selenium radioisotopes


Summary: Unstable isotopes of selenium that decay or disintegrate emitting radiation. Se atoms with atomic weights 70-73, 75, 79, 81, and 83-85 are radioactive selenium isotopes.

Top Publications

  1. Hu M, Viljoen A, Tappel A. Interactions of gold with cytosolic selenium-containing proteins in rat kidney and liver. J Inorg Biochem. 1988;32:281-90 pubmed
    ..This study demonstrates the interaction of Au with rat liver and kidney 75Se-containing proteins. ..
  2. Gladyshev V, Hatfield D. Analysis of selenocysteine-containing proteins. Curr Protoc Protein Sci. 2001;Chapter 3:Unit 3.8 pubmed publisher
    ..This unit provides an overview of known selenocysteine-containing proteins, examples of targeted incorporation of selenium into proteins, and methods specific for selenoprotein identification and characterization. ..
  3. Thorne M. Estimation of animal transfer factors for radioactive isotopes of iodine, technetium, selenium and uranium. J Environ Radioact. 2003;70:3-20 pubmed
    ..For each radionuclide considered, reference values and ranges of TF values are estimated. These are summarised in Table 1. ..
  4. Zinoni F, Heider J, Bock A. Features of the formate dehydrogenase mRNA necessary for decoding of the UGA codon as selenocysteine. Proc Natl Acad Sci U S A. 1990;87:4660-4 pubmed
    ..Translation of the UGA codon was found to occur with high fidelity since it was refractory to ribosomal mutations affecting proofreading and to suppression by the sup-9 gene product. ..
  5. Li C, Ko R, Moodie G, Kramer G. Evaluating the performance of the ORTEC® Detective™ for emergency urine bioassay. Radiat Prot Dosimetry. 2011;147:474-9 pubmed publisher
    ..30 requirements even at 10 % RL. At 1 % RL, (169)Yb and (192)Ir were not detectable at either geometry, while the measurement of (60)Co in the mixed radionuclides satisfied the ANSI N13.30 requirements only at the IG...
  6. Fassbender M, de Villiers D, Nortier M, van der Walt N. The natBr(p,x) (73,75)Se nuclear processes: a convenient route for the production of radioselenium tracers relevant to amino acid labelling. Appl Radiat Isot. 2001;54:905-13 pubmed
    ..4 MBq (2.2 mCi), and the calculated 75Se yield (EOB) for the overall range 62 MeV-->threshold for the same irradiation conditions is 0.97 MBq (0.026 mCi). ..
  7. Gharieb M, Gadd G. The kinetics of 75[Se]-selenite uptake by Saccharomyces cerevisiae and the vacuolization response to high concentrations. Mycol Res. 2004;108:1415-22 pubmed
    ..Transmission electron microscopy of 5 mM selenite-grown cells revealed the presence of abundant small cytoplasmic vesicles containing electron-dense granules which could represent an intracellular selenium-detoxification mechanism. ..
  8. Mykkanen H, Wasserman R. Uptake of 75Se-selenite by brush border membrane vesicles from chick duodenum stimulated by vitamin D. J Nutr. 1989;119:242-7 pubmed
    ..These data are compatible with the hypothesis that selenite easily crosses the brush border membrane into the intravesicular space and, once inside, is tightly bound by the membrane.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  9. Bryszewska M, Ambroziak W, Rudzinski J, Lewis D. Characterisation of selenium compounds in rye seedling biomass using 75Se-labelling/SDS-PAGE separation/gamma-scintillation counting, and HPLC-ICP-MS analysis of a range of enzymatic digests. Anal Bioanal Chem. 2005;382:1279-87 pubmed

More Information


  1. Lanzini A, De Tavonatti M, Panarotto B, Scalia S, Mora A, Benini F, et al. Intestinal absorption of the bile acid analogue 75Se-homocholic acid-taurine is increased in primary biliary cirrhosis, and reverts to normal during ursodeoxycholic acid administration. Gut. 2003;52:1371-5 pubmed
    ..Our results support the concept that ileal bile acid absorption is upregulated in PBC patients, and that this effect may contribute towards damaging the cholestatic liver. This upregulation of bile acid absorption is abolished by UDCA. ..
  2. Borghede M, Schlütter J, Agnholt J, Christensen L, Gormsen L, Dahlerup J. Bile acid malabsorption investigated by selenium-75-homocholic acid taurine ((75)SeHCAT) scans: causes and treatment responses to cholestyramine in 298 patients with chronic watery diarrhoea. Eur J Intern Med. 2011;22:e137-40 pubmed publisher
    ..Bile acid malabsorption is a frequent problem in patients with chronic watery diarrhoea. Treatment with bile acid binders was effective regardless of type and severity. ..
  3. Deiner C, Shagdarsuren E, Schwimmbeck P, Rosenthal P, Loddenkemper C, Rauch U, et al. Nf-kappab and AP-1 activation is associated with late lumen loss after porcine coronary angioplasty and antiproliferative beta-irradiation. Cardiovasc Res. 2007;75:195-204 pubmed
    ..g. activation of NF-kappaB) are enhanced within the arterial wall. This proinflammatory side effect may be responsible for the observed delayed proliferation and the resulting lumen loss. ..
  4. Pérez Sánchez D, Thorne M, Limer L. A mathematical model for the behaviour of Se-79 in soils and plants that takes account of seasonal variations in soil hydrology. J Radiol Prot. 2012;32:11-37 pubmed publisher
  5. Whanger P. Selenoprotein W. Methods Enzymol. 2002;347:179-87 pubmed
  6. Färkkilä M, Kairemo K, Taavitsainen M, Strandberg T, Miettinen T. Plasma lathosterol as a screening test for bile acid malabsorption due to ileal resection: correlation with 75SeHCAT test and faecal bile acid excretion. Clin Sci (Lond). 1996;90:315-9 pubmed
    ..4. The results indicate that both the 75SeHCAT test and plasma lathosterol detect bile acid malabsorption in patients with ileal resections for Crohn's disease. However, plasma lathosterol is a simpler and less expensive method. ..
  7. Navarrete M, Gaudry A, Revel G, Martinez T, Cabrera L. Urinary selenium excretion in patients with cervical uterine cancer. Biol Trace Elem Res. 2001;79:97-105 pubmed
    ..These results show a statistically significant increase of selenium excretion in cancer patients as compared to controls. Urinary selenium excretion is highest for patients in the intermediate stages of the disease. ..
  8. Petrovich Y, Podorozhnaya R, Kichenko S. A method for evaluating the fluctuations in the intensity of substance transport between blood and bones in the predominant direction. Bull Exp Biol Med. 2006;142:637-42 pubmed
    ..The technology of calculating this coefficient is described. ..
  9. Xu X, Carlson B, Grimm T, Kutza J, Berry M, Arreola R, et al. Rhesus monkey simian immunodeficiency virus infection as a model for assessing the role of selenium in AIDS. J Acquir Immune Defic Syndr. 2002;31:453-63 pubmed
  10. Mykkanen H, Wasserman R. Relationship of membrane-bound sulfhydryl groups to vitamin D-stimulated uptake of [75Se]Selenite by the brush border membrane vesicles from chick duodenum. J Nutr. 1990;120:882-8 pubmed
    ..A significant increase in selenite uptake by intravenous 1,25-dihydroxycholecalciferol occurred within 10 min. This rapid effect provides a new tool to probe early biochemical effects of vitamin D on intestinal epithelium. ..
  11. Taylor D. Generic models for radionuclide dosimetry: 11C-, 18F- or 75Se-labelled amino acids. Appl Radiat Isot. 2000;52:911-22 pubmed
    ..It was concluded that for 11C- and 18F-labelled amino acids and for 75Se-labelled amino acids or their analogues, the single generic biokinetic model could be applied for general radiation protection purposes. ..
  12. Davidson W, McMurray C. 75Selenium-labeled sheep plasma: the time course of changes in 75selenium distribution. J Inorg Biochem. 1988;34:1-9 pubmed
    ..No difference in the stability between selenite- and selenocystine-labeled plasma could be detected...
  13. Ballaux C. Gamma radiography with 75Se sources: consequences of a violent fire. Health Phys. 2000;78:311-5 pubmed
    ..If this is not the case, x-ray equipment and 192Ir sources have to be preferred above 75Se sources. ..
  14. Notta P, Ramal D, Maisterra S, Rodríguez Gasén A, Maymó S, Sabate A, et al. [Measurement of 75Se-SeHCAT abdominal retention in the initial diagnosis of Bile Acid Absorption (BAM)]. Rev Esp Med Nucl. 2011;30:297-300 pubmed publisher
    ..The measurement of (75)SEHCAT abdominal retention allows the early diagnosis of bile acid malabsorption in 43% of the patients with DS. Measurement at 7 days seems more accurate than that at 4 days. ..
  15. Hurtevent P, Thiry Y, Levchuk S, Yoschenko V, Henner P, Madoz Escande C, et al. Translocation of 125I, 75Se and 36Cl to wheat edible parts following wet foliar contamination under field conditions. J Environ Radioact. 2013;121:43-54 pubmed publisher
    ..This study was therefore able to obtain accurate translocation factors, which are probably among the highest that could be recorded. ..
  16. Ashworth D, Shaw G. Soil migration, plant uptake and volatilisation of radio-selenium from a contaminated water table. Sci Total Environ. 2006;370:506-14 pubmed
    ..Quantification of (75)Se volatilisation from the column surfaces suggested that this is a significant pathway by which (79)Se may move either directly from soil to the atmosphere, or from soil to plants and then to the atmosphere. ..
  17. Wycoff D, Gott M, Degraffenreid A, Morrow R, Sisay N, Embree M, et al. Chromatographic separation of selenium and arsenic: A potential (72)Se/(72)As generator. J Chromatogr A. 2014;1340:109-14 pubmed publisher
    ..At pH 1.5, selenate is retained on strongly basic anion exchange resin as HSeO4(-) and SeO4(2-), while neutral arsenic acid, H3AsO4, is eluted. ..
  18. Godin S, Bouzas Ramos D, Fontagné Dicharry S, Bouyssiere B, Bueno M. Deproteinization assessment using isotopically enriched compounds to trace the coprecipitation of low-molecular-weight selenium species with proteins. Anal Biochem. 2017;530:9-16 pubmed publisher
    ..This successfully applied strategy is anticipated to be useful for more extensive future studies in selenometabolomics. ..
  19. Gladyshev V, Jeang K, Wootton J, Hatfield D. A new human selenium-containing protein. Purification, characterization, and cDNA sequence. J Biol Chem. 1998;273:8910-5 pubmed
    ..The discovery of a new human selenoprotein provides an additional example of the role of selenium in mammalian systems. ..
  20. Leinfelder W, Stadtman T, Bock A. Occurrence in vivo of selenocysteyl-tRNA(SERUCA) in Escherichia coli. Effect of sel mutations. J Biol Chem. 1989;264:9720-3 pubmed
    ..The formation of selenocysteine depended on the presence of functional products of the selA and selD genes but not of the selB gene. The selB gene product, therefore, may have a function in the decoding step itself. ..
  21. Hara S, Shoji Y, Sakurai A, Yuasa K, Himeno S, Imura N. Effects of selenium deficiency on expression of selenoproteins in bovine arterial endothelial cells. Biol Pharm Bull. 2001;24:754-9 pubmed
  22. Tariq M, Preiss I. [75Se]selenite and [75Se]selenate fluctuations during the development of murine hepatoma. Int J Rad Appl Instrum B. 1992;19:555-61 pubmed
    ..These changes are prominent in the early growth phase of the tumor. The two oxidation states show differences in the TEP for kidney, spleen, stomach and testes. ..
  23. Berry M, Martin G, Tujebajeva R, Grundner Culemann E, Mansell J, Morozova N, et al. Selenocysteine insertion sequence element characterization and selenoprotein expression. Methods Enzymol. 2002;347:17-24 pubmed
  24. Koch Steindl H, Pröhl G. Considerations on the behavior of long-lived radionuclides in the soil. Radiat Environ Biophys. 2001;40:93-104 pubmed
    ..Against this background, present-day parameters may in general be considered appropriate for roughly estimating the behaviour of radionuclides in the soil-plant system. ..
  25. Curcio Morelli C, Gereben B, Zavacki A, Kim B, Huang S, Harney J, et al. In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases. Endocrinology. 2003;144:937-46 pubmed
  26. Reschini E, Catania A. Clinical experience with the adrenal scanning agents iodine 131-19-iodocholesterol and selenium 75-6-selenomethylcholesterol. Eur J Nucl Med. 1991;18:817-23 pubmed
  27. Cramp M, Hing M, Marriott D, Freund J, Cooper D. Bile acid malabsorption in HIV infected patients with chronic diarrhoea. Aust N Z J Med. 1996;26:368-71 pubmed
    ..To look for the presence of bile acid malabsorption in HIV infected patients with chronic diarrhoea and determine whether bile sequestering agents may have a role in palliating this common problem...
  28. Castellano S, Morozova N, Morey M, Berry M, Serras F, Corominas M, et al. In silico identification of novel selenoproteins in the Drosophila melanogaster genome. EMBO Rep. 2001;2:697-702 pubmed
    ..One of them belongs to a known family of selenoproteins, and we have tested experimentally two other predictions with positive results. Finally, we have characterized the expression pattern of these two novel selenoprotein genes...
  29. Golczewski J, Frenkel G. Cellular selenoproteins and the effects of selenite on cell proliferation. Biol Trace Elem Res. 1989;20:115-26 pubmed
    ..They further confirm that selenium can have a slight stimulatory effect on cell growth, and a much larger inhibitory effect, depending on its concentration...
  30. Petrovich I, Kosenko K, Podorozhnaia R, Kichenko S. [Effect of cariesogenic diet and age on selenium distribution between blood and mineralized tissues in rats]. Stomatologiia (Mosk). 2004;83:4-8 pubmed
    ..In one-month-old rats receiving sucrose-casein diet during 2 months all RRA and SA after 6 and 12 h and part of RRA after 24 h were higher than in the control, that is, Se absorption by bones and teeth from the blood decreased...
  31. Lalitha K, Kulothungan S. Mimosine mitigates oxidative stress in selenium deficient seedlings of Vigna radiata. Part II: mitochondrial uptake of 75selenium and mimosine. Biol Trace Elem Res. 2007;118:269-86 pubmed
    ..Evidence presented for mimosine mediated increase in mitochondrial Se uptake and cooperative interactions thereof underscores the metabolic significance of mimosine...
  32. Obata T, Araie H, Shiraiwa Y. Bioconcentration mechanism of selenium by a coccolithophorid, Emiliania huxleyi. Plant Cell Physiol. 2004;45:1434-41 pubmed
    ..huxleyi rapidly absorbs selenite, filling a small intracellular pool. Then, Se-containing LMCs are immediately synthesized from the selenite, creating a pool of LMCs that are then metabolized to selenoproteins...
  33. Colinon Dupuich C, Février L, Ranjard L, Coppin F, Cournoyer B, Nazaret S. Radioecological risk assessment of low selenium concentrations through genetic fingerprints and metabolic profiling of soil bacterial communities. Microb Ecol. 2011;62:14-24 pubmed publisher
  34. Schoenmakers C, Pigmans I, Poland A, Visser T. Impairment of the selenoenzyme type I iodothyronine deiodinase in C3H/He mice. Endocrinology. 1993;132:357-61 pubmed
    ..We conclude that in mice, like in rats and humans, ID-I is a selenoprotein. ID-I activity is impaired in C3H mice because of decreased transcription of the ID-I gene or reduced stability of the mRNA...
  35. Guan R, Wang W. Dietary assimilation and elimination of Cd, Se, and Zn by Daphnia magna at different metal concentrations. Environ Toxicol Chem. 2004;23:2689-98 pubmed
    ..The change of TTF with metal concentration will have important implication for ecotoxicity testing using D. magna, especially when the dietary exposure is incorporated...
  36. Petrovich Y, Podorozhnaya R, Kichenko S. A new method for evaluation of radioactive label transport intensity in the predominant direction between blood and liver. Bull Exp Biol Med. 2005;140:102-5 pubmed
    ..Coefficient of difference in 1-month-old rats was characterized by a greater amplitude of fluctuations than in 3-month-old animals...
  37. Wang X, Liu X. Sorption and desorption of radioselenium on calcareous soil and its solid components studied by batch and column experiments. Appl Radiat Isot. 2005;62:1-9 pubmed
    ..The breakthrough curves (BTCs) can be simulated by a one-dimensional convection-dispersion transport model...
  38. Ung K, Kilander A, Nilsson O, Abrahamsson H. Long-term course in collagenous colitis and the impact of bile acid malabsorption and bile acid sequestrants on histopathology and clinical features. Scand J Gastroenterol. 2001;36:601-9 pubmed
    ..The aim was to study whether bile acid malabsorption is a permanent finding, with an impact on histopathology and clinical features in collagenous colitis...
  39. Ashworth D, Moore J, Shaw G. Effects of soil type, moisture content, redox potential and methyl bromide fumigation on Kd values of radio-selenium in soil. J Environ Radioact. 2008;99:1136-42 pubmed publisher
    ..The inter-relations between soil moisture content, redox potential and Se speciation should be considered in the modelling and assessment of radioactive Se fate and transport in the environment...
  40. Kuhbacher M, Bartel J, Hoppe B, Alber D, Bukalis G, Bräuer A, et al. The brain selenoproteome: priorities in the hierarchy and different levels of selenium homeostasis in the brain of selenium-deficient rats. J Neurochem. 2009;110:133-42 pubmed publisher
    ..A brain region-specific uptake pattern of the radiotracer (75)Se in selenium-deficient rats could be revealed and the CSF was identified as a key part of the brain selenium homeostasis...
  41. Albrecht A, Miquel S. Extension of sensitivity and uncertainty analysis for long term dose assessment of high level nuclear waste disposal sites to uncertainties in the human behaviour. J Environ Radioact. 2010;101:55-67 pubmed publisher
    ..The probabilistic approach can furthermore be used to construct critical groups based on a predefined probability level and to ensure that critical groups cover the expected range of uncertainty...
  42. Jenkins K, Hidiroglou M. Binding of selenium-75 to blood and liver cytosolic proteins in the preruminant calf. J Dairy Sci. 1988;71:442-51 pubmed
  43. Loffredo N, Mounier S, Thiry Y, Coppin F. Sorption of selenate on soils and pure phases: kinetic parameters and stabilisation. J Environ Radioact. 2011;102:843-51 pubmed publisher
    ..Thus, this work shows that the comparison of selenate behaviour between soil and pure phases helps to elucidate the main carrier phases and sorption mechanisms in soil...
  44. Viljoen A, Motchnik P, Tappel A. Selenium-containing proteins of rat kidney and liver microsomes. J Inorg Biochem. 1989;37:295-308 pubmed
    ..The results support the hypothesis that there is a mechanism for transfer of Se from the 55 kDa subunit to other Se-containing proteins...
  45. Bienvenu P, Cassette P, Andreoletti G, Bé M, Comte J, Lépy M. A new determination of 79Se half-life. Appl Radiat Isot. 2007;65:355-64 pubmed
    ..The activity was measured using LSC after gamma-ray spectrometry to check the contribution of residual radioactive contaminants. From these results, the half-life of (79)Se was found to be 3.77 (19) x 10(5) a...
  46. Ramli K, Abdullah B, Ng K, Mahmud R, Hussain A. Computed and conventional chest radiography: a comparison of image quality and radiation dose. Australas Radiol. 2005;49:460-6 pubmed
    ..The patients' mean ESD for chest radiography using the storage phosphor, film-screen combination and selenium drum was 0.20, 0.20 and 0.25 mGy, respectively, with no statistically significant difference with P > 0.05 (chi(2) tests)...
  47. Johansson L, Svensson L, Bergstrom U, Jacobsson Ekman G, Arner E, van Hage M, et al. A mouse model for in vivo tracking of the major dust mite allergen Der p 2 after inhalation. FEBS J. 2005;272:3449-60 pubmed
    ..Thus, an allergic response to the inhaled allergen may lead to prolonged retention of Der p 2 in the lung...
  48. Talbot S, Nelson R, Self W. Arsenic trioxide and auranofin inhibit selenoprotein synthesis: implications for chemotherapy for acute promyelocytic leukaemia. Br J Pharmacol. 2008;154:940-8 pubmed publisher
    ..The effect of inhibitors of TrxR on selenium metabolism has yet to be assessed. This study aims to determine whether chemotherapeutics that target selenocysteine within selenoenzymes may also affect the metabolism of selenium...
  49. Gil García C, Tagami K, Uchida S, Rigol A, Vidal M. New best estimates for radionuclide solid-liquid distribution coefficients in soils. Part 3: miscellany of radionuclides (Cd, Co, Ni, Zn, I, Se, Sb, Pu, Am, and others). J Environ Radioact. 2009;100:704-15 pubmed publisher
    ..Although there are still gaps for many radionuclides, new data from recent studies improve the calculation of K(d) best estimates for a number of radionuclides, such as selenium, antimony, and iodine...
  50. Conley J, Funk D, Buchwalter D. Selenium bioaccumulation and maternal transfer in the mayfly Centroptilum triangulifer in a life-cycle, periphyton-biofilm trophic assay. Environ Sci Technol. 2009;43:7952-7 pubmed publisher
  51. H Currier B, Munro J, Medich D. Selection of an appropriate air kerma rate constant for 75Se sources. Health Phys. 2013;104:511-6 pubmed publisher
  52. Lumachi F, Zucchetta P, Marzola M, Bui F, Casarrubea G, Angelini F, et al. Usefulness of CT scan, MRI and radiocholesterol scintigraphy for adrenal imaging in Cushing's syndrome. Nucl Med Commun. 2002;23:469-73 pubmed
    ..The sensitivity and specificity of CT scan and MRI are similar, but the latter shows a lower accuracy, especially in patients with bilateral adrenal involvement...
  53. Shepherdley C, Klootwijk W, Makabe K, Visser T, Kuiper G. An ascidian homolog of vertebrate iodothyronine deiodinases. Endocrinology. 2004;145:1255-68 pubmed
    ..This raises the hypothesis that, in protochordates, the prohormone T(4) is activated by enzymatic outer-ring deiodination to T(3)...
  54. Frenkel G, Falvey D, MacVicar C. Products of the reaction of selenite with intracellular sulfhydryl compounds. Biol Trace Elem Res. 1991;30:9-18 pubmed
    ..The same species were detected when [75Se]selenite was added to the acid-soluble fraction of a cell extract (as opposed to living cells), confirming that these compounds can be formed by nonenzymatic reactions...
  55. Morrison D, Medina D. Time course of selenite metabolism in confluent cultures of mouse mammary epithelial cells. Chem Biol Interact. 1989;71:177-86 pubmed
    ..The time period of increasing inhibition of DNA synthesis correlated with increasing levels of selenoproteins. The major selenoprotein found in this time frame in confluent phase LMA cells was an acidic, 58K selenoprotein...
  56. Younis J, Bercovici B, Zlotogorski A, Horne T, Glaser B. Lipid cell tumor of the ovary: steroid hormone secretory pattern and localization using 75Se-selenomethylcholesterol. Gynecol Obstet Invest. 1989;27:110-2 pubmed
    ..Localization was accomplished noninvasively using 75Se-selenomethylcholesterol. Peripheral and ovarian vein steroid concentrations suggest that the tumor produced androgens preferentially by way of the delta 4 steroidogenesis pathway...
  57. Even Sapir E, Keidar Z, Sachs J, Engel A, Bettman L, Gaitini D, et al. The new technology of combined transmission and emission tomography in evaluation of endocrine neoplasms. J Nucl Med. 2001;42:998-1004 pubmed
    ..The clinical value of a novel technology of combined transmission and emission tomography (TET) was assessed in patients with endocrine tumors...
  58. Kyriakopoulos A, Bertelsmann H, Graebert A, Hoppe B, Kuhbacher M, Behne D. Detection and characterization of membrane-bound selenoproteins in the kidney of the rat. Ann N Y Acad Sci. 2002;973:289-92 pubmed
    ..In this way, in addition to already known membrane-bound selenoproteins three novel selenoproteins in the molecular mass range of 38-40, 18, and 12-13 kDa were detected in the microsomal membranes...
  59. Gailer J, George G, Harris H, Pickering I, Prince R, Somogyi A, et al. Synthesis, purification, and structural characterization of the dimethyldiselenoarsinate anion. Inorg Chem. 2002;41:5426-32 pubmed
    ..943 A and two As-Se interactions at 2.279 A. On the basis of these results this novel solution species is identified as the dimethyldiselenoarsinate anion...
  60. Ung K, Kilander A, Willen R, Abrahamsson H. Role of bile acids in lymphocytic colitis. Hepatogastroenterology. 2002;49:432-7 pubmed
    ..A high prevalence of bile acid malabsorption and a high response rate to bile acid binders are seen in collagenous colitis. Our aim was to explore if bile acids play a role in lymphocytic colitis, which is unknown...
  61. Jalilian A, Rowshanfarzad P, Afarideh H, Shafiee A, Sabet M, Kyoumarsi M, et al. Synthesis of [75Se]5-ethoxycarbonyl-4-methyl-1,2,3-selenadiazole. Appl Radiat Isot. 2004;60:659-63 pubmed
    ..Column chromatography of the final solution afforded the desired labeled compound in 30% yield and greater than 98% radiochemical purity...
  62. Siddiqui A, Lei Y, Fusco A, Salafsky B. Radiolabeling of Necator americanus third stage larvae with 75Se-methionine. Parasitol Res. 1990;76:722-3 pubmed
    ..All of the label was decayed in 5 days from larvae labeled in aqueous cultures, whereas appreciable amounts of radioactivity were still detectable at day 7 of chase period in coproculture labeled larvae...
  63. Mas A, Sarkar B. Role of glutathione in selenite binding by human plasma. Biol Trace Elem Res. 1989;20:95-104 pubmed
    ..A saturable low molecular weight compound is also able to bind selenium, which may be relevant in the initial distribution and excretion of selenium after selenite administration...
  64. Tamura T, Sato K, Komori K, Imai T, Kuwahara M, Okugochi T, et al. Selenite reduction by the thioredoxin system: kinetics and identification of protein-bound selenide. Biosci Biotechnol Biochem. 2011;75:1184-7 pubmed
    ..The protein-bound selenium has metabolic significance in being stabilized in the divalent state, and it also produced the selenopersulfide (-S-SeH) form by the catalysis of E. coli trx reductase (TrxB)...
  65. Viljoen A, Tappel A. Selenium-containing proteins of rat kidney. J Inorg Biochem. 1988;33:263-75 pubmed
    ..Injection of animals with 75Se is the method of choice for isotopic labeling of rat kidney Se-containing proteins. Appropriate methods were developed that can be used in future studies of kidney Se-containing proteins...
  66. Veres Z, Stadtman T. A purified selenophosphate-dependent enzyme from Salmonella typhimurium catalyzes the replacement of sulfur in 2-thiouridine residues in tRNAs with selenium. Proc Natl Acad Sci U S A. 1994;91:8092-6 pubmed
    ..A labeled compound in the nucleoside mixture was coeluted with authentic 5-methylaminomethyl-2-selenouridine...
  67. Gregianin M, Bui F, Varotto L, Zucchetta P, Macri C. [Nuclear medicine methods for the diagnosis of adrenal tumors]. Minerva Endocrinol. 1995;20:27-38 pubmed
    ..This method has a high overall sensitivity and specificity. Lastly, MIBG scintigraphy is useful in the study of neuroblastoma...
  68. Gladyshev V, Krause M, Xu X, Korotkov K, Kryukov G, Sun Q, et al. Selenocysteine-containing thioredoxin reductase in C. elegans. Biochem Biophys Res Commun. 1999;259:244-9 pubmed
    ..The data show that TR-Se is the major naturally occurring selenoprotein in C. elegans, and suggest an important role for selenium and the thioredoxin system in this organism...
  69. Gregus Z, Gyurasics A, Csanaky I. Effects of arsenic-, platinum-, and gold-containing drugs on the disposition of exogenous selenium in rats. Toxicol Sci. 2000;57:22-31 pubmed
    ..Furthermore, the capability of TMA and MAP to enhance the biliary and total excretion of selenium renders these drugs significant candidates for antidotes in selenium intoxication...
  70. Tujebajeva R, Ransom D, Harney J, Berry M. Expression and characterization of nonmammalian selenoprotein P in the zebrafish, Danio rerio. Genes Cells. 2000;5:897-903 pubmed
    ..Selenoprotein P genes have, to date, only been reported in mammals, and the function of the protein remains elusive...
  71. Tagmount A, Berken A, Terry N. An essential role of s-adenosyl-L-methionine:L-methionine s-methyltransferase in selenium volatilization by plants. Methylation of selenomethionine to selenium-methyl-L-selenium- methionine, the precursor of volatile selenium. Plant Physiol. 2002;130:847-56 pubmed
    ..Thus, our results provide in vivo evidence that MMT is the key enzyme catalyzing the methylation of Se-Met to SeMM...
  72. González Iglesias H, Fernández Sánchez M, Garcia Alonso J, Sanz Medel A. Use of enriched 74Se and 77Se in combination with isotope pattern deconvolution to differentiate and determine endogenous and supplemented selenium in lactating rats. Anal Bioanal Chem. 2007;389:707-13 pubmed
    ..The obtained results are discussed in terms of selenium exchange and half-life in lactating rats (11-12 days) and selenium levels in serum in comparison with non-supplemented rats and control rats after maternal feeding...
  73. Barzon L, Fallo F, Sonino N, Boscaro M. Overnight dexamethasone suppression of cortisol is associated with radiocholesterol uptake patterns in adrenal incidentalomas. Eur J Endocrinol. 2001;145:223-4 pubmed
  74. Bukalis K, Alber D, Bukalis G, Behne D, Kyriakopoulos A. Effects of selenium diet on expression of selenoproteins in the lung of the rat. Ann N Y Acad Sci. 2007;1095:467-72 pubmed
    ..The differences in the specific incorporation of the element in the selenium deficiency into different compounds suggested that there are different metabolic pathways for selenium, strongly dependent on its status...
  75. Suzuki K, Ishiwata K, Ogra Y. Incorporation of selenium into selenoprotein P and extracellular glutathione peroxidase: HPLC-ICPMS data with enriched selenite. Analyst. 1999;124:1749-53 pubmed
  76. Tiwary A, Stegelmeier B, Panter K, James L, Hall J. Comparative toxicosis of sodium selenite and selenomethionine in lambs. J Vet Diagn Invest. 2006;18:61-70 pubmed
    ..Results of this study indicate that the chemical form of the ingested Se must be known to adequately interpret tissue, blood, and serum Se concentrations...
  77. Lescure A, Gautheret D, Krol A. Novel selenoproteins identified from genomic sequence data. Methods Enzymol. 2002;347:57-70 pubmed
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    ..At least two proteins, one albumin like, probably albumin itself and the other of molecular weight close to or greater than 200,000 in the plasma, are involved in the binding and efflux processes...
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