zinc sulfate

Summary

Summary: A compound given in the treatment of conditions associated with zinc deficiency such as acrodermatitis enteropathica. Externally, zinc sulfate is used as an astringent in lotions and eye drops. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)

Top Publications

  1. Tran C, Miller L, Krebs N, Lei S, Hambidge K. Zinc absorption as a function of the dose of zinc sulfate in aqueous solution. Am J Clin Nutr. 2004;80:1570-3 pubmed
    ..Zinc supplements are used extensively in medicine and research and for public health purposes in the prevention and treatment of zinc deficiency. However, little is known about the efficiency of zinc utilization after different doses...
  2. Halyard M, Jatoi A, Sloan J, Bearden J, Vora S, Atherton P, et al. Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4). Int J Radiat Oncol Biol Phys. 2007;67:1318-22 pubmed
    ..This multi-institutional, double-blind, placebo-controlled trial was conducted to provide definitive evidence of this mineral's palliative efficacy...
  3. Keast R, Breslin P. Bitterness suppression with zinc sulfate and na-cyclamate: a model of combined peripheral and central neural approaches to flavor modification. Pharm Res. 2005;22:1970-7 pubmed
    b>Zinc sulfate is known to inhibit the bitterness of the antimalarial agent quinine [R. S. J. Keast. The effect of zinc on human taste perception. J. Food Sci. 68:1871-1877 (2003)]...
  4. Uchiyama S, Ishiyama K, Hashimoto K, Yamaguchi M. Synergistic effect of beta-cryptoxanthin and zinc sulfate on the bone component in rat femoral tissues in vitro: the unique anabolic effect with zinc. Biol Pharm Bull. 2005;28:2142-5 pubmed
    The effect of the combination of beta-cryptoxanthin and zinc sulfate (zinc) on bone components in the femoral-diaphyseal and -metaphyseal tissues of young rats in vitro was investigated...
  5. Wallenborn J, Evansky P, Shannahan J, Vallanat B, Ledbetter A, Schladweiler M, et al. Subchronic inhalation of zinc sulfate induces cardiac changes in healthy rats. Toxicol Appl Pharmacol. 2008;232:69-77 pubmed publisher
    ..weeks age) were exposed via nose only inhalation to filtered air or 10, 30 or 100 microg/m(3) of aerosolized zinc sulfate (ZnSO(4)), 5 h/day, 3 days/week for 16 weeks...
  6. Al Maroof R, Al Sharbatti S. Serum zinc levels in diabetic patients and effect of zinc supplementation on glycemic control of type 2 diabetics. Saudi Med J. 2006;27:344-50 pubmed
  7. Sharquie K, Najim R, Al Dori W, Al Hayani R. Oral zinc sulfate in the treatment of Behcet's disease: a double blind cross-over study. J Dermatol. 2006;33:541-6 pubmed
    This was a randomized, controlled, double-blind trial of zinc sulfate in the treatment of Behcet's disease. Patients with Behcet's disease were recruited in this study between November 2001 and February 2003...
  8. Ghasemi N, Babaei H, Azizallahi S, Kheradmand A. Effect of long-term administration of zinc after scrotal heating on mice spermatozoa and subsequent offspring quality. Andrologia. 2009;41:222-8 pubmed publisher
    ..Likewise, long-term administration of zinc could improve quality of litter obtained from the females mated with scrotal heat treatment males...
  9. Hotz C, DeHaene J, Woodhouse L, Villalpando S, Rivera J, King J. Zinc absorption from zinc oxide, zinc sulfate, zinc oxide + EDTA, or sodium-zinc EDTA does not differ when added as fortificants to maize tortillas. J Nutr. 2005;135:1102-5 pubmed
    ..compare fractional zinc absorption from a test meal that included a maize tortilla fortified with zinc oxide, zinc sulfate, zinc oxide + EDTA, or sodium-zinc EDTA...

More Information

Publications62

  1. Ebisch I, Pierik F, de Jong F, Thomas C, Steegers Theunissen R. Does folic acid and zinc sulphate intervention affect endocrine parameters and sperm characteristics in men?. Int J Androl. 2006;29:339-45 pubmed
    ..Although zinc and folate have several effects on spermatogenesis, the underlying mechanisms involved are not clear...
  2. Solomons N, Romero Abal M, Weiss G, Michalke B, Schumann K. Bioavailability of zinc from NutriSet zinc tablets compared with aqueous zinc sulfate. Eur J Clin Nutr. 2011;65:125-31 pubmed publisher
    ..In this study we aimed to compare the relative bioavailability of oral doses of 30 mg of Zn in two dosing forms...
  3. Keller M, Douhard Q, Baum M, Bakker J. Sexual experience does not compensate for the disruptive effects of zinc sulfate--lesioning of the main olfactory epithelium on sexual behavior in male mice. Chem Senses. 2006;31:753-62 pubmed
    ..Male mice, which were either sexually naive or experienced, received an intranasal irrigation of either a zinc sulfate solution to destroy the MOE or saline...
  4. Wei Y, Shohag M, Wang Y, Lu L, Wu C, Yang X. Effect of zinc sulfate fortification in germinated brown rice on seed zinc concentration, bioavailability, and seed germination. J Agric Food Chem. 2012;60:1871-9 pubmed publisher
  5. Sharquie K, Al Mashhadani S, Salman H. Topical 10% zinc sulfate solution for treatment of melasma. Dermatol Surg. 2008;34:1346-9 pubmed publisher
    Multiple modalities have been used in the treatment of melasma, such as bleaching agents, chemical peels, and antioxidants. Topical zinc sulfate has peeling and antioxidant effects.
  6. Uchiyama S, Yamaguchi M. Anabolic effect of beta-cryptoxanthin in osteoblastic MC3T3-E1 cells is enhanced with 17beta-estradiol, genistein, or zinc sulfate in vitro: the unique effect with zinc on Runx2 and alpha1(I) collagen mRNA expressions. Mol Cell Biochem. 2008;307:209-19 pubmed
    ..Culture with zinc sulfate (zinc; 10(-5) M) caused a significant increase in protein content or alkaline phosphatase activity in ..
  7. McBride K, Slotnick B, Margolis F. Does intranasal application of zinc sulfate produce anosmia in the mouse? An olfactometric and anatomical study. Chem Senses. 2003;28:659-70 pubmed
    ..and discrimination tasks after irrigation of their olfactory epithelium in each naris with 50 microl of 5% zinc sulfate or saline...
  8. Wong W, Merkus H, Thomas C, Menkveld R, Zielhuis G, Steegers Theunissen R. Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial. Fertil Steril. 2002;77:491-8 pubmed
    To study the effects of folic acid and zinc sulfate treatment on semen variables in fertile and subfertile men.
  9. Surjawidjaja J, Hidayat A, Lesmana M. Growth inhibition of enteric pathogens by zinc sulfate: an in vitro study. Med Princ Pract. 2004;13:286-9 pubmed
    To determine the inhibition effect of zinc sulfate on isolates of enteric bacteria.
  10. Firooz A, Khatami A, Khamesipour A, Nassiri Kashani M, Behnia F, Nilforoushzadeh M, et al. Intralesional injection of 2% zinc sulfate solution in the treatment of acute old world cutaneous leishmaniasis: a randomized, double-blind, controlled clinical trial. J Drugs Dermatol. 2005;4:73-9 pubmed
    Several in vitro and in vivo studies have shown inhibitory effects of zinc sulfate (ZnSO4) on Leishmania parasites...
  11. Schott Ohly P, Lgssiar A, Partke H, Hassan M, Friesen N, Gleichmann H. Prevention of spontaneous and experimentally induced diabetes in mice with zinc sulfate-enriched drinking water is associated with activation and reduction of NF-kappa B and AP-1 in islets, respectively. Exp Biol Med (Maywood). 2004;229:1177-85 pubmed
    Recently, we reported that zinc sulfate-enriched (25 mM) drinking water (Zn(2+)) protected male C57BL/6 mice from diabetes induced by multiple low doses of streptozotocin (MLD-STZ) and that MLD-STZ activates the transcription factors ..
  12. Keast R, Canty T, Breslin P. Oral zinc sulfate solutions inhibit sweet taste perception. Chem Senses. 2004;29:513-21 pubmed
    We investigated the ability of zinc sulfate (5, 25, 50 mM) to inhibit the sweetness of 12 chemically diverse sweeteners, which were all intensity matched to 300 mM sucrose [800 mM glucose, 475 mM fructose, 3.25 mM aspartame, 3...
  13. Iraji F, Vali A, Asilian A, Shahtalebi M, Momeni A. Comparison of intralesionally injected zinc sulfate with meglumine antimoniate in the treatment of acute cutaneous leishmaniasis. Dermatology. 2004;209:46-9 pubmed
    ..High cost, side effects, multiple injections and incomplete efficacy are limitations of this therapy. Zinc sulfate (ZS) has been reported to be effective in the treatment of cutaneous leishmaniasis.
  14. Williams S, Gilbey T, Barnett S. Immunohistochemical studies of the cellular changes in the peripheral olfactory system after zinc sulfate nasal irrigation. Neurochem Res. 2004;29:891-901 pubmed
    ..We have performed an immunohistochemical study of the cellular changes that occur after zinc sulfate irrigation of the nasal cavity...
  15. Akhondzadeh S, Mohammadi M, Khademi M. Zinc sulfate as an adjunct to methylphenidate for the treatment of attention deficit hyperactivity disorder in children: a double blind and randomized trial [ISRCTN64132371]. BMC Psychiatry. 2004;4:9 pubmed
    ..To the best of our knowledge, this study is the first double blind and placebo controlled clinical trial assessing the adjunctive role of zinc in ADHD...
  16. Ertekin M, Koc M, Karslioglu I, Sezen O. Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study. Int J Radiat Oncol Biol Phys. 2004;58:167-74 pubmed
    ..To determine the effect of oral zinc sulphate supplementation on radiation-induced oropharyngeal mucositis in patients with head-and-neck cancer...
  17. Bilici M, Yildirim F, Kandil S, Bekaroğlu M, Yildirmis S, Deger O, et al. Double-blind, placebo-controlled study of zinc sulfate in the treatment of attention deficit hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28:181-90 pubmed
    ..Some studies suggest that deficiency of zinc play a substantial role in the aetiopathogenesis of ADHD. Therefore, to assess the efficacy of zinc sulfate we conducted treatment trial.
  18. Herman S, Griffin I, Suwarti S, Ernawati F, Permaesih D, Pambudi D, et al. Cofortification of iron-fortified flour with zinc sulfate, but not zinc oxide, decreases iron absorption in Indonesian children. Am J Clin Nutr. 2002;76:813-7 pubmed
    ..However, little is known about the effect of zinc fortification of flour on iron bioavailability or about the optimum form of zinc supplementation...
  19. Ducray A, Bondier J, Michel G, Bon K, Millot J, Propper A, et al. Recovery following peripheral destruction of olfactory neurons in young and adult mice. Eur J Neurosci. 2002;15:1907-17 pubmed
    ..This was achieved more rapidly than total ON regeneration, suggesting that a reduced number of reconnected ON may be sufficient for odor discrimination...
  20. Luk H, Ko J, Fung H, Cho C. Delineation of the protective action of zinc sulfate on ulcerative colitis in rats. Eur J Pharmacol. 2002;443:197-204 pubmed
    ..A similar action of zinc sulfate on ulcerative colitis has not been defined...
  21. Zajac A, Johnson J, King S. Evaluation of the importance of centrifugation as a component of zinc sulfate fecal flotation examinations. J Am Anim Hosp Assoc. 2002;38:221-4 pubmed
    Fifty canine fecal samples were evaluated by five flotation procedures to compare the sensitivity of the zinc sulfate (ZnSO4) centrifugation flotation test with ZnSO4 flotation tests using benchtop incubation during the flotation period...
  22. Slotnick B, Glover P, Bodyak N. Does intranasal application of zinc sulfate produce anosmia in the rat?. Behav Neurosci. 2000;114:814-29 pubmed
    ..1-0.5 ml 5% zinc sulfate. After treatment, rats showed few or no deficits in discriminating among odors and in detecting high (1%-0...
  23. Banu B, Devi K, Mahboob M, Jamil K. In vivo genotoxic effect of zinc sulfate in mouse peripheral blood leukocytes using Comet assay. Drug Chem Toxicol. 2001;24:63-73 pubmed
    Single stranded DNA breaks induced by Zinc sulfate in mice has been studied in vivo using Alkaline Single Cell Gel Electrophoresis (Comet assay). Mice were administered orally with doses of 5.70, 8.55, 11.40, 14.25, 17.10 and 19...
  24. Ebisch I, van Heerde W, Thomas C, van der Put N, Wong W, Steegers Theunissen R. C677T methylenetetrahydrofolate reductase polymorphism interferes with the effects of folic acid and zinc sulfate on sperm concentration. Fertil Steril. 2003;80:1190-4 pubmed
    To determine the frequency of C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism in fertile and subfertile males, and the MTHFR-dependent response of sperm concentration after folic acid and/or zinc sulfate intervention.
  25. Williams S, Franklin R, Barnett S. Response of olfactory ensheathing cells to the degeneration and regeneration of the peripheral olfactory system and the involvement of the neuregulins. J Comp Neurol. 2004;470:50-62 pubmed
    ..the proliferative response of olfactory ensheathing cells (OECs) to olfactory receptor neuron injury induced by zinc sulfate (ZnSO4) irrigation and related the response of OECs within the peripheral system to the inflammatory response ..
  26. Hosseinpour M, Fazeli A, Agabeigi M. Efficacy of Acacia senegal for stoma care in children with colostomy. Eur J Pediatr Surg. 2012;22:234-7 pubmed publisher
    ..In this study, we introduce a novel protection with Acacia senegal and compare the protective effects of this barrier with zinc sulfate ointment.
  27. Wada I, Otaka M, Jin M, Odashima M, Komatsu K, Konishi N, et al. Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection. Biochem Biophys Res Commun. 2006;349:611-8 pubmed
    ..Also, the association of gastric mucosal protective function against HCl-challenge was compared between HSP72-induced and -reduced group...
  28. Suemori S, Shimazawa M, Kawase K, Satoh M, Nagase H, Yamamoto T, et al. Metallothionein, an endogenous antioxidant, protects against retinal neuron damage in mice. Invest Ophthalmol Vis Sci. 2006;47:3975-82 pubmed
    ..MT) in retinal damage in mice deficient in both MT-I and -II (MT-I/-II-deficient mice [C57BL/6J background]) and wild-type (C57BL/6J) mice and MT induction (zinc sulfate [ZnSO4] and 1alpha, 25-dihydroxyvitamin D3 [Vit. D3]).
  29. Girlich D, Poirel L, Nordmann P. Value of the modified Hodge test for detection of emerging carbapenemases in Enterobacteriaceae. J Clin Microbiol. 2012;50:477-9 pubmed publisher
    ..Its sensitivity is low for NDM-1 producers (50%) but is increased to 85.7% by adding ZnSO(4) (100 ?g/ml) in the culture medium. However, this test has a low specificity and is time-consuming...
  30. Hovan A, Williams P, Stevenson Moore P, Wahlin Y, Ohrn K, Elting L, et al. A systematic review of dysgeusia induced by cancer therapies. Support Care Cancer. 2010;18:1081-7 pubmed publisher
    ..The purpose was to review relevant scientific papers written since 1989 which focused on the prevalence and management of dysgeusia as an oral side effect of cancer treatment...
  31. Puhal Raj A, Ramachandra Raja C. Studies on the synthesis, spectral, optical and thermal properties of l-Valine Zinc Sulphate: an organic inorganic hybrid nonlinear optical crystal. Spectrochim Acta A Mol Biomol Spectrosc. 2012;97:83-7 pubmed publisher
    ..Kurtz powder second harmonic generation (SHG) test confirms NLO property of the crystal and SHG efficiency of LVZS was found to be 1.34 times more than pure l-valine...
  32. Dortet L, Poirel L, Nordmann P. Rapid identification of carbapenemase types in Enterobacteriaceae and Pseudomonas spp. by using a biochemical test. Antimicrob Agents Chemother. 2012;56:6437-40 pubmed publisher
    ..This is an easy and reliable technique (100% sensitivity and specificity) for detection of not only carbapenemase activity but also carbapenemase types in Enterobacteriaceae and Pseudomonas aeruginosa...
  33. Wessells K, Ouédraogo Z, Rouamba N, Hess S, Ouedraogo J, Brown K. Short-term zinc supplementation with dispersible tablets or zinc sulfate solution yields similar positive effects on plasma zinc concentration of young children in Burkina Faso: a randomized controlled trial. J Pediatr. 2012;160:129-35.e3 pubmed publisher
  34. Ganguly A, Chakraborty S, Datta K, Hazra A, Datta S, Chakraborty J. A randomized controlled trial of oral zinc in acute pneumonia in children aged between 2 months to 5 years. Indian J Pediatr. 2011;78:1085-90 pubmed publisher
    ..To evaluate the effectiveness and safety of zinc supplementation as adjuvant in treatment of pneumonia...
  35. Farvid M, Homayouni F, Amiri Z, Adelmanesh F. Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation. Diabetes Res Clin Pract. 2011;93:86-94 pubmed publisher
    ..The aim of the present study was to determine if micronutrients supplementation can improve neuropathy indices in type 2 diabetes...
  36. Farthing M, Salam M, Lindberg G, Dite P, Khalif I, Salazar Lindo E, et al. Acute diarrhea in adults and children: a global perspective. J Clin Gastroenterol. 2013;47:12-20 pubmed publisher
  37. Schlegel P, Windisch W. Bioavailability of zinc glycinate in comparison with zinc sulphate in the presence of dietary phytate in an animal model with Zn labelled rats. J Anim Physiol Anim Nutr (Berl). 2006;90:216-22 pubmed
    ..Overall, the bioavailability of zinc glycinate was significantly superior by 16% to zinc sulphate (49% vs. 42%), mainly because of a higher absorptive potential at presence of a strong anti-nutritive component (phytate) in the diet...
  38. Sagardoy R, Morales F, López Millán A, Abadia A, Abadía J. Effects of zinc toxicity on sugar beet (Beta vulgaris L.) plants grown in hydroponics. Plant Biol (Stuttg). 2009;11:339-50 pubmed publisher
    ..These data indicate that sugar beet could be a good model to investigate Zn homeostasis mechanisms in plants, but is not an efficient species for Zn phytoremediation...
  39. Stefani M, Bottino G, Fontenelle E, Azulay D. [Efficacy comparison between cimetidine and zinc sulphate in the treatment of multiple and recalcitrant warts]. An Bras Dermatol. 2009;84:23-9 pubmed
    ..Cimetidine and zinc sulphate have important effects on the immune system and are used as immunomodulators in the treatment of various diseases...
  40. El Khattabi A, Seddik H, Fatihi J, Salaheddine H, Badaoui M, Amezyane T, et al. [Acute recurrent hemolytic anemia as the first manifestation of Wilson's disease: Report of a case]. Transfus Clin Biol. 2009;16:39-42 pubmed publisher
    ..The liver and central nervous system are the usual targets of Wilson's disease, an inherited disorder of copper metabolism. Severe hemolytic anemia is an unusual complication of Wilson's disease...
  41. Sharquie K, Khorsheed A, Al Nuaimy A. Topical zinc sulphate solution for treatment of viral warts. Saudi Med J. 2007;28:1418-21 pubmed
    ..To assess the efficacy and safety of topical zinc sulphate solution in the treatment of plane and common warts...
  42. Shukla S, Sharma Y, Shrivastava S. Reversal of Lead-Induced Acute Toxicity by Lipoic Acid with Nutritional Supplements in Male Wistar Rats. J Environ Pathol Toxicol Oncol. 2016;35:171-83 pubmed publisher
  43. Afanasieva O, Suslov N, Shilova I. Antidepressant, psychostimulant, and nootropic effects of major and trace element composition. Bull Exp Biol Med. 2013;155:204-6 pubmed
    ..and nootropic effects of a composition of major and trace elements including KCl, RbNO3, magnesium sulfate, and zinc sulfate were studied on the models of behavioural despair (Porsolt test) and conditioned passive avoidance test...
  44. Yoshioka H, Usuda H, Fukuishi N, Nonogaki T, Onosaka S. Carbon Tetrachloride-Induced Nephrotoxicity in Mice Is Prevented by Pretreatment with Zinc Sulfate. Biol Pharm Bull. 2016;39:1042-6 pubmed publisher
    ..These findings suggest that prophylaxis with Zn protects mice from CCl4-induced acute nephrotoxicity, presumably by induction of MT, which in turn scavenges radicals induced by CCl4 exposure. ..
  45. Arbabi Kalati F, Arbabi kalati F, Deghatipour M, Ansari Moghadam A. Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: a double-blind randomized clinical trial. Arch Iran Med. 2012;15:413-7 pubmed publisher
    ..There is no cure for mucositis. Some studies have evaluated the effect of zinc sulfate on mucositis...
  46. Mahajan S, Law W, Aalinkeel R, Reynolds J, Nair B, Yong K, et al. Nanoparticle-mediated targeted delivery of antiretrovirals to the brain. Methods Enzymol. 2012;509:41-60 pubmed publisher
    ..We describe methods for synthesis of the Tf-QD-Amprenavir nanoplex and approaches to evaluate both its BBB transversing capability and antiviral efficacy...
  47. Bzik V, Medani M, Baird A, Winter D, Brayden D. Mechanisms of action of zinc on rat intestinal epithelial electrogenic ion secretion: insights into its antidiarrhoeal actions. J Pharm Pharmacol. 2012;64:644-53 pubmed publisher
    ..Zinc is a useful addition to oral rehydration therapy for acute diarrhoea. We have assessed the mechanism of its epithelial antisecretory action when intestinal epithelial tight junctions were pharmacologically opened...
  48. Liang G, Li L, Liu H, Zhang J, Burda C, Zhu J. Fabrication of near-infrared-emitting CdSeTe/ZnS core/shell quantum dots and their electrogenerated chemiluminescence. Chem Commun (Camb). 2010;46:2974-6 pubmed publisher
    ..New water-soluble CdSeTe/ZnS core-shell quantum dots with excellent near-infrared emission were synthesized via an aqueous solution method; they showed strong electrogenerated chemiluminescence and favorable biocompatibility...
  49. Windfuhr J, Cao Van H, Landis B. Recovery from long-lasting post-tonsillectomy dysgeusia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:e11-4 pubmed publisher
    ..report a case of a female patient who reported a 4-year PTD and recovered within 2 months after oral intake of zinc sulfate. This clinical observation, together with recent findings on significant improvement of taste disorders after ..
  50. Russell S, Siren P, Siren M, Tisdale M. Mechanism of attenuation of protein loss in murine C2C12 myotubes by D-myo-inositol 1,2,6-triphosphate. Exp Cell Res. 2010;316:286-95 pubmed publisher
    ..The ability of AT to attenuate muscle atrophy by a range of stimuli suggests that it may be effective in several catabolic conditions...
  51. Tournier B, Frelon S, Tourlonias E, Agez L, Delissen O, Dublineau I, et al. Role of the olfactory receptor neurons in the direct transport of inhaled uranium to the rat brain. Toxicol Lett. 2009;190:66-73 pubmed publisher
    ..These results give prominence to a role of the ORN in the direct transfer of the uranium from the nasal cavity to the brain...
  52. Yovanovich C, Jungblut L, Heer T, Pozzi A, Paz D. Amphibian larvae and zinc sulphate: a suitable model to study the role of brain-derived neurotrophic factor (BDNF) in the neuronal turnover of the olfactory epithelium. Cell Tissue Res. 2009;336:1-9 pubmed publisher
    ..Our results thus suggest that BDNF is involved in the regeneration of the OE of amphibian larvae, and that our approach is suitable for further investigations of this topic...
  53. Kuhn J, Bewermeyer H, Miyajima H, Takahashi Y, Kuhn K, Hoogenraad T. Treatment of symptomatic heterozygous aceruloplasminemia with oral zinc sulphate. Brain Dev. 2007;29:450-3 pubmed
    ..The present report concerns the beneficial treatment of an 18-year-old girl with extrapyramidal and cerebellar-mediated movement disorder caused by a heterozygous mutation of the ceruloplasmin gene using oral zinc sulphate...