lithium compounds

Summary

Summary: Inorganic compounds that contain lithium as an integral part of the molecule.

Top Publications

  1. McCarthy M, Welsh D. Cellular circadian clocks in mood disorders. J Biol Rhythms. 2012;27:339-52 pubmed
    ..This approach, informed by the new insights and tools of modern chronobiology, will allow a more definitive test of the role of cellular circadian clocks in mood disorders...
  2. Nivoli A, Murru A, Vieta E. Lithium: still a cornerstone in the long-term treatment in bipolar disorder?. Neuropsychobiology. 2010;62:27-35 pubmed publisher
    ..Despite its worldwide clinical use, the effectiveness of lithium has been questioned. The aim of this work is to critically review the available data on randomized controlled trials (RCTs) concerning long-term lithium treatment...
  3. Muller Oerlinghausen B, Lewitzka U. Lithium reduces pathological aggression and suicidality: a mini-review. Neuropsychobiology. 2010;62:43-9 pubmed publisher
  4. Serretti A, Drago A. Pharmacogenetics of lithium long-term treatment: focus on initiation and adaptation mechanisms. Neuropsychobiology. 2010;62:61-71 pubmed publisher
    ..Moreover, the pharmacogenetics reports that are not strictly associated with the mechanisms that are thought to be acutely and chronically elicited by lithium will be included in the final part of the paper...
  5. Schulze T, Alda M, Adli M, Akula N, Ardau R, Bui E, et al. The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment. Neuropsychobiology. 2010;62:72-8 pubmed publisher
    ..A stringent phenotype definition of response is one of the hallmarks of this collaboration. ConLiGen invites all lithium researchers to join its efforts...
  6. Paton C, Barnes T, Shingleton Smith A, McAllister Williams R, Kirkbride J, Jones P, et al. Lithium in bipolar and other affective disorders: prescribing practice in the UK. J Psychopharmacol. 2010;24:1739-46 pubmed publisher
    ..A significant minority of patients prescribed lithium had a sub-therapeutic blood level and so may be at high risk of relapse...
  7. Pasquali L, Busceti C, Fulceri F, Paparelli A, Fornai F. Intracellular pathways underlying the effects of lithium. Behav Pharmacol. 2010;21:473-92 pubmed publisher
    ..This review is an attempt to elucidate the primary effects of lithium to interconnect the simpler targets to the most complex pharmacological effects...
  8. van Erp T, Thompson P, Kieseppä T, Bearden C, Marino A, Hoftman G, et al. Hippocampal morphology in lithium and non-lithium-treated bipolar I disorder patients, non-bipolar co-twins, and control twins. Hum Brain Mapp. 2012;33:501-10 pubmed publisher
    ..We examined familial contributions to hippocampal morphology in bipolar disorder, using a population-based twin cohort design...
  9. Squassina A, Manchia M, Borg J, Congiu D, Costa M, Georgitsi M, et al. Evidence for association of an ACCN1 gene variant with response to lithium treatment in Sardinian patients with bipolar disorder. Pharmacogenomics. 2011;12:1559-69 pubmed publisher
    ..Here, we present the results of an exploratory genome-wide scan followed by extended genotyping carried out on a sample of 204 Sardinian BD patients characterized for lithium response...

More Information

Publications78

  1. Forlenza O, De Paula V, Machado Vieira R, Diniz B, Gattaz W. Does lithium prevent Alzheimer's disease?. Drugs Aging. 2012;29:335-42 pubmed publisher
  2. Han M, Neves A, Serrano M, Brinez P, Huhta J, Acharya G, et al. Effects of alcohol, lithium, and homocysteine on nonmuscle myosin-II in the mouse placenta and human trophoblasts. Am J Obstet Gynecol. 2012;207:140.e7-19 pubmed publisher
  3. Camins A, Crespo Biel N, Junyent F, Verdaguer E, Canudas A, Pallas M. Calpains as a target for therapy of neurodegenerative diseases: putative role of lithium. Curr Drug Metab. 2009;10:433-47 pubmed
  4. Roybal K, Theobold D, Graham A, DiNieri J, Russo S, Krishnan V, et al. Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A. 2007;104:6406-11 pubmed
    ..These findings establish the Clock mutant mice as a previously unrecognized model of human mania and reveal an important role for CLOCK in the dopaminergic system in regulating behavior and mood...
  5. Fornai F, Longone P, Cafaro L, Kastsiuchenka O, Ferrucci M, Manca M, et al. Lithium delays progression of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2008;105:2052-7 pubmed publisher
    ..All these mechanisms may contribute to the effects of lithium, and these results offer a promising perspective for the treatment of human patients affected by ALS...
  6. Manchia M, Congiu D, Squassina A, Lampus S, Ardau R, Chillotti C, et al. No association between lithium full responders and the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes in a Sardinian sample. Psychiatry Res. 2009;169:164-6 pubmed publisher
    ..No significant association was shown between the polymorphisms of the genes studied and response to lithium treatment...
  7. Zhou R, Yuan P, Wang Y, Hunsberger J, Elkahloun A, Wei Y, et al. Evidence for selective microRNAs and their effectors as common long-term targets for the actions of mood stabilizers. Neuropsychopharmacology. 2009;34:1395-405 pubmed publisher
    ..These findings are the first to demonstrate that miRNAs and their predicted effectors are targets for the action of psychotherapeutic drugs...
  8. Corena McLeod M, Oliveros A, Charlesworth C, Madden B, Liang Y, Boules M, et al. Paliperidone as a mood stabilizer: a pre-frontal cortex synaptoneurosomal proteomics comparison with lithium and valproic acid after chronic treatment reveals similarities in protein expression. Brain Res. 2008;1233:8-19 pubmed publisher
  9. O Brien W, Klein P. Validating GSK3 as an in vivo target of lithium action. Biochem Soc Trans. 2009;37:1133-8 pubmed publisher
    ..These observations, from several independent laboratories, support a central role for GSK3 in mediating behavioural responses to lithium...
  10. Aral H, Vecchio Sadus A. Toxicity of lithium to humans and the environment--a literature review. Ecotoxicol Environ Saf. 2008;70:349-56 pubmed publisher
    ..At 15 mg/L they experience confusion and speech impairment, and at 20 mg/L Li there is a risk of death. A provisional recommended daily intake of 14.3 microg/kg body weight lithium for an adult has been suggested...
  11. Quiroz J, Gould T, Manji H. Molecular effects of lithium. Mol Interv. 2004;4:259-72 pubmed
    ..Many of the new insights of lithium's actions may lead to the strategic development of improved therapeutics for the treatment of bipolar disorder...
  12. Perlis R, Purcell S, Fagerness J, Kirby A, Petryshen T, Fan J, et al. Family-based association study of lithium-related and other candidate genes in bipolar disorder. Arch Gen Psychiatry. 2008;65:53-61 pubmed publisher
    ..Recent developments suggest that a broader pool of genes may be associated with this disorder...
  13. Bassilios N, Martel P, Godard V, Froissart M, Grunfeld J, Stengel B. Monitoring of glomerular filtration rate in lithium-treated outpatients--an ambulatory laboratory database surveillance. Nephrol Dial Transplant. 2008;23:562-5 pubmed
    ..The long-term risk of chronic kidney disease (CKD) in lithium (Li)-treated patients has been well established in the recent years...
  14. Chuang D, Manji H. In search of the Holy Grail for the treatment of neurodegenerative disorders: has a simple cation been overlooked?. Biol Psychiatry. 2007;62:4-6 pubmed
  15. Yatham L, Vieta E, Young A, Moller H, Paulsson B, Vågerö M. A double blind, randomized, placebo-controlled trial of quetiapine as an add-on therapy to lithium or divalproex for the treatment of bipolar mania. Int Clin Psychopharmacol. 2007;22:212-20 pubmed
    ..Overall, the combination of quetiapine with lithium or divalproex was well tolerated...
  16. Manchia M, Squassina A, Congiu D, Chillotti C, Ardau R, Severino G, et al. Interacting genes in lithium prophylaxis: preliminary results of an exploratory analysis on the role of DGKH and NR1D1 gene polymorphisms in 199 Sardinian bipolar patients. Neurosci Lett. 2009;467:67-71 pubmed publisher
    ..Moreover, the lack of statistic interaction might not necessarily correspond to a lack of biologic interaction between the genes studied...
  17. Belmaker R. Bipolar disorder. N Engl J Med. 2004;351:476-86 pubmed
  18. Vieta E, Rosa A. Evolving trends in the long-term treatment of bipolar disorder. World J Biol Psychiatry. 2007;8:4-11 pubmed
    ..The role of psychoeducation in improving adherence to medication in long-term treatment and overall patient outcomes is also crucial...
  19. Yatham L, Binder C, Kusumakar V, Riccardelli R. Risperidone plus lithium versus risperidone plus valproate in acute and continuation treatment of mania. Int Clin Psychopharmacol. 2004;19:103-9 pubmed
    ..These data suggest that risperidone can be safely combined with either lithium or valproate, and that the efficacy is similar regardless of the mood stabilizer used...
  20. Beurel E, Jope R. Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain. J Neuroinflammation. 2009;6:9 pubmed publisher
    ..To identify potential targets to control brain IL-6, we tested if IL-6 produced by glia is regulated by signal transducer and activator of transcription-3 (STAT3) and glycogen synthase kinase-3 (GSK3)...
  21. Beaulieu J, Gainetdinov R, Caron M. Akt/GSK3 signaling in the action of psychotropic drugs. Annu Rev Pharmacol Toxicol. 2009;49:327-47 pubmed publisher
    ..Elucidation of the contribution of multiple signaling pathways to the action of psychotropic drugs may provide a better biological understanding of psychiatric disorders and lead to more efficient therapeutics...
  22. Squassina A, Congiu D, Manconi F, Manchia M, Chillotti C, Lampus S, et al. The PDLIM5 gene and lithium prophylaxis: an association and gene expression analysis in Sardinian patients with bipolar disorder. Pharmacol Res. 2008;57:369-73 pubmed publisher
    ..Our negative findings do not exclude involvement of PDLIM5 in lithium prophylaxis, and further investigation is warranted...
  23. Omata N, Murata T, Takamatsu S, Maruoka N, Mitsuya H, Yonekura Y, et al. Neuroprotective effect of chronic lithium treatment against hypoxia in specific brain regions with upregulation of cAMP response element binding protein and brain-derived neurotrophic factor but not nerve growth factor: comparison with acute lithium . Bipolar Disord. 2008;10:360-8 pubmed publisher
    ..Furthermore, we investigated the contribution of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and cAMP response element binding protein (CREB) to the neuroprotective effect of lithium...
  24. Livingstone C, Rampes H. Lithium: a review of its metabolic adverse effects. J Psychopharmacol. 2006;20:347-55 pubmed
    ..We review aspects of these actions of lithium including their prevalence, risk factors, biochemical changes involved and management, and discuss some advances that have been made in their understanding in recent years...
  25. Liang J, Fuh J, Yu H, Hsu C, Wang S. Clinical features, polysomnography and outcome in patients with hypnic headache. Cephalalgia. 2008;28:209-15 pubmed publisher
    ..The major reason was the presence of pulsatile rather than dull headache in our patients. Unlike previous studies, our study showed hypnic headache occurred equally in both REM and non-REM sleep, and most patients ran an episodic course...
  26. Grof P, Muller Oerlinghausen B. A critical appraisal of lithium's efficacy and effectiveness: the last 60 years. Bipolar Disord. 2009;11 Suppl 2:10-9 pubmed publisher
    ..More recently, lithium has also proven to dramatically reduce suicidal behavior and mortality and to augment markedly the efficacy of antidepressants in unresponsive patients...
  27. Benedetti F, Dallaspezia S, Fulgosi M, Lorenzi C, Serretti A, Barbini B, et al. Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:631-5 pubmed
    ..Individual characteristics of the molecular clock can influence sleep symptoms in mood disorders...
  28. Masui T, Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, et al. A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:204-8 pubmed
    ..We found that the allele frequency of Ser796 was significantly higher in non-responders than in responders. Further investigation is warranted to confirm our findings...
  29. Bian Q, Shi T, Chuang D, Qian Y. Lithium reduces ischemia-induced hippocampal CA1 damage and behavioral deficits in gerbils. Brain Res. 2007;1184:270-6 pubmed
    ..These results underscore the ability of lithium to improve functional behavioral outcome in gerbil and rodent cerebral ischemic models and further indicate the potential therapeutic use of lithium in certain human stroke conditions...
  30. Mamdani F, Alda M, Grof P, Young L, Rouleau G, Turecki G. Lithium response and genetic variation in the CREB family of genes. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:500-4 pubmed publisher
    ..Following correction for multiple testing, our results suggest that the CREB1-1H SNP (G/A change, P < 0.002) and the CREB1-7H SNP (T/C change, P < 0.002) may be associated with BD and/or lithium response...
  31. Silberberg G, Levit A, Collier D, St Clair D, Munro J, Kerwin R, et al. Stargazin involvement with bipolar disorder and response to lithium treatment. Pharmacogenet Genomics. 2008;18:403-12 pubmed publisher
  32. Miller J, Jimenez P, Mathe A. Restraint stress influences AP-1 and CREB DNA-binding activity induced by chronic lithium treatment in the rat frontal cortex and hippocampus. Int J Neuropsychopharmacol. 2007;10:609-19 pubmed
    ..Our findings of increased AP-1 and CREB binding after lithium are consistent with lithium's inhibitory effect on glycogen synthase kinase-3beta, which has been show to negatively regulate AP-1 and CREB transcriptional activity...
  33. Szczepankiewicz A, Skibińska M, Suwalska A, Hauser J, Rybakowski J. No association of three GRIN2B polymorphisms with lithium response in bipolar patients. Pharmacol Rep. 2009;61:448-52 pubmed
    ..The authors conclude that polymorphisms of the GRIN2B gene did not show an association with the treatment response to lithium in bipolar patients. ..
  34. Machado Vieira R, Manji H, Zarate C. The role of lithium in the treatment of bipolar disorder: convergent evidence for neurotrophic effects as a unifying hypothesis. Bipolar Disord. 2009;11 Suppl 2:92-109 pubmed publisher
    ..Continued work to decipher lithium's molecular actions will likely lead to the development of not only improved therapeutics for BD, but to neurotrophic enhancers that could prove useful in the treatment of many other illnesses...
  35. Bremer T, Diamond C, McKinney R, Shehktman T, Barrett T, Herold C, et al. The pharmacogenetics of lithium response depends upon clinical co-morbidity. Mol Diagn Ther. 2007;11:161-70 pubmed
    ..A test that could predict response to lithium based upon genetic factors would have significant clinical value...
  36. Backlund L, Ehnvall A, Hetta J, Isacsson G, Agren H. Identifying predictors for good lithium response - a retrospective analysis of 100 patients with bipolar disorder using a life-charting method. Eur Psychiatry. 2009;24:171-7 pubmed publisher
    ..Our aim was to investigate bipolar patients in order to test the validity of various outcome measures and to identify prognostic predictors for pharmacological treatment...
  37. Fatemi S, Reutiman T, Folsom T. The role of lithium in modulation of brain genes: relevance for aetiology and treatment of bipolar disorder. Biochem Soc Trans. 2009;37:1090-5 pubmed publisher
  38. Sarti G, Del Dottore F, Fabbri C, Tassinari L, Pagan S, Rustignoli M, et al. Individual monitoring in nuclear medicine therapeutic procedures using extremity dosemeters LiF(Mg, Cu, P). Radiat Prot Dosimetry. 2011;144:521-4 pubmed publisher
    ..This method reveals the critical step of manipulation and administration and ensures that dose limits are not exceeded. ..
  39. Gold A, Herrmann N, Lanctot K. Lithium and its neuroprotective and neurotrophic effects: potential treatment for post-ischemic stroke sequelae. Curr Drug Targets. 2011;12:243-55 pubmed
  40. Yu H, Wu H, Pan S, Wang Y, Yang Z, Su X. New salt-inclusion borate, Li3Ca9(BO3)7·2[LiF]: a promising UV NLO material with the coplanar and high density BO3 triangles. Inorg Chem. 2013;52:5359-65 pubmed publisher
    ..And interestingly, LCBF is a salt-inclusion borate with the Li-F chains residing in the one-dimensional open framework, which caters to the development of the salt-inclusion compound in borate. ..
  41. Vasudev A, MacRitchie K, Vasudev K, Watson S, Geddes J, Young A. Oxcarbazepine for acute affective episodes in bipolar disorder. Cochrane Database Syst Rev. 2011;:CD004857 pubmed publisher
    ..There is a need for adequately powered randomised controlled trials of good methodological quality to inform us of the therapeutic potential of oxcarbazepine across the spectrum of acute episodes in bipolar disorder. ..
  42. Kang Z, Rosson R, Barta M, Nadler J, Wagner B, Kahn B. GdBr3: CE in a glass wafer as a nuclear radiation monitor. Health Phys. 2013;104:504-10 pubmed publisher
  43. Kohler S, Unger T, Hoffmann S, Steinacher B, Fydrich T, Bschor T. Comparing augmentation with non-antidepressants over sticking to antidepressants after treatment failure in depression: a naturalistic study. Pharmacopsychiatry. 2013;46:69-76 pubmed publisher
    ..The lack of randomization and absence of a non-response definition are design flaws. Controlled studies are required to confirm the findings of this trial. ..
  44. González Isasi A, Echeburua E, Limiñana J, Gonzalez Pinto A. Predictors of good outcome in patients with refractory bipolar disorder after a drug or a drug and cognitive-behavioral treatment. Compr Psychiatry. 2012;53:224-9 pubmed publisher
    ..Differently from other studies, no significant influences of age, sex, subsyndromal symptoms, anxiety, and depression symptoms on the prognosis of refractory bipolar disorder were observed in our study. ..
  45. Li X, Zeng Y, Zhang X, Zheng S, Meng L. Insight into the lithium/hydrogen bonding in (CH2)2X...LiY/HY (X: C=CH2, O, S; Y=F, Cl, Br) complexes. J Mol Model. 2011;17:757-67 pubmed publisher
    ..Electron transfer plays an important role in the formation of lithium bond systems while it is less important in the hydrogen bond systems. ..
  46. Cipriani A, Reid K, Young A, MacRitchie K, Geddes J. Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder. Cochrane Database Syst Rev. 2013;:CD003196 pubmed publisher
    ..Clinicians and patients should consider acceptability and tolerability profile when choosing between lithium and valproate-their combination or other agents-as long-term treatment for bipolar disorder. ..
  47. Kalman J. [Sense and sensibility: bipolar affective disorder as a battlefield of cognitions and emotions--lamotrigine therapy as a peacekeeper]. Neuropsychopharmacol Hung. 2010;12:357-68 pubmed
    ..In addition, neuroprotective properties of the same molecule might also be beneficial regarding the proposed pathomechanism of BAD. ..
  48. Song D, Li B, Yan E, Man Y, Wolfson M, Chen Y, et al. Chronic treatment with anti-bipolar drugs causes intracellular alkalinization in astrocytes, altering their functions. Neurochem Res. 2012;37:2524-40 pubmed publisher
    ..Whenever tested, identical effects were observed in freshly isolated astrocytes, but not neurons, from carbamazepine-treated healthy animals. ..
  49. Bauer M, Adli M, Bschor T, Pilhatsch M, Pfennig A, Sasse J, et al. Lithium's emerging role in the treatment of refractory major depressive episodes: augmentation of antidepressants. Neuropsychobiology. 2010;62:36-42 pubmed publisher
    ..Augmentation of antidepressants with lithium is currently the best-evidenced augmentation therapy in the treatment of depressed patients who do not respond to antidepressants. ..
  50. Berkol T, Kırlı E, Islam S, Pınarbaşı R, Özyıldırım Ä. Comparison of clinical and sociodemographic features of bipolar disorder patients with those of social anxiety disorder patients comorbid with bipolar disorder in Turkey. Saudi Med J. 2016;37:309-14 pubmed publisher
    ..Social anxiety disorder comorbidity may be associated with more severe episodes and early onset of BD. However, SAD comorbidity may not be related to treatment response in bipolar patients. ..
  51. Helbich M, Leitner M, Kapusta N. Geospatial examination of lithium in drinking water and suicide mortality. Int J Health Geogr. 2012;11:19 pubmed publisher
  52. van der Lugt N, van de Maat J, Van Kamp I, Knoppert van der Klein E, Hovens J, Walther F. Fetal, neonatal and developmental outcomes of lithium-exposed pregnancies. Early Hum Dev. 2012;88:375-8 pubmed publisher
    ..Growth, behavior and general development were within the normal range. Continuing lithium therapy during pregnancy did not cause adverse effects on growth, neurological, cognitive and behavioral development of exposed children. ..
  53. Schenk C, Kracke A, Fink K, Kubas A, Klopper W, Neumaier M, et al. The formal combination of three singlet biradicaloid entities to a singlet hexaradicaloid metalloid Ge14[Si(SiMe3)3]5[Li(THF)2]3 cluster. J Am Chem Soc. 2011;133:2518-24 pubmed publisher
    ..The unique multiradicaloid bonding character of the metalloid cluster 1 might be used as a model for reactions and properties in the field of surface science and nanotechnology. ..
  54. Suleymanova E, Gulyaev M, Abbasova K. Structural alterations in the rat brain and behavioral impairment after status epilepticus: An MRI study. Neuroscience. 2016;315:79-90 pubmed publisher
    ..Therefore, the amygdala damage may be an important factor in the development of hyperactivity in the chronic period after SE. ..
  55. Yang Q, Wu C, Saito T, Isogai A. Cellulose-clay layered nanocomposite films fabricated from aqueous cellulose/LiOH/urea solution. Carbohydr Polym. 2014;100:179-84 pubmed publisher
    ..This is probably because the orientation of cellulose chains on the film surface changes by the formation of numerous hydrogen bonds between cellulose molecules and MTM platelets. ..
  56. Mohandoss R, Dhanuskodi S, Sanjeeviraja C. Optical studies on electron beam evaporated lithium triborate films. Spectrochim Acta A Mol Biomol Spectrosc. 2012;96:805-8 pubmed publisher
    ..The nonlinear refractive index (n(2)~10(-16) cm(2)/W) and nonlinear absorption coefficient (?~10(-2) cm/W) reveal (Z-scan technique) that the material has negative nonlinearity and self-focusing nature...
  57. Huang C, Hsueh C. Piston-on-three-ball versus piston-on-ring in evaluating the biaxial strength of dental ceramics. Dent Mater. 2011;27:e117-23 pubmed publisher
    ..The purpose of the present study is to evaluate the adequacy of applying the formula for piston-on-ring to piston-on-three-ball tests for both monolayered and multilayered discs...
  58. Forlenza O, Diniz B, Radanovic M, Santos F, Talib L, Gattaz W. Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial. Br J Psychiatry. 2011;198:351-6 pubmed publisher
    ..Overall tolerability of lithium was good and the adherence rate was 91%. The present data support the notion that lithium has disease-modifying properties with potential clinical implications in the prevention of Alzheimer's disease. ..
  59. González P, Furetta C, Cruz Zaragoza E. New modified expressions for isothermal decay of Teflon embedded LiF:Mg,Cu,P and BaSO4:Eu phosphors. Appl Radiat Isot. 2011;69:511-5 pubmed publisher
    ..The isothermal decay method was applied to the principal glow peaks of two different phosphors: LiF:Mg,Cu,P+PTFE, using first- and second-order kinetics, and BaSO(4):Eu+PTFE, using second-order kinetics...
  60. Buoli M, Serati M, Cahn W. Alternative pharmacological strategies for adult ADHD treatment: a systematic review. Expert Rev Neurother. 2016;16:131-44 pubmed publisher
    ..Finally metadoxine and lithium may be particularly suitable in case of comorbid alcohol misuse or bipolar disorder. ..
  61. van der Loos M, Mulder P, Hartong E, Blom M, Vergouwen A, van Noorden M, et al. Long-term outcome of bipolar depressed patients receiving lamotrigine as add-on to lithium with the possibility of the addition of paroxetine in nonresponders: a randomized, placebo-controlled trial with a novel design. Bipolar Disord. 2011;13:111-7 pubmed publisher
    ..In this paper we describe the long-term (68 weeks) outcome of that study...
  62. Bergink V, Kushner S, Pop V, Kuijpens H, Lambregtse van den Berg M, Drexhage R, et al. Prevalence of autoimmune thyroid dysfunction in postpartum psychosis. Br J Psychiatry. 2011;198:264-8 pubmed publisher
    ..Further, AITD represents a potentially strong aetiological factor for the development of postpartum psychosis. Therefore, screening for thyroperoxidase antibodies is warranted in patients with postpartum psychosis. ..
  63. Greil W, Häberle A, Haueis P, Grohmann R, Russmann S. Pharmacotherapeutic trends in 2231 psychiatric inpatients with bipolar depression from the International AMSP Project between 1994 and 2009. J Affect Disord. 2012;136:534-42 pubmed publisher
    ..Pharmacological treatment of bipolar depression is a complex and controversial issue, and its real-world practice remains largely unknown...
  64. Chiang C, Ju M, Lin C. Description and computational modeling of the whole course of status epilepticus induced by low dose lithium-pilocarpine in rats. Brain Res. 2011;1417:151-62 pubmed publisher
    ..The changes of the parameters in the model were compatible with the experimental results in the literature...
  65. Dupke S, Langer T, Pöttgen R, Winter M, Eckert H. Structural and dynamic characterization of Li(12)Si(7) and Li(12)Ge(7) using solid state NMR. Solid State Nucl Magn Reson. 2012;42:17-25 pubmed publisher
    ..Variable temperature static (7)Li NMR spectra reveal the onset of strong motional narrowing effects, illustrating high lithium ionic mobilities in both of these compounds...
  66. Chung A. Atypical presentation of tardive dyskinesia associated with risperidone long-acting injection as maintenance treatment in bipolar affective disorder: a case report. Curr Drug Saf. 2012;7:21-3 pubmed
    ..The case reported here a bipolar patient with atypical presentation of TD involving only the crico-hyoid region of the neck associated with the use of risperidone LAI in adjunct to lithium and sodium valproate as maintenance therapy...
  67. Parker G, McCraw S, Fletcher K. Cyclothymia. Depress Anxiety. 2012;29:487-94 pubmed publisher
  68. Gordji Nejad A, Colell J, Glöggler S, Blumich B, Appelt S. Studies of ?Li-NMR properties in different salt solutions in low magnetic fields. J Magn Reson. 2012;214:10-4 pubmed publisher
    ..By diluting the solution, the precipitate continuously dissolves and approaches T(1) of (6)LiOH (T(1)?28s), leading to a shorter T(1) relaxation time...
  69. Arraf Z, Amit T, Youdim M, Farah R. Lithium and oxidative stress lessons from the MPTP model of Parkinson's disease. Neurosci Lett. 2012;516:57-61 pubmed publisher
    ..In agreement; we found that lithium lacks immediate antioxidant activity using the in vitro lipid peroxidation essay indicating that not acute but chronic treatment with lithium allows cells to deal better with oxidative stress...