thiosulfates

Summary

Summary: Inorganic salts of thiosulfuric acid possessing the general formula R2S2O3.

Top Publications

  1. Hall A, Dart R, Bogdan G. Sodium thiosulfate or hydroxocobalamin for the empiric treatment of cyanide poisoning?. Ann Emerg Med. 2007;49:806-13 pubmed
    ..Hydroxocobalamin is being developed for potential introduction in the United States and may represent a new option for emergency personnel in cases of suspected or confirmed cyanide poisoning in the out-of-hospital setting...
  2. Hensen D, Sperling D, Trüper H, Brune D, Dahl C. Thiosulphate oxidation in the phototrophic sulphur bacterium Allochromatium vinosum. Mol Microbiol. 2006;62:794-810 pubmed
    ..vinosum appears to be related to the lack of soxCD genes, the products of which are proposed to oxidize SoxY-bound sulphane sulphur. In their absence the latter is instead transferred to growing sulphur globules...
  3. Lagrange C, Lele S, Pais V. The effect of sodium thiosulfate administration on nephrocalcinosis in a rat model. J Endourol. 2009;23:529-33 pubmed publisher
    ..We proposed a rat model to evaluate whether STS has any possible beneficial effect on calcium nephrolithiasis or nephrocalcinosis...
  4. Fairbrother L, Etschmann B, Brugger J, Shapter J, Southam G, Reith F. Biomineralization of gold in biofilms of Cupriavidus metallidurans. Environ Sci Technol. 2013;47:2628-35 pubmed publisher
    ..This study demonstrates the importance of C. metallidurans biofilms for the detoxification of Au-complexes and demonstrates a central role for bacterial biomineralization in the formation of highly pure Au in surface environments...
  5. Bradley A, Leavitt W, Johnston D. Revisiting the dissimilatory sulfate reduction pathway. Geobiology. 2011;9:446-57 pubmed publisher
    ..the rate of sulfite delivery to the active site of Dsr. This reaction network may help geochemists to better understand the relationship between the physiology of sulfate reduction and the isotopic record it produces...
  6. Dahl C, Engels S, Pott Sperling A, Schulte A, Sander J, Lübbe Y, et al. Novel genes of the dsr gene cluster and evidence for close interaction of Dsr proteins during sulfur oxidation in the phototrophic sulfur bacterium Allochromatium vinosum. J Bacteriol. 2005;187:1392-404 pubmed
  7. Hackett B, McAleer M, Sheehan G, Powell F, O Donnell B. Calciphylaxis in a patient with normal renal function: response to treatment with sodium thiosulfate. Clin Exp Dermatol. 2009;34:39-42 pubmed publisher
    ..To our knowledge, this is the first reported case of the use of sodium thiosulfate to treat calciphylaxis in a patient with normal renal function...
  8. Asplin J, Donahue S, Lindeman C, Michalenka A, Strutz K, Bushinsky D. Thiosulfate reduces calcium phosphate nephrolithiasis. J Am Soc Nephrol. 2009;20:1246-53 pubmed publisher
    ..In summary, sodium thiosulfate reduces calcium phosphate stone formation in the genetic hypercalciuric rat. Controlled trials testing the efficacy and safety of sodium thiosulfate for recurrent kidney stones in humans are needed...
  9. Brucculeri M, Cheigh J, Bauer G, Serur D. Long-term intravenous sodium thiosulfate in the treatment of a patient with calciphylaxis. Semin Dial. 2005;18:431-4 pubmed
    ..However, given the lack of significant toxicity, as well as a dramatic clinical improvement, we feel that sodium thiosulfate may have an important adjunctive role in the treatment of calciphylaxis in dialysis patients...

More Information

Publications62

  1. Chang H, Yamato O, Yamasaki M, Ko M, Maede Y. Growth inhibitory effect of alk(en)yl thiosulfates derived from onion and garlic in human immortalized and tumor cell lines. Cancer Lett. 2005;223:47-55 pubmed
    Two alk(en)yl thiosulfates, sodium n-propyl thiosulfate (NPTS) and sodium 2-propenyl thiosulfate (2PTS), are natural constituents of onion and garlic, respectively, which were identified originally as causative agents of onion- and garlic-..
  2. Chang H, Ko M, Ishizuka M, Fujita S, Yabuki A, Hossain M, et al. Sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxification enzymes in rat hepatoma H4IIE cells. Nutr Res. 2010;30:435-40 pubmed publisher
    ..Here, we hypothesized that alk(en)yl thiosulfates, sodium n-propyl thiosulfate (NPTS), and sodium 2-propenyl thiosulfate (2PTS), which were identified in onions ..
  3. Wagstaff C, Chanasut U, Harren F, Laarhoven L, Thomas B, Rogers H, et al. Ethylene and flower longevity in Alstroemeria: relationship between tepal senescence, abscission and ethylene biosynthesis. J Exp Bot. 2005;56:1007-16 pubmed
  4. Cicone J, Petronis J, Embert C, Spector D. Successful treatment of calciphylaxis with intravenous sodium thiosulfate. Am J Kidney Dis. 2004;43:1104-8 pubmed
    ..Prolonged treatment was well tolerated without serious side effects and accompanied by continued clinical improvement...
  5. Adirekkiat S, Sumethkul V, Ingsathit A, Domrongkitchaiporn S, Phakdeekitcharoen B, Kantachuvesiri S, et al. Sodium thiosulfate delays the progression of coronary artery calcification in haemodialysis patients. Nephrol Dial Transplant. 2010;25:1923-9 pubmed publisher
    ..The effect of sodium thiosulfate on CAC in haemodialysis patients has never been studied...
  6. Pasch A, Schaffner T, Huynh Do U, Frey B, Frey F, Farese S. Sodium thiosulfate prevents vascular calcifications in uremic rats. Kidney Int. 2008;74:1444-53 pubmed publisher
    ..The negative impact on rat bone integrity necessitates a careful risk-benefit analysis before sodium thiosulfate can be used in individual human patients...
  7. Frederiksen T, Finster K. Sulfite-oxido-reductase is involved in the oxidation of sulfite in Desulfocapsa sulfoexigens during disproportionation of thiosulfate and elemental sulfur. Biodegradation. 2003;14:189-98 pubmed
    ..CCCP totally inhibited sulfur disproportionation and reduced thiosulfate disproportionation by 80% compared to an unamended control. HQNO reduced thiosulfate disproportionation by 80% and sulfur disproportionation by 90%...
  8. Burgos L, Alburquerque N. Ethylene inhibitors and low kanamycin concentrations improve adventitious regeneration from apricot leaves. Plant Cell Rep. 2003;21:1167-74 pubmed
    ..6 and 17.1 micro M). With this improved procedure, regeneration from apricot leaves has been increased more than 200% as compared with rates reported previously...
  9. Furne J, Springfield J, Koenig T, DeMaster E, Levitt M. Oxidation of hydrogen sulfide and methanethiol to thiosulfate by rat tissues: a specialized function of the colonic mucosa. Biochem Pharmacol. 2001;62:255-9 pubmed
    ..Defects in this detoxification pathway possibly could play a role in the pathogenesis of various forms of colitis...
  10. Pott A, Dahl C. Sirohaem sulfite reductase and other proteins encoded by genes at the dsr locus of Chromatium vinosum are involved in the oxidation of intracellular sulfur. Microbiology. 1998;144 ( Pt 7):1881-94 pubmed
    ..vinosum are located in the extracytoplasmic space whilst the dsr gene products appear to be either cytoplasmic or membrane-bound led to the proposal of new models for the pathway of sulfur oxidation in this phototrophic sulfur bacterium...
  11. Yamato O, Hayashi M, Yamasaki M, Maede Y. Induction of onion-induced haemolytic anaemia in dogs with sodium n-propylthiosulphate. Vet Rec. 1998;142:216-9 pubmed
    ..In the affected dogs there was a 10-fold increase in the concentration of oxidised glutathione in their erythrocytes 12 hours after the administration of the compound, whereas in normal dogs there was almost no change...
  12. Prange A, Chauvistré R, Modrow H, Hormes J, Trüper H, Dahl C. Quantitative speciation of sulfur in bacterial sulfur globules: X-ray absorption spectroscopy reveals at least three different species of sulfur. Microbiology. 2002;148:267-76 pubmed
    ..These results indicate that the speciation of sulfur in the sulfur globules reflects the different ecological and physiological properties of different metabolic groups of bacteria...
  13. Mikami I, Shibayama E, Yuzawa M, Miura Y. Effect of ethanol addition on the determination of thiosulfate based on reduction of Ce(IV) and fluorescence detection of Ce(III). Anal Sci. 2012;28:979-83 pubmed
    ..The detection limits as S/N = 3 for thiosulfate were very low (10(-9) M level)...
  14. Gharib M, Marcantonio M, Lehmann S, Courcelles M, Meloche S, Verreault A, et al. Artifactual sulfation of silver-stained proteins: implications for the assignment of phosphorylation and sulfation sites. Mol Cell Proteomics. 2009;8:506-18 pubmed publisher
    ..02%, which is typically used for silver staining. The significance of this artifact is discussed in the broader context of sulfation and phosphorylation site identification from in vivo and in vitro experiments...
  15. Pagnini I, Simonini G, Giani T, Marrani E, Moretti D, Vannucci G, et al. Sodium thiosulfate for the treatment of calcinosis secondary to juvenile dermatomyositis. Clin Exp Rheumatol. 2014;32:408-9 pubmed
    ..This therapy may have a role in improving calcinosis, even if more studies are necessary to determine the safety and efficacy of this treatment in juvenile dermatomyositis-related calcinosis. ..
  16. Bedner M, MacCrehan W, Helz G. Making chlorine greener: investigation of alternatives to sulfite for dechlorination. Water Res. 2004;38:2505-14 pubmed
    ..Metallic iron is shown to reduce inorganic and organic chloramines effectively. The implications of these results for wastewater chlorine reduction and analysis are discussed...
  17. Hoque E, Pflugmacher S, Fritscher J, Wolf M. Induction of glutathione S-transferase in biofilms and germinating spores of Mucor hiemalis strain EH5 from cold sulfidic spring waters. Appl Environ Microbiol. 2007;73:2697-707 pubmed
    ..Our results may contribute to our understanding of induction of GST by sulfurous compounds, as well as to the immunofluorescence visualization of GST in aquatic fungus and fungus-bacterium biofilms...
  18. McLaughlin M, Balaa M. Enhanced contrast of bacteriophage plaques in Salmonella with ferric ammonium citrate and sodium thiosulfate (FACST) and tetrazolium red (TZR). J Microbiol Methods. 2006;65:318-23 pubmed
    ..At the concentrations tested, neither reagent affected plaque counts in the H2S+ strain. The FACST should be useful in bacteriophage plaque assays with H2S+ strains of Salmonella and other H2S+ bacteria...
  19. Inagaki F, Takai K, Nealson K, Horikoshi K. Sulfurovum lithotrophicum gen. nov., sp. nov., a novel sulfur-oxidizing chemolithoautotroph within the epsilon-Proteobacteria isolated from Okinawa Trough hydrothermal sediments. Int J Syst Evol Microbiol. 2004;54:1477-82 pubmed
    ..On the basis of the physiological and molecular characteristics of this isolate, the type species of a novel genus, Sulfurovum lithotrophicum gen. nov., sp. nov., is proposed. The type strain is 42BKTT (= ATCC BAA-797T = JCM 12117T)...
  20. Dethloff S. Calcific uremic arteriolopathy: treatment with intraperitoneal sodium thiosulfate in a patient on peritoneal dialysis. Nephrol Nurs J. 2012;39:323-5, 347 pubmed
    ..Registries such as this provide a valuable database that may one day lead to improved approaches in the treatment of this uncommon, debilitating, and often fatal disease...
  21. Zitt E, König M, Vychytil A, Auinger M, Wallner M, Lingenhel G, et al. Use of sodium thiosulphate in a multi-interventional setting for the treatment of calciphylaxis in dialysis patients. Nephrol Dial Transplant. 2013;28:1232-40 pubmed publisher
    ..The aim of the present study was to determine the therapeutic response to a multi-interventional treatment regimen with consistent use of sodium thiosulphate (STS) in an Austrian cohort of calciphylaxis patients...
  22. Hayden M, Goldsmith D, Sowers J, Khanna R. Calciphylaxis: calcific uremic arteriolopathy and the emerging role of sodium thiosulfate. Int Urol Nephrol. 2008;40:443-51 pubmed publisher
    ..Indeed, as with any new treatment this emerging therapy should be studied in greater detail, but this old drug seems to have a new life in the hands of treating physicians...
  23. McDonald J, Gao S, Qin R, Trout T, Hanson B. Thiosulfate and manure amendment with water application and tarp on 1,3-dichloropropene emission reductions. Environ Sci Technol. 2008;42:398-402 pubmed
    ..Amendment of surface soil with organic materials shows greater potential in minimizing fumigant emissions than with chemicals with the need for a better understanding of the organic-fumigant reaction mechanism...
  24. Perciani C, Peixoto P, Dias W, Kubrusly F, Tanizaki M. Improved method to calculate the antibody avidity index. J Clin Lab Anal. 2007;21:201-6 pubmed
    ..The new method for AI calculation presented here takes into account the whole data of the ELISA titration curve in which the final numerical AI is the average of each point...
  25. Theissen U, Martin W. Sulfide : quinone oxidoreductase (SQR) from the lugworm Arenicola marina shows cyanide- and thioredoxin-dependent activity. FEBS J. 2008;275:1131-9 pubmed publisher
    ..None of the mutant enzymes was active after expression in yeast, implicating these amino acids in the catalytic mechanism of the eukaryotic enzyme...
  26. Gianinetti A, Laarhoven L, Persijn S, Harren F, Petruzzelli L. Ethylene production is associated with germination but not seed dormancy in red rice. Ann Bot. 2007;99:735-45 pubmed
    ..The relationship between ethylene production and both seed dormancy and germination was investigated using red rice (weedy rice) as a model species...
  27. Slobodkina G, Panteleeva A, Kostrikina N, Kopitsyn D, Bonch Osmolovskaya E, Slobodkin A. Tepidibacillus fermentans gen. nov., sp. nov.: a moderately thermophilic anaerobic and microaerophilic bacterium from an underground gas storage. Extremophiles. 2013;17:833-9 pubmed publisher
    ..We propose to assign strain STGH(T) to a new species of a novel genus Tepidibacillus fermentans gen. nov., sp.nov. The type strain is STGH(T) (=DSM 23802(T), =VKM B-2671(T))...
  28. Kappler U, Maher M. The bacterial SoxAX cytochromes. Cell Mol Life Sci. 2013;70:977-92 pubmed publisher
  29. Jin P, Xia L, Li Z, Che N, Zou D, Hu X. Rapid determination of thiamine, riboflavin, niacinamide, pantothenic acid, pyridoxine, folic acid and ascorbic acid in Vitamins with Minerals Tablets by high-performance liquid chromatography with diode array detector. J Pharm Biomed Anal. 2012;70:151-7 pubmed publisher
    ..Method comparison indicated good concordance between the developed method and the USP method. The developed method was reliable and convenient for the rapid determination of VB(1), VB(3), VB(6), VC, VB(5), VB(2) and VB(9) in VMT. ..
  30. Masuda S, Eda S, Ikeda S, Mitsui H, Minamisawa K. Thiosulfate-dependent chemolithoautotrophic growth of Bradyrhizobium japonicum. Appl Environ Microbiol. 2010;76:2402-9 pubmed publisher
    ..japonicum USDA110...
  31. Ramírez Zambrano E, Zambrano E, Rojas G, Zambrano M, Teneud L. [Protective effect of melatonin and sodium thiosulphate on histopathology and ultrastructure of the kidney in rats with acute paraquat poisoning]. Invest Clin. 2007;48:81-9 pubmed
    ..In consequence, more experiments with these drugs are necessary to considere them as specific treatments in cases of poisoning by paraquat...
  32. Wang J, Feng X, Anderson C, Qiu G, Ping L, Bao Z. Ammonium thiosulphate enhanced phytoextraction from mercury contaminated soil--results from a greenhouse study. J Hazard Mater. 2011;186:119-27 pubmed publisher
  33. Elias Samlalsingh N, Agard J. Application of toxicity identification evaluation procedures for characterizing produced water using the tropical mysid, Metamysidopsis insularis. Environ Toxicol Chem. 2004;23:1194-203 pubmed
    ..5 microm). This investigation is the first of its type in Trinidad and demonstrates clearly the applicability of this test method and local test species for evaluating complex effluents in tropical environments...
  34. Maróti J, Farkas A, Nagy I, Maroti G, Kondorosi E, RAKHELY G, et al. A second soluble Hox-type NiFe enzyme completes the hydrogenase set in Thiocapsa roseopersicina BBS. Appl Environ Microbiol. 2010;76:5113-23 pubmed publisher
    ..However, under nitrogen-fixing conditions, it can oxidize H(2) but less than the other hydrogenases in the cell...
  35. Zhang Y, Leng Y, Miao L, Xin J, Wu A. The colorimetric detection of Pb2+ by using sodium thiosulfate and hexadecyl trimethyl ammonium bromide modified gold nanoparticles. Dalton Trans. 2013;42:5485-90 pubmed publisher
    ..Moreover, this detection method is simple, cheap and environmentally friendly...
  36. Sooriyaarachchi M, Narendran A, Gailer J. The effect of sodium thiosulfate on the metabolism of cis-platin in human plasma in vitro. Metallomics. 2012;4:960-7 pubmed publisher
    ..Our results demonstrate that in vitro studies can be useful to develop feasible strategies to mitigate the side-effects of Pt-based anticancer drugs in patients...
  37. Stanciu M, Gagné Henley A, Thérien G. Unusual case of proximal calciphylaxis without renal failure. J Cutan Med Surg. 2011;15:290-2 pubmed
    ..It usually manifests as a complication of end-stage renal failure, affecting 1 to 4% of long-term dialysis patients. Very exceptionally, it can occur without chronic renal failure...
  38. Sorokin D, Detkova E, Muyzer G. Sulfur-dependent respiration under extremely haloalkaline conditions in soda lake 'acetogens' and the description of Natroniella sulfidigena sp. nov. FEMS Microbiol Lett. 2011;319:88-95 pubmed publisher
    ..This finding, once again, exemplifies the importance of isolation and phenotypic investigation of pure cultures...
  39. Cai X, Sheng G, Liu W. Degradation and detoxification of acetochlor in soils treated by organic and thiosulfate amendments. Chemosphere. 2007;66:286-92 pubmed
    ..Further tests show that both degradates were less toxic to green algae than acetochlor. Both organic and STS amendments thus effectively degrade and detoxify acetochlor in soils...
  40. Pandey S, Narayan K, Bandyopadhyay S, Nayak K, Das S. Thiosulfate oxidation by Comamonas sp. S23 isolated from a sulfur spring. Curr Microbiol. 2009;58:516-21 pubmed publisher
    ..Polymerase chain reaction (PCR) using soxB-specific primers and DNA sequencing showed the presence of the soxB gene. This is the first report in Comamonas sp. showing thiosulfate oxidation under a mixotrophic growth condition...
  41. Perreault N, Greer C, Andersen D, Tille S, Lacrampe Couloume G, Lollar B, et al. Heterotrophic and autotrophic microbial populations in cold perennial springs of the high arctic. Appl Environ Microbiol. 2008;74:6898-907 pubmed publisher
  42. Sykes J, Ramsay E. Attempted treatment of tigers (Panthera tigris) infected with Microsporum canis. J Zoo Wildl Med. 2007;38:252-7 pubmed
  43. Moreno F, Anderson C, Stewart R, Robinson B. Mercury volatilisation and phytoextraction from base-metal mine tailings. Environ Pollut. 2005;136:341-52 pubmed
    ..A preliminary assessment of the risks of volatilisation indicated that enhanced Hg emissions by plants would not harm the local population and the regional environment...
  44. Surkov A, Bottcher M, Kuever J. Sulphur isotope fractionation during the reduction of elemental sulphur and thiosulphate by Dethiosulfovibrio spp. Isotopes Environ Health Stud. 2012;48:65-75 pubmed publisher
    ..3 and 3 fmol S° cell(-1) d(-1))...
  45. Rosenkranz A, Grobner T, Mayer G. Conventional or Gadolinium containing contrast media: the choice between acute renal failure or Nephrogenic Systemic Fibrosis?. Wien Klin Wochenschr. 2007;119:271-5 pubmed
  46. Meissner M, Kaufmann R, Gille J. Sodium thiosulphate: a new way of treatment for calciphylaxis?. Dermatology. 2007;214:278-82 pubmed
    ..The goal of this article is to review the new application possibility of this compound...
  47. Cappaert N, Klis S, Wijbenga J, Smoorenburg G. Acceleration of cisplatin ototoxicity by perilymphatic application of 4-methylthiobenzoic acid. Hear Res. 2005;203:80-7 pubmed
    ..In contrast to MTBA, STS ameliorated the ototoxic effect of cisplatin. In conclusion, local application of anti-oxidants can ameliorate cisplatin ototoxicity but this is not a feature of all anti-oxidants...
  48. Zhang Z, Zhang J, Lou T, Pan D, Chen L, Qu C, et al. Label-free colorimetric sensing of cobalt(II) based on inducing aggregation of thiosulfate stabilized gold nanoparticles in the presence of ethylenediamine. Analyst. 2012;137:400-5 pubmed publisher
    ..1 to 0.7 ?M. The cost-effective method allows rapid and simple determination of the concentrations of Co(2+) ions in drinking water...
  49. Tokashiki K, Ishida A, Kouchi M, Ishihara S, Tomiyama N, Kohagura K, et al. Successful management of critical limb ischemia with intravenous sodium thiosulfate in a chronic hemodialysis patient. Clin Nephrol. 2006;66:140-3 pubmed
    ..Pain relief was sustained and he could walk after 2 weeks of infusion. Our case supports the use of sodium thiosulfate as a novel therapeutic choice for critical limb ischemia with severe vascular calcification in chronic HD patients...
  50. Toombs C, Insko M, Wintner E, Deckwerth T, Usansky H, Jamil K, et al. Detection of exhaled hydrogen sulphide gas in healthy human volunteers during intravenous administration of sodium sulphide. Br J Clin Pharmacol. 2010;69:626-36 pubmed publisher
    ..In the current study, we have measured H(2)S concentrations in the exhaled breath of healthy human volunteers subjected to increasing doses sodium sulphide in a human phase I safety and tolerability study...
  51. Horstkotte B, Tovar Sanchez A, Duarte C, Cerdà V. Sequential injection analysis for automation of the Winkler methodology, with real-time SIMPLEX optimization and shipboard application. Anal Chim Acta. 2010;658:147-55 pubmed publisher
    ..The analytical system featured high signal stability, robustness, and a repeatability of 3% RSD (1st mode) and 0.8% (2nd mode) during shipboard application...
  52. Ghosh W, Roy P. Mesorhizobium thiogangeticum sp. nov., a novel sulfur-oxidizing chemolithoautotroph from rhizosphere soil of an Indian tropical leguminous plant. Int J Syst Evol Microbiol. 2006;56:91-7 pubmed
    ..It is therefore proposed that isolate SJT(T) (= LMG 22697T = MTCC 7001T) be classified as the type strain of a novel species, Mesorhizobium thiogangeticum sp. nov...
  53. Qin R, Gao S, Hanson B, McDonald J, Trout T, Ajwa H. Effect of drip application of ammonium thiosulfate on fumigant degradation in soil columns. J Agric Food Chem. 2007;55:8193-9 pubmed
    ..This technical solution may be applicable in raised-bed strawberry production where drip-application of fumigants under tarps has become common...