technetium

Summary

Summary: The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, and atomic number 43. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.

Top Publications

  1. Varmira K, Hosseinimehr S, Noaparast Z, Abedi S. An improved radiolabelled RNA aptamer molecule for HER2 imaging in cancers. J Drug Target. 2014;22:116-22 pubmed publisher
    ..This study demonstrated EDDA to be better than tricine for use as a co-ligand with the RNA aptamer, which can be a potential tool for the molecular imaging of HER2-overexpressing cancers...
  2. Tzanopoulou S, Sagnou M, Paravatou Petsotas M, Gourni E, Loudos G, Xanthopoulos S, et al. Evaluation of Re and (99m)Tc complexes of 2-(4'-aminophenyl)benzothiazole as potential breast cancer radiopharmaceuticals. J Med Chem. 2010;53:4633-41 pubmed publisher
    ..The results render the 2-(4'-aminophenyl)benzothiazole complexes potential candidates for imaging ((99m)Tc) and targeted radiotherapy ((188)Re) of breast cancer...
  3. Gainkam L, Caveliers V, Devoogdt N, Vanhove C, Xavier C, Boerman O, et al. Localization, mechanism and reduction of renal retention of technetium-99m labeled epidermal growth factor receptor-specific nanobody in mice. Contrast Media Mol Imaging. 2011;6:85-92 pubmed publisher
    ..In this study we have evaluated the role of megalin on the renal uptake of anti-EGFR (99m)Tc-7C12 nanobody and the potency of gelofusine and/or lysine to reduce renal uptake of (99m)Tc-7C12...
  4. Benoist E, Coulais Y, Almant M, Kovensky J, Moreau V, Lesur D, et al. A click procedure with heterogeneous copper to tether technetium-99m chelating agents and rhenium complexes. Evaluation of the chelating properties and biodistribution of the new radiolabelled glucose conjugates. Carbohydr Res. 2011;346:26-34 pubmed publisher
    ..99m)Tc(CO)(3)-glucoconjugates displayed excellent in vitro stability, a fast in vivo blood clearance and a low specific organ uptake or long-term retention in spleen and stomach...
  5. Cheng Y, Ono M, Kimura H, Ueda M, Saji H. Technetium-99m labeled pyridyl benzofuran derivatives as single photon emission computed tomography imaging probes for ?-amyloid plaques in Alzheimer's brains. J Med Chem. 2012;55:2279-86 pubmed publisher
    ..99m)Tc]BAT-Bp-2 may be a potential SPECT probe for imaging ?-amyloid plaques in Alzheimer's brains...
  6. Kattan M, Yu C, Stephenson A, Sartor O, Tombal B. Clinicians versus nomogram: predicting future technetium-99m bone scan positivity in patients with rising prostate-specific antigen after radical prostatectomy for prostate cancer. Urology. 2013;81:956-61 pubmed publisher
    ..To compare the ability of clinicians vs a nomogram at predicting future bone scan positivity in patients with prostate cancer...
  7. Kluba C, Mindt T. Click-to-Chelate: development of technetium and rhenium-tricarbonyl labeled radiopharmaceuticals. Molecules. 2013;18:3206-26 pubmed publisher
    ..approach is a highly efficient strategy for the radiolabeling of molecules of medicinal interest with technetium and rhenium-tricarbonyl cores...
  8. Zhao Y, Zhao S, Kuge Y, Strauss H, Blankenberg F, Tamaki N. Attenuation of apoptosis by telmisartan in atherosclerotic plaques of apolipoprotein E-/- mice: evaluation using technetium 99m-annexin A5. Mol Imaging. 2013;12:300-9 pubmed
    b>Technetium 99m (99mTc)-annexin A5, a marker of ongoing apoptosis, is supposed to be useful in the detection of metabolically active atheroma...
  9. Uhara H, Yamazaki N, Takata M, Inoue Y, Sakakibara A, Nakamura Y, et al. Applicability of radiocolloids, blue dyes and fluorescent indocyanine green to sentinel node biopsy in melanoma. J Dermatol. 2012;39:336-8 pubmed publisher
    ..b>Technetium-99m ((99m)Tc)-tin colloid, (99m)Tc-phytate, 2% patent blue violet (PBV) and 0...

More Information

Publications62

  1. Wållberg H, Orlova A, Altai M, Hosseinimehr S, Widström C, Malmberg J, et al. Molecular design and optimization of 99mTc-labeled recombinant affibody molecules improves their biodistribution and imaging properties. J Nucl Med. 2011;52:461-9 pubmed publisher
    ..However, the renal retention of radioactivity exceeded tumor uptake, which might complicate imaging of metastases in the lumbar region. The aim of this study was to develop an agent with low renal uptake and preserved tumor targeting...
  2. Becerra P, Valdés Vázquez M, Dudhia J, Fiske Jackson A, Neves F, Hartman N, et al. Distribution of injected technetium(99m)-labeled mesenchymal stem cells in horses with naturally occurring tendinopathy. J Orthop Res. 2013;31:1096-102 pubmed publisher
    ..Ten million MSCs, labeled with technetium-99m hexamethylpropyleneamine oxime, were implanted into 13 horses with naturally occurring tendon or ligament ..
  3. Kuhn J, Nochumson J. Operative probe scintimetry with indium and technetium for colorectal cancer. J Surg Oncol. 2007;96:290-6 pubmed
  4. Miot Noirault E, Vidal A, Auzeloux P, Madelmont J, Maublant J, Moins N. First In Vivo SPECT Imaging of Mouse Femorotibial Cartilage Using 99mTc-NTP 15-5. Mol Imaging. 2008;7:263-71 pubmed
    ..This new approach to imaging of cartilage in mice provides joint functionality assessment in vivo, giving a unique opportunity to achieve a greater understanding of cartilage physiology in health and disease...
  5. Pakos E, Trikalinos T, Fotopoulos A, Ioannidis J. Prosthesis infection: diagnosis after total joint arthroplasty with antigranulocyte scintigraphy with 99mTc-labeled monoclonal antibodies--a meta-analysis. Radiology. 2007;242:101-8 pubmed
    ..To perform a meta-analysis of diagnostic studies regarding the accuracy of antigranulocyte scintigraphy (AGS) with monoclonal antibodies in the identification of prosthesis infection after total hip or knee arthroplasty...
  6. Weiss M, Gildehaus F, Brinkbäumer K, Makowski M, Hahn K. [Lymph kinetics with technetium-99m labeled radiopharmaceuticals. Animal studies]. Nuklearmedizin. 2005;44:156-65 pubmed
    Aim of this study was to characterize suitable technetium-99m labeled tracers for lymphoscintigraphy by comparative animal tests.
  7. Pery A, Brochot C, Hoet P, Nemmar A, Bois F. Development of a physiologically based kinetic model for 99m-technetium-labelled carbon nanoparticles inhaled by humans. Inhal Toxicol. 2009;21:1099-107 pubmed publisher
    ..However, their conclusions were conflicting. We developed a physiologically based kinetic model for (99m)technetium-labelled carbon nanoparticles (Technegas). The model was designed to analyse imaging data...
  8. Maset E, Sidhu S, Fisher A, Heydon A, Worsfold P, Cartwright A, et al. Effect of organic co-contaminants on technetium and rhenium speciation and solubility under reducing conditions. Environ Sci Technol. 2006;40:5472-7 pubmed
    ..ReO4- did not undergo reduction, as shown by the constant porewater concentration and the chromatographic data, and thus Re does notfunction as an analogue forTc under environmental nitrate- and iron-reducing conditions...
  9. McMahon S, Young D, Ballok Z, Badaruddin B, Larbpaiboonpong V, Hawdon G. Vascularity of the femoral head after Birmingham hip resurfacing. A technetium Tc 99m bone scan/single photon emission computed tomography study. J Arthroplasty. 2006;21:514-21 pubmed
    ..the vascularity of femoral heads after Birmingham hip resurfacing (BHR), we used a visual scale to assess technetium Tc 99m HDP planar and single photon emission computed tomography bone scans of 36 arthroplasties in 32 ..
  10. Burke I, Boothman C, Lloyd J, Mortimer R, Livens F, Morris K. Effects of progressive anoxia on the solubility of technetium in sediments. Environ Sci Technol. 2005;39:4109-16 pubmed
    b>Technetium is a significant radioactive contaminant from nuclear fuel cycle operations. It is highly mobile in its oxic form (as Tc(VII)O4-) but is scavenged to sediments in its reduced forms (predominantly Tc(IV))...
  11. Kosuda S, Tomita H, Hayashi K, Kita T, Koike K, Arai T. Questionnaire survey of hospitals in Saitama Prefecture regarding the shortage of 99mTc-labeled radiopharmaceuticals and 99Mo/99mTc generators. Ann Nucl Med. 2010;24:319-23 pubmed publisher
    ..6%) replied...
  12. Pitcairn G, Reader S, Pavia D, Newman S. Deposition of corticosteroid aerosol in the human lung by Respimat Soft Mist inhaler compared to deposition by metered dose inhaler or by Turbuhaler dry powder inhaler. J Aerosol Med. 2005;18:264-72 pubmed
    ..The results of this study showed that Respimat SMI deposited corticosteroid more efficiently in the lungs than either of two widely used inhaler devices, Turbuhaler DPI or Becloforte pMDI...
  13. Iyengar K, Vinjamuri S. Role of 99mTc Sulesomab in the diagnosis of prosthetic joint infections. Nucl Med Commun. 2005;26:489-96 pubmed
    ..Investigation of suspected infection in prosthetic joint replacements is a difficult orthopaedic problem with important therapeutic implications...
  14. Banerjee T, Singh A, Sharma R, Maitra A. Labeling efficiency and biodistribution of Technetium-99m labeled nanoparticles: interference by colloidal tin oxide particles. Int J Pharm. 2005;289:189-95 pubmed
    The interference of colloidal tin oxides on the biodistribution of (99m)Technetium radiolabeled chitosan nanoparticles has been overcome by using sodium borohydride instead of commonly used stannous salts as reducing agent for the ..
  15. Visentin R, Pasut G, Veronese F, Mazzi U. Highly efficient technetium-99m labeling procedure based on the conjugation of N-[N-(3-diphenylphosphinopropionyl)glycyl]cysteine ligand with poly(ethylene glycol). Bioconjug Chem. 2004;15:1046-54 pubmed
    ..in micelles, which catalyze the metal reduction by means of an electron pair transfer from the phosphorus to technetium. The [(99m)TcO](3+) species is then coordinated, and at micelle level, both the (P)ON(2)S and the PN(2)S ..
  16. Aloj L, Panico M, Caraco C, Del Vecchio S, Arra C, Affuso A, et al. In vitro and in vivo characterization of Indium-111 and Technetium-99m labeled CCK-8 derivatives for CCK-B receptor imaging. Cancer Biother Radiopharm. 2004;19:93-8 pubmed
    ..The rapid clearance and lower background obtained with 111In-DTPAGlu-G-CCK8 make this a better candidate for further development...
  17. Abiraj K, Mansi R, Tamma M, Forrer F, Cescato R, Reubi J, et al. Tetraamine-derived bifunctional chelators for technetium-99m labelling: synthesis, bioconjugation and evaluation as targeted SPECT imaging probes for GRP-receptor-positive tumours. Chemistry. 2010;16:2115-24 pubmed publisher
    ..The promising preclinical results of (99m)Tc-N4-BB-ANT warrant its potential candidature for clinical translation...
  18. Rouzet F, Dominguez Hernandez M, Hervatin F, Sarda Mantel L, Lefort A, Duval X, et al. Technetium 99m-labeled annexin V scintigraphy of platelet activation in vegetations of experimental endocarditis. Circulation. 2008;117:781-9 pubmed publisher
    ..activity is enhanced by bacterial colonization, we investigated the ability of annexin V labeled with technetium Tc 99m (99mTc-ANX) to provide functional imaging of these vegetations in experimental models of infective ..
  19. von Guggenberg E, Sallegger W, Helbok A, Ocak M, King R, Mather S, et al. Cyclic minigastrin analogues for gastrin receptor scintigraphy with technetium-99m: preclinical evaluation. J Med Chem. 2009;52:4786-93 pubmed publisher
    ..i. for both 99mTc-EDDA-HYNIC-cyclo-MG1 and 99mTc-EDDA-HYNIC-cyclo-MG2. In an imaging study with 99mTc-EDDA-HYNIC-cyclo-MG1, the tumor was clearly visualized. The metabolite analysis indicated rapid enzymatic degradation in vivo...
  20. Banerjee S, Foss C, Castanares M, Mease R, Byun Y, Fox J, et al. Synthesis and evaluation of technetium-99m- and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA). J Med Chem. 2008;51:4504-17 pubmed publisher
    ..PSMA can accommodate the steric requirements of (99m)Tc/Re complexes within PSMA inhibitors, the best results achieved with a linker moiety between the epsilon amine of the urea lysine and the chelator...
  21. Schillaci O, Spanu A, Tagliabue L, Filippi L, Danieli R, Palumbo B, et al. SPECT/CT with a hybrid imaging system in the study of lower gastrointestinal bleeding with technetium-99m red blood cells. Q J Nucl Med Mol Imaging. 2009;53:281-9 pubmed
  22. Petretta M, Soricelli A, Storto G, Cuocolo A. Assessment of coronary flow reserve using single photon emission computed tomography with technetium 99m-labeled tracers. J Nucl Cardiol. 2008;15:456-65 pubmed publisher
    ..On the other hand, technetium 99m-labeled tracers have been largely used for the evaluation of myocardial perfusion with single photon ..
  23. Müller C, Forrer F, Schibli R, Krenning E, de Jong M. SPECT study of folate receptor-positive malignant and normal tissues in mice using a novel 99mTc-radiofolate. J Nucl Med. 2008;49:310-7 pubmed publisher
    ..In this study SPECT/CT of FR-positive malignant and normal tissues and organs in mice was performed using an improved organometallic (99m)Tc-radiofolate...
  24. Lin K, Luu A, Baidoo K, Hashemzadeh Gargari H, Chen M, Pili R, et al. A new high affinity technetium analogue of bombesin containing DTPA as a pharmacokinetic modifier. Bioconjug Chem. 2004;15:1416-23 pubmed
    ..Thus, [DTPA(1), Lys(3)((99m)Tc-Hx-DADT), Tyr(4)]BN has the potential for imaging BN/GRP receptor-positive lesions...
  25. Istok J, Senko J, Krumholz L, Watson D, Bogle M, Peacock A, et al. In situ bioreduction of technetium and uranium in a nitrate-contaminated aquifer. Environ Sci Technol. 2004;38:468-75 pubmed
    ..g., Geobacter). The results demonstrate that it is possible to stimulate the simultaneous bioreduction of U(VI) and Tc(VII) mixtures commonly found with NO3- co-contamination at radioactive waste sites...
  26. Gerard P, Gerczuk P, Idupuganti R, Patnana M. Massive gastrointestinal bleeding due to an aorto-enteric fistula seen by technetium-99m-labeled red blood cell scintigraphy. Clin Nucl Med. 2007;32:551-2 pubmed
  27. Knesaurek K, Machac J, Muzinic M, DaCosta M, Zhang Z, Heiba S. Quantitative comparison of yttrium-90 (90Y)-microspheres and technetium-99m (99mTc)-macroaggregated albumin SPECT images for planning 90Y therapy of liver cancer. Technol Cancer Res Treat. 2010;9:253-62 pubmed
    ..activity and the percent shunting to lungs must be determined, most commonly by gamma camera imaging of technetium-99m ((99m)Tc)-macroaggregated albumin (MAA)...
  28. Payne A, DiChristina T. A rapid mutant screening technique for detection of technetium [Tc(VII)] reduction-deficient mutants of Shewanella oneidensis MR-1. FEMS Microbiol Lett. 2006;259:282-7 pubmed
    ..strategies for reductive precipitation and immobilization of toxic metals such as the radionuclide technetium [Tc(VII)]...
  29. Alliot I, Alliot C, Vitorge P, Fattahi M. Speciation of technetium(IV) in bicarbonate media. Environ Sci Technol. 2009;43:9174-82 pubmed publisher
    The technetium isotope (99)Tc is a major fission product from nuclear reactors. Ultimately it is disposed of as radioactive waste since it has few applications outside of scientific research...
  30. Fonseca A, Frydman J, Rocha V, Bernardo Filho M. Acetylsalicylic acid decreases the labeling of blood constituents with technetium-99M. Acta Biol Hung. 2007;58:187-98 pubmed
    ..Drugs can modify the labeling of blood constituents with technetium-99m (99mTc)...
  31. Livens F, Jones M, Hynes A, Charnock J, Mosselmans J, Hennig C, et al. X-ray absorption spectroscopy studies of reactions of technetium, uranium and neptunium with mackinawite. J Environ Radioact. 2004;74:211-9 pubmed
    b>Technetium, uranium and neptunium may all occur in the environment in more than one oxidation state (IV or VII, IV or VI and IV or V respectively)...
  32. Quigley A, Gnanasegaran G, Buscombe J, Hilson A. Technetium-99m-labelled sulesomab (LeukoScan) in the evaluation of soft tissue infections. Med Princ Pract. 2008;17:447-52 pubmed publisher
    To perform a retrospective review of all patients receiving technetium-99m ((99m)Tc)-labelled sulesomab over a 4-year period to determine if soft tissue infections can be accurately identified.
  33. Bajelidze G, Belthur M, Littleton A, Dabney K, Miller F. Diagnostic evaluation using whole-body technetium bone scan in children with cerebral palsy and pain. J Pediatr Orthop. 2008;28:112-7 pubmed
    ..The purpose of this study is to report our experience using a 3-phase whole-body technetium bone scan as a screening tool in identifying the source of persistent pain in children with profound ..
  34. Barbash I, Chouraqui P, Baron J, Feinberg M, Etzion S, Tessone A, et al. Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution. Circulation. 2003;108:863-8 pubmed
    ..Systemic delivery of bone marrow-derived mesenchymal stem cells (BM-MSCs) is an attractive approach for myocardial repair. We aimed to test this strategy in a rat model after myocardial infarction (MI)...
  35. Laverman P, Behe M, Oyen W, Willems P, Corstens F, Behr T, et al. Two technetium-99m-labeled cholecystokinin-8 (CCK8) peptides for scintigraphic imaging of CCK receptors. Bioconjug Chem. 2004;15:561-8 pubmed
    ..Therefore, further studies are warranted to investigate the possible use of (99m)Tc-sCCK8 for scintigraphic imaging of CCK receptor-positive tumors in humans...
  36. Zheng J, Tan T. Antisense imaging of colon cancer-bearing nude mice with liposome-entrapped 99m-technetium-labeled antisense oligonucleotides of c-myc mRNA. World J Gastroenterol. 2004;10:2563-6 pubmed
    To investigate the feasibility for antisense imaging of the colon cancer with liposome-entrapped 99 m-technetium labeled antisense oligonucleotides as tracers.
  37. Vicente A, Almoguera M, Alonso J, Heffernan A, Gomez A, Contreras P, et al. Diagnosis of orthopedic infection in clinical practice using Tc-99m sulesomab (antigranulocyte monoclonal antibody fragment Fab'2). Clin Nucl Med. 2004;29:781-5 pubmed
    ..Infection was ruled out with negative cultures or 1-year patient follow up with negative C-reactive protein and normal erythrocyte sedimentation rate...
  38. Siaens R, Rennen H, Boerman O, Dierckx R, Slegers G. Synthesis and comparison of 99mTc-enrofloxacin and 99mTc-ciprofloxacin. J Nucl Med. 2004;45:2088-94 pubmed
    ..The rationale of this work was to determine possible differences in the use of 2 labeled quinolones--that is, (99m)Tc-ciprofloxacin and (99m)Tc-enrofloxacin--as tracers for infection and inflammation in animals...
  39. Okarvi S, Jammaz I. Preparation and in vitro and in vivo evaluation of technetium-99m-labeled folate and methotrexate conjugates as tumor imaging agents. Cancer Biother Radiopharm. 2006;21:49-60 pubmed
    ..We have prepared and evaluated technetium-99m (99mTc)- labeled FA and MTX analogs using MAG3 and MAG2 chelating agents in an attempt to develop folate-..
  40. Orlova A, Nilsson F, Wikman M, Widström C, Ståhl S, Carlsson J, et al. Comparative in vivo evaluation of technetium and iodine labels on an anti-HER2 affibody for single-photon imaging of HER2 expression in tumors. J Nucl Med. 2006;47:512-9 pubmed
    ..The goals of the present study were to prepare 99mTc-labeled His6-(ZHER2:4)2 and to evaluate its targeting properties compared with the targeting properties of 125I-4-iodobenzoate-His6-(ZHER2:4)2 [125I-His6-(ZHER2:4)2]...
  41. Gratz S, Behr T, Reize P, Pfestroff A, Kampen W, Hoffken H. (99m)Tc-Fab' fragments (sulesomab) for imaging septically loosened total knee arthroplasty. J Int Med Res. 2009;37:54-67 pubmed
    ..Quantitative evaluation of (99m)Tc-Fab' fragments is highly sensitive and specific for diagnostic imaging of infection in patients with septically-loosened TKA...
  42. Michalsen M, Peacock A, Spain A, Smithgal A, White D, Sanchez Rosario Y, et al. Changes in microbial community composition and geochemistry during uranium and technetium bioimmobilization. Appl Environ Microbiol. 2007;73:5885-96 pubmed
    ..0003) between microbial community compositions within stimulated and control sediments, with geochemical variables explaining 68% of the variance in community composition on the first two canonical axes...
  43. Zhang Y, Sun Y, Xu X, Zhang X, Zhu H, Huang L, et al. Synthesis, biodistribution, and microsingle photon emission computed tomography (SPECT) imaging study of technetium-99m labeled PEGylated dendrimer poly(amidoamine) (PAMAM)-folic acid conjugates. J Med Chem. 2010;53:3262-72 pubmed publisher
    ..These studies show that PEGylation of PAMAM dendrimer folic acid conjugate improves the tumor targeting. Folate-conjugated dendrimer maybe developed to be potential radiopharmaceuticals and targeted drug delivery systems...
  44. Zhuang Z, Kung M, Hou C, Ploessl K, Kung H. Biphenyls labeled with technetium 99m for imaging beta-amyloid plaques in the brain. Nucl Med Biol. 2005;32:171-84 pubmed
    ..The aim of this study was to develop potential technetium 99m (99mTc)-labeled diagnostic imaging agents specific for the detection of Abeta plaques...
  45. Soluri A, Scopinaro F, De Vincentis G, Varvarigou A, Scafè R, Massa R, et al. 99MTC [13LEU] bombesin and a new gamma camera, the imaging probe, are able to guide mammotome breast biopsy. Anticancer Res. 2003;23:2139-42 pubmed
    ..99mTc BN is a new radiotracer derived from the well-known peptide, that has already shown very high sensitivity in detecting breast cancer...
  46. Lear G, McBeth J, Boothman C, Gunning D, Ellis B, Lawson R, et al. Probing the biogeochemical behavior of technetium using a novel nuclear imaging approach. Environ Sci Technol. 2010;44:156-62 pubmed publisher
    Dynamic gamma-camera imaging of radiotracer technetium ((99m)Tc) was used to assess the impact of biostimulation of metal-reducing bacteria on technetium mobility at 10(-12) mol L(-1) concentrations in sediments...
  47. Tavare R, Torres Martin De Rosales R, Blower P, Mullen G. Efficient site-specific radiolabeling of a modified C2A domain of synaptotagmin I with [99mTc(CO)3]+: a new radiopharmaceutical for imaging cell death. Bioconjug Chem. 2009;20:2071-81 pubmed publisher
  48. Fujimoto K, Morita T. Aerobic removal of technetium by a marine Halomonas strain. Appl Environ Microbiol. 2006;72:7922-4 pubmed
    ..Tc-202 removed 55% of the total 99Tc in solutions at 15 degrees C by reducing Tc(VII) to Tc(V), but other Halomonas strains did not...
  49. Lorberboym M, Watemberg N, Nissenkorn A, Nir B, Lerman Sagie T. Technetium 99m ethylcysteinate dimer single-photon emission computed tomography (SPECT) during intellectual stress test in children and adolescents with pure versus comorbid attention-deficit hyperactivity disorder (ADHD). J Child Neurol. 2004;19:91-6 pubmed
    ..We postulate that these findings can have therapeutic implications and explain the decreased response to stimulants in this group of patients...
  50. Wirrwar A, Buchholz D, Gottschalk O, Viehöver S, Schramm N, Müller H. Dynamic observation of the three-dimensional distribution of labeled liposomes using the novel high-resolution single-photon emission computed tomography. Mol Imaging. 2008;7:234-8 pubmed
    ..This study shows that the HiSPECT technique is capable of dynamically visualizing the uptake behavior of radioactively labeled liposomes in vivo with high temporal and spatial resolution...
  51. Levashova Z, Backer M, Backer J, Blankenberg F. Direct site-specific labeling of the Cys-tag moiety in scVEGF with technetium 99m. Bioconjug Chem. 2008;19:1049-54 pubmed publisher
    ..The simple production of scVEGF for direct chelation of (99m)Tc makes it a promising molecular imaging agent for the oncology clinic...
  52. Aquino J, Pinheiro L, Vasques P, Rocha J, Cruz D, Beserra H, et al. Experimental canine model for sentinel lymph node biopsy in the vulva using technetium and patent blue dye. Acta Cir Bras. 2012;27:102-8 pubmed
    ..This paper aims to study and define the experimental model of sentinel lymph node biopsy of the vulva in bitches...
  53. Orlova A, Hofström C, Strand J, Varasteh Z, Sandström M, Andersson K, et al. [99mTc(CO)3]+-(HE)3-ZIGF1R:4551, a new Affibody conjugate for visualization of insulin-like growth factor-1 receptor expression in malignant tumours. Eur J Nucl Med Mol Imaging. 2013;40:439-49 pubmed publisher
    ..We hypothesized that inclusion of a HEHEHE tag instead of a His(6) tag in Z(IGF1R:4551) would permit its convenient purification using IMAC, enable labelling with [(99m)Tc(CO)(3)](+), and improve its biodistribution...