copper sulfate

Summary

Summary: A sulfate salt of copper. It is a potent emetic and is used as an antidote for poisoning by phosphorus. It also can be used to prevent the growth of algae.

Top Publications

  1. Hasman H, Kempf I, Chidaine B, Cariolet R, Ersbøll A, Houe H, et al. Copper resistance in Enterococcus faecium, mediated by the tcrB gene, is selected by supplementation of pig feed with copper sulfate. Appl Environ Microbiol. 2006;72:5784-9 pubmed
    ..faecium in the animal group fed the high level of copper. Finally, we identify the tcr genes in the enterococcal species E. mundtii, E. casseliflavus, and E. gallinarum for the first time...
  2. Käkinen A, Bondarenko O, Ivask A, Kahru A. The effect of composition of different ecotoxicological test media on free and bioavailable copper from CuSO4 and CuO nanoparticles: comparative evidence from a Cu-selective electrode and a Cu-biosensor. Sensors (Basel). 2011;11:10502-21 pubmed publisher
    ..Our results demonstrate that bacterial Cu-biosensors either in combination with other analytical/speciation techniques or on their own, may serve as a rapid (eco)toxicological screening method...
  3. Shelton N, Tokach M, Nelssen J, Goodband R, Dritz S, DeRouchey J, et al. Effects of copper sulfate, tri-basic copper chloride, and zinc oxide on weanling pig performance. J Anim Sci. 2011;89:2440-51 pubmed publisher
    ..3, when 3,000 mg/kg of Zn was added early and 125 mg/kg of Cu was added late, performance was similar or numerically greater than when both were used for 42 d...
  4. Qian H, Yu S, Sun Z, Xie X, Liu W, Fu Z. Effects of copper sulfate, hydrogen peroxide and N-phenyl-2-naphthylamine on oxidative stress and the expression of genes involved photosynthesis and microcystin disposition in Microcystis aeruginosa. Aquat Toxicol. 2010;99:405-12 pubmed publisher
    ..Chemical remediation is one of most important methods of controlling algal bloom formation. The effects of copper sulfate, hydrogen peroxide (H(2)O(2)) and N-phenyl-2-naphthylamine on photosynthesis-related and microcystin-related ..
  5. Alcaraz Zubeldia M, Boll Woehrlen M, Montes López S, Perez Severiano F, Martínez Lazcano J, Diaz Ruiz A, et al. Copper sulfate prevents tyrosine hydroxylase reduced activity and motor deficits in a Parkinson's disease model in mice. Rev Invest Clin. 2009;61:405-11 pubmed
  6. Al Holy M, Castro L, Al Qadiri H. Inactivation of Cronobacter spp. (Enterobacter sakazakii) in infant formula using lactic acid, copper sulfate and monolaurin. Lett Appl Microbiol. 2010;50:246-51 pubmed publisher
    ..To investigate the effect of lactic acid (LA), copper (II), and monolaurin as natural antimicrobials against Cronobacter in infant formula...
  7. Gould S, Fielder M, Kelly A, Naughton D. Anti-microbial activities of pomegranate rind extracts: enhancement by cupric sulphate against clinical isolates of S. aureus, MRSA and PVL positive CA-MSSA. BMC Complement Altern Med. 2009;9:23 pubmed publisher
    ..Recently, natural products have been evaluated as sources of antimicrobial agents with efficacies against a variety of micro-organisms...
  8. Baumgartner S, Wolf M, Skrabal P, Bangerter F, Heusser P, Thurneysen A, et al. High-field 1H T(1) and T(2) NMR relaxation time measurements of H2O in homeopathic preparations of quartz, sulfur, and copper sulfate. Naturwissenschaften. 2009;96:1079-89 pubmed publisher
    ..21, corresponding to iterative dilutions of 100(-10)-100(-30)), sulfur (13x-30x, n = 18, 10(-13)-10(-30)), and copper sulfate (11c-30c, n = 20, 100(-11)-100(-30)) were compared to n = 10 independent controls each (analogously agitated ..
  9. Park K, Heo G. Acute and subacute toxicity of copper sulfate pentahydrate (CuSO(4)5.H(2)O) in the guppy (Poecilia reticulata). J Vet Med Sci. 2009;71:333-6 pubmed
    Chemicals are used for treatment of aquatic diseases, but there is little data available about copper sulfate in small ornamental fish...

More Information

Publications62

  1. García Muñoz E, Guerrero F, Parra G. Effects of copper sulfate on growth, development, and escape behavior in Epidalea calamita embryos and larvae. Arch Environ Contam Toxicol. 2009;56:557-65 pubmed publisher
    Epidalea calamita embryos at Gosner stages 3 and 19, and larvae at Gosner stage 25, were exposed to different copper sulfate concentrations, ranging from 0.05 to 0.40 mg Cu L(-1), in 96-h acute toxicity tests...
  2. Burke J, Miller J. Dietary copper sulfate for control of gastrointestinal nematodes in goats. Vet Parasitol. 2008;154:289-93 pubmed publisher
    ..The objective was to determine the effectiveness of dietary copper sulfate for control of GIN in meat goats...
  3. Ji C, Cao C, Lu S, Kivlin R, Amaral A, Kouttab N, et al. Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells. Cancer Chemother Pharmacol. 2008;62:857-65 pubmed publisher
  4. Broos K, Warne M, Heemsbergen D, Stevens D, Barnes M, Correll R, et al. Soil factors controlling the toxicity of copper and zinc to microbial processes in Australian soils. Environ Toxicol Chem. 2007;26:583-90 pubmed
  5. Horn C, Meyers K, Lim A, Dye M, Pak D, Rinaman L, et al. Delineation of vagal emetic pathways: intragastric copper sulfate-induced emesis and viral tract tracing in musk shrews. Am J Physiol Regul Integr Comp Physiol. 2014;306:R341-51 pubmed publisher
    ..g., chemotherapy) often act on multiple sensory pathways. Intragastric copper sulfate (CuSO4) potentially provides a specific vagal emetic stimulus, but its actions are not well defined in musk ..
  6. Qian Y, Khattak S, Xing Z, He A, Kayne P, Qian N, et al. Cell culture and gene transcription effects of copper sulfate on Chinese hamster ovary cells. Biotechnol Prog. 2011;27:1190-4 pubmed publisher
    This study reports the effects of varying concentrations of copper sulfate on the metabolic and gene transcriptional profile of a recombinant Chinese hamster ovary (CHO) cell line producing an immunoglobulin G (IgG)-fusion protein (B0)...
  7. Gupte A, Mumper R. Copper chelation by D-penicillamine generates reactive oxygen species that are cytotoxic to human leukemia and breast cancer cells. Free Radic Biol Med. 2007;43:1271-8 pubmed
    ..The H(2)O(2)-mediated cytotoxicity was greater in leukemia cells compared to breast cancer cells. These results support the hypothesis that D-pen can be employed as a cytotoxic copper-chelating agent based on its ROS-generating ability...
  8. Wu S, Jong K, Kuo S. Effects of copper sulfate on ion balance and growth in tilapia larvae (Oreochromis mossambicus). Arch Environ Contam Toxicol. 2003;45:357-63 pubmed
    ..These results obviously show that larvae are sensitive to Cu2+ during early development...
  9. Harada S, Sugiyama E, Taki H, Shinoda K, Fujita T, Maruyama M, et al. D-penicillamine cooperates with copper sulfate to enhance the surface expression of functional Fas antigen in rheumatoid synovial fibroblasts via the generation of hydrogen peroxide. Clin Exp Rheumatol. 2002;20:469-76 pubmed
    ..To determine whether this inhibitory action is involved in Fas-mediated apoptosis, we examined the effect of DP and copper sulfate on the expression and function of Fas antigen in rheumatoid synovial fibroblasts (RSFs).
  10. Reddy A, Ponder E, Fried B. Effects of copper sulfate toxicity on cercariae and metacercariae of Echinostoma caproni and Echinostoma trivolvis and on the survival of Biomphalaria glabrata snails. J Parasitol. 2004;90:1332-7 pubmed
    Copper in the form of copper sulfate (CuSO4) decreases the survival of Biomphalaria glabrata snails, but the effects of this molluscicide on Echinostoma caproni and Echinostoma trivolvis, 2 species of digeneans that use B...
  11. Bunce N, Chartrand M, Keech P. Electrochemical treatment of acidic aqueous ferrous sulfate and copper sulfate as models for acid mine drainage. Water Res. 2001;35:4410-6 pubmed
    ..In the case of CuSO4/H2SO4 and anion exchange membranes at high currents, reduction of Cu2+ and H+ ions and transport of SO4(2-) ions out of the catholyte caused unacceptably high potentials to be generated...
  12. Aarestrup F, Hasman H. Susceptibility of different bacterial species isolated from food animals to copper sulphate, zinc chloride and antimicrobial substances used for disinfection. Vet Microbiol. 2004;100:83-9 pubmed
  13. Besnard E, Chenu C, Robert M. Influence of organic amendments on copper distribution among particle-size and density fractions in Champagne vineyard soils. Environ Pollut. 2001;112:329-37 pubmed
    The intensive use for over 100 years of copper sulfate (Bordeaux mixture) to fight against mildew in vineyard soils has led to an important, widespread accumulation of Cu (100 to 1500 mg Cu kg-1 soil)...
  14. Averbeck N, Borghouts C, Hamann A, Specke V, Osiewacz H. Molecular control of copper homeostasis in filamentous fungi: increased expression of a metallothionein gene during aging of Podospora anserina. Mol Gen Genet. 2001;264:604-12 pubmed
    ..The ability of wild-type cultures to respond to exogenous copper stress via the induction of PaMt1 transcription is not affected as they grow older...
  15. Michaud J, Angela K G. Sub-lethal effects of a copper sulfate fungicide on development and reproduction in three coccinellid species. J Insect Sci. 2003;3:16 pubmed
    ..We exposed the larvae of three species of ladybeetle (Coleoptera: Coccinellidae) to field rates of copper sulfate in combination with petroleum oil, a formulation commonly applied in Florida citrus...
  16. Miles R, O Keefe S, Henry P, Ammerman C, Luo X. The effect of dietary supplementation with copper sulfate or tribasic copper chloride on broiler performance, relative copper bioavailability, and dietary prooxidant activity. Poult Sci. 1998;77:416-25 pubmed
    ..Oxidation promotion by Cu sulfate was much greater with fine than in coarse sized particles for all three fortification levels...
  17. Mohanapriya S, Senthilkumar P, Sivakumar S, Dineshkumar M, Subbhuraam C. Effects of copper sulfate and copper nitrate in aquatic medium on the restoration potential and accumulation of copper in stem cuttings of the terrestrial medicinal plant, Portulaca oleracea linn. Environ Monit Assess. 2006;121:233-44 pubmed
    ..Accumulation of copper increased with increasing concentrations of both copper sulfate and copper nitrate...
  18. Højberg O, Canibe N, Poulsen H, Hedemann M, Jensen B. Influence of dietary zinc oxide and copper sulfate on the gastrointestinal ecosystem in newly weaned piglets. Appl Environ Microbiol. 2005;71:2267-77 pubmed
    ..Dietary CuSO(4) inhibited the coliforms and thus potential pathogens as well, but overall the observed effect of CuSO(4) was limited compared to that of ZnO...
  19. Miller N, Dick J, Merz W. Phenotypic switching in Candida lusitaniae on copper sulfate indicator agar: association with amphotericin B resistance and filamentation. J Clin Microbiol. 2006;44:1536-9 pubmed
    ..Phenotypic switching represents a key strategy in C. lusitaniae that confers a selective advantage during environmental challenges, including the ability to switch to AmB resistance...
  20. Yu W, Farrell R, Stillman D, Winge D. Identification of SLF1 as a new copper homeostasis gene involved in copper sulfide mineralization in Saccharomyces cerevisiae. Mol Cell Biol. 1996;16:2464-72 pubmed
    ..This process may coordinate with the Cup1 pathway at different copper concentrations to prevent copper-induced toxicity...
  21. Sitasawad S, Deshpande M, Katdare M, Tirth S, Parab P. Beneficial effect of supplementation with copper sulfate on STZ-diabetic mice (IDDM). Diabetes Res Clin Pract. 2001;52:77-84 pubmed
    ..The aim of this study was to evaluate the potential usefulness of copper sulfate in the treatment of STZ-induced type I diabetes...
  22. Alcaraz Zubeldia M, Montes S, Rios C. Participation of manganese-superoxide dismutase in the neuroprotection exerted by copper sulfate against 1-methyl 4-phenylpyridinium neurotoxicity. Brain Res Bull. 2001;55:277-9 pubmed
    ..The results suggest that the load of copper activating manganese-dependent superoxide dismutase could be responsible for neuroprotection against the MPP+ insult...
  23. Ikeda K, Nakayashiki H, Takagi M, Tosa Y, Mayama S. Heat shock, copper sulfate and oxidative stress activate the retrotransposon MAGGY resident in the plant pathogenic fungus Magnaporthe grisea. Mol Genet Genomics. 2001;266:318-25 pubmed
    ..The MAGGY promoter was activated in M. grisea by either heat shock, copper sulfate, or oxidative stress, but not by the antifungal substance p-coumaric acid...
  24. Murray Gulde C, Heatley J, Schwartzman A, Rodgers J. Algicidal effectiveness of Clearigate, Cutrine-Plus, and copper sulfate and margins of safety associated with their use. Arch Environ Contam Toxicol. 2002;43:19-27 pubmed
    ..to determine the contact time required for these copper-containing algicides (Clearigate, Cutrine-Plus, and copper sulfate) and the target species to obtain control; (3) to measure the critical burden of the three algicides required ..
  25. Seok S, Park J, Baek M, Lee H, Kim D, Uhm H, et al. Specific activation of the human HSP70 promoter by copper sulfate in mosaic transgenic zebrafish. J Biotechnol. 2006;126:406-13 pubmed
    ..b>Copper sulfate inducibility of a pHhsp70 construct expressing the enhanced green fluorescent protein (EGFP) gene under the ..
  26. Alvarez S, Jerez C. Copper ions stimulate polyphosphate degradation and phosphate efflux in Acidithiobacillus ferrooxidans. Appl Environ Microbiol. 2004;70:5177-82 pubmed
    ..ferrooxidans...
  27. Veum T, Carlson M, Wu C, Bollinger D, Ellersieck M. Copper proteinate in weanling pig diets for enhancing growth performance and reducing fecal copper excretion compared with copper sulfate. J Anim Sci. 2004;82:1062-70 pubmed
    ..2, compared with 250 ppm Cu as CuSO4. However, 50 or 100 ppm Cu as Cu-proteinate increased Cu absorption and retention, and decreased Cu excretion 77 and 61%, respectively, compared with 250 ppm Cu as CuSO4...
  28. Yao Y, Sakamoto T, Honda Y, Kagotani Y, Izumitsu K, Suzuki K, et al. The white-rot fungus pleurotus ostreatus transformant overproduced intracellular cAMP and laccase. Biosci Biotechnol Biochem. 2013;77:2309-11 pubmed
    ..The transformant also exhibited higher Lac activity than the wild type when cultured in a medium containing known Lac inducers CuSO4 and ferulic acid. ..
  29. Calisi A, Lionetto M, Schettino T. Biomarker response in the earthworm Lumbricus terrestris exposed to chemical pollutants. Sci Total Environ. 2011;409:4456-64 pubmed publisher
  30. Liu C, Yeh S, Hsu P, Cheng W. Peroxinectin gene transcription of the giant freshwater prawn Macrobrachium rosenbergii under intrinsic, immunostimulant, and chemotherapeutant influences. Fish Shellfish Immunol. 2007;22:408-17 pubmed
    ..3-1.0 mgL(-1) BKC after 96 h, and 0.2-0.4 mgL(-1) trichlorfon after 48 h. It was concluded that the status of PE gene expression was seriously affected by the moult cycle, immunostimulant, and chemotherapeutants...
  31. Ando K, Takagi K. Solid gastric emptying mediated by the serotonin (5-HT)3 receptor in mice is a simple marker to predict emesis. J Toxicol Sci. 2011;36:23-9 pubmed
    ..1-3 mg/kg i.p.; salmon calcitonin, 1-30 units/kg i.m.), nauseants (copper sulfate, 1-30 mg/kg p.o.; apomorphine, 0.01-0.3 mg/kg s.c.) and chemotherapeutics (cisplatin, 0.3-10 mg/kg i.v...
  32. Mezghanni H, Khedher S, Tounsi S, Zouari N. Medium optimization of antifungal activity production by Bacillus amyloliquefaciens using statistical experimental design. Prep Biochem Biotechnol. 2012;42:267-78 pubmed publisher
  33. Guilarte T, Chen M. Manganese inhibits NMDA receptor channel function: implications to psychiatric and cognitive effects. Neurotoxicology. 2007;28:1147-52 pubmed
  34. de Rauglaudre G, Courdi A, Delaby Chagrin F, d Hombres A, Hannoun Levi J, Moureau Zabotto L, et al. [Tolerance of the association sucralfate / Cu-Zn salts in radiation dermatitis]. Ann Dermatol Venereol. 2008;Spec No 1:11-5 pubmed publisher
    ..Thus, topical application of the combination sucralfate / copper zinc salts can be used in the indication radiation dermatitis...
  35. Andreazza R, Okeke B, Pieniz S, Bento F, Camargo F. Biosorption and bioreduction of copper from different copper compounds in aqueous solution. Biol Trace Elem Res. 2013;152:411-6 pubmed publisher
    ..This is an indication that copper contamination of the environment from the use of CuSO4 as an agrochemical is amenable to bioremediation...
  36. Liang L, Li Z, Zhou X. Pyridine N-oxides as ligands in Cu-catalyzed N-arylation of imidazoles in water. Org Lett. 2009;11:3294-7 pubmed publisher
    ..N-arylation of imidazoles with aryl halides catalyzed by a combination of copper(II) sulfate and 1,2-bis(2-pyridyl)-ethane-N,N'-dioxide in water afforded up to 95% yield...
  37. Sáez M, García Mesa S, Casas J, Guil Guerrero J, Venegas Venegas C, Morales A, et al. Effect of sublethal concentrations of waterborne copper on lipid peroxidation and enzymatic antioxidant response in Gambusia holbrooki. Environ Toxicol Pharmacol. 2013;36:125-34 pubmed publisher
    ..This leads us to presume the existence of a protective mechanism against peroxidation other than the enzymatic antioxidant defense, which could be related to the observed increase of copper content in the gills...
  38. Wang Y, Zhang L, Yao J, Huang Y, Yan M. Accumulation and resistance to copper of two biotypes of Cynodon dactylon. Bull Environ Contam Toxicol. 2009;82:454-9 pubmed publisher
    ..At 500 mg/kg copper concentration in soil, the biotype from the polluted area showed significantly higher tolerance of copper than the biotype from the unpolluted area...
  39. Ishimoto S, Wada K, Usami Y, Tanaka N, Aikawa T, Okura M, et al. Differential expression of aquaporin 5 and aquaporin 3 in squamous cell carcinoma and adenoid cystic carcinoma. Int J Oncol. 2012;41:67-75 pubmed publisher
    ..AQPs play important roles in cell growth in SCC rather than ACC...
  40. Kubisch R, Bohrn U, Fleischer M, Stütz E. Cell-based sensor system using L6 cells for broad band continuous pollutant monitoring in aquatic environments. Sensors (Basel). 2012;12:3370-93 pubmed publisher
    ..The results support the paradigm change from single substance detection to the monitoring of overall toxicity...
  41. Naha K, Saravu K, Shastry B. Blue vitriol poisoning: a 10-year experience in a tertiary care hospital. Clin Toxicol (Phila). 2012;50:197-201 pubmed publisher
    ..This study was planned to identify common presentations and complications of copper sulphate poisoning, and biochemical parameters that predict outcomes in these patients...
  42. Satyaparameshwar K, Ravinder Reddy T, Vijaya Kumar N. Study of carbohydrate metabolism in selected tissues of freshwater mussel, Lamellidens marginalis under copper sulphate toxicity. J Environ Biol. 2006;27:39-41 pubmed
    ..Activities of LDH, SDH and MDH decreased while G-6-PDH activity increased. There appears to be a shift in the carbohydrate metabolism from aerobic to anaerobic type due to toxicity of copper...
  43. Calatayud M, Barrios J, Velez D, Devesa V. In vitro study of transporters involved in intestinal absorption of inorganic arsenic. Chem Res Toxicol. 2012;25:446-53 pubmed publisher
    ..using rifamycin SV (OATP inhibitor), phloridzin (SGLT inhibitor), phloretin (GLUT and AQP inhibitor), and copper sulfate (AQP inhibitor) leads to a significant reduction in the apparent permeability and cellular retention of As(III)..
  44. Sawant R, Bharucha Z, Rajadhyaksha S. Evaluation of hemoglobin of blood donors deferred by the copper sulphate method for hemoglobin estimation. Transfus Apher Sci. 2007;36:143-8 pubmed
    ..The copper sulphate (CuSO4) specific gravity test for Hb screening tends to give inappropriate failures. This prompted us to compare it with alternate screening methods...
  45. Surwase S, Jadhav J. Bioconversion of L-tyrosine to L-DOPA by a novel bacterium Bacillus sp. JPJ. Amino Acids. 2011;41:495-506 pubmed publisher
    ..This is the first report on rapid and efficient production of L-DOPA from L-tyrosine by bacterial source which is more effective than the plant, fungal and yeast systems...
  46. Kumar P, Prasad B, Mishra I, Chand S. Catalytic thermal treatment of desizing wastewaters. J Hazard Mater. 2007;149:26-34 pubmed
    ..The experimental runs were performed in a glass reactor equipped with a vertical condenser. The homogeneous copper sulfate catalyst was found to be the most active in comparison to other catalysts under similar operating conditions...
  47. Marschollek B, Nelle M, Wolf M, Baumgartner S, Heusser P, Wolf U. Effects of exposure to physical factors on homeopathic preparations as determined by ultraviolet light spectroscopy. ScientificWorldJournal. 2010;10:49-61 pubmed publisher
    ..Homeopathic centesimal (c) dilutions, 1c to 30c, of copper sulfate (CuSO(4)), decimal dilutions of sulfur (S(8)), 1x to 30x, and controls (succussed potentization medium) were ..
  48. Olivares M, Pizarro F, Lopez de Romaña D, Ruz M. Acute copper supplementation does not inhibit non-heme iron bioavailability in humans. Biol Trace Elem Res. 2010;136:180-6 pubmed publisher
    ..Subjects received 0.5 mg of Fe, as ferrous sulfate, alone or with Cu, as copper sulfate, at 0...
  49. Tollett V, Benvenutti E, Deer L, Rice T. Differential toxicity to Cd, Pb, and Cu in dragonfly larvae (Insecta: Odonata). Arch Environ Contam Toxicol. 2009;56:77-84 pubmed publisher
    ..Based on their abundance and their simple requirements in the laboratory, we believe that odonate larvae can be useful toxicological model organisms...
  50. Wolschendorf F, Ackart D, Shrestha T, Hascall Dove L, Nolan S, Lamichhane G, et al. Copper resistance is essential for virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2011;108:1621-6 pubmed publisher
    ..Hence, this study reveals an Achilles heel of Mtb that might be a promising target for tuberculosis chemotherapy...
  51. Oguz E, Yuksel H, Enli Y, Tufan A, Turgut G. The effects of copper sulfate on liver histology and biochemical parameters of term Ross broiler chicks. Biol Trace Elem Res. 2010;133:335-41 pubmed publisher
    ..We have investigated the histological and biochemical effects of a toxic dose of copper sulfate on the liver of term Ross broiler chicks...
  52. Schäfer S, Bickmeyer U, Koehler A. Measuring Ca2+-signalling at fertilization in the sea urchin Psammechinus miliaris: alterations of this Ca2+-signal by copper and 2,4,6-tribromophenol. Comp Biochem Physiol C Toxicol Pharmacol. 2009;150:261-9 pubmed publisher
    ..This alteration may contribute to the reduced fertilization rates of P. miliaris after exposure to copper and 2,4,6-tribromophenol...
  53. Oliva M, Garrido M, Sales Márquez D, Gonzalez de Canales M. Sublethal and lethal toxicity in juvenile Senegal sole (Solea senegalensis) exposed to copper: a preliminary toxicity range-finding test. Exp Toxicol Pathol. 2009;61:113-21 pubmed publisher
    ..senegalensis to copper (II), the persistence of sublethal effects and histology as a tool capable of revealing the sublethal effects of heavy metals on the environment and aquatic biota...