calcium

Summary

Summary: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.

Top Publications

  1. Diakogiannaki E, Pais R, Tolhurst G, Parker H, Horscroft J, Rauscher B, et al. Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor. Diabetologia. 2013;56:2688-96 pubmed publisher
    ..Two sensory mechanisms involving peptide transporter-1 (PEPT1) and the calcium-sensing receptor (CaSR) were distinguishable...
  2. Witze E, Connacher M, Houel S, Schwartz M, Morphew M, Reid L, et al. Wnt5a directs polarized calcium gradients by recruiting cortical endoplasmic reticulum to the cell trailing edge. Dev Cell. 2013;26:645-57 pubmed publisher
    ..Thus, Wnt5a controls directional movement by recruiting cortical ER to mobilize a rear-directed, localized Ca2+ signal, activating actomyosin contraction and adhesion disassembly for membrane retraction. ..
  3. Pan X, Liu J, Nguyen T, Liu C, Sun J, Teng Y, et al. The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter. Nat Cell Biol. 2013;15:1464-72 pubmed publisher
    Mitochondrial calcium has been postulated to regulate a wide range of processes from bioenergetics to cell death. Here, we characterize a mouse model that lacks expression of the recently discovered mitochondrial calcium uniporter (MCU)...
  4. Young B, Cooper E, McIntyre A, Kent T, Witter F, Harris Z, et al. Placental vitamin D receptor (VDR) expression is related to neonatal vitamin D status, placental calcium transfer, and fetal bone length in pregnant adolescents. FASEB J. 2014;28:2029-37 pubmed publisher
    ..purpose of the study was to identify determinants of placental vitamin D receptor (VDR) expression and placental calcium (Ca) transfer among pregnant adolescents. Placental tissue was obtained in 94 adolescents (?18 yr) at term...
  5. Morieri G, Martinez E, Jarynowski A, Driguez H, Morris R, Oldroyd G, et al. Host-specific Nod-factors associated with Medicago truncatula nodule infection differentially induce calcium influx and calcium spiking in root hairs. New Phytol. 2013;200:656-62 pubmed publisher
    ..Nod factors induce two different calcium responses: intra-nuclear calcium oscillations and a calcium influx at the root hair tip...
  6. Pacini L, Suffredini S, Ponti D, Coppini R, Frati G, Ragona G, et al. Altered calcium regulation in isolated cardiomyocytes from Egr-1 knock-out mice. Can J Physiol Pharmacol. 2013;91:1135-42 pubmed publisher
    ..and molecular properties of left ventricular cardiomyocytes (VCM) by using patch-clamp technique, intracellular calcium measurements, real-time PCR, and Western blot...
  7. Jin X, Shah S, Liu Y, Zhang H, Lees M, Fu Z, et al. Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor. Sci Signal. 2013;6:ra73 pubmed publisher
    ..The junctional signaling complex enabled ANO1-mediated excitation in response to specific Ca(2+)signals rather than to global changes in intracellular Ca(2+). ..
  8. Villegas R, Martinez N, Lillo J, Pihan P, Hernandez D, Twiss J, et al. Calcium release from intra-axonal endoplasmic reticulum leads to axon degeneration through mitochondrial dysfunction. J Neurosci. 2014;34:7179-89 pubmed publisher
    ..Critical steps in this degenerative process are still unknown. Here we show that calcium release from the axonal endoplasmic reticulum (ER) through ryanodine and IP3 channels activates the mitochondrial ..
  9. Parkinson K, Baines A, Keller T, Gruenheit N, Bragg L, North R, et al. Calcium-dependent regulation of Rab activation and vesicle fusion by an intracellular P2X ion channel. Nat Cell Biol. 2014;16:87-98 pubmed publisher
    ..Here we describe a mechanism by which localized calcium release through a vesicular ion channel controls Rab GTPase activity...

More Information

Publications93

  1. Wang L, Yang X, Li S, Wang Z, Liu Y, Feng J, et al. Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake. EMBO J. 2014;33:594-604 pubmed publisher
    Mitochondrial calcium uptake is a critical event in various cellular activities...
  2. Appleby P, Shabir S, Southgate J, Walker D. Cell-type-specific modelling of intracellular calcium signalling: a urothelial cell model. J R Soc Interface. 2013;10:20130487 pubmed publisher
    b>Calcium signalling plays a central role in regulating a wide variety of cell processes. A number of calcium signalling models exist in the literature that are capable of reproducing a variety of experimentally observed calcium transients...
  3. Wang Y, Ali Y, Lim C, Hong W, Pang Z, Han W. Insulin-stimulated leptin secretion requires calcium and PI3K/Akt activation. Biochem J. 2014;458:491-8 pubmed publisher
    ..We conclude that insulin stimulates leptin release through the PI3K/Akt pathway and that Ca2+ is required for robust Akt phosphorylation and leptin secretion. ..
  4. Yonkers K, Pearlstein T, Gotman N. A pilot study to compare fluoxetine, calcium, and placebo in the treatment of premenstrual syndrome. J Clin Psychopharmacol. 2013;33:614-20 pubmed publisher
    Serotonin reuptake inhibitors and calcium supplements ameliorate symptoms of premenstrual syndrome. A comparison of these agents to placebo may guide treatment selection...
  5. Roh S, Woo J, Lakshmana M, Uhlar C, Ankala V, Boggess T, et al. Mitochondrial dysfunction and calcium deregulation by the RanBP9-cofilin pathway. FASEB J. 2013;27:4776-89 pubmed publisher
    ..neurons that RanBP9 potentiates A?-induced reactive oxygen species (ROS) overproduction, apoptosis, and calcium deregulation...
  6. Kim B, Zhang X, Kan R, Cohen R, Mukai C, Travis A, et al. The role of MATER in endoplasmic reticulum distribution and calcium homeostasis in mouse oocytes. Dev Biol. 2014;386:331-9 pubmed publisher
    ..The calcium required for these oscillations is primarily derived from the endoplasmic reticulum (ER), which accumulates in ..
  7. Elliott E, McCarroll D, Hasumi H, Welsh C, Panissidi A, Jones N, et al. Trypanosoma brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes. Cardiovasc Res. 2013;100:325-35 pubmed publisher
    ..The current study exposed isolated ventricular cardiomyocytes and adult rat hearts to T. brucei to test whether trypanosomes can alter cardiac function independent of a systemic inflammatory/immune response...
  8. Wei LaPierre L, Carrell E, Boncompagni S, Protasi F, Dirksen R. Orai1-dependent calcium entry promotes skeletal muscle growth and limits fatigue. Nat Commun. 2013;4:2805 pubmed publisher
    ..We further show that STIM1 and Orai1 proteins co-localize within the triad junction but do not exist in a preassembled context. These results show that Orai1-dependent SOCE has an important physiological role in muscles of adult mice. ..
  9. Delling M, DeCaen P, Doerner J, Febvay S, Clapham D. Primary cilia are specialized calcium signalling organelles. Nature. 2013;504:311-4 pubmed publisher
    ..Here we show that cilia are a unique calcium compartment regulated by a heteromeric TRP channel, PKD1L1-PKD2L1, in mice and humans...
  10. Llorente Folch I, Rueda C, Amigo I, del Arco A, Saheki T, Pardo B, et al. Calcium-regulation of mitochondrial respiration maintains ATP homeostasis and requires ARALAR/AGC1-malate aspartate shuttle in intact cortical neurons. J Neurosci. 2013;33:13957-71, 13971a pubmed publisher
    ..The results suggest a requirement for ARALAR-MAS in priming pyruvate entry in mitochondria as a step needed to activate respiration by Ca2+ in response to moderate workloads. ..
  11. Luo M, Anderson M. Mechanisms of altered Ca²? handling in heart failure. Circ Res. 2013;113:690-708 pubmed publisher
    ..This review focuses on the molecular mechanisms of defective Ca²? cycling in heart failure and considers how fundamental understanding of these pathways may translate into novel and innovative therapies. ..
  12. Kinoshita Y, Hori M, Taguchi M, Watanabe S, Fukumoto S. Functional activities of mutant calcium-sensing receptors determine clinical presentations in patients with autosomal dominant hypocalcemia. J Clin Endocrinol Metab. 2014;99:E363-8 pubmed publisher
    ..dominant hypocalcemia (ADH) is a congenital isolated hypoparathyroidism caused by activating mutations in the calcium-sensing receptor (CASR) gene...
  13. Yang P, Baciu P, Kerrigan B, Etheridge M, Sung E, Toimil B, et al. Retinal pigment epithelial cell death by the alternative complement cascade: role of membrane regulatory proteins, calcium, PKC, and oxidative stress. Invest Ophthalmol Vis Sci. 2014;55:3012-21 pubmed publisher
    ..Cellular response to complement activation was examined by measurement of intracellular calcium and adenosine triphosphate (ATP) release...
  14. Bonora M, Giorgi C, Bononi A, Marchi S, Patergnani S, Rimessi A, et al. Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes. Nat Protoc. 2013;8:2105-18 pubmed publisher
    ..Aequorea victoria produces a 22-kDa protein named aequorin that has had an important role in the study of calcium (Ca(2+)) signaling...
  15. Zhao J, Chen H, Ojcius D, Zhao X, Sun D, Ge Y, et al. Identification of Leptospira interrogans phospholipase C as a novel virulence factor responsible for intracellular free calcium ion elevation during macrophage death. PLoS ONE. 2013;8:e75652 pubmed publisher
    ..Ca(2+) release from the endoplasmic reticulum, as seen by suppression of [Ca(2+)]i elevation when receptor-gated calcium channels were blocked or P2X7 was depleted...
  16. Hoffman N, Chandramoorthy H, Shamugapriya S, Zhang X, Rajan S, Mallilankaraman K, et al. MICU1 motifs define mitochondrial calcium uniporter binding and activity. Cell Rep. 2013;5:1576-1588 pubmed publisher
    Resting mitochondrial matrix Ca(2+) is maintained through a mitochondrial calcium uptake 1 (MICU1)-established threshold inhibition of mitochondrial calcium uniporter (MCU) activity...
  17. Raffaello A, De Stefani D, Sabbadin D, Teardo E, Merli G, Picard A, et al. The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit. EMBO J. 2013;32:2362-76 pubmed publisher
    Mitochondrial calcium uniporter (MCU) channel is responsible for Ruthenium Red-sensitive mitochondrial calcium uptake...
  18. Long T, Su J, Tang W, Luo Z, Liu S, Liu Z, et al. A novel interaction between calcium-modulating cyclophilin ligand and Basigin regulates calcium signaling and matrix metalloproteinase activities in human melanoma cells. Cancer Lett. 2013;339:93-101 pubmed publisher
    Intracellular free calcium is a ubiquitous second messenger regulating a multitude of normal and pathogenic cellular responses, including the development of melanoma...
  19. Zhao Z, Yin Y, Wang Z, Fang R, Wu H, Jiang M, et al. Arctigenin exhibits relaxation effect on bronchus by affecting transmembrane flow of calcium. Biol Trace Elem Res. 2013;156:181-7 pubmed publisher
    ..This study aimed to investigate how arctigenin regulates bronchus tone and calcium ion (Ca(2+)) flow...
  20. Stathopulos P, Schindl R, Fahrner M, Zheng L, Gasmi Seabrook G, Muik M, et al. STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry. Nat Commun. 2013;4:2963 pubmed publisher
    Orai1 calcium channels in the plasma membrane are activated by stromal interaction molecule-1 (STIM1), an endoplasmic reticulum calcium sensor, to mediate store-operated calcium entry (SOCE)...
  21. Annerbo M, Hultin H, Stalberg P, Hellman P. Left-shifted relation between calcium and parathyroid hormone in Graves' disease. J Clin Endocrinol Metab. 2014;99:545-51 pubmed publisher
    Patients with Graves' disease (GD) have disturbances in calcium regulation with manifestations such as postoperative hypocalcemia. We have investigated the thyroid as well as the parathyroid function in detail...
  22. Li X, Wu F, Xu R, Hu W, Jiang D, Ji C, et al. Acid-sensing ion channel 1a-mediated calcium influx regulates apoptosis of endplate chondrocytes in intervertebral discs. Expert Opin Ther Targets. 2014;18:1-14 pubmed publisher
    ..However, little is known about the role of ASIC1a in endplate chondrocytes in intervertebral discs (IVDs)...
  23. Xu J, Ren Y, Xu X, Chen J, Li Y, Gan W, et al. Schistosoma japonicum tegumental protein 20.8, role in reproduction through its calcium binding ability. Parasitol Res. 2014;113:491-7 pubmed publisher
    ..In electrophoretic mobility shift assay, the protein could bind calcium iron in neutral condition...
  24. Zhang Q, Ramracheya R, Lahmann C, Tarasov A, Bengtsson M, Braha O, et al. Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes. Cell Metab. 2013;18:871-82 pubmed publisher
    ..These data suggest that impaired metabolic control of the KATP channels underlies the defective glucose regulation of glucagon secretion in type 2 diabetes. ..
  25. Gerasimenko J, Gryshchenko O, Ferdek P, Stapleton E, Hébert T, Bychkova S, et al. Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy. Proc Natl Acad Sci U S A. 2013;110:13186-91 pubmed publisher
  26. Schumacher M, Lode A, Helth A, Gelinsky M. A novel strontium(II)-modified calcium phosphate bone cement stimulates human-bone-marrow-derived mesenchymal stem cell proliferation and osteogenic differentiation in vitro. Acta Biomater. 2013;9:9547-57 pubmed publisher
    In the present study, the in vitro effects of novel strontium-modified calcium phosphate bone cements (SrCPCs), prepared using two different approaches on human-bone-marrow-derived mesenchymal stem cells (hMSCs), were evaluated...
  27. Hyrc K, MINTA A, Escamilla P, Chan P, Meshik X, Goldberg M. Synthesis and properties of Asante Calcium Red--a novel family of long excitation wavelength calcium indicators. Cell Calcium. 2013;54:320-33 pubmed publisher
    Although many synthetic calcium indicators are available, a search for compounds with improved characteristics continues...
  28. Chu Y, Fioravante D, Leitges M, Regehr W. Calcium-dependent PKC isoforms have specialized roles in short-term synaptic plasticity. Neuron. 2014;82:859-71 pubmed publisher
    ..which have distinct functional consequences, reflect unexpected differential actions of closely related calcium-dependent PKC isoforms...
  29. Volpe G, Tang A, Polak J, Mangili A, Skinner S, Wanke C. Progression of carotid intima-media thickness and coronary artery calcium over 6 years in an HIV-infected cohort. J Acquir Immune Defic Syndr. 2013;64:51-7 pubmed publisher
    ..To evaluate changes in cardiovascular disease risk surrogate markers in a longitudinal cohort of HIV-infected adults over 6 years...
  30. Xie W, Santulli G, Guo X, Gao M, Chen B, Marks A. Imaging atrial arrhythmic intracellular calcium in intact heart. J Mol Cell Cardiol. 2013;64:120-3 pubmed publisher
    ..Reduction of SR Ca(2+) leak via RyR2 by acute treatment with S107 reduced both Ca(2+) alternans and Ca(2+) waves, and prevented atrial arrhythmias. ..
  31. Takaya J, Iharada A, Okihana H, Kaneko K. A calcium-deficient diet in pregnant, nursing rats induces hypomethylation of specific cytosines in the 11?-hydroxysteroid dehydrogenase-1 promoter in pup liver. Nutr Res. 2013;33:961-70 pubmed publisher
    ..We hypothesized that pregnant females that were fed a calcium (Ca)-deficient diet would have offspring with altered hepatic glucocorticoid-related gene expression and altered ..
  32. Ghollasi M, Ghanbari Safari M, Khajeh K. Improvement of thermal stability of a mutagenised ?-amylase by manipulation of the calcium-binding site. Enzyme Microb Technol. 2013;53:406-13 pubmed publisher
    ..mutagenesis of an ?-amylase isolated from Bacillus megaterium WHO has been performed to evaluate the roles of the calcium binding site residues in enzyme thermostability...
  33. Mutig N, Geers Knoerr C, Piep B, Pahuja A, Vogt P, Brenner B, et al. Lipoteichoic acid from Staphylococcus aureus directly affects cardiomyocyte contractility and calcium transients. Mol Immunol. 2013;56:720-8 pubmed publisher
    ..This study was designed to evaluate the effects of LTA on contractile properties and calcium-transients of isolated adult rat cardiomyocytes...
  34. Rodriguez Moyano M, Diaz I, Dionisio N, Zhang X, Ávila Médina J, Calderón Sanchez E, et al. Urotensin-II promotes vascular smooth muscle cell proliferation through store-operated calcium entry and EGFR transactivation. Cardiovasc Res. 2013;100:297-306 pubmed publisher
    ..This study aimed to determine the role of calcium (Ca(2+))-dependent signalling and alternative signalling pathways in UII-evoked VSMCs proliferation focusing on ..
  35. Borysova L, Wray S, Eisner D, Burdyga T. How calcium signals in myocytes and pericytes are integrated across in situ microvascular networks and control microvascular tone. Cell Calcium. 2013;54:163-74 pubmed publisher
    ..Increases of Ca2+ in pericytes and myocytes constrict all vessels except capillaries. These data reveal the structural and signalling specializations allowing blood flow to be regulated by myocytes and pericytes...
  36. Bajić A, Spasic M, Andjus P, Savic D, Parabucki A, Nikolic Kokic A, et al. Fluctuating vs. continuous exposure to H?O?: the effects on mitochondrial membrane potential, intracellular calcium, and NF-?B in astroglia. PLoS ONE. 2013;8:e76383 pubmed publisher
    ..activity - respiration, reducing capacity, and superoxide production, as well as intracellular ATP, intracellular calcium, and NF-?B activation...
  37. Sheng L, Leshchyns ka I, Sytnyk V. Cell adhesion and intracellular calcium signaling in neurons. Cell Commun Signal. 2013;11:94 pubmed publisher
    ..Molecular mechanisms linking CAMs to VDCCs and intracellular Ca2+ stores in neurons are discussed. ..
  38. Monasky M, Taglieri D, Henze M, Warren C, Utter M, Soergel D, et al. The ?-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium. Am J Physiol Heart Circ Physiol. 2013;305:H856-66 pubmed publisher
    ..Selective activation of ?-arrestin-dependent pathways may provide advantages over conventional AT1R blockers. ..
  39. Asemi Z, Samimi M, Heidarzadeh Z, Khorrammian H, Tabassi Z. A randomized controlled clinical trial investigating the effect of calcium supplement plus low-dose aspirin on hs-CRP, oxidative stress and insulin resistance in pregnant women at risk for pre-eclampsia. Pak J Biol Sci. 2012;15:469-76 pubmed
    ..There is some evidence to suggest that calcium supplement and aspirin can reduce the risk of the disorder...
  40. Babich A, Burkhardt J. Coordinate control of cytoskeletal remodeling and calcium mobilization during T-cell activation. Immunol Rev. 2013;256:80-94 pubmed publisher
    ..reticulum stores, and a second phase involving STIM 1 (stromal interaction molecule 1) clustering and CRAC (calcium release activated calcium) channel activation. Cytoskeletal dynamics promote both phases...
  41. Shende P, Deshmukh K, Trotta F, Caldera F. Novel cyclodextrin nanosponges for delivery of calcium in hyperphosphatemia. Int J Pharm. 2013;456:95-100 pubmed publisher
    ..In this work, new cyclodextrin-based nanosponges of calcium carbonate were prepared by polymer condensation method to release the calcium in controlled manner in the ..
  42. Tibau E, Valencia M, Soriano J. Identification of neuronal network properties from the spectral analysis of calcium imaging signals in neuronal cultures. Front Neural Circuits. 2013;7:199 pubmed publisher
    ..In this work we monitor the development of neuronal cultures, and record their activity using calcium fluorescence imaging...
  43. Dolensek J, Stožer A, Skelin Klemen M, Miller E, Slak Rupnik M. The relationship between membrane potential and calcium dynamics in glucose-stimulated beta cell syncytium in acute mouse pancreas tissue slices. PLoS ONE. 2013;8:e82374 pubmed publisher
    ..recorded membrane potential oscillations in beta cells are associated with in-phase oscillatory cytosolic calcium activity ([Ca(2+)]i) measured with fluorescent probes...
  44. Tang D, Fang Y, Liu Z, Wu Y, Wang X, Zhao S, et al. The disturbances of endoplasmic reticulum calcium homeostasis caused by increased intracellular reactive oxygen species contributes to fragmentation in aged porcine oocytes. Biol Reprod. 2013;89:124 pubmed publisher
    ..We conclude that the increased intracellular ROS damaged the ER clusters and ER Ca(2+) homeostasis, resulting in a disorder in ooplasmic free Ca(2+), which caused the fragmentations seen in porcine MII oocytes during aging. ..
  45. Redpath C, Bou Khalil M, Drozdzal G, Radisic M, McBride H. Mitochondrial hyperfusion during oxidative stress is coupled to a dysregulation in calcium handling within a C2C12 cell model. PLoS ONE. 2013;8:e69165 pubmed publisher
    ..abruptly induces rapid conduction between atrial myocytes which is associated with oxidative stress and abnormal calcium handling. Unfortunately this new equilibrium promotes perpetuation of the arrhythmia...
  46. Di Tomo P, Pipino C, Lanuti P, Morabito C, Pierdomenico L, Sirolli V, et al. Calcium sensing receptor expression in ovine amniotic fluid mesenchymal stem cells and the potential role of R-568 during osteogenic differentiation. PLoS ONE. 2013;8:e73816 pubmed publisher
    ..b>Calcium Sensing Receptor (CaSR), a G protein-coupled receptor able to bind calcium ions, plays a physiological role in ..
  47. Pinheiro P, de Wit H, Walter A, Groffen A, Verhage M, Sørensen J. Doc2b synchronizes secretion from chromaffin cells by stimulating fast and inhibiting sustained release. J Neurosci. 2013;33:16459-70 pubmed publisher
    Synaptotagmin-1 and -7 constitute the main calcium sensors mediating SNARE-dependent exocytosis in mouse chromaffin cells, but the role of a closely related calcium-binding protein, Doc2b, remains enigmatic...
  48. Akin B, Hurley T, Chen Z, Jones L. The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum. J Biol Chem. 2013;288:30181-91 pubmed publisher
    ..This new structure represents one of the key unsolved conformational states of SERCA and provides a structural explanation for how dephosphorylated PLB decreases Ca(2+) affinity and depresses cardiac contractility. ..
  49. Scholl T, Chen X, Stein T. Maternal calcium metabolic stress and fetal growth. Am J Clin Nutr. 2014;99:918-25 pubmed publisher
    Suboptimal maternal calcium intake and vitamin D status may or may not adversely influence fetal growth.
  50. Rubio Moscardo F, Setó Salvia N, Pera M, Bosch Morató M, Plata C, Belbin O, et al. Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis. PLoS ONE. 2013;8:e74203 pubmed publisher
    b>Calcium signaling in the brain is fundamental to the learning and memory process and there is evidence to suggest that its dysfunction is involved in the pathological pathways underlying Alzheimer's disease (AD)...
  51. Jilani K, Enkel S, Bissinger R, Almilaji A, Abed M, Lang F. Fluoxetine induced suicidal erythrocyte death. Toxins (Basel). 2013;5:1230-43 pubmed publisher
    ..The effect on annexin V binding was significantly blunted, but not abolished, in the absence of extracellular Ca2+. In conclusion, fluoxetine stimulates eryptosis, an effect at least in part due to increase of cytosolic Ca2+ activity. ..
  52. Ngo Q, Vogler H, Lituiev D, Nestorova A, Grossniklaus U. A calcium dialog mediated by the FERONIA signal transduction pathway controls plant sperm delivery. Dev Cell. 2014;29:491-500 pubmed publisher
    ..We discovered that the synergids control this process by coordinating their distinct calcium signatures in response to the calcium dynamics and growth behavior of the PT...
  53. Melachroinou K, Xilouri M, Emmanouilidou E, Masgrau R, Papazafiri P, Stefanis L, et al. Deregulation of calcium homeostasis mediates secreted ?-synuclein-induced neurotoxicity. Neurobiol Aging. 2013;34:2853-65 pubmed publisher
    ..In the current study, we show that application of secreted AS alters membrane fluidity and increases calcium (Ca2+) entry. This influx is reduced on pharmacological inhibition of voltage-operated Ca2+ channels...
  54. Belkaya S, Murray S, Eitson J, de la Morena M, Forman J, van Oers N. Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1. J Biol Chem. 2013;288:30752-62 pubmed publisher
    ..In hippocampal neurons, miR-185 targets both sarcoplasmic/endoplasmic reticulum calcium ATPase 2 and a novel Golgi inhibitor...
  55. Chang W, Radin B, McCurdy M. Calcium, magnesium, and phosphate abnormalities in the emergency department. Emerg Med Clin North Am. 2014;32:349-66 pubmed publisher
    Derangements of calcium, magnesium, and phosphate are associated with increased morbidity and mortality. These minerals have vital roles in the cellular physiology of the neuromuscular and cardiovascular systems...
  56. Jekl V, Redrobe S. Rabbit dental disease and calcium metabolism--the science behind divided opinions. J Small Anim Pract. 2013;54:481-90 pubmed publisher
    ..This article provides a review of the scientific literature and an overview of the peculiarities of calcium homeostasis in the rabbit in an attempt to draw together current thinking on the cause of dental disease...
  57. Klar R, Duarte R, Dix Peek T, Dickens C, Ferretti C, Ripamonti U. Calcium ions and osteoclastogenesis initiate the induction of bone formation by coral-derived macroporous constructs. J Cell Mol Med. 2013;17:1444-57 pubmed publisher
    Coral-derived calcium carbonate/hydroxyapatite macroporous constructs of the genus Goniopora with limited hydrothermal conversion to hydroxyapatite (7% HA/CC) initiate the induction of bone formation...
  58. Kenny E, Quinn S, Doyle S, Vink P, Van Eenennaam H, O Neill L. Bruton's tyrosine kinase mediates the synergistic signalling between TLR9 and the B cell receptor by regulating calcium and calmodulin. PLoS ONE. 2013;8:e74103 pubmed publisher
    ..Downstream of BTK we find that calcium acting via calmodulin is required for this process...
  59. Vocke K, Dauner K, Hahn A, Ulbrich A, Broecker J, Keller S, et al. Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels. J Gen Physiol. 2013;142:381-404 pubmed publisher
    b>Calcium-dependent chloride channels serve critical functions in diverse biological systems. Driven by cellular calcium signals, the channels codetermine excitatory processes and promote solute transport...
  60. Yuan H, Gao C, Chen Y, Jia M, Geng J, Zhang H, et al. Divalent cations modulate TMEM16A calcium-activated chloride channels by a common mechanism. J Membr Biol. 2013;246:893-902 pubmed publisher
    ..Maximally effective concentrations of Sr²? and Ni²? occluded activation of the TMEM16A current by Ca²?, which suggests that Ca²?, Sr²? and Ni²? all regulate the channel by the same mechanism...
  61. Novak P, Gorelik J, Vivekananda U, Shevchuk A, Ermolyuk Y, Bailey R, et al. Nanoscale-targeted patch-clamp recordings of functional presynaptic ion channels. Neuron. 2013;79:1067-77 pubmed publisher
    ..This semiautomated approach allows direct investigation of the distribution and properties of presynaptic ion channels at small central synapses. ..
  62. Leal S, Cardoso I, Valentine J, Gomes C. Calcium ions promote superoxide dismutase 1 (SOD1) aggregation into non-fibrillar amyloid: a link to toxic effects of calcium overload in amyotrophic lateral sclerosis (ALS)?. J Biol Chem. 2013;288:25219-28 pubmed publisher
    ..In this scenario, Ca(2+) may be considered as a pathogenic effector in the formation of ALS proteinaceous inclusions. ..
  63. Goffer Y, Xu D, Eberle S, D amour J, Lee M, TUKEY D, et al. Calcium-permeable AMPA receptors in the nucleus accumbens regulate depression-like behaviors in the chronic neuropathic pain state. J Neurosci. 2013;33:19034-44 pubmed publisher
    ..We find, in addition, that this increase in GluA1 levels leads to the formation of calcium-permeable AMPA receptors (CPARs)...
  64. Fukumori R, Takarada T, Nakazato R, Fujikawa K, Kou M, Hinoi E, et al. Selective inhibition by ethanol of mitochondrial calcium influx mediated by uncoupling protein-2 in relation to N-methyl-D-aspartate cytotoxicity in cultured neurons. PLoS ONE. 2013;8:e69718 pubmed publisher
    ..Here, we evaluated pharmacological profiles of ethanol on the NMDA-induced increase in mitochondrial Ca(2+) levels in cultured murine neocortical neurons...
  65. Bading H. Nuclear calcium signalling in the regulation of brain function. Nat Rev Neurosci. 2013;14:593-608 pubmed publisher
    ..b>Calcium signals that are induced by synaptic activity and propagate into the nucleus are a major route for synapse-to-..
  66. Guragain M, Lenaburg D, Moore F, Reutlinger I, Patrauchan M. Calcium homeostasis in Pseudomonas aeruginosa requires multiple transporters and modulates swarming motility. Cell Calcium. 2013;54:350-61 pubmed publisher
    ..Earlier we have shown that calcium (Ca(2+)) induces P. aeruginosa biofilm formation and production of virulence factors...
  67. Liu W, Zhao H, Wang Y, Jiang C, Xia P, Gu J, et al. Calcium-calmodulin signaling elicits mitochondrial dysfunction and the release of cytochrome c during cadmium-induced apoptosis in primary osteoblasts. Toxicol Lett. 2014;224:1-6 pubmed publisher
    ..We then showed that exposure to Cd transiently increased intracellular calcium ([Ca(2+)]i) levels for up to 1.5h, after which the levels returned to normal...
  68. Carlson H, Campbell R. Circular permutated red fluorescent proteins and calcium ion indicators based on mCherry. Protein Eng Des Sel. 2013;26:763-72 pubmed publisher
    Red fluorescent indicators for calcium ion (Ca(2+)) are preferable, relative to blue-shifted alternatives, for biological imaging applications due to the lower phototoxicity, lower autofluorescent background and deeper tissue penetration ..
  69. Bates R, Fees C, Holland W, Winger C, Batbayar K, Ancar R, et al. Activation of Src and release of intracellular calcium by phosphatidic acid during Xenopus laevis fertilization. Dev Biol. 2014;386:165-80 pubmed publisher
    ..stimulate phospholipase C-? (PLC-?) which increases inositol 1,4,5-trisphosphate (IP3) to release intracellular calcium ([Ca](i))...
  70. Chan J, Bhattacharyya D, Lassen K, Ruelas D, Greene W. Calcium/calcineurin synergizes with prostratin to promote NF-?B dependent activation of latent HIV. PLoS ONE. 2013;8:e77749 pubmed publisher
    ..However, cyclosporin A markedly inhibited the reactivation response. These results were reconciled when calcium signaling through calcineurin was shown to potentiate prostratin induced activation of NF-?B that in turn ..
  71. Peng A, Effertz T, Ricci A. Adaptation of mammalian auditory hair cell mechanotransduction is independent of calcium entry. Neuron. 2013;80:960-72 pubmed publisher
    ..This study investigates the calcium dependence of adaptation in the mammalian auditory system...
  72. David V, Dai B, Martin A, Huang J, Han X, Quarles L. Calcium regulates FGF-23 expression in bone. Endocrinology. 2013;154:4469-82 pubmed publisher
    b>Calcium has recently been shown to regulate fibroblast growth factor 23 (FGF-23), a bone-derived phosphate and vitamin D-regulating hormone...
  73. Hyser J, Utama B, Crawford S, Broughman J, Estes M. Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity. J Virol. 2013;87:13579-88 pubmed publisher
    Rotavirus nonstructural protein 4 (NSP4) induces dramatic changes in cellular calcium homeostasis...
  74. Zhang C, Huang Y, Jiang Y, Mulpuri N, Wei L, Hamelberg D, et al. Identification of an L-phenylalanine binding site enhancing the cooperative responses of the calcium-sensing receptor to calcium. J Biol Chem. 2014;289:5296-309 pubmed publisher
    Functional positive cooperative activation of the extracellular calcium ([Ca(2+)]o)-sensing receptor (CaSR), a member of the family C G protein-coupled receptors, by [Ca(2+)]o or amino acids elicits intracellular Ca(2+) ([Ca(2+)]i) ..
  75. Anwar H, Hepburn I, Nedelescu H, Chen W, De Schutter E. Stochastic calcium mechanisms cause dendritic calcium spike variability. J Neurosci. 2013;33:15848-67 pubmed publisher
    Bursts of dendritic calcium spikes play an important role in excitability and synaptic plasticity in many types of neurons...
  76. Alamilla J, Gillespie D. Maturation of calcium-dependent GABA, glycine, and glutamate release in the glycinergic MNTB-LSO pathway. PLoS ONE. 2013;8:e75688 pubmed publisher
    ..Developmental changes in calcium-dependent release are understood to be required to allow various auditory nuclei to follow high frequency ..
  77. Makhro A, Hänggi P, Goede J, Wang J, Brüggemann A, Gassmann M, et al. N-methyl-D-aspartate receptors in human erythroid precursor cells and in circulating red blood cells contribute to the intracellular calcium regulation. Am J Physiol Cell Physiol. 2013;305:C1123-38 pubmed publisher
    ..Thus functional NMDARs are present in erythroid precursor cells and in circulating RBCs. These receptors contribute to intracellular Ca(2+) homeostasis and modulate oxygen delivery to peripheral tissues. ..
  78. Patrushev I, Gavrilov N, Turlapov V, Semyanov A. Subcellular location of astrocytic calcium stores favors extrasynaptic neuron-astrocyte communication. Cell Calcium. 2013;54:343-9 pubmed publisher
    ..Thus, the anatomic data do not support communication involving Ca(2+) stores in tripartite synapses, but rather point to extrasynaptic communication. ..
  79. Choi H, Lee Y, Lee J, Shin H, Han H, Kim G. A simple bacterial transformation method using magnesium- and calcium-aminoclays. J Microbiol Methods. 2013;95:97-101 pubmed publisher
    ..In contrast, transformation efficiency was higher in S. mutans than that in E. coli XL1-Blue for calcium-aminoclay. It was also confirmed that each plasmid transformed into E. coli and S...
  80. Dalemo S, Eggertsen R, Hjerpe P, Jansson S, Almqvist E, Bengtsson Boström K. Long-term follow-up of patients with elevated serum calcium concentrations in Swedish primary care. Scand J Prim Health Care. 2013;31:248-54 pubmed publisher
    To follow up patients with elevated calcium concentrations after 10 years.
  81. Greensmith D. Ca analysis: an Excel based program for the analysis of intracellular calcium transients including multiple, simultaneous regression analysis. Comput Methods Programs Biomed. 2014;113:241-50 pubmed publisher
    ..I demonstrate that this program performs equally well as commercially available software, but has numerous advantages, namely creating a simplified, self-contained analysis workflow. ..
  82. Andersen C, Moestrup S. How calcium makes endocytic receptors attractive. Trends Biochem Sci. 2014;39:82-90 pubmed publisher
    ..Endosomal acidification and calcium efflux lead to the essential ligand-receptor affinity switch and separation...
  83. Borowiec A, Bidaux G, Tacine R, Dubar P, Pigat N, Delcourt P, et al. Are Orai1 and Orai3 channels more important than calcium influx for cell proliferation?. Biochim Biophys Acta. 2014;1843:464-72 pubmed publisher
    Transformed and tumoral cells share the characteristic of being able to proliferate even when external calcium concentration is very low...
  84. Post S, Nawijn M, Jonker M, Kliphuis N, van den Berge M, van Oosterhout A, et al. House dust mite-induced calcium signaling instigates epithelial barrier dysfunction and CCL20 production. Allergy. 2013;68:1117-25 pubmed publisher