sodium azide

Summary

Summary: A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed)

Top Publications

  1. Marino S, Marani L, Nazzaro C, Beani L, Siniscalchi A. Mechanisms of sodium azide-induced changes in intracellular calcium concentration in rat primary cortical neurons. Neurotoxicology. 2007;28:622-9 pubmed
    An intracellular calcium ([Ca(2+)](i)) increase is involved in sodium azide (NaN(3))-induced neurotoxicity, an in vitro model of brain ischemia...
  2. Szabados T, Dul C, Majtenyi K, Hargitai J, Penzes Z, Urbanics R. A chronic Alzheimer's model evoked by mitochondrial poison sodium azide for pharmacological investigations. Behav Brain Res. 2004;154:31-40 pubmed
    ..Inhibition of this complex could be evoked by chronic sodium azide (NaN(3)) administration in animals...
  3. Ammar R, Sghaier M, Boubaker J, Bhouri W, Naffeti A, Skandrani I, et al. Antioxidant activity and inhibition of aflatoxin B1-, nifuroxazide-, and sodium azide-induced mutagenicity by extracts from Rhamnus alaternus L. Chem Biol Interact. 2008;174:1-10 pubmed publisher
    ..The evaluation of the mutagenic and antimutagenic actions of the same extracts against the sodium azide (1.5 microg/plate)-induced mutagenicity was assayed using the Salmonella typhimurium assay system. The R...
  4. Swafford A, Bratz I, Knudson J, Rogers P, Timmerman J, Tune J, et al. C-reactive protein does not relax vascular smooth muscle: effects mediated by sodium azide in commercially available preparations. Am J Physiol Heart Circ Physiol. 2005;288:H1786-95 pubmed
    ..b>Sodium azide (NaN(3), 0.1%) is the preservative used for commercially available CRP and a potential source of NO...
  5. Bancirova M. Sodium azide as a specific quencher of singlet oxygen during chemiluminescent detection by luminol and Cypridina luciferin analogues. Luminescence. 2011;26:685-8 pubmed publisher
    ..g. superoxide dismutase (SOD) or sodium azide (NaN(3))...
  6. Gulluce M, Agar G, Aslan A, Karadayi M, Bozari S, Orhan F. Protective effects of methanol extracts from Cladonia rangiformis and Umbilicaria vellea against known mutagens sodium azide and 9-aminoacridine. Toxicol Ind Health. 2011;27:675-82 pubmed publisher
    ..Known mutagens sodium azide (NaN(3)) and 9-Aminoacridine (9-AA) were used to determine antimutagenic properties of methanol extracts...
  7. Markiewicz J, Wiest O, Helquist P. Synthesis of primary aryl amines through a copper-assisted aromatic substitution reaction with sodium azide. J Org Chem. 2010;75:4887-90 pubmed publisher
    A method is presented by which aryl halides and azides are converted to the corresponding primary aryl amines with copper(I) and sodium azide.
  8. Liu C, Wang S, Deb A, Nath K, Katusic Z, McConnell J, et al. Proapoptotic, antimigratory, antiproliferative, and antiangiogenic effects of commercial C-reactive protein on various human endothelial cell types in vitro: implications of contaminating presence of sodium azide in commercial preparation. Circ Res. 2005;97:135-43 pubmed
    ..The effects of commercial CRP, dialyzed commercial CRP (dCRP) to remove azide, and sodium azide (NaN3) alone at equivalent concentrations to the undialyzed preparation were tested at varying concentrations ..
  9. Ji D, Kamalden T, Del Olmo Aguado S, Osborne N. Light- and sodium azide-induced death of RGC-5 cells in culture occurs via different mechanisms. Apoptosis. 2011;16:425-37 pubmed publisher
    ..the present study was to compare the death mechanism of a light insult to RGC-5 cells in culture with that of sodium azide. Sodium azide's main toxic action is in inhibiting the function of cytochrome oxidase in the mitochondrial ..

More Information

Publications96

  1. van den Berg C, Taylor K, Lang D. C-reactive protein-induced in vitro vasorelaxation is an artefact caused by the presence of sodium azide in commercial preparations. Arterioscler Thromb Vasc Biol. 2004;24:e168-71 pubmed
    ..This study aimed to investigate the mechanism of this CRP-induced response...
  2. Turhan K, Ozturkcan S, Turgut Z, Karadayi M, Gulluce M. Protective properties of five newly synthesized cyclic compounds against sodium azide and N-methyl-N'-nitro-N-nitrosoguanidine genotoxicity. Toxicol Ind Health. 2012;28:605-13 pubmed publisher
    ..determine the antimutagenic potential of five newly synthesized cyclic compounds against the genotoxic agents sodium azide (NaN?) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)...
  3. Garnier P, Ying W, Swanson R. Ischemic preconditioning by caspase cleavage of poly(ADP-ribose) polymerase-1. J Neurosci. 2003;23:7967-73 pubmed
    ..These findings suggest a novel interaction between the caspase- and PARP-1-mediated cell death pathways in which sublethal caspase activation leads to PARP-1 cleavage, thereby increasing resistance to subsequent ischemic stress...
  4. Qamirani E, Razavi H, Wu X, Davis M, Kuo L, Hein T. Sodium azide dilates coronary arterioles via activation of inward rectifier K+ channels and Na+-K+-ATPase. Am J Physiol Heart Circ Physiol. 2006;290:H1617-23 pubmed
    b>Sodium azide (NaN(3)), a potent vasodilator, causes severe hypotension on accidental exposure...
  5. Chang S, Lamm S. Human health effects of sodium azide exposure: a literature review and analysis. Int J Toxicol. 2003;22:175-86 pubmed
    b>Sodium azide, used mainly as a preservative in aqueous laboratory reagents and biologic fluids and as a fuel in automobile airbag gas generants, has caused deaths for decades...
  6. Massie M, Lapoczka E, Boggs K, Stine K, White G. Exposure to the metabolic inhibitor sodium azide induces stress protein expression and thermotolerance in the nematode Caenorhabditis elegans. Cell Stress Chaperones. 2003;8:1-7 pubmed
    Historically, sodium azide has been used to anesthetize the nematode Caenorhabditis elegans; however, the mechanism by which it survives this exposure is not understood...
  7. Ishikawa T, Zhu B, Maeda H. Effect of sodium azide on the metabolic activity of cultured fetal cells. Toxicol Ind Health. 2006;22:337-41 pubmed
    b>Sodium azide is a highly toxic substance. However, the mechanism of its toxicity has not been fully established...
  8. Selvatici R, Previati M, Marino S, Marani L, Falzarano S, Lanzoni I, et al. Sodium azide induced neuronal damage in vitro: evidence for non-apoptotic cell death. Neurochem Res. 2009;34:909-16 pubmed publisher
    ..The mitochondrial dysfunction induced by NaN(3) provides a common platform for investigating the mechanisms of both ischemic and degenerative neuronal injury, useful for screening potential protective agents against neuronal death...
  9. Kume T, Nishikawa H, Taguchi R, Hashino A, Katsuki H, Kaneko S, et al. Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro. Eur J Pharmacol. 2002;455:91-100 pubmed
    ..The induction of chemical ischemia by sodium azide and 2-deoxy-D-glucose led to delayed neuronal death in a time- and concentration-dependent manner, as ..
  10. Dilworth D, Suprapto A, Padovan J, Chait B, Wozniak R, Rout M, et al. Nup2p dynamically associates with the distal regions of the yeast nuclear pore complex. J Cell Biol. 2001;153:1465-78 pubmed
    ..Together, our data support a model in which Nup2p movement facilitates the transition between the import and export phases of nucleocytoplasmic transport...
  11. Sadiq M, Owais W. Mutagenicity of sodium azide and its metabolite azidoalanine in Drosophila melanogaster. Mutat Res. 2000;469:253-7 pubmed
    The mutagenic and toxic activities of sodium azide (NaN(3) ) and its organic metabolite L-azidoalanine [N(3)-CH(2)-CH(NH)(2)-COOH] were examined in the different stages of spermatogenesis in Drosophila melanogaster...
  12. Hansen H, Hansen S, Schousboe A, Hansen H. Determination of the phospholipid precursor of anandamide and other N-acylethanolamine phospholipids before and after sodium azide-induced toxicity in cultured neocortical neurons. J Neurochem. 2000;75:861-71 pubmed
    ..Recently, we have demonstrated that these N-acyl lipids accumulate in cultured neocortical neurons subjected to sodium azide-induced cell injury...
  13. Berndt J, Callaway N, Gonzalez Lima F. Effects of chronic sodium azide on brain and muscle cytochrome oxidase activity: a potential model to investigate environmental contributions to neurodegenerative diseases. J Toxicol Environ Health A. 2001;63:67-77 pubmed
    ..In this study, cytochrome oxidase activity was inhibited following a 28-d systemic administration of nonlethal sodium azide via subcutaneous osmotic pumps...
  14. Torchilin V, Rammohan R, Weissig V, Levchenko T. TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors. Proc Natl Acad Sci U S A. 2001;98:8786-91 pubmed
    ..Low temperature or metabolic inhibitors, sodium azide or iodoacetamide, have little influence on the translocation of TAT liposomes into cells, confirming the energy-..
  15. Shahidullah M, Duncan A, Strachan P, Rafique K, Ball S, McPate M, et al. Role of catalase in the smooth muscle relaxant actions of sodium azide and cyanamide. Eur J Pharmacol. 2002;435:93-101 pubmed
    The aim of this study was to determine the role of catalase in the smooth muscle relaxant actions of sodium azide and cyanamide...
  16. Knyihar Csillik E, Okuno E, Vecsei L. Effects of in vivo sodium azide administration on the immunohistochemical localization of kynurenine aminotransferase in the rat brain. Neuroscience. 1999;94:269-77 pubmed
    ..Accordingly, sodium azide, an inhibitor of cytochrome oxidase, induces the release of excitotoxins via an energy impairment and this, in ..
  17. Zou Y, Gao J, Zhang T, Xu L, Xu J, Lu S. [Changes of thioredoxin mRNA level in neurons with mitochondrial dysfunction insulted by H2O2]. Shi Yan Sheng Wu Xue Bao. 2004;37:15-21 pubmed
    ..b>Sodium azide (NaN3) is a special inhibitor of mitochondrion cytochrome c oxidase (COX), which can be used to mimic neuronal ..
  18. Liu K, Yan S, Wu Y, Yao Z. Synthesis of 4-azido-4-deoxy-Neu5,7,8,9Ac42en1Me. A key intermediate for the synthesis of GG167 from D-glucono-delta-lactone. Org Lett. 2004;6:2269-72 pubmed
    ..A highly diastereoselective allyllation of an imine intermediate, a regioselective azide-opening of an aziridine, and chemoselective oxidations of vicinal diols served successfully as key steps. ..
  19. Gillispie E, Andujar E, Polizzotto M. Chemical controls on abiotic and biotic release of geogenic arsenic from Pleistocene aquifer sediments to groundwater. Environ Sci Process Impacts. 2016;18:1090-103 pubmed publisher
    ..the highest concentrations of dissolved As after >7 months, as compared to sediment samples incubated with sodium azide or without added carbon, and the extent of As release was positively correlated with the percent of initial ..
  20. El Sayed W, Hussin W, Mahmoud A, Alfredan M. The Conyza triloba extracts with high chlorophyll content and free radical scavenging activity had anticancer activity in cell lines. Biomed Res Int. 2013;2013:945638 pubmed publisher
    ..Virtually all extracts exerted a strong (>40% reduction) antimutagenic activity against sodium azide and benzopyrene. Extracts II, III, and IV showed a remarkable growth inhibition profile with GI50 of 0.07-0...
  21. Voitekhovich S, Wolf A, Guhrenz C, Lyakhov A, Ivashkevich L, Adam M, et al. 5-(2-Mercaptoethyl)-1H-tetrazole: Facile Synthesis and Application for the Preparation of Water Soluble Nanocrystals and Their Gels. Chemistry. 2016;22:14746-52 pubmed publisher
    ..This effective synthetic procedure is based on the cycloaddition of sodium azide to 3,3'-dithiobis(propionitrile) followed by the reductive cleavage of a S-S bond with triphenylphosphine...
  22. Shi Q, Chen X, Lu T, Jing X. The immobilization of proteins on biodegradable polymer fibers via click chemistry. Biomaterials. 2008;29:1118-26 pubmed
    ..Therefore, the TSP50-immobilized fibers can be used in the detection, separation, and purification of anti-TSP50. The "click" method can lead to a universal strategy to protein immobilization. ..
  23. Meatherall R, Palatnick W. Convenient headspace gas chromatographic determination of azide in blood and plasma. J Anal Toxicol. 2009;33:525-31 pubmed
    ..concentrations from a 59-year-old man were monitored for 24 h following the ingestion of an unknown amount of sodium azide is presented. The patient became critically ill after his self-inflicted sodium azide ingestion...
  24. Itle L, Pishko M. Multiphenotypic whole-cell sensor for viability screening. Anal Chem. 2005;77:7887-93 pubmed
    ..phenotypes were examined for their response to the addition of two model chemotoxins: sodium hypochlorite and sodium azide, and one model biotoxin, concanavalin A...
  25. Buchan J, Yoon J, Parker R. Stress-specific composition, assembly and kinetics of stress granules in Saccharomyces cerevisiae. J Cell Sci. 2011;124:228-39 pubmed publisher
    ..In the present study, we examine how sodium azide (NaN(3)), which inhibits mitochondrial respiration, affects formation of mRNP granules as compared with glucose ..
  26. Song N, Zheng Y, E S, Li D. Cloning, expression, and characterization of thermostable manganese superoxide dismutase from Thermoascus aurantiacus var. levisporus. J Microbiol. 2009;47:123-30 pubmed publisher
    ..The optimum temperature of the enzyme was 55 degrees C and it exhibited maximal activity at pH 7.5. The enzyme was thermostable at 50 and 60 degrees C and the half-life at 80 degrees C was approximately 40 min...
  27. Suhr M, Kreusch T. Burn injuries resulting from (accidental) airbag inflation. J Craniomaxillofac Surg. 2004;32:35-7 pubmed
    ..They may occasionally perforate, resulting in the release of sodium azide or sodium hydroxide, which result in chemical burns when in contact with skin...
  28. Granieri L, Miller O, Griffiths A, Merten C. A competition-based assay for the screening of species-specific antibiotics. J Antimicrob Chemother. 2009;64:62-8 pubmed publisher
    ..were determined in the presence and absence of the specific antibiotic streptomycin and the toxic compound sodium azide. The results were compared with a standard cfu assay. In the absence of an effective antibiotic, S...
  29. Birkedal R, Gesser H. Regulation of mitochondrial energy production in cardiac cells of rainbow trout (Oncorhynchus mykiss). J Comp Physiol B. 2004;174:255-62 pubmed
    ..Thus, despite difference in structure, temperature and metabolic capacity, trout myocardium resembles that of rat with regard to the regulation of mitochondrial respiration. ..
  30. Wellmann S, Buhrer C, Moderegger E, Zelmer A, Kirschner R, Koehne P, et al. Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism. J Cell Sci. 2004;117:1785-94 pubmed
    ..Thus, RBM3 and CIRP are adaptatively expressed in response to hypoxia by a mechanism that involves neither HIF-1 nor mitochondria. ..
  31. Vernwal S, Yadav R, Yadav K. Purification of a peroxidase from Solanum melongena fruit juice. Indian J Biochem Biophys. 2006;43:239-43 pubmed
    ..5 mM and 0.33 mM, respectively. The pH and temperature optima were 5.5 and 84 degrees C, respectively using guaiacol as the substrate. Sodium azide and phenyl hydrazine inhibited the enzyme competitively.
  32. Kalisiak J, Sharpless K, Fokin V. Efficient synthesis of 2-substituted-1,2,3-triazoles. Org Lett. 2008;10:3171-4 pubmed publisher
    In this three-component reaction, alkynes undergo a copper(I)-catalyzed cycloaddition with sodium azide and formaldehyde to yield 2-hydroxymethyl-2 H-1,2,3-triazoles, which are useful intermediates that can be readily converted to ..
  33. Harmata K, Blackstone N. Reactive oxygen species and the regulation of hyperproliferation in a colonial hydroid. Physiol Biochem Zool. 2011;84:481-93 pubmed publisher
    ..Via uncharacterized pathways, these ROS may contribute to hyperproliferation...
  34. Thorne D, Crooks I, Hollings M, Seymour A, Meredith C, Gaca M. The mutagenic assessment of an electronic-cigarette and reference cigarette smoke using the Ames assay in strains TA98 and TA100. Mutat Res. 2016;812:29-38 pubmed publisher
    ..Positive control responses were observed in both strains, using benzo[a]pyrene, 2-nitrofluorene, sodium azide and 2-aminoanthracene in TA98 and TA100 in the presence and absence of metabolic activation respectively...
  35. Ladeira Ázar R, Morgan T, Dos Santos A, de Aquino Ximenes E, Ladisch M, Guimarães V. Deactivation and activation of lignocellulose degrading enzymes in the presence of laccase. Enzyme Microb Technol. 2018;109:25-30 pubmed publisher
    ..Removal of laccase (enzyme) activity using sodium azide resulted in a 2x higher xylanase deactivation (from 40% to 80%)...
  36. Wu C, Sun X, Feng C, Liu X, Wang H, Feng F, et al. Proton-Coupled Organic Cation Antiporter Contributes to the Hepatic Uptake of Matrine. J Pharm Sci. 2016;105:1301-6 pubmed publisher
    ..The cellular uptake was saturable and was significantly reduced by the metabolic inhibitors, such as sodium azide and rotenone...
  37. Ghidoni R, Gasparini L, Alberici A, Benussi L, Barbiero L, Mazzoli F, et al. Inhibition of energy metabolism down-regulates the Alzheimer related presenilin 2 gene. J Neural Transm (Vienna). 2003;110:1029-39 pubmed
    ..We demonstrated that the inhibition of energy metabolism by sodium azide down-regulates PS2 gene expression through modification of promoter activity...
  38. Lamore S, Azimian S, Horn D, Anglin B, Uchida K, Cabello C, et al. The malondialdehyde-derived fluorophore DHP-lysine is a potent sensitizer of UVA-induced photooxidative stress in human skin cells. J Photochem Photobiol B. 2010;101:251-64 pubmed publisher
    ..Taken together, these data demonstrate photodynamic activity of DHP-lysine and support the hypothesis that malondialdehyde-derived protein-epitopes may function as endogenous sensitizers of UVA-induced oxidative stress in human skin. ..
  39. Park Y, Hahm K. Effects of N- and C-terminal truncation of HP (2-20) from Helicobacter pylori ribosomal protein L1 (RPL1) on its anti-microbial activity. Biotechnol Lett. 2005;27:193-9 pubmed
    ..Flow cytometric analysis, scanning electron microscopy and fluorescence confocal microscopy revealed that HP (4-16) acted rapidly on the plasma membranes of the fungal cells in a salt- and energy-independent manner. ..
  40. Venegas Caleron M, Martínez Force E, Garcés R. Lipid characterization of a wrinkled sunflower mutant. Phytochemistry. 2008;69:684-91 pubmed
  41. Chang T, Liu C, Lin Y, Li C, Wang A, Chien M, et al. Mapping and comparative proteomic analysis of the starch biosynthetic pathway in rice by 2D PAGE/MS. Plant Mol Biol. 2017;95:333-343 pubmed publisher
    ..One pure line rice mutant, SA0419, was induced from a wild-type rice, TNG67, by sodium azide mutagenesis; therefore, TNG67 and SA0419 share the same genetic background...
  42. Mosa K, Kumar K, Chhikara S, Musante C, White J, Dhankher O. Enhanced Boron Tolerance in Plants Mediated by Bidirectional Transport Through Plasma Membrane Intrinsic Proteins. Sci Rep. 2016;6:21640 pubmed publisher
    ..Boron tolerance in OsPIP1;3 and OsPIP2;6 lines was inhibited by aquaporin inhibitors, silver nitrate and sodium azide. Our data proved that OsPIP1;3 and OsPIP2;6 are indeed involved in both influx and efflux of boron transport...
  43. Poladyan A, Trchounian A. The increase in the number of accessible SH-groups in the enterococcal membrane vesicles by ATP and nicotinamide adenine dinucleotides. Curr Microbiol. 2006;52:300-4 pubmed
    ..The change was lacking in the presence of the F0F1-ATPase inhibitors N,N'-diclohexylcarbodiimide or sodium azide. This was also absent in atp mutant with defect in the F0F1-ATPase and, in addition, it was less in potassium ..
  44. Ma T, Boivin M, Ye D, Pedram A, Said H. Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am J Physiol Gastrointest Liver Physiol. 2005;288:G422-30 pubmed
  45. Sung W, Lee D. The candidacidal activity of indole-3-carbinol that binds with DNA. IUBMB Life. 2007;59:408-12 pubmed
    ..The results suggest that I3C may exert anticandidal activity by binding to DNA. The present study indicates that I3C has considerable anticandidal activity, deserving further investigation for clinical applications. ..
  46. Cheng J, Gu Z, He C, Jin J, Wang L, Li G, et al. An efficient synthesis of novel bis-triazole glycoconjugates via a three-component condensation as a key reaction. Carbohydr Res. 2015;414:72-7 pubmed publisher
    ..after utilizing a three-component condensation of propargyl per-O-acetyl-β-d-glycoside, formaldehyde, and sodium azide as a key step to synthesize 2-hydroxymethyl-2H-1,2,3-triazole glycoconjugates...
  47. Liu X, Zhou B, Mi S, Xue L, Shih J, Lee J, et al. An increase of cytochrome C oxidase mediated disruption of gemcitabine incorporation into DNA in a resistant KB clone. Biochem Pharmacol. 2007;73:1927-38 pubmed
    ..Furthermore, the sensitivity to Gem could be reversed by sodium azide, a CCOX inhibitor...
  48. Imai T, Mihara H, Kurihara T, Esaki N. Selenocysteine is selectively taken up by red blood cells. Biosci Biotechnol Biochem. 2009;73:2746-8 pubmed
    ..We found that selenocysteine was taken up into red blood cells without decomposition into selenide. ..
  49. Kusche Vihrog K, Urbanova K, Blanqué A, Wilhelmi M, Schillers H, Kliche K, et al. C-reactive protein makes human endothelium stiff and tight. Hypertension. 2011;57:231-7 pubmed publisher
    ..The data indicate that CRP enhances the effects of aldosterone on the mechanical properties of the endothelium. Thus, CRP could counteract any decrease in arterial blood pressure that accompanies severe acute inflammatory processes. ..
  50. Kumar D, Reddy V, Kumar A, Mandal D, Tiwari R, Parang K. Click chemistry inspired one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles and their Src kinase inhibitory activity. Bioorg Med Chem Lett. 2011;21:449-52 pubmed publisher
    ..1,4-disubstituted 1,2,3-triazoles were synthesized using one-pot reaction of ?-tosyloxy ketones/?-halo ketones, sodium azide, and terminal alkynes in the presence of aq PEG (1:1, v/v) using the click chemistry approach and evaluated for ..
  51. Funadani R, Suetomo Y, Matsuoka T. Emergence of the terrestrial ciliate Colpoda cucullus from a resting cyst: rupture of the cyst wall by active expansion of an excystment vacuole. Microbes Environ. 2013;28:149-52 pubmed
    ..In hypotonic medium containing sodium azide (NaN3, a cytochrome c oxidase inhibitor), the contractile vacuole of vegetative cells stopped pulsating and ..
  52. Bourke E, Cassetti A, Villa A, Fadlon E, Colotta F, Mantovani A. IL-1 beta scavenging by the type II IL-1 decoy receptor in human neutrophils. J Immunol. 2003;170:5999-6005 pubmed
    ..These results suggest that the decoy receptor IL-1RII can act as a scavenger of IL-1, representing a novel autoregulatory mechanism of the IL-1 system...
  53. Zaitsu K, Miki A, Katagi M, Tsuchihashi H. Long-term stability of various drugs and metabolites in urine, and preventive measures against their decomposition with special attention to filtration sterilization. Forensic Sci Int. 2008;174:189-96 pubmed
    ..The kit was also effective in preventing the hydrolyses of COC and 6AM, while it was suggested that the common preservative NaN(3) can accelerate the hydrolysis of such ester-type drugs and metabolites...
  54. Pang Q, Zhang S, Shi X, Su F, Wu D. Purification and characterisation of phenoloxidase from amphioxus Branchiostoma belcheri tsingtauense. Fish Shellfish Immunol. 2005;19:139-48 pubmed
  55. Keshavarz M, Badri R. A facile and one pot synthesis of 1,4-disubstituted-1H-1,2,3-triazoles from terminal alkynes and phenacyl azides prepared from styrenes by CAN oxidant and sodium azide. Mol Divers. 2011;15:957-62 pubmed publisher
    ..The corresponding ?-azido ketones were directly prepared in situ from various substituted styrenes using the oxidant cerium ammonium nitrate and sodium azide in oxygen-saturated methanol.
  56. Moir D, Di M, Wong E, Moore R, Schweizer H, Woods D, et al. Development and application of a cellular, gain-of-signal, bioluminescent reporter screen for inhibitors of type II secretion in Pseudomonas aeruginosa and Burkholderia pseudomallei. J Biomol Screen. 2011;16:694-705 pubmed publisher
    ..In addition, seven of the nine compounds also inhibited the T2S-mediated extracellular secretion of phospholipase C by P. aeruginosa and protease activity by Burkholderia pseudomallei...
  57. Hargrove M. Ligand binding with stopped-flow rapid mixing. Methods Mol Biol. 2005;305:323-42 pubmed
    ..Simple experiments for measuring reaction dead time and flushing volume are also described along with the details of several common reaction schemes and methods for data analysis...
  58. Fernández Teruel C, Gonzalez Alvarez I, Casabo V, Ruiz Garcia A, Bermejo M. Kinetic modelling of the intestinal transport of sarafloxacin. Studies in situ in rat and in vitro in Caco-2 cells. J Drug Target. 2005;13:199-212 pubmed
    ..The transport system in the rat model was ATP-dependent, as sodium azide was able to decrease the absorption rate constant in a concentration-dependent fashion...
  59. Bernard B, Nakamura Y, Aihara K, Mennear J. Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): IX. Evaluation of the mutagenic potential of synthesized L-valyl-L-prolyl-L-proline in the Salmonella-Escherichia coli/microsome, i. Int J Toxicol. 2005;24 Suppl 4:107-13 pubmed
    ..Positive-control agents included sodium azide (TA100 and TA1535); 2-aminoanthracene (TA98, TA100, TA1535, TA1537, and WP2uvrA); 9-aminoacridine (TA1537); 2-..
  60. Lang L, Li B, Liu W, Jiang L, Xu Z, Yin G. Mesoporous ZnS nanospheres: a high activity heterogeneous catalyst for synthesis of 5-substituted 1H-tetrazoles from nitriles and sodium azide. Chem Commun (Camb). 2010;46:448-50 pubmed publisher
    Mesoporous ZnS nanospheres is a novel heterogeneous catalyst for synthesis of 5-substituted 1H-tetrazoles from various nitriles and sodium azide with excellent catalytic performance.
  61. Tong P, Hong Y, Xiao Y, Zhang M, Tu X, Cui T. High production of laccase by a new basidiomycete, Trametes sp. Biotechnol Lett. 2007;29:295-301 pubmed
    ..LacE at 0.5 U l(-1) could decolorize industrial dyes. The open reading frame of the lacE gene was 2,130 bp and was interrupted by 10 introns. It displayed a high homology to laccases from other fungi...
  62. Liu K, Samuel M, Tillett J, Hennan J, Mekonnen B, Soloveva V, et al. High-throughput screening for Kv1.3 channel blockers using an improved FLIPR-based membrane-potential assay. J Biomol Screen. 2010;15:185-95 pubmed publisher
    ..Some compounds possess nanomolar potency, indicating that the FLIPR assay is effective for successfully identifying K(+) channel blockers as novel drug candidates...
  63. Shojania S, O Neil J. HIV-1 Tat is a natively unfolded protein: the solution conformation and dynamics of reduced HIV-1 Tat-(1-72) by NMR spectroscopy. J Biol Chem. 2006;281:8347-56 pubmed
    ..The absence of a fixed conformation and the observation of fast dynamics are consistent with the ability of Tat protein to interact with a wide variety of proteins and nucleic acid and support the concept of a natively unfolded protein...
  64. Boyadzhieva I, Atanasova M, Emanuilova E. A novel, thermostable manganese-containing superoxide dismutase from Bacillus licheniformis. Biotechnol Lett. 2010;32:1893-6 pubmed publisher
    ..5 kDa each. The SOD was inhibited only by NaN(3), which suggested that this SOD is of the manganese superoxide dismutase type. The purified enzyme had maximum activity at pH 8 and 55°C. The half-life of the SOD was 10 min at 95°C...
  65. Tse K, Kingham P, Novikov L, Wiberg M. Adipose tissue and bone marrow-derived stem cells react similarly in an ischaemia-like microenvironment. J Tissue Eng Regen Med. 2012;6:473-85 pubmed publisher
    ..This study investigated the effects of ischaemia (metabolically induced by sodium azide and 2-deoxyglucose) and serum-derived mitogens on the viability and functional profile of MSCs in vitro...
  66. Ramachandran S, Fontanille P, Pandey A, Larroche C. Permeabilization and inhibition of the germination of spores of Aspergillus niger for gluconic acid production from glucose. Bioresour Technol. 2008;99:4559-65 pubmed
    In this study, the role of citral to permeabilize the spores of Aspergillus niger and replace sodium azide in the bioconversion medium was studied...
  67. Tran T, Kim D, Ko S. Synergistic effects of biogenic manganese oxide and Mn(II)-oxidizing bacterium Pseudomonas putida strain MnB1 on the degradation of 17 ?-ethinylestradiol. J Hazard Mater. 2018;344:350-359 pubmed publisher
    ..Also, sharp decreases in EE2 removal were observed when microbial activity was inactivated by heat treatment or sodium azide. From this study, the EE2 removal mechanisms by BMO in the presence P...
  68. Nishida C, Ogawara K, Kimura T, Higaki K. Pharmacokinetic analysis of factors determining elimination pathways for sulfate and glucuronide metabolites of xenobiotics. III: mechanisms for sinusoidal efflux of 4-methylumbelliferone sulfate. Xenobiotica. 2004;34:439-48 pubmed
    ..2. The effect of sodium azide on the hepatic handling of both conjugates was examined...
  69. Dauletbaev N, Rickmann J, Viel K, Diegel H, von Mallinckrodt C, Stein J, et al. Antioxidant properties of cystic fibrosis sputum. Am J Physiol Lung Cell Mol Physiol. 2005;288:L903-9 pubmed
    ..potential of CF sputum was sustained after catalase and heme peroxidases were inactivated by sodium azide, which does not affect glutathione peroxidase...
  70. Agarkova I, Dunigan D, Gurnon J, Greiner T, Barres J, Thiel G, et al. Chlorovirus-mediated membrane depolarization of Chlorella alters secondary active transport of solutes. J Virol. 2008;82:12181-90 pubmed publisher
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    ..The mechanisms underlying DNA damage induced by incense emissions were also investigated. Catalase (CAT), sodium azide, and superoxide dismutase (SOD) were co-incubated with extract, which exerted significant DNA damaging effects...
  72. Mahad D, Ziabreva I, Campbell G, Lax N, White K, Hanson P, et al. Mitochondrial changes within axons in multiple sclerosis. Brain. 2009;132:1161-74 pubmed publisher
    ..Our findings have important implications for both axonal degeneration and dysfunction during the progressive stage of multiple sclerosis. ..
  73. Roy S, Mason B, Schöneich C, Carpenter J, Boone T, Kerwin B. Light-induced aggregation of type I soluble tumor necrosis factor receptor. J Pharm Sci. 2009;98:3182-99 pubmed publisher
    ..To our knowledge this is the first report directly documenting disulfide mediated aggregation through thiyl radical formation initiated by photoirradiation of Trp...
  74. Shrestha K, Liu S, Huang C, Wu H, Wang W, Li Y. Characterization and identification of essential residues of the glycoside hydrolase family 64 laminaripentaose-producing-?-1, 3-glucanase. Protein Eng Des Sel. 2011;24:617-25 pubmed publisher
    ..Further investigation with chemical rescue using sodium azide on E154G and D174G confirmed that Glu(154) functions as the general acid whereas Asp(170) serves as the general ..
  75. Yildirim T, Tasdemir T, Orucoglu H. The evaluation of the influence of using MTA in teeth with post indication on the apical sealing ability. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:471-4 pubmed publisher
  76. Chaal B, Green B. Protein import pathways in 'complex' chloroplasts derived from secondary endosymbiosis involving a red algal ancestor. Plant Mol Biol. 2005;57:333-42 pubmed
  77. Claffey J, Deally A, Gleeson B, Hogan M, Méndez L, Müller Bunz H, et al. Pseudo-halide derivatives of titanocene: synthesis and cytotoxicity studies. Metallomics. 2009;1:511-7 pubmed publisher
    ..drug candidate bis-[(p-methoxybenzyl)cyclopentadienyl] titanium(IV) dichloride (Titanocene ) was reacted with sodium azide or potassium cyanate, thiocyanate or selenocyanate in order to give pseudo-halide analogues of Titanocene ...
  78. Beckner M, Gobbel G, Abounader R, Burovic F, Agostino N, Laterra J, et al. Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis. Lab Invest. 2005;85:1457-70 pubmed
    ..in migration), and Matrigel invasion of U87 and LN229 glioma cells when their mitochondria were inhibited with sodium azide or limited by 1% O(2)...
  79. Kim K, Cho H, Lee S, Ahn J, Cheon H. Neuroprotective effects of KR-62980, a new PPAR? agonist, against chemical ischemia-reperfusion in SK-N-SH cells. Brain Res. 2011;1372:103-14 pubmed publisher
  80. Zbikowska H, Nowak P, Wachowicz B. Protein modification caused by a high dose of gamma irradiation in cryo-sterilized plasma: protective effects of ascorbate. Free Radic Biol Med. 2006;40:536-42 pubmed
    ..the yield of which was dramatically decreased when plasma was irradiated in the presence of either sodium azide or ascorbate...
  81. Kung F, Tsai J, Lee C, Lou K, Tang C, Liou H, et al. Effects of sodium azide, barium ion, d-amphetamine and procaine on inward rectifying potassium channel 6.2 expressed in Xenopus oocytes. J Formos Med Assoc. 2008;107:600-8 pubmed publisher
    ..2 (Kir6.2DelataC26 channel) is closely related to ATP-sensitive potassium channels. Whether sodium azide, barium ion, d-amphetamine or procaine acts directly on the Kir6.2DeltaC26 channel remains unclear...
  82. Borghini A, Crotti P, Pietra D, Favero L, Bianucci A. Chemical reactivity predictions: use of data mining techniques for analyzing regioselective azidolysis of epoxides. J Comput Chem. 2010;31:2612-9 pubmed publisher
    ..The models so obtained are able to predict the regioselectivity of the azidolysis of epoxides promoted by sodium azide, in the presence of lithium perchlorate, on the basis of steric hindrance, and charge distribution of the ..
  83. Ensafi A, Rahimi Mansour H, Majlesi R. Determination of trace amount of carbon disulfide in water by the spectrophotometric reaction-rate method. Anal Sci. 2003;19:1679-81 pubmed
    ..870 microg/ml CS2. The limit of detection is 0.013 microg/ml CS2. A carbon-active column was used for sample solution clean up. The proposed method was successfully applied to the determination of trace carbon disulfide in natural water...
  84. Okawara M, Katsuki H, Kurimoto E, Shibata H, Kume T, Akaike A. Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults. Biochem Pharmacol. 2007;73:550-60 pubmed
    ..Resveratrol also provided concentration-dependent neuroprotective effects against sodium azide, a mitochondrial complex IV inhibitor, and thrombin (EC number 3.4.21.5), a microglia-activating agent...
  85. Harmon A, Williams Z, Holler L, Hildreth M. Comparison of three different preservatives for morphological and real-time PCR analyses of Haemonchus contortus eggs. Vet Parasitol. 2007;145:361-5 pubmed
    ..In this study, Lugol's iodine (LI), sodium azide (SA), and neutral buffered formalin (NBF) were evaluated using Haemonchus contortus eggs to determine their ..
  86. Furukawa A, Oikawa S, Harada K, Sugiyama H, Hiraku Y, Murata M, et al. Oxidatively generated DNA damage induced by 3-amino-5-mercapto-1,2,4-triazole, a metabolite of carcinogenic amitrole. Mutat Res. 2010;694:7-12 pubmed publisher
    ..b>Sodium azide and 1,4-diazabicyclo[2,2,2]-octane (DABCO), potent and relatively specific scavengers of ¹O?, inhibited AMT-..
  87. Betterton E, Lowry J, Ingamells R, Venner B. Kinetics and mechanism of the reaction of sodium azide with hypochlorite in aqueous solution. J Hazard Mater. 2010;182:716-22 pubmed publisher
    Production of toxic sodium azide (NaN(3)) surged worldwide over the past two decades to meet the demand for automobile air bag inflator propellant...