beryllium

Summary

Summary: An element with the atomic symbol Be, atomic number 4, and atomic weight 9.01218. Short exposure to this element can lead to a type of poisoning known as BERYLLIOSIS.

Top Publications

  1. Chaudhary A, Sauer N, Gupta G. Beryllium-specific immune response in primary cells from healthy individuals. Toxicology. 2004;201:9-19 pubmed
    The effect of beryllium (Be) exposure has been extensively studied in patients with chronic beryllium disease (CBD). CBD patients carry mutated MHC class II alleles and show a hyperproliferation of T cells upon Be exposure...
  2. Henneberger P, Goe S, Miller W, Doney B, Groce D. Industries in the United States with airborne beryllium exposure and estimates of the number of current workers potentially exposed. J Occup Environ Hyg. 2004;1:648-59 pubmed
    Estimates of the number of workers in the United States occupationally exposed to beryllium were published in the 1970s and 1980s and ranged from 21,200 to 800,000...
  3. Schubauer Berigan M, Deddens J, Steenland K, Sanderson W, Petersen M. Adjustment for temporal confounders in a reanalysis of a case-control study of beryllium and lung cancer. Occup Environ Med. 2008;65:379-83 pubmed
    To evaluate potential confounding of the association between beryllium and lung cancer in a reanalysis of data from a published case-control study of workers at a beryllium processing facility.
  4. Milovanova T. Comparative analysis between CFSE flow cytometric and tritiated thymidine incorporation tests for beryllium sensitivity. Cytometry B Clin Cytom. 2007;72:265-75 pubmed
    In this study, we evaluated alternative possibility for CFSE beryllium flow cytometric test against beryllium blood lymphocyte proliferation test (BeLPT) as a standard radioactive clinical screening method to identify sensitization to ..
  5. Nirala S, Bhadauria M, Mathur R, Mathur A. Amelioration of beryllium induced alterations in hepatorenal biochemistry and ultramorphology by co-administration of tiferron and adjuvants. J Biomed Sci. 2007;14:331-45 pubmed
    ..p.) was evaluated to encounter toxicogenic events of beryllium exposure. Albino rats were exposed to beryllium nitrate (1 mg/kg, i.p...
  6. Bill J, Mack D, Falta M, Maier L, Sullivan A, Joslin F, et al. Beryllium presentation to CD4+ T cells is dependent on a single amino acid residue of the MHC class II beta-chain. J Immunol. 2005;175:7029-37 pubmed
    Chronic beryllium disease (CBD) is characterized by a CD4+ T cell alveolitis and granulomatous inflammation in the lung...
  7. Snyder J, Demchuk E, McCanlies E, Schuler C, Kreiss K, Andrew M, et al. Impact of negatively charged patches on the surface of MHC class II antigen-presenting proteins on risk of chronic beryllium disease. J R Soc Interface. 2008;5:749-58 pubmed
    Chronic beryllium disease (CBD) is a granulomatous lung disease that occurs primarily in workers who are exposed to beryllium dust or fumes...
  8. Schubauer Berigan M, Couch J, Petersen M, Carreon T, Jin Y, Deddens J. Cohort mortality study of workers at seven beryllium processing plants: update and associations with cumulative and maximum exposure. Occup Environ Med. 2011;68:345-53 pubmed publisher
    To extend follow-up of cause-specific mortality in workers at seven beryllium processing plants and to estimate associations between mortality risk and beryllium exposure.
  9. Levy P, Roth H, Deubner D. Exposure to beryllium and occurrence of lung cancer: findings from a cox proportional hazards analysis of data from a retrospective cohort mortality study. J Occup Environ Med. 2009;51:480-6 pubmed publisher
    The objective was to assess highly confounded patterns in a standardized mortality ratio (SMR) analysis of lung cancer in beryllium worker cohorts.

More Information

Publications62

  1. Amicosante M, Berretta F, Dweik R, Saltini C. Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells. Immunology. 2009;128:e462-70 pubmed publisher
    Berylliosis is driven by the accumulation in the lung of beryllium-specific T helper type 1 (Th1) cells recognizing beryllium as antigen when presented principally by human leucocyte antigen DP molecules carrying a glutamate at position ..
  2. Mack D, Lanham A, Palmer B, Maier L, Watts T, Fontenot A. 4-1BB enhances proliferation of beryllium-specific T cells in the lung of subjects with chronic beryllium disease. J Immunol. 2008;181:4381-8 pubmed
    ..We have shown that circulating beryllium-specific CD4(+) T cells from chronic beryllium disease patients remain CD28-dependent, while those present in ..
  3. Nirala S, Bhadauria M, Shukla S, Agrawal O, Mathur A, Li P, et al. Pharmacological intervention of tiferron and propolis to alleviate beryllium-induced hepatorenal toxicity. Fundam Clin Pharmacol. 2008;22:403-15 pubmed publisher
    ..to encounter the characteristic biochemical and ultra-morphological alterations following subchronic exposure to beryllium. Female albino rats were challenged with beryllium nitrate (1 mg/kg, i.p...
  4. Sawyer R, Day B, Fadok V, Chiarappa Zucca M, Maier L, Fontenot A, et al. Beryllium-ferritin: lymphocyte proliferation and macrophage apoptosis in chronic beryllium disease. Am J Respir Cell Mol Biol. 2004;31:470-7 pubmed
    A beryllium (Be)-ferritin adduct containing 270 pm of Be stimulated proliferation of bronchoalveolar lavage (BAL) lymphocytes from subjects with chronic beryllium disease (CBD) at concentrations 5-6 logs lower than the amounts of ..
  5. Madl A, Unice K, Brown J, Kolanz M, Kent M. Exposure-response analysis for beryllium sensitization and chronic beryllium disease among workers in a beryllium metal machining plant. J Occup Environ Hyg. 2007;4:448-66 pubmed
    The current occupational exposure limit (OEL) for beryllium has been in place for more than 50 years and was believed to be protective against chronic beryllium disease (CBD) until studies in the 1990s identified beryllium sensitization (..
  6. Sato H, Silveira L, Fingerlin T, Dockstader K, Gillespie M, Lagan A, et al. TNF polymorphism and bronchoalveolar lavage cell TNF-alpha levels in chronic beryllium disease and beryllium sensitization. J Allergy Clin Immunol. 2007;119:687-96 pubmed
    b>Beryllium stimulates TNF-alpha from chronic beryllium disease (CBD) bronchoalveolar lavage (BAL) cells.
  7. Fontenot A, Maier L. Genetic susceptibility and immune-mediated destruction in beryllium-induced disease. Trends Immunol. 2005;26:543-9 pubmed
    Chronic beryllium disease (CBD) is a hypersensitivity disorder caused by beryllium exposure in the workplace and is characterized by the accumulation of beryllium-specific CD4(+) T cells in the lung and granulomatous inflammation...
  8. Day G, Stefaniak A, Weston A, Tinkle S. Beryllium exposure: dermal and immunological considerations. Int Arch Occup Environ Health. 2006;79:161-4 pubmed
    People exposed to beryllium compounds are at increased risk of developing beryllium sensitization and chronic beryllium disease (CBD)...
  9. Palmer B, Mack D, Martin A, Gillespie M, Mroz M, Maier L, et al. Up-regulation of programmed death-1 expression on beryllium-specific CD4+ T cells in chronic beryllium disease. J Immunol. 2008;180:2704-12 pubmed
    Chronic beryllium disease (CBD) is caused by workplace exposure to beryllium and is characterized by the accumulation of memory CD4+ T cells in the lung...
  10. Nilsen A, Vik R, Behrens C, Drabløs P, Espevik T. Beryllium sensitivity among workers at a Norwegian aluminum smelter. Am J Ind Med. 2010;53:724-32 pubmed publisher
    Sensitivity to beryllium was investigated among workers at an aluminum smelter in Norway as a consequence of the findings in an occupational exposure survey.
  11. McCanlies E, Yucesoy B, Mnatsakanova A, Slaven J, Andrew M, Frye B, et al. Association between IL-1A single nucleotide polymorphisms and chronic beryllium disease and beryllium sensitization. J Occup Environ Med. 2010;52:680-4 pubmed publisher
    To determine if single nucleotide polymorphisms (SNPs) in interleukin (IL) IL-1A, IL-1B, IL-1RN, IL-2, IL-9, and IL-9R were associated with chronic beryllium disease (CBD) and beryllium sensitization (BeS).
  12. Sackett H, Maier L, Silveira L, Mroz M, Ogden L, Murphy J, et al. Beryllium medical surveillance at a former nuclear weapons facility during cleanup operations. J Occup Environ Med. 2004;46:953-61 pubmed
    Despite increasing need to remediate beryllium-contaminated buildings in industry, little is known about the magnitude of risk associated with beryllium abatement or the merits of beryllium medical surveillance for cleanup workers...
  13. Strupp C. Beryllium metal II. a review of the available toxicity data. Ann Occup Hyg. 2011;55:43-56 pubmed publisher
    b>Beryllium metal was classified in Europe collectively with beryllium compounds, e.g. soluble salts. Toxicological equivalence was assumed despite greatly differing physicochemical properties...
  14. Van Dyke M, Martyny J, Mroz M, Silveira L, Strand M, Cragle D, et al. Exposure and genetics increase risk of beryllium sensitisation and chronic beryllium disease in the nuclear weapons industry. Occup Environ Med. 2011;68:842-8 pubmed publisher
    b>Beryllium sensitisation (BeS) and chronic beryllium disease (CBD) are caused by exposure to beryllium with susceptibility affected by at least one well-studied genetic host factor, a glutamic acid residue at position 69 (E69) of the HLA-..
  15. Cummings K, Deubner D, Day G, Henneberger P, Kitt M, Kent M, et al. Enhanced preventive programme at a beryllium oxide ceramics facility reduces beryllium sensitisation among new workers. Occup Environ Med. 2007;64:134-40 pubmed
    A 1998 survey at a beryllium oxide ceramics manufacturing facility found that 10% of workers hired in the previous 6 years had beryllium sensitisation as determined by the beryllium lymphocyte proliferation test (BeLPT)...
  16. Bowerman N, Falta M, Mack D, Kappler J, Fontenot A. Mutagenesis of beryllium-specific TCRs suggests an unusual binding topology for antigen recognition. J Immunol. 2011;187:3694-703 pubmed publisher
    ..cell recognition, alanine screens were performed on a set of Be-specific TCRs derived from the lung of a chronic beryllium disease patient. These TCRs are HLA-DP2-restricted and express nearly identical TCR V?5...
  17. Boffetta P, Fryzek J, Mandel J. Occupational exposure to beryllium and cancer risk: a review of the epidemiologic evidence. Crit Rev Toxicol. 2012;42:107-18 pubmed publisher
    There is controversy on whether occupational exposure to beryllium causes lung cancer. We conducted a systematic review of epidemiologic studies on cancer among workers exposed to beryllium, including a study of seven U.S...
  18. Falta M, Pinilla C, Mack D, Tinega A, Crawford F, Giulianotti M, et al. Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease. J Exp Med. 2013;210:1403-18 pubmed
    Chronic beryllium disease (CBD) is a granulomatous disorder characterized by an influx of beryllium (Be)-specific CD4? T cells into the lung...
  19. Schubauer Berigan M, Deddens J, Couch J, Petersen M. Risk of lung cancer associated with quantitative beryllium exposure metrics within an occupational cohort. Occup Environ Med. 2011;68:354-60 pubmed publisher
    b>Beryllium has been identified as a human carcinogen on the basis of animal and epidemiological studies. The authors recently reported updated associations between lung cancer and beryllium exposure in a large, pooled occupational cohort...
  20. El Beshbishy H, Hassan M, Aly H, Doghish A, Alghaithy A. Crocin "saffron" protects against beryllium chloride toxicity in rats through diminution of oxidative stress and enhancing gene expression of antioxidant enzymes. Ecotoxicol Environ Saf. 2012;83:47-54 pubmed publisher
    b>Beryllium chloride (BeCl(2)) is a highly toxic substance that accumulates in different tissues after absorption. The purpose of this study was to investigate protective role of crocin against BeCl(2)-intoxication in rats...
  21. Thomas C, Deubner D, Stanton M, Kreiss K, Schuler C. Long-term efficacy of a program to prevent beryllium disease. Am J Ind Med. 2013;56:733-41 pubmed publisher
    In 2000, a manufacturer of beryllium materials and products introduced a comprehensive program to prevent beryllium sensitization and chronic beryllium disease (CBD)...
  22. Cullen M. Screening for chronic beryllium disease: one hurdle down, two to go. Am J Respir Crit Care Med. 2005;171:3-4 pubmed
  23. Nirala S, Bhadauria M. Synergistic effects of ferritin and propolis in modulation of beryllium induced toxicogenic alterations. Food Chem Toxicol. 2008;46:3069-79 pubmed publisher
    ..p.) and propolis (honeybee hive product; 200mg/kg, p.o.) was analyzed to encounter the beryllium induced biochemical and ultra morphological alterations...
  24. Stefaniak A, Chipera S, Day G, Sabey P, Dickerson R, Sbarra D, et al. Physicochemical characteristics of aerosol particles generated during the milling of beryllium silicate ores: implications for risk assessment. J Toxicol Environ Health A. 2008;71:1468-81 pubmed publisher
    Inhalation of beryllium dusts generated during milling of ores and cutting of beryl-containing gemstones is associated with development of beryllium sensitization and low prevalence of chronic beryllium disease (CBD)...
  25. Day G, Dufresne A, Stefaniak A, Schuler C, Stanton M, Miller W, et al. Exposure pathway assessment at a copper-beryllium alloy facility. Ann Occup Hyg. 2007;51:67-80 pubmed
    Controlling beryllium inhalation exposures to comply with regulatory levels (2 micro g m(-3) of air) does not appear to prevent beryllium sensitization and chronic beryllium disease (CBD)...
  26. Fontenot A, Keizer T, McCleskey M, Mack D, Meza Romero R, Huan J, et al. Recombinant HLA-DP2 binds beryllium and tolerizes beryllium-specific pathogenic CD4+ T cells. J Immunol. 2006;177:3874-83 pubmed
    Chronic beryllium disease is a lung disorder caused by beryllium exposure in the workplace and is characterized by granulomatous inflammation and the accumulation of beryllium-specific, HLA-DP2-restricted CD4+ T lymphocytes in the lung ..
  27. Kreiss K, Day G, Schuler C. Beryllium: a modern industrial hazard. Annu Rev Public Health. 2007;28:259-77 pubmed
    b>Beryllium exposure can cause a granulomatous lung disease in workers who develop a lymphocyte-mediated sensitization to the metal...
  28. Weston A, Snyder J, McCanlies E, Schuler C, Andrew M, Kreiss K, et al. Immunogenetic factors in beryllium sensitization and chronic beryllium disease. Mutat Res. 2005;592:68-78 pubmed
    Exposure to beryllium in the workplace can cause beryllium sensitization and chronic beryllium disease. Sensitization to beryllium can be detected in the laboratory using the beryllium lymphocyte proliferation test...
  29. Middleton D, Fink J, Kowalski P, Lewin M, Sinks T. Optimizing BeLPT criteria for beryllium sensitization. Am J Ind Med. 2008;51:166-72 pubmed publisher
    The beryllium lymphocyte proliferation test (BeLPT) is used to identify persons sensitized to beryllium...
  30. Silveira L, McCanlies E, Fingerlin T, Van Dyke M, Mroz M, Strand M, et al. Chronic beryllium disease, HLA-DPB1, and the DP peptide binding groove. J Immunol. 2012;189:4014-23 pubmed publisher
    Multiple epidemiologic studies demonstrate associations between chronic beryllium disease (CBD), beryllium sensitization (BeS), and HLA-DPB1 alleles with a glutamic acid residue at position 69 (E69)...
  31. Sawyer R, Abraham J, Daniloff E, Newman L. Secondary ion mass spectroscopy demonstrates retention of beryllium in chronic beryllium disease granulomas. J Occup Environ Med. 2005;47:1218-26 pubmed
    We hypothesized that beryllium (Be) might persist in lung granulomas in patients with chronic beryllium disease (CBD).
  32. Salehi F, Zayed J, Audusseau S, Muller C, Truchon G, Plamondon P, et al. Immunological responses in C3H/HeJ mice following nose-only inhalation exposure to different sizes of beryllium metal particles. J Appl Toxicol. 2009;29:61-8 pubmed publisher
    b>Beryllium is used in a wide variety of industries. Chronic beryllium disease is the most common occupational disease among workers following exposure to Be...
  33. Skaugset N, Ellingsen D, Dahl K, Martinsen I, Jordbekken L, Drabløs P, et al. Occupational exposure to beryllium in primary aluminium production. J Environ Monit. 2012;14:353-9 pubmed publisher
    ..Thus, the major amount of Be present in the work room atmosphere of Al smelter pot rooms will predominantly be present in combination with substantial amounts of water soluble Al, F and Na...
  34. Hollins D, McKinley M, Williams C, Wiman A, Fillos D, Chapman P, et al. Beryllium and lung cancer: a weight of evidence evaluation of the toxicological and epidemiological literature. Crit Rev Toxicol. 2009;39 Suppl 1:1-32 pubmed publisher
    The potential carcinogenicity of beryllium has been a topic of study since the mid-1940s. Since then, numerous scientific and regulatory bodies have assigned beryllium to various categories with respect to its carcinogenicity...
  35. McCleskey T, Buchner V, Field R, Scott B. Recent advances in understanding the biomolecular basis of chronic beryllium disease: a review. Rev Environ Health. 2009;24:75-115 pubmed
    ..conducted over the past decade that has advanced our knowledge of pulmonary diseases associated with exposure to beryllium that has provided a molecular-based understanding of the chemistry, immunopathology, and immunogenetics of ..
  36. Zhao J, Du G, Xiong Y, Wen Y, Bhadauria M, Nirala S. Attenuation of beryllium induced hepatorenal dysfunction and oxidative stress in rodents by combined effect of gallic acid and piperine. Arch Pharm Res. 2007;30:1575-83 pubmed
    ..o.) through their therapeutic potential and further evaluated them individually and in combination against beryllium-induced biochemical alterations and oxidative stress consequences in female albino rats...
  37. Harper M. A review of workplace aerosol sampling procedures and their relevance to the assessment of beryllium exposures. J Environ Monit. 2006;8:598-604 pubmed
    ..Some considerations important to the sampling of airborne particles containing beryllium with regard to the sampling conventions, the test protocols and sampler performance are discussed.
  38. Middleton D, Kowalski P. Advances in identifying beryllium sensitization and disease. Int J Environ Res Public Health. 2010;7:115-24 pubmed publisher
    b>Beryllium is a lightweight metal with unique qualities related to stiffness, corrosion resistance, and conductivity...
  39. Deubner D, Roth H, Levy P. Empirical evaluation of complex epidemiologic study designs: workplace exposure and cancer. J Occup Environ Med. 2007;49:953-9 pubmed
    ..Our aim was to evaluate empirically the performance of this complex study design...
  40. Silva S, Ganguly K, Fresquez T, Gupta G, McCleskey T, Chaudhary A. Beryllium alters lipopolysaccharide-mediated intracellular phosphorylation and cytokine release in human peripheral blood mononuclear cells. J Occup Environ Hyg. 2009;6:775-82 pubmed publisher
    b>Beryllium exposure in susceptible individuals leads to the development of chronic beryllium disease, a lung disorder marked by release of inflammatory cytokine and granuloma formation...
  41. Cummings K, Stefaniak A, Virji M, Kreiss K. A reconsideration of acute Beryllium disease. Environ Health Perspect. 2009;117:1250-6 pubmed publisher
    Although chronic beryllium disease (CBD) is clearly an immune-mediated granulomatous reaction to beryllium, acute beryllium disease (ABD) is commonly considered an irritative chemical phenomenon related to high exposures...
  42. Stefaniak A, Guilmette R, Day G, Hoover M, Breysse P, Scripsick R. Characterization of phagolysosomal simulant fluid for study of beryllium aerosol particle dissolution. Toxicol In Vitro. 2005;19:123-34 pubmed
    A simulant of phagolysosomal fluid is needed for beryllium particle dissolution research because intraphagolysosomal dissolution is believed to be a necessary step in the cellular immune response associated with development of chronic ..
  43. Nirala S, Bhadauria M, Mathur R, Mathur A. Influence of alpha-tocopherol, propolis and piperine on therapeutic potential of tiferron against beryllium induced toxic manifestations. J Appl Toxicol. 2008;28:44-54 pubmed
    ..o.) and piperine (10 mg kg(-1), p.o.) were evaluated individually and in combination against beryllium induced biochemical alterations and oxidative stress consequences...
  44. Sawyer R, Maier L. Chronic beryllium disease: an updated model interaction between innate and acquired immunity. Biometals. 2011;24:1-17 pubmed publisher
    During the last decade, there have been concerted efforts to reduce beryllium (Be) exposure in the workplace and thereby reduce potential cases of this occupational lung disorder...
  45. Coates S, Lehnert B, Sharma S, Kindell S, Gary R. Beryllium induces premature senescence in human fibroblasts. J Pharmacol Exp Ther. 2007;322:70-9 pubmed
    ..Here, we report that beryllium causes proliferation arrest with premature expression of the principal markers of senescence...
  46. Rosenman K, Rossman M, Hertzberg V, Reilly M, Rice C, Kanterakis E, et al. HLA class II DPB1 and DRB1 polymorphisms associated with genetic susceptibility to beryllium toxicity. Occup Environ Med. 2011;68:487-93 pubmed publisher
    Chronic beryllium disease (CBD) is a hypersensitivity granulomatous pulmonary disease caused by exposure to the metal beryllium (Be²?)...
  47. Hong Geller E, Pardington P, Cary R, Sauer N, Gupta G. Chemokine regulation in response to beryllium exposure in human peripheral blood mononuclear and dendritic cells. Toxicology. 2006;218:216-28 pubmed
    Exposure to beryllium (Be) induces a delayed-type hypersensitivity immune reaction in the lungs of susceptible individuals, which leads to the onset of Be sensitivity and Chronic Beryllium Disease (CBD)...
  48. Stange A, Furman F, Hilmas D. The beryllium lymphocyte proliferation test: Relevant issues in beryllium health surveillance. Am J Ind Med. 2004;46:453-62 pubmed
    The beryllium lymphocyte proliferation test (Be-LPT) measures beryllium-specific cellular immune response, and is useful in medical surveillance of beryllium sensitivity and chronic beryllium disease (CBD).
  49. Pott G, Palmer B, Sullivan A, Silviera L, Maier L, Newman L, et al. Frequency of beryllium-specific, TH1-type cytokine-expressing CD4+ T cells in patients with beryllium-induced disease. J Allergy Clin Immunol. 2005;115:1036-42 pubmed
    b>Beryllium sensitization is caused by exposure to beryllium in the workplace...
  50. Stanton M, Henneberger P, Kent M, Deubner D, Kreiss K, Schuler C. Sensitization and chronic beryllium disease among workers in copper-beryllium distribution centers. J Occup Environ Med. 2006;48:204-11 pubmed
    Little is known about the risk of sensitization and chronic beryllium disease (CBD) among workers performing limited processing of copper-beryllium alloys downstream of the primary beryllium industry...
  51. Middleton D, Lewin M, Kowalski P, Cox S, Kleinbaum D. The BeLPT: algorithms and implications. Am J Ind Med. 2006;49:36-44 pubmed
    The beryllium lymphocyte proliferation test (BeLPT) is used to identify persons with beryllium sensitization...
  52. Day G, Hoover M, Stefaniak A, Dickerson R, Peterson E, Esmen N, et al. Bioavailability of beryllium oxide particles: an in vitro study in the murine J774A.1 macrophage cell line model. Exp Lung Res. 2005;31:341-60 pubmed
    b>Beryllium metal and its oxide and alloys are materials of industrial significance with recognized adverse effects on worker health...
  53. Sawyer R, Dobis D, Goldstein M, Velsor L, Maier L, Fontenot A, et al. Beryllium-stimulated reactive oxygen species and macrophage apoptosis. Free Radic Biol Med. 2005;38:928-37 pubmed
    b>Beryllium (Be), the etiologic agent of chronic beryllium disease, is a toxic metal that induces apoptosis in human alveolar macrophages...