tellurium

Summary

Summary: An element that is a member of the chalcogen family. It has the atomic symbol Te, atomic number 52, and atomic weight 127.60. It has been used as a coloring agent and in the manufacture of electrical equipment. Exposure may cause nausea, vomiting, and CNS depression.

Top Publications

  1. Tian J, Liu R, Zhao Y, Peng Y, Hong X, Xu Q, et al. Synthesis of CdTe/CdS/ZnS quantum dots and their application in imaging of hepatocellular carcinoma cells and immunoassay for alpha fetoprotein. Nanotechnology. 2010;21:305101 pubmed publisher
  2. Zhang H, Sun P, Liu C, Gao H, Xu L, Fang J, et al. L-Cysteine capped CdTe-CdS core-shell quantum dots: preparation, characterization and immuno-labeling of HeLa cells. Luminescence. 2011;26:86-92 pubmed publisher
    ..It was indicated that this kind of QD would have application potential in bio-labeling and cell imaging...
  3. Ba L, Döring M, Jamier V, Jacob C. Tellurium: an element with great biological potency and potential. Org Biomol Chem. 2010;8:4203-16 pubmed publisher
    b>Tellurium has long appeared as a nearly 'forgotten' element in Biology, with most studies focusing on tellurite, tellurate and a handful of organic tellurides...
  4. Cunha R, Gouvea I, Juliano L. A glimpse on biological activities of tellurium compounds. An Acad Bras Cienc. 2009;81:393-407 pubmed
    b>Tellurium is a rare element which has been regarded as a toxic, non-essential trace element and its biological role is not clearly established to date...
  5. Khatchadourian A, Maysinger D. Lipid droplets: their role in nanoparticle-induced oxidative stress. Mol Pharm. 2009;6:1125-37 pubmed publisher
    ..Results from these studies suggest that oleic acid-induced LD in PC12 cells are dynamic and adaptive organelles, which provide energy to starving cells and facilitate their rescue under starvation and exposure to metallic nanoparticles...
  6. Valdivia González M, Pérez Donoso J, Vásquez C. Effect of tellurite-mediated oxidative stress on the Escherichia coli glycolytic pathway. Biometals. 2012;25:451-8 pubmed publisher
    ..coli shifts the carbon flux towards the pentose phosphate pathway thus facilitating the functioning of the Entner-Doudoroff pathway and/or the glycolytic productive phase...
  7. Lin Z, Lee C, Chang H, Chang H. Antibacterial activities of tellurium nanomaterials. Chem Asian J. 2012;7:930-4 pubmed publisher
    ..Compared to Ag nanoparticles that are commonly used as antibacterial reagents, Te NMs have higher antibacterial activity and lower toxicity. Thus, Te NMs hold great practical potential as a new and efficient antibacterial agent...
  8. Musalova M, Potapov V, Amosova S. Synthesis of novel E-2-chlorovinyltellurium compounds based on the stereospecific anti-addition of tellurium tetrachloride to acetylene. Molecules. 2012;17:5770-9 pubmed publisher
    The reaction of tellurium tetrachloride with acetylene proceeds in a stereospecific anti-addition manner to afford the novel products E-2-chlorovinyltellurium trichloride and E,E-bis(2-chlorovinyl)tellurium dichloride...
  9. Prigent Combaret C, Sanguin H, Champier L, Bertrand C, Monnez C, Colinon C, et al. The bacterial thiopurine methyltransferase tellurite resistance process is highly dependent upon aggregation properties and oxidative stress response. Environ Microbiol. 2012;14:2645-60 pubmed publisher
    ..High tellurite resistance required a synergistic expression of these functions and an efficient tellurium volatilization by the bTPMT.

More Information

Publications62

  1. Vij P, Hardej D. Evaluation of tellurium toxicity in transformed and non-transformed human colon cells. Environ Toxicol Pharmacol. 2012;34:768-82 pubmed publisher
    Diphenyl ditelluride (DPDT) and tellurium tetrachloride (TeCl(4)) were evaluated for toxicity in transformed (HT-29, Caco-2) and non-transformed colon cells (CCD-18Co)...
  2. Xu P, Li J, Shi L, Selke M, Chen B, Wang X. Synergetic effect of functional cadmium-tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition. Int J Nanomedicine. 2013;8:3729-36 pubmed publisher
    We prepared and studied novel fluorescent nanocomposites based on gambogic acid (GA) and cadmium-tellurium (CdTe) quantum dots (CdTe QDs) modified with cysteamine for purpose of cancer cell labeling and combined treatment...
  3. Tiekink E. Therapeutic potential of selenium and tellurium compounds: opportunities yet unrealised. Dalton Trans. 2012;41:6390-5 pubmed publisher
    ..being disparaged for their malodorous and toxic demeanour, compounds of selenium, a bio-essential element, and tellurium, offer possibilities as therapeutic agents...
  4. Molina Quiroz R, Muñoz Villagrán C, de la Torre E, Tantaleán J, Vásquez C, Pérez Donoso J. Enhancing the antibiotic antibacterial effect by sub lethal tellurite concentrations: tellurite and cefotaxime act synergistically in Escherichia coli. PLoS ONE. 2012;7:e35452 pubmed publisher
    ..Aiming to explore new alternatives to treat antibiotic-resistant bacteria and given that the tellurium oxyanion tellurite is highly toxic for most microorganisms, we evaluated the ability of sub lethal tellurite ..
  5. Reinoso C, Auger C, Appanna V, Vásquez C. Tellurite-exposed Escherichia coli exhibits increased intracellular ?-ketoglutarate. Biochem Biophys Res Commun. 2012;421:721-6 pubmed publisher
    The tellurium oxyanion tellurite is toxic to most organisms because of its ability to generate oxidative stress. However, the detailed mechanism(s) how this toxicant interferes with cellular processes have yet to be fully understood...
  6. Halperin Sheinfeld M, Gertler A, Okun E, Sredni B, Cohen H. The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes. Aging (Albany NY). 2012;4:436-47 pubmed
    ..Together, these findings demonstrate the therapeutic potential of AS101 for treating T2D, and for reversing impaired fat and glucose metabolism...
  7. Anantharaman V, Iyer L, Aravind L. Ter-dependent stress response systems: novel pathways related to metal sensing, production of a nucleoside-like metabolite, and DNA-processing. Mol Biosyst. 2012;8:3142-65 pubmed publisher
    ..In some eukaryotes, certain components of the ter system appear to be recruited to function in conjunction with the ubiquitin system and calcium-signaling pathways...
  8. Yu F, Li P, Wang B, Han K. Reversible near-infrared fluorescent probe introducing tellurium to mimetic glutathione peroxidase for monitoring the redox cycles between peroxynitrite and glutathione in vivo. J Am Chem Soc. 2013;135:7674-80 pubmed publisher
    ..The probe would provide a significant advance on the redox events involved in the cellular redox regulation...
  9. Cui S, Chahal R, Boussard Pledel C, Nazabal V, Doualan J, Troles J, et al. From selenium- to tellurium-based glass optical fibers for infrared spectroscopies. Molecules. 2013;18:5373-88 pubmed publisher
    Chalcogenide glasses are based on sulfur, selenium and tellurium elements, and have been studied for several decades regarding different applications...
  10. Bruneau A, Fortier M, Gagne F, Gagnon C, Turcotte P, Tayabali A, et al. Size distribution effects of cadmium tellurium quantum dots (CdS/CdTe) immunotoxicity on aquatic organisms. Environ Sci Process Impacts. 2013;15:596-607 pubmed
    ..8 nm), 30 kDa (4.6 nm), 10 kDa (3.2 nm) and 1 kDa (1.5 nm). The total concentrations of cadmium and tellurium were determined for the filtered material and for that retained on the filters (retentate)...
  11. Rojas D, Vásquez C. Sensitivity to potassium tellurite of Escherichia coli cells deficient in CSD, CsdB and IscS cysteine desulfurases. Res Microbiol. 2005;156:465-71 pubmed
    ..Complementation analysis could not be performed under anaerobic conditions because the three mutants did not show tellurite hypersensitivity. These results indicate that oxidative stress is involved in tellurite toxicity in E. coli...
  12. Gagne F, Auclair J, Turcotte P, Fournier M, Gagnon C, Sauve S, et al. Ecotoxicity of CdTe quantum dots to freshwater mussels: impacts on immune system, oxidative stress and genotoxicity. Aquat Toxicol. 2008;86:333-40 pubmed
    ..A multivariate analysis revealed that the various response patterns differed based on the concentration of CdTe, thus permitting the identification of biomarkers associated with the form (colloidal vs. molecular) of cadmium...
  13. Tremaroli V, Fedi S, Zannoni D. Evidence for a tellurite-dependent generation of reactive oxygen species and absence of a tellurite-mediated adaptive response to oxidative stress in cells of Pseudomonas pseudoalcaligenes KF707. Arch Microbiol. 2007;187:127-35 pubmed
    Tellurite (TeO3(2-)) is the most toxic and soluble oxyanion among tellurium (Te) compounds. The effects of the metalloid anion on the oxidative stress response of the obligate aerobe Pseudomonas pseudoalcaligenes KF707 were investigated...
  14. Byrne S, Le Bon B, Corr S, Stefanko M, O Connor C, Gun ko Y, et al. Synthesis, characterisation, and biological studies of CdTe quantum dot-naproxen conjugates. ChemMedChem. 2007;2:183-6 pubmed
  15. Xia Y, Song L, Zhu C. Turn-on and near-infrared fluorescent sensing for 2,4,6-trinitrotoluene based on hybrid (gold nanorod)-(quantum dots) assembly. Anal Chem. 2011;83:1401-7 pubmed publisher
    ..1 nM. Importantly, TNT can be well distinguished from its analogues due to their electron deficiency difference. The developed method is successfully applied to TNT sensing in real environmental samples...
  16. Dittmer D, Li Q, Avilov D. Synthesis of coumarins, 4-hydroxycoumarins, and 4-hydroxyquinolinones by tellurium-triggered cyclizations. J Org Chem. 2005;70:4682-6 pubmed
    ..Phenylketene formation competes with cyclization of the alpha-chlorophenylacetate ester of methyl salicylate as demonstrated by a trapping experiment with benzylamine. Elemental tellurium may be recovered and reused.
  17. Lithgow J, Hayhurst E, Cohen G, Aharonowitz Y, Foster S. Role of a cysteine synthase in Staphylococcus aureus. J Bacteriol. 2004;186:1579-90 pubmed
    ..aureus to recover from starvation in amino acid- or phosphate-limiting conditions, indicating a role for cysteine in the S. aureus stress response and survival mechanisms...
  18. Brodsky M, Yosef S, Galit R, Albeck M, Longo D, Albeck A, et al. The synthetic tellurium compound, AS101, is a novel inhibitor of IL-1beta converting enzyme. J Interferon Cytokine Res. 2007;27:453-62 pubmed
    ..Thus, their blockage by the nontoxic compound, AS101, currently used in clinical studies, may provide clinical advantage in the treatment of these diseases...
  19. Law W, Yong K, Roy I, Ding H, Hu R, Zhao W, et al. Aqueous-phase synthesis of highly luminescent CdTe/ZnTe core/shell quantum dots optimized for targeted bioimaging. Small. 2009;5:1302-10 pubmed publisher
    ..In addition, the QDs are used for small-animal imaging where the in vivo biocompatiblity of these QDs and their clearance following systemic injection is studied...
  20. Li S, Wang H, Qi Y, Tu J, Bai Y, Tian T, et al. Assessment of nanomaterial cytotoxicity with SOLiD sequencing-based microRNA expression profiling. Biomaterials. 2011;32:9021-30 pubmed publisher
  21. Sredni B, Gal R, Cohen I, Dazard J, Givol D, Gafter U, et al. Hair growth induction by the Tellurium immunomodulator AS101: association with delayed terminal differentiation of follicular keratinocytes and ras-dependent up-regulation of KGF expression. FASEB J. 2004;18:400-2 pubmed
    ..The results emphasize the unique mode of action of AS101 and highlight its potential clinical use for treating certain types of alopecia...
  22. Bailey R, Nie S. Alloyed semiconductor quantum dots: tuning the optical properties without changing the particle size. J Am Chem Soc. 2003;125:7100-6 pubmed
  23. Tremaroli V, Workentine M, Weljie A, Vogel H, Ceri H, Viti C, et al. Metabolomic investigation of the bacterial response to a metal challenge. Appl Environ Microbiol. 2009;75:719-28 pubmed publisher
    ..We conclude that hyperresistance to tellurite in P. pseudoalcaligenes KF707 is correlated with the induction of the oxidative stress response, resistance to membrane perturbation, and reconfiguration of cellular metabolism...
  24. Toews A, Roe E, Goodrum J, Bouldin T, Weaver J, Goines N, et al. Tellurium causes dose-dependent coordinate down-regulation of myelin gene expression. Brain Res Mol Brain Res. 1997;49:113-9 pubmed
    Exposure of developing rats to a diet containing elemental tellurium systemically inhibits cholesterol synthesis at the level of squalene epoxidase. At high tellurium exposure levels (> 0...
  25. Lovric J, Bazzi H, Cuie Y, Fortin G, Winnik F, Maysinger D. Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots. J Mol Med (Berl). 2005;83:377-85 pubmed
    ..These findings suggest that the size of QDs contributes to their subcellular distribution and that drugs can alter QD-induced cytotoxicity...
  26. Sheng J, Hassan A, Huang Z. New telluride-mediated elimination for novel synthesis of 2',3'-didehydro-2',3'-dideoxynucleosides. J Org Chem. 2008;73:3725-9 pubmed publisher
    ..Our novel strategy has great potential to simplify synthesis of these drugs and to further reduce cost of AIDS treatment and will also facilitate development of novel d4N and ddN analogues...
  27. Zawadzka A, Crawford R, Paszczynski A. Pyridine-2,6-bis(thiocarboxylic acid) produced by Pseudomonas stutzeri KC reduces and precipitates selenium and tellurium oxyanions. Appl Environ Microbiol. 2006;72:3119-29 pubmed
    ..of Pseudomonas stutzeri KC, pyridine-2,6-bis(thiocarboxylic acid) (pdtc), is shown to detoxify selenium and tellurium oxyanions in bacterial cultures. A mechanism for pdtc's detoxification of tellurite and selenite is proposed...
  28. Zhang Y, Chen W, Zhang J, Liu J, Chen G, Pope C. In vitro and in vivo toxicity of CdTe nanoparticles. J Nanosci Nanotechnol. 2007;7:497-503 pubmed
  29. Conroy J, Byrne S, Gun ko Y, Rakovich Y, Donegan J, Davies A, et al. CdTe nanoparticles display tropism to core histones and histone-rich cell organelles. Small. 2008;4:2006-15 pubmed publisher
    ..These findings strongly suggest that charge-mediated QD/histone interactions could provide the basis for QD nuclear localization downstream of intracellular transport mechanisms...
  30. Borsetti F, Tremaroli V, Michelacci F, Borghese R, Winterstein C, Daldal F, et al. Tellurite effects on Rhodobacter capsulatus cell viability and superoxide dismutase activity under oxidative stress conditions. Res Microbiol. 2005;156:807-13 pubmed
    ..capsulatus against periplasmic oxidative stress; and finally, (4) SenC protein is not involved in TeR, possibly because tellurite does not generate O-2 at the periplasmic space level...
  31. Abbene L, Gerardi G, Principato F, Del Sordo S, Ienzi R, Raso G. High-rate x-ray spectroscopy in mammography with a CdTe detector: a digital pulse processing approach. Med Phys. 2010;37:6147-56 pubmed
    ..In this work we present a detection system, based on a CdTe detector and an innovative digital pulse processing (DPP) system, for high-rate x-ray spectroscopy in mammography...
  32. Baesman S, Bullen T, Dewald J, Zhang D, Curran S, Islam F, et al. Formation of tellurium nanocrystals during anaerobic growth of bacteria that use Te oxyanions as respiratory electron acceptors. Appl Environ Microbiol. 2007;73:2135-43 pubmed
    ..of selenium also achieve growth by reduction of either tellurate [Te(VI)] or tellurite [Te(IV)] to elemental tellurium [Te(0)]...
  33. Cho S, Maysinger D, Jain M, Röder B, Hackbarth S, Winnik F. Long-term exposure to CdTe quantum dots causes functional impairments in live cells. Langmuir. 2007;23:1974-80 pubmed
    ..In summary, CdTe QDs induce cell death via mechanisms involving both Cd2+ and ROS accompanied by lysosomal enlargement and intracellular redistribution...
  34. Ma J, Chen J, Zhang Y, Wang P, Guo J, Yang W, et al. Photochemical instability of thiol-capped CdTe quantum dots in aqueous solution and living cells: process and mechanism. J Phys Chem B. 2007;111:12012-6 pubmed
    ..By comparing the photostability of QDs in C2C12 cells with and without NaN3 treatment, the photooxidation effect of 1O2 on photobleaching of cellular QDs was confirmed...
  35. Fuentes D, Fuentes E, Castro M, Perez J, Araya M, Chasteen T, et al. Cysteine metabolism-related genes and bacterial resistance to potassium tellurite. J Bacteriol. 2007;189:8953-60 pubmed
    ..Results showed that cell tolerance to tellurite correlates with the expression level of the cysteine metabolic genes and that these genes are up-regulated when tellurite is present in the growth medium...
  36. Chasteen T, Bentley R. Biomethylation of selenium and tellurium: microorganisms and plants. Chem Rev. 2003;103:1-25 pubmed
  37. Schneider R, Wolpert C, Guilloteau H, Balan L, Lambert J, Merlin C. The exposure of bacteria to CdTe-core quantum dots: the importance of surface chemistry on cytotoxicity. Nanotechnology. 2009;20:225101 pubmed publisher
    ..Our study suggests that QD cytotoxicity is rather due to the formation of TeO2 and probably the existence of CdO formed by surface oxidation. In this respect, QDs possessing a CdO shell appeared very toxic...
  38. Kuo C, Jiang S. Determination of selenium and tellurium compounds in biological samples by ion chromatography dynamic reaction cell inductively coupled plasma mass spectrometry. J Chromatogr A. 2008;1181:60-6 pubmed publisher
    ..coupled plasma mass spectrometric (IC-ICP-MS) method for the speciation of selenium and tellurium compounds namely selenite [Se(IV)], selenate [Se(VI)], Se-methylselenocysteine (MeSeCys), selenomethione (SeMet),..
  39. Tantaleán J, Araya M, Saavedra C, Fuentes D, Perez J, Calderón I, et al. The Geobacillus stearothermophilus V iscS gene, encoding cysteine desulfurase, confers resistance to potassium tellurite in Escherichia coli K-12. J Bacteriol. 2003;185:5831-7 pubmed
    ..These and other results support the hypothesis that the reduction of tellurite generates superoxide anions and that the primary targets of superoxide damage in E. coli are enzymes with iron-sulfur clusters...
  40. Gerhards C, Schulz Drost C, Sgobba V, Guldi D. Conjugating luminescent CdTe quantum dots with biomolecules. J Phys Chem B. 2008;112:14482-91 pubmed publisher
    ..Notably, these interactions depend on the size of the QDs. Repulsive forces, on the other hand, are operative between the positively capped QDs and cyt c, hampering any bioconjugation...
  41. Bang J, Kamat P. Quantum dot sensitized solar cells. A tale of two semiconductor nanocrystals: CdSe and CdTe. ACS Nano. 2009;3:1467-76 pubmed publisher
    ..The anodic corrosion and exchange of Te with S dominate the charge transfer at the CdTe interface. Factors that dictate the efficiency and photostability of CdSe and CdTe quantum dots are discussed...
  42. Perez J, Calderón I, Arenas F, Fuentes D, Pradenas G, Fuentes E, et al. Bacterial toxicity of potassium tellurite: unveiling an ancient enigma. PLoS ONE. 2007;2:e211 pubmed
  43. Borsetti F, Francia F, Turner R, Zannoni D. The thiol:disulfide oxidoreductase DsbB mediates the oxidizing effects of the toxic metalloid tellurite (TeO32-) on the plasma membrane redox system of the facultative phototroph Rhodobacter capsulatus. J Bacteriol. 2007;189:851-9 pubmed
  44. Moroder L. Isosteric replacement of sulfur with other chalcogens in peptides and proteins. J Pept Sci. 2005;11:187-214 pubmed
    ..and proteins, the methionine and the serine/cysteine series, and discusses the synthesis of the related selenium/tellurium analogues as well as their use in peptide synthesis and protein expression...
  45. Bielaszewska M, Tarr P, Karch H, Zhang W, Mathys W. Phenotypic and molecular analysis of tellurite resistance among enterohemorrhagic Escherichia coli O157:H7 and sorbitol-fermenting O157:NM clinical isolates. J Clin Microbiol. 2005;43:452-4 pubmed
    ..5%) of 86 sorbitol-fermenting (SF) EHEC O157:NM strains had Te MICs of </=4 microg/ml, did not grow on Te-containing media, and lacked ter genes. Optimal detection of SF EHEC O157:NM strains requires Te-independent strategies...
  46. Goodrum J. Role of organotellurium species in tellurium neuropathy. Neurochem Res. 1998;23:1313-9 pubmed
    Exposure of weanling rats to a diet containing 1% elemental tellurium causes segmental demyelination of peripheral nerve, and an inhibition of squalene epoxidase...
  47. Park S, Chibli H, Wong J, Nadeau J. Antimicrobial activity and cellular toxicity of nanoparticle-polymyxin B conjugates. Nanotechnology. 2011;22:185101 pubmed publisher
    ..These results show that it is possible to create antimicrobial agents using concentrations of CdTe quantum dots that do not harm mammalian cells...
  48. Chasteen T, Fuentes D, Tantaleán J, Vásquez C. Tellurite: history, oxidative stress, and molecular mechanisms of resistance. FEMS Microbiol Rev. 2009;33:820-32 pubmed publisher
    The perceived importance of tellurium (Te) in biological systems has lagged behind selenium (Se), its lighter sister in the Group 16 chalcogens, because of tellurium's lower crustal abundance, lower oxyanion solubility and biospheric ..
  49. Castro M, Molina R, Díaz W, Pradenas G, Vásquez C. Expression of Aeromonas caviae ST pyruvate dehydrogenase complex components mediate tellurite resistance in Escherichia coli. Biochem Biophys Res Commun. 2009;380:148-52 pubmed publisher
    ..environmental isolate Aeromonas caviae ST is involved in the reduction of tellurite to elemental tellurium. In this work, we show that expression of A...
  50. Castro M, Molina R, Díaz W, Pichuantes S, Vásquez C. The dihydrolipoamide dehydrogenase of Aeromonas caviae ST exhibits NADH-dependent tellurite reductase activity. Biochem Biophys Res Commun. 2008;375:91-4 pubmed publisher
    ..coli, Zymomonas mobilis, Streptococcus pneumoniae, and Geobacillus stearothermophilus also showed NADH-dependent tellurite reductase in vitro suggesting that this enzymatic activity is widely distributed among microorganisms...
  51. Cunha R, Urano M, Chagas J, Almeida P, Bincoletto C, Tersariol I, et al. Tellurium-based cysteine protease inhibitors: evaluation of novel organotellurium(IV) compounds as inhibitors of human cathepsin B. Bioorg Med Chem Lett. 2005;15:755-60 pubmed
    ..All Te(IV) compounds tested exhibited high specific second-order constant for cathepsin B inactivation. Tellurium(IV) compound 6 was the best inhibitor of the series, showing a second-order constant of 36,000 M(-1)s(-1)...
  52. Taylor D, Rooker M, Keelan M, Ng L, Martin I, Perna N, et al. Genomic variability of O islands encoding tellurite resistance in enterohemorrhagic Escherichia coli O157:H7 isolates. J Bacteriol. 2002;184:4690-8 pubmed
    ..coli clinical isolate, suggests that the pathogenicity island was acquired from a plasmid. This work demonstrates diversity among E. coli O157:H7 isolates, at least as far as the presence of Te(r) genes is concerned...
  53. Sredni B, Geffen Aricha R, Duan W, Albeck M, Shalit F, Lander H, et al. Multifunctional tellurium molecule protects and restores dopaminergic neurons in Parkinson's disease models. FASEB J. 2007;21:1870-83 pubmed
    ..We report that the tellurium immunomodulating compound ammonium trichloro(dioxoethylene-O,O'-)tellurate (AS101) protects dopaminergic neurons ..