iron radioisotopes

Summary

Summary: Unstable isotopes of iron that decay or disintegrate emitting radiation. Fe atoms with atomic weights 52, 53, 55, and 59-61 are radioactive iron isotopes.

Top Publications

  1. Herranz M, Idoeta R, Abelairas A, Legarda F. Uncertainties in 63Ni and 55Fe determinations using liquid scintillation counting methods. Appl Radiat Isot. 2012;70:1863-6 pubmed publisher
  2. Lubberink M, Tolmachev V, Beshara S, Lundqvist H. Quantification aspects of patient studies with 52Fe in positron emission tomography. Appl Radiat Isot. 1999;51:707-15 pubmed
    ..A model for correction of 52mMn-radioactivity in organs, based on existing data on manganese kinetics, is given. The presented corrections are discussed and illustrated in a patient study...
  3. Malek A. In vitro studies of ferric carboxymaltose on placental permeability using the dual perfusion model of human placenta. Arzneimittelforschung. 2010;60:354-61 pubmed publisher
    ..It is concluded that the iron compound FCM does not cross the placenta and may increase the integrity of placental tissue (at least under in vitro conditions), but this latter observation needs further investigation...
  4. Pecaut M, Gridley D. The impact of mouse strain on iron ion radio-immune response of leukocyte populations. Int J Radiat Biol. 2010;86:409-19 pubmed publisher
    ..The major goal of this study was to compare leukocyte population responses in two strains of mice that differ in susceptibility to radiation: C57BL/6 (resistant) and CBA/Ca (susceptible)...
  5. Villasana L, Poage C, Van Meer P, Raber J. Passive avoidance learning and memory of 56Fe sham-irradiated and irradiated human apoE transgenic mice. Radiats Biol Radioecol. 2008;48:167-70 pubmed
  6. Hurrell R, Reddy M, Burri J, Cook J. An evaluation of EDTA compounds for iron fortification of cereal-based foods. Br J Nutr. 2000;84:903-10 pubmed
  7. Takahashi M, Terada Y, Nakai I, Nakanishi H, Yoshimura E, Mori S, et al. Role of nicotianamine in the intracellular delivery of metals and plant reproductive development. Plant Cell. 2003;15:1263-80 pubmed
    ..These results suggest that a shortage of NA impaired the functions of metal-requiring proteins, including transcription factors...
  8. Ohno T, Shinohara A, Kohge I, Chiba M, Hirata T. Isotopic analysis of Fe in human red blood cells by multiple collector-ICP-mass spectrometry. Anal Sci. 2004;20:617-21 pubmed
    ..The data obtained here demonstrate that the isotopic ratios of trace metals can provide new information about metabolic efficiencies of the metallic elements...
  9. Moriya M, Linder M. Vesicular transport and apotransferrin in intestinal iron absorption, as shown in the Caco-2 cell model. Am J Physiol Gastrointest Liver Physiol. 2006;290:G301-9 pubmed

More Information

Publications62

  1. Davies N, Suryo Rahmanto Y, Chitambar C, Richardson D. Resistance to the antineoplastic agent gallium nitrate results in marked alterations in intracellular iron and gallium trafficking: identification of novel intermediates. J Pharmacol Exp Ther. 2006;317:153-62 pubmed
    ..In contrast to the general view that (67)Ga and (59)Fe use the same or similar uptake pathways, we show that their distribution and trafficking is markedly different in R and S cells...
  2. Van Ammel R, Pommé S, Sibbens G. Half-life measurement of 55Fe. Appl Radiat Isot. 2006;64:1412-6 pubmed
    ..The experimental method and the corresponding uncertainty budget are presented. The result of 1005.2+/-1.4 days is slightly higher than the current recommended values...
  3. Zhang H, Onning G, Oste R, Gramatkovski E, Hulthen L. Improved iron bioavailability in an oat-based beverage: the combined effect of citric acid addition, dephytinization and iron supplementation. Eur J Nutr. 2007;46:95-102 pubmed
    ..Iron deficiency in children is a major worldwide nutritional problem. An oat beverage was developed for 1- to 3-year-old children and different treatments were used to improve the iron bioavailability...
  4. Illum L, Church A, Butterworth M, Arien A, Whetstone J, Davis S. Development of systems for targeting the regional lymph nodes for diagnostic imaging: in vivo behaviour of colloidal PEG-coated magnetite nanospheres in the rat following interstitial administration. Pharm Res. 2001;18:640-5 pubmed
    ..The surface modification of magnetite nanospheres with poly(ethylene glycol) (PEG) has been assessed by in vitro characterisation and in vivo studies following subcutaneous administration to the rat...
  5. Richardson D, Mouralian C, Ponka P, Becker E. Development of potential iron chelators for the treatment of Friedreich's ataxia: ligands that mobilize mitochondrial iron. Biochim Biophys Acta. 2001;1536:133-40 pubmed
    ..Further studies on these ligands in animals are clearly warranted considering their potential to treat FA...
  6. Hershko C, Konijn A, Nick H, Breuer W, Cabantchik Z, Link G. ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture. Blood. 2001;97:1115-22 pubmed
    ..These unique chelating properties of ICL670A may have practical implications for current efforts to design better therapeutic strategies for the management of transfusional iron overload...
  7. Kim E, Ham S, Bradke D, Ma Q, Han O. Ascorbic acid offsets the inhibitory effect of bioactive dietary polyphenolic compounds on transepithelial iron transport in Caco-2 intestinal cells. J Nutr. 2011;141:828-34 pubmed publisher
    ..The present results indicate that the inhibitory effects of dietary polyphenols on iron absorption can be offset by ascorbic acid. Further studies are needed to confirm the current findings in vivo...
  8. Lopez de Romaña D, Pizarro F, Diazgranados D, Barba A, Olivares M, Brunser O. Effect of Helicobacter pylori infection on iron absorption in asymptomatic adults consuming wheat flour fortified with iron and zinc. Biol Trace Elem Res. 2011;144:1318-26 pubmed publisher
    ..3?±?3.3% vs. 0.3?±?2.7%, p?=?0.11). H. pylori infection has a negative effect on iron absorption in asymptomatic adults consuming iron- and zinc-fortified wheat flour...
  9. Fourquez M, Obernosterer I, Blain S. A method for the use of the radiotracer 55Fe for microautoradiography and CARD-FISH of natural bacterial communities. FEMS Microbiol Lett. 2012;337:132-9 pubmed publisher
    ..Our study demonstrates the feasibility of MICRO-CARD-FISH using the radiotracer 55Fe and provides the first description of marine bacterial assemblages actively incorporating Fe...
  10. Maurer A, Knight L, Siegel J, Elfenbein I, Adler L. Paramagnetic pyrophosphate. Preliminary studies on magnetic resonance contrast enhancement of acute myocardial infarction. Invest Radiol. 1990;25:153-63 pubmed
    ..These preliminary studies suggest that Fe-PyP potentially could serve as an MR contrast agent to localize and size acute myocardial infarcts; however, its clinical use may be limited by potential toxicity and dose limitations...
  11. Willey J, Grilly L, Howard S, Pecaut M, Obenaus A, Gridley D, et al. Bone architectural and structural properties after 56Fe26+ radiation-induced changes in body mass. Radiat Res. 2008;170:201-7 pubmed publisher
    ..Exposure to (56)Fe(26+) ions can alter trabecular microarchitecture in shielded bones. Reduced body mass seems to be correlated with these deficits of trabecular and cortical bone...
  12. Miller C, Rock J, Ridley K, Williams P, Ketley J. Utilization of lactoferrin-bound and transferrin-bound iron by Campylobacter jejuni. J Bacteriol. 2008;190:1900-11 pubmed publisher
    ..This is the first demonstration that C. jejuni is capable of acquiring iron from members of the transferrin protein family, and our data indicate a role for Cj0178 in this process...
  13. Gaitán D, Olivares M, Lonnerdal B, Brito A, Pizarro F. Non-heme iron as ferrous sulfate does not interact with heme iron absorption in humans. Biol Trace Elem Res. 2012;150:68-73 pubmed publisher
    ..We reported evidence that heme and non-heme iron as ferrous sulfate does not compete for absorption. The mechanism behind the absorption of these iron sources is not clear...
  14. Werre J, Willekens F, Bosch F, de Haans L, van der Vegt S, van den Bos A, et al. The red cell revisited--matters of life and death. Cell Mol Biol (Noisy-le-grand). 2004;50:139-45 pubmed
    ..Removal of old erythrocytes from the circulation and from donor blood may open new ways into the treatment of both bilirubin and secondary iron overload...
  15. Kossert K, Gunther E. LSC measurements of the half-life of 40K. Appl Radiat Isot. 2004;60:459-64 pubmed
    ..With the specific activity the half-life is calculated to be T1/2 = 1.248(3) x 10(9) a. The result is in reasonable agreement with other measurement results provided the same isotopic concentration of 40K is used...
  16. Grahek Z, Milanović I, Nodilo M, Rozmarić M. Sequential separation of Fe and Sr from liquid samples by using Sr resin and rapid determination of ??Fe and (??,??)Sr. Appl Radiat Isot. 2013;81:42-8 pubmed publisher
    ..The method enables efficient simultaneous separation (with high recovery) of (89,90)Sr and (55)Fe and in combination with ?erenkov counting rapid determination of (89,90)Sr...
  17. Pabón M, Lonnerdal B. Effects of type of fat in the diet on iron bioavailability assessed in suckling and weanling rats. J Trace Elem Med Biol. 2001;15:18-23 pubmed
    ..Therefore, lipid composition of infant formulas should also be taken into consideration as a factor influencing iron bioavailability...
  18. Rangaraj P, Ruttimann Johnson C, Shah V, Ludden P. Accumulation of 55Fe-labeled precursors of the iron-molybdenum cofactor of nitrogenase on NifH and NifX of Azotobacter vinelandii. J Biol Chem. 2001;276:15968-74 pubmed
    ..NifX purified from an A. vinelandii nifB strain showed a different electrophoretic mobility on anoxic native gels than did NifX with the FeMo-co precursor bound...
  19. Zweit J, Downey S, Sharma H. A method for the production of iron-52 with a very low iron-55 contamination. Int J Rad Appl Instrum A. 1988;39:1197-201 pubmed
    ..The yield of 52Fe at 38 MeV incident 4He energy is 1667 +/- 133 MBq/C (163 +/- 13 microCi/microAh) at end of bombardment and the contamination of 55Fe is only 0.008%...
  20. Natarajan M, Aravindan N, Meltz M, Herman T. Post-translational modification of I-kappa B alpha activates NF-kappa B in human monocytes exposed to 56Fe ions. Radiat Environ Biophys. 2002;41:139-44 pubmed
  21. Kicic A, Chua A, Baker E. The desferrithiocin (DFT) class of iron chelators: potential as antineoplastic agents. Anticancer Drug Des. 2001;16:195-207 pubmed
    ..This apparent selectivity of these chelators for cancer cells, coupled with their high activity, suggests that further investigation is warranted...
  22. Reddy M, Hurrell R, Cook J. Estimation of nonheme-iron bioavailability from meal composition. Am J Clin Nutr. 2000;71:937-43 pubmed
    ..Considerable data are available on the individual effects of dietary factors on nonheme-iron absorption, but their combined effect when they are present in the same meal is not known...
  23. Takeda A, Takatsuka K, Connor J, Oku N. Abnormal iron delivery to the bone marrow in neonatal hypotransferrinemic mice. Biometals. 2002;15:33-6 pubmed
    ..However, the iron seems to be unavailable for the production of hemoglobin. These results suggest that transferrin-dependent iron uptake by erythroid cells in the bone marrow is essential for the development of erythrocytes...
  24. Beard J, Wiesinger J, Li N, Connor J. Brain iron uptake in hypotransferrinemic mice: influence of systemic iron status. J Neurosci Res. 2005;79:254-61 pubmed
    ..The proteins and mechanisms responsible for additional iron uptake into specific regions, or perhaps the redistribution are unclear though the data are supportive of a non-transferrin-bound iron uptake pathway...
  25. Brooks A, Bao S, Rithidech K, Couch L, Braby L. Relative effectiveness of HZE iron-56 particles for the induction of cytogenetic damage in vivo. Radiat Res. 2001;155:353-9 pubmed
    ..The role of wasted energy in studies of cancer induction may be important in risk estimates for exposure to HZE particles...
  26. Simpson B, Van Wyngaardt W, Lubbe J. Fe-55 activity measurements at the NMISA revisited. Appl Radiat Isot. 2010;68:1529-33 pubmed publisher
    ..The latest results are presented and discussed, particularly with regard to a quantitative study into which vial type is better suited to obtaining accurate (55)Fe activity measurements...
  27. Gonzalez H, Mendoza C, Viteri F. Absorption of unlabeled reduced iron of small particle size from a commercial source. A method to predict absorption of unlabeled iron compounds in humans. Arch Latinoam Nutr. 2001;51:217-24 pubmed
    ..The use of this method for measuring absorption of unlabeled iron compounds is discussed...
  28. Babusiak M, Man P, Sutak R, Petrak J, Vyoral D. Identification of heme binding protein complexes in murine erythroleukemic cells: study by a novel two-dimensional native separation -- liquid chromatography and electrophoresis. Proteomics. 2005;5:340-50 pubmed
    ..Thirty-three individual proteins were identified and attributed to four novel multiprotein complexes representing four different 'snapshots' of cellular events involved in hemoglobin biosynthesis...
  29. Rola R, Otsuka S, Obenaus A, Nelson G, Limoli C, VandenBerg S, et al. Indicators of hippocampal neurogenesis are altered by 56Fe-particle irradiation in a dose-dependent manner. Radiat Res. 2004;162:442-6 pubmed
    ..The present data provide the first evidence that high-LET radiation has deleterious effects on cells associated with hippocampal neurogenesis...
  30. Qian Z, Xiao D, Tang P, Yao F, Liao Q. Increased expression of transferrin receptor on membrane of erythroblasts in strenuously exercised rats. J Appl Physiol (1985). 1999;87:523-9 pubmed
    ..The increase in TfR expression and cellular Fe accumulation, as well as the decreased serum Fe concentration and nonheme Fe in the liver and the spleen induced by exercise, probably represented the early signs of Fe deficiency...
  31. Chekli L, Brunetti G, Marzouk E, Maoz Shen A, Smith E, Naidu R, et al. Evaluating the mobility of polymer-stabilised zero-valent iron nanoparticles and their potential to co-transport contaminants in intact soil cores. Environ Pollut. 2016;216:636-645 pubmed publisher
    ..The resulting database could then be used to develop and validate modelling of nZVI-facilitated contaminant transport on an individual soil basis suitable for site specific risk assessment prior to nZVI remediation. ..
  32. Parsa B, Henitz J, Carter J. Rapid screening and analysis of alpha- and gamma-emitting radionuclides in liquids using a single sample preparation procedure. Health Phys. 2011;100:152-9 pubmed publisher
    ..It has been shown that fission products could potentially be captured and analyzed by this method...
  33. Thompson K, Molina R, Donaghey T, Brain J, Wessling Resnick M. Iron absorption by Belgrade rat pups during lactation. Am J Physiol Gastrointest Liver Physiol. 2007;293:G640-4 pubmed
    ..Tissue (59)Fe levels were also lower in b/b rats postgavage. Combined, these data suggest that DMT1 function is not essential for iron assimilation from milk during early development in the rat...
  34. Huang X, Thiessen J, Spino M, Templeton D. Transport of iron chelators and chelates across MDCK cell monolayers: implications for iron excretion during chelation therapy. Int J Hematol. 2010;91:401-12 pubmed publisher
    ..Further studies are warranted to determine if these processes may contribute to the observed nephrotoxicity of some iron chelators...
  35. Bedard Y, Pinkerton P, Simon G. Uptake of circulating iron by the duodenum of normal mice and mice with altered iron stores, including sex-linked anemia: high resolution radioautographic study. Lab Invest. 1976;34:611-5 pubmed
    ..In either event, the result would be that the absorptive cell receives an inappropriate message with resulting inappropriate absorption of iron...
  36. Gordon M, Lewis J, Marley S. Of mice and men...and elephants. Blood. 2002;100:4679-80 pubmed
  37. Schümann K, Szegner B, Kohler B, Pfaffl M, Ettle T. A method to assess 59Fe in residual tissue blood content in mice and its use to correct 59Fe-distribution kinetics accordingly. Toxicology. 2007;241:19-32 pubmed
    ..To investigate the molecular mechanisms of iron homeostasis, corresponding essential genes are manipulated by many working groups. This asks for a simple method to pursue the resulting impact on body iron-distribution in mice...
  38. Killmann H, Gestwa G. Determination of ferrichrome binding to the FhuA outer membrane transport protein, periplasmic accumulation of ferrichrome, or transport of ferrichrome into cells using a three-layer oil technique. Anal Biochem. 2002;310:55-60 pubmed
    ..Similar transport rates were obtained with the two methods, but binding of ferrichrome to the mutated FhuA proteins and accumulation of ferrichrome in the periplasm could be measured only with the new method...
  39. Lenarczyk M, Ueno A, Vannais D, Kraemer S, Kronenberg A, Roberts J, et al. The "pro-drug" RibCys decreases the mutagenicity of high-LET radiation in cultured mammalian cells. Radiat Res. 2003;160:579-83 pubmed
  40. Lahiri S, Sarkar S. Separation of iron and cobalt using 59Fe and 60Co by dialysis of polyvinylpyrrolidone-metal complexes: a greener approach. Appl Radiat Isot. 2007;65:387-91 pubmed
    ..The optimum condition for separation has been obtained at pH 5 using 10% aqueous solution of PVP. The method is applicable from trace scale to macro-scale. Very high separation factors have been obtained...
  41. Gargari B, Razavieh S, Mahboob S, Niknafs B, Kooshavar H. Effect of retinol on iron bioavailability from Iranian bread in a Caco-2 cell culture model. Nutrition. 2006;22:638-44 pubmed
    ..In addition, interaction of vitamin A with iron bioavailability is not well documented, so we determined iron bioavailability from the most widely consumed food in Iran, lavash bread, and the effect of vitamin A on this bioavailability...
  42. Tweedle M. Using radiotracers to characterize magnetic resonance imaging contrast agents. Invest Radiol. 2002;37:107-13 pubmed
  43. Lombi E, Tearall K, Howarth J, Zhao F, Hawkesford M, McGrath S. Influence of iron status on cadmium and zinc uptake by different ecotypes of the hyperaccumulator Thlaspi caerulescens. Plant Physiol. 2002;128:1359-67 pubmed
    ..The present results indicate that the stimulatory effect of Fe deficiency on Cd uptake in Ganges may be related to an up-regulation in the expression of genes encoding for Fe(2+) uptake, possibly TcIRT1-G...
  44. Asgharian B, Kelly J, Tewksbury E. Respiratory deposition and inhalability of monodisperse aerosols in Long-Evans rats. Toxicol Sci. 2003;71:104-11 pubmed
    ..The deposition results will improve the database on particle deposition in the lung airways of rats, and inhalability information will improve the accuracy of rat-to-human data extrapolation...
  45. Plaha D, Rogers H. Effect of osmotic shock and shearing forces on ferric enterochelin transport in Escherichia coli K12. J Gen Microbiol. 1987;133:1227-34 pubmed
    ..Such changes may enhance survival following physicochemical stressing of the bacterial outer membrane...
  46. Richardson D. Mobilization of iron from neoplastic cells by some iron chelators is an energy-dependent process. Biochim Biophys Acta. 1997;1320:45-57 pubmed
    ..Further studies investigating the membrane transport of Fe chelators may be useful in designing regimes that potentiate their anti-neoplastic effects...
  47. Moroo I, Ujiie M, Walker B, Tiong J, Vitalis T, Karkan D, et al. Identification of a novel route of iron transcytosis across the mammalian blood-brain barrier. Microcirculation. 2003;10:457-62 pubmed
  48. Anderson J, Harper J, Cucinotta F, O Neill P. Participation of DNA-PKcs in DSB repair after exposure to high- and low-LET radiation. Radiat Res. 2010;174:195-205 pubmed publisher
  49. Wareing M, Ferguson C, Green R, Riccardi D, Smith C. In vivo characterization of renal iron transport in the anaesthetized rat. J Physiol. 2000;524 Pt 2:581-6 pubmed
    ..However, this pathway may not be shared by zinc...
  50. Danzeisen R, Ponnambalam S, Lea R, Page K, Gambling L, McArdle H. The effect of ceruloplasmin on iron release from placental (BeWo) cells; evidence for an endogenous Cu oxidase. Placenta. 2000;21:805-12 pubmed
    ..We propose that this oxidase performs the same function as serum ceruloplasmin and is involved in iron release into the fetal circulation...
  51. Buckett P, Wessling Resnick M. Small molecule inhibitors of divalent metal transporter-1. Am J Physiol Gastrointest Liver Physiol. 2009;296:G798-804 pubmed publisher
    ..This study characterizes important pharmacological tools that can be used to probe DMT1's mechanism of iron transport and its role in iron metabolism. ..
  52. Qian Z, Tsoi Y, Ke Y, Wong M. Ceruloplasmin promotes iron uptake rather than release in BT325 cells. Exp Brain Res. 2001;140:369-74 pubmed
    ..These results showed that CP had a role in iron uptake rather than release in BT325 cells...
  53. Olivares M, Pizarro F, Ruz M. New insights about iron bioavailability inhibition by zinc. Nutrition. 2007;23:292-5 pubmed
    ..We measured the effects of lower and higher doses of zinc (Zn) given as an aqueous solution on the bioavailability of iron (Fe)...