phosphorus isotopes

Summary

Summary: Stable phosphorus atoms that have the same atomic number as the element phosphorus, but differ in atomic weight. P-31 is a stable phosphorus isotope.

Top Publications

  1. Du F, Zhu X, Qiao H, Zhang X, Chen W. Efficient in vivo 31P magnetization transfer approach for noninvasively determining multiple kinetic parameters and metabolic fluxes of ATP metabolism in the human brain. Magn Reson Med. 2007;57:103-14 pubmed
    ..The MSS MT approach should provide an important modality for noninvasively studying the essential roles of ATP metabolism in brain bioenergetics, function, and diseases...
  2. Tzika A, Mintzopoulos D, Padfield K, Wilhelmy J, Mindrinos M, Yu H, et al. Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn. Int J Mol Med. 2008;21:201-8 pubmed
    ..That PGC-1beta is a highly inducible factor in most tissues and responds to common calcium and cyclic adenosine monophosphate (cAMP) signaling pathways strongly suggests that it may be possible to develop drugs that can induce PGC-1beta...
  3. Befroy D, Falk Petersen K, Rothman D, Shulman G. Assessment of in vivo mitochondrial metabolism by magnetic resonance spectroscopy. Methods Enzymol. 2009;457:373-93 pubmed publisher
    ..We will also examine applications of the techniques to investigate how these parameters of muscle mitochondrial metabolism are modulated in insulin resistant and endurance trained individuals...
  4. Lanza I, Bhagra S, Nair K, Port J. Measurement of human skeletal muscle oxidative capacity by 31P-MR spectroscopy: a cross-validation with in vitro measurements. J Magn Reson Imaging. 2011;34:1143-50 pubmed publisher
    ..To cross-validate skeletal muscle oxidative capacity measured by (31)P-MR spectroscopy with in vitro measurements of oxidative capacity in mitochondria isolated from muscle biopsies of the same muscle group in 18 healthy adults...
  5. Prompers J, Jeneson J, Drost M, Oomens C, Strijkers G, Nicolay K. Dynamic MRS and MRI of skeletal muscle function and biomechanics. NMR Biomed. 2006;19:927-53 pubmed
  6. Wu F, Jeneson J, Beard D. Oxidative ATP synthesis in skeletal muscle is controlled by substrate feedback. Am J Physiol Cell Physiol. 2007;292:C115-24 pubmed
  7. Meex R, Schrauwen Hinderling V, Moonen Kornips E, Schaart G, Mensink M, Phielix E, et al. Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity. Diabetes. 2010;59:572-9 pubmed publisher
    ..We examined whether exercise training could restore mitochondrial function and insulin sensitivity in patients with type 2 diabetes...
  8. Kan H, Klomp D, Wong C, Boer V, Webb A, Luijten P, et al. In vivo 31P MRS detection of an alkaline inorganic phosphate pool with short T1 in human resting skeletal muscle. NMR Biomed. 2010;23:995-1000 pubmed publisher
    ..3?±?0.4 s vs 1.4?±?0.5 s for Pi(1) and Pi(2), respectively. Together, these results suggest that the intra-mitochondrial Pi pool in resting human skeletal muscle may be visible with 31P MRS at high field...
  9. Layec G, Bringard A, Le Fur Y, Vilmen C, Micallef J, Perrey S, et al. Reproducibility assessment of metabolic variables characterizing muscle energetics in vivo: A 31P-MRS study. Magn Reson Med. 2009;62:840-54 pubmed publisher
    ..In addition, the corresponding metabolic measurements can reliably be used for longitudinal studies performed even over a long period of time...

More Information

Publications62

  1. Chance B, Im J, Nioka S, Kushmerick M. Skeletal muscle energetics with PNMR: personal views and historic perspectives. NMR Biomed. 2006;19:904-26 pubmed
    ..Some of the research has been introduced in exercise physiology. Future directions of NMR on bioenergetics, as a part of system biological approaches, are indicated...
  2. Schmid A, Szendroedi J, Chmelik M, Krssak M, Moser E, Roden M. Liver ATP synthesis is lower and relates to insulin sensitivity in patients with type 2 diabetes. Diabetes Care. 2011;34:448-53 pubmed publisher
  3. van den Broek N, De Feyter H, de Graaf L, Nicolay K, Prompers J. Intersubject differences in the effect of acidosis on phosphocreatine recovery kinetics in muscle after exercise are due to differences in proton efflux rates. Am J Physiol Cell Physiol. 2007;293:C228-37 pubmed
    ..Our study implies that simply correcting tau(PCr) for end-exercise pH is not adequate, in particular when comparing patients and control subjects, because certain disorders are characterized by altered proton efflux from muscle fibers...
  4. Forbes S, Paganini A, Slade J, Towse T, Meyer R. Phosphocreatine recovery kinetics following low- and high-intensity exercise in human triceps surae and rat posterior hindlimb muscles. Am J Physiol Regul Integr Comp Physiol. 2009;296:R161-70 pubmed publisher
    ..In addition, the observation of a fast component following high-intensity exercise is consistent with the notion that glycolytic ATP production contributes to PCr resynthesis during the initial stage of recovery...
  5. Praet S, De Feyter H, Jonkers R, Nicolay K, van Pul C, Kuipers H, et al. 31P MR spectroscopy and in vitro markers of oxidative capacity in type 2 diabetes patients. MAGMA. 2006;19:321-31 pubmed
    ..However, microvascular co-morbidity in long-standing T2D can interfere with the (31)P MRS methodology...
  6. Wolf C, Boesch S, Metzler B, Weirich Schwaiger H, Trieb T, Schocke M. Phosphorus-31 two-dimensional chemical shift imaging in the myocardium of patients with late onset of Friedreich ataxia. Mol Imaging Biol. 2008;10:24-9 pubmed
    ..The purpose of this study was to investigate cardiac function and high-energy phosphate metabolism in FRDA patients with late disease onset...
  7. Du F, Zhu X, Zhang Y, Friedman M, Zhang N, Ugurbil K, et al. Tightly coupled brain activity and cerebral ATP metabolic rate. Proc Natl Acad Sci U S A. 2008;105:6409-14 pubmed publisher
  8. Jeppesen T, Quistorff B, Wibrand F, Vissing J. 31P-MRS of skeletal muscle is not a sensitive diagnostic test for mitochondrial myopathy. J Neurol. 2007;254:29-37 pubmed
    ..Thus, (31)P-MRS should not be a routine test for MM, but may be an important research tool...
  9. Bogner W, Chmelik M, Schmid A, Moser E, Trattnig S, Gruber S. Assessment of (31)P relaxation times in the human calf muscle: a comparison between 3 T and 7 T in vivo. Magn Reson Med. 2009;62:574-82 pubmed publisher
    ..2 Hz to 11.2 +/- 1.9 Hz or +72%. At 7 T (31)P-MRS in the human calf muscle offers more than twice as much SNR per unit time in reduced measurement time compared to 3 T. This will facilitate in vivo (31)P-MRS of the human muscle at 7 T...
  10. Schrauwen Hinderling V, Kooi M, Hesselink M, Jeneson J, Backes W, van Echteld C, et al. Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects. Diabetologia. 2007;50:113-20 pubmed
    ..As obesity is an independent determinant of IMCL content, we examined mitochondrial function and IMCL content in overweight type 2 diabetes patients and BMI-matched normoglycaemic controls...
  11. Nabuurs C, Huijbregts B, Wieringa B, Hilbers C, Heerschap A. 31P saturation transfer spectroscopy predicts differential intracellular macromolecular association of ATP and ADP in skeletal muscle. J Biol Chem. 2010;285:39588-96 pubmed publisher
    ..We present a model, matching the experimental result, for ADP ? ATP exchange, in which ADP is only transiently present in the cytosol...
  12. Lim E, Hollingsworth K, Thelwall P, Taylor R. Measuring the acute effect of insulin infusion on ATP turnover rate in human skeletal muscle using phosphorus-31 magnetic resonance saturation transfer spectroscopy. NMR Biomed. 2010;23:952-7 pubmed publisher
    ..03 vs baseline). The in vivo time course of insulin stimulation of skeletal muscle ATP turnover rate is not consistent with a rate limiting effect upon the initiation of insulin-stimulated glycogen synthesis...
  13. Holloway C, Ten Hove M, Clarke K, Neubauer S. MR spectroscopy in heart failure. Front Biosci (Schol Ed). 2011;3:331-40 pubmed
    ..MRS signals from 31P, 1H, 23Na and 13C, including novel hyperpolarization techniques, have provided considerable insight into the understanding of energy metabolism in the healthy and diseased heart...
  14. Schmid A, Schrauwen Hinderling V, Andreas M, Wolzt M, Moser E, Roden M. Comparison of measuring energy metabolism by different (31) P-magnetic resonance spectroscopy techniques in resting, ischemic, and exercising muscle. Magn Reson Med. 2012;67:898-905 pubmed publisher
    ..Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc...
  15. Schmid A, Chmelik M, Szendroedi J, Krssak M, Brehm A, Moser E, et al. Quantitative ATP synthesis in human liver measured by localized 31P spectroscopy using the magnetization transfer experiment. NMR Biomed. 2008;21:437-43 pubmed
    ..In conclusion, 31P MRS at 3 T provides sufficient sensitivity to detect magnetization transfer effects and can therefore be used to assess ATP synthesis in human liver...
  16. De Feyter H, van den Broek N, Praet S, Nicolay K, van Loon L, Prompers J. Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction. Eur J Endocrinol. 2008;158:643-53 pubmed publisher
  17. Chmelik M, Schmid A, Gruber S, Szendroedi J, Krssak M, Trattnig S, et al. Three-dimensional high-resolution magnetic resonance spectroscopic imaging for absolute quantification of 31P metabolites in human liver. Magn Reson Med. 2008;60:796-802 pubmed publisher
    ..This method allows for examination of regional deviations of energy metabolism in human liver diseases...
  18. Mattei J, Bendahan D, Cozzone P. P-31 magnetic resonance spectroscopy. A tool for diagnostic purposes and pathophysiological insights in muscle diseases. Reumatismo. 2004;56:9-14 pubmed
    ..Finally, the contribution of 31P MRS to our understanding of the physiopathology of several other diseases is highlighted...
  19. Cade Menun B, Liu C, Nunlist R, McColl J. Soil and litter phosphorus-31 nuclear magnetic resonance spectroscopy: extractants, metals, and phosphorus relaxation times. J Environ Qual. 2002;31:457-65 pubmed
  20. Barbiroli B, Montagna P, Cortelli P, Iotti S, Lodi R, Barboni P, et al. Defective brain and muscle energy metabolism shown by in vivo 31P magnetic resonance spectroscopy in nonaffected carriers of 11778 mtDNA mutation. Neurology. 1995;45:1364-9 pubmed
    ..All subjects without mutation had normal brain and muscle MRS. 31P-MRS disclosed defective bioenergetics in the brain or muscle or both of all asymptomatic carriers studied from our pedigree...
  21. Bhujwalla Z, Aboagye E, Gillies R, Chacko V, Mendola C, Backer J. Nm23-transfected MDA-MB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH: a 31P nuclear magnetic resonance study in vivo and in vitro. Magn Reson Med. 1999;41:897-903 pubmed
    ..These results suggest that nm23 genes may affect suppression of metastasis through phospholipid-mediated signaling and cellular pH regulation...
  22. Kemp G, Crowe A, Anijeet H, Gong Q, Bimson W, Frostick S, et al. Abnormal mitochondrial function and muscle wasting, but normal contractile efficiency, in haemodialysed patients studied non-invasively in vivo. Nephrol Dial Transplant. 2004;19:1520-7 pubmed
  23. Scheuermann Freestone M, Madsen P, Manners D, Blamire A, Buckingham R, Styles P, et al. Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes. Circulation. 2003;107:3040-6 pubmed
    ..It is well known that patients with type 2 diabetes have increased risk of cardiovascular disease, but it is not known whether they have underlying abnormalities in cardiac or skeletal muscle high-energy phosphate metabolism...
  24. Beauvieux M, Tissier P, Gin H, Canioni P, Gallis J. Butyrate impairs energy metabolism in isolated perfused liver of fed rats. J Nutr. 2001;131:1986-92 pubmed
    ..In conclusion, the difference in the hepatic oxidation pathways of two products of intestinal fermentation (acetate and butyrate) explains their different actions on energy metabolism...
  25. van Dam L, Levitt M. BII nucleotides in the B and C forms of natural-sequence polymeric DNA: A new model for the C form of DNA. J Mol Biol. 2000;304:541-61 pubmed
    ..This work shows that the B to C transition in fibers corresponds to BI to BII conformational changes of the individual nucleotides...
  26. Hesse S, Ruijter G, Dijkema C, Visser J. Measurement of intracellular (compartmental) pH by 31P NMR in Aspergillus niger. J Biotechnol. 2000;77:5-15 pubmed
    ..6 and 1.4, respectively)...
  27. Larson Meyer D, Newcomer B, Hunter G, Hetherington H, Weinsier R. 31P MRS measurement of mitochondrial function in skeletal muscle: reliability, force-level sensitivity and relation to whole body maximal oxygen uptake. NMR Biomed. 2000;13:14-27 pubmed
    ..41-0.72; p < 0.05). These results suggest that measurements of TC(PCr), TC(ADP) and OxPhos yield reproducible results that correlate with whole-body VO(2max) and that vary in force-level sensitivity...
  28. Schimmer S, Lindner D, Schmidt P, Beck Sickinger A, Huster D, Rudolph R. Functional characterization of the in vitro folded human y(1) receptor in lipid environment. Protein Pept Lett. 2010;17:605-9 pubmed
    ..coli cultures. The in vitro refolding was carried out in the presence of lipids from bovine brain extracts. Y(1) receptors in brain lipids compete for cellular receptors in competitive binding experiments...
  29. Olejniczak S, Napora P, Gajda J, Ciesielski W, Potrzebowski M. 31P double-quantum solid-state NMR study of phosphoroorganic compounds with (O)P-O-P-(O), (S)P-O-P(S) and (S)P-S-P(O) unit. Solid State Nucl Magn Reson. 2006;30:141-9 pubmed
    ..Chi(2) error analysis is used for verification of values and orientations of chemical shift tensors (CST) parameters employed for simulation of POST-C7 buildup curves...
  30. Dezortova M, Taimr P, Skoch A, Spicak J, Hajek M. Etiology and functional status of liver cirrhosis by 31P MR spectroscopy. World J Gastroenterol. 2005;11:6926-31 pubmed
    ..To assess the functional status and etiology of liver cirrhosis by quantitative (31)P magnetic resonance spectroscopy (MRS)...
  31. Hallman T, Rojas Vargas A, Jones D, Richards J. Differential recovery from exercise and hypoxia exposure measured using 31P- and 1H-NMR in white muscle of the common carp Cyprinus carpio. J Exp Biol. 2008;211:3237-48 pubmed publisher
  32. Mellier C, Fayon F, Schnitzler V, Deniard P, Allix M, Quillard S, et al. Characterization and properties of novel gallium-doped calcium phosphate ceramics. Inorg Chem. 2011;50:8252-60 pubmed publisher
    ..Indeed, the compressive strength of these new bioceramics is enhanced in direct proportion of the Ga content, up to a 2.6-fold increase as compared to pure ?-TCP...
  33. Byrdwell W, Perry R. Liquid chromatography with dual parallel mass spectrometry and 31P nuclear magnetic resonance spectroscopy for analysis of sphingomyelin and dihydrosphingomyelin. II. Bovine milk sphingolipids. J Chromatogr A. 2007;1146:164-85 pubmed
    ..31)P NMR spectroscopy was used to conclusively confirm that DSM is a dietary component in BMS...
  34. Thelwall P. Detection of 17O-tagged phosphate by (31)P MRS: a method with potential for in vivo studies of phosphorus metabolism. Magn Reson Med. 2007;57:1168-72 pubmed
    ..Thus this method may have potential for in vivo studies of bioenergetics and the metabolism of phosphate-containing compounds...
  35. Kaflak A, Kolodziejski W. Kinetics of 1H --> 31P NMR cross-polarization in bone apatite and its mineral standards. Magn Reson Chem. 2008;46:335-41 pubmed publisher
    ..The study provides information on a structured water layer, which covers crystal surface of carbonato- and bone apatite. The layer encompasses ca 40% of apatite phosphorus and its thickness is more than ca 2 nm...
  36. Gács Baitz E, Sági G, Kajtár Peredy M. 13C-31P couplings in the study of conformational properties of some diastereomeric nucleoside-3'-thiophosphate derivatives. Nucleosides Nucleotides Nucleic Acids. 2005;24:247-57 pubmed
    ..The influence of solvent and temperature on the conformational preferences is also described...
  37. Nachbauer W, Boesch S, Schneider R, Eigentler A, Wanschitz J, Poewe W, et al. Bioenergetics of the calf muscle in Friedreich ataxia patients measured by 31P-MRS before and after treatment with recombinant human erythropoietin. PLoS ONE. 2013;8:e69229 pubmed publisher
    ..MRS did not show improved mitochondrial bioenergetics after eight weeks of rhuEPO exposition in skeletal muscle tissue of FRDA patients...
  38. Linde R, Hasselbalch S, Topp S, Paulson O, Madsen P. Global cerebral blood flow and metabolism during acute hyperketonemia in the awake and anesthetized rat. J Cereb Blood Flow Metab. 2006;26:170-80 pubmed
    ..These observations indicate that the mechanism responsible for the increase in CBF is rather a direct effect on the cerebral endothelium than via some metabolic interactions...
  39. Magkos F, Sidossis L. Methodological approaches to the study of metabolism across individual tissues in man. Curr Opin Clin Nutr Metab Care. 2005;8:501-10 pubmed
    ..This article is intended to briefly overview available methodological approaches for the study of regional metabolism in man in vivo, and to summarize recent advances in this field of research...
  40. Gabr R, Ouwerkerk R, Bottomley P. Quantifying in vivo MR spectra with circles. J Magn Reson. 2006;179:152-63 pubmed
    ..We conclude that CFIT is a stable, accurate alternative to the best existing methods of fitting in vivo data...
  41. Raja M, Raymer G, Moran G, Marsh G, Thompson R. Changes in tissue water content measured with multiple-frequency bioimpedance and metabolism measured with 31P-MRS during progressive forearm exercise. J Appl Physiol (1985). 2006;101:1070-5 pubmed
  42. Dupureur C. Unique 31P spectral response to the formation of a specific restriction enzyme-DNA complex. Nucleosides Nucleotides Nucleic Acids. 2006;25:747-64 pubmed
    ..The distinct 31P spectral signature observed for cognate DNA mirrors that observed for the enzyme, underscoring the unique features of cognate complex formation...
  43. Zivić M, Zakrzewska J, Zizić M, Bacić G. 31P NMR study of polyphosphate levels during different growth phases of Phycomyces blakesleeanus. Antonie Van Leeuwenhoek. 2007;91:169-77 pubmed
    ..Analysis of core polyphosphates, intracellular inorganic phosphate and beta-ATP signal intensities suggest the role of polyphosphates as an energy and/or a phosphate reserves during Phycomyces development...
  44. Duan Y, Peterson B, Liu F, Brown T, Ibrahim T, Kangarlu A. Computational and experimental optimization of a double-tuned (1)H/(31)P four-ring birdcage head coil for MRS at 3T. J Magn Reson Imaging. 2009;29:13-22 pubmed publisher
  45. Xu X, Yu R, Liu R, Sun J, Chen Y, Chen J, et al. [Biochemical metabolic changes detected by phosphorus-31 MR spectroscopy in liver of fasting rabbits]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010;39:143-9 pubmed
    ..To investigate the biochemical metabolic changes detected by phosphorus-31 MR spectroscopy ((31)P MRS) with pathologic changes in the liver of fasting rabbits...
  46. Aisenbrey C, Harzer U, Bauer Manz G, Bär G, Chotimah I, Bertani P, et al. Proton-decoupled 15N and 31P solid-state NMR investigations of the Pf3 coat protein in oriented phospholipid bilayers. FEBS J. 2006;273:817-28 pubmed
    ..The data suggest a model in which the protein adopts a tilted helix with an angle of approximately 30 degrees and an N-terminal 'swinging arm' at the membrane surface...
  47. Scrimgeour S, Chudek J, Cowper G, Lloyd C. (31)P solid-state MAS-NMR spectroscopy of the compounds that form in phosphate-bonded dental casting investment materials during setting. Dent Mater. 2007;23:934-43 pubmed
    ..To determine whether they differ in material originating at the center of the mix from material that adheres to the mixing bowl wall...
  48. Najjar S, Bottomley P, Schulman S, Waldron M, Steffen R, Gerstenblith G, et al. Effects of a pharmacologically-induced shift of hemoglobin-oxygen dissociation on myocardial energetics during ischemia in patients with coronary artery disease. J Cardiovasc Magn Reson. 2005;7:657-66 pubmed
    ..We evaluated whether exercise-induced myocardial ischemia can be alleviated in subjects with coronary artery disease (CAD) by enhancing oxygen release with an allosteric modifier of hemoglobin's affinity for oxygen (RSR13)...
  49. Aussenac F, Lavigne B, Dufourc E. Toward bicelle stability with ether-linked phospholipids: temperature, composition, and hydration diagrams by 2H and 31P solid-state NMR. Langmuir. 2005;21:7129-35 pubmed
  50. Sánchez Bautista S, de Godos A, Rodríguez Alfaro J, Torrecillas A, Corbalan Garcia S, Gomez Fernandez J. Interaction of the C2 domain from protein kinase C(epsilon) with model membranes. Biochemistry. 2007;46:3183-92 pubmed
    ..All these results clearly illustrate the electrostatic interaction that takes place between this C2 domain and membranes which contain POPA in the absence of Ca2+...
  51. Raymer G, Forbes S, Kowalchuk J, Thompson R, Marsh G. Prior exercise delays the onset of acidosis during incremental exercise. J Appl Physiol (1985). 2007;102:1799-805 pubmed
    ..5% PPO (SD 12.0) vs. Ramp 45.1% PPO (SD 9.1)]. In conclusion, prior heavy-intensity exercise delayed the onset of intracellular acidosis and enhanced exercise performance during a subsequent incremental exercise test...
  52. Sinha A, Hollingsworth K, Ball S, Cheetham T. Improving the vitamin D status of vitamin D deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle. J Clin Endocrinol Metab. 2013;98:E509-13 pubmed publisher
    ..The aim of this study was to examine the effects of cholecalciferol therapy on skeletal mitochondrial oxidative function in symptomatic, vitamin D-deficient individuals...
  53. Gregor C, Hietschold V, Harzer W. A ³¹P-magnet resonance spectroscopy study on the metabolism of human masseter in individuals with different vertical facial pattern. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115:406-14 pubmed publisher
    ..The clinical study should be supported by functional findings at the mRNA level after orthognathic surgery...