gallium radioisotopes

Summary

Summary: Unstable isotopes of gallium that decay or disintegrate emitting radiation. Ga atoms with atomic weights 63-68, 70 and 72-76 are radioactive gallium isotopes.

Top Publications

  1. Gebhardt P, Opfermann T, Saluz H. Computer controlled 68Ga milking and concentration system. Appl Radiat Isot. 2010;68:1057-9 pubmed publisher
    ..It is especially suited for reproducible preparation of (68)Ga in volumes of approximately 200 microl with optimum activity for subsequent labelling of small amounts of peptides or proteins ideal for microPET applications...
  2. Hofman M, Beauregard J, Barber T, Neels O, Eu P, Hicks R. 68Ga PET/CT ventilation-perfusion imaging for pulmonary embolism: a pilot study with comparison to conventional scintigraphy. J Nucl Med. 2011;52:1513-9 pubmed publisher
    ..This pilot study assessed the feasibility of performing V/Q PET/CT and compared diagnostic utility with conventional V/Q imaging in patients with clinical suspicion of PE...
  3. Tolmachev V, Velikyan I, Sandström M, Orlova A. A HER2-binding Affibody molecule labelled with 68Ga for PET imaging: direct in vivo comparison with the 111In-labelled analogue. Eur J Nucl Med Mol Imaging. 2010;37:1356-67 pubmed publisher
    ..The goal of this study was to prepare and characterize (68)Ga-labelled ABY-002...
  4. Baum R, Prasad V, Müller D, Schuchardt C, Orlova A, Wennborg A, et al. Molecular imaging of HER2-expressing malignant tumors in breast cancer patients using synthetic 111In- or 68Ga-labeled affibody molecules. J Nucl Med. 2010;51:892-7 pubmed publisher
    ..The clinical utility of a human epidermal growth factor receptor 2 (HER2)-targeting Affibody molecule for detection and characterization of HER2-positive lesions was investigated in patients with recurrent metastatic breast cancer...
  5. Ren G, Zhang R, Liu Z, Webster J, Miao Z, Gambhir S, et al. A 2-helix small protein labeled with 68Ga for PET imaging of HER2 expression. J Nucl Med. 2009;50:1492-9 pubmed publisher
  6. Blom E, Langstrom B, Velikyan I. 68Ga-labeling of biotin analogues and their characterization. Bioconjug Chem. 2009;20:1146-51 pubmed publisher
    ..The tracers will be evaluated in in vitro experiments of avidin-coated islets of Langerhans and in transplantation models in vivo...
  7. Jindal T, Kumar A, Venkitaraman B, Dutta R, Kumar R. Role of (68)Ga-DOTATOC PET/CT in the evaluation of primary pulmonary carcinoids. Korean J Intern Med. 2010;25:386-91 pubmed publisher
    ..Thus, we investigated the value of (68)Ga-DOTATOC PET/CT for the diagnosis of primary pulmonary carcinoid tumors...
  8. Liu Z, Niu G, Shi J, Liu S, Wang F, Liu S, et al. (68)Ga-labeled cyclic RGD dimers with Gly3 and PEG4 linkers: promising agents for tumor integrin alphavbeta3 PET imaging. Eur J Nucl Med Mol Imaging. 2009;36:947-57 pubmed publisher
  9. Lang L, Li W, Guo N, Ma Y, Zhu L, Kiesewetter D, et al. Comparison study of [18F]FAl-NOTA-PRGD2, [18F]FPPRGD2, and [68Ga]Ga-NOTA-PRGD2 for PET imaging of U87MG tumors in mice. Bioconjug Chem. 2011;22:2415-22 pubmed publisher
    ..Considering their ease of preparation and good imaging qualities, [(18)F]FAl-NOTA-PRGD2 and [(68)Ga]NOTA-PRGD2 are promising alternatives to [(18)F]FPPRGD2 for PET imaging of tumor ?(v)?(3) integrin expression...

More Information

Publications62

  1. Petrik M, Haas H, Schrettl M, Helbok A, Blatzer M, Decristoforo C. In vitro and in vivo evaluation of selected 68Ga-siderophores for infection imaging. Nucl Med Biol. 2012;39:361-9 pubmed publisher
    ..We report here on the in vitro and in vivo evaluation of other siderophores radiolabelled with (68)Ga as potential radiopharmaceuticals for infection imaging...
  2. Afshar Oromieh A, Malcher A, Eder M, Eisenhut M, Linhart H, Hadaschik B, et al. PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions. Eur J Nucl Med Mol Imaging. 2013;40:486-95 pubmed publisher
    ..Within healthy organs, kidneys and salivary glands demonstrated the highest radiotracer uptake. Lesions suspicious for PC presented with excellent contrast as early as 1 h p.i. with high detection rates even at low PSA levels. ..
  3. Altai M, Strand J, Rosik D, Selvaraju R, Eriksson Karlström A, Orlova A, et al. Influence of nuclides and chelators on imaging using affibody molecules: comparative evaluation of recombinant affibody molecules site-specifically labeled with ??Ga and ¹¹¹In via maleimido derivatives of DOTA and NODAGA. Bioconjug Chem. 2013;24:1102-9 pubmed publisher
    ..In conclusion, influence of chelators on biodistribution of Affibody molecules depends on the radionuclides and reoptimization of labeling chemistry is required when a radionuclide label is changed...
  4. Al Nahhas A, Win Z, Szyszko T, Singh A, Nanni C, Fanti S, et al. Gallium-68 PET: a new frontier in receptor cancer imaging. Anticancer Res. 2007;27:4087-94 pubmed
  5. Eder M, Wängler B, Knackmuss S, LeGall F, Little M, Haberkorn U, et al. Tetrafluorophenolate of HBED-CC: a versatile conjugation agent for 68Ga-labeled small recombinant antibodies. Eur J Nucl Med Mol Imaging. 2008;35:1878-86 pubmed publisher
  6. Jeong J, Hong M, Chang Y, Lee Y, Kim Y, Cheon G, et al. Preparation of a promising angiogenesis PET imaging agent: 68Ga-labeled c(RGDyK)-isothiocyanatobenzyl-1,4,7-triazacyclononane-1,4,7-triacetic acid and feasibility studies in mice. J Nucl Med. 2008;49:830-6 pubmed publisher
    ..The labeled RGD so produced was subjected to an in vitro binding assay and in vivo biodistribution and PET studies...
  7. Fani M, André J, Maecke H. 68Ga-PET: a powerful generator-based alternative to cyclotron-based PET radiopharmaceuticals. Contrast Media Mol Imaging. 2008;3:67-77 pubmed publisher
    ..Kit-formulated precursors along with the generator may be provided, similar to the (99)Mo/(99m)Tc-based radiopharmacy, still the mainstay of nuclear medicine...
  8. Haug A, Auernhammer C, Wängler B, Tiling R, Schmidt G, Goke B, et al. Intraindividual comparison of 68Ga-DOTA-TATE and 18F-DOPA PET in patients with well-differentiated metastatic neuroendocrine tumours. Eur J Nucl Med Mol Imaging. 2009;36:765-70 pubmed publisher
    ..To compare the diagnostic impact of (68)Ga-DOTA-TATE and (18)F-DOPA PET in the diagnosis of well-differentiated metastatic neuroendocrine tumours (NET)...
  9. Putzer D, Gabriel M, Kendler D, Henninger B, Knoflach M, Kroiss A, et al. Comparison of (68)Ga-DOTA-Tyr(3)-octreotide and (18)F-fluoro-L-dihydroxyphenylalanine positron emission tomography in neuroendocrine tumor patients. Q J Nucl Med Mol Imaging. 2010;54:68-75 pubmed
    ..This study reports our initial experiences with these two PET modalities on initial diagnosis, staging and restaging in NET patients...
  10. Ambrosini V, Campana D, Bodei L, Nanni C, Castellucci P, Allegri V, et al. 68Ga-DOTANOC PET/CT clinical impact in patients with neuroendocrine tumors. J Nucl Med. 2010;51:669-73 pubmed publisher
    ..The aim of this study was to assess the impact of (68)Ga-DOTANOC PET/CT on the clinical management of NET patients...
  11. Virgolini I, Ambrosini V, Bomanji J, Baum R, Fanti S, Gabriel M, et al. Procedure guidelines for PET/CT tumour imaging with 68Ga-DOTA-conjugated peptides: 68Ga-DOTA-TOC, 68Ga-DOTA-NOC, 68Ga-DOTA-TATE. Eur J Nucl Med Mol Imaging. 2010;37:2004-10 pubmed publisher
    ..The same has been done with the relevant and recent literature in this field and the final result has been discussed by distinguished experts...
  12. Boss A, Bisdas S, Kolb A, Hofmann M, Ernemann U, Claussen C, et al. Hybrid PET/MRI of intracranial masses: initial experiences and comparison to PET/CT. J Nucl Med. 2010;51:1198-205 pubmed publisher
  13. Jindal T, Kumar A, Venkitaraman B, Meena M, Kumar R, Malhotra A, et al. Evaluation of the role of [18F]FDG-PET/CT and [68Ga]DOTATOC-PET/CT in differentiating typical and atypical pulmonary carcinoids. Cancer Imaging. 2011;11:70-5 pubmed publisher
    ..001) in typical carcinoids compared with atypical carcinoids. The different uptake patterns on [18F]FDG and [68Ga]DOTATOC-PET/CT. and the ratio of SUVmax may be helpful in differentiating between typical and atypical carcinoids...
  14. Kramer Marek G, Shenoy N, Seidel J, Griffiths G, Choyke P, Capala J. 68Ga-DOTA-affibody molecule for in vivo assessment of HER2/neu expression with PET. Eur J Nucl Med Mol Imaging. 2011;38:1967-76 pubmed publisher
    ..Therefore, there is a need for a new means to assess HER2/neu expression in vivo. In this work, we used (68)Ga-labeled DOTA-Z(HER2:2891)-Affibody to monitor HER2/neu expression in a panel of breast cancer xenografts...
  15. Treglia G, Castaldi P, Villani M, Perotti G, de Waure C, Filice A, et al. Comparison of 18F-DOPA, 18F-FDG and 68Ga-somatostatin analogue PET/CT in patients with recurrent medullary thyroid carcinoma. Eur J Nucl Med Mol Imaging. 2012;39:569-80 pubmed publisher
    ..To retrospectively evaluate and compare (18)F-FDG, (18)F-DOPA and (68)Ga-somatostatin analogues for PET/CT in patients with residual/recurrent medullary thyroid carcinoma (MTC) suspected on the basis of elevated serum calcitonin levels...
  16. Fournier P, Dumulon Perreault V, Ait Mohand S, Tremblay S, Benard F, Lecomte R, et al. Novel radiolabeled peptides for breast and prostate tumor PET imaging: (64)Cu/and (68)Ga/NOTA-PEG-[D-Tyr(6),?Ala(11),Thi(13),Nle(14)]BBN(6-14). Bioconjug Chem. 2012;23:1687-93 pubmed publisher
    ..Considering their good imaging characteristics, both (64)Cu/NOTA-PEG-BBN(6-14) and (68)Ga/NOTA-PEG-BBN(6-14) are promising candidates for GRPR-targeted PET imaging of breast and prostate cancers...
  17. Honarvar H, Jokilaakso N, Andersson K, Malmberg J, Rosik D, Orlova A, et al. Evaluation of backbone-cyclized HER2-binding 2-helix affibody molecule for in vivo molecular imaging. Nucl Med Biol. 2013;40:378-86 pubmed publisher
    ..The goal of this study was to develop a novel 2-helix Affibody molecule based on backbone cyclization by native chemical ligation (NCL)...
  18. Li Z, Chen K, Chen X. (68)Ga-labeled multimeric RGD peptides for microPET imaging of integrin alpha(v)beta (3) expression. Eur J Nucl Med Mol Imaging. 2008;35:1100-8 pubmed publisher
    ..The goal of this study was to investigate the feasibility of (68)Ga-labeled RGD peptides for tumor imaging...
  19. Kwekkeboom D, Kam B, van Essen M, Teunissen J, van Eijck C, Valkema R, et al. Somatostatin-receptor-based imaging and therapy of gastroenteropancreatic neuroendocrine tumors. Endocr Relat Cancer. 2010;17:R53-73 pubmed publisher
    ..If more widespread use of PRRT can be guaranteed, such therapy may well become the therapy of first choice in patients with metastasized or inoperable GEPNETs...
  20. Pałyga I, Kowalska A, Gąsior Perczak D, Tarnawska Pierścińska M, Słuszniak J, Sygut J, et al. The role of PET-CT scan with somatostatin analogue labelled with gallium-68 (??Ga-DOTA-TATE PET-CT) in diagnosing patients with disseminated medullary thyroid carcinoma (MTC). Endokrynol Pol. 2010;61:507-11 pubmed
    ..Two patients with positive diagnostic imaging tests were referred for surgery including resection of cervical lymph nodes with histopathological examination for assessment of metastases...
  21. Frilling A, Sotiropoulos G, Radtke A, Malago M, Bockisch A, Kuehl H, et al. The impact of 68Ga-DOTATOC positron emission tomography/computed tomography on the multimodal management of patients with neuroendocrine tumors. Ann Surg. 2010;252:850-6 pubmed publisher
    ..To evaluate the impact of 68Ga-DOTATOC positron emission tomography (PET)/computed tomography (CT) on the multimodal management of neuroendocrine tumors (NET)...
  22. Petrik M, Haas H, Dobrozemsky G, Lass Florl C, Helbok A, Blatzer M, et al. 68Ga-siderophores for PET imaging of invasive pulmonary aspergillosis: proof of principle. J Nucl Med. 2010;51:639-45 pubmed publisher
    ..fumigatus virulence. We aimed to evaluate the potential of siderophores radiolabeled with (68)Ga, a positron emitter with complexing properties comparable to those of Fe(III), as a radiopharmaceutical for imaging IPA...
  23. Eder M, Knackmuss S, Le Gall F, Reusch U, Rybin V, Little M, et al. 68Ga-labelled recombinant antibody variants for immuno-PET imaging of solid tumours. Eur J Nucl Med Mol Imaging. 2010;37:1397-407 pubmed publisher
  24. Gehler B, Paulsen F, Oksüz M, Hauser T, Eschmann S, Bares R, et al. [68Ga]-DOTATOC-PET/CT for meningioma IMRT treatment planning. Radiat Oncol. 2009;4:56 pubmed publisher
  25. Khan M, Khan S, El Refaie S, Win Z, Rubello D, Al Nahhas A. Clinical indications for Gallium-68 positron emission tomography imaging. Eur J Surg Oncol. 2009;35:561-7 pubmed publisher
    ..The advantage of in-house preparation of (68)Ga without necessity of a cyclotron, and the new generator configuration with future possibility of freeze-dried kits would make it a promising PET agent for the future...
  26. Eder M, Schafer M, Bauder Wüst U, Hull W, Wängler C, Mier W, et al. 68Ga-complex lipophilicity and the targeting property of a urea-based PSMA inhibitor for PET imaging. Bioconjug Chem. 2012;23:688-97 pubmed publisher
    ..It could be demonstrated that the PET-imaging property of a urea-based PSMA inhibitor could significantly be improved with HBED-CC. ..
  27. Riss P, Kroll C, Nagel V, Rösch F. NODAPA-OH and NODAPA-(NCS)n: synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging. Bioorg Med Chem Lett. 2008;18:5364-7 pubmed publisher
    ..Protein binding and exemplified conjugation are also reported...
  28. Davies N, Suryo Rahmanto Y, Chitambar C, Richardson D. Resistance to the antineoplastic agent gallium nitrate results in marked alterations in intracellular iron and gallium trafficking: identification of novel intermediates. J Pharmacol Exp Ther. 2006;317:153-62 pubmed
    ..In contrast to the general view that (67)Ga and (59)Fe use the same or similar uptake pathways, we show that their distribution and trafficking is markedly different in R and S cells...
  29. Skouri H, Dec G, Friedrich M, Cooper L. Noninvasive imaging in myocarditis. J Am Coll Cardiol. 2006;48:2085-93 pubmed
    ..Novel imaging modalities that are currently in preclinical development are discussed with recommendations for future clinical research...
  30. Lendvai G, Velikyan I, Bergstrom M, Estrada S, Laryea D, Välilä M, et al. Biodistribution of 68Ga-labelled phosphodiester, phosphorothioate, and 2'-O-methyl phosphodiester oligonucleotides in normal rats. Eur J Pharm Sci. 2005;26:26-38 pubmed
    ..This study supplies a base for the further development of 68Ga-labelled oligonucleotides as pharmacokinetic tools and a potential future use for in vivo imaging of gene expression...
  31. Henze M, Schuhmacher J, Hipp P, Kowalski J, Becker D, Doll J, et al. PET imaging of somatostatin receptors using [68GA]DOTA-D-Phe1-Tyr3-octreotide: first results in patients with meningiomas. J Nucl Med. 2001;42:1053-6 pubmed
    ..Because of PET's increased spatial resolution and its ability to absolutely quantify biodistribution, a PET tracer for SSTR imaging would be desirable...
  32. Meyer G, Mäcke H, Schuhmacher J, Knapp W, Hofmann M. 68Ga-labelled DOTA-derivatised peptide ligands. Eur J Nucl Med Mol Imaging. 2004;31:1097-104 pubmed
    ..The system was set up and operated in a "hot lab" by personnel with no previous experience in the preparation of PET radiopharmaceuticals...
  33. Maecke H, Hofmann M, Haberkorn U. (68)Ga-labeled peptides in tumor imaging. J Nucl Med. 2005;46 Suppl 1:172S-8S pubmed
    ..In addition, (68)Ga-DOTA-based bombesin derivatives are being investigated with some success in patients with prostate cancer...
  34. Boerman O, Dams E, Oyen W, Corstens F, Storm G. Radiopharmaceuticals for scintigraphic imaging of infection and inflammation. Inflamm Res. 2001;50:55-64 pubmed
    ..Here, the characteristics and the diagnostic potential of established and experimental radiopharmaceuticals for infection and inflammation imaging are reviewed...
  35. Gabriel M, Decristoforo C, Kendler D, Dobrozemsky G, Heute D, Uprimny C, et al. 68Ga-DOTA-Tyr3-octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT. J Nucl Med. 2007;48:508-18 pubmed
    ..PET was compared with conventional scintigraphy and dedicated CT...
  36. Mathias C, Lewis M, Reichert D, Laforest R, Sharp T, Lewis J, et al. Preparation of 66Ga- and 68Ga-labeled Ga(III)-deferoxamine-folate as potential folate-receptor-targeted PET radiopharmaceuticals. Nucl Med Biol. 2003;30:725-31 pubmed
    ..The autoradiographic images of 1 mm tumor sections demonstrate the gross heterogeneity of the KB cell tumor xenograft, as well as subtle disparity in the regional accumulation of the two radiotracers...
  37. Hoffend J, Mier W, Schuhmacher J, Schmidt K, Dimitrakopoulou Strauss A, Strauss L, et al. Gallium-68-DOTA-albumin as a PET blood-pool marker: experimental evaluation in vivo. Nucl Med Biol. 2005;32:287-92 pubmed
    ..Our findings support clinical imaging using 68Ga-DOTA-labeled human serum albumin (HSA). The generator-produced label makes 68Ga-DOTA-labeled albumin continuously available even to centers lacking an in-house cyclotron...
  38. Roivainen A, Tolvanen T, Salomäki S, Lendvai G, Velikyan I, Numminen P, et al. 68Ga-labeled oligonucleotides for in vivo imaging with PET. J Nucl Med. 2004;45:347-55 pubmed
    ..The biologic evaluation in living rats of (68)Ga-labeled oligonucleotides as imaging agents for PET is reported...
  39. Ishizaka A, Hasegawa N, Nakamura K, Takagi Y, Takano M, Yamaguchi K, et al. Usefulness of pulmonary vascular leakiness assessment in interstitial pneumonitis. Chest. 2001;119:1455-60 pubmed
  40. Velikyan I, Beyer G, Langstrom B. Microwave-supported preparation of (68)Ga bioconjugates with high specific radioactivity. Bioconjug Chem. 2004;15:554-60 pubmed
    ..The first automated prototype using this technology is being tested...
  41. Wild D, Mäcke H, Waser B, Reubi J, Ginj M, Rasch H, et al. 68Ga-DOTANOC: a first compound for PET imaging with high affinity for somatostatin receptor subtypes 2 and 5. Eur J Nucl Med Mol Imaging. 2005;32:724 pubmed
  42. Breeman W, de Jong M, De Blois E, Bernard B, Konijnenberg M, Krenning E. Radiolabelling DOTA-peptides with 68Ga. Eur J Nucl Med Mol Imaging. 2005;32:478-85 pubmed
    ..Here we present the practical aspects and the results of radiolabelling DOTA-peptides with a TiO2-based commercially available 68Ge/68Ga generator...
  43. Henze M, Dimitrakopoulou Strauss A, Milker Zabel S, Schuhmacher J, Strauss L, Doll J, et al. Characterization of 68Ga-DOTA-D-Phe1-Tyr3-octreotide kinetics in patients with meningiomas. J Nucl Med. 2005;46:763-9 pubmed
    ..In contrast to (18)F-FDG, this ligand shows high meningioma-to-background ratios. The aim was to evaluate kinetic parameters in meningiomas before radiotherapy...
  44. Govindan S, Michel R, Griffiths G, Goldenberg D, Mattes M. Deferoxamine as a chelator for 67Ga in the preparation of antibody conjugates. Nucl Med Biol. 2005;32:513-9 pubmed
    ..In conclusion, DFO does not seem to be a suitable chelator for (67)Ga conjugation for our purposes...
  45. Bar Shalom R, Yefremov N, Guralnik L, Keidar Z, Engel A, Nitecki S, et al. SPECT/CT using 67Ga and 111In-labeled leukocyte scintigraphy for diagnosis of infection. J Nucl Med. 2006;47:587-94 pubmed
    ..The present study evaluated the role of SPECT/CT as an adjunct to (67)Ga (GS) or (111)In-labeled white blood cell (WBC) scintigraphy for diagnosis or localization of infection...
  46. Sharma V, Prior J, Belinsky M, Kruh G, Piwnica Worms D. Characterization of a 67Ga/68Ga radiopharmaceutical for SPECT and PET of MDR1 P-glycoprotein transport activity in vivo: validation in multidrug-resistant tumors and at the blood-brain barrier. J Nucl Med. 2005;46:354-64 pubmed
  47. Eisenwiener K, Prata M, Buschmann I, Zhang H, Santos A, Wenger S, et al. NODAGATOC, a new chelator-coupled somatostatin analogue labeled with [67/68Ga] and [111In] for SPECT, PET, and targeted therapeutic applications of somatostatin receptor (hsst2) expressing tumors. Bioconjug Chem. 2002;13:530-41 pubmed
    ..The results indicate an improved biological behavior which is likely due to the fact that an additional spacer group separates the chelate from the pharmacophoric part of the somatostatin analogue...
  48. Hofmann M, Maecke H, Borner R, Weckesser E, Schoffski P, Oei L, et al. Biokinetics and imaging with the somatostatin receptor PET radioligand (68)Ga-DOTATOC: preliminary data. Eur J Nucl Med. 2001;28:1751-7 pubmed
    ..It is concluded that PET using (68)Ga-DOTATOC results in high tumour to non-tumour contrast and low kidney accumulation and yields higher detection rates as compared with (111)In-octreotide scintigraphy...
  49. Ando A, Nitta K, Ando I, Sanada S, Katsuda S, Tonami N, et al. Mechanism of gallium 67 accumulation in inflammatory tissue. Eur J Nucl Med. 1990;17:21-7 pubmed
  50. Antunes P, Ginj M, Zhang H, Waser B, Baum R, Reubi J, et al. Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals?. Eur J Nucl Med Mol Imaging. 2007;34:982-93 pubmed
    ..In preclinical studies it has shown a striking superiority over its 111In-labelled congener. The purpose of this study was to evaluate whether third-generation somatostatin-based, radiogallium-labelled peptides show the same superiority...
  51. Zhang H, Schuhmacher J, Waser B, Wild D, Eisenhut M, Reubi J, et al. DOTA-PESIN, a DOTA-conjugated bombesin derivative designed for the imaging and targeted radionuclide treatment of bombesin receptor-positive tumours. Eur J Nucl Med Mol Imaging. 2007;34:1198-208 pubmed
  52. Salloum E, Brandt D, Caride V, Cornelius E, Zelterman D, Schubert W, et al. Gallium scans in the management of patients with Hodgkin's disease: a study of 101 patients. J Clin Oncol. 1997;15:518-27 pubmed
    ..To evaluate the utility of periodic gallium (67Ga) scans in the management of patients with Hodgkin's disease...
  53. Hsiao Y, Mathias C, Wey S, Fanwick P, Green M. Synthesis and biodistribution of lipophilic and monocationic gallium radiopharmaceuticals derived from N,N'-bis(3-aminopropyl)-N,N'-dimethylethylenediamine: potential agents for PET myocardial imaging with 68Ga. Nucl Med Biol. 2009;36:39-45 pubmed publisher