thallium

Summary

Summary: A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.

Top Publications

  1. Cáceres C, Wright G, Gouyette C, Parkinson G, Subirana J. A thymine tetrad in d(TGGGGT) quadruplexes stabilized with Tl+/Na+ ions. Nucleic Acids Res. 2004;32:1097-102 pubmed
    ..We show that by using MAD methods, Tl+ can be unambiguously located and distinguished from Na+. We can thus determine the preference for either ion in each ionic site of the structure under the conditions used by us...
  2. Pelclova D, Urban P, Ridzon P, Senholdová Z, Lukas E, Diblík P, et al. Two-year follow-up of two patients after severe thallium intoxication. Hum Exp Toxicol. 2009;28:263-72 pubmed publisher
    Information on the prognosis and electrophysiological follow-up of severe thallium poisoning is limited...
  3. Li S, Xiao T, Zheng B. Medical geology of arsenic, selenium and thallium in China. Sci Total Environ. 2012;421-422:31-40 pubmed publisher
    Arsenic (As), selenium (Se) and thallium (Tl) are three trace metals (metalloids) of high concern in China because deficiency or excess expose can cause a range of endemic diseases, such as endemic arsenism, selenosis, Keshan disease (KD),..
  4. Verstraeten S. Relationship between thallium(I)-mediated plasma membrane fluidification and cell oxidants production in Jurkat T cells. Toxicology. 2006;222:95-102 pubmed
    ..These effects could underlie the pathology associated with Tl(+) toxicity...
  5. Wierzbicka M, Szarek Łukaszewska G, Grodzinska K. Highly toxic thallium in plants from the vicinity of Olkusz (Poland). Ecotoxicol Environ Saf. 2004;59:84-8 pubmed
    b>Thallium is a highly toxic metal that plays no role in the metabolism of plants or animals...
  6. Soma T, Takaki A, Teraoka S, Ishikawa Y, Murase K, Koizumi K. Behaviors of cost functions in image registration between 201Tl brain tumor single-photon emission computed tomography and magnetic resonance images. Ann Nucl Med. 2008;22:825-32 pubmed publisher
    We studied the behaviors of cost functions in the registration of thallium-201 (201Tl) brain tumor single-photon emission computed tomography (SPECT) and magnetic resonance (MR) images, as the similarity index of image positioning.
  7. Matsuki T, Tamaki N, Nakata T, Doi A, Takahashi H, Iwata M, et al. Prognostic value of fatty acid imaging in patients with angina pectoris without prior myocardial infarction: comparison with stress thallium imaging. Eur J Nucl Med Mol Imaging. 2004;31:1585-91 pubmed
    ..In conclusion, normal BMIPP imaging is an excellent prognostic sign, independently of stress myocardial perfusion imaging, in patients with angina pectoris without prior MI...
  8. Tao Z, Gameiro A, Grewer C. Thallium ions can replace both sodium and potassium ions in the glutamate transporter excitatory amino acid carrier 1. Biochemistry. 2008;47:12923-30 pubmed publisher
    ..However, in contrast to GltPh, which does not bind K(+), Tl(+) is more efficient in mimicking K(+) than Na(+) when interacting with the mammalian protein...
  9. Aktas A, Yalcin H, Koyuncu A, Aydinalp A, Muderrisoglu H. The influence of post-exercise cardiac changes on thallium-gated myocardial perfusion scintigraphy findings in normal subjects. Nucl Med Commun. 2005;26:109-14 pubmed
    ..Systolic cardiac parameters on gated stress and rest images were evaluated in healthy young and elderly subjects...

More Information

Publications62

  1. Schmalhofer W, Swensen A, Thomas B, Felix J, Haedo R, Solly K, et al. A pharmacologically validated, high-capacity, functional thallium flux assay for the human Ether-à-go-go related gene potassium channel. Assay Drug Dev Technol. 2010;8:714-26 pubmed publisher
    ..In the present study, we describe a high-capacity, 384- and 1,536-well plate, functional thallium flux assay for the hERG channel that fulfills these criteria...
  2. Casiot C, Egal M, Bruneel O, Verma N, Parmentier M, Elbaz Poulichet F. Predominance of aqueous Tl(I) species in the river system downstream from the abandoned Carnoulès mine (Southern France). Environ Sci Technol. 2011;45:2056-64 pubmed publisher
    b>Thallium concentration reached up to 534 ?g L(-1) in the Reigous acid mine drainage downstream from the abandoned Pb-Zn Carnoulès mine (Southern France). It decreased to 5.44 ?g L(-1) in the Amous River into which the Reigous creek flows...
  3. Madejón P, Murillo J, Marañón T, Valdes B, Rossini Oliva S. Thallium accumulation in floral structures of Hirschfeldia incana (L.) Lagrèze-Fossat (Brassicaceae). Bull Environ Contam Toxicol. 2005;74:1058-64 pubmed
  4. Lukaszewski Z, Karbowska B, Zembrzuski W, Siepak M. Thallium in fractions of sediments formed during the 2004 tsunami in Thailand. Ecotoxicol Environ Saf. 2012;80:184-9 pubmed publisher
    b>Thallium is a highly toxic element. Its concentration in sediment fractions from the 2004 tsunami in Thailand was investigated. A modified BCR procedure was used for sequential extraction...
  5. Jacobson A, McBride M, Baveye P, Steenhuis T. Environmental factors determining the trace-level sorption of silver and thallium to soils. Sci Total Environ. 2005;345:191-205 pubmed
    Silver (Ag) and thallium (Tl) are nonessential elements that can be highly toxic to a number of biota even when present in the environment at trace levels...
  6. Dadfarnia S, Assadollahi T, Haji Shabani A. Speciation and determination of thallium by on-line microcolumn separation/preconcentration by flow injection-flame atomic absorption spectrometry using immobilized oxine as sorbent. J Hazard Mater. 2007;148:446-52 pubmed
    ..a microcolumn of immobilized oxine on surfactant-coated alumina had been devised for performing rapid thallium enrichment/matrix removal in flame atomic absorption spectrometry (FAA)...
  7. Tsai Y, Huang C, Kuo H, Wang H, Shen W, Shih T, et al. Central nervous system effects in acute thallium poisoning. Neurotoxicology. 2006;27:291-5 pubmed
    ..neuropsychological studies and brain magnetic resonance image (MRI) findings of two patients with acute thallium intoxication...
  8. Comte F, Bauchet L, Rigau V, Hauet J, Fabbro M, Coubes P, et al. Correlation of preoperative thallium SPECT with histological grading and overall survival in adult gliomas. Nucl Med Commun. 2006;27:137-42 pubmed
    ..It has been proposed that thallium single photon emission computed tomography (SPECT), in a relative short series, will aid this prediction.
  9. Hasbek Z, Turgut B, Erselcan T, Yalta K, Tandogan I, Ozer G, et al. Evaluation of myocardial viability with thallium-201 infusion MPSPECT after oral glucose application in patients with chronic coronary artery disease. Nucl Med Commun. 2009;30:779-88 pubmed publisher
    ..in nondiabetic patients with chronic coronary artery disease (CCAD) or past myocardial infarction (MI), using thallium-201 infusion myocardial perfusion single-photon emission computed tomography (MPSPECT) imaging after oral glucose ..
  10. Wanger T, Scheich H, Ohl F, Goldschmidt J. The use of thallium diethyldithiocarbamate for mapping CNS potassium metabolism and neuronal activity: Tl+ -redistribution, Tl+ -kinetics and Tl+ -equilibrium distribution. J Neurochem. 2012;122:106-14 pubmed publisher
    The potassium (K(+)) analogue thallium (Tl(+)) can be used as a tracer for mapping neuronal activity...
  11. Döbert N, Britten M, Assmus B, Berner U, Menzel C, Lehmann R, et al. Transplantation of progenitor cells after reperfused acute myocardial infarction: evaluation of perfusion and myocardial viability with FDG-PET and thallium SPECT. Eur J Nucl Med Mol Imaging. 2004;31:1146-51 pubmed
    ..These preliminary results show that coronary stenting and transplantation of progenitor cells result in a significant increase in myocardial viability and perfusion. Therapeutic effects can be reliably measured by PET and SPECT...
  12. Pacheco P, Gil R, Smichowski P, Polla G, Martinez L. L-tyrosine immobilized on multiwalled carbon nanotubes: a new substrate for thallium separation and speciation using stabilized temperature platform furnace-electrothermal atomic absorption spectrometry. Anal Chim Acta. 2009;656:36-41 pubmed publisher
    An approach for the separation and determination of inorganic thallium species is described. A new sorbent, L-tyrosine-carbon nanotubes (L-tyr-CNTs), was used and applied to the analysis of tap water samples. At pH 5...
  13. Bridal T, Margulis M, Wang X, Donio M, Sorota S. Comparison of human Ether-à-go-go related gene screening assays based on IonWorks Quattro and thallium flux. Assay Drug Dev Technol. 2010;8:755-65 pubmed publisher
    ..multiwell hERG assays: a fluorescence-based fluorometric imaging plate reader (FLIPR(®)) screen measuring thallium (Tl(+)) influx through hERG channels and an automated patch clamp assay using an IonWorks Quattro(®)...
  14. Li Q, Rottländer M, Xu M, Christoffersen C, Frederiksen K, Wang M, et al. Identification of novel KCNQ4 openers by a high-throughput fluorescence-based thallium flux assay. Anal Biochem. 2011;418:66-72 pubmed publisher
    To develop a real-time thallium flux assay for high-throughput screening (HTS) of human KCNQ4 (Kv7...
  15. Zhao G, Ding M, Zhang B, Lv W, Yin H, Zhang L, et al. Clinical manifestations and management of acute thallium poisoning. Eur Neurol. 2008;60:292-7 pubmed publisher
    Clinical information regarding 3 patients diagnosed with acute thallium poisoning was collected and retrospectively analyzed. All 3 patients presented with severe burning pain in the lower limbs and the abdomen...
  16. Madejón P, Murillo J, Marañón T, Lepp N. Factors affecting accumulation of thallium and other trace elements in two wild Brassicaceae spontaneously growing on soils contaminated by tailings dam waste. Chemosphere. 2007;67:20-8 pubmed
    b>Thallium is a scarce, highly toxic element. There are several investigations that report Tl accumulation in plants of the family Brassicaceae...
  17. Lu C, Huang C, Chang Y, Tsai Y, Kuo H, Chuang Y, et al. Short-term thallium intoxication: dermatological findings correlated with thallium concentration. Arch Dermatol. 2007;143:93-8 pubmed
    The dermatological features and skin biopsy findings of short-term thallium intoxication have been described...
  18. Fernandez E, Laguna A, López de Luzuriaga J, Monge M, Montiel M, Olmos M. Photophysical studies and excited-state structure of a blue phosphorescent gold-thallium complex. Inorg Chem. 2007;46:2953-5 pubmed
    ..Density functional theory calculations show a distortion of the aurate-thallium T shape in the lowest triplet excited state, leading to a triplet metal-to-metal charge-transfer state.
  19. Shiga H, Taki J, Yamada M, Washiyama K, Amano R, Matsuura Y, et al. Evaluation of the olfactory nerve transport function by SPECT-MRI fusion image with nasal thallium-201 administration. Mol Imaging Biol. 2011;13:1262-6 pubmed publisher
    The aim of this study was to visualize the human olfactory transport pathway to the brain by performing imaging after nasal thallium-201 ((201)Tl) administration.
  20. Pappas R, Polzin G, Zhang L, Watson C, Paschal D, Ashley D. Cadmium, lead, and thallium in mainstream tobacco smoke particulate. Food Chem Toxicol. 2006;44:714-23 pubmed
    The deliveries of cadmium, thallium, and lead in mainstream smoke particulate from cigarettes with different smoke delivery designs were determined by inductively coupled plasma-mass spectrometry in order to investigate their impact on ..
  21. Teichman S, Qu S, Kanner B. The equivalent of a thallium binding residue from an archeal homolog controls cation interactions in brain glutamate transporters. Proc Natl Acad Sci U S A. 2009;106:14297-302 pubmed publisher
    ..Thus the conserved aspartate is required for transporter-cation interactions in each of the two separate translocation steps and likely participates in an overlapping sodium and potassium binding site...
  22. Sangvanich T, Sukwarotwat V, Wiacek R, Grudzien R, Fryxell G, Addleman R, et al. Selective capture of cesium and thallium from natural waters and simulated wastes with copper ferrocyanide functionalized mesoporous silica. J Hazard Mater. 2010;182:225-31 pubmed publisher
    ..been evaluated against iron(III) hexacyanoferrate(II) (insoluble Prussian Blue) for removing cesium (Cs(+)) and thallium (Tl(+)) from natural waters and simulated acidic and alkaline wastes. From pH 0.1-7...
  23. Sugawara Y, Kikuchi T, Kajihara M, Semba T, Ochi T, Fujii T, et al. Thallium-201 scintigraphy in bone and soft-tissue tumors: a comparison of dynamic, early and delayed scans. Ann Nucl Med. 2005;19:461-8 pubmed
    It has been reported that delayed scan of thallium-201 (201Tl) scintigraphy is useful for differentiating malignant tumors from benign lesions and for evaluating treatment response...
  24. Mochizuki M, Mori M, Akinaga M, Yugami K, Oya C, Hondo R, et al. Thallium contamination in wild ducks in Japan. J Wildl Dis. 2005;41:664-8 pubmed
    Although thallium (Tl) is toxic to both humans and animals, there is little information on contamination in wildlife. In this study, Tl contents in wild ducks in Japan were determined. Contents of Tl in kidney and liver ranged from 0...
  25. Wu W, Sharma S, Choudhary G, Coulter L, Coccio E, Eaton C. Flow-mediated vasodilation predicts the presence and extent of coronary artery disease assessed by stress thallium imaging. J Nucl Cardiol. 2005;12:538-44 pubmed
    ..Stress single photon emission computed tomography (SPECT) imaging is commonly used to study patients with CAD. We sought to study the relationship between endothelial dysfunction by FMD and stress thallium SPECT to detect CAD.
  26. Sato T, Indo H, Kawabata Y, Kobayashi T, Suenaga S, Iwashita Y, et al. Thallium-201 chloride (Tl-201) accumulation and Na+/K+-ATPase expression in tumours of the head and neck. Dentomaxillofac Radiol. 2005;34:212-7 pubmed
    The purpose of this report was to evaluate the relationship between the tumour retention index of thallium-201 chloride (Tl-201) scintigraphy and the Na+/K+-ATPase expression in tumours of the head and neck.
  27. Moulaei T, Maehigashi T, Lountos G, Komeda S, Watkins D, Stone M, et al. Structure of B-DNA with cations tethered in the major groove. Biochemistry. 2005;44:7458-68 pubmed
    ..The structure was determined from crystals soaked with thallium(I), which has been broadly used as a mimic of K(+) in X-ray diffraction experiments aimed at determining ..
  28. Peter A, Viraraghavan T. Thallium: a review of public health and environmental concerns. Environ Int. 2005;31:493-501 pubmed
    b>Thallium (Tl) is a rare but widely dispersed element. All forms of thallium are soluble enough to be toxic to living organisms...
  29. Xiao T, Guha J, Boyle D, Liu C, Chen J. Environmental concerns related to high thallium levels in soils and thallium uptake by plants in southwest Guizhou, China. Sci Total Environ. 2004;318:223-44 pubmed
    b>Thallium (Tl) contamination in soils poses a significant threat to human health due to the high toxicity of Tl and its ready assimilation by crops...
  30. Weaver C, Harden D, Dworetzky S, Robertson B, Knox R. A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells. J Biomol Screen. 2004;9:671-7 pubmed
    ..To address these issues, the authors have developed a fluorescence-based thallium flux assay...
  31. Scheckel K, Lombi E, Rock S, McLaughlin M. In vivo synchrotron study of thallium speciation and compartmentation in Iberis intermedia. Environ Sci Technol. 2004;38:5095-100 pubmed
    b>Thallium (TI) is a metal of great toxicological concern and its prevalence in the natural environment has steadily increased as a result of manufacturing and combustion practices...
  32. Goldschmidt J, Zuschratter W, Scheich H. High-resolution mapping of neuronal activity by thallium autometallography. Neuroimage. 2004;23:638-47 pubmed
    ..We have injected Mongolian gerbils with the K(+) analogue thallium (Tl(+)), stimulated the animals with pure tones of different frequencies and analyzed, by an autometallographic ..
  33. Gomez Rio M, Martínez Del Valle Torres D, Rodríguez Fernández A, Llamas Elvira J, Lozano S, Font C, et al. (201)Tl-SPECT in low-grade gliomas: diagnostic accuracy in differential diagnosis between tumour recurrence and radionecrosis. Eur J Nucl Med Mol Imaging. 2004;31:1237-43 pubmed
  34. Serizawa T, Saeki N, Higuchi Y, Ono J, Matsuda S, Sato M, et al. Diagnostic value of thallium-201 chloride single-photon emission computerized tomography in differentiating tumor recurrence from radiation injury after gamma knife surgery for metastatic brain tumors. J Neurosurg. 2005;102 Suppl:266-71 pubmed
    ..The authors assessed the diagnostic value of 201Tl Cl single-photon emission computerized tomography (SPECT), performed after gamma knife surgery (GKS) for metastatic brain tumors in differentiating tumor recurrence from radiation injury...
  35. Kinuya K, Ohashi M, Itoh S, Sakai S, Yamamoto K, Kakuda K, et al. Thallium-201 brain SPECT to diagnose aggressiveness of meningiomas. Ann Nucl Med. 2003;17:463-7 pubmed
    ..These results indicate that high pre-operative ER and LR values in patients with meningioma are indicators of the aggressiveness of lesions, i.e., malignant meningioma, recurrence or skull invasion...
  36. Lis J, Pasieczna A, Karbowska B, Zembrzuski W, Lukaszewski Z. Thallium in soils and stream sediments of a Zn-Pb mining and smelting area. Environ Sci Technol. 2003;37:4569-72 pubmed
    b>Thallium was determined in 120 samples of soil and 30 samples of stream sediments from the southeastern part of the Silesian-Cracowian zinc-lead ore deposits. Soil samples were taken from topsoils (0.0-0.2 m) and bottom soils (0.8 and 1...
  37. Zhang D, Gopalakrishnan S, Freiberg G, Surowy C. A thallium transport FLIPR-based assay for the identification of KCC2-positive modulators. J Biomol Screen. 2010;15:177-84 pubmed publisher
    ..Here the authors report the development of a fluorescence-based thallium (Tl(+)) transport assay using a Fluorometric Imaging Plate Reader (FLIPR), in which KCC2 activity is assessed by ..
  38. Volk M, Hamer O, Feuerbach S, Strotzer M. Dose reduction in skeletal and chest radiography using a large-area flat-panel detector based on amorphous silicon and thallium-doped cesium iodide: technical background, basic image quality parameters, and review of the literature. Eur Radiol. 2004;14:827-34 pubmed
    ..The large-area flat-panel detector based on amorphous silicon and thallium-doped cesium iodide provides a significant reduction of radiation dose in skeletal and chest radiography compared ..
  39. Tie J, Gunawardana D, Rosenthal M. Differentiation of tumor recurrence from radiation necrosis in high-grade gliomas using 201Tl-SPECT. J Clin Neurosci. 2008;15:1327-34 pubmed publisher
    ..b>Thallium-201 single-photon emission computed tomography ((201)Tl-SPECT) might be useful in distinguishing between these ..
  40. Pappas R, Polzin G, Watson C, Ashley D. Cadmium, lead, and thallium in smoke particulate from counterfeit cigarettes compared to authentic US brands. Food Chem Toxicol. 2007;45:202-9 pubmed
    ..We compared mainstream smoke cadmium, thallium, and lead deliveries from counterfeit and authentic brands...
  41. Gill M, Strobel S, Loria J. Crystallization and characterization of the thallium form of the Oxytricha nova G-quadruplex. Nucleic Acids Res. 2006;34:4506-14 pubmed
    ..The assignment of these resonances provides evidence for the occurrence of conformational dynamics in the thymine loop region that is in slow exchange on the 205Tl timescale...
  42. Gill M, Strobel S, Loria J. 205Tl NMR methods for the characterization of monovalent cation binding to nucleic acids. J Am Chem Soc. 2005;127:16723-32 pubmed
    ..This requirement can be satisfied by thallium (Tl+), a potassium (K+) surrogate...
  43. Augustynowicz J, Tokarz K, Baran A, Płachno B. Phytoremediation of water polluted by thallium, cadmium, zinc, and lead with the use of macrophyte Callitriche cophocarpa. Arch Environ Contam Toxicol. 2014;66:572-81 pubmed publisher
    ..work was to study the phytoremediation capacity of Callitriche cophocarpa concerning water contaminated with thallium (Tl), cadmium (Cd), zinc (Zn), and lead (Pb) derived from the natural environment...
  44. Cvjetko P, Cvjetko I, Pavlica M. Thallium toxicity in humans. Arh Hig Rada Toksikol. 2010;61:111-9 pubmed publisher
    b>Thallium is a naturally occurring trace element, widely distributed in the earth's crust, but at very low concentrations. It does not have a known biological use and does not appear to be an essential element for life...
  45. Yang Y, Faustino P, Progar J, Brownell C, Sadrieh N, May J, et al. Quantitative determination of thallium binding to ferric hexacyanoferrate: Prussian blue. Int J Pharm. 2008;353:187-94 pubmed publisher
    ..pharmaceutical ingredient (API) of Radiogardase which is the first approved drug product (DP) for treatment of thallium and radiocesium poisoning...
  46. Piskorowski R, Aldrich R. Relationship between pore occupancy and gating in BK potassium channels. J Gen Physiol. 2006;127:557-76 pubmed
    ..with respect to potassium for all permeant ions, BK channels required stronger depolarization to open only when thallium was the permeant ion. Thallium also slowed the activation and deactivation kinetics...
  47. Das A, Chakraborty R, Cervera M, de la Guardia M. Determination of thallium in biological samples. Anal Bioanal Chem. 2006;385:665-70 pubmed
    Determination of thallium has become a major interest because of its high toxicity, especially as the monovalent cation. Thallium poisoning in the human body must be checked quickly by analysis of biological samples...
  48. Kuo H, Huang C, Tsai Y, Chu C, Hsieh S, Chu N. Acute painful neuropathy in thallium poisoning. Neurology. 2005;65:302-4 pubmed
    Dysesthesia, allodynia, distal muscle weakness, and sensory impairment were noted in two patients with acute thallium intoxication. Two months later, nerve conduction studies showed an axonal degeneration...
  49. Jakubowska M, Pasieczna A, Zembrzuski W, Swit Z, Lukaszewski Z. Thallium in fractions of soil formed on floodplain terraces. Chemosphere. 2007;66:611-8 pubmed
    ..formed on the floodplain terrace of a rivulet flowing through the zinc-lead ore exploration area polluted with thallium and one soil from a floodplain terrace of the reference area were investigated in terms of thallium distribution ..
  50. Semba T, Sugawara Y, Ochi T, Fujii T, Mochizuki T, Ohnishi T. Thallium-201 SPECT in prognostic assessment of malignant gliomas treated with postoperative radiotherapy. Ann Nucl Med. 2006;20:287-94 pubmed
    This study was designed to investigate the value of preoperative thallium-201 (201Tl) SPECT as a predictor of outcome in malignant glioma.
  51. Zhou Y, MacKinnon R. Ion binding affinity in the cavity of the KcsA potassium channel. Biochemistry. 2004;43:4978-82 pubmed
    ..These results are consistent with a fairly large (more negative than -100 mV) electrostatic potential inside the cavity, and they also imply the presence of a weak nonelectrostatic component to a cation's interaction with the cavity...
  52. Ghannoum M, Nolin T, Goldfarb D, Roberts D, Mactier R, Mowry J, et al. Extracorporeal treatment for thallium poisoning: recommendations from the EXTRIP Workgroup. Clin J Am Soc Nephrol. 2012;7:1682-90 pubmed publisher
    ..The EXtracorporeal TReatments In Poisoning (EXTRIP) workgroup was formed to provide recommendations on the use of extracorporeal treatment (ECTR) in poisoning. To test and validate its methods, the workgroup reviewed data for thallium (Tl).
  53. Hansen U, Cakan O, Abshagen Keunecke M, Farokhi A. Gating models of the anomalous mole-fraction effect of single-channel current in Chara. J Membr Biol. 2003;192:45-63 pubmed
    ..These ions may reside in the pore itself or outside...