sulfur radioisotopes


Summary: Unstable isotopes of sulfur that decay or disintegrate spontaneously emitting radiation. S 29-31, 35, 37, and 38 are radioactive sulfur isotopes.

Top Publications

  1. de Ligt R, Rivkees S, Lorenzen A, Leurs R, IJzerman A. A "locked-on," constitutively active mutant of the adenosine A1 receptor. Eur J Pharmacol. 2005;510:1-8 pubmed
    ..e., neither agonist nor inverse agonist was capable of modulating the basal activity in both the GTPgammaS and the cAMP assay, unlike the wild-type and the two other mutant receptors...
  2. Nagai K, Tadano Aritomi K, Iida Tanaka N, Yoshizawa H, Ishizuka I. Metabolism of sulfolipids in isolated renal tubules from rat. Comp Biochem Physiol B Biochem Mol Biol. 2005;140:487-95 pubmed
    ..By using the present system, we showed that biosynthesis of the renal total sulfoglycolipid was significantly elevated in rats deprived of water for 24 h...
  3. Su D, Markowitz M, Murphy K, Wan B, Zrada M, Harrell C, et al. Development of an efficient and selective radioligand for bradykinin B1 receptor occupancy studies. Bioorg Med Chem Lett. 2004;14:6045-8 pubmed
    ..We have developed an efficient and selective radioligand, the [35S]-radiolabeled dihydroquinoxalinone derivative, 4, for an ex vivo receptor occupancy assay in transgenic rats over-expressing the human bradykinin B1 receptor. ..
  4. Wang Y, Tang K, Inan S, Siebert D, Holzgrabe U, Lee D, et al. Comparison of pharmacological activities of three distinct kappa ligands (Salvinorin A, TRK-820 and 3FLB) on kappa opioid receptors in vitro and their antipruritic and antinociceptive activities in vivo. J Pharmacol Exp Ther. 2005;312:220-30 pubmed
    ..The discrepancy between in vitro and in vivo results may be due to in vivo metabolism of salvinorin A and 3FLB and possibly to their effects on other pharmacological targets. ..
  5. Neilan C, Husbands S, Breeden S, Ko M, Aceto M, Lewis J, et al. Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist. Eur J Pharmacol. 2004;499:107-16 pubmed
    ..BU72 is too efficacious for human use but manipulation to reduce efficacy could provide a lead to the development of a treatment for opioid dependence. ..
  6. Jaffrey S, Fang M, Snyder S. Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue. Chem Biol. 2002;9:1329-35 pubmed
    ..Mutagenesis of Cys11 abolished the effect of NO donors on Dexras1, implicating this residue in the NO-mediated activation of Dexras1...
  7. Demarco G, Baghdoyan H, Lydic R. Differential cholinergic activation of G proteins in rat and mouse brainstem: relevance for sleep and nociception. J Comp Neurol. 2003;457:175-84 pubmed
    ..These data provide the first direct measurement of muscarinic receptor-activated G proteins in B6 mouse brainstem nuclei known in other species to regulate sleep...
  8. Kokkola T, Foord S, Watson M, Vakkuri O, Laitinen J. Important amino acids for the function of the human MT1 melatonin receptor. Biochem Pharmacol. 2003;65:1463-71 pubmed
    ..Several important amino acids for the human MT1 melatonin receptor function were revealed in the current study, with effects of mutations ranging from slightly reduced affinity or efficacy to complete loss of function...
  9. McAllister G, Stanton J, Salim K, Handford E, Beer M. Edg2 receptor functionality: gialpha1 coexpression and fusion protein studies. Mol Pharmacol. 2000;58:407-12 pubmed
    ..A limited structure activity relationship study suggests that the lysophospholipid carbon chain has a role in receptor activation and in addition indicates that certain modifications to the phosphate group are tolerated...

More Information

Publications112 found, 100 shown here

  1. Laitinen J, Uri A, Raidaru G, Miettinen R. [(35)S]GTPgammaS autoradiography reveals a wide distribution of G(i/o)-linked ADP receptors in the nervous system: close similarities with the platelet P2Y(ADP) receptor. J Neurochem. 2001;77:505-18 pubmed
    ..These data witness a hitherto unrecognized abundance of G(i/o)-linked ADP receptors in the nervous system. Biochemical and pharmacological behaviour suggests striking similarities to the elusive platelet P2Y(ADP) receptor...
  2. Liu J, Prather P. Chronic exposure to mu-opioid agonists produces constitutive activation of mu-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment. Mol Pharmacol. 2001;60:53-62 pubmed
    ..These observations may lend novel insight into the mechanisms of opioid tolerance and dependence...
  3. Wang D, Raehal K, Bilsky E, Sadee W. Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence. J Neurochem. 2001;77:1590-600 pubmed
    ..Neutral antagonists have promise in treatment of narcotic addiction...
  4. Hu V, Heikka D, Dieffenbach P, Ha L. Metabolic radiolabeling: experimental tool or Trojan horse? (35)S-Methionine induces DNA fragmentation and p53-dependent ROS production. FASEB J. 2001;15:1562-8 pubmed
  5. Huang P, Li J, Chen C, Visiers I, Weinstein H, Liu Chen L. Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp. Biochemistry. 2001;40:13501-9 pubmed
    ..To the best of our knowledge, the results presented here represent the first structurally rationalized demonstration that mutations of this locus can lead to dramatically different properties of a GPCR...
  6. Clark W, Izotova L, Philipova D, Wu W, Lin L, Pestka S. Site-specific 32P-labeling of cytokines, monoclonal antibodies, and other protein substrates for quantitative assays and therapeutic application. Biotechniques. 2002;Suppl:76-8, 80-7 pubmed
    ..Most importantly 32P labeling of monoclonal antibodies or other therapeutic protein candidates has several significant advantages over radioiodination or chemical conjugation of heavy metal isotopes. ..
  7. Chilcott R, Dalton C, Emmanuel A, Allen C, Bradley S. Transepidermal water loss does not correlate with skin barrier function in vitro. J Invest Dermatol. 2002;118:871-5 pubmed
    ..It is clear that further work should be conducted to interpret the significance of measuring transepidermal water loss by evaporimetry. ..
  8. Hrabovszky E, Petersen S. Increased concentrations of radioisotopically-labeled complementary ribonucleic acid probe, dextran sulfate, and dithiothreitol in the hybridization buffer can improve results of in situ hybridization histochemistry. J Histochem Cytochem. 2002;50:1389-400 pubmed
    ..We suggest that the new method using increased concentrations of (35)S-labeled cRNA probe, DS, and DTT will be especially important for the cellular localization of rare mRNA species. ..
  9. Allakhverdiev S, Mohanty P, Murata N. Dissection of photodamage at low temperature and repair in darkness suggests the existence of an intermediate form of photodamaged photosystem II. Biochemistry. 2003;42:14277-83 pubmed
    ..Our findings, together with those of other studies, suggest the presence of an intermediate form of photodamaged PSII that is generated prior to the formation of photodamaged PSII. ..
  10. Roberts D, Lin H, Strange P. Investigation of the mechanism of agonist and inverse agonist action at D2 dopamine receptors. Biochem Pharmacol. 2004;67:1657-65 pubmed
    ..These data do not provide support for the idea that inverse agonists act by binding preferentially to the ground state of the receptor. ..
  11. Hendriks W, Harding D, Rutherfurd Markwick K. Isolation and characterisation of renal metabolites of gamma-glutamylfelinylglycine in the urine of the domestic cat (Felis catus). Comp Biochem Physiol B Biochem Mol Biol. 2004;139:245-51 pubmed
    ..Additionally, our research indicates that previously reported estimates of felinine excretion in male cats need to be increased by as much as 54% to account for other felinine containing metabolites in the urine. ..
  12. Struhl K. Analysis of DNA-protein interactions using proteins synthesized in vitro from cloned genes. Curr Protoc Mol Biol. 2001;Chapter 12:Unit 12.9 pubmed publisher
    ..Major advantages of this method are that any desired mutant protein can be tested for its DNA-binding properties simply by altering the DNA template, and the subunit structure (e.g., dimer, tetramer) can be determined. ..
  13. Hooiveld M, Roosendaal G, Wenting M, van den Berg M, Bijlsma J, Lafeber F. Short-term exposure of cartilage to blood results in chondrocyte apoptosis. Am J Pathol. 2003;162:943-51 pubmed
    ..This reduced restoration could eventually lead to cartilage degeneration and ultimately joint destruction. ..
  14. Heydorn A, Søndergaard B, Hadrup N, Holst B, Haft C, Schwartz T. Distinct in vitro interaction pattern of dopamine receptor subtypes with adaptor proteins involved in post-endocytotic receptor targeting. FEBS Lett. 2004;556:276-80 pubmed
    ..However, SNX1 clearly distinguished between D1 and D5, as only D5 bound strongly to this protein. This report shows that there are distinct interaction patterns for NSF and SNX1 to the various dopamine receptor subtypes. ..
  15. Pugliese A, Trincavelli M, Lecca D, Coppi E, Fumagalli M, Ferrario S, et al. Functional characterization of two isoforms of the P2Y-like receptor GPR17: [35S]GTPgammaS binding and electrophysiological studies in 1321N1 cells. Am J Physiol Cell Physiol. 2009;297:C1028-40 pubmed publisher
  16. Shiba T, Ozu M, Yoshida Y, Mignot E, Nishino S. Hypocretin stimulates [(35)S]GTP gamma S binding in Hcrtr 2-transfected cell lines and in brain homogenate. Biochem Biophys Res Commun. 2002;294:615-20 pubmed
    ..Hypocretin-stimulated [(35)S]GTP gamma S binding, may thus be a useful functional assay for hypocretin receptors in both cell lines and brain tissue homogenates. ..
  17. Sim Selley L, Vogt L, Vogt B, Childers S. Cellular localization of cannabinoid receptors and activated G-proteins in rat anterior cingulate cortex. Life Sci. 2002;71:2217-26 pubmed
  18. Kock H, Gerth U, Hecker M. The ClpP peptidase is the major determinant of bulk protein turnover in Bacillus subtilis. J Bacteriol. 2004;186:5856-64 pubmed
  19. Febo M, González Rodríguez L, Capó Ramos D, González Segarra N, Segarra A. Estrogen-dependent alterations in D2/D3-induced G protein activation in cocaine-sensitized female rats. J Neurochem. 2003;86:405-12 pubmed
    ..These data suggest that changes in D2/D3 receptor function represent one mechanism by which estrogen regulates behavioral sensitization to cocaine. ..
  20. Kasevayuth K, Yanagishita M. Catabolism of heparan sulfate proteoglycans in Drosophila cell lines. Biochem Biophys Res Commun. 2004;324:205-11 pubmed
    ..These experiments suggested that vertebrates and invertebrates shared common mechanisms for intracellular HSPG catabolism. ..
  21. Krumpe K, Rapaport D. An assay to monitor the membrane integration of single-span proteins. Methods Mol Biol. 2013;1033:301-6 pubmed publisher
    ..In this assay non-imported proteins are distinguished from correctly imported protein species by labelling of unprotected cysteine residues and a resulting migration shift in SDS-PAGE. ..
  22. Barreda Gómez G, Giralt M, Rodriguez Puertas R. G protein-coupled galanin receptor distribution in the rat central nervous system. Neuropeptides. 2005;39:153-6 pubmed
    ..These findings would suggest that the efficacy of galanin to induce an effective coupling of its receptors to G proteins could be different depending on the brain area. ..
  23. Pineau I, Barrette B, Vallières N, Lacroix S. A novel method for multiple labeling combining in situ hybridization with immunofluorescence. J Histochem Cytochem. 2006;54:1303-13 pubmed
    ..This new method will be particularly useful for investigators looking to identify cell populations producing mRNAs expressed in low abundance such as cytokines, chemokines, and growth factors in the intact and/or injured mammalian CNS. ..
  24. Traxler E, Bayer E, Stockl J, Mohr T, Lenz C, Gerner C. Towards a standardized human proteome database: quantitative proteome profiling of living cells. Proteomics. 2004;4:1314-23 pubmed
    ..While no significant alteration of protein amounts was detected at all upon activation, the synthesis rate of several proteins was found to be more than doubled. ..
  25. Gehlert D, Gackenheimer S, Shaw J. Distribution of nociceptin and Ro64-6198 activated [35S]-GTPgammaS binding in the rat brain. Neuropeptides. 2006;40:95-105 pubmed
    ..Using these techniques, we have demonstrated, for the first time that Ro64-6198 activates [(35)S]-GTPgammaS binding to rat brain sections and this compound stimulates a similar population of receptors as nociceptin. ..
  26. Arcanjo K, Belo G, Folco C, Werneck C, Borojevic R, Silva L. Biochemical characterization of heparan sulfate derived from murine hemopoietic stromal cell lines: a bone marrow-derived cell line S17 and a fetal liver-derived cell line AFT024. J Cell Biochem. 2002;87:160-72 pubmed
    ..35)S]-sulfated macromolecules could be released from the cell surface of both stromal cell lines by phosphatidylinositol phospholipase C (PI-PLC), which is consistent with the expression of glypican detected by PCR experiments. ..
  27. Madry H, Emkey G, Zurakowski D, Trippel S. Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an ex vivo model of articular chondrocyte transplantation. J Gene Med. 2004;6:238-45 pubmed
    ..These results suggest that therapeutic hFGF-2 gene transfer may be applicable for the treatment of articular cartilage disorders, such as traumatic defects in which cellular repopulation is a therapeutic goal. ..
  28. Wu Y, Buzzi A, Frantseva M, Velazquez J, Cortez M, Liu C, et al. Status epilepticus in mice deficient for succinate semialdehyde dehydrogenase: GABAA receptor-mediated mechanisms. Ann Neurol. 2006;59:42-52 pubmed
  29. Pacini S, Punzi T, Gulisano M, Cecchi F, Vannucchi S, Ruggiero M. Transdermal delivery of heparin using pulsed current iontophoresis. Pharm Res. 2006;23:114-20 pubmed
    ..We hypothesize that this technique could be used to administer low molecular weight heparin in a cost-efficient and safe manner without the need for syringes and needles. ..
  30. Lazarou M, McKenzie M, Ohtake A, Thorburn D, Ryan M. Analysis of the assembly profiles for mitochondrial- and nuclear-DNA-encoded subunits into complex I. Mol Cell Biol. 2007;27:4228-37 pubmed
    ..Subunit exchange may also act as an efficient mechanism to prevent the accumulation of oxidatively damaged subunits that would otherwise be detrimental to mitochondrial oxidative phosphorylation and have the potential to cause disease. ..
  31. Robador A, Brüchert V, Jørgensen B. The impact of temperature change on the activity and community composition of sulfate-reducing bacteria in arctic versus temperate marine sediments. Environ Microbiol. 2009;11:1692-703 pubmed publisher
    ..Conversely, in seasonally changing sediment sulfate reduction rates and sulfate-reducing bacterial abundance changed little in response to changing temperature. ..
  32. Dowling M, Nahorski S, Challiss R. Measurement of agonist-stimulated [35S]GTPgammaS binding to assess total G-protein and Galpha-subtype-specific activation by G-protein-coupled receptors. Methods Mol Biol. 2004;259:197-206 pubmed
    ..Here we describe a total [35S]GTPgammaS binding assay and a modification of this method that incorporates a Galpha-specific immunoprecipitation step. ..
  33. Veltman J, Podval J, Mattern J, Hall K, Lambert R, Edelhauser H. The disposition and bioavailability of 35S-GSH from 35S-GSSG in BSS PLUS in rabbit ocular tissues. J Ocul Pharmacol Ther. 2004;20:256-68 pubmed
    ..The data from this study demonstrate that 35S-GSSG in BSS PLUS is metabolized and taken up by ocular cells and that 35S-GSH becomes incorporated into the intracellular GSH pool of ocular tissues. ..
  34. Sanna E, Busonero F, Talani G, Mostallino M, Mura M, Pisu M, et al. Low tolerance and dependence liabilities of etizolam: molecular, functional, and pharmacological correlates. Eur J Pharmacol. 2005;519:31-42 pubmed
    ..These data suggest that etizolam is endowed with a reduced liability to induce tolerance and dependence compared with classical benzodiazepines. ..
  35. Heeg C, Kruse C, Jost R, Gutensohn M, Ruppert T, Wirtz M, et al. Analysis of the Arabidopsis O-acetylserine(thiol)lyase gene family demonstrates compartment-specific differences in the regulation of cysteine synthesis. Plant Cell. 2008;20:168-85 pubmed publisher
    ..Despite partial redundancy, the mitochondria and not the plastids play the most important role for Cys synthesis in Arabidopsis. ..
  36. Qian X, Moss N, Fellner R, Goy M. Circulating prouroguanylin is processed to its active natriuretic form exclusively within the renal tubules. Endocrinology. 2008;149:4499-509 pubmed publisher
    ..Thus, to respond to proUGn released from the gut, any target organ must use a local mechanism for production of active peptide. ..
  37. Ning B, Liu H, Gong W, Jiang J, Hu Y, Yang S. Biological characteristics of adult degenerative nucleus pulposus cells in a three-dimensional microcarrier stirring culture system. J Orthop Res. 2013;31:858-63 pubmed publisher
    ..05 and p < 0.01). In conclusion, the three-dimensional microcarrier stirring culture system provides a means of fast and massive propagation of NP seeding cells which maintain their normal physiological characteristics and functions. ..
  38. Newman Tancredi A, Cussac D, Marini L, Touzard M, Millan M. h5-HT(1B) receptor-mediated constitutive Galphai3-protein activation in stably transfected Chinese hamster ovary cells: an antibody capture assay reveals protean efficacy of 5-HT. Br J Pharmacol. 2003;138:1077-84 pubmed
  39. Inan S, Cowan A. Reduced kappa-opioid activity in a rat model of cholestasis. Eur J Pharmacol. 2005;518:182-6 pubmed
    ..56+/-0.09 and 3.29+/-0.22 ng/ml, respectively, P<0.01). We propose that pruritus in cholestasis may result from an impaired balance between mu- and kappa-opioid systems. ..
  40. Madrid V, Aller R, Aller J, Chistoserdov A. Evidence of the activity of dissimilatory sulfate-reducing prokaryotes in nonsulfidogenic tropical mobile muds. FEMS Microbiol Ecol. 2006;57:169-81 pubmed
    ..We propose a pathway of organic matter oxidation involving at least 5-25% of the remineralized carbon, wherein sulfide produced by sulfate-reducing prokaryotes is cyclically oxidized biotically or abiotically by metal oxides. ..
  41. Stafford Smith M, Bartz R, Wilson K, Baraniuk J, Schwinn D. Alpha-adrenergic mRNA subtype expression in the human nasal turbinate. Can J Anaesth. 2007;54:549-55 pubmed
  42. Eckert R. DNA sequencing by the chemical method. Curr Protoc Mol Biol. 2001;Chapter 7:Unit7.5 pubmed publisher
    ..Finally, the four reactions are subjected to electrophoresis on adjacent lanes of a high-resolution denaturing polyacrylamide gel. The gel is then autoradiographed and the sequence is read from the film. ..
  43. Bonifacino J. Metabolic labeling with amino acids. Curr Protoc Protein Sci. 2001;Chapter 3:Unit 3.7 pubmed publisher
  44. Engstrom M, Brandt A, Wurster S, Savola J, Panula P. Prolactin releasing peptide has high affinity and efficacy at neuropeptide FF2 receptors. J Pharmacol Exp Ther. 2003;305:825-32 pubmed
    ..The seemingly promiscuous binding of the RFamide peptides to the NPFF receptor was further confirmed by receptor autoradiography. PrRP may thus signal through the NPFF receptors in vivo. ..
  45. Sinkkonen S, Luscher B, Lüddens H, Korpi E. Autoradiographic imaging of altered synaptic alphabetagamma2 and extrasynaptic alphabeta GABAA receptors in a genetic mouse model of anxiety. Neurochem Int. 2004;44:539-47 pubmed
  46. Borges F, Michelacci Y, Aguiar J, Dalboni M, Garófalo A, Schor N. Characterization of glycosaminoglycans in tubular epithelial cells: calcium oxalate and oxalate ions effects. Kidney Int. 2005;68:1630-42 pubmed
    ..Tubular cells may increase the synthesis of glycosaminoglycans to protect from the toxic insult of calcium oxalate crystals and oxalate ions, what could partially limit the lithogenesis. ..
  47. Valdez M, Burke T, Hensler J. Selective heterologous regulation of 5-HT1A receptor-stimulated 35S GTPgammaS binding in the anterior cingulate cortex as a result of 5-HT2 receptor activation. Brain Res. 2002;957:174-82 pubmed
  48. Saidak Z, Blake Palmer K, Hay D, Northup J, Glass M. Differential activation of G-proteins by mu-opioid receptor agonists. Br J Pharmacol. 2006;147:671-80 pubmed
    ..These findings may provide a starting point for the design of drugs that demonstrate greater selectivity between these two G-proteins and therefore produce a more limited range of effects. ..
  49. Rajjou L, Belghazi M, Huguet R, Robin C, Moreau A, Job C, et al. Proteomic investigation of the effect of salicylic acid on Arabidopsis seed germination and establishment of early defense mechanisms. Plant Physiol. 2006;141:910-23 pubmed
    ..Finally, the proteomic data revealed a close interplay between abscisic signaling and SA elicitation of seed vigor. ..
  50. Oaknin S, Rodríguez Ferrer C, Ramos A, Aguilar J, Rotllán P. Binding of 5'-O-(2-thiodiphosphate) to rat brain membranes is prevented by diadenosine tetraphosphate and correlates with ecto-nucleotide pyrophosphatase phosphodiesterase 1 (NPP1) activity. Neurosci Lett. 2008;432:25-9 pubmed
  51. Son J, Winzer Serhan U. Signal intensities of radiolabeled cRNA probes used alone or in combination with non-isotopic in situ hybridization histochemistry. J Neurosci Methods. 2009;179:159-65 pubmed publisher
    ..Together, these results indicate that combined radioactive and non-radioactive DISH does not interfere with the detection of the radiation signal from the S35-labeled hybrids, and neither specificity nor sensitivity is compromised. ..
  52. Cooper T, McMurchie E, Leifert W. [35S]GTPgammaS binding in G protein-coupled receptor assays. Methods Mol Biol. 2009;552:143-51 pubmed publisher
    ..Agonist-stimulated [(35)S]GTPgammaS binding is measured in a 96-well plate format using scintillation counting. ..
  53. Ryan J, Harvey R, Metge D, Elimelech M, Navigato T, Pieper A. Field and laboratory investigations of inactivation of viruses (PRD1 and MS2) attached to iron oxide-coated quartz sand. Environ Sci Technol. 2002;36:2403-13 pubmed
    ..The actual rate of surface inactivation may be substantially underestimated owing to slow release of inactivated viruses...
  54. Urwyler S, Pozza M, Lingenhoehl K, Mosbacher J, Lampert C, Froestl W, et al. N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function. J Pharmacol Exp Ther. 2003;307:322-30 pubmed
    ..This effect is reversed by the competitive GABA(B) receptor antagonist CGP55845A and is produced most likely by enhancing the effect of synaptically released GABA at presynaptic GABA(B) receptors...
  55. Puppala B, Matwyshyn G, Bhalla S, Gulati A. Role of endothelin in neonatal morphine tolerance. J Cardiovasc Pharmacol. 2004;44 Suppl 1:S383-5 pubmed
    ..23%). This is the first report indicating the involvement of ET in neonatal morphine tolerance as evidenced by attenuation of ET-1-induced stimulation of GTP binding in neonatal rats tolerant to morphine...
  56. Biyashev D, Garadnay S, Marton J, Makleit S, Borsodi A, Benyhe S. Biochemical characterisation of newly developed beta-etorphine and beta-dihydroetorphine derivatives. Eur J Pharmacol. 2002;442:23-7 pubmed
    ..On the basis of our experimental results, neither the configuration of C18 nor the saturation of the C7-C8 double bond appears to play a critical role in the biological activity of etorphines...
  57. Pauwels P, Rauly I, Wurch T. Dissimilar pharmacological responses by a new series of imidazoline derivatives at precoupled and ligand-activated alpha 2A-adrenoceptor states: evidence for effector pathway-dependent differential antagonism. J Pharmacol Exp Ther. 2003;305:1015-23 pubmed
    ..In conclusion, these data demonstrate that certain alpha2 AR ligands that are assumed to be antagonists, may yield dissimilar pharmacological responses, dependent on the investigated agonist-stimulated effector pathway...
  58. Ko M, Lee H, Harrison C, Clark M, Song H, Naughton N, et al. Studies of micro-, kappa-, and delta-opioid receptor density and G protein activation in the cortex and thalamus of monkeys. J Pharmacol Exp Ther. 2003;306:179-86 pubmed
    ..In particular, the relative densities of opioid receptor binding sites in the two brain areas reflect their functional roles in the pharmacological actions of opioids in the central nervous system of primates...
  59. Narita M, Imai S, Ozaki S, Suzuki M, Narita M, Suzuki T. Reduced expression of a novel mu-opioid receptor (MOR) subtype MOR-1B in CXBK mice: implications of MOR-1B in the expression of MOR-mediated responses. Eur J Neurosci. 2003;18:3193-8 pubmed
  60. Zhu Q, Qi L, Shi A, Abou Samra A, Deth R. Protein kinase C regulates alpha(2A/D)-adrenoceptor constitutive activity. Pharmacology. 2004;71:80-90 pubmed
  61. Heydorn A, Ward R, Jorgensen R, Rosenkilde M, Frimurer T, Milligan G, et al. Identification of a novel site within G protein alpha subunits important for specificity of receptor-G protein interaction. Mol Pharmacol. 2004;66:250-9 pubmed
  62. Storstein A, Monstad S, Honnorat J, Vedeler C. Paraneoplastic antibodies detected by isoelectric focusing of cerebrospinal fluid and serum. J Neuroimmunol. 2004;155:150-4 pubmed
  63. Karamyshev A, Karamysheva Z, Yamami T, Ito K, Nakamura Y. Transient idling of posttermination ribosomes ready to reinitiate protein synthesis. Biochimie. 2004;86:933-8 pubmed
  64. Yamamoto C, Wakata T, Fujiwara Y, Kaji T. Induction of synthesis of a large heparan sulfate proteoglycan, perlecan, by thrombin in cultured human coronary smooth muscle cells. Biochim Biophys Acta. 2005;1722:92-102 pubmed
    ..The regulation of proteoglycan synthesis by thrombin may be involved in the accumulation of perlecan in advanced lesions of atherosclerosis...
  65. Coppi A, Cabinian M, Mirelman D, Sinnis P. Antimalarial activity of allicin, a biologically active compound from garlic cloves. Antimicrob Agents Chemother. 2006;50:1731-7 pubmed
    ..Together, these experiments demonstrate that the same cysteine protease inhibitor can target two different life cycle stages in the vertebrate host...
  66. Timmer N, van Horssen J, Otte Holler I, Wilhelmus M, David G, van Beers J, et al. Amyloid beta induces cellular relocalization and production of agrin and glypican-1. Brain Res. 2009;1260:38-46 pubmed publisher
    ..We conclude that Abeta can modulate the cellular expression of agrin and glypican-1, which may contribute to the accumulation of these HSPG in AD lesions...
  67. Gonzalez Maeso J, Rodriguez Puertas R, Meana J, García Sevilla J, Guimon J. Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha(2A)-adrenoceptors. Mol Psychiatry. 2002;7:755-67 pubmed
    ..The new finding provides functional support to the involvement of alpha(2)-adrenoceptors in the pathogenesis of mood disorders...
  68. White J, Wise A, Marshall F. Heterodimerization of gamma-aminobutyric acid B receptor subunits as revealed by the yeast two-hybrid system. Methods. 2002;27:301-10 pubmed
    ..Coexpression of the two seven-transmembrane proteins generated a fully functional receptor, which was expressed at the cell surface confirming the importance of receptor heterodimerization for GABA(B) receptor activity...
  69. Zhu Y, Conway Campbell B, Waters M, Dannies P. Prolonged retention after aggregation into secretory granules of human R183H-growth hormone (GH), a mutant that causes autosomal dominant GH deficiency type II. Endocrinology. 2002;143:4243-8 pubmed
    ..The longer retention of R183H-GH aggregates indicates that a single point mutation in a protein contained in secretory granules affects the rate of secretory granule release...
  70. Neu A, Neuhoff H, Trube G, Fehr S, Ullrich K, Roeper J, et al. Activation of GABA(A) receptors by guanidinoacetate: a novel pathophysiological mechanism. Neurobiol Dis. 2002;11:298-307 pubmed
    ..The interaction of GAA with neuronal GABA(A) receptors represents a candidate mechanism explaining neurological dysfunction in GAMT deficiency...
  71. Wentland M, Ye Y, Cioffi C, Lou R, Zhou Q, Xu G, et al. Syntheses and opioid receptor binding affinities of 8-amino-2,6-methano-3-benzazocines. J Med Chem. 2003;46:838-49 pubmed
    ..Several derivatives were shown to have intrinsic opioid-receptor-mediated activity in [(35)S]GTPgammaS assays...
  72. Kalra S, Li N, Seetharam S, Alpers D, Seetharam B. Function and stability of human transcobalamin II: role of intramolecular disulfide bonds C98-C291 and C147-C187. Am J Physiol Cell Physiol. 2003;285:C150-60 pubmed
    ..These studies suggest that optimal binding of Cbl by human TC II is supported by disulfide bonds C98-C291 and C147-C187 and that their disruption results in loss of Cbl binding and their rapid degradation by the proteasomal machinery...
  73. Hesse H, Trachsel N, Suter M, Kopriva S, von Ballmoos P, Rennenberg H, et al. Effect of glucose on assimilatory sulphate reduction in Arabidopsis thaliana roots. J Exp Bot. 2003;54:1701-9 pubmed
    ..Furthermore, signals originating from nitrogen and carbon metabolism regulate APR synergistically...
  74. Kowal D, Nawoschik S, Ochalski R, Dunlop J. Functional calcium coupling with the human metabotropic glutamate receptor subtypes 2 and 4 by stable co-expression with a calcium pathway facilitating G-protein chimera in Chinese hamster ovary cells. Biochem Pharmacol. 2003;66:785-90 pubmed
  75. Collins C, Cunningham N. Modelling the fate of sulphur-35 in crops. 1. Calibration data. Environ Pollut. 2005;133:431-7 pubmed
    ..There was no significant loss of radioactivity other than that expected from radioactive decay...
  76. Cao Y, Huang Y. Palmitoylation regulates GDP/GTP exchange of G protein by affecting the GTP-binding activity of Goalpha. Int J Biochem Cell Biol. 2005;37:637-44 pubmed
  77. Savijoki K, Suokko A, Palva A, Varmanen P. New convenient defined media for [(35)S]methionine labelling and proteomic analyses of probiotic lactobacilli. Lett Appl Microbiol. 2006;42:202-9 pubmed
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