oxygen radioisotopes

Summary

Summary: Unstable isotopes of oxygen that decay or disintegrate emitting radiation. O atoms with atomic weights 13, 14, 15, 19, and 20 are radioactive oxygen isotopes.

Top Publications

  1. Watabe H, Jino H, Kawachi N, Teramoto N, Hayashi T, Ohta Y, et al. Parametric imaging of myocardial blood flow with 15O-water and PET using the basis function method. J Nucl Med. 2005;46:1219-24 pubmed
    ..The basis function method linearizes the solution of the 1-tissue-compartment model, which results in a computationally much faster method than the conventional nonlinear least-squares fitting method in estimating the parameters...
  2. Ibaraki M, Miura S, Shimosegawa E, Sugawara S, Mizuta T, Ishikawa A, et al. Quantification of cerebral blood flow and oxygen metabolism with 3-dimensional PET and 15O: validation by comparison with 2-dimensional PET. J Nucl Med. 2008;49:50-9 pubmed
    ..We investigated whether quantitative (15)O study with 3-dimensional PET (3D PET) shows the same degree of accuracy as 2D PET...
  3. Kudomi N, Hayashi T, Teramoto N, Watabe H, Kawachi N, Ohta Y, et al. Rapid quantitative measurement of CMRO(2) and CBF by dual administration of (15)O-labeled oxygen and water during a single PET scan-a validation study and error analysis in anesthetized monkeys. J Cereb Blood Flow Metab. 2005;25:1209-24 pubmed
    ..These results show that this fast technique has an ability for accurate assessment of CBF/CMRO(2) and also allows multiple assessment at different physiologic conditions...
  4. Katoh C, Morita K, Shiga T, Kubo N, Nakada K, Tamaki N. Improvement of algorithm for quantification of regional myocardial blood flow using 15O-water with PET. J Nucl Med. 2004;45:1908-16 pubmed
    ..Subsequently, a uniform input function was calculated for each subject using a time-activity curve in the 3D whole myocardial ROI. The uniform input function allows the mathematically simple and robust algorithm to estimate rMBF...
  5. Kajander S, Ukkonen H, Sipila H, Teras M, Knuuti J. Low radiation dose imaging of myocardial perfusion and coronary angiography with a hybrid PET/CT scanner. Clin Physiol Funct Imaging. 2009;29:81-8 pubmed publisher
    ..To test the image quality and feasibility of a sequential low radiation dose protocol for hybrid cardiac PET/CT angiography (CTA)...
  6. Mankoff D, Dunnwald L, Gralow J, Ellis G, Charlop A, Lawton T, et al. Blood flow and metabolism in locally advanced breast cancer: relationship to response to therapy. J Nucl Med. 2002;43:500-9 pubmed
  7. Treyer V, Jobin M, Burger C, Teneggi V, Buck A. Quantitative cerebral H2(15)O perfusion PET without arterial blood sampling, a method based on washout rate. Eur J Nucl Med Mol Imaging. 2003;30:572-80 pubmed
    ..It does not require arterial blood sampling, yields quantitative voxel-by-voxel maps of rCBF, and is computationally efficient and easy to implement...
  8. Schafers K, Spinks T, Camici P, Bloomfield P, Rhodes C, Law M, et al. Absolute quantification of myocardial blood flow with H(2)(15)O and 3-dimensional PET: an experimental validation. J Nucl Med. 2002;43:1031-40 pubmed
    ..The purpose of this study was to assess a 3-dimensional (3D)-only PET scanner (ECAT EXACT3D) for its use in the absolute quantification of myocardial blood flow (MBF) using H(2)(15)O...
  9. Yoshinaga K, Katoh C, Noriyasu K, Iwado Y, Furuyama H, Ito Y, et al. Reduction of coronary flow reserve in areas with and without ischemia on stress perfusion imaging in patients with coronary artery disease: a study using oxygen 15-labeled water PET. J Nucl Cardiol. 2003;10:275-83 pubmed
    ..We evaluated coronary flow reserve (CFR) using oxygen 15-labeled water in areas with and without ischemia on technetium 99m tetrofosmin stress perfusion SPECT in patients with angiographically documented CAD...

More Information

Publications62

  1. Adachi I, Gaemperli O, Valenta I, Schepis T, Siegrist P, Treyer V, et al. Assessment of myocardial perfusion by dynamic O-15-labeled water PET imaging: validation of a new fast factor analysis. J Nucl Cardiol. 2007;14:698-705 pubmed
    ..Conventional FA methods generating images from sinograms (sinoFA) are time-consuming, whereas FA can be performed on the reconstructed images (reconFA) in a fraction of time. We validated the MBF values obtained by reconFA versus sinoFA...
  2. Naum A, Laaksonen M, Tuunanen H, Oikonen V, Teräs M, Kemppainen J, et al. Motion detection and correction for dynamic ( 15)O-water myocardial perfusion PET studies. Eur J Nucl Med Mol Imaging. 2005;32:1378-83 pubmed
  3. Coles J, Fryer T, Bradley P, Nortje J, Smielewski P, Rice K, et al. Intersubject variability and reproducibility of 15O PET studies. J Cereb Blood Flow Metab. 2006;26:48-57 pubmed
    ..While ideally each centre should develop its own bank of such data, the figures provided will allow initial generic approximations of sample size for such studies...
  4. Hattori N, Bergsneider M, Wu H, Glenn T, Vespa P, Hovda D, et al. Accuracy of a method using short inhalation of (15)O-O(2) for measuring cerebral oxygen extraction fraction with PET in healthy humans. J Nucl Med. 2004;45:765-70 pubmed
    ..The purpose of this study was to test the accuracy of the short-inhalation technique for estimating OEF in healthy human volunteers...
  5. Knaapen P, Boellaard R, Götte M, van der Weerdt A, Visser C, Lammertsma A, et al. The perfusable tissue index: a marker of myocardial viability. J Nucl Cardiol. 2003;10:684-91 pubmed
  6. Koshino K, Watabe H, Hasegawa S, Hayashi T, Hatazawa J, Iida H. Development of motion correction technique for cardiac (15)O-water PET study using an optical motion tracking system. Ann Nucl Med. 2010;24:1-11 pubmed publisher
    ..We developed a motion correction system using an optical motion-tracking device to detect a subject's global movement for cardiac study...
  7. Yoshinaga K, Manabe O, Katoh C, Chen L, Klein R, Naya M, et al. Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET: comparison with 15O-labelled water PET. Eur J Nucl Med Mol Imaging. 2010;37:2233-41 pubmed publisher
  8. Ahn J, Lee D, Lee J, Kim S, Cheon G, Yeo J, et al. Quantification of regional myocardial blood flow using dynamic H2(15)O PET and factor analysis. J Nucl Med. 2001;42:782-7 pubmed
    ..Therefore, we measured rMBF using time-activity curves (TACs) obtained from factor analysis of dynamic myocardial H2(15)O PET images without the aid of C15O PET...
  9. Harms H, de Haan S, Knaapen P, Allaart C, Lammertsma A, Lubberink M. Parametric images of myocardial viability using a single 15O-H2O PET/CT scan. J Nucl Med. 2011;52:745-9 pubmed publisher
    ..The aim of this study was to generate parametric PTI images from a (15)O-H(2)O PET/CT scan without an additional (15)O-CO scan...
  10. Nesterov S, Han C, Mäki M, Kajander S, Naum A, Helenius H, et al. Myocardial perfusion quantitation with 15O-labelled water PET: high reproducibility of the new cardiac analysis software (Carimas). Eur J Nucl Med Mol Imaging. 2009;36:1594-602 pubmed publisher
    ..The goal of this study was to assess the reproducibility of results the package provides for myocardial perfusion (MP) quantitation using (15)O-labelled water...
  11. Ito H, Kanno I, Fukuda H. Human cerebral circulation: positron emission tomography studies. Ann Nucl Med. 2005;19:65-74 pubmed
    ..These findings should be considered in future studies of the pathophysiology of cerebrovascular diseases...
  12. Boellaard R, Knaapen P, Rijbroek A, Luurtsema G, Lammertsma A. Evaluation of basis function and linear least squares methods for generating parametric blood flow images using 15O-water and Positron Emission Tomography. Mol Imaging Biol. 2005;7:273-85 pubmed
    ..In this paper the performance of basis function and linear least squares methods for generating parametric flow data were evaluated...
  13. Okazawa H, Yamauchi H, Sugimoto K, Takahashi M, Toyoda H, Kishibe Y, et al. Quantitative comparison of the bolus and steady-state methods for measurement of cerebral perfusion and oxygen metabolism: positron emission tomography study using 15O-gas and water. J Cereb Blood Flow Metab. 2001;21:793-803 pubmed
    ..Increase in CBV without a change in V0 suggested the increase might mainly be caused by venous dilatation in the ischemic regions...
  14. Hofman H, Knaapen P, Boellaard R, Bondarenko O, Götte M, van Dockum W, et al. Measurement of left ventricular volumes and function with O-15-labeled carbon monoxide gated positron emission tomography: comparison with magnetic resonance imaging. J Nucl Cardiol. 2005;12:639-44 pubmed
    ..The aim of this study was to compare LV volumes and function as measured by routinely acquired blood pool images by use of gated O-15-labeled CO PET with the reference technique, cardiovascular magnetic resonance imaging (MRI)...
  15. Rimoldi O, Schafers K, Boellaard R, Turkheimer F, Stegger L, Law M, et al. Quantification of subendocardial and subepicardial blood flow using 15O-labeled water and PET: experimental validation. J Nucl Med. 2006;47:163-72 pubmed
  16. Lubberink M, Harms H, Halbmeijer R, de Haan S, Knaapen P, Lammertsma A. Low-dose quantitative myocardial blood flow imaging using 15O-water and PET without attenuation correction. J Nucl Med. 2010;51:575-80 pubmed publisher
    ..The purpose of the present study was to assess the accuracy of these MBF measurements in the absence of attenuation correction...
  17. Itoh H, Namura M, Seki H, Asai T, Tsuchiya T, Uenishi H, et al. Perfusable tissue index obtained by positron emission tomography as a marker of myocardial viability in patients with ischemic ventricular dysfunction. Circ J. 2002;66:341-4 pubmed
    ..038, p<0.0001) and was similar to that of the control segments. After revascularization, the PTI correlated with the SD of wall motion (p<0.05, r=0.58). PTI may be a good predictor of contractile recovery after revascularization...
  18. Piert M, Machulla H, Jahn M, Stahlschmidt A, Becker G, Zittel T. Coupling of porcine bone blood flow and metabolism in high-turnover bone disease measured by [(15)O]H(2)O and [(18)F]fluoride ion positron emission tomography. Eur J Nucl Med Mol Imaging. 2002;29:907-14 pubmed
    ..The increased bone metabolism in high-turnover bone disease after gastrectomy is mainly related to an up-regulation of the amount of ionic exchange of [(18)F]fluoride with the bone matrix, while tracer delivery remains unchanged...
  19. van der Veldt A, Hendrikse N, Harms H, Comans E, Postmus P, Smit E, et al. Quantitative parametric perfusion images using 15O-labeled water and a clinical PET/CT scanner: test-retest variability in lung cancer. J Nucl Med. 2010;51:1684-90 pubmed publisher
    ..The purpose of the present study was to assess validity and reproducibility of dynamic H(2)(15)O PET/CT scans for measuring tumor perfusion and validate the quantitative accuracy of parametric perfusion images...
  20. Harms H, Knaapen P, de Haan S, Halbmeijer R, Lammertsma A, Lubberink M. Automatic generation of absolute myocardial blood flow images using [15O]H2O and a clinical PET/CT scanner. Eur J Nucl Med Mol Imaging. 2011;38:930-9 pubmed publisher
    ..The aim of this study was to develop a method for generating reproducible, high-quality and quantitative parametric MBF images with minimal user intervention...
  21. Bruehlmeier M, Roelcke U, Schubiger P, Ametamey S. Assessment of hypoxia and perfusion in human brain tumors using PET with 18F-fluoromisonidazole and 15O-H2O. J Nucl Med. 2004;45:1851-9 pubmed
    ..Hypoxia predicts poor treatment response of malignant tumors. We used PET with (18)F-fluoromisonidazole ((18)F-FMISO) and (15)O-H(2)O to measure in vivo hypoxia and perfusion in patients with brain tumors...
  22. Iida H, Rhodes C, De Silva R, Yamamoto Y, Araujo L, Maseri A, et al. Myocardial tissue fraction--correction for partial volume effects and measure of tissue viability. J Nucl Med. 1991;32:2169-75 pubmed
    ..The use of 15O-water, C15O and transmission data may aid in the differentiation between perfusable and nonperfusable tissue in the infarcted myocardium...
  23. Mintun M, Raichle M, Martin W, Herscovitch P. Brain oxygen utilization measured with O-15 radiotracers and positron emission tomography. J Nucl Med. 1984;25:177-87 pubmed
    ..The technique was implemented on five normal human subjects in whom the global CMRO2 was 2.93 +/- 0.37 (s.d.) ml/min X 100 g...
  24. Muzik O, Beanlands R, Hutchins G, Mangner T, Nguyen N, Schwaiger M. Validation of nitrogen-13-ammonia tracer kinetic model for quantification of myocardial blood flow using PET. J Nucl Med. 1993;34:83-91 pubmed
    ..Using this technique, uncomplicated study protocols simplify the measurement procedures while providing excellent qualitative and quantitative information...
  25. Frackowiak R, Lenzi G, Jones T, Heather J. Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure, and normal values. J Comput Assist Tomogr. 1980;4:727-36 pubmed
    ..The method appears suitable for the study of human cerebral aerobic metabolism and blood flow under differing physiological conditions and in a wide variety of neurological disorders...
  26. Martin W, Powers W, Raichle M. Cerebral blood volume measured with inhaled C15O and positron emission tomography. J Cereb Blood Flow Metab. 1987;7:421-6 pubmed
    ..Strict quality control measures must be maintained to minimize the contamination of administered C15O with 15O-labeled CO2...
  27. Monkul E, Silva L, Narayana S, Peluso M, Zamarripa F, Nery F, et al. Abnormal resting state corticolimbic blood flow in depressed unmedicated patients with major depression: a (15)O-H(2)O PET study. Hum Brain Mapp. 2012;33:272-9 pubmed publisher
    ..These findings support previous reports of abnormalities in the resting state blood flow in the limbic-frontal structures in depressed patients compared to healthy volunteers...
  28. Mullani N, Herbst R, O Neil R, Gould K, Barron B, Abbruzzese J. Tumor blood flow measured by PET dynamic imaging of first-pass 18F-FDG uptake: a comparison with 15O-labeled water-measured blood flow. J Nucl Med. 2008;49:517-23 pubmed publisher
    ..The purpose of this study was to determine if the early uptake of 18F-FDG could be used to measure regional blood flow in tumors in the absence of 15O-water...
  29. Ohara M, Yukiiri K, Masugata H, Iwado Y, Takinami H, Nishiyama Y, et al. Relationship between myocardial flow reserve by oxygen-15 water positron emission tomography in the subacute phase of myocardial infarction and left ventricular remodeling in the chronic phase. Hypertens Res. 2008;31:1307-13 pubmed publisher
    ..45, p < 0.01). The myocardial flow reserve assessed by PET in the subacute phase after AMI was found to be related to left ventricular remodeling in the chronic phase...
  30. Slimani L, Kudomi N, Oikonen V, Jarvisalo M, Kiss J, Naum A, et al. Quantification of liver perfusion with [(15)O]H(2)O-PET and its relationship with glucose metabolism and substrate levels. J Hepatol. 2008;48:974-82 pubmed publisher
  31. Walker M, Feldmann M, Matthews J, Anton Rodriguez J, Wang S, Koepp M, et al. Optimization of methods for quantification of rCBF using high-resolution [¹?O]H?O PET images. Phys Med Biol. 2012;57:2251-71 pubmed publisher
    ..For generation of parametric images using GLLS or the autoradiographic method, a filter of ? 4 mm was required in order to suppress noise in the PET images which otherwise produced large biases in the rCBF estimates...
  32. Conway C, Sheline Y, Chibnall J, Bucholz R, Price J, Gangwani S, et al. Brain blood-flow change with acute vagus nerve stimulation in treatment-refractory major depressive disorder. Brain Stimul. 2012;5:163-71 pubmed publisher
  33. Muzik O, Mangner T, Leonard W, Kumar A, Janisse J, Granneman J. 15O PET measurement of blood flow and oxygen consumption in cold-activated human brown fat. J Nucl Med. 2013;54:523-31 pubmed publisher
    ..The objective of this study was to determine to what extent BAT thermogenesis is activated in adults during cold stress and to establish the relationship between BAT oxidative metabolism and (18)F-FDG tracer uptake...
  34. Borghammer P, Vafaee M, Ostergaard K, Rodell A, Bailey C, Cumming P. Effect of memantine on CBF and CMRO2 in patients with early Parkinson's disease. Acta Neurol Scand. 2008;117:317-23 pubmed
    ..Therefore, we hypothesized that treatment with the N-methyl-d-aspartate receptor (NMDAR) antagonist memantine would decrease regional cerebral blood flow (rCBF) and oxygen metabolism in the basal ganglia of patients with early-stage PD...
  35. Nuutila P, Peltoniemi P, Oikonen V, Larmola K, Kemppainen J, Takala T, et al. Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans: studies using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission tomography. Diabetes. 2000;49:1084-91 pubmed
    ..05). We conclude that whereas acute exercise per se increases glucose uptake via increasing glucose delivery, good insulin sensitivity modulates exercise-induced increases in glucose uptake by enhancing cellular glucose extraction...
  36. Ito H, Kanno I, Iida H, Hatazawa J, Shimosegawa E, Tamura H, et al. Arterial fraction of cerebral blood volume in humans measured by positron emission tomography. Ann Nucl Med. 2001;15:111-6 pubmed
    ..The venous plus capillary fraction of CBV was 63-70% which is a important factor for the measurement of CMRO2 with MRI...
  37. Kakiuchi T, Ohba H, Nishiyama S, Sato K, Harada N, Nakanishi S, et al. Age-related changes in muscarinic cholinergic receptors in the living brain: a PET study using N-[11C]methyl-4-piperidyl benzilate combined with cerebral blood flow measurement in conscious monkeys. Brain Res. 2001;916:22-31 pubmed
  38. Lammertsma A. Myocardial perfusion in 3 dimensions. J Nucl Med. 2002;43:1041-3 pubmed
  39. Knaapen P, van Dockum W, Bondarenko O, Kok W, Götte M, Boellaard R, et al. Delayed contrast enhancement and perfusable tissue index in hypertrophic cardiomyopathy: comparison between cardiac MRI and PET. J Nucl Med. 2005;46:923-9 pubmed
    ..The present study compares the perfusable tissue index (PTI), an alternative marker of myocardial fibrosis obtained by PET, with DCE-CMR in HCM...
  40. Munk O, Bass L, Feng H, Keiding S. Determination of regional flow by use of intravascular PET tracers: microvascular theory and experimental validation for pig livers. J Nucl Med. 2003;44:1862-70 pubmed
    ..The microvascular models, which account for concentration gradients in capillaries, are validated and compared with the standard model in a pig liver study...
  41. Boddaert N, Belin P, Chabane N, Poline J, Barthelemy C, Mouren Simeoni M, et al. Perception of complex sounds: abnormal pattern of cortical activation in autism. Am J Psychiatry. 2003;160:2057-60 pubmed
    ..In normal adults, these regions are activated by listening to speech-like sounds. To investigate auditory cortical processing in autism, the authors performed a positron emission tomography activation study...
  42. Koepp M. PET tracer technology for monitoring focal epilepsies. Expert Rev Med Devices. 2007;4:191-200 pubmed
  43. Meyer P, Sturz L, Sabri O, Buell U. Preoperative brain mapping using [15O]water activation PET provides evidence on altered language networks in an adult brain tumour patient. Eur J Nucl Med Mol Imaging. 2002;29:1705 pubmed
  44. Schaefer W, Koch K, Kuhl H, Reinartz P, Kaiser H, vom Dahl J, et al. Effects of left ventricular volume and ejection on myocardial blood flow measured by oxygen-15 water positron emission tomography in coronary heart disease. Am J Cardiol. 2003;91:469-72 pubmed
  45. Schatzberg A. Brain imaging in affective disorders: more questions about causes versus effects. Am J Psychiatry. 2002;159:1807-8 pubmed
  46. Calarge C, Andreasen N, O LEARY D. Visualizing how one brain understands another: a PET study of theory of mind. Am J Psychiatry. 2003;160:1954-64 pubmed
    ..The authors conducted a positron emission tomography (PET) study to examine the neural substrates of TOM, using a task that mimics real-life social interaction...
  47. Schäfer W, Nowak B, Kaiser H, Block S, Koch K, vom Dahl J, et al. [An approach for comparative quantification of myocardial blood flow (O-15-H2O-PET), perfusion (Tc-99m-tetrofosmin-SPECT) and metabolism (F-18-FDG-PET)]. Nuklearmedizin. 2001;40:164-71 pubmed
    ..In the present study a new approach has been developed for comparative quantification of absolute myocardial blood flow (MBF), myocardial perfusion, and myocardial metabolism in short-axis slices...
  48. Logan T, Jadali F, Egorin M, Mintun M, Sashin D, Gooding W, et al. Decreased tumor blood flow as measured by positron emission tomography in cancer patients treated with interleukin-1 and carboplatin on a phase I trial. Cancer Chemother Pharmacol. 2002;50:433-44 pubmed
  49. Zongyu C, Zhenlong N, Zhaoji Z, Jixiang Q, Yunju N. Isotopes and sustainability of ground water resources, North China Plain. Ground Water. 2005;43:485-93 pubmed
    ..The isotopic data set combined indicates that ground water in the central and littoral part of the North China Plain is being mined under non-steady state conditions...
  50. Lee J, Lee D, Ahn J, Cheon G, Kim S, Yeo J, et al. Parametric image of myocardial blood flow generated from dynamic H2(15)O PET using factor analysis and cluster analysis. Med Biol Eng Comput. 2005;43:678-85 pubmed
    ..94) and by the microsphere technique (r = 0.90). A non-invasive method is presented for generating parametric images of MBF from H2(15)O PET, using factor and cluster analysis...
  51. Sarrafzadeh A, Haux D, Plotkin M, Ludemann L, Amthauer H, Unterberg A. Bedside microdialysis reflects dysfunction of cerebral energy metabolism in patients with aneurysmal subarachnoid hemorrhage as confirmed by 15 O-H2 O-PET and 18 F-FDG-PET. J Neuroradiol. 2005;32:348-51 pubmed
    ..To compare microdialysis (MD) and positron emission tomography (PET) in the detection of ischemia in aneurysmal subarachnoid hemorrhage (SAH) patients...
  52. Ito H, Inoue K, Goto R, Kinomura S, Taki Y, Okada K, et al. Database of normal human cerebral blood flow measured by SPECT: I. Comparison between I-123-IMP, Tc-99m-HMPAO, and Tc-99m-ECD as referred with O-15 labeled water PET and voxel-based morphometry. Ann Nucl Med. 2006;20:131-8 pubmed
    ..The regional distribution of tissue fractions of gray matter determined by voxel-based morphometry was also compared with SPECT and PET CBF distributions...
  53. Bailer U, Frank G, Henry S, Price J, Meltzer C, Mathis C, et al. Exaggerated 5-HT1A but normal 5-HT2A receptor activity in individuals ill with anorexia nervosa. Biol Psychiatry. 2007;61:1090-9 pubmed
    ..Because little is known about 5-HT receptor function in AN, positron emission tomography (PET) imaging with 5-HT receptor-specific radioligands was used to characterize 5-HT1A and 5-HT2A receptors...