nitrogen radioisotopes

Summary

Summary: Unstable isotopes of nitrogen that decay or disintegrate emitting radiation. N atoms with atomic weights 12, 13, 16, 17, and 18 are radioactive nitrogen isotopes.

Top Publications

  1. Xiangsong Z, Xingchong S, Chang Y, Xiaoyan W, Zhifeng C. 13N-NH3 versus F-18 FDG in detection of intracranial meningioma: initial report. Clin Nucl Med. 2011;36:1003-6 pubmed publisher
    ..The aim of this study was to evaluate the capacity of PET with (13)N-NH(3) to discriminate meningioma from healthy tissue, and compare with F-18 FDG...
  2. Fritz Hansen T, Hove J, Kofoed K, Kelbaek H, Larsson H. Quantification of MRI measured myocardial perfusion reserve in healthy humans: a comparison with positron emission tomography. J Magn Reson Imaging. 2008;27:818-24 pubmed publisher
    ..To validate a noninvasive quantitative MRI technique, the K(i) perfusion method, for myocardial perfusion in humans using (13)N-ammonia PET as a reference method...
  3. Xiangsong Z, Weian C. Differentiation of recurrent astrocytoma from radiation necrosis: a pilot study with 13N-NH3 PET. J Neurooncol. 2007;82:305-11 pubmed
    ..The present study assessed the role of (13)N-NH(3) PET in differentiating recurrent cerebral astrocytoma from radiation necrosis...
  4. Renaud J, DaSilva J, Beanlands R, dekemp R. Characterizing the normal range of myocardial blood flow with ?²rubidium and ¹³N-ammonia PET imaging. J Nucl Cardiol. 2013;20:578-91 pubmed publisher
    ..The goal of this study was to investigate the trade-off between noise and accuracy in both (82)Rb and (13)N-ammonia normal databases formed using a net retention model...
  5. Muzik O, Beanlands R, Hutchins G, Mangner T, Nguyen N, Schwaiger M. Validation of nitrogen-13-ammonia tracer kinetic model for quantification of myocardial blood flow using PET. J Nucl Med. 1993;34:83-91 pubmed
    ..Using this technique, uncomplicated study protocols simplify the measurement procedures while providing excellent qualitative and quantitative information...
  6. Shi X, Zhang X, Yi C, Wang X, Chen Z, Zhang B. The combination of 13N-ammonia and 18F-FDG in predicting primary central nervous system lymphomas in immunocompetent patients. Clin Nucl Med. 2013;38:98-102 pubmed publisher
    ..In this study, we investigated whether (13)N-ammonia combined with (18)F-FDG could distinguish PCNSL from solid gliomas effectively...
  7. Houser D, Moore P, Johnson S, Lutmerding B, Branstetter B, Ridgway S, et al. Relationship of blood flow and metabolism to acoustic processing centers of the dolphin brain. J Acoust Soc Am. 2010;128:1460-6 pubmed publisher
    ..Rates of blood supply and glucose uptake in the auditory cortex, inferior colliculus, and cerebellum are consistent with a high metabolic demand of tissues which are important to the integration of auditory and other sensory inputs...
  8. Lösch S, Grupe G, Peters J. Stable isotopes and dietary adaptations in humans and animals at pre-pottery Neolithic Nevalli Cori, southeast Anatolia. Am J Phys Anthropol. 2006;131:181-93 pubmed
    ..We conclude that these animals had been deliberately nourished by their owners, whereby the overall low delta(15)N-signatures in both humans and livestock might result from the consumption of protein-rich pulses...
  9. Thornton B, Macduff J. Short-term changes in xylem N compounds in Lolium perenne following defoliation. Ann Bot. 2002;89:715-22 pubmed
    ..Low concentrations of amino acids in the xylem of defoliated plants precluded accurate discrimination of their nitrogen content into pre- and post-defoliation sources...

More Information

Publications62

  1. Kettern K, Shubin Y, Steyn G, Van Der Walt T, Coenen H, Qaim S. Formation of short-lived positron emitters in reactions of protons of energies up to 200 MeV with the target elements carbon, nitrogen and oxygen. Appl Radiat Isot. 2004;60:939-45 pubmed
    ..The agreement was found to be generally satisfactory. The data are of importance in proton therapy...
  2. Neri G, Zanco P, Zanon F, Buchberger R. Effect of biventricular pacing on metabolism and perfusion in patients affected by dilated cardiomyopathy and left bundle branch block: evaluation by positron emission tomography. Europace. 2003;5:111-5 pubmed
    ..Evaluate the possible changes in myocardial metabolism and perfusion induced by biventricular pacing (BIVP) in patients affected by dilated cardiomyopathy (DC) and left bundle branch block (LBBB)...
  3. McKiddie F, Gemmell H, Davidson E, Welch A, Egred M. The suitability of gamma camera coincidence systems for nitrogen 13-labeled ammonia myocardial perfusion imaging: a quantitative comparison with full-ring PET. J Nucl Cardiol. 2003;10:633-43 pubmed
  4. Hristov A, Huhtanen P, Rode L, Acharya S, McAllister T. Comparison of the ruminal metabolism of nitrogen from 15N-labeled alfalfa preserved as hay or as silage. J Dairy Sci. 2001;84:2738-50 pubmed
    ..When the forage component of the diet was alfalfa silage, N flux through the NPAM-N pool was remarkably high, and with both methods of preserving alfalfa forage, the exchange of tracer was most intensive through this pool...
  5. Layfield D, Venegas J. Enhanced parameter estimation from noisy PET data: Part I--methodology. Acad Radiol. 2005;12:1440-7 pubmed
    ..In this report, a method is presented that provides an alternative to degrading image resolution...
  6. Rasch T, Benevenga N. Recovery of (15)n in the body, urine, and gas phase of piglets infused intravenously with (15)n L-alanine from 12-72 hours of age. J Nutr. 2004;134:847-54 pubmed
    ..7 +/- 2.8% of infused (15)N suggests that a nitrogen-containing excretory product or metabolite may be escaping detection, but the discrepancy cannot be explained by gaseous nitrogen ((28)N(2), (29)N(2), or (30)N(2)) excretion...
  7. Cooper A, Freed B. Metabolism of [13N]ammonia in rat lung. Neurochem Int. 2005;47:103-18 pubmed
  8. Murase T, Oka M, Nampei M, Miyachi A, Nakamura T. A highly sensitive assay for xanthine oxidoreductase activity using a combination of [(13) C2 ,(15) N2 ]xanthine and liquid chromatography/triple quadrupole mass spectrometry. J Labelled Comp Radiopharm. 2016;59:214-20 pubmed publisher
    ..Hence, this combination method may be used to obtain high-sensitivity measurements required for XOR activity analysis on various organs or human plasma. ..
  9. Merhige M, Garza D, Sease D, Rowe R, Tewson T, Emran A, et al. Quantitation of the critically ischemic zone at risk during acute coronary occlusion using PET. J Nucl Med. 1991;32:1581-6 pubmed
    ..0%). We conclude that the fraction of left ventricular myocardium rendered critically ischemic during acute coronary occlusion can be measured accurately and noninvasively in vivo using perfusion imaging with positron emission tomography...
  10. Stoll H, Hutchins G, Winkle W, Nguyen A, Appledorn C, Janzen I, et al. Advantages of short-lived positron-emitting radioisotopes for intracoronary radiation therapy with liquid-filled balloons to prevent restenosis. J Nucl Med. 2001;42:1375-83 pubmed
  11. Kaltoft A, Bøttcher M, Sand N, Flø C, Nielsen T, Rehling M. 99mTc-Sestamibi SPECT is a useful technique for viability detection: results of a comparison with NH3/FDG PET. Scand Cardiovasc J. 2001;35:245-51 pubmed
    ..We hypothesized that a semi-quantitative evaluation by SPECT could delineate myocardial viability with an acceptable concordance to PET...
  12. Kiyomiya S, Nakanishi H, Uchida H, Tsuji A, Nishiyama S, Futatsubashi M, et al. Real time visualization of 13N-translocation in rice under different environmental conditions using positron emitting Ttacer imaging system. Plant Physiol. 2001;125:1743-53 pubmed
    ..These results suggest that ammonium assimilation (from the roots to the discrimination center) depends passively on water flow, but actively on NH4+-transporter(s) or glutamine synthetase(s)...
  13. Musch G, Venegas J. Positron emission tomography imaging of regional pulmonary perfusion and ventilation. Proc Am Thorac Soc. 2005;2:522-7, 508-9 pubmed
    ..This article describes insights into the pathophysiology of acute lung injury, pulmonary embolism, and asthma that have been gained by PET imaging of regional gas exchange...
  14. Schwitter J, Nanz D, Kneifel S, Bertschinger K, Buchi M, Knüsel P, et al. Assessment of myocardial perfusion in coronary artery disease by magnetic resonance: a comparison with positron emission tomography and coronary angiography. Circulation. 2001;103:2230-5 pubmed
  15. García Mayoral M, Pantoja Uceda D, Santoro J, Martinez Del Pozo A, Gavilanes J, Rico M, et al. Refined NMR structure of alpha-sarcin by 15N-1H residual dipolar couplings. Eur Biophys J. 2005;34:1057-65 pubmed
  16. Mariotti F, Pueyo M, Tome D, Berot S, Benamouzig R, Mahe S. The influence of the albumin fraction on the bioavailability and postprandial utilization of pea protein given selectively to humans. J Nutr. 2001;131:1706-13 pubmed
  17. Goldsmith P, Irvine W, Hjalmarson A, Ellder J. Variations in the HCN/HNC abundance ratio in the Orion molecular cloud. Astrophys J. 1986;310:383-91 pubmed
    ..The results suggest that the warmer portions of the cloud are dominated by different chemical pathways than those in the general interstellar cloud material...
  18. Steinmetz A, Maisey M, Hardoff R. Patterns of papillary muscle ischemia in myocardial PET. Clin Nucl Med. 2004;29:1-4 pubmed
    ..Positron emission tomography (PET), however, can adequately visualize these structures using various positron emitters...
  19. Kirsch M, Korth H. Generation, basic chemistry, and detection of N-nitrosotryptophan derivatives. Org Biomol Chem. 2007;5:3889-94 pubmed
    ..This article provides a comprehensive view of the synthesis, chemical properties, and detection methods of this class of N-nitroso compounds of potential importance in biological systems...
  20. Chen G, Branch K, Alessio A, Pham P, Tabibiazar R, Kinahan P, et al. Effect of reconstruction algorithms on myocardial blood flow measurement with 13N-ammonia PET. J Nucl Med. 2007;48:1259-65 pubmed
    ..Ordered-subsets expectation maximization (OSEM) is popular for PET studies because of better noise properties. Scant data exist on the effect of reconstruction algorithms on quantitative myocardial blood flow (MBF) estimation...
  21. Alessio A, Bassingthwaighte J, Glenny R, Caldwell J. Validation of an axially distributed model for quantification of myocardial blood flow using ¹³N-ammonia PET. J Nucl Cardiol. 2013;20:64-75 pubmed publisher
    ..Unlike compartmental models, this axially distributed approach models both the temporal and the spatial gradients in uptake and retention along the capillary...
  22. Roelants V, Bol A, Bernard X, Coppens A, Melin J, Gerber B, et al. Direct comparison between 2-dimensional and 3-dimensional PET acquisition modes for myocardial blood flow absolute quantification with O-15 water and N-13 ammonia. J Nucl Cardiol. 2006;13:220-4 pubmed
    ..The study aim was to directly compare 2D and 3D acquisition modes for the evaluation of absolute myocardial blood flow (MBF) over a wide range of flow values...
  23. Slart R, Bax J, van Veldhuisen D, van der Wall E, Irwan R, Sluiter W, et al. Prediction of functional recovery after revascularization in patients with chronic ischaemic left ventricular dysfunction: head-to-head comparison between 99mTc-sestamibi/18F-FDG DISA SPECT and 13N-ammonia/ 18F-FDG PET. Eur J Nucl Med Mol Imaging. 2006;33:716-23 pubmed
    ..The aim of this study was to compare the diagnostic performance of PET and DISA SPECT for the prediction of improvement in regional and global LV function as well as LV reverse remodelling after revascularization...
  24. Gatley S, Shea C. Radiochemical and chemical quality-assurance methods for [13N]-ammonia made from a small volume H2(16)O target. Int J Rad Appl Instrum A. 1991;42:793-6 pubmed
    ..The Rf of [13N]NH3 was 0.6. HPLC was conducted with a 25 X 0.46 cm column with 2 mL/min CH3CN/10 mM aqueous sodium 1-octanesulfonate (1:2, v/v). [13N]NH3 eluted at 3.5 min...
  25. Kilpatrick E. Method for the Determination of ¹⁵N Incorporation Percentage in Labeled Peptides and Proteins. Methods Enzymol. 2016;566:273-88 pubmed publisher
    ..Additionally, methods will be described for the empirical determination of an isotopic profile using a variety of mass spectrometry techniques. ..
  26. Golish S, Hove J, Schelbert H, Gambhir S. A fast nonlinear method for parametric imaging of myocardial perfusion by dynamic (13)N-ammonia PET. J Nucl Med. 2001;42:924-31 pubmed
    ..The purpose of the study is to compare NRE with WNLR and Patlak analysis for parametric imaging of perfusion in the canine heart by (13)N-ammonia PET...
  27. Muzik O, Duvernoy C, Beanlands R, Sawada S, Dayanikli F, Wolfe E, et al. Assessment of diagnostic performance of quantitative flow measurements in normal subjects and patients with angiographically documented coronary artery disease by means of nitrogen-13 ammonia and positron emission tomography. J Am Coll Cardiol. 1998;31:534-40 pubmed
  28. Petkova A, Tycko R. Sensitivity enhancement in structural measurements by solid state NMR through pulsed spin locking. J Magn Reson. 2002;155:293-9 pubmed
    ..Further, we demonstrate that the structural information in the solid state NMR data is not distorted by pulsed spin locking in the detection period...
  29. Fiechter M, Gebhard C, Ghadri J, Fuchs T, Pazhenkottil A, Nkoulou R, et al. Myocardial perfusion imaging with 13N-ammonia PET is a strong predictor for outcome. Int J Cardiol. 2013;167:1023-6 pubmed publisher
    ..At present, outcome data on the predictive value of MPI in (13)N-ammonia PET exist only for rather small patient populations...
  30. Wellman T, Winkler T, Costa E, Musch G, Harris R, Venegas J, et al. Effect of regional lung inflation on ventilation heterogeneity at different length scales during mechanical ventilation of normal sheep lungs. J Appl Physiol (1985). 2012;113:947-57 pubmed publisher
    ..PEEP reduces sV heterogeneity by maintaining lung expansion and airway patency at those small length scales...
  31. Harris R, Winkler T, Musch G, Vidal Melo M, Schroeder T, Tgavalekos N, et al. The prone position results in smaller ventilation defects during bronchoconstriction in asthma. J Appl Physiol (1985). 2009;107:266-74 pubmed publisher
    ..In asthma, the size and location of ventilation defects is affected by body position and likely affected by small differences in lung expansion during bronchoconstriction...
  32. Sørensen M, Munk O, Keiding S. Backflux of ammonia from brain to blood in human subjects with and without hepatic encephalopathy. Metab Brain Dis. 2009;24:237-42 pubmed publisher
    ..In conclusion, backflux of ammonia from the brain to the blood does indeed occur in both healthy subjects and cirrhotic patients with and without hepatic encephalopathy...
  33. Pack N, DiBella E, Rust T, Kadrmas D, McGann C, Butterfield R, et al. Estimating myocardial perfusion from dynamic contrast-enhanced CMR with a model-independent deconvolution method. J Cardiovasc Magn Reson. 2008;10:52 pubmed publisher
    ..We investigated these questions with a model-independent analysis method that uses iterative minimization and a temporal smoothness regularizer. Perfusion estimates using this method were compared to results from dynamic 13N-ammonia PET...
  34. Xiangsong Z, Xinjian W, Yong Z, Weian C. 13N-NH3: a selective contrast-enhancing tracer for brain tumor. Nucl Med Commun. 2008;29:1052-8 pubmed publisher
  35. Kinoshita K, Jingu S, Yamaguchi J. A surrogate analyte method to determine D-serine in mouse brain using liquid chromatography-tandem mass spectrometry. Anal Biochem. 2013;432:124-30 pubmed publisher
    ..Thus, this surrogate analyte method should be applicable to the measurement of d-serine levels as a potential biomarker for monitoring certain effects of drug candidates on the central nervous system...
  36. Ohtake N, Sato T, Fujikake H, Sueyoshi K, Ohyama T, Ishioka N, et al. Rapid N transport to pods and seeds in N-deficient soybean plants. J Exp Bot. 2001;52:277-83 pubmed
  37. Mulholland G, Kilbourn M, Moskwa J. Direct simultaneous production of [15O]water and [13N]ammonia or [18F]fluoride ion by 26 MeV proton irradiation of a double chamber water target. Int J Rad Appl Instrum A. 1990;41:1193-9 pubmed
  38. Jaroniec C, Tounge B, Herzfeld J, Griffin R. Frequency selective heteronuclear dipolar recoupling in rotating solids: accurate (13)C-(15)N distance measurements in uniformly (13)C,(15)N-labeled peptides. J Am Chem Soc. 2001;123:3507-19 pubmed
    ..5-6 A range...
  39. Fiechter M, Ghadri J, Gebhard C, Fuchs T, Pazhenkottil A, Nkoulou R, et al. Diagnostic value of 13N-ammonia myocardial perfusion PET: added value of myocardial flow reserve. J Nucl Med. 2012;53:1230-4 pubmed publisher
    ..We evaluated the added diagnostic value of MFR over MPI alone as assessed with (13)N-ammonia and PET/CT to predict angiographic coronary artery disease (CAD)...
  40. Schubert M, Oschkinat H, Schmieder P. Amino acid type-selective backbone 1H-15N-correlations for Arg and Lys. J Biomol NMR. 2001;20:379-84 pubmed
    ..The new experiments are recorded as two-dimensional 1H-15N-correlations and their performance is demonstrated with the application to a protein domain of 83 amino acids...
  41. McCarthy T, Dence C, Holmberg S, Markham J, Schuster D, Welch M. Inhaled [13N]nitric oxide: a positron emission tomography (PET) study. Nucl Med Biol. 1996;23:773-7 pubmed
    ..The administered gas contained < 1 ppm of nonradioactive nitric oxide, which is believed to be below the physiologic threshold for vasorelaxation...
  42. Chen X, Calder A, Prasitkusol P, Kyle D, Jayasuriya M. Determination of 15N isotopic enrichment and concentrations of allantoin and uric acid in urine by gas chromatography/mass spectrometry. J Mass Spectrom. 1998;33:130-7 pubmed
    ..The GC/MS method for the determination of 15N enrichment and concentration of allantoin and uric acid in urine is accurate and precise and provides a useful tool for studies on uric acid and allantoin metabolism...
  43. Wells R, Ruddy T, DeKemp R, DaSilva J, Beanlands R. Single-phase CT aligned to gated PET for respiratory motion correction in cardiac PET/CT. J Nucl Med. 2010;51:1182-90 pubmed publisher
  44. Smith J, Rayner T, Rowe M, Barras J, Peirson N, Stevens A, et al. Magnetic field-cycling NMR and (14)N, (17)O quadrupole resonance in the explosive pentaerythritol tetranitrate (PETN). J Magn Reson. 2010;204:139-44 pubmed publisher
    ..At higher frequencies, the (1)H T(1) dispersion results show well-resolved dips between 200 and 904kHz assigned to level crossing with (14)N and weaker features between 3 and 5MHz tentatively assigned to level crossing with (17)O...
  45. Miller P, Long N, Vilar R, Gee A. Synthesis of 11C, 18F, 15O, and 13N radiolabels for positron emission tomography. Angew Chem Int Ed Engl. 2008;47:8998-9033 pubmed publisher
    ..This Review highlights key aspects of the synthesis of PET radiotracers with the short-lived positron-emitting radionuclides (11)C, (18)F, (15)O, and (13)N, with emphasis on the most recent strategies...
  46. Schwitter J, DeMarco T, Kneifel S, von Schulthess G, Jörg M, Arheden H, et al. Magnetic resonance-based assessment of global coronary flow and flow reserve and its relation to left ventricular functional parameters: a comparison with positron emission tomography. Circulation. 2000;101:2696-702 pubmed
    ..Measurement of coronary sinus blood flow (CSF) by phase-contrast magnetic resonance (PC-MR) imaging at rest and during hyperemia may allow noninvasive assessment of global coronary hemodynamics...
  47. Chareonthaitawee P, Christenson S, Anderson J, Kemp B, Hodge D, Ritman E, et al. Reproducibility of measurements of regional myocardial blood flow in a model of coronary artery disease: Comparison of H215O and 13NH3 PET techniques. J Nucl Med. 2006;47:1193-201 pubmed
    ..We examined the short-term reproducibility of PET H(2)15O MBF and PET 13NH3 MBF in an animal model of chronic CAD...
  48. Britto D, Kronzucker H. Constancy of nitrogen turnover kinetics in the plant cell: insights into the integration of subcellular N fluxes. Planta. 2001;213:175-81 pubmed
    ..We propose the existence of a high-fidelity mechanism governing the timing of cytosolic N turnover, and discuss its implications for attempts to improve plants biotechnologically...
  49. Contessa G, Orsale M, Melino S, Torre V, Paci M, Desideri A, et al. Structure of calmodulin complexed with an olfactory CNG channel fragment and role of the central linker: residual dipolar couplings to evaluate calmodulin binding modes outside the kinase family. J Biomol NMR. 2005;31:185-99 pubmed
    ..Excluded regions comprise calcium binding loops and loops connecting the EF-hand motifs...
  50. Wurst S, Dugassa Gobena D, Scheu S. Earthworms and litter distribution affect plant-defensive chemistry. J Chem Ecol. 2004;30:691-701 pubmed
    ..This study documents for the first time that earthworms and the spatial distribution of litter may change plant-defensive chemistry against herbivores...
  51. Valotassiou V, Leondi A, Angelidis G, Psimadas D, Georgoulias P. SPECT and PET imaging of meningiomas. ScientificWorldJournal. 2012;2012:412580 pubmed publisher
  52. Harris R, Winkler T, Tgavalekos N, Musch G, Melo M, Schroeder T, et al. Regional pulmonary perfusion, inflation, and ventilation defects in bronchoconstricted patients with asthma. Am J Respir Crit Care Med. 2006;174:245-53 pubmed
    ..However, the regional adaptations of pulmonary perfusion (Q) to such ventilation defects have not been well studied...
  53. Arbogast L, Brinson R, Marino J. Application of Natural Isotopic Abundance ¹H-¹³C- and ¹H-¹⁵N-Correlated Two-Dimensional NMR for Evaluation of the Structure of Protein Therapeutics. Methods Enzymol. 2016;566:3-34 pubmed publisher
    ..Furthermore, strategies for the statistical comparison of 2D (1)H(N)-(15)N-amide- and (1)H-(13)C-methyl-correlated spectra are detailed. ..