functionalized DNAs for a broad range of applications...
  52. Yuan Q, Kubo T, Doi K, Morita K, Takeshita R, Katoh S, et al. Effect of combined application of bFGF and inorganic polyphosphate on bioactivities of osteoblasts and initial bone regeneration. Acta Biomater. 2009;5:1716-24 pubmed publisher
    ..It is anticipated that a combined application of bFGF and poly(P) can provide a novel method for bone regeneration in clinical use...
  53. Shiba T, Tsutsumi K, Yano H, Ihara Y, Kameda A, Tanaka K, et al. Inorganic polyphosphate and the induction of rpoS expression. Proc Natl Acad Sci U S A. 1997;94:11210-5 pubmed