iodine isotopes

Summary

Summary: Stable iodine atoms that have the same atomic number as the element iodine, but differ in atomic weight. I-127 is the only naturally occurring stable iodine isotope.

Top Publications

  1. Butowt R, Davies P, Brown D. Anterograde axonal transport of chicken cellular prion protein (PrPc) in vivo requires its N-terminal part. J Neurosci Res. 2007;85:2567-79 pubmed
    ..These data indicate that the N-terminal half of chicken PrP(c) contains the necessary information to drive the internalization and subsequent sorting of extracellular PrP(c) in RGCs soma into the anterograde axonal transport pathway...
  2. Tamim M, Samadi P, Morissette M, Gregoire L, Ouattara B, Levesque D, et al. Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides. Neuropharmacology. 2010;58:286-96 pubmed publisher
    ..These results show that drugs displaying a wide range of pharmacological activities can modulate L-DOPA induced dyskinesias and this activity is correlated with striatal PPD and PPE mRNA levels suggesting a convergent mechanism...
  3. Simmons M, Sobotka Briner C, Medd A. Localization and function of NK(3) subtype tachykinin receptors of layer V pyramidal neurons of the guinea-pig medial prefrontal cortex. Neuroscience. 2008;156:987-94 pubmed publisher
    ..In layer V pyramidal neurons of the medial prefrontal cortex, activation of the NK(3) receptor system plays an excitatory role in modulating synaptic transmission...
  4. Lo Gerfo P, Herter F, Braun J, Hansen H. Tumor associated antigen with pulmonary neoplasms. Ann Surg. 1972;175:495-500 pubmed
  5. Zhao Z, Xiang Z, Haroutunian V, Buxbaum J, Stetka B, Pasinetti G. Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease. Neurobiol Aging. 2007;28:824-30 pubmed
  6. Wu G, Dong S. High-field 127I NMR of solid sheelite structures: periodates revisited. Solid State Nucl Magn Reson. 2001;20:100-7 pubmed
    ..Segel and H. M. Vyas, 1980, J. Chem. Phys. 72, 1406), we found that the 127I chemical shift anisotropy is negligibly small in sheelite periodates. A small but definite 127I chemical shift tensor was observed for pseudo-scheelite CsIO4...
  7. Yang Y, Yao W, Yeh T, Lee I, Chen P, Lu R, et al. Decreased dopamine transporter availability in male smokers -- a dual isotope SPECT study. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:274-9 pubmed
    ..To delineate the role of tobacco addiction in central pre- and post-synaptic dopaminergic activities, we analyzed the central D2-family receptors, the dopamine transporters (DAT), and degrees of dependence in male smokers...
  8. Moore E, Bejta F, Avella M, Suckling K, Botham K. Efflux of lipid from macrophages after induction of lipid accumulation by chylomicron remnants. Biochim Biophys Acta. 2005;1735:20-9 pubmed
    ..These results suggest that cholesterol and triacylglycerol derived from chylomicron remnants are not readily cleared from macrophages, and this is likely to contribute to the atherogenicity of the remnant lipoproteins...
  9. Park E, Chi S, Park D. Activity-dependent modulation of the interaction between CaMKII? and Abi1 and its involvement in spine maturation. J Neurosci. 2012;32:13177-88 pubmed
    ..Our results suggest that modulation of the interaction between Abi1 and CaMKII?, through the glutamate receptor pathway, may be a molecular mechanism underlying activity-regulated structural plasticity in rat hippocamapal neurons...

More Information

Publications62

  1. Delorme R, Betancur C, Callebert J, Chabane N, Laplanche J, Mouren Simeoni M, et al. Platelet serotonergic markers as endophenotypes for obsessive-compulsive disorder. Neuropsychopharmacology. 2005;30:1539-47 pubmed
    ..These alterations may serve as endophenotypic markers in OCD, and could contribute to the study of the biological mechanisms and genetic underpinnings of the disorder...
  2. Hellier J, Arevalo N, Blatner M, Dang A, Clevenger A, Adams C, et al. Olfactory discrimination varies in mice with different levels of ?7-nicotinic acetylcholine receptor expression. Brain Res. 2010;1358:140-50 pubmed publisher
    ..These data suggest that ?7-nicotinic-receptors contribute strongly to olfactory discrimination and detection in mice and may be one of the mechanisms producing olfactory dysfunction in schizophrenics...
  3. Catarzi D, Varano F, Filacchioni G, Martini C, Trincavelli L, Lucacchini A, et al. Synthesis and structure-activity relationships of 4-cycloalkylamino-1, 2, 4-triazolo[4, 3-a]quinoxalin-1- one derivatives as A1 and A3 adenosine receptor antagonists. Arch Pharm (Weinheim). 2004;337:35-41 pubmed
    ..Finally, SAR studies provide some new insights about the steric requirements of the A(3) receptor pocket, which accommodates the benzofused moiety of our 4-amino-triazoloquinoxalin-1-one derivatives...
  4. Mizuno T, Kondo M, Ishigami N, Tamura A, Itsukage M, Koizumi H, et al. Cognitive impairment and cerebral hypoperfusion in a CADASIL patient improved during administration of lomerizine. Clin Neuropharmacol. 2009;32:113-6 pubmed publisher
    ..Cognitive decline and cerebral hypoperfusion improved during 2-year administration of lomerizine in this CADASIL patient, and thus, lomerizine is a potential candidate for treating cognitive impairment in CADASIL patients...
  5. Masana M, Soares J, Dubocovich M. 17Beta-estradiol modulates hMT1 melatonin receptor function. Neuroendocrinology. 2005;81:87-95 pubmed
    ..We suggest that 17beta-estradiol differentially affects MT1 and MT2 melatonin receptor functions, attenuates melatonin responses through activation of MT1 receptors, and increases the MT2 receptors density...
  6. Lima L, Barros I, Lisboa P, Araujo R, Silva A, Rosenthal D, et al. Estrogen effects on thyroid iodide uptake and thyroperoxidase activity in normal and ovariectomized rats. Steroids. 2006;71:653-9 pubmed
    ..Since serum TSH levels were not significantly changed, we suggest a direct action of estradiol on the thyroid gland, which depends on the age and on the previous gonad status of the animal...
  7. Boksa P, Zhang Y, Amritraj A, Kar S. Birth insults involving hypoxia produce long-term increases in hippocampal [125I]insulin-like growth factor-I and -II receptor binding in the rat. Neuroscience. 2006;139:451-62 pubmed
  8. Hou X, Aldahan A, Nielsen S, Possnert G, Nies H, Hedfors J. Speciation of 129I and 127I in seawater and implications for sources and transport pathways in the North Sea. Environ Sci Technol. 2007;41:5993-9 pubmed
  9. Jones D, Kuhar M. CART receptor binding in primary cell cultures of the rat nucleus accumbens. Synapse. 2008;62:122-7 pubmed
    ..This is the first demonstration of CART peptide receptor binding in primary cell cultures of the rat brain...
  10. Glynn A, Howard C. The sensitivity to complement of strains of Escherichia coli related to their K antigens. Immunology. 1970;18:331-46 pubmed
  11. Lamers R, de Jong A, López Gutiérrez J, Gómez Guzmán J. Iodine-129 microdosing for protein and peptide drug development: erythropoietin as a case study. Bioanalysis. 2013;5:53-63 pubmed publisher
    ..In this study, we investigated whether (129)I-labeling of proteins with subsequent AMS measurements is a suitable method to perform microdose studies with therapeutic proteins. We used erythropoietin (EPO) as a case study...
  12. Ishikawa N, Kobayashi Y, Kobayashi M. A case of frontal lobe epilepsy in which amplitude-integrated EEG combined with conventional EEG was useful for evaluating clusters of seizures. Epilepsy Behav. 2010;18:485-7 pubmed publisher
    ..The combination of aEEG and conventional EEG may be a useful tool in both neonatal intensive care units and epilepsy care units...
  13. Hsuchou H, Kastin A, Tu H, Joan Abbott N, Couraud P, Pan W. Role of astrocytic leptin receptor subtypes on leptin permeation across hCMEC/D3 human brain endothelial cells. J Neurochem. 2010;115:1288-98 pubmed publisher
  14. Yu X, Cao C, Mennicken F, Puma C, Dray A, O Donnell D, et al. Pro-nociceptive effects of neuromedin U in rat. Neuroscience. 2003;120:467-74 pubmed
    ..The restricted distribution of NMU receptors to a region of the spinal cord involved in nociception suggests that this peptide receptor system may play a role in nociception...
  15. Unanue E, Askonas B. The immune response of mice to antigen in macrophages. Immunology. 1968;15:287-96 pubmed
  16. Nielsen R, Sørensen B, Birn H, Christensen E, Nexø E. Transcellular transport of vitamin B(12) in LLC-PK1 renal proximal tubule cells. J Am Soc Nephrol. 2001;12:1099-106 pubmed
    ..This mechanism is likely to play a significant role in the maintenance of B(12) homeostasis by returning filtered B(12) to the pool of circulating vitamin...
  17. Halem H, Taylor J, Dong J, Shen Y, Datta R, Abizaid A, et al. A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain. Neuroendocrinology. 2005;81:339-49 pubmed
  18. Zheng D, Larsson B, Phelps S, Ophir A. Female alternative mating tactics, reproductive success and nonapeptide receptor expression in the social decision-making network. Behav Brain Res. 2013;246:139-47 pubmed publisher
    ..Our data support the hypothesis that neural phenotype for neuromodulatory nonapeptide receptors within the SDM relates to natural behavior associated with reproductive decisions...
  19. Glenthoj B, Mackeprang T, Svarer C, Rasmussen H, Pinborg L, Friberg L, et al. Frontal dopamine D(2/3) receptor binding in drug-naive first-episode schizophrenic patients correlates with positive psychotic symptoms and gender. Biol Psychiatry. 2006;60:621-9 pubmed
    ..The aim of the study was to examine extrastriatal dopamine D(2/3) receptor binding and psychopathology in schizophrenic patients, and to relate binding potential (BP) values to psychopathology...
  20. Leibowitz S, Kennedy L. Cerebral vascular permeability and cellular infiltration in experimental allergic encephalomyelitis. Immunology. 1972;22:859-69 pubmed
  21. Mito Y, Yoshida K, Yabe I, Makino K, Tashiro K, Kikuchi S, et al. Brain SPECT analysis by 3D-SSP and phenotype of Parkinson's disease. J Neurol Sci. 2006;241:67-72 pubmed
    ..We therefore investigated the association of phenotypes in untreated PD with brain perfusion on SPECT using three-dimensional stereotactic surface projection (3D-SSP) technique...
  22. Myers C, Myers J. The outer membrane cytochromes of Shewanella oneidensis MR-1 are lipoproteins. Lett Appl Microbiol. 2004;39:466-70 pubmed publisher
    ..The cell surface exposure of OmcA could allow it to directly transfer electrons to extracellular electron acceptors (e.g. manganese oxides) and is consistent with its in vivo role...
  23. Fidzianska A, Ryniewicz B, Shen X, Engel A. IBM-type inclusions in a patient with slow-channel syndrome caused by a mutation in the AChR epsilon subunit. Neuromuscul Disord. 2005;15:753-9 pubmed
    ..Molecular genetic studies revealed a novel valine to phenylalanine mutation (epsilonV259F) in the M2 domain of the acetylcholine receptor. Coexistence of the slow-channel syndrome with a feature of IBM has not been observed before...
  24. Fish S, Alavi A, Mandel S. I-123 imaging after recombinant human thyroid-stimulating hormone to diagnose metastatic disease in an intubated patient with papillary thyroid cancer. Clin Nucl Med. 2002;27:895 pubmed
  25. Sas Korczyńska B, Dixon B, Skołyszewski J, Lesiak J. [Choroidal metastases of malignancies. Review of treatment methods with special regard to application of radiotherapy]. Klin Oczna. 2006;108:346-52 pubmed
  26. Kanematsu A, Marui A, Yamamoto S, Ozeki M, Hirano Y, Yamamoto M, et al. Type I collagen can function as a reservoir of basic fibroblast growth factor. J Control Release. 2004;99:281-92 pubmed
    ..These results suggest the significance and therapeutic utility of type I collagen as a reservoir of bFGF...
  27. Li J, Cona M, Feng Y, Chen F, Zhang G, Fu X, et al. A single-dose toxicity study on non-radioactive iodinated hypericin for a targeted anticancer therapy in mice. Acta Pharmacol Sin. 2012;33:1549-56 pubmed publisher
    ..In the present study, we examined the toxicity of a single dose of non-radioactive (127)I-Hyp in normal mice for 24 h and 14 d...
  28. Kong M, Zhang J, Jiang C, Jiang X, Li Y, Gao M, et al. Necrosis affinity evaluation of 131I-hypericin in a rat model of induced necrosis. J Drug Target. 2013;21:604-10 pubmed publisher
    ..Therefore, (131)I-labeled Hyp could be a broad-spectrum anti-tumor agent with a cost much cheaper relative to the biological agents such as monoclonal antibodies...
  29. Frost S, Keen K, Levine J, Terasawa E. Microdialysis methods for in vivo neuropeptide measurement in the stalk-median eminence in the Rhesus monkey. J Neurosci Methods. 2008;168:26-34 pubmed
    ..Therefore, the microdialysis method described here is a highly useful tool for neuroendocrine studies in non-human primates...
  30. Cheng X, Yang L, He P, Li R, Shen Y. Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer's disease and non-demented patients. J Alzheimers Dis. 2010;19:621-30 pubmed publisher
    ..01). These studies reveal a novel observation of abnormal TNF receptor activation in AD brains. Differential TNF receptor protein levels and binding affinities suggest distinct pathogenic mechanisms of neurodegeneration in the AD brain...
  31. Hone A, Whiteaker P, Christensen S, Xiao Y, Meyer E, McIntosh J. A novel fluorescent alpha-conotoxin for the study of alpha7 nicotinic acetylcholine receptors. J Neurochem. 2009;111:80-9 pubmed publisher
    ..This labeling could be abolished by pre-treatment with alpha-cobratoxin. Thus, Cy3-ArIB[V11L;V16A] is a novel and selective fluorescent probe for alpha7 receptors...
  32. Mousavi M, Nordberg A. Expression of the alpha7, alpha4 and alpha3 nicotinic receptor subtype in the brain and adrenal medulla of transgenic mice carrying genes coding for human AChE and beta-amyloid. Int J Dev Neurosci. 2006;24:269-73 pubmed
    ..The findings may have implications for a better understanding the underlying mechanism for AD-related pathogenesis...
  33. Smith J, Barker C. Antigen release from insoluble polymer complexes by lymphocyte cell suspensions. Clin Exp Immunol. 1971;9:869-77 pubmed
  34. Pimlott S, Piggott M, Owens J, Greally E, Court J, Jaros E, et al. Nicotinic acetylcholine receptor distribution in Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease, and vascular dementia: in vitro binding study using 5-[(125)i]-a-85380. Neuropsychopharmacology. 2004;29:108-16 pubmed
  35. Anderson R, Walford R. DIRECT DEMONSTARTION OF A, B, AND RH DEGREES (D) BLOOD GROUP ANTIGENS ON HUMAN LEUKOCYTES. Am J Clin Pathol. 1963;40:239-42 pubmed
  36. Gatzinsky K, Thrasivoulou C, Campioni Noack M, Underwood C, Cowen T. The role of NGF uptake in selective vulnerability to cell death in ageing sympathetic neurons. Eur J Neurosci. 2004;20:2848-56 pubmed
    ..We conclude that vulnerability to, or protection from, age-related neurodegeneration and neuronal cell death are associated with life-long low, or high, levels of NGF uptake, respectively...
  37. Atassi M, Childress C. Immunogenicity of heme complexes of peptides designed to mimic the heme environment of myoglobin and hemoglobin. Protein J. 2005;24:51-6 pubmed
    ..However these heme-peptides were non-immunogenic when administered in PBS intravenously. It is concluded that heme-peptides:(a) would not trigger an adverse immune response if used for transfusion purposes...
  38. Koga H, Izawa I, Araki N, Saya H, Mimori T. Observation of the intracellular behavior of recombinant Yersinia pseudotuberculosis invasin protein. Microbiol Immunol. 2005;49:297-302 pubmed
    ..From these observations, we concluded that our bacterial-free system is able to analyze the action of invasin for Yersinia pseudotuberculosis entry...
  39. Banks W, Robinson S, Diaz Espinoza R, Urayama A, Soto C. Transport of prion protein across the blood-brain barrier. Exp Neurol. 2009;218:162-7 pubmed publisher
    ..These results show that PrP(c) has bidirectional, saturable transport across the BBB and selectively targets some CNS regions. Such transport may play a role in PrP(c) function and prion replication...
  40. Brailoiu E, Dun S, Gao X, Brailoiu G, Li J, Luo J, et al. C-peptide of preproinsulin-like peptide 7: localization in the rat brain and activity in vitro. Neuroscience. 2009;159:492-500 pubmed
    ..Collectively, our result raises the possibility that C-INSL7 acts as a signaling molecule independent from INSL7 in the rat CNS...
  41. Palmer B, Zarroug A, Poley R, Kollars J, Moir C. Papillary thyroid carcinoma in children: risk factors and complications of disease recurrence. J Pediatr Surg. 2005;40:1284-8 pubmed
    ..Optimal treatment of recurrent papillary thyroid carcinoma (PTC) in children remains controversial. We reviewed our experience with recurrent PTC to better identify children diagnosed with it...
  42. Nosrat I, Smith C, Mullally P, Olson L, Nosrat C. Dental pulp cells provide neurotrophic support for dopaminergic neurons and differentiate into neurons in vitro; implications for tissue engineering and repair in the nervous system. Eur J Neurosci. 2004;19:2388-98 pubmed
  43. Santschi P, Schwehr K. 129I/(127)I as a new environmental tracer or geochronometer for biogeochemical or hydrodynamic processes in the hydrosphere and geosphere: the central role of organo-iodine. Sci Total Environ. 2004;321:257-71 pubmed
    ..of the short-term and long-term dose from accidental releases and fallout from atomic bomb tests was from iodine isotopes. (2) (129)I is one of the two long-lived nuclides with highest mobility in stored radioactive waste...
  44. Rieck R, Ansari M, Whetsell W, Deutch A, Kessler R. Distribution of dopamine D2-like receptors in the human thalamus: autoradiographic and PET studies. Neuropsychopharmacology. 2004;29:362-72 pubmed
  45. Pagel J, Appelbaum F, Eary J, Rajendran J, Fisher D, Gooley T, et al. 131I-anti-CD45 antibody plus busulfan and cyclophosphamide before allogeneic hematopoietic cell transplantation for treatment of acute myeloid leukemia in first remission. Blood. 2006;107:2184-91 pubmed
    ..39-1.08; P = .09). The addition of targeted hematopoietic irradiation to conventional BU/CY is feasible and well tolerated, and phase 2 results are sufficiently encouraging to warrant further study...
  46. Yoshikawa K, Hatate J, Toratani N, Sugiura S, Shimizu Y, Takahash T, et al. Prevalence of Sjögren's syndrome with dementia in a memory clinic. J Neurol Sci. 2012;322:217-21 pubmed publisher
    ..Sjögren's syndrome (SS) is an autoimmune disorder involving the exocrine glands, which affects 1.9-3.0% of the elderly population. Approximately 20% of all patients with SS have CNS involvement, including dementia, as a result of angiitis...
  47. Pan W, Ding Y, Yu Y, Ohtaki H, Nakamachi T, Kastin A. Stroke upregulates TNFalpha transport across the blood-brain barrier. Exp Neurol. 2006;198:222-33 pubmed
    ..Given the known multiple modulatory effects of TNFalpha after stroke, the results indicate that the TNFalpha transport system at the BBB facilitates neuroplasticity and plays an important role in stroke recovery...
  48. Kesminiene A, Evrard A, Ivanov V, Malakhova I, Kurtinaitise J, Stengrevics A, et al. Risk of thyroid cancer among chernobyl liquidators. Radiat Res. 2012;178:425-36 pubmed publisher
    ..Although recall bias and uncertainties in doses could have affected the magnitude of the risk estimates, the findings of this study contribute to a better characterization the risk of thyroid cancer after radiation exposure in adulthood...
  49. Meigooni A, Hayes J, Zhang H, Sowards K. Experimental and theoretical determination of dosimetric characteristics of IsoAid ADVANTAGE 125I brachytherapy source. Med Phys. 2002;29:2152-8 pubmed
    ..97 +/- 0.03. The dosimetric characteristics of this new source compared favorably with those from the Amersham Health Model 6711 source. Complete dosimetric parameters of the new source are presented in this paper...
  50. Hoyer L, Trabold N. The significance of erythrocyte antigen site density. I. Hemagglutination. J Clin Invest. 1970;49:87-95 pubmed
    ..They are consistent with the hypothesis that those blood group antigens which have a very low site number will not be detected by IgG antibodies in saline hemagglutination determinations...
  51. Rodbell M, Birnbaumer L, Pohl S, Sundby F. The reaction of glucagon with its receptor: evidence for discrete regions of activity and binding in the glucagon molecule. Proc Natl Acad Sci U S A. 1971;68:909-13 pubmed
  52. Castelán F, Mulet J, Aldea M, Sala S, Sala F, Criado M. Cytoplasmic regions adjacent to the M3 and M4 transmembrane segments influence expression and function of alpha7 nicotinic acetylcholine receptors. A study with single amino acid mutants. J Neurochem. 2007;100:406-15 pubmed
    ..These results suggest that the cytoplasmic regions close to M3 and M4 play important structural and functional roles...
  53. Kobylecki C, Crossman A, Ravenscroft P. Alternative splicing of AMPA receptor subunits in the 6-OHDA-lesioned rat model of Parkinson's disease and L-DOPA-induced dyskinesia. Exp Neurol. 2013;247:476-84 pubmed publisher
    ..Increases in GluR2-flip expression depend on activation of Ca(2+)-permeable AMPA receptors, which are a potential target of anti-dyskinetic therapies...