oxygen isotopes

Summary

Summary: Stable oxygen atoms that have the same atomic number as the element oxygen, but differ in atomic weight. O-17 and 18 are stable oxygen isotopes.

Top Publications

  1. Colman A, Blake R, Karl D, Fogel M, Turekian K. Marine phosphate oxygen isotopes and organic matter remineralization in the oceans. Proc Natl Acad Sci U S A. 2005;102:13023-8 pubmed
  2. Syberg F, Suveyzdis Y, Kötting C, Gerwert K, Hofmann E. Time-resolved Fourier transform infrared spectroscopy of the nucleotide-binding domain from the ATP-binding Cassette transporter MsbA: ATP hydrolysis is the rate-limiting step in the catalytic cycle. J Biol Chem. 2012;287:23923-31 pubmed publisher
    ..Cleavage of the ?-phosphate-?-phosphate bond was found to be the rate-limiting step; no protein-bound phosphate intermediate was resolved...
  3. Reitsema L, Crews D. Brief communication: oxygen isotopes as a biomarker for sickle-cell disease? Results from transgenic mice expressing human hemoglobin S genes. Am J Phys Anthropol. 2011;145:495-8 pubmed publisher
    ..Previous research investigating oxygen isotope fractionation during respiration among anemics suggests that oxygen isotopes in bone apatite may provide a biological marker for SCD in skeletal remains...
  4. Amiot R, Wang X, Zhou Z, Wang X, Buffetaut E, Lécuyer C, et al. Oxygen isotopes of East Asian dinosaurs reveal exceptionally cold Early Cretaceous climates. Proc Natl Acad Sci U S A. 2011;108:5179-83 pubmed publisher
  5. Brienen R, Helle G, Pons T, Guyot J, Gloor M. Oxygen isotopes in tree rings are a good proxy for Amazon precipitation and El Nino-Southern Oscillation variability. Proc Natl Acad Sci U S A. 2012;109:16957-62 pubmed publisher
    ..A century-long record from northern Bolivia shows that tree rings preserve the signal of oxygen isotopes in precipitation during the wet season, with weaker influences of temperature and vapor pressure...
  6. Matson S, Rook L, Oms O, Fox D. Carbon isotopic record of terrestrial ecosystems spanning the Late Miocene extinction of Oreopithecus bambolii, Baccinello Basin (Tuscany, Italy). J Hum Evol. 2012;63:127-39 pubmed publisher
  7. Nemutlu E, Juranic N, Zhang S, Ward L, Dutta T, Nair K, et al. Electron spray ionization mass spectrometry and 2D 31P NMR for monitoring 18O/16O isotope exchange and turnover rates of metabolic oligophosphates. Anal Bioanal Chem. 2012;403:697-706 pubmed publisher
    ..Such method is advantageous for large scale dynamic phosphometabolomic profiling of metabolic networks and acquiring information on the status of probed cellular energetic system...
  8. Nemutlu E, Zhang S, Gupta A, Juranic N, Macura S, Terzic A, et al. Dynamic phosphometabolomic profiling of human tissues and transgenic models by 18O-assisted ³¹P NMR and mass spectrometry. Physiol Genomics. 2012;44:386-402 pubmed publisher
    ..Thus, (18)O-assisted gas chromatography-mass spectrometry and (31)P NMR provide a suitable platform for dynamic phosphometabolomic profiling of the cellular energetic system enabling prediction and diagnosis of metabolic diseases states...
  9. Sternberg L, Ellsworth P. Divergent biochemical fractionation, not convergent temperature, explains cellulose oxygen isotope enrichment across latitudes. PLoS ONE. 2011;6:e28040 pubmed publisher

More Information

Publications62

  1. Offermann C, Ferrio J, Holst J, Grote R, Siegwolf R, Kayler Z, et al. The long way down--are carbon and oxygen isotope signals in the tree ring uncoupled from canopy physiological processes?. Tree Physiol. 2011;31:1088-102 pubmed publisher
  2. Welp L, Keeling R, Meijer H, Bollenbacher A, Piper S, Yoshimura K, et al. Interannual variability in the oxygen isotopes of atmospheric CO2 driven by El Niño. Nature. 2011;477:579-82 pubmed publisher
    ..Interpreting the (18)O/(16)O variability has proved difficult, however, because oxygen isotopes in CO(2) are influenced by both the carbon cycle and the water cycle...
  3. Barnaby O, Cerny R, Clarke W, Hage D. Quantitative analysis of glycation patterns in human serum albumin using 16O/18O-labeling and MALDI-TOF MS. Clin Chim Acta. 2011;412:1606-15 pubmed publisher
    ..These quantitative studies build on a recent report that has identified the early and advanced glycation products that are formed on such samples of HSA...
  4. Valentin Blasini L, Mauldin J, Maple D, Blount B. Analysis of perchlorate in human urine using ion chromatography and electrospray tandem mass spectrometry. Anal Chem. 2005;77:2475-81 pubmed
    ..025 to 100 ng/mL. This selective, sensitive, and rapid method will help elucidate any potential associations between human exposure to low levels of perchlorate and adverse health effects...
  5. Hajkova D, Rao K, Miyagi M. pH dependency of the carboxyl oxygen exchange reaction catalyzed by lysyl endopeptidase and trypsin. J Proteome Res. 2006;5:1667-73 pubmed
  6. Cernusak L, Winter K, Aranda J, Turner B. Conifers, angiosperm trees, and lianas: growth, whole-plant water and nitrogen use efficiency, and stable isotope composition ({delta}13C and {delta}18O) of seedlings grown in a tropical environment. Plant Physiol. 2008;148:642-59 pubmed publisher
    ..0001, n = 94), with some residual variation explained by mean transpiration rate. Measurements of carbon and oxygen stable isotope ratios could provide a useful means of parameterizing physiological models of tropical forest trees...
  7. Meng Z, Limbach P. Quantitation of ribonucleic acids using 18O labeling and mass spectrometry. Anal Chem. 2005;77:1891-5 pubmed
    ..This method should prove useful for quantitatively characterizing variations in RNA production and variations in the amount of posttranscriptionally modified nucleosides...
  8. Chesson L, Valenzuela L, O Grady S, Cerling T, Ehleringer J. Hydrogen and oxygen stable isotope ratios of milk in the United States. J Agric Food Chem. 2010;58:2358-63 pubmed publisher
    ..As an application example, milk water delta(18)O values were used to predict possible regions of origin for restaurant samples...
  9. Castleberry C, Lilleness K, Baldauff R, Limbach P. Minimizing 18O/16O back-exchange in the relative quantification of ribonucleic acids. J Mass Spectrom. 2009;44:1195-202 pubmed publisher
  10. Ye X, Luke B, Andresson T, Blonder J. 18O stable isotope labeling in MS-based proteomics. Brief Funct Genomic Proteomic. 2009;8:136-44 pubmed publisher
    ..Also discussed are analytical issues related to this technique, including variable (18)O exchange along with advantages and disadvantages of (16)O/(18)O labeling in comparison with other isotope-coding techniques...
  11. Sakamoto N, Seto Y, Itoh S, Kuramoto K, Fujino K, Nagashima K, et al. Remnants of the early solar system water enriched in heavy oxygen isotopes. Science. 2007;317:231-3 pubmed
  12. Heller M, Mattou H, Menzel C, Yao X. Trypsin catalyzed 16O-to-18O exchange for comparative proteomics: tandem mass spectrometry comparison using MALDI-TOF, ESI-QTOF, and ESI-ion trap mass spectrometers. J Am Soc Mass Spectrom. 2003;14:704-18 pubmed
    ..Additionally the paired y-ion signals in tandem mass spectra of (16)O/(18)O-labeled peptide pairs provide a means to confirm automatic protein identification results or even to assist de novo sequencing of yet unknown proteins...
  13. Sullivan P, Welker J. Variation in leaf physiology of Salix arctica within and across ecosystems in the High Arctic: test of a dual isotope (Delta13C and Delta18O) conceptual model. Oecologia. 2007;151:372-86 pubmed
    ..In our study, bulk leaf tissue was a better medium than leaf alpha-cellulose for application of the dual isotope approach...
  14. Mason C, Therneau T, Eckel Passow J, Johnson K, Oberg A, Olson J, et al. A method for automatically interpreting mass spectra of 18O-labeled isotopic clusters. Mol Cell Proteomics. 2007;6:305-18 pubmed
    ..We describe in detail the operation of the algorithm and demonstrate its use on datasets with known and unknown ratios...
  15. Böhlke J, Mroczkowski S, Coplen T. Oxygen isotopes in nitrate: new reference materials for 18O:17O:16O measurements and observations on nitrate-water equilibration. Rapid Commun Mass Spectrom. 2003;17:1835-46 pubmed
    ..2 per thousand; USGS32 has delta(18)O = +25.7 per thousand; USGS34 has delta(18)O = -27.9 per thousand and delta(17)O = -14.8 per thousand; and USGS35 has delta(18)O = +57.5 per thousand and delta(17)O = +51.5 per thousand...
  16. Johnson K, Muddiman D. A method for calculating 16O/18O peptide ion ratios for the relative quantification of proteomes. J Am Soc Mass Spectrom. 2004;15:437-45 pubmed
  17. Gruau G, Legeas M, Riou C, Gallacier E, Martineau F, Henin O. The oxygen isotope composition of dissolved anthropogenic phosphates: a new tool for eutrophication research?. Water Res. 2005;39:232-8 pubmed
    ..5 per thousand), cast doubt about the possibility that the oxygen isotope composition could serve as a tracer for the source of anthropogenic phosphates in waters...
  18. Miyagi M, Rao K. Proteolytic 18O-labeling strategies for quantitative proteomics. Mass Spectrom Rev. 2007;26:121-36 pubmed
  19. Ogawa M, Yoshida N. Intramolecular distribution of stable nitrogen and oxygen isotopes of nitrous oxide emitted during coal combustion. Chemosphere. 2005;61:877-87 pubmed
    ..The intramolecular distribution of nitrous oxide can be a valuable parameter to estimate the extent of decomposition reaction and to understand the reaction pathway of nitrous oxide at the high temperature...
  20. Helman Y, Barkan E, Eisenstadt D, Luz B, Kaplan A. Fractionation of the three stable oxygen isotopes by oxygen-producing and oxygen-consuming reactions in photosynthetic organisms. Plant Physiol. 2005;138:2292-8 pubmed
    ..Data obtained here showed that cleavage of water in photosystem II did not fractionate oxygen isotopes; the delta18O and delta17O of the O2 evolved were essentially identical to those of the substrate water...
  21. Hartard B, Cuntz M, Máguas C, Lakatos M. Water isotopes in desiccating lichens. Planta. 2009;231:179-93 pubmed publisher
    ..Moreover, the results represent first steps towards the development of poikilohydric organisms as a recorder of ambient vapour isotopic composition...
  22. Daux V, Lécuyer C, Héran M, Amiot R, Simon L, Fourel F, et al. Oxygen isotope fractionation between human phosphate and water revisited. J Hum Evol. 2008;55:1138-47 pubmed publisher
    ..In meat-dominated and cereal-free diets, which may have been the diets of some of our early ancestors, the shift is a little higher and the application of the regression equation would slightly overestimate delta18OW in these cases...
  23. Lai C, Ometto J, Berry J, Martinelli L, Domingues T, Ehleringer J. Life form-specific variations in leaf water oxygen-18 enrichment in Amazonian vegetation. Oecologia. 2008;157:197-210 pubmed publisher
    ..The influence of life form-specific patterns of Delta(o) was incorporated through changes in the effective path length, an important but little known parameter associated with the Péclet effect...
  24. Dzeja P, Bast P, Pucar D, Wieringa B, Terzic A. Defective metabolic signaling in adenylate kinase AK1 gene knock-out hearts compromises post-ischemic coronary reflow. J Biol Chem. 2007;282:31366-72 pubmed
    ..AK1 phosphotransfer thus transduces stress signals into adequate vascular response, providing linkage between cell bioenergetics and coronary flow...
  25. Levin N, Cerling T, Passey B, Harris J, Ehleringer J. A stable isotope aridity index for terrestrial environments. Proc Natl Acad Sci U S A. 2006;103:11201-5 pubmed
    ..Recognition of the ES-EI distinction creates the opportunity to use the (18)O composition of bioapatite as an index of terrestrial aridity...
  26. Farquhar G, Cernusak L, Barnes B. Heavy water fractionation during transpiration. Plant Physiol. 2007;143:11-8 pubmed
  27. Ramos Fernandez A, Lopez Ferrer D, Vazquez J. Improved method for differential expression proteomics using trypsin-catalyzed 18O labeling with a correction for labeling efficiency. Mol Cell Proteomics. 2007;6:1274-86 pubmed
    ..By allowing a full control over potential artifacts, our method may improve automation of the procedures for relative protein quantification using this labeling strategy...
  28. Bowen G, Wassenaar L, Hobson K. Global application of stable hydrogen and oxygen isotopes to wildlife forensics. Oecologia. 2005;143:337-48 pubmed
    ..These maps are available in GIS format at http://www.waterisotopes.org...
  29. Vermilyea A, Dixon T, Voelker B. Use of H2(18)O2 to measure absolute rates of dark H2O2 production in freshwater systems. Environ Sci Technol. 2010;44:3066-72 pubmed publisher
  30. Hobson K, Bowen G, Wassenaar L, Ferrand Y, Lormée H. Using stable hydrogen and oxygen isotope measurements of feathers to infer geographical origins of migrating European birds. Oecologia. 2004;141:477-88 pubmed
    ..Our study reveals that deltaD measurements of feathers from migratory birds in Europe may be used to track their origin and movements, and so provide a powerful investigative tool for avian migration research in Europe...
  31. Elsbury K, Paytan A, Ostrom N, Kendall C, Young M, McLaughlin K, et al. Using oxygen isotopes of phosphate to trace phosphorus sources and cycling in Lake Erie. Environ Sci Technol. 2009;43:3108-14 pubmed
    ..Identifying potential phosphorus sources to the Lake is vital for designing effective management plans for reducing nutrient inputs and associated eutrophication...
  32. Bowen G, Ehleringer J, Chesson L, Thompson A, Podlesak D, Cerling T. Dietary and physiological controls on the hydrogen and oxygen isotope ratios of hair from mid-20th century indigenous populations. Am J Phys Anthropol. 2009;139:494-504 pubmed publisher
    ..These results indicate a dual role for H and O isotopic measurements of keratin, including both biological (diet, physiology) and environmental (geographic movement, paleoclimate) reconstruction...
  33. Yeakel J, Bennett N, Koch P, Dominy N. The isotopic ecology of African mole rats informs hypotheses on the evolution of human diet. Proc Biol Sci. 2007;274:1723-30 pubmed
    ..recovered from hominin-bearing deposits. These values overlap those reported for A. africanus and P. robustus and we conclude that the USO hypothesis for hominin diets retains certain plausibility...
  34. Pucar D, Dzeja P, Bast P, Gumina R, Drahl C, Lim L, et al. Mapping hypoxia-induced bioenergetic rearrangements and metabolic signaling by 18O-assisted 31P NMR and 1H NMR spectroscopy. Mol Cell Biochem. 2004;256-257:281-9 pubmed
    ..Thus, 18O-assisted 31P NMR combined with 1H NMR provide a powerful approach in capturing rearrangements in cardiac bioenergetics, and associated metabolic signaling that underlie the cardiac adaptive response to stress...
  35. O Reilly Sternberg L. Oxygen stable isotope ratios of tree-ring cellulose: the next phase of understanding. New Phytol. 2009;181:553-62 pubmed publisher
    ..Interestingly, the results of these challenges have strengthened the tree-ring model. There are several other assumptions that can be investigated which will improve the utility of the tree-ring model...
  36. Sheshshayee M, Bindumadhava H, Ramesh R, Prasad T, Lakshminarayana M, Udayakumar M. Oxygen isotope enrichment (delta18O) as a measure of time-averaged transpiration rate. J Exp Bot. 2005;56:3033-9 pubmed
    ..Therefore, it appears that the delta18O of leaf biomass can be used as an effective surrogate for mean transpiration rate. Further, at a given vapour pressure difference, delta18O can serve as a measure of stomatal conductance as well...
  37. Gessler A, Peuke A, Keitel C, Farquhar G. Oxygen isotope enrichment of organic matter in Ricinus communis during the diel course and as affected by assimilate transport. New Phytol. 2007;174:600-13 pubmed
    ..These findings will aid field studies that characterize environmental influences on plant water balance using Delta(18)O in phloem organic matter or tree rings...
  38. Cernusak L, Farquhar G, Wong S, Stuart Williams H. Measurement and interpretation of the oxygen isotope composition of carbon dioxide respired by leaves in the dark. Plant Physiol. 2004;136:3350-63 pubmed
    ..Incorporation of the delta(18)O of leaf dark respiration into ecosystem and global scale models of C(18)OO dynamics could affect model outputs and their interpretation...
  39. Smith J, Olivier M, Greene A. Relative quantification of peptide phosphorylation in a complex mixture using 18O labeling. Physiol Genomics. 2007;31:357-63 pubmed
  40. Gehre M, Geilmann H, Richter J, Werner R, Brand W. Continuous flow 2H/1H and 18O/16O analysis of water samples with dual inlet precision. Rapid Commun Mass Spectrom. 2004;18:2650-60 pubmed
    ..This limits the usable temperature to a maximum of 1450 degrees C. Relevant gas permeation through the Al2O3 walls has not been detected up to 1600 degrees C...
  41. Cernusak L, Farquhar G, Pate J. Environmental and physiological controls over oxygen and carbon isotope composition of Tasmanian blue gum, Eucalyptus globulus. Tree Physiol. 2005;25:129-46 pubmed
    ..globulus, 13C enrichment of sink tissues compared with source leaves does not result from an enriching process within the sink tissue...
  42. Dai Q, Frederiksen J, Anderson V, Harris M, Piccirilli J. Efficient synthesis of [2'-18O]uridine and its incorporation into oligonucleotides: a new tool for mechanistic study of nucleotidyl transfer reactions by isotope effect analysis. J Org Chem. 2008;73:309-11 pubmed
    ..Conversion to the corresponding phosphoramidite enables solid-phase synthesis of [2'-(18)O] RNA substrates for isotope effect studies with nucleotidyl transferases and hydrolases...
  43. Querejeta J, Estrada Medina H, Allen M, Jiménez Osornio J. Water source partitioning among trees growing on shallow karst soils in a seasonally dry tropical climate. Oecologia. 2007;152:26-36 pubmed
    ..Water storage in subsurface soil-filled cavities and in the porous limestone bedrock is apparently sufficient to sustain adult evergreen trees throughout the pronounced dry season...
  44. Eckel Passow J, Oberg A, Therneau T, Mason C, Mahoney D, Johnson K, et al. Regression analysis for comparing protein samples with 16O/18O stable-isotope labeled mass spectrometry. Bioinformatics. 2006;22:2739-45 pubmed
    ..Although discussed in the context of (16)O/(18)O stable-isotope labeled data, the multivariable regression models are generalizable to other stable-isotope labeled technologies...
  45. Miller D, Mora C, Grissino Mayer H, Mock C, Uhle M, Sharp Z. Tree-ring isotope records of tropical cyclone activity. Proc Natl Acad Sci U S A. 2006;103:14294-7 pubmed
    ..Our results suggest the potential for a tree-ring oxygen isotope proxy record of tropical cyclone occurrence extending back many centuries based on remnant pine wood from protected areas in the southeastern U.S...
  46. Körbel S, Schumann M, Bittorf T, Krause E. Relative quantification of erythropoietin receptor-dependent phosphoproteins using in-gel 18O-labeling and tandem mass spectrometry. Rapid Commun Mass Spectrom. 2005;19:2259-71 pubmed
    ..Identification and relative quantification of more than 180 EPO receptor-dependent proteins were achieved directly based on the in-gel 18O-labeling approach...
  47. O Grady S, Wende A, Remien C, Valenzuela L, Enright L, Chesson L, et al. Aberrant water homeostasis detected by stable isotope analysis. PLoS ONE. 2010;5:e11699 pubmed publisher
  48. Wang H, Hu G, Zhang Y, Yuan Z, Zhao X, Zhu Y, et al. Optimization and quality assessment of the post-digestion 18O labeling based on urea for protein denaturation by HPLC/ESI-TOF mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878:1946-52 pubmed publisher
    ..05+/-0.31, demonstrating a good quantitation quality at the optimized conditions. This work will benefit other researchers who pair urea-based protein denaturation with a post-digestion (18)O labeling method...
  49. Prideaux G, Long J, Ayliffe L, Hellstrom J, Pillans B, Boles W, et al. An arid-adapted middle Pleistocene vertebrate fauna from south-central Australia. Nature. 2007;445:422-5 pubmed
    ..Because the 21 Nullarbor species that did not survive the Pleistocene were well adapted to dry conditions, climate change (specifically, increased aridity) is unlikely to have been significant in their extinction...
  50. Young M, McLaughlin K, Kendall C, Stringfellow W, Rollog M, Elsbury K, et al. Characterizing the oxygen isotopic composition of phosphate sources to aquatic ecosystems. Environ Sci Technol. 2009;43:5190-6 pubmed
    ..Although there is overlap in delta18Op values among the groups of samples, our results indicate that some sources are isotopically distinct and delta18Op can be used for identifying phosphate sources to aquatic systems...
  51. Kreuzer Martin H, Ehleringer J, Hegg E. Oxygen isotopes indicate most intracellular water in log-phase Escherichia coli is derived from metabolism. Proc Natl Acad Sci U S A. 2005;102:17337-41 pubmed
    ..The contribution of metabolism to intracellular water was substantially less in stationary-phase or quiescent cells...
  52. Hartard B, Maguas C, Lakatos M. Delta(18)O characteristics of lichens and their effects on evaporative processes of the subjacent soil. Isotopes Environ Health Stud. 2008;44:111-28 pubmed publisher
    ..Moreover, the results indicate that lichen mats substantially reduce evaporation rates arising from subjacent soil layers, and may alter the isotopic signal of vapour diffusing away from these layers into more depleted values...
  53. Reyes García C, Mejia Chang M, Jones G, Griffiths H. Water vapour isotopic exchange by epiphytic bromeliads in tropical dry forests reflects niche differentiation and climatic signals. Plant Cell Environ. 2008;31:828-41 pubmed publisher
    ..Bulk organic matter (delta18O(org)) is used to predict the deltaO18(vap) signal at the time of leaf expansion...