crocidolite asbestos

Summary

Summary: A lavender, acid-resistant asbestos.

Top Publications

  1. Kurumatani N, Kumagai S. Mapping the risk of mesothelioma due to neighborhood asbestos exposure. Am J Respir Crit Care Med. 2008;178:624-9 pubmed publisher
    ..Little is known about neighborhood exposure to asbestos and mesothelioma risk among residents around an industrial source of asbestos...
  2. Faux S, Howden P. Possible role of lipid peroxidation in the induction of NF-kappa B and AP-1 in RFL-6 cells by crocidolite asbestos: evidence following protection by vitamin E. Environ Health Perspect. 1997;105 Suppl 5:1127-30 pubmed
    ..These studies were designed to determine if crocidolite asbestos-induced lipid peroxidation plays a role in the mechanism of formation of NF-kappa B and AP-1...
  3. Hansen J, de Klerk N, Musk A, Hobbs M. Environmental exposure to crocidolite and mesothelioma: exposure-response relationships. Am J Respir Crit Care Med. 1998;157:69-75 pubmed
    ..The rate increased significantly with time from first exposure, duration of exposure and cumulative exposure. At these levels of crocidolite exposure, there is a significantly increased risk of mesothelioma, which is dose-dependent...
  4. Perkins R, Broaddus V, Shetty S, Hamilton S, Idell S. Asbestos upregulates expression of the urokinase-type plasminogen activator receptor on mesothelial cells. Am J Respir Cell Mol Biol. 1999;21:637-46 pubmed
    ..uPAR expression was induced by chrysotile and crocidolite asbestos, but not by wollastonite, as indicated by binding of radiolabeled urokinase-type plasminogen activator (uPA)..
  5. Riganti C, Aldieri E, Bergandi L, Fenoglio I, Costamagna C, Fubini B, et al. Crocidolite asbestos inhibits pentose phosphate oxidative pathway and glucose 6-phosphate dehydrogenase activity in human lung epithelial cells. Free Radic Biol Med. 2002;32:938-49 pubmed
    ..We propose here a new mechanism of asbestos-evoked oxidative stress, wherein fibers increase the intracellular ROS levels also by inhibiting the main antioxidant pathway of the cell...
  6. Yuan Z, Taatjes D, Mossman B, Heintz N. The duration of nuclear extracellular signal-regulated kinase 1 and 2 signaling during cell cycle reentry distinguishes proliferation from apoptosis in response to asbestos. Cancer Res. 2004;64:6530-6 pubmed
    ..reentry, we show that the duration of phospho-ERK1/2 in the nucleus determines cell fate in response to crocidolite asbestos. In response to 10% serum, a proliferative stimulus, phosphorylated ERK1/2 initially accumulated in the ..
  7. Nygren J, Suhonen S, Norppa H, Linnainmaa K. DNA damage in bronchial epithelial and mesothelial cells with and without associated crocidolite asbestos fibers. Environ Mol Mutagen. 2004;44:477-82 pubmed
    ..induction of DNA damage in human bronchial epithelial BEAS 2B cells and human mesothelial MeT 5A cells by crocidolite asbestos (2 microg/cm2) requires the presence of asbestos fibers in the cells...
  8. Alfonso H, Fritschi L, de Klerk N, Olsen N, Sleith J, Musk A. Effects of asbestos and smoking on the levels and rates of change of lung function in a crocidolite exposed cohort in Western Australia. Thorax. 2004;59:1052-6 pubmed
    ..Exposure to asbestos is associated with reduced static lung volumes, gas transfer and lung compliance, and a restrictive ventilatory abnormality...
  9. Alfonso H, Fritschi L, de Klerk N, Ambrosini G, Beilby J, Olsen N, et al. Plasma concentrations of retinol, carotene, and vitamin E and mortality in subjects with asbestosis in a cohort exposed to crocidolite in Wittenoom, Western Australia. J Occup Environ Med. 2005;47:573-9 pubmed
    ..We sought to examine the relationships between plasma concentrations of retinol, carotene, and vitamin E and mortality associated with asbestosis in people previously exposed to crocidolite...

More Information

Publications101 found, 100 shown here

  1. Kroczynska B, Cutrone R, Bocchetta M, Yang H, Elmishad A, Vacek P, et al. Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters. Proc Natl Acad Sci U S A. 2006;103:14128-33 pubmed
    ..Our results indicate that mineral fibers and viruses can be cocarcinogens and suggest that lower amounts of asbestos may be sufficient to cause MM in individuals infected with SV40...
  2. Blake D, Bolin C, Cox D, Cardozo Pelaez F, Pfau J. Internalization of Libby amphibole asbestos and induction of oxidative stress in murine macrophages. Toxicol Sci. 2007;99:277-88 pubmed
    ..of Libby amphibole exposure in macrophages compared to another well-characterized amphibole fiber; crocidolite asbestos. Our results indicate that Libby asbestos fibers are internalized by macrophages and localize to the ..
  3. Griffith D, Miller E, Gray L, Idell S, Johnson A. Interleukin-1-mediated release of interleukin-8 by asbestos-stimulated human pleural mesothelial cells. Am J Respir Cell Mol Biol. 1994;10:245-52 pubmed
    ..Suspensions of amosite, chrysotile, or crocidolite asbestos in concentrations as low as 5 micrograms/ml enhanced release of IL-8 from HPMC during 6 h of incubation at ..
  4. Johnson N, Jaramillo R. p53, Cip1, and Gadd153 expression following treatment of A549 cells with natural and man-made vitreous fibers. Environ Health Perspect. 1997;105 Suppl 5:1143-5 pubmed
    ..The clear difference in response between crocidolite and JM 100 may help elucidate the mechanism of action of toxic and nontoxic fibers...
  5. Lang D, Schocker H, Hockertz S. Effects of crocidolite asbestos on human bronchoepithelial-dependent fibroblast stimulation in coculture: the role of IL-6 and GM-CSF. Toxicology. 2001;159:81-98 pubmed
    ..For this purpose, epithelial cells were pre-exposed to UICC crocidolite asbestos fibers or titanium dioxide (TiO2) particles for 96 h and subsequently cocultured with fibroblasts for ..
  6. Xu A, Zhou H, Yu D, Hei T. Mechanisms of the genotoxicity of crocidolite asbestos in mammalian cells: implication from mutation patterns induced by reactive oxygen species. Environ Health Perspect. 2002;110:1003-8 pubmed
    ..These results provide direct evidence that the mutagenicity of asbestos is mediated by ROS in mammalian cells...
  7. Ramos Nino M, Scapoli L, Martinelli M, Land S, Mossman B. Microarray analysis and RNA silencing link fra-1 to cd44 and c-met expression in mesothelioma. Cancer Res. 2003;63:3539-45 pubmed
    ..microarray analysis (Affymetrix array) of normal rat pleural mesothelial (RPM) cells, RPM cells exposed to crocidolite asbestos, and rat mesotheliomas, subsets of genes that changed in expression were categorized, including the highly ..
  8. Pande P, Mosleh T, Aust A. Role of alphavbeta5 integrin receptor in endocytosis of crocidolite and its effect on intracellular glutathione levels in human lung epithelial (A549) cells. Toxicol Appl Pharmacol. 2006;210:70-7 pubmed
    ..Thus, we observed that endocytosis of crocidolite fibers via integrin alphavbeta5 receptor is linked to the marked decrease in total intracellular glutathione in A549 cells...
  9. Baldys A, Pande P, Mosleh T, Park S, Aust A. Apoptosis induced by crocidolite asbestos in human lung epithelial cells involves inactivation of Akt and MAPK pathways. Apoptosis. 2007;12:433-47 pubmed
    ..Here, we report that exposure of A549 cells to crocidolite asbestos led to a significant time-dependent inactivation of signaling proteins, i.e...
  10. Nymark P, Lindholm P, Korpela M, Lahti L, Ruosaari S, Kaski S, et al. Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines. BMC Genomics. 2007;8:62 pubmed
    ..We exposed the human cell lines A549, Beas-2B and Met5A to crocidolite asbestos and determined time-dependent gene expression profiles by using Affymetrix arrays...
  11. Shukla A, Macpherson M, Hillegass J, Ramos Nino M, Alexeeva V, Vacek P, et al. Alterations in gene expression in human mesothelial cells correlate with mineral pathogenicity. Am J Respir Cell Mol Biol. 2009;41:114-23 pubmed publisher
    ..were exposed to low and high (15 and 75 microm(2)/cm(2) dish) equal surface area concentrations of crocidolite asbestos, nonfibrous talc, fine titanium dioxide (TiO2), or glass beads for 8 or 24 hours...
  12. Marsella J, Liu B, Vaslet C, Kane A. Susceptibility of p53-deficient mice to induction of mesothelioma by crocidolite asbestos fibers. Environ Health Perspect. 1997;105 Suppl 5:1069-72 pubmed
    ..acquired a point mutation in the p53 gene shows increased sensitivity to DNA damage induced by crocidolite asbestos fibers...
  13. Kielkowski D, Nelson G, Rees D. Risk of mesothelioma from exposure to crocidolite asbestos: a 1995 update of a South African mortality study. Occup Environ Med. 2000;57:563-7 pubmed
    ..To find the risk of developing mesothelioma in a cohort born in 1916-36 in Prieska, Northern Cape Province, South Africa...
  14. Unfried K, Schürkes C, Abel J. Distinct spectrum of mutations induced by crocidolite asbestos: clue for 8-hydroxydeoxyguanosine-dependent mutagenesis in vivo. Cancer Res. 2002;62:99-104 pubmed
    ..The mutagenic effect of 2 and 5 mg of crocidolite asbestos was demonstrated, with a maximal relative increase in mutation frequency of 3...
  15. Hevel J, Olson Buelow L, Ganesan B, Stevens J, Hardman J, Aust A. Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions. BMC Genomics. 2008;9:376 pubmed publisher
    ..The objective of this study was to generate a comprehensive view of the transcriptional changes induced by crocidolite asbestos in A549 human lung epithelial cells.
  16. Broaddus V, Yang L, Scavo L, Ernst J, Boylan A. Crocidolite asbestos induces apoptosis of pleural mesothelial cells: role of reactive oxygen species and poly(ADP-ribosyl) polymerase. Environ Health Perspect. 1997;105 Suppl 5:1147-52 pubmed
    ..Rabbit pleural mesothelial cells were exposed to crocidolite asbestos or control particles (1-10 micrograms/cm2) over 24 hr and evaluated for oligonucleosomal DNA fragmentation, ..
  17. Lohani M, Dopp E, Becker H, Seth K, Schiffmann D, Rahman Q. Smoking enhances asbestos-induced genotoxicity, relative involvement of chromosome 1: a study using multicolor FISH with tandem labeling. Toxicol Lett. 2002;136:55-63 pubmed
    ..Further the study suggested that smoking makes genetic system of the cells more vulnerable to the deleterious effects of asbestos. ..
  18. Reid A, de Klerk N, Ambrosini G, Berry G, Musk A. The risk of lung cancer with increasing time since ceasing exposure to asbestos and quitting smoking. Occup Environ Med. 2006;63:509-12 pubmed
  19. van den Brule S, Beckers E, Chaurand P, Liu W, Ibouraadaten S, Palmai Pallag M, et al. Nanometer-long Ge-imogolite nanotubes cause sustained lung inflammation and fibrosis in rats. Part Fibre Toxicol. 2014;11:67 pubmed publisher
    ..Our data also suggest that Ge-imogolite structure and external surface determine their toxic activity. ..
  20. Adamis Z, Kerenyi T, Honma K, Jackel M, Tatrai E, Ungvary G. Study of inflammatory responses to crocidolite and basalt wool in the rat lung. J Toxicol Environ Health A. 2001;62:409-15 pubmed
    ..In spite of this, basalt wool is recoinmended as an asbestos substitute, as the use of this man-nade fiber may result in a significantly lower release of dust than that from crocidolite. ..
  21. Poser I, Rahman Q, Lohani M, Yadav S, Becker H, Weiss D, et al. Modulation of genotoxic effects in asbestos-exposed primary human mesothelial cells by radical scavengers, metal chelators and a glutathione precursor. Mutat Res. 2004;559:19-27 pubmed
    ..Also, the iron content of the fiber plays an important role in radical formation, but nevertheless, chrysotile produces oxy radicals to a similar extent as crocidolite, probably by phagocytosis-mediated oxidative bursting...
  22. Carbone M, Rdzanek M. Pathogenesis of malignant mesothelioma. Clin Lung Cancer. 2004;5 Suppl 2:S46-50 pubmed
    ..However, the causal role of chrysotile asbestos compared with crocidolite asbestos in MM, the method of correctly establishing asbestos exposure, the amount of asbestos necessary to cause MM,..
  23. Tan R, Fattman C, Niehouse L, Tobolewski J, Hanford L, Li Q, et al. Matrix metalloproteinases promote inflammation and fibrosis in asbestos-induced lung injury in mice. Am J Respir Cell Mol Biol. 2006;35:289-97 pubmed
    ..Wild-type C57BL/6 mice were intratracheally instilled with 0.1 mg crocidolite asbestos, causing an inflammatory response at 1 d and a developing fibrotic response at 7, 14, and 28 d...
  24. Fleury Feith J, Lecomte C, Renier A, Matrat M, Kheuang L, Abramowski V, et al. Hemizygosity of Nf2 is associated with increased susceptibility to asbestos-induced peritoneal tumours. Oncogene. 2003;22:3799-805 pubmed
  25. Paoletti L, Puledda S. [An approach to the classification and assessment of asbestos-containing wastes: description of a survey conducted in an industrial area]. Med Lav. 1992;83:371-80 pubmed
    ..A general approach to the solution of these issues is offered and applied to the case in question as a possible practical model of environmental control in this specific field. ..
  26. Bergamini C, Fato R, Biagini G, Pugnaloni A, Giantomassi F, Foresti E, et al. Mitochondrial changes induced by natural and synthetic asbestos fibers: studies on isolated mitochondria. Cell Mol Biol (Noisy-le-grand). 2004;50 Online Pub:OL691-700 pubmed
    ..Nevertheless, all asbestos fibers tested induce morphological alterations visualized by transmission electron microscopy and morphometric analysis. ..
  27. Wali A, Morin P, Hough C, Lonardo F, Seya T, Carbone M, et al. Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE). Lung Cancer. 2005;48:19-29 pubmed
    ..in intelectin gene expression was observed among human primary mesothelial cells as a consequence of crocidolite asbestos exposure and simian virus 40 infection...
  28. Nagatomo H, Morimoto Y, Oyabu T, Hirohashi M, Ogami A, Yamato H, et al. Expression of heme oxygenase-1 in the lungs of rats exposed to crocidolite asbestos. Inhal Toxicol. 2005;17:293-6 pubmed
    ..This study was conducted to investigate the time course of HO-1 expression of lungs exposed to crocidolite asbestos in vivo...
  29. Xu A, Huang X, Lien Y, Bao L, Yu Z, Hei T. Genotoxic mechanisms of asbestos fibers: role of extranuclear targets. Chem Res Toxicol. 2007;20:724-33 pubmed
    ..Treatment of enucleated cells with crocidolite asbestos followed by rescue fusion using karyoplasts from control cells resulted in significant mutant induction, ..
  30. Nayebzadeh A, Dufresne A, Case B, Vali H, Williams Jones A, Martin R, et al. Lung mineral fibers of former miners and millers from Thetford-Mines and asbestos regions: a comparative study of fiber concentration and dimension. Arch Environ Health. 2001;56:65-76 pubmed
    ..Among the mineral fibers studied, retention of tremolite fibers was most apparent...
  31. Cardile V, Renis M, Scifo C, Lombardo L, Gulino R, Mancari B, et al. Behaviour of the new asbestos amphibole fluor-edenite in different lung cell systems. Int J Biochem Cell Biol. 2004;36:849-60 pubmed
    ..In conclusion, according to our data, fluoro-edenite appears as a probable carcinogenic agent, responsible for the high incidence of malignant pleural mesothelioma in Biancavilla. ..
  32. Adachi S, Kawamura K, Kimura K, Takemoto K. Tumor incidence was not related to the thickness of visceral pleural in female Syrian hamsters intratracheally administered amphibole asbestos or manmade fibers. Environ Res. 1992;58:55-65 pubmed
  33. Hippeli S, Dornisch K, Wiethege T, Gillissen A, Muller K, Elstner E. Biological durability and oxidative potential of man-made vitreous fibres as compared to crocidolite asbestos fibres. Z Naturforsch C. 2001;56:633-48 pubmed
    In this study we investigated relationships between redox properties and biodurability of crocidolite asbestos fibres and three different man-made vitreous fibres (MMVF): traditional stone wool fibres (MMVF 21), glass fibres (MMVF 11) and ..
  34. Cummins A, Palmer C, Mossman B, Taatjes D. Persistent localization of activated extracellular signal-regulated kinases (ERK1/2) is epithelial cell-specific in an inhalation model of asbestosis. Am J Pathol. 2003;162:713-20 pubmed
    ..C57/BL6 mice were exposed to 7-mg/m(3) air of crocidolite asbestos for 5 and 30 days, the times required for the development of epithelial cell hyperplasia and fibrotic ..
  35. Shen Z, Parker V, Aust A. Mediated, thin-layer cell, coulometric determination of redox-active iron on the surface of asbestos fibers. Anal Chem. 1995;67:307-11 pubmed
    ..The method may be applied to other types of solid materials with redox-active species on their surfaces. ..
  36. Fedi A, Blagini B, Melosi A, Marzuoli E, Ancillotti M, Gorini G, et al. [Assessment of asbestos exposure, mortality study, and health intervention in workers formerly exposed to asbestos in a small factory making drying machines for textile finishing and the paper mill industry in Pistoia, Italy]. Med Lav. 2005;96:243-9 pubmed
    ..Further investigation is needed in order to identify unknown asbestos exposures in small metal engineering factories. ..
  37. Bergamini C, Fato R, Biagini G, Pugnaloni A, Giantomassi F, Foresti E, et al. Mitochondrial changes induced by natural and synthetic asbestos fibers: studies on isolated mitochondria. Cell Mol Biol (Noisy-le-grand). 2007;52 Suppl:OL905-13 pubmed
    ..Nevertheless, all asbestos fibers tested induce morphological alterations visualized by transmission electron microscopy and morphometric analysis. ..
  38. Nakayama T, Yamagami T, Kagamimori S. [Studies on carcinogenicity of asbestos with special reference to interaction between viruses and cultured cells]. Sangyo Eiseigaku Zasshi. 1998;40:195-203 pubmed
    ..All asbestos samples mediated viral RNA transfection compared with the background including only viral RNA. The transfection was much greater with combined exposure to asbestos and kaolin than with exposure to asbestos alone...
  39. Takahashi K, Case B, Dufresne A, Fraser R, Higashi T, Siemiatycki J. Relation between lung asbestos fibre burden and exposure indices based on job history. Occup Environ Med. 1994;51:461-9 pubmed
    ..Smoking, whether expressed in ever or never smoked dichotomy or in smoked-years, had no relation to lung asbestos content in this model. ..
  40. Langer A, Nolan R. Asbestos in the lungs of persons exposed in the USA. Monaldi Arch Chest Dis. 1998;53:168-80 pubmed
  41. Ollikainen T, Linnainmaa K, Kinnula V. DNA single strand breaks induced by asbestos fibers in human pleural mesothelial cells in vitro. Environ Mol Mutagen. 1999;33:153-60 pubmed
    ..Since the inhibition of antioxidant enzymes did not have an effect on the DNA damage caused by the fibers, other mechanisms than free radicals seem to be involved in the induction of DNA damage by mineral fibers. ..
  42. Altomare D, Vaslet C, Skele K, De Rienzo A, Devarajan K, Jhanwar S, et al. A mouse model recapitulating molecular features of human mesothelioma. Cancer Res. 2005;65:8090-5 pubmed
  43. Jiang L, Nagai H, Ohara H, Hara S, Tachibana M, Hirano S, et al. Characteristics and modifying factors of asbestos-induced oxidative DNA damage. Cancer Sci. 2008;99:2142-51 pubmed publisher
  44. Merler E, Chellini E. [Epidemiology of primary tumors of the pleura]. Ann Ist Super Sanita. 1992;28:133-46 pubmed
    ..The authors present the results of both cohort and case-control analytical studies performed in Italy, and provide suggestions for further research. ..
  45. Rogers A, Major G. The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure: the Wittenoom data. Ann Occup Hyg. 2002;46:127-8; author reply 128-9 pubmed
  46. Dong F, Luo S. [Spectra study on the varied features of crocidolite fibers in rat]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2004;35:83-6 pubmed
    ..The residual substances of crocidolite are mainly Si-O. Tissue membrane is the retardation cingulum of dust transference in vivo. ..
  47. Reid A, Heyworth J, de Klerk N, Musk A. Asbestos exposure and gestational trophoblastic disease: a hypothesis. Cancer Epidemiol Biomarkers Prev. 2009;18:2895-8 pubmed publisher
    ..Taking an occupational and residential history and examining pathologic specimens for asbestos fibers or bodies may prove useful in patients with gestational trophoblastic disease. ..
  48. Jiang Z, Chen J, Lou J, Miao C, Shao D, Zhang X. [Monitoring and analysis of asbestos concentration in working environment of different asbestos-producing technologies in a certain area]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2015;33:833-7 pubmed
    ..Most of production technologies in asbestos processing industry exceed the standard level, indicating that the workers were at risk for malignant mesothelioma and other asbestos related diseases, which should draw high attention. ..
  49. Yamada H, Hashimoto H, Akiyama M, Kawabata Y, Iwai K. Talc and amosite/crocidolite preferentially deposited in the lungs of nonoccupational female lung cancer cases in urban areas of Japan. Environ Health Perspect. 1997;105:504-8 pubmed
  50. Puledda S, Ferdinandi M, Plescia P. [First intercalibration test of diffractometric measurements of asbestos in National Italian laboratories]. Med Lav. 1998;89:292-300 pubmed
  51. Borelli V, Trevisan E, Francesca V, Zabucchi G. The Secretory Response of Rat Peritoneal Mast Cells on Exposure to Mineral Fibers. Int J Environ Res Public Health. 2018;15: pubmed publisher
  52. Cammisuli F, Giordani S, Gianoncelli A, Rizzardi C, Radillo L, Zweyer M, et al. Iron-related toxicity of single-walled carbon nanotubes and crocidolite fibres in human mesothelial cells investigated by Synchrotron XRF microscopy. Sci Rep. 2018;8:706 pubmed publisher
    ..Interestingly, highly purified nanotubes did not altered iron metabolism. The data provide new insights for possible CNTs effects at mesothelial/pleural level in humans. ..
  53. Adamson I. Early mesothelial cell proliferation after asbestos exposure: in vivo and in vitro studies. Environ Health Perspect. 1997;105 Suppl 5:1205-8 pubmed
    ..The results show that an early growth phase of MC after asbestos exposure appears unrelated to particle translocation to the pleura but is associated with cytokine release, most likely KGF, by lung cells. ..
  54. Ghio A, Tan R, Ghio K, Fattman C, Oury T. Iron accumulation and expression of iron-related proteins following murine exposure to crocidolite. J Environ Pathol Toxicol Oncol. 2009;28:153-62 pubmed
    We tested the postulate that asbestos exposure alters iron homeostasis in the mouse lung. Crocidolite asbestos (100 microg intratracheally) was instilled into C57BL/6 mice. TiO2 served as a control exposure...
  55. Yegles M, Janson X, Dong H, Renier A, Jaurand M. Role of fibre characteristics on cytotoxicity and induction of anaphase/telophase aberrations in rat pleural mesothelial cells in vitro: correlations with in vivo animal findings. Carcinogenesis. 1995;16:2751-8 pubmed
    ..There was no correlation between cytotoxicity and mesothelioma induction; in contrast, a correlation was found between the ability of a sample to produce chromosome missegregation in vitro and mesothelioma in vivo...
  56. Dufresne A, Harrigan M, Masse S, Begin R. Fibers in lung tissues of mesothelioma cases among miners and millers of the township of Asbestos, Quebec. Am J Ind Med. 1995;27:581-92 pubmed
  57. Driscoll K, Carter J, Howard B, Hassenbein D, Janssen Y, Mossman B. Crocidolite activates NF-kappa B and MIP-2 gene expression in rat alveolar epithelial cells. Role of mitochondrial-derived oxidants. Environ Health Perspect. 1998;106 Suppl 5:1171-4 pubmed
    ..In previous studies we found that crocidolite asbestos activates the nuclear translocation of NF-kappa B as well as MIP-2 gene expression in rat alveolar type II ..
  58. Alfonso H, Fritschi L, de Klerk N, Ambrosini G, Beilby J, Olsen N, et al. Plasma vitamin concentrations and incidence of mesothelioma and lung cancer in individuals exposed to crocidolite at Wittenoom, Western Australia. Eur J Cancer Prev. 2006;15:290-4 pubmed
    ..These findings suggest that people with chronically low plasma levels of retinol have increased risk of developing mesothelioma and lung cancer...
  59. Reid A, Heyworth J, de Klerk N, Musk B. Cancer incidence among women and girls environmentally and occupationally exposed to blue asbestos at Wittenoom, Western Australia. Int J Cancer. 2008;122:2337-44 pubmed
    ..Forty years after the asbestos mine and mill at Wittenoom were closed, there is a high toll from cancer among the former female residents of the town and company workers...
  60. Riganti C, Doublier S, Aldieri E, Orecchia S, Betta P, Gazzano E, et al. Asbestos induces doxorubicin resistance in MM98 mesothelioma cells via HIF-1alpha. Eur Respir J. 2008;32:443-51 pubmed publisher
    ..After 24-h incubation with crocidolite asbestos or with the iron chelator dexrazoxane, or under hypoxia, HMM cells were tested for HIF-1alpha activation, ..
  61. Janssen Y, Driscoll K, Timblin C, Hassenbein D, Mossman B. Modulation of mitochondrial gene expression in pulmonary epithelial cells exposed to oxidants. Environ Health Perspect. 1998;106 Suppl 5:1191-5 pubmed
    ..elucidate genes that are induced or repressed after exposure of rat lung epithelial (RLE) cells to H2O2 or crocidolite asbestos, a pathogenic mineral that generates oxidants...
  62. Michel J, Catilina P, Laubignat J, Gabrillargues D. [Is there criteria to allow the selection of patients exposed to asbestos which is relevant to thoracic computed tomography screening?]. J Radiol. 1999;80:141-5 pubmed
    ..This study was undertaken to determine whether certain criteria could be used to select among asbestos-exposed subjects those who could benefit from computed tomography screening...
  63. Rihn B, Coulais C, Kauffer E, Bottin M, Martin P, Yvon F, et al. Inhaled crocidolite mutagenicity in lung DNA. Environ Health Perspect. 2000;108:341-6 pubmed
    ..We used the (32)P-postlabeling method and did not detect any increase of either 5 mC or bulky adduct in treated mice. This is the first study that demonstrates asbestos mutagenicity in vivo after a nose-only inhalation...
  64. Shen Z, Bosbach D, Hochella M, Bish D, Williams M, Dodson R, et al. Using in vitro iron deposition on asbestos to model asbestos bodies formed in human lung. Chem Res Toxicol. 2000;13:913-21 pubmed
    ..Therefore, fibers carefully loaded with Fe(III) in vitro may be a particularly appropriate and useful model for the study of chemical characteristics associated with asbestos bodies and their potential for interactions in a biosystem...
  65. Iwagaki A, Choe N, Li Y, Hemenway D, Kagan E. Asbestos inhalation induces tyrosine nitration associated with extracellular signal-regulated kinase 1/2 activation in the rat lung. Am J Respir Cell Mol Biol. 2003;28:51-60 pubmed
    ..These findings suggest that asbestos fibers may activate the ERK signaling pathway by generating ONOO- or other nitrating species that induce tyrosine nitration and phosphorylation of critical signaling molecules...
  66. Pociask D, Sime P, Brody A. Asbestos-derived reactive oxygen species activate TGF-beta1. Lab Invest. 2004;84:1013-23 pubmed
    ..We show here that reactive oxygen species (ROS), generated by the iron in chrysotile or crocidolite asbestos, mediate the biological activity of TGF-beta1...
  67. Cavallo D, Campopiano A, Cardinali G, Casciardi S, De Simone P, Kovacs D, et al. Cytotoxic and oxidative effects induced by man-made vitreous fibers (MMVFs) in a human mesothelial cell line. Toxicology. 2004;201:219-29 pubmed
    ..by exposure to glass wool (GW), rock wool (RW) and refractory ceramic fibers (RCF) in comparison with crocidolite asbestos (CR)...
  68. Daghino S, Turci F, Tomatis M, Favier A, Perotto S, Douki T, et al. Soil fungi reduce the iron content and the DNA damaging effects of asbestos fibers. Environ Sci Technol. 2006;40:5793-8 pubmed
    ..Fungi may thus be regarded as appropriate candidates for bioremediation of asbestos rich soils whereby the reactive iron ions responsible for DNA damage are progressively removed from the fibers...
  69. Manning C, Sabo Attwood T, Robledo R, Macpherson M, Rincon M, Vacek P, et al. Targeting the MEK1 cascade in lung epithelium inhibits proliferation and fibrogenesis by asbestos. Am J Respir Cell Mol Biol. 2008;38:618-26 pubmed publisher
    ..Transgene-positive (Tg+) (i.e., dnMEK1) and transgene-negative (Tg-) littermates were exposed to crocidolite asbestos for 2, 4, 9, and 32 days or maintained in clean air (sham controls)...
  70. Fenoglio I, Prandi L, Tomatis M, Fubini B. Free radical generation in the toxicity of inhaled mineral particles: the role of iron speciation at the surface of asbestos and silica. Redox Rep. 2001;6:235-41 pubmed
    ..In order to investigate the role played by iron, fibres of crocidolite asbestos have been modified by thermal treatments to alter their surface iron content...
  71. Britton M. The epidemiology of mesothelioma. Semin Oncol. 2002;29:18-25 pubmed
    ..This review will deal with the epidemiology of mesothelioma with particular attention to the studies that elucidate the impact of various asbestos fiber types on the etiology of the disease...
  72. Cullen R, Miller B, Clark S, Davis J. Tumorigenicity of cellulose fibers injected into the rat peritoneal cavity. Inhal Toxicol. 2002;14:685-703 pubmed
    ..A sample of respirable crocidolite asbestos, known to produce mesotheliomas in rats, was used as a positive control...
  73. Reid A, Ambrosini G, de Klerk N, Fritschi L, Musk B. Aerodigestive and gastrointestinal tract cancers and exposure to crocidolite (blue asbestos): incidence and mortality among former crocidolite workers. Int J Cancer. 2004;111:757-61 pubmed
    ..The excess mortality from upper aerodigestive cancers seen in this cohort of former asbestos workers compared to the Western Australian male population does not appear to be associated with exposure to crocidolite...
  74. Barlow C, Barrett T, Shukla A, Mossman B, Lounsbury K. Asbestos-mediated CREB phosphorylation is regulated by protein kinase A and extracellular signal-regulated kinases 1/2. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1361-9 pubmed
    ..Persistent CREB phosphorylation was observed in lung sections from mice following inhalation of crocidolite asbestos. Exposure of C10 lung epithelial cells to crocidolite asbestos led to rapid CREB phosphorylation and ..
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    ..The authors tested imatinib mesylate in vivo in a mouse model of crocidolite asbestos-induced progressive fibrosis...
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    ..Eight per cent of deaths among these women to the end of 2004 have been from malignant mesothelioma of the pleura...
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    ..This implies that the newly importing countries can confidently expect an increase in asbestos-related disease and death well into the twenty-first century, even if the trade ceased now...
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    ..We conclude that BAL fluids from patients exposed to asbestos contain mitogens for human lung fibroblasts, but that PDGF, TNF-alpha, IGF-1, or IL-1 beta do not contribute to this activity...
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    ..The conclusion of the findings indicates that the individuals had an appreciable homogeneous exposure to crocidolite asbestos.
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    ..In 1983, researchers from the West China University of Medical Sciences (WCUMS) discovered that residents of two villages in Da-yao had hyperendemic pleural plaques and excessive numbers of pleural mesotheliomas...
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    ..The study revealed that at appropriate concentrations DAS protects mesothlelial cells against asbestos induced genotoxicity...
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    ..These results underline the importance of further human epidemiological studies and the need for the determination of a hygienic standard...
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    ..Thus, the number of transformants correlated with that of 6-9 microm crocidolite aggregates...
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    ..These data suggest that MKP-1, through increased expression and lack of oxidation, modulates the inflammatory response in alveolar macrophages exposed to asbestos...
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    ..Blue asbestos was mined and milled at Wittenoom in Western Australia between 1943 and 1966...
  92. de Klerk N, Musk A, Ambrosini G, Eccles J, Hansen J, Olsen N, et al. Vitamin A and cancer prevention II: comparison of the effects of retinol and beta-carotene. Int J Cancer. 1998;75:362-7 pubmed
    ..The finding of significantly lower rates of mesothelioma among subjects assigned to retinol requires further investigation...