monovalent cations

Summary

Summary: Positively charged atoms, radicals or group of atoms with a valence of plus 1, which travel to the cathode or negative pole during electrolysis.

Top Publications

  1. Bakowski D, Parekh A. Monovalent cation permeability and Ca(2+) block of the store-operated Ca(2+) current I(CRAC )in rat basophilic leukemia cells. Pflugers Arch. 2002;443:892-902 pubmed
    Like voltage-operated Ca(2+) channels, store-operated CRAC channels become permeable to monovalent cations in the absence of external divalent cations...
  2. Andersson C, Mowbray S. Activation of ribokinase by monovalent cations. J Mol Biol. 2002;315:409-19 pubmed publisher
    ..The mechanism is probably general to ribokinases, to some adenosine kinases, and to other members of the larger family. A careful re-evaluation of the biochemical and structural data is suggested for other enzyme systems...
  3. Howerton S, Sines C, VanDerveer D, Williams L. Locating monovalent cations in the grooves of B-DNA. Biochemistry. 2001;40:10023-31 pubmed
    Here we demonstrate that monovalent cations can localize around B-DNA in geometrically regular, sequence-specific sites in oligonucleotide crystals...
  4. Hood M, Jacobs A, Sayood K, Dunman P, Skaar E. Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. Antimicrob Agents Chemother. 2010;54:1029-41 pubmed publisher
    ..Taken together, these data demonstrate that A. baumannii sets in motion a global regulatory cascade in response to physiological NaCl concentrations, resulting in broad-spectrum tolerance to antibiotics...
  5. Minetti G, Ciana A, Profumo A, Zappa M, Vercellati C, Zanella A, et al. Cell age-related monovalent cations content and density changes in stored human erythrocytes. Biochim Biophys Acta. 2001;1527:149-55 pubmed
    ..This may stem from a different impact of storage on the imbalance of monovalent cations, Na(+) and K(+), in young and old erythrocytes, related to their different complement of cation transporters.
  6. Ke A, Ding F, Batchelor J, Doudna J. Structural roles of monovalent cations in the HDV ribozyme. Structure. 2007;15:281-7 pubmed
    ..To investigate the role of monovalent cations in ribozyme structure and function, we determined the crystal structure of the precursor HDV ribozyme in the ..
  7. Naseem R, Holland I, Jacq A, Wann K, Campbell A. pH and monovalent cations regulate cytosolic free Ca(2+) in E. coli. Biochim Biophys Acta. 2008;1778:1415-22 pubmed publisher
    The results here show for the first time that pH and monovalent cations can regulate cytosolic free Ca(2+) in E. coli through Ca(2+) influx and efflux, monitored using aequorin. At pH 7.5 the resting cytosolic free Ca(2+) was 0.2-0...
  8. Kozak J, Kerschbaum H, Cahalan M. Distinct properties of CRAC and MIC channels in RBL cells. J Gen Physiol. 2002;120:221-35 pubmed
    ..Inwardly rectifying CRAC channels admit monovalent cations when external divalent ions are removed...
  9. Cho H, Shin J, Shin C, Lee S, Oh U. Mechanosensitive ion channels in cultured sensory neurons of neonatal rats. J Neurosci. 2002;22:1238-47 pubmed
    ..Both LT and HT MS channels were permeable to monovalent cations and Ca2+ and were blocked by gadolinium, a blocker of MS channels...

More Information

Publications62

  1. Tadros M, Gonzalez J, Rivas G, Vicente M, Mingorance J. Activation of the Escherichia coli cell division protein FtsZ by a low-affinity interaction with monovalent cations. FEBS Lett. 2006;580:4941-6 pubmed
    We have investigated the activation of FtsZ by monovalent cations. FtsZ polymerization was dependent on the concentrations of protein and monovalent salts, and was accompanied by the uptake of a single ion per monomer added...
  2. Hermosura M, Monteilh Zoller M, Scharenberg A, Penner R, Fleig A. Dissociation of the store-operated calcium current I(CRAC) and the Mg-nucleotide-regulated metal ion current MagNuM. J Physiol. 2002;539:445-58 pubmed
  3. Srinivas M, Calderon D, Kronengold J, Verselis V. Regulation of connexin hemichannels by monovalent cations. J Gen Physiol. 2006;127:67-75 pubmed
    ..connexin, exhibit a novel form of regulation characterized by extraordinary sensitivity to extracellular monovalent cations. Replacement of extracellular Na+ with K+, while maintaining extracellular Ca2+ constant, resulted in >10-..
  4. Wong A, Wu G. Selective binding of monovalent cations to the stacking G-quartet structure formed by guanosine 5'-monophosphate: a solid-state NMR study. J Am Chem Soc. 2003;125:13895-905 pubmed
    We report a solid-state multinuclear ((23)Na, (15)N, (13)C, and (31)P) NMR study on the relative affinity of monovalent cations for a stacking G-quartet structure formed by guanosine 5'-monophosphate (5'-GMP) self-association at pH 8...
  5. Gantt S, Joseph C, Fierke C. Activation and inhibition of histone deacetylase 8 by monovalent cations. J Biol Chem. 2010;285:6036-43 pubmed publisher
    ..Two bound monovalent cations (MVCs) of unknown function have been previously observed in crystal structures of HDAC8; site 1 is near the ..
  6. Di Cera E. A structural perspective on enzymes activated by monovalent cations. J Biol Chem. 2006;281:1305-8 pubmed
    Enzymes activated by monovalent cations are abundantly represented in plants and the animal world...
  7. Prakriya M, Lewis R. Separation and characterization of currents through store-operated CRAC channels and Mg2+-inhibited cation (MIC) channels. J Gen Physiol. 2002;119:487-507 pubmed
    ..physiological ionic conditions, removal of extracellular divalent cations makes them freely permeable to monovalent cations. Several past studies have concluded that under these conditions CRAC channels conduct Na(+) and Cs(+) with ..
  8. Delaunay J. The hereditary stomatocytoses: genetic disorders of the red cell membrane permeability to monovalent cations. Semin Hematol. 2004;41:165-72 pubmed
    ..hereditary stomatocytoses are mostly accounted for by genetic disorders of red cell membrane permeability to monovalent cations. These conditions, all very rare, are comprised of a hemolytic anemia, frequently macrocytosis, and the ..
  9. Mauro S, Koudelka G. Monovalent cations regulate DNA sequence recognition by 434 repressor. J Mol Biol. 2004;340:445-57 pubmed
    ..Moreover, the formation of a stable, specific repressor-OR1 complex requires the presence of monovalent cations; however, repressor-OR3 complex formation has no such requirement...
  10. Di Cera E. Thrombin: a paradigm for enzymes allosterically activated by monovalent cations. C R Biol. 2004;327:1065-76 pubmed
    Enzymes activated by monovalent cations are abundantly represented in plants and in the animal world...
  11. Stellwagen E, Dong Q, Stellwagen N. Monovalent cations affect the free solution mobility of DNA by perturbing the hydrogen-bonded structure of water. Biopolymers. 2005;78:62-8 pubmed
    ..electrophoresis in solutions of constant ionic strength containing a common anion and fifteen different monovalent cations. In solutions with the same ionic composition, the mobilities of different DNA molecules can vary by up to ..
  12. Rus A, Yokoi S, Sharkhuu A, Reddy M, Lee B, Matsumoto T, et al. AtHKT1 is a salt tolerance determinant that controls Na(+) entry into plant roots. Proc Natl Acad Sci U S A. 2001;98:14150-5 pubmed
    ..The hkt1 mutations have revealed the existence of another Na(+) influx system(s) whose activity is reduced by high [Ca(2+)](ext)...
  13. Tsueng G, Lam K. A preliminary investigation on the growth requirement for monovalent cations, divalent cations and medium ionic strength of marine actinomycete Salinispora. Appl Microbiol Biotechnol. 2010;86:1525-34 pubmed publisher
    ..29 to 15.2 mS/cm). S. arenicola has a lower growth requirement for ionic strength than S. tropica and S. pacifica...
  14. Owczarzy R, Moreira B, You Y, Behlke M, Walder J. Predicting stability of DNA duplexes in solutions containing magnesium and monovalent cations. Biochemistry. 2008;47:5336-53 pubmed publisher
    ..temperatures, transition enthalpies, entropies, and free energies in buffers containing magnesium and monovalent cations. The new correction function significantly improves the accuracy of predictions and accounts for ion ..
  15. Perrotta A, Been M. HDV ribozyme activity in monovalent cations. Biochemistry. 2006;45:11357-65 pubmed
    ..Both ribozymes self-cleaved in high concentrations of monovalent cations, and an active site cytosine was required for cleavage activity under those conditions...
  16. Orlov S, Hamet P. Apoptosis vs. oncosis: role of cell volume and intracellular monovalent cations. Adv Exp Med Biol. 2004;559:219-33 pubmed
    ..We examined this hypothesis as well as the role of monovalent cations as major intracellular osmolytes using vascular smooth muscle cells (VSMC) from the rat aorta and C7-MDCK ..
  17. Wu G, Wong A, Gan Z, Davis J. Direct detection of potassium cations bound to G-quadruplex structures by solid-state 39K NMR at 19.6 T. J Am Chem Soc. 2003;125:7182-3 pubmed
    ..Solid-state 39K NMR spectra for hydrated K salts of adenosine 2'-monophosphate and adenosine 5'-diphosphate are also reported...
  18. Gill M, Strobel S, Loria J. 205Tl NMR methods for the characterization of monovalent cation binding to nucleic acids. J Am Chem Soc. 2005;127:16723-32 pubmed
    b>Monovalent cations play an important role in many biological functions. The guanine rich sequence, d(G4T4G4), requires monovalent cations for formation of the G-quadruplex, d(G4T4G4)2...
  19. Jiang Y, Xiao M, Yin P, Zhang Y. Monovalent cations use multiple mechanisms to resolve ribozyme misfolding. RNA. 2006;12:561-6 pubmed
    Recent efforts have been made to unravel the independent roles of monovalent cations in RNA folding, primarily using the Tetrahymena ribozyme as a model. Here we report how monovalent cations impact the folding of the Candida ribozyme...
  20. de Carvalho L, Blanchard J. Kinetic analysis of the effects of monovalent cations and divalent metals on the activity of Mycobacterium tuberculosis alpha-isopropylmalate synthase. Arch Biochem Biophys. 2006;451:141-8 pubmed
    ..The features of monovalent cation and divalent metal activation, as well as the inhibition by Zn2+ and Cd2+, are discussed in light of the kinetic and structural information available for MtIPMS and other relevant enzymes...
  21. Riedel T, Schmalzing G, Markwardt F. Influence of extracellular monovalent cations on pore and gating properties of P2X7 receptor-operated single-channel currents. Biophys J. 2007;93:846-58 pubmed
    Using the patch-clamp method, we studied the influence of external alkali and organic monovalent cations on the single-channel properties of the adenosine triphosphate (ATP)-activated recombinant human P2X(7) receptor...
  22. Takamoto K, He Q, Morris S, Chance M, Brenowitz M. Monovalent cations mediate formation of native tertiary structure of the Tetrahymena thermophila ribozyme. Nat Struct Biol. 2002;9:928-33 pubmed
  23. Takamoto K, Das R, He Q, Doniach S, Brenowitz M, Herschlag D, et al. Principles of RNA compaction: insights from the equilibrium folding pathway of the P4-P6 RNA domain in monovalent cations. J Mol Biol. 2004;343:1195-206 pubmed
    ..The folding model derived from these and previous results provides a robust framework for understanding the equilibrium and kinetic folding of RNA...
  24. Shiman R, Draper D. Stabilization of RNA tertiary structure by monovalent cations. J Mol Biol. 2000;302:79-91 pubmed
    The effects of monovalent cations (Li(+), Na(+), K(+), Rb(+), Cs(+), and NH4(+)) on the thermal stability of RNA tertiary structure were investigated by UV melting...
  25. Murray J, Seyhan A, Walter N, Burke J, Scott W. The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone. Chem Biol. 1998;5:587-95 pubmed
    ..The catalytic activity of RNA enzymes is thought to require divalent metal ions, which are believed to facilitate RNA folding and to play a direct chemical role in the reaction...
  26. Wilbanks S, McKay D. Structural replacement of active site monovalent cations by the epsilon-amino group of lysine in the ATPase fragment of bovine Hsc70. Biochemistry. 1998;37:7456-62 pubmed
    ..It is possible to construct a very good structural mimic of bound cation which suffices for substrate binding but not for catalytic activity...
  27. Lopez Barneo J, Hoshi T, Heinemann S, Aldrich R. Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors Channels. 1993;1:61-71 pubmed
    ..outer mouth of the pore) produce drastic changes in C-type inactivation kinetics and in its interaction with monovalent cations. Replacement of threonine in the wild-type by glutamic acid or lysine leads to a hundred-fold acceleration ..
  28. Heginbotham L, MacKinnon R. Conduction properties of the cloned Shaker K+ channel. Biophys J. 1993;65:2089-96 pubmed
    ..6 M K+. The Shaker K+ channel is highly selective among monovalent cations; under bi-ionic conditions, its selectivity sequence is K+ > Rb+ > NH+4 > Cs+ > Na+, whereas, by ..
  29. Meissner G, Rios E, Tripathy A, Pasek D. Regulation of skeletal muscle Ca2+ release channel (ryanodine receptor) by Ca2+ and monovalent cations and anions. J Biol Chem. 1997;272:1628-38 pubmed
    ..measurements, bell-shaped Ca2+ activation/inactivation curves were obtained in media containing different monovalent cations (Li+, Na+, K+, Cs+, and choline+) and anions (Cl-, Mes-, and Pipes-)...
  30. Korotkov S, Skulskii I, Glazunov V. Cd2+ effects on respiration and swelling of rat liver mitochondria were modified by monovalent cations. J Inorg Biochem. 1998;70:17-23 pubmed
  31. Henzl M, Larson J, Agah S. Influence of monovalent cations on rat alpha- and beta-parvalbumin stabilities. Biochemistry. 2000;39:5859-67 pubmed
    ..Significantly, however, these results do not completely explain the paradoxical stability of the beta isoform, which maintains its higher melting temperature under all conditions examined...
  32. Mignen O, Shuttleworth T. Permeation of monovalent cations through the non-capacitative arachidonate-regulated Ca2+ channels in HEK293 cells. Comparison with endogenous store-operated channels. J Biol Chem. 2001;276:21365-74 pubmed
    ..However, the clear differences between the properties of these currents through ARC and SOC channels in the same cell confirm that these represent distinct conductances...
  33. Weber Ban E, Hur O, Bagwell C, Banik U, Yang L, Miles E, et al. Investigation of allosteric linkages in the regulation of tryptophan synthase: the roles of salt bridges and monovalent cations probed by site-directed mutation, optical spectroscopy, and kinetics. Biochemistry. 2001;40:3497-511 pubmed
    ..The mechanistic implications of these findings both for substrate channeling and for catalysis are discussed...
  34. Curtis E, Bartel D. The hammerhead cleavage reaction in monovalent cations. RNA. 2001;7:546-52 pubmed
    ..These results suggest that a metal ion does not act as a base in the reaction, and that the effects of different metal ions on hammerhead cleavage rates primarily reflect structural contributions to catalysis...
  35. Mubagwa K, Stengl M, Flameng W. Extracellular divalent cations block a cation non-selective conductance unrelated to calcium channels in rat cardiac muscle. J Physiol. 1997;502 ( Pt 2):235-47 pubmed
    ..6. These results suggest that a novel conductance pathway, permeable to monovalent cations but not to Cl- and blocked by divalent cations, exists in ventricular myocytes.
  36. Horvath M, Schultz S. DNA G-quartets in a 1.86 A resolution structure of an Oxytricha nova telomeric protein-DNA complex. J Mol Biol. 2001;310:367-77 pubmed
  37. Meyer M, Sühnel J. Interaction of cyclic cytosine-, guanine-, thymine-, uracil- and mixed guanine-cytosine base tetrads with K+, Na+ and Li+ ions -- a density functional study. J Biomol Struct Dyn. 2003;20:507-17 pubmed
    ..Uracil and thymine tetrads show a significant different characteristics which may contribute to the differences between DNA and RNA..
  38. Rezaei B, Meghdadi S, Majidi N. Preconcentration of thallium(III) with 2,6-bis(N-phenyl carbamoyl) pyridine on microcrystalline naphthalene prior to its trace determination in human serum spectrophotometrically. Spectrochim Acta A Mol Biomol Spectrosc. 2007;67:92-7 pubmed
    ..The precision, expressed as relative standard deviation of three measurements is better than 4.17%...
  39. Hamelberg D, Williams L, Wilson W. Influence of the dynamic positions of cations on the structure of the DNA minor groove: sequence-dependent effects. J Am Chem Soc. 2001;123:7745-55 pubmed
    ..The population of structures with no ion interactions is larger with the GGCC than with the AATT duplex, and GGCC has a wider time-average minor groove in agreement with experiment...
  40. Svoboda K, Linares A, Ribera A. Activity regulates programmed cell death of zebrafish Rohon-Beard neurons. Development. 2001;128:3511-20 pubmed
    ..The results indicate that electrical activity provides signals that are required for the normal elimination of Rohon-Beard cells...
  41. Sato Y, Suenaga K, Bandow S, Iijima S. Site-dependent migration behavior of individual cesium ions inside and outside C60 fullerene nanopeapods. Small. 2008;4:1080-3 pubmed publisher
  42. Ceresa A, Radu A, Peper S, Bakker E, Pretsch E. Rational design of potentiometric trace level ion sensors. A Ag+-selective electrode with a 100 ppt detection limit. Anal Chem. 2002;74:4027-36 pubmed
    ..With the predicted optimal composition of the inner electrolyte, its lower detection limit is found to be 10(-9) M or 100 ppt Ag+ with an ionic background of 10(-5) M LiNO3, which is very close to the expected value...
  43. Lee A, Toffaletti D, Tenor J, Soderblom E, Thompson J, Moseley M, et al. Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis. Infect Immun. 2010;78:4213-25 pubmed publisher
    ..Our findings indicate that the genes required for C. neoformans survival in CSF ex vivo are necessary for survival and infection in this unique host environment...
  44. Varma S, Rempe S. Tuning ion coordination architectures to enable selective partitioning. Biophys J. 2007;93:1093-9 pubmed
    ..Specific perturbations to the local binding site environment with respect to strongly selective K-channels result in altered K+/Na+ selectivities...
  45. Glasner M, Bergman N, Bartel D. Metal ion requirements for structure and catalysis of an RNA ligase ribozyme. Biochemistry. 2002;41:8103-12 pubmed
    ..Ligation rates of the prefolded ribozyme were directly measured and proceed at 800 min(-1) at pH 9.0...
  46. Mazzoni C, Iacchini S, Serafini A, Falcone C. Characterization of a Kluyveromyces lactis mutant with altered regulation of mitochondrial alcohol dehydrogenases. FEMS Yeast Res. 2006;6:421-7 pubmed
    ..Interestingly, the aar900 mutants had a pleiotropic phenotype and showed increased resistance to monovalent cations and benomyl, suggesting that the mutation could also affect genes other than the alcohol dehydrogenase ones...
  47. Huang S, Ryan R, Vandenberg R. The role of cation binding in determining substrate selectivity of glutamate transporters. J Biol Chem. 2009;284:4510-5 pubmed publisher
    ..This Ser/Gly residue is located between the bound substrate and one of the cation binding sites, which provides an explanation for the coupling of substrate and cation binding...
  48. Rodionova N, Petushkov V. Effect of different salts and detergents on luciferin-luciferase luminescence of the enchytraeid Fridericia heliota. J Photochem Photobiol B. 2006;83:123-8 pubmed
    ..heliota luciferase. The action of the most effective of them - Triton X-100 - is determined by its ability to reduce the actual concentration of lipid inhibitors in the reaction mixture...
  49. Bazinet L, Gendron C, Ippersiel D, René Paradis J, Tétreault C, Beaudry J, et al. Effects of type of added salt and ionic strength on physicochemical and functional properties of casein isolates produced by electroacidification. J Agric Food Chem. 2002;50:6875-81 pubmed
    ..From results on mineral concentrations, it appeared that the addition of monovalent cations did not influence the retention of monovalent or divalent cations in the BMEA isolates, while addition of ..
  50. Ourliac Garnier I, Elizondo Riojas M, Redon S, Farrell N, Bombard S. Cross-links of quadruplex structures from human telomeric DNA by dinuclear platinum complexes show the flexibility of both structures. Biochemistry. 2005;44:10620-34 pubmed
    ..Our results also suggest that the human telomere sequence could be a target for such platinum complexes...
  51. Altimimi H, Schnetkamp P. Na+-dependent inactivation of the retinal cone/brain Na+/Ca2+-K+ exchanger NCKX2. J Biol Chem. 2007;282:3720-9 pubmed
  52. Bednarczyk P, Barker G, Halestrap A. Determination of the rate of K(+) movement through potassium channels in isolated rat heart and liver mitochondria. Biochim Biophys Acta. 2008;1777:540-8 pubmed publisher
  53. Chen X, Kintner D, Baba A, Matsuda T, Shull G, Sun D. Protein aggregation in neurons following OGD: a role for Na+ and Ca2+ ionic dysregulation. J Neurochem. 2010;112:173-82 pubmed publisher
    ..We conclude that overstimulation of NKCC1 and NCX(rev) following OGD/REOX partially contributes to protein aggregation and proteasome dysfunction as a result of ionic dysregulation...