radioactive tracers


Summary: Radioactive substances added in minute amounts to the reacting elements or compounds in a chemical process and traced through the process by appropriate detection methods, e.g., Geiger counter. Compounds containing tracers are often said to be tagged or labeled. (Hawley's Condensed Chemical Dictionary, 12th ed)

Top Publications

  1. King M, Pretorius P, Farncombe T, Beekman F. Introduction to the physics of molecular imaging with radioactive tracers in small animals. J Cell Biochem Suppl. 2002;39:221-30 pubmed
    Recent advances have greatly enhanced the three-dimensional (3D) imaging of radioactive tracers in living animals. this article introduces the physics of imaging behind the imaging methods...
  2. Eckelman W, Reba R, Kelloff G. Targeted imaging: an important biomarker for understanding disease progression in the era of personalized medicine. Drug Discov Today. 2008;13:748-59 pubmed publisher
    ..Such an imaging agent developed in concert with drug development has a built in synergy that will accelerate the drug development process, targeted imaging and personalized medicine as well...
  3. Zeng C, Du Y, Alberico T, Seeberger J, Sun X, Zou S. Gender-specific prandial response to dietary restriction and oxidative stress in Drosophila melanogaster. Fly (Austin). 2011;5:174-80 pubmed
    ..This study describes an accurate method to measure food intake and provides a basis to further investigate prandial response to DR and prolongevity interventions in invertebrates...
  4. Tateishi U, Oka T, Inoue T. Radiolabeled RGD peptides as integrin alpha(v)beta3-targeted PET tracers. Curr Med Chem. 2012;19:3301-9 pubmed
    ..Many linear or cyclic RGD peptides were developed for positron emission tomography (PET). In this review, we focused on currently developed RGD peptides as PET probes for non-invasive detection of integrin alpha(v)beta3 expression. ..
  5. Tichauer K, Samkoe K, Klubben W, Hasan T, Pogue B. Advantages of a dual-tracer model over reference tissue models for binding potential measurement in tumors. Phys Med Biol. 2012;57:6647-59 pubmed publisher
    ..23% ± 9.07%). These findings highlight the potential for using a dual-tracer approach to quantify receptor expression in tumors with abnormal hemodynamics, possibly to inform the choice or progress of molecular cancer therapies...
  6. Kleiter M, Yu D, Mohammadian L, Niehaus N, Spasojevic I, Sanders L, et al. A tracer dose of technetium-99m-labeled liposomes can estimate the effect of hyperthermia on intratumoral doxil extravasation. Clin Cancer Res. 2006;12:6800-7 pubmed
    ..The purpose of this study was to determine if a small tracer dose of technetium-99m (99mTc)-labeled liposomes could be used to quantify the effect of local hyperthermia on intratumoral Doxil extravasation...
  7. Haubner R, Wester H. Radiolabeled tracers for imaging of tumor angiogenesis and evaluation of anti-angiogenic therapies. Curr Pharm Des. 2004;10:1439-55 pubmed
    ..Further studies have to demonstrate that this approach can be translated to clinical settings allowing visualisation of alpha v beta 3-positive tumours and alpha v beta 3 expression during tumour-induced angiogenesis in patients...
  8. Yelgaonkar V, Jayakumar T, Singh S, Sharma M. Combination of sealed source and radiotracer technique to understand malfunctioning in a chemical plant. Appl Radiat Isot. 2009;67:1244-7 pubmed publisher
    ..It indicated that the flow is decelerated in the heat exchanger because of the presence of vapour lock in the tube side. ..
  9. Ma Y, Lang L, Reyes L, Tokugawa J, Jagoda E, Kiesewetter D. Application of highly sensitive UPLC-MS to determine biodistribution at tracer doses: validation with the 5-HT1A ligand [(18)F]FPWAY. Nucl Med Biol. 2009;36:389-93 pubmed publisher
    ..This concordance indicated that high-sensitivity LC/MS is an indispensable tool in evaluating the quantity of administered chemical in tissue as part of the development of new molecular imaging probes. ..

More Information

Publications111 found, 100 shown here

  1. Rbah Vidal L, Vidal A, Besse S, Cachin F, Bonnet M, Audin L, et al. Early detection and longitudinal monitoring of experimental primary and disseminated melanoma using [¹?F]ICF01006, a highly promising melanoma PET tracer. Eur J Nucl Med Mol Imaging. 2012;39:1449-61 pubmed publisher
    ..Our promising results provide further preclinical data, reinforcing the excellent potential of [(18)F]ICF01006 PET imaging for early specific diagnosis and follow-up of melanin-positive disseminated melanoma. ..
  2. Moncayo V, Aarsvold J, Grant S, Bartley S, Alazraki N. Status of sentinel lymph node for breast cancer. Semin Nucl Med. 2013;43:281-93 pubmed publisher
    ..The proper Current Procedural Terminology (CPT) code for lymphoscintigraphy and SLN localization prior to surgery is 78195. ..
  3. Bühler J, Huber G, Schmid F, Blümler P. Analytical model for long-distance tracer-transport in plants. J Theor Biol. 2011;270:70-9 pubmed publisher
    ..This is demonstrated for PET data sets obtained from radish, sugar beet and maize plants. ..
  4. Guo N, Lang L, Li W, Kiesewetter D, Gao H, Niu G, et al. Quantitative analysis and comparison study of [18F]AlF-NOTA-PRGD2, [18F]FPPRGD2 and [68Ga]Ga-NOTA-PRGD2 using a reference tissue model. PLoS ONE. 2012;7:e37506 pubmed publisher
  5. Weiss M. A model for transit time distributions through organs that accounts for fractal heterogeneity. J Theor Biol. 2012;301:57-61 pubmed
    ..It has been fitted to outflow data from the rabbit heart and rat liver. The power-law decay with exponent -3 observed in the heart, corresponds to an intra-organ flow distribution with a relative dispersion of about 35%. ..
  6. Wållberg H, Ståhl S. Design and evaluation of radiolabeled tracers for tumor imaging. Biotechnol Appl Biochem. 2013;60:365-83 pubmed publisher
    ..Additionally, we describe important biotechnological considerations and desired features when designing and developing tracers for radionuclide molecular imaging. ..
  7. Razavian M, Tavakoli S, Zhang J, Nie L, Dobrucki L, Sinusas A, et al. Atherosclerosis plaque heterogeneity and response to therapy detected by in vivo molecular imaging of matrix metalloproteinase activation. J Nucl Med. 2011;52:1795-802 pubmed publisher
    ..Molecular imaging of MMP activation reveals the heterogeneity of atherosclerotic plaques and is a useful tool for tracking plaque biology and response to therapy. ..
  8. Fischer C, Müller C, Reber J, Müller A, Krämer S, Ametamey S, et al. [18F]fluoro-deoxy-glucose folate: a novel PET radiotracer with improved in vivo properties for folate receptor targeting. Bioconjug Chem. 2012;23:805-13 pubmed publisher
    ..i.). No radiometabolites were detected in blood, urine, and liver tissue up to 30 min after injection of [(18)F]3. [(18)F]-fluoro-deoxy-glucose-folate ([(18)F]3) is thus a promising PET radioligand for imaging FR-positive tumors. ..
  9. Vavere A, Butch E, Dearling J, Packard A, Navid F, Shulkin B, et al. 64Cu-p-NH2-Bn-DOTA-hu14.18K322A, a PET radiotracer targeting neuroblastoma and melanoma. J Nucl Med. 2012;53:1772-8 pubmed publisher
    ..64)Cu-p-NH(2)-Bn-DOTA-hu14.18K322A represents a novel PET radiotracer to facilitate clinical investigations of anti-GD2 immunotherapies and to complement other imaging modalities in the staging and treatment of neuroblastoma. ..
  10. Luurtsema G, Schuit R, Klok R, Verbeek J, Leysen J, Lammertsma A, et al. Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats. Nucl Med Biol. 2009;36:643-9 pubmed publisher
    ..Valspodar did not have any effect on cerebral uptake of [11C]laniquidar. In vivo rate of metabolism was relatively low. Further kinetic studies are needed to investigate the antagonistic behaviour of [11C]laniquidar at tracer level. ..
  11. Yoshii Y, Furukawa T, Kiyono Y, Watanabe R, Waki A, Mori T, et al. Copper-64-diacetyl-bis (N4-methylthiosemicarbazone) accumulates in rich regions of CD133+ highly tumorigenic cells in mouse colon carcinoma. Nucl Med Biol. 2010;37:395-404 pubmed publisher
    ..Therefore (64)Cu-ATSM could be a potential imaging agent for rich regions of CD133(+) cells, associated with CSCs, within tumors. ..
  12. Pan J, Pourghiasian M, Hundal N, Lau J, Benard F, Dedhar S, et al. f-[18F]fluoroethanol and 3-[18F]fluoropropanol: facile preparation, biodistribution in mice, and their application as nucleophiles in the synthesis of [18F]fluoroalkyl aryl ester and ether PET tracers. Nucl Med Biol. 2013;40:850-7 pubmed publisher
    ..This is especially important for their aryl ester derivatives which are prone to in vivo hydrolysis. ..
  13. Doyle J, Blais J, White P. Mass balance soil ingestion estimating methods and their application to inhabitants of rural and wilderness areas: a critical review. Sci Total Environ. 2010;408:2181-8 pubmed publisher
    ..Given the typically small populations in these areas, future soil ingestion studies should be focused on specific activities with a high potential for soil ingestion. ..
  14. Schmidtlein C, Beattie B, Bailey D, Akhurst T, Wang W, Gonen M, et al. Using an external gating signal to estimate noise in PET with an emphasis on tracer avid tumors. Phys Med Biol. 2010;55:6299-326 pubmed publisher
    ..Finally, a radial noise extrapolation relationship deduced in this paper was applied to patient data. ..
  15. Raffel D, Chen W, Jung Y, Jang K, Gu G, Cozzi N. Radiotracers for cardiac sympathetic innervation: transport kinetics and binding affinities for the human norepinephrine transporter. Nucl Med Biol. 2013;40:331-7 pubmed publisher
  16. Jiang Z, Liu X, Jeong E, Yu Y. Symmetry-guided design and fluorous synthesis of a stable and rapidly excreted imaging tracer for (19)F MRI. Angew Chem Int Ed Engl. 2009;48:4755-8 pubmed publisher
    ..Imaging agents such as (19)FIT can lead to (19)F magnetic resonance imaging (MRI) playing an important role in drug therapy, analogous to the role played by (1)H MRI in disease diagnosis. ..
  17. Beheshti M, Langsteger W, Fogelman I. Prostate cancer: role of SPECT and PET in imaging bone metastases. Semin Nucl Med. 2009;39:396-407 pubmed publisher
    ..However, there are presently no accurate imaging modalities to directly, reproducibly, and effectively delineate bone metastases in prostate cancer. ..
  18. Gjedsted J, Gormsen L, Buhl M, Nørrelund H, Schmitz O, Keiding S, et al. Forearm and leg amino acid metabolism in the basal state and during combined insulin and amino acid stimulation after a 3-day fast. Acta Physiol (Oxf). 2009;197:197-205 pubmed publisher
    ..Thus, as opposed to glucose and lipid metabolism, fasting does not induce insulin resistance as regards amino acid metabolism. ..
  19. Vivash L, Gregoire M, Lau E, Ware R, Binns D, Roselt P, et al. 18F-flumazenil: a ?-aminobutyric acid A-specific PET radiotracer for the localization of drug-resistant temporal lobe epilepsy. J Nucl Med. 2013;54:1270-7 pubmed publisher
  20. Xu B, Varasteh Z, Orlova A, Andersson K, Larhammar D, Björkelund H. Detecting ligand interactions with G protein-coupled receptors in real-time on living cells. Biochem Biophys Res Commun. 2013;441:820-4 pubmed publisher
    ..In conclusion, measuring binding in real-time using living cells opens up for a better understanding of ligand interactions with GPCRs. ..
  21. Pillarsetty N, Punzalan B, Larson S. 2-18F-Fluoropropionic acid as a PET imaging agent for prostate cancer. J Nucl Med. 2009;50:1709-14 pubmed publisher
    ..94 and 2.06, respectively. The data presented here indicate that (18)F-FPA accumulates in prostate cancers with high tumor-to-background ratios. (18)F-FPA has potential for use in the clinical diagnosis of prostate cancer in humans. ..
  22. Bopp C, Lundstrom C, Johnson T, Sanford R, Long P, Williams K. Uranium 238U/235U isotope ratios as indicators of reduction: results from an in situ biostimulation experiment at Rifle, Colorado, U.S.A. Environ Sci Technol. 2010;44:5927-33 pubmed publisher
    ..00046. We attribute the observed U isotope fractionation to a nuclear field shift effect during enzymatic reduction of U(VI)(aq) to U(IV)(s). ..
  23. Mattner F, Bandin D, Staykova M, Berghofer P, Gregoire M, Ballantyne P, et al. Evaluation of [¹²³I]-CLINDE as a potent SPECT radiotracer to assess the degree of astroglia activation in cuprizone-induced neuroinflammation. Eur J Nucl Med Mol Imaging. 2011;38:1516-28 pubmed publisher
    ..The highly specific TSPO radioiodinated ligand CLINDE can be used as an in vivo marker for early detection and monitoring of a variety of neuropathological conditions using noninvasive brain imaging techniques. ..
  24. Lee B, Kim D, Lee J, Sung H, Choe Y, Chi D, et al. 99mTc(CO)3-15-[N-(Acetyloxy)-2-picolylamino]pentadecanoic acid: a potential radiotracer for evaluation of fatty acid metabolism. Bioconjug Chem. 2007;18:1332-7 pubmed
    ..These results suggest that 1a is a promising radiotracer for evaluation of fatty acid metabolism in myocardium. ..
  25. Liu S, Kim Y, Zhai S, Shi J, Hou G. Evaluation of (64)Cu(DO3A-xy-TPEP) as a potential PET radiotracer for monitoring tumor multidrug resistance. Bioconjug Chem. 2009;20:790-8 pubmed publisher
    ..Thus, it is reasonable to believe that (64)Cu(DO3A-xy-TPEP), like (99m)Tc-Sestamibi, is able to localize in mitochondria due to the increased plasma and mitochondrial transmembrane potentials in tumor cells. ..
  26. Meade J, Khan S, Ataai M, DOMACH M. Use of flux pre-analysis to enable ¹³C tracer studies in pyruvate kinase-deficient Escherichia coli. Biotechnol J. 2012;7:449-60 pubmed publisher
    ..Based on the PB25 model, some suggestions are provided for how predetermining flux limits and trafficking scenarios could enable flux identification in larger network problems. ..
  27. Toyohara J, Ishiwata K. Animal tumor models for PET in drug development. Ann Nucl Med. 2011;25:717-31 pubmed publisher
    ..This review introduces sources of information and the guiding principles regarding applicability of various animal tumor models for PET in anticancer agent development especially for small animals. ..
  28. Landau S, Breault C, Joshi A, PONTECORVO M, Mathis C, Jagust W, et al. Amyloid-? imaging with Pittsburgh compound B and florbetapir: comparing radiotracers and quantification methods. J Nucl Med. 2013;54:70-7 pubmed publisher
    ..Cutoff thresholds for determining positive or negative A? status can be reliably transformed from PiB to florbetapir units or vice versa using a population scanned with both radioligands. ..
  29. Gottschaldt M, Schubert U. Prospects of metal complexes peripherally substituted with sugars in biomedicinal applications. Chemistry. 2009;15:1548-57 pubmed publisher
    ..Sugar-substitution in the periphery of metal complexes has therefore become a strongly growing field of research. Outlined herein is a selection of recent examples. ..
  30. Vandehey N, O Neil J, Slowey A, Boutchko R, Druhan J, Moses W, et al. Monitoring Tc dynamics in a bioreduced sediment: an investigation with gamma camera imaging of (99m)Tc-pertechnetate and (99m)Tc-DTPA. Environ Sci Technol. 2012;46:12583-90 pubmed publisher
    ..These experiments show the promise of [(99m)Tc]TcO(4)(-) and (99m)Tc-DTPA as noninvasive imaging probes for a redox-sensitive radiotracer and a conservative flow tracer, respectively...
  31. Fine E, Herbst L, Jelicks L, Koba W, Theele D. Small-animal research imaging devices. Semin Nucl Med. 2014;44:57-65 pubmed publisher
    ..The imaging techniques most widely used in small-animal research are CT, PET, single-photon emission CT, MRI, and optical fluorescent and luminescent imaging. ..
  32. Michelsen O, Hansen F, Albrechtsen B, Jensen P. The MG1363 and IL1403 laboratory strains of Lactococcus lactis and several dairy strains are diploid. J Bacteriol. 2010;192:1058-65 pubmed publisher
    ..The diploid and haploid strains differed in their sensitivity toward UV light, in their cell size, and in their D period, the period between termination of DNA replication and cell division. ..
  33. Debus F, Herth M, Piel M, Buchholz H, Bausbacher N, Kramer V, et al. 18F-labeling and evaluation of novel MDL 100907 derivatives as potential 5-HT2A antagonists for molecular imaging. Nucl Med Biol. 2010;37:487-95 pubmed publisher
    ..MZ hint on improved molecular imaging characteristics compared with those of [(18)F]MH.MZ. Therefore, (R)-[(18)F]MH.MZ appears to be a highly potent and selective serotonergic PET ligand in small animals. ..
  34. Ohya T, Kikuchi T, Fukumura T, Zhang M, Irie T. Non-input analysis for incomplete trapping irreversible tracer with PET. Nucl Med Biol. 2013;40:664-9 pubmed publisher
    ..The simulation results were also in reasonable agreement with the experimental ones. M-Shape can be used as the non-input analysis of incomplete trapping irreversible tracers for PET study. ..
  35. Metian M, Charbonnier L, Oberhaënsli F, Bustamante P, Jeffree R, Amiard J, et al. Assessment of metal, metalloid, and radionuclide bioaccessibility from mussels to human consumers, using centrifugation and simulated digestion methods coupled with radiotracer techniques. Ecotoxicol Environ Saf. 2009;72:1499-502 pubmed publisher
  36. Gullberg G, Reutter B, Sitek A, Maltz J, Budinger T. Dynamic single photon emission computed tomography--basic principles and cardiac applications. Phys Med Biol. 2010;55:R111-91 pubmed publisher
  37. Da Costa Branquinho E, Becker G, Bouteiller C, Jean L, Renard P, Zimmer L. Radiosynthesis and in vivo evaluation of fluorinated huprine derivates as PET radiotracers of acetylcholinesterase. Nucl Med Biol. 2013;40:554-60 pubmed publisher
    ..These results indicated that current huprine analogs are not suitable for PET mapping of brain AChE receptors, but require physicochemical modulation in order to increase brain penetration. ..
  38. Che J, Doubrovin M, Serganova I, Ageyeva L, Beresten T, Finn R, et al. HSP70-inducible hNIS-IRES-eGFP reporter imaging: response to heat shock. Mol Imaging. 2007;6:404-16 pubmed
    ..The pQHNIG70 reporter system can be used to study stress and drug responses in transduced cells and tissues. ..
  39. Man C, Toffolo G, Basu R, Rizza R, Cobelli C. Use of labeled oral minimal model to measure hepatic insulin sensitivity. Am J Physiol Endocrinol Metab. 2008;295:E1152-9 pubmed publisher
    ..Although this model requires further validation, it has the potential to improve our understanding of the role of the liver in pathophysiological states. ..
  40. Alexoff D, Dewey S, Vaska P, Krishnamoorthy S, Ferrieri R, Schueller M, et al. PET imaging of thin objects: measuring the effects of positron range and partial-volume averaging in the leaf of Nicotiana tabacum. Nucl Med Biol. 2011;38:191-200 pubmed publisher
    ..These errors can be largely corrected by integrating activity along the PET axis perpendicular to the leaf surface, including detection of escaped positrons, and calculating concentration using a measured leaf thickness. ..
  41. Frisch K, Jakobsen S, Sørensen M, Munk O, Alstrup A, Ott P, et al. [N-methyl-11C]cholylsarcosine, a novel bile acid tracer for PET/CT of hepatic excretory function: radiosynthesis and proof-of-concept studies in pigs. J Nucl Med. 2012;53:772-8 pubmed publisher
    ..This tracer may be valuable for future studies of normal and pathologic hepatic excretory functions in humans. ..
  42. Carlin S, Humm J. PET of hypoxia: current and future perspectives. J Nucl Med. 2012;53:1171-4 pubmed publisher
    ..The establishment and validation of hypoxia-directed treatment protocols are still under development, and it is envisaged that the design and use of future hypoxia PET tracers will develop as part of this process. ..
  43. Linden H, Dehdashti F. Novel methods and tracers for breast cancer imaging. Semin Nucl Med. 2013;43:324-9 pubmed publisher
  44. Vu H, O Connor P, Shoemaker R, Wan W, Fratkin M, Bear H. Intraoperative injection of radiocolloid for sentinel node biopsy in breast cancer. J Nucl Med Technol. 2013;41:263-7 pubmed publisher
    ..Intraoperative injection of radiocolloid for axillary sentinel node biopsy appears equivalent to preoperative injection and is a less painful experience for breast cancer patients. ..
  45. Pike V. PET radiotracers: crossing the blood-brain barrier and surviving metabolism. Trends Pharmacol Sci. 2009;30:431-40 pubmed publisher
  46. Wuest M, Trayner B, Grant T, Jans H, Mercer J, Murray D, et al. Radiopharmacological evaluation of 6-deoxy-6-[18F]fluoro-D-fructose as a radiotracer for PET imaging of GLUT5 in breast cancer. Nucl Med Biol. 2011;38:461-75 pubmed publisher
    ..Based on the GLUT5 specific transport and phosphorylation by ketohexokinase, 6-[(18)F]FDF may represent a novel radiotracer for PET imaging of GLUT5 and ketohexokinase-expressing tumors. ..
  47. Fiorotto M, Sosa H, Davis T. In vivo measurement of muscle protein synthesis rate using the flooding dose technique. Methods Mol Biol. 2012;798:245-64 pubmed publisher
    ..The method describes how to administer the tracer without anesthesia, the tissue collection, and the preparation of muscle and blood samples for analysis of the tracer and tracee amino acids in the precursor pool and in muscle proteins. ..
  48. Wang J, Oya S, Parhi A, Lieberman B, Ploessl K, Hou C, et al. In vivo studies of the SERT-selective [18F]FPBM and VMAT2-selective [18F]AV-133 radiotracers in a rat model of Parkinson's disease. Nucl Med Biol. 2010;37:479-86 pubmed publisher
  49. Sellers K, Fox M, Bousamra M, Slone S, Higashi R, Miller D, et al. Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation. J Clin Invest. 2015;125:687-98 pubmed publisher
    ..These findings indicate that PC-mediated anaplerosis in early-stage NSCLC is required for tumor survival and proliferation. ..
  50. Kato K, Zhang M, Suzuki K. Rapid C-carboxylation of nitro[(11)C]methane for the synthesis of ethyl nitro[2-(11)C]acetate. Mol Biosyst. 2008;4:53-5 pubmed
    ..The labelling synthesis of ethyl nitro[2-(11)C]acetate, a synthetic intermediate feasible for (11)C-labelled PET tracers, by C-carboxylation of [(11)C]MeNO(2) with 1-ethoxycarbonylbenzotriazole, and its simple application are presented...
  51. Tolmachev V, Rosik D, Wållberg H, Sjöberg A, Sandström M, Hansson M, et al. Imaging of EGFR expression in murine xenografts using site-specifically labelled anti-EGFR 111In-DOTA-Z EGFR:2377 Affibody molecule: aspect of the injected tracer amount. Eur J Nucl Med Mol Imaging. 2010;37:613-22 pubmed publisher
    ..The aim of this study was to evaluate if optimization of the injected protein dose might improve imaging of EGFR expression in tumours using a novel EGFR-targeting protein, the DOTA-Z(EGFR:2377) Affibody molecule...
  52. Skoog M, Berggren Söderlund M, Nilsson Ehle P, Xu N. Lipid synthesis and secretion in HepG2 cells is not affected by ACTH. Lipids Health Dis. 2010;9:48 pubmed publisher
    ..The present study suggests that ACTH lowers plasma lipids in humans mainly mediated by the inhibition of apoB synthesis and did not via the reduced lipid synthesis...
  53. Kong F, Ali M, Rollo A, Smith D, Zhang Y, Yu D, et al. Development of tyrosine-based radiotracer 99mTc-N4-Tyrosine for breast cancer imaging. J Biomed Biotechnol. 2012;2012:671708 pubmed publisher
    ..99m)Tc-N4-Tyrosine could thus be a useful radiotracer for use in breast tumor diagnostic imaging...
  54. Zimmermann R. Why are investors not interested in my radiotracer? The industrial and regulatory constraints in the development of radiopharmaceuticals. Nucl Med Biol. 2013;40:155-66 pubmed publisher
  55. Dickens A, Vainio S, Marjamaki P, Johansson J, Lehtiniemi P, Rokka J, et al. Detection of microglial activation in an acute model of neuroinflammation using PET and radiotracers 11C-(R)-PK11195 and 18F-GE-180. J Nucl Med. 2014;55:466-72 pubmed publisher
    ..Using immunohistochemistry, we also explore the ability of the TSPO ligands to detect activated microglial cells and astrocytes...
  56. Sivapackiam J, Harpstrite S, Prior J, MATTINGLY S, Sharma V. (67/68)Galmydar: A metalloprobe for monitoring breast cancer resistance protein (BCRP)-mediated functional transport activity. Nucl Med Biol. 2016;43:191-7 pubmed publisher
    ..Combined data indicate that Galmydar could provide a template scaffold for development of a PET tracer for imaging BCRP-mediated functional transport activity in vivo. ..
  57. Hahner S, Stuermer A, Kreissl M, Reiners C, Fassnacht M, Haenscheid H, et al. [123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes. J Clin Endocrinol Metab. 2008;93:2358-65 pubmed publisher
    ..New specific imaging methods would therefore be of great clinical value. We, therefore, studied the potential of iodometomidate (IMTO) as tracer for molecular imaging of cytochrome P450 family 11B (Cyp11B) enzymes...
  58. Weng H, Yan A, Hong C, Qin Y, Pan L, Xie L. Biogeochemical transfer and dynamics of iodine in a soil-plant system. Environ Geochem Health. 2009;31:401-11 pubmed publisher
    ..Planting vegetables such as cabbage on the 129I-contaminated soil could be a good remediation technique worthy of consideration...
  59. Nepomuceno D, Sutton S, Yu J, Zhu J, Liu C, Lovenberg T, et al. Mutagenesis studies of neuropeptide S identify a suitable peptide tracer for neuropeptide S receptor binding studies and peptides selectively activating the I(107) variant of human neuropeptide S receptor. Eur J Pharmacol. 2010;635:27-33 pubmed publisher
  60. Kealey S, Plisson C, Collier T, Long N, Husbands S, Martarello L, et al. Microfluidic reactions using [11C]carbon monoxide solutions for the synthesis of a positron emission tomography radiotracer. Org Biomol Chem. 2011;9:3313-9 pubmed publisher
    ..This corresponds to a decay corrected radiochemical yield of 7.1 ± 2.2%...
  61. Oliveira E, Faintuch B, Núñez E, Moro A, Nanda P, Smith C. Radiotracers for different angiogenesis receptors in a melanoma model. Melanoma Res. 2012;22:45-53 pubmed publisher
    ..The performance of [(99m)Tc]-MAG(3)-PEG(8)-c(RGDyk) was better than the NGR tracer with regard to human melanoma uptake. In this sense, it should be considered for future radiotracer studies of tumor diagnosis...
  62. Vodeneev V, Orlova A, Morozova E, Orlova L, Akinchits E, Orlova O, et al. The mechanism of propagation of variation potentials in wheat leaves. J Plant Physiol. 2012;169:949-54 pubmed publisher
    ..We suggest that a VP is formed by the transmission of a wound substance, the velocity of which is likely increased by hydraulic wave propagation...
  63. Warnock G, Turtoi A, Blomme A, Bretin F, Bahri M, Lemaire C, et al. In vivo PET/CT in a human glioblastoma chicken chorioallantoic membrane model: a new tool for oncology and radiotracer development. J Nucl Med. 2013;54:1782-8 pubmed publisher
    ..For the first time, to our knowledge, we demonstrate the feasibility of in vivo PET and CT imaging in a U87 glioblastoma tumor model on chicken CAM, with the aim of applying this model for screening of novel PET tracers...
  64. Kumar J, Walker M, Packiarajan M, Jubian V, Prabhakaran J, Chandrasena G, et al. Radiosynthesis and in Vivo Evaluation of Neuropeptide Y5 Receptor (NPY5R) PET Tracers. ACS Chem Neurosci. 2016;7:540-5 pubmed publisher
    ..Our studies suggest that [(18)F]LuAE00654 can be a potential PET radiotracer for the quantification and occupancy studies of NPY5R drug candidates...
  65. Vanzi E, De Cristofaro M, Ramat S, Sotgia B, Mascalchi M, Formiconi A. A direct ROI quantification method for inherent PVE correction: accuracy assessment in striatal SPECT measurements. Eur J Nucl Med Mol Imaging. 2007;34:1480-9 pubmed
    ..We evaluated the accuracy of a least squares method that allows retrieval of activity in regions of interest directly from projections (LS-ROI)...
  66. Ruzer L, Apte M. Unattached radon progeny as an experimental tool for dosimetry of nanoaerosols: proposed method and research strategy. Inhal Toxicol. 2010;22:760-6 pubmed publisher
    ..partly of 1-nm radioactive particles called unattached activity; having extremely small size and high diffusion coefficients, these particles can be potentially useful as radioactive tracers in the study of nanometer-sized aerosols.
  67. Haubner R, Beer A, Wang H, Chen X. Positron emission tomography tracers for imaging angiogenesis. Eur J Nucl Med Mol Imaging. 2010;37 Suppl 1:S86-103 pubmed publisher
  68. Cantore M, Capparelli E, Berardi F, Perrone R, Colabufo N. Clinical pharmacokinetic and metabolism of PET radiotracers for imaging P-glycoprotein in chemoresistant tumor of colorectal cancer. Curr Drug Metab. 2011;12:985-8 pubmed
  69. Aalto K, Autio A, Kiss E, Elima K, Nymalm Y, Veres T, et al. Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer. Blood. 2011;118:3725-33 pubmed publisher
    ..Thus, the peptide binding to the enzymatic groove of VAP-1 can be used for imaging conditions, such as inflammation and cancer. ..
  70. Carter S, Scholl M, Almkvist O, Wall A, Engler H, Langstrom B, et al. Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG. J Nucl Med. 2012;53:37-46 pubmed publisher
    ..Along with (11)C-DED PET, (11)C-Pittsburgh compound B ((11)C-PIB; fibrillar A? deposition), (18)F-FDG (glucose metabolism), T1 MRI, cerebrospinal fluid, and neuropsychologic data were acquired from the patients...
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    ..For this purpose, we aimed to label rhodamine-123 with carbon-11 (t(1/2)=20.4min) and to study its biodistribution in rodents...
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    ..99m)Tc-HYNIC-Aca-LSLITRL could be a promising agent for SPECT imaging of interleukin-6 receptor of ovarian cancer especially for those anti-IL-6R drugs under clinical trials, such as tocilizumab. ..
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    ..A further aim was to evaluate the concentration and time dependence in the relation between growth inhibition and PET tracer uptake as part of translational imaging activities...
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    ..We here determine the suitability of a novel carbon-11-labeled inhibitor of FAAH via ex vivo biodistribution studies in rat brain in conjunction with pharmacological challenges...
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    ..The present contribution provides a fresh perspective on an important topic in metabolic engineering, and gives practical guidelines and design principles for a priori selection of isotopic tracers for (13)C-MFA studies...
  79. Kramer Marek G, Capala J. The role of nuclear medicine in modern therapy of cancer. Tumour Biol. 2012;33:629-40 pubmed publisher
    ..For treatment, tumor-targeting agents, conjugated with therapeutic radionuclides, may be used to deposit lethal radiation at tumor sites. This review outlines the role of nuclear medicine in modern cancer therapy...
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    ..Increased adipose tissue lipolytic activity is considered an important factor in the pathogenesis of skeletal muscle insulin resistance associated with obesity...
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    ..In conclusion, during the neonatal period, the de novo pathway is the predominant source for the ornithine utilized in the synthesis of citrulline, and proline is the preferred precursor...
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    ..This influence can also affect metal potential bioavailability, considering that recently diffused metals can be more readily available to biological uptake...
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    ..In-vivo imaging of CXCR4 could provide more insight in the role of this receptor in health and disease. The aim of this study was to investigate [(99m)Tc]O?-AMD3100 as a potential SPECT tracer for imaging of CXCR4...
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    ..Overall, our results showed that transfer of Ag, Se, and Zn does actually occur from a female cuttlefish to its eggs, at least during the last two weeks before spawning...
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    ..the most commonly used PET tracer, [(18)F]Fluorodeoxyglucose ([(18)F]FDG), presents limitations in imaging prostate cancer patients, several alternative PET tracers have been proposed to evaluate by PET these patients, with promising..
  86. Hosseinimehr S, Ahmadi A, Beiki D, Mahmoudzadeh A, Babaei M, Habibi E. The radiotracer (99m)Tc-MIBI is not genotoxic for human peripheral blood lymphocytes at diagnostic radioactive dose. Genet Mol Res. 2009;8:923-8 pubmed publisher
    ..We concluded that there is no increased induction of micronuclei in lymphocytes incubated with (99m)Tc-MIBI at the radioactivity doses used for diagnostic purposes...
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    ..Thus, aim of the present study was the metabolic characterization of the two adenosine A(3) receptor PET tracers...
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    ..Routine measurement of radioactivity for all sentinel node specimens in the pathology laboratory is recommended...
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    ..This pathway may also allow access of antibodies and toxic molecules to the internodal axon in paraneoplastic syndromes and demyelinating diseases...
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    ..We have developed a bolus stable isotope-labeling kinetics (SILK) technique coupled with multiple reaction monitoring mass spectrometry to measure the clearance of proteins in the mouse brain...