dietary iron

Summary

Summary: Iron or iron compounds used in foods or as food. Dietary iron is important in oxygen transport and the synthesis of the iron-porphyrin proteins hemoglobin, myoglobin, cytochromes, and cytochrome oxidase. Insufficient amounts of dietary iron can lead to iron-deficiency anemia.

Top Publications

  1. Ziv K, Meir G, Harmelin A, Shimoni E, Klein E, Neeman M. Ferritin as a reporter gene for MRI: chronic liver over expression of H-ferritin during dietary iron supplementation and aging. NMR Biomed. 2010;23:523-31 pubmed publisher
    ..Furthermore, dietary iron supplementation significantly affected MRI contrast, without affecting animal wellbeing, for both wildtype and ..
  2. Hansen S, Ashwell M, Moeser A, Fry R, Knutson M, Spears J. High dietary iron reduces transporters involved in iron and manganese metabolism and increases intestinal permeability in calves. J Dairy Sci. 2010;93:656-65 pubmed publisher
    ..Additionally, reduced levels of DMT1 protein appeared to decrease duodenal Mn, suggesting that Mn may also be a substrate for DMT1 in cattle...
  3. Kallianpur A, Lee S, Xu W, Zheng W, Gao Y, Cai H, et al. Dietary iron intake and risk of endometrial cancer: a population-based case-control study in Shanghai, China. Nutr Cancer. 2010;62:40-50 pubmed publisher
    ..Animal-derived iron intake is associated with increased risk of EC after menopause and among obese women. Avoidance of animal-derived (heme) iron may reduce the risk of EC in these women...
  4. Sachdev H, Gera T, Nestel P. Effect of iron supplementation on physical growth in children: systematic review of randomised controlled trials. Public Health Nutr. 2006;9:904-20 pubmed
    ..To evaluate the effect of iron supplementation on physical growth in children through a systematic review of randomised controlled trials (RCTs)...
  5. Kallianpur A, Lee S, Gao Y, Lu W, Zheng Y, Ruan Z, et al. Dietary animal-derived iron and fat intake and breast cancer risk in the Shanghai Breast Cancer Study. Breast Cancer Res Treat. 2008;107:123-32 pubmed
    ..Iron, an essential micronutrient with pro-oxidant properties, has received little attention, and specific fats may augment its toxicity. We investigated the effects of iron and fats from various food sources on the risk of breast cancer...
  6. Sumida Y, Kanemasa K, Fukumoto K, Yoshida N, Sakai K. Effects of dietary iron reduction versus phlebotomy in patients with chronic hepatitis C: results from a randomized, controlled trial on 40 Japanese patients. Intern Med. 2007;46:637-42 pubmed
    Iron may play an important role in the pathogenesis of hepatitis C. We conducted this randomized, controlled trial comparing phlebotomy with dietary iron reduction.
  7. Kew M, Asare G. Dietary iron overload in the African and hepatocellular carcinoma. Liver Int. 2007;27:735-41 pubmed
    b>Dietary iron overload occurs commonly in parts of sub-Saharan Africa. It results from the consumption of large volumes of traditional beer that is home-brewed in iron pots or drums and consequently has a high iron content...
  8. Asakura K, Sasaki S, Murakami K, Takahashi Y, Uenishi K, Yamakawa M, et al. Iron intake does not significantly correlate with iron deficiency among young Japanese women: a cross-sectional study. Public Health Nutr. 2009;12:1373-83 pubmed publisher
    ..Uniquely among developed countries, dietary habits render Japanese populations vulnerable to Fe deficiency, owing to their relatively low intake of Fe and high intake of Fe absorption inhibitors, such as green tea and soyabeans...
  9. Tzoulaki I, Brown I, Chan Q, Van Horn L, Ueshima H, Zhao L, et al. Relation of iron and red meat intake to blood pressure: cross sectional epidemiological study. BMJ. 2008;337:a258 pubmed publisher
    To investigate associations of dietary iron (total, haem, and non-haem), supplemental iron, and red meat with blood pressure.

More Information

Publications62

  1. Tavani A, Gallus S, Bosetti C, Parpinel M, Negri E, La Vecchia C. Dietary iron intake and risk of non-fatal acute myocardial infarction. Public Health Nutr. 2006;9:480-4 pubmed
    ..This is of specific interest since iron is frequently included in supplementation and fortification of foods. We assessed the relation between dietary iron intake and the risk of non-fatal AMI.
  2. Katsumata S, Tsuboi R, Uehara M, Suzuki K. Dietary iron deficiency decreases serum osteocalcin concentration and bone mineral density in rats. Biosci Biotechnol Biochem. 2006;70:2547-50 pubmed
    We investigated the effects of dietary iron deficiency on bone metabolism by measuring markers of bone turnover in rats. Twelve 3-week-old male Wistar-strain rats were fed a control diet or an iron-deficient diet for 4 weeks...
  3. Kabat G, Miller A, Jain M, Rohan T. Dietary iron and heme iron intake and risk of breast cancer: a prospective cohort study. Cancer Epidemiol Biomarkers Prev. 2007;16:1306-8 pubmed
    ..Data from a food frequency questionnaire administered at baseline were used to calculate total dietary iron and heme iron intake...
  4. Kabat G, Miller A, Jain M, Rohan T. Dietary iron and haem iron intake and risk of endometrial cancer: a prospective cohort study. Br J Cancer. 2008;98:194-8 pubmed
    ..frequency questionnaire administered at baseline were used to calculate intake of all meats, red meat, total dietary iron, iron from meat, haem iron, and non-haem iron...
  5. Gordeuk V, Moyo V, Nouraie M, Gangaidzo I, Murphree N, Gomo Z, et al. Circulating cytokines in pulmonary tuberculosis according to HIV status and dietary iron content. Int J Tuberc Lung Dis. 2009;13:1267-73 pubmed
    To evaluate human immunodeficiency virus (HIV) serology, dietary iron and serum concentrations of markers of T-helper type (Th) 1 and Th-2 immune pathways in the setting of tuberculosis (TB).
  6. Craig P, Galus M, Wood C, McClelland G. Dietary iron alters waterborne copper-induced gene expression in soft water acclimated zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2009;296:R362-73 pubmed publisher
    ..This study shows that high dietary Fe can significantly alter the genetic expression pattern of Cu transporters at the level of the gill, liver, and gastrointestinal tract...
  7. Mesias M, Seiquer I, Muñoz Hoyos A, Galdó G, Navarro M. The beneficial effect of Mediterranean dietary patterns on dietary iron utilization in male adolescents aged 11-14 years. Int J Food Sci Nutr. 2009;60 Suppl 7:355-68 pubmed publisher
    ..b>Dietary iron utilization was studied by means of iron intake and iron output in faeces and urine, and iron status was ..
  8. Moyo V, Mvundura E, Khumalo H, Gangaidzo I, Saungweme T, Nouraie M, et al. Serum ferritin concentrations in Africans with low dietary iron. Ann Hematol. 2009;88:1131-6 pubmed publisher
    In the setting of high dietary, several studies have provided evidence for a strong effect of both high dietary iron and an unidentified genetic locus on iron stores in Africans...
  9. Yehuda S, Rabinovitz S, Carasso R, Mostofsky D. Long-lasting cognitive, physiological and hematological effects in rehabilitated, early dietary iron-deficiency adult rats, and improvement by treatment with a mixture of essential fatty acids. Nutr Neurosci. 2008;11:167-71 pubmed publisher
    ..Treatment with a mixture of essential fatty acids improved their learning capacity...
  10. Zimmermann M, Troesch B, Biebinger R, Egli I, Zeder C, Hurrell R. Plasma hepcidin is a modest predictor of dietary iron bioavailability in humans, whereas oral iron loading, measured by stable-isotope appearance curves, increases plasma hepcidin. Am J Clin Nutr. 2009;90:1280-7 pubmed publisher
    ..Plasma hepcidin appears to be a major regulator of iron absorption and homeostasis, but there are few data in humans...
  11. Aeberli I, Hurrell R, Zimmermann M. Overweight children have higher circulating hepcidin concentrations and lower iron status but have dietary iron intakes and bioavailability comparable with normal weight children. Int J Obes (Lond). 2009;33:1111-7 pubmed publisher
    ..It is possible that overweight individuals may have lower dietary iron intake and/or bioavailability...
  12. Cooksey R, Jones D, Gabrielsen S, Huang J, Simcox J, Luo B, et al. Dietary iron restriction or iron chelation protects from diabetes and loss of beta-cell function in the obese (ob/ob lep-/-) mouse. Am J Physiol Endocrinol Metab. 2010;298:E1236-43 pubmed publisher
    ..5 wk despite no effect on weight. Although dietary iron restriction preserved beta-cell function in ob/ob mice fed a high-fat diet, the effects on overall glucose ..
  13. Kim D, Kim K, Choi B, Youn P, Ryu D, Klaassen C, et al. Regulation of metal transporters by dietary iron, and the relationship between body iron levels and cadmium uptake. Arch Toxicol. 2007;81:327-34 pubmed
    ..Thus, DMT1 and MTP1 may play an important role in not only maintaining Fe levels but also facilitating the accumulation of Cd in the body of mammals...
  14. Brito L, Barreto M, Silva R, Assis A, Reis M, Parraga I, et al. Moderate- and low-intensity co-infections by intestinal helminths and Schistosoma mansoni, dietary iron intake, and anemia in Brazilian children. Am J Trop Med Hyg. 2006;75:939-44 pubmed
    ..4 (95% CI, 1.2-4.6) compared with children with a single parasite species. Children with an adequate intake of iron had no increased odds of anemia independent of the combination of parasite infections...
  15. Jarrah S, Halabi J, Bond A, Abegglen J. Iron deficiency anemia (IDA) perceptions and dietary iron intake among young women and pregnant women in Jordan. J Transcult Nurs. 2007;18:19-27 pubmed
    ..Culturally sensitive intervention research, which addresses application of IDA education principles, temporary supplementation, and adequate income for dietary modification and long-term iron supplementation to prevent IDA is warranted...
  16. Zhao H, Zhu W, Pan T, Xie W, Zhang A, Ondo W, et al. Spinal cord dopamine receptor expression and function in mice with 6-OHDA lesion of the A11 nucleus and dietary iron deprivation. J Neurosci Res. 2007;85:1065-76 pubmed
  17. Kabat G, Miller A, Jain M, Rohan T. A cohort study of dietary iron and heme iron intake and risk of colorectal cancer in women. Br J Cancer. 2007;97:118-22 pubmed
    ..frequency questionnaire administered at baseline were used to calculate red meat intake and intake of total dietary iron, iron from meat, and heme iron...
  18. Dockerty J, Herbison P, Skegg D, Elwood M. Vitamin and mineral supplements in pregnancy and the risk of childhood acute lymphoblastic leukaemia: a case-control study. BMC Public Health. 2007;7:136 pubmed
    ..The present study tested that association...
  19. Elseweidy M, Abd El Baky A. Effect of dietary iron overload in rat brain: oxidative stress, neurotransmitter level and serum metal ion in relation to neurodegenerative disorders. Indian J Exp Biol. 2008;46:855-8 pubmed
    ..Increasing iron level might be responsible for accelerated dopamine oxidation with subsequent quinone formation...
  20. Luan D, Li H, Li S, Zhao Z, Li X, Liu Z. Body iron stores and dietary iron intake in relation to diabetes in adults in North China. Diabetes Care. 2008;31:285-6 pubmed
    To evaluate the association between body iron stores, dietary iron intake, and risk of diabetes in northern China.
  21. Grant W. An ecological study of cancer mortality rates including indices for dietary iron and zinc. Anticancer Res. 2008;28:1955-63 pubmed
    b>Dietary iron and zinc affect the risk of cancer, with dietary iron generally correlated with increased risk and dietary zinc with reduced risk. However, zinc supplements have been found correlated with increased risk of cancer.
  22. Logroscino G, Gao X, Chen H, Wing A, Ascherio A. Dietary iron intake and risk of Parkinson's disease. Am J Epidemiol. 2008;168:1381-8 pubmed publisher
    b>Dietary iron is the most important source of iron stores. Several case-control studies have described the association of high dietary iron and Parkinson's disease, but prospective data are lacking...
  23. Cooper C, Handy R, Bury N. The effects of dietary iron concentration on gastrointestinal and branchial assimilation of both iron and cadmium in zebrafish (Danio rerio). Aquat Toxicol. 2006;79:167-75 pubmed
    ..8-fold induction) of zebrafish fed a low Fe diet. The correlation between Cd uptake and DMT1 expression suggests that one route of uptake of Cd, either from the diet or from the water, could be via DMT1...
  24. Premkumar K, Min K, Alkan Z, Hawkes W, Ebeler S, Bowlus C. The potentiating and protective effects of ascorbate on oxidative stress depend upon the concentration of dietary iron fed C3H mice. J Nutr Biochem. 2007;18:272-8 pubmed
    ..In conclusion, dietary AA appears to have mild pro-oxidant properties at low-iron concentrations but has a strong antioxidant effect against oxidative stress and DNA damage induced by dietary iron in mouse liver.
  25. Hashizume M, Shimoda T, Sasaki S, Kunii O, Caypil W, Dauletbaev D, et al. Anaemia in relation to low bioavailability of dietary iron among school-aged children in the Aral Sea region, Kazakhstan. Int J Food Sci Nutr. 2004;55:37-43 pubmed
    This study investigates anaemia related to the sufficiency of dietary iron intake of school-aged children in the Kzyl-Orda region of Kazakhstan. We conducted a cross-sectional study of 97 school-aged children living in Kzyl-Orda...
  26. Held M, Bungiro R, Harrison L, Hamza I, Cappello M. Dietary iron content mediates hookworm pathogenesis in vivo. Infect Immun. 2006;74:289-95 pubmed
    ..A series of experiments were designed in order to test the hypothesis that host dietary iron restriction mediates susceptibility to hookworm infection using the hamster model of Ancylostoma ceylanicum...
  27. Cade J, Moreton J, O Hara B, Greenwood D, Moor J, Burley V, et al. Diet and genetic factors associated with iron status in middle-aged women. Am J Clin Nutr. 2005;82:813-20 pubmed
    ..Gene mutations associated with iron overload have been identified. How food and nutrient intakes affect iron status in persons who may be at risk of iron overload because their genetic status is unknown...
  28. Jiang R, Ma J, Ascherio A, Stampfer M, Willett W, Hu F. Dietary iron intake and blood donations in relation to risk of type 2 diabetes in men: a prospective cohort study. Am J Clin Nutr. 2004;79:70-5 pubmed
    ..Excessive iron stores may promote insulin resistance and lead to the development of type 2 diabetes. However, prospective data relating iron intake and blood donations (determinants of body iron stores) to diabetes incidence are limited...
  29. Lee D, Folsom A, Jacobs D. Dietary iron intake and Type 2 diabetes incidence in postmenopausal women: the Iowa Women's Health Study. Diabetologia. 2004;47:185-94 pubmed
    Recently, a clear biological link between iron metabolism and diabetes has emerged from epidemiological and experimental studies. We carried out a prospective study of dietary iron intake and incidence of Type 2 diabetes.
  30. Chan A, Ma J, Tranah G, Giovannucci E, Rifai N, Hunter D, et al. Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women. J Natl Cancer Inst. 2005;97:917-26 pubmed
    ..We assessed dietary iron intake and genetic and biochemical markers of iron status in a prospective, nested case-control study of women ..
  31. Waldmann A, Koschizke J, Leitzmann C, Hahn A. Dietary iron intake and iron status of German female vegans: results of the German vegan study. Ann Nutr Metab. 2004;48:103-8 pubmed
    ..As shown in previous studies vegetarians and especially vegans are at risk for iron deficiency. Our study evaluated the iron status of German female vegans...
  32. Mainous A, Wells B, Carek P, Gill J, Geesey M. The mortality risk of elevated serum transferrin saturation and consumption of dietary iron. Ann Fam Med. 2004;2:139-44 pubmed
    ..Because ingestion of dietary iron may contribute to iron overload in persons with elevated transferrin saturation, we investigated the ..
  33. Padhye U. Excess dietary iron is the root cause for increase in childhood autism and allergies. Med Hypotheses. 2003;61:220-2 pubmed
    ..I propose a hypothesis that the excessive dietary iron consumed by today's infants is the root cause of increased cases of Autism, allergies and other childhood ..
  34. Mazur A, Feillet Coudray C, Romier B, Bayle D, Gueux E, Ruivard M, et al. Dietary iron regulates hepatic hepcidin 1 and 2 mRNAs in mice. Metabolism. 2003;52:1229-31 pubmed
    ..The aim of this study was to determine the effects of the level of dietary iron on Hepc gene expression in the liver...
  35. Lomer M, Kodjabashia K, Hutchinson C, Greenfield S, Thompson R, Powell J. Intake of dietary iron is low in patients with Crohn's disease: a case-control study. Br J Nutr. 2004;91:141-8 pubmed
    ..Changing dietary advice may compromise perceived symptoms of the disease so the need for Fe supplementation should be carefully considered...
  36. Foo L, Khor G, Tee E, Prabakaran D. Iron status and dietary iron intake of adolescents from a rural community in Sabah, Malaysia. Asia Pac J Clin Nutr. 2004;13:48-55 pubmed
    ..26.4%, respectively. Iron deficiency anaemia (85.0%) contributed largely to the prevalence of anaemia. The dietary iron intake of the adolescents was unsatisfactory, with approximately 98% of subjects failing to meet the Malaysian ..
  37. Ryu D, Lee S, Park D, Choi B, Klaassen C, Park J. Dietary iron regulates intestinal cadmium absorption through iron transporters in rats. Toxicol Lett. 2004;152:19-25 pubmed
    ..The correlation between duodenal DMT1 and MTP1 expression and Cd body burden in rats suggests an important role of DMT1 and MTP1 in Cd absorption...
  38. Senesse P, Meance S, Cottet V, Faivre J, Boutron Ruault M. High dietary iron and copper and risk of colorectal cancer: a case-control study in Burgundy, France. Nutr Cancer. 2004;49:66-71 pubmed
    ..These findings regarding iron and copper suggest that free radicals play an important role in colorectal carcinogenesis, while the findings regarding vitamin E are so far unexplained...
  39. Ilsley J, Belinsky G, Guda K, Zhang Q, Huang X, Blumberg J, et al. Dietary iron promotes azoxymethane-induced colon tumors in mice. Nutr Cancer. 2004;49:162-9 pubmed
    There is accumulating evidence that high levels of dietary iron may play a role in colon carcinogenesis...
  40. Collins J, Franck C, Kowdley K, Ghishan F. Identification of differentially expressed genes in response to dietary iron deprivation in rat duodenum. Am J Physiol Gastrointest Liver Physiol. 2005;288:G964-71 pubmed
    ..We speculate that dietary iron deprivation leads to increased intestinal copper absorption via DMT1 on the brush-border membrane and the ..
  41. Gunshin H, Starr C, Direnzo C, Fleming M, Jin J, Greer E, et al. Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. Blood. 2005;106:2879-83 pubmed
    Mammalian nonheme iron absorption requires reduction of dietary iron for uptake by the divalent metal ion transport system in the intestine...
  42. Niederkofler V, Salie R, Arber S. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest. 2005;115:2180-6 pubmed
    Iron homeostasis plays a critical role in many physiological processes, notably synthesis of heme proteins. Dietary iron sensing and inflammation converge in the control of iron absorption and retention by regulating the expression of ..
  43. Matsuda Inoguchi N, Shimbo S, Nakatsuka H, Watanabe T, Higashikawa K, Ikeda M. Effects of revision of Japanese food composition tables on estimation of nutrient intakes, with reference to age-dependent differences. Public Health Nutr. 2004;7:901-9 pubmed
    ..To identify effects of revision of the Japanese food composition tables from the fourth version to the fifth version on nutrient intake estimation...
  44. Lind T, Hernell O, Lonnerdal B, Stenlund H, Domellöf M, Persson L. Dietary iron intake is positively associated with hemoglobin concentration during infancy but not during the second year of life. J Nutr. 2004;134:1064-70 pubmed
    ..We wanted to explore the association between dietary iron intake and indicators of iron status, and to assess temporal changes in these variables...
  45. Rincker M, Hill G, Link J, Rowntree J. Effects of dietary iron supplementation on growth performance, hematological status, and whole-body mineral concentrations of nursery pigs. J Anim Sci. 2004;82:3189-97 pubmed
    ..Even so, the lessening of a pig's Fe stores during this rapid growth period may result in the occurrence of anemia during the subsequent grower and finisher periods...
  46. Lee D, Anderson K, Harnack L, Folsom A, Jacobs D. Heme iron, zinc, alcohol consumption, and colon cancer: Iowa Women's Health Study. J Natl Cancer Inst. 2004;96:403-7 pubmed
  47. Larsson S, Adami H, Giovannucci E, Wolk A. Re: Heme iron, zinc, alcohol consumption, and risk of colon cancer. J Natl Cancer Inst. 2005;97:232-3; author reply 233-4 pubmed
  48. Premkumar K, Bowlus C. Ascorbic acid does not increase the oxidative stress induced by dietary iron in C3H mice. J Nutr. 2004;134:435-8 pubmed
    ..High dietary iron increased liver iron concentrations slightly (P < 0...
  49. Zhou S, Schilling M, Makrides M. Evaluation of an iron specific checklist for the assessment of dietary iron intake in pregnant and postpartum women. Nutrition. 2005;21:908-13 pubmed
    This study developed and validated an iron checklist for assessing dietary iron intake of pregnant and postpartum women.
  50. Milman N, Byg K, Bergholt T, Eriksen L. Side effects of oral iron prophylaxis in pregnancy--myth or reality?. Acta Haematol. 2006;115:53-7 pubmed
    ..It is a common belief among women that iron compounds have unpleasant gastrointestinal side effects...
  51. Sautter C, Poletti S, Zhang P, Gruissem W. Biofortification of essential nutritional compounds and trace elements in rice and cassava. Proc Nutr Soc. 2006;65:153-9 pubmed
    ..Current developments in biotechnology-assisted plant improvement are reviewed and the potential of the technology in addressing human nutrition and health are discussed...
  52. Rodrigues P, Pereira F. Effect of dietary iron overload on Photobacterium damselae ssp. piscicida pathogenicity in sea bass, Dicentrarchus labrax (L.). J Fish Dis. 2004;27:673-6 pubmed
  53. Conway R, Geissler C, Hider R, Thompson R, Powell J. Serum iron curves can be used to estimate dietary iron bioavailability in humans. J Nutr. 2006;136:1910-4 pubmed
    ..The main objective of this study was to validate serum Fe curves as measures of dietary iron absorption because previous work demonstrated that serum iron curves can be generated with iron doses as low as ..