tert butylhydroperoxide


Summary: A direct-acting oxidative stress-inducing agent used to examine the effects of oxidant stress on Ca(2+)-dependent signal transduction in vascular endothelial cells. It is also used as a catalyst in polymerization reactions and to introduce peroxy groups into organic molecules.

Top Publications

  1. Pérez L, Milkiewicz P, Ahmed Choudhury J, Elias E, Ochoa J, Sanchez Pozzi E, et al. Oxidative stress induces actin-cytoskeletal and tight-junctional alterations in hepatocytes by a Ca2+ -dependent, PKC-mediated mechanism: protective effect of PKA. Free Radic Biol Med. 2006;40:2005-17 pubmed
    ..We conclude that ROS induce hepatocellular actin-cytoskeleton rearrangement and tight-junctional impairment by a PKC-mediated, Ca2+ -dependent mechanism, which is counteracted by PKA. ..
  2. Hwang Y, Yun H, Chun H, Chung Y, Kim H, Jeong M, et al. Protective mechanisms of 3-caffeoyl, 4-dihydrocaffeoyl quinic acid from Salicornia herbacea against tert-butyl hydroperoxide-induced oxidative damage. Chem Biol Interact. 2009;181:366-76 pubmed publisher
  3. Zhao K, Zhao G, Wu D, Soong Y, Birk A, Schiller P, et al. Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury. J Biol Chem. 2004;279:34682-90 pubmed
    ..These IMM-targeted antioxidants may be very beneficial in the treatment of aging and diseases associated with oxidative stress. ..
  4. Alía M, Ramos S, Mateos R, Bravo L, Goya L. Response of the antioxidant defense system to tert-butyl hydroperoxide and hydrogen peroxide in a human hepatoma cell line (HepG2). J Biochem Mol Toxicol. 2005;19:119-28 pubmed
    ..The response of the components of the antioxidant defense system evaluated in this study indicates that tert-butyl hydroperoxide evokes a consistent cellular stress in HepG2. ..
  5. Panasenko O, Chekanov A, Arnhold J, Sergienko V, Osipov A, Vladimirov Y. Generation of free radicals during decomposition of hydroperoxide in the presence of myeloperoxidase or activated neutrophils. Biochemistry (Mosc). 2005;70:998-1004 pubmed
  6. Peterson B, Stovall K, Monian P, Franklin J, Cummings B. Alterations in phospholipid and fatty acid lipid profiles in primary neocortical cells during oxidant-induced cell injury. Chem Biol Interact. 2008;174:163-76 pubmed publisher
    ..Collectively, these data identify phospholipids and fatty acids altered during oxidant treatment of neurons and suggest differential roles for Group IV and VI PLA(2) in oxidant-induced neural cell injury. ..
  7. Whyte K, Hogg R, Dyavanapalli J, Harper A, Adams D. Reactive oxygen species modulate neuronal excitability in rat intrinsic cardiac ganglia. Auton Neurosci. 2009;150:45-52 pubmed publisher
    ..This affects action potential duration and therefore probably modifies autonomic control of the heart during ischemia/reperfusion. ..
  8. Lee K, Chung K, Chung J. Involvement of reactive oxygen species in long-term potentiation in the spinal cord dorsal horn. J Neurophysiol. 2010;103:382-91 pubmed publisher
    ..The data suggest that elevated ROS is a downstream event of NMDA receptor activation and an essential step for potentiation of synaptic excitability in the spinal dorsal horn. ..
  9. Nicotera P, McConkey D, Svensson S, Bellomo G, Orrenius S. Correlation between cytosolic Ca2+ concentration and cytotoxicity in hepatocytes exposed to oxidative stress. Toxicology. 1988;52:55-63 pubmed
    ..Our findings provide further support for the hypothesis that a perturbation of intracellular Ca2+ homeostasis is an early and critical event in the development of toxicity in hepatocytes exposed to oxidative stress. ..

More Information

Publications108 found, 100 shown here

  1. Lemasters J, Nieminen A, Qian T, Trost L, Elmore S, Nishimura Y, et al. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta. 1998;1366:177-96 pubmed
    ..A model is proposed in which onset of the MPT to increasing numbers of mitochondria within a cell leads progressively to autophagy, apoptosis and necrotic cell death. ..
  2. Chen H, Chiang T, Wang C, Lii C. Inhibition of tert-butyl hydroperoxide-induced cell membrane bleb formation by alpha-tocopherol and glutathione. Food Chem Toxicol. 2000;38:1089-96 pubmed
    ..These results indicated that intracellular GSH and alpha-tocopherol status are important to the TBH-induced cell membrane abnormality. Furthermore, TS plays a defensive role against blebbing when GSH is exhausted by TBH. ..
  3. Sonee M, Martens J, Evers M, Mukherjee S. The effect of tertiary butylhydroperoxide and nicotinamide on human cortical neurons. Neurotoxicology. 2003;24:443-8 pubmed
    ..However nicotinamide did not seem to alter bcl-2 levels. These results indicate that nicotinamide treatment can protect human neuronal cells from the toxic effects of t-BuOOH. ..
  4. Yen G, Yeh C, Chen Y. Protective effect of Mesona procumbens against tert-butyl hydroperoxide-induced acute hepatic damage in rats. J Agric Food Chem. 2004;52:4121-7 pubmed
    ..On the basis of the results of this study, it can be speculated that M. procumbens protects liver against t-BHP-induced hepatic damage in rats. ..
  5. Maher P, Hanneken A. Flavonoids protect retinal ganglion cells from oxidative stress-induced death. Invest Ophthalmol Vis Sci. 2005;46:4796-803 pubmed
    ..These results suggest that certain flavonoids can function as potent and effective neuroprotective agents for retinal ganglion cells. ..
  6. Dombrecht E, De Tollenaere C, Aerts K, Cos P, Schuerwegh A, Bridts C, et al. Antioxidant effect of bisphosphonates and simvastatin on chondrocyte lipid peroxidation. Biochem Biophys Res Commun. 2006;348:459-64 pubmed
    ..These findings add evidence to the therapeutic potential of bisphosphonates and statins in rheumatoid arthritis. ..
  7. Fekete A, Pocsi I, Emri T, Gyetvai A, Gazdag Z, Pesti M, et al. Physiological and morphological characterization of tert -butylhydroperoxide tolerant Candida albicans mutants. J Basic Microbiol. 2008;48:480-7 pubmed publisher
    ..albicans strains more tolerant of oxidative stress is unlikely. Not surprisingly, a screening study failed to detect any C. albicans strains with increased oxidative stress tolerance among 46 randomly selected clinical isolates. ..
  8. Zhao X, Zhang Y, Deng J, Zhang Negrerie D, Du Y. TBHP/TBAI-Mediated Oxidative Cascade Reaction Consisting of Dimerization, Cyclization, and 1,2-Aryl Migration: Metal-Free Synthesis of Pyrrolin-4-ones and Highly Substituted Pyrroles. J Org Chem. 2017;: pubmed publisher
    ..Upon treatment with a base, the obtained pyrrolin-4-ones could be converted to the highly substituted pyrrole compounds...
  9. Mawatari S, Saito K, Murakami K, Fujino T. Absence of correlation between glycated hemoglobin and lipid composition of erythrocyte membrane in type 2 diabetic patients. Metabolism. 2004;53:123-7 pubmed
  10. Zhao X, Yu H, Yu S, Wang F, Sacchettini J, Magliozzo R. Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant. Biochemistry. 2006;45:4131-40 pubmed
    ..Origins of drug resistance in the KatG[S315T] mutant enzyme are analyzed at the structural level through examination of the three-dimensional X-ray crystal structure of the mutant enzyme. ..
  11. Conway J, Kinter M. Dual role of peroxiredoxin I in macrophage-derived foam cells. J Biol Chem. 2006;281:27991-8001 pubmed
    ..These results are consistent with multiple roles for Prx I in macrophage-derived foam cells that include functionality as both an antioxidant and a regulator of oxidant-sensitive signal transduction. ..
  12. Geetha S, Ram M, Sharma S, Ilavazhagan G, Banerjee P, Sawhney R. Cytoprotective and antioxidant activity of seabuckthorn (Hippophae rhamnoides L.) flavones against tert-butyl hydroperoxide-induced cytotoxicity in lymphocytes. J Med Food. 2009;12:151-8 pubmed publisher
    ..The extract also decreased tert-BOOH-induced formation of DNA breaks by 30%. These observations suggest that the flavones of seabuckthorn have marked cytoprotective properties, which could be attributed to the antioxidant activity. ..
  13. Nakajima T, Davies S, Matafonova E, Potet F, Amarnath V, Tallman K, et al. Selective gamma-ketoaldehyde scavengers protect Nav1.5 from oxidant-induced inactivation. J Mol Cell Cardiol. 2010;48:352-9 pubmed publisher
  14. Martin M, Ramos S, Mateos R, Izquierdo Pulido M, Bravo L, Goya L. Protection of human HepG2 cells against oxidative stress by the flavonoid epicatechin. Phytother Res. 2010;24:503-9 pubmed publisher
    ..Treatment of HepG2 cells with concentrations of EC in the micromolar range confers a significant protection against oxidative stress. ..
  15. Li Y, Wu X, Lee T, Isbell E, Parish E, Gorden A. An effective method for allylic oxidation of Delta5-steroids using tert-butyl hydroperoxide. J Org Chem. 2010;75:1807-10 pubmed publisher
    ..Excellent yields are achieved (up to 99% under optimized conditions) while significantly reducing reaction times required as compared to other current methods. ..
  16. Geetha T, Malhotra V, Chopra K, Kaur I. Antimutagenic and antioxidant/prooxidant activity of quercetin. Indian J Exp Biol. 2005;43:61-7 pubmed
    ..The study indicated that the antimutagenic activity of quercetin was not solely accountable by its antioxidant nature. However, in vitro free radical scavenging activity of quercetin correlated well with the antimutagenic activity. ..
  17. Yamamoto K, Chen Y, Buono F. Oxidative dehydrogenation of dihydropyrimidinones and dihydropyrimidines. Org Lett. 2005;7:4673-6 pubmed
    ..This oxidation procedure is generally applicable to dihydropyrimidinones and most dihydropyrimidines. ..
  18. Sienkiewicz P, Surazynski A, Pałka J, Miltyk W. Nutritional concentration of genistein protects human dermal fibroblasts from oxidative stress-induced collagen biosynthesis inhibition through IGF-I receptor-mediated signaling. Acta Pol Pharm. 2008;65:203-11 pubmed
  19. Valentova K, Sersen F, Ulrichova J. Radical scavenging and anti-lipoperoxidative activities of Smallanthus sonchifolius leaf extracts. J Agric Food Chem. 2005;53:5577-82 pubmed
    ..15-465.3 microg/mL). These results make yacon leaves a good candidate for use as a food supplement in the prevention of chronic diseases involving oxidative stress. ..
  20. Shackelford R, Fu Y, Manuszak R, Brooks T, Sequeira A, Wang S, et al. Iron chelators reduce chromosomal breaks in ataxia-telangiectasia cells. DNA Repair (Amst). 2006;5:1327-36 pubmed
    ..ATM therefore functions in iron responses and the maintenance of genomic stability following labile iron exposure. ..
  21. Yamashiro J, Shiraishi S, Fuwa T, Horie T. Dimerumic acid protected oxidative stress-induced cytotoxicity in isolated rat hepatocytes. Cell Biol Toxicol. 2008;24:283-90 pubmed
    ..Thus, DMA showed an antioxidative effect in hepatocytes and protected against hepatotoxicity by suppressing oxidative stress without affecting CYP enzymes. ..
  22. Sendak R, Ganesa C, Lee K, Harrahy J, Théberge R, Morgan C, et al. The effect of posttranslational modifications on the in vitro activity of recombinant human thyroid-stimulating hormone. Thyroid. 2003;13:1091-101 pubmed
    ..In summary, despite the possible effects that posttranslational modifications may have on the bioactivity of a protein, a limited degree of variation in bioactivity was observed for the rhTSH preparations described in this study. ..
  23. Erlemann K, Rokach J, Powell W. Oxidative stress stimulates the synthesis of the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid by inflammatory cells. J Biol Chem. 2004;279:40376-84 pubmed
    ..Oxidative stress could be an important mechanism for stimulating 5-oxo-ETE production in inflammation, promoting further infiltration of granulocytes into inflammatory sites. ..
  24. Lee J, Yu B, Chung H. Activation mechanisms of endothelial NF-kappaB, IKK, and MAP kinase by tert-butyl hydroperoxide. Free Radic Res. 2005;39:399-409 pubmed
    ..The t-BHP-induced activation of NF-kappaB and MAPK could be a major player in vascular dysfunctions, as seen in oxidative stressed responses and the vascular inflammatory process. ..
  25. Ye Y, Chan Y, Liu H, Lu H, Huang R. Depleted folate pool and dysfunctional mitochondria associated with defective mitochondrial folate proteins sensitize Chinese ovary cell mutants to tert-butylhydroperoxide-induced oxidative stress and apoptosis. J Nutr Biochem. 2010;21:793-800 pubmed publisher
    ..Defective mt SHMT sensitized glyA to respiratory dysfunction and tBH-induced oxidative injury without apoptosis promotion. ..
  26. Rivière J, Ravanat J, Wagner J. Ascorbate and H2O2 induced oxidative DNA damage in Jurkat cells. Free Radic Biol Med. 2006;40:2071-9 pubmed
    ..In conclusion, we report a novel model system in which ascorbate sensitizes H(2)O(2)-induced oxidative DNA damage in cells, leading to elevated levels of oh(5)dCyd and oxo(8)dGuo, with a strong bias toward the formation of oh(5)dCyd. ..
  27. Goya L, Mateos R, Bravo L. Effect of the olive oil phenol hydroxytyrosol on human hepatoma HepG2 cells. Protection against oxidative stress induced by tert-butylhydroperoxide. Eur J Nutr. 2007;46:70-8 pubmed
    ..The results clearly show that treatment of HepG2 cells with the olive oil phenolic HTy may positively affect their antioxidant defense system, favoring cell integrity and resistance to cope with a stressful situation. ..
  28. Babich H, Liebling E, Burger R, Zuckerbraun H, Schuck A. Choice of DMEM, formulated with or without pyruvate, plays an important role in assessing the in vitro cytotoxicity of oxidants and prooxidant nutraceuticals. In Vitro Cell Dev Biol Anim. 2009;45:226-33 pubmed publisher
    ..This study suggested that the pyruvate status of Dulbecco's modified Eagle's medium be specified in the experimental design, especially in studies involving oxidative stress. ..
  29. Fan S, Wei D, Liu J, Xin X, Tong W, Miwa N. Ascorbic acid-2-o-phosphate-6-o-palmitate protecting the human umbilical cord vein endothelial cells against hydrogen peroxide and tert-butyl hydroperoxide induced cytotoxicity. Biomed Pharmacother. 2004;58:205-11 pubmed
    ..All the above results suggested that addition of some hydrophobic groups to the traditional antioxidants could form novel compounds with better properties. ..
  30. Lee H, Bae E, Han M, Kim D. Hepatoprotective effect of 20(S)-ginsenosides Rg3 and its metabolite 20(S)-ginsenoside Rh2 on tert-butyl hydroperoxide-induced liver injury. Biol Pharm Bull. 2005;28:1992-4 pubmed
    ..However, intraperitoneally administered 20(S)-ginsenoside Rg3 could not inhibit the elevation of serum ALT and AST activities. These results suggest that 20(S)-ginsenoside Rg3 a main component of RG may be a prodrug for hepatotoxicity. ..
  31. Dorsey C, Tomaras A, Actis L. Sequence and organization of pMAC, an Acinetobacter baumannii plasmid harboring genes involved in organic peroxide resistance. Plasmid. 2006;56:112-23 pubmed publisher
  32. Yang X, Zhao Y, Lv Y, Yang Y, Ruan Y. Protective effect of polysaccharide fractions from Radix A. sinensis against tert-butylhydroperoxide induced oxidative injury in murine peritoneal macrophages. J Biochem Mol Biol. 2007;40:928-35 pubmed
    ..Furthermore, we found for the first time that the bound-protein in APF3 was associated closely with the protective effects and the polysaccharide inhibited the excess NO release from t-BHP-activated macrophages to protect host cells. ..
  33. Kasai H, Kawai K. DNA methylation at the C-5 position of cytosine by methyl radicals: a possible role for epigenetic change during carcinogenesis by environmental agents. Chem Res Toxicol. 2009;22:984-9 pubmed publisher
    ..We propose here that this reaction is one of the important mechanisms of de novo DNA methylation during carcinogenesis, because methyl radicals are produced by the biotransformation of various endogenous and exogenous compounds. ..
  34. Zhou Y, Pasham V, Chatterjee S, Rotte A, Yang W, Bhandaru M, et al. Regulation of Na⁺/H⁺ Exchanger in Dendritic Cells by Akt1. Cell Physiol Biochem. 2015;36:1237-49 pubmed publisher
    ..The present observations demonstrate that Akt1 is required for the full stimulation of Na(+)/H(+) exchanger activity by LPS or oxidative stress in dendritic cells. ..
  35. Jiang S, Moriarty Craige S, Orr M, Cai J, Sternberg P, Jones D. Oxidant-induced apoptosis in human retinal pigment epithelial cells: dependence on extracellular redox state. Invest Ophthalmol Vis Sci. 2005;46:1054-61 pubmed
  36. Aronis A, Madar Z, Tirosh O. Mechanism underlying oxidative stress-mediated lipotoxicity: exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis. Free Radic Biol Med. 2005;38:1221-30 pubmed
  37. Kanupriya -, Dipti P, Sharma S, Sairam M, Ilavazhagan G, Sawhney R, et al. Flavonoids protect U-937 macrophages against tert-butylhydroperoxide induced oxidative injury. Food Chem Toxicol. 2006;44:1024-30 pubmed
    ..Epicatechin and catechin were found to be more efficient than quercetin in inhibiting tert-BOOH induced cellular damage. ..
  38. Korotkov S, Konovalova S, Brailovskaya I, Saris N. To involvement the conformation of the adenine nucleotide translocase in opening the Tl(+)-induced permeability transition pore in Ca(2+)-loaded rat liver mitochondria. Toxicol In Vitro. 2016;32:320-32 pubmed publisher
    ..Using the Tl(+)-induced MPTP model is discussed in terms finding new transition pore inhibitors and inducers among different chemical and natural compounds. ..
  39. Kweon M, Jung M, Sung H. Cytoprotective effects of heme oxygenase-1 induction by 3-O-caffeoyl-1-methylquinic acid. Free Radic Biol Med. 2004;36:40-52 pubmed
    ..Ferritin mRNA was also upregulated during all HO-1 induction by MCGA3, which might decrease iron and lower ROS levels. Consequently, the combined action of HO-1 and ferritin may protect cells from toxic tBHP-mediated necrosis. ..
  40. Okamoto K, Maruyama T, Kaji Y, Harada M, Mawatari S, Fujino T, et al. Verapamil prevents impairment in filterability of human erythrocytes exposed to oxidative stress. Jpn J Physiol. 2004;54:39-46 pubmed
  41. Krasowska A, Sigler K. Cell-protective and antioxidant activity of two groups of synthetic amphiphilic compounds--phenolics and amine N-oxides. Folia Microbiol (Praha). 2007;52:585-92 pubmed
    ..cerevisiae superoxide dismutase mutants. In contrast to their action on live cells, phenolics are less effective than N-oxides in preventing lipid peroxidation of an emulsion of lipids isolated from S. cerevisiae membranes. ..
  42. Silva C, Herdeiro R, Mathias C, Panek A, Silveira C, Rodrigues V, et al. Evaluation of antioxidant activity of Brazilian plants. Pharmacol Res. 2005;52:229-33 pubmed
    ..Interestingly, the ethanol extract of G. biloba were not effective for yeast cell protection, reinforcing the antioxidant potential of these extracts. ..
  43. Lee K, Choi J, Hwang Y, Chung Y, Jeong H. Protective effect of caffeic acid phenethyl ester on tert-butyl hydroperoxide-induced oxidative hepatotoxicity and DNA damage. Food Chem Toxicol. 2008;46:2445-50 pubmed publisher
    ..Taken together, these results suggest that the protective effects of CAPE against t-BHP-induced hepatotoxicity may, at least in part, be due to its ability to scavenge ROS and protect DNA from oxidative stress-induced damage. ..
  44. Li H, Jubelirer S, Garcia Costas A, Frigaard N, Bryant D. Multiple antioxidant proteins protect Chlorobaculum tepidum against oxygen and reactive oxygen species. Arch Microbiol. 2009;191:853-67 pubmed publisher
    ..Reverse-transcriptase polymerase chain reaction studies showed that the genes with functions in oxidative stress protection were constitutively transcribed under anoxic growth conditions...
  45. Mahesh D, Satheesh V, Kumar S, Punniyamurthy T. Copper(II)-Catalyzed Oxidative Coupling of Anilines, Methyl Arenes, and TMSN3 via C(sp3/sp2)-H Functionalization and C-N Bond Formation. Org Lett. 2017;: pubmed publisher
    ..The selectivity and multiple C-H functionalization of the simple substrates are significant practical features...
  46. Voloboueva L, Liu J, Suh J, Ames B, Miller S. (R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage. Invest Ophthalmol Vis Sci. 2005;46:4302-10 pubmed
    ..The present study suggests that the protective effect of LA involves multiple pathways and that LA could be effective against age-associated increase in oxidative stress and mitochondrial dysfunction in RPE cells. ..
  47. Chung J, Lee H, Chung H, Yoon T, Kim H. Salicylideneamino-2-thiophenol inhibits inflammatory mediator genes (RANTES, MCP-1, IL-8 and HIF-1alpha) expression induced by tert-butyl hydroperoxide via MAPK pathways in rat peritoneal macrophages. Biotechnol Lett. 2008;30:1553-8 pubmed publisher
  48. Chang B, Lee D, Lee J, Kim Y, Cho H, Kim S. Protective activity of kudzu (Pueraria thunbergiana) vine on chemically-induced hepatotoxicity: in vitro and in vivo studies. BMC Complement Altern Med. 2016;16:39 pubmed publisher
    ..05). The kudzu vine is potentially highly beneficial in treating liver damage, as it scavenges reactive free radicals and boosts the endogenous antioxidant system. ..
  49. Langston W, Circu M, Aw T. Insulin stimulation of gamma-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: influence of low glucose. Free Radic Biol Med. 2008;45:1591-9 pubmed publisher
  50. Ogasawara Y, Namai T, Togawa T, Ishii K. Formation of albumin dimers induced by exposure to peroxides in human plasma: a possible biomarker for oxidative stress. Biochem Biophys Res Commun. 2006;340:353-8 pubmed
    ..The present results indicate that albumin dimers are oxidative products derived from peroxides, and that their presence in plasma might be a marker of oxidative stress as secondary metabolites of peroxidation. ..
  51. Cipak A, Hasslacher M, Tehlivets O, Collinson E, Zivkovic M, Matijevic T, et al. Saccharomyces cerevisiae strain expressing a plant fatty acid desaturase produces polyunsaturated fatty acids and is susceptible to oxidative stress induced by lipid peroxidation. Free Radic Biol Med. 2006;40:897-906 pubmed
    ..Its potential to investigate the molecular basis of responses to oxidative stress, in particular the involvement of reactive aldehydes derived from fatty acid peroxidation, especially 4-hydroxy-2-nonenal, will be addressed. ..
  52. Charitha L, Adinarayana M. Reaction of substituted pyrimidines with photochemically generated t-BuO* radicals. Indian J Biochem Biophys. 2005;42:386-90 pubmed
    ..The pyrimidine radical further reacts with t-BuO* radical to give the final product. This study predicts the probable transient pyrimidine radicals. ..
  53. Wagner K, Reichhold S, Koschutnig K, Chériot S, Billaud C. The potential antimutagenic and antioxidant effects of Maillard reaction products used as "natural antibrowning" agents. Mol Nutr Food Res. 2007;51:496-504 pubmed
  54. Kim W, Park B, Kim H, Park J, Kim K, Choi J, et al. Evidence supporting antioxidant action of adipose-derived stem cells: protection of human dermal fibroblasts from oxidative stress. J Dermatol Sci. 2008;49:133-42 pubmed
    ..Therefore, ADSCs and ADSC-CM are good candidates for control and prevention of skin damage from free radicals in various skin conditions. ..
  55. Lee B, Johng H, Lim J, Jeong J, Baik K, Nam T, et al. Effects of extremely low frequency magnetic field on the antioxidant defense system in mouse brain: a chemiluminescence study. J Photochem Photobiol B. 2004;73:43-8 pubmed
    ..Further studies are needed to identify the kind of ROS generated by the exposure to 60 Hz, MF and elucidate how MF can affect biological system in connection with oxidative stress. ..
  56. Lin M, Yang S, Huang M, Wu S. Stimulatory actions of caffeic acid phenethyl ester, a known inhibitor of NF-kappaB activation, on Ca2+-activated K+ current in pituitary GH3 cells. J Biol Chem. 2004;279:26885-92 pubmed
    ..Caution has to be used in attributing its response in the activation of NF-kappaB. ..
  57. Allani P, Sum T, Bhansali S, Mukherjee S, Sonee M. A comparative study of the effect of oxidative stress on the cytoskeleton in human cortical neurons. Toxicol Appl Pharmacol. 2004;196:29-36 pubmed
  58. Hwang J, Wang C, Chou F, Tseng T, Hsieh Y, Hsu J, et al. Protective effect of baicalin on tert-butyl hydroperoxide-induced rat hepatotoxicity. Arch Toxicol. 2005;79:102-9 pubmed
    ..Based on the results described above, we speculate that baicalin may play a chemopreventive role via reducing oxidative stress in living systems. ..
  59. Huang H, Chen H, Xu H, Gibson G. Modification of endoplasmic reticulum Ca2+ stores by select oxidants produces changes reminiscent of those in cells from patients with Alzheimer disease. Free Radic Biol Med. 2005;39:979-89 pubmed
    ..Thus, these results are consistent with the hypothesis that abnormalities in selective cellular ROS cause AD-related changes in intracellular calcium regulation. ..
  60. Rota C, Tomasi A, Palozza P, Manfredini S, Iannone A. Antioxidant effect of FeAOX-6 on free radical species produced during iron catalyzed breakdown of tert-butyl hydroperoxide. Free Radic Res. 2006;40:141-6 pubmed
    ..Lycopene is able to quench alkoxyl radical, while it has no effect on peroxyl radical, showing a different antioxidant activity compared to other carotenoids, such as beta-carotene and lutein. ..
  61. Thompson J, Thomas P, Schuller K. Purification and properties of a glutathione peroxidase from Southern bluefin tuna (Thunnus maccoyii) liver. Comp Biochem Physiol B Biochem Mol Biol. 2006;144:86-93 pubmed
    ..The pH optimum of the purified enzyme was pH 8.0. Immunoblotting experiments with polyclonal antibodies, raised against a recombinant human GPX, provided further evidence that the purified SBT enzyme is a genuine GPX. ..
  62. Banerjee D, Markley A, Yano T, Ghosh A, Berget P, Minkley E, et al. "Green" oxidation catalysis for rapid deactivation of bacterial spores. Angew Chem Int Ed Engl. 2006;45:3974-7 pubmed
  63. Velu C, Niture S, Doneanu C, Pattabiraman N, Srivenugopal K. Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress. Biochemistry. 2007;46:7765-80 pubmed
  64. Martin M, Ramos S, Mateos R, Granado Serrano A, Izquierdo Pulido M, Bravo L, et al. Protection of human HepG2 cells against oxidative stress by cocoa phenolic extract. J Agric Food Chem. 2008;56:7765-72 pubmed publisher
    ..These results show that treatment of HepG2 in culture with CPE (within the physiological range of concentrations) confers a significant protection against oxidation to the cells. ..
  65. Chen H, Zhou L, Lin C, Beattie M, Liu J, Zirkin B. Effect of glutathione redox state on Leydig cell susceptibility to acute oxidative stress. Mol Cell Endocrinol. 2010;323:147-54 pubmed publisher
  66. Bond C, Patel P, Crouch L, Tetlow N, Day T, Abu Hayyeh S, et al. Astroglia up-regulate transcription and secretion of 'readthrough' acetylcholinesterase following oxidative stress. Eur J Neurosci. 2006;24:381-6 pubmed
    ..Neurotrauma 6, 365-76]. The data presented here suggest that glial cells may be key chemical intermediaries in such situations and, perhaps more generally in pathological conditions involving oxidative stress, such as neurodegeneration. ..
  67. Rasbach K, Schnellmann R. Signaling of mitochondrial biogenesis following oxidant injury. J Biol Chem. 2007;282:2355-62 pubmed
    ..In contrast, although Akt was activated following oxidant injury, it did not play a role in PGC-1alpha expression. We suggest that mitochondrial biogenesis following oxidant injury is mediated by p38 and EGFR activation of PGC-1alpha. ..
  68. Cuello S, Ramos S, Mateos R, Martin M, Madrid Y, Cámara C, et al. Selenium methylselenocysteine protects human hepatoma HepG2 cells against oxidative stress induced by tert-butyl hydroperoxide. Anal Bioanal Chem. 2007;389:2167-78 pubmed
    ..The results show that treatment of HepG2 cells with concentrations of Se-MeSeCys in the nanomolar to micromolar range confers a significant protection against an oxidative insult. ..
  69. Kruszewski M, Iwaneńko T, Bartłomiejczyk T, Woliński J, Starzyński R, Gralak M, et al. Hepatic iron content corresponds with the susceptibility of lymphocytes to oxidative stress in neonatal pigs. Mutat Res. 2008;657:146-9 pubmed publisher
    ..Our data show that decreased hepatic iron content corresponds with decreased susceptibility of blood lymphocytes to oxidative stressors. ..
  70. Lu Z, Nie G, Li Y, Soe Lin S, Tao Y, Cao Y, et al. Overexpression of mitochondrial ferritin sensitizes cells to oxidative stress via an iron-mediated mechanism. Antioxid Redox Signal. 2009;11:1791-803 pubmed publisher
  71. Pandey K, Rizvi S. Protective effect of resveratrol on formation of membrane protein carbonyls and lipid peroxidation in erythrocytes subjected to oxidative stress. Appl Physiol Nutr Metab. 2009;34:1093-7 pubmed publisher
    ..The effect of resveratrol was concentration and time-dependent. Our findings help to explain some of the beneficial effects of resveratrol. ..
  72. Silva J, Sardao V, Coutinho O, Oliveira P, Olveira P. Nitrogen compounds prevent h9c2 myoblast oxidative stress-induced mitochondrial dysfunction and cell death. Cardiovasc Toxicol. 2010;10:51-65 pubmed publisher
    ..Data obtained indicates that some of the test compounds may clearly prove valuable in a clinical context by diminishing cardiac injury associated to oxidative stress without any toxicity. ..
  73. Mourvaki E, Cardinali R, Dal Bosco A, Castellini C. In vitro antioxidant activity of the prostatic secretory granules in rabbit semen after exposure to organic peroxides. Reprod Biol Endocrinol. 2010;8:16 pubmed publisher
    ..This mechanism could be in part involved in the inhibition of sperm capacitation by the granules. ..
  74. Dzyuba S, Klibanov A. Asymmetric thiosulfinations catalyzed by bovine serum albumin and horseradish peroxidase. Biotechnol Lett. 2003;25:1961-5 pubmed
    ..The rates of HRP-catalyzed thiosulfination in methanol were several times faster than in water but the enzyme was less stereoselective...
  75. Raman C, McAllister S, Rizvi G, Patel S, Moore D, Abood M. Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid. Amyotroph Lateral Scler Other Motor Neuron Disord. 2004;5:33-9 pubmed
    ..These cellular mechanisms may underlie the presumed neuroprotective effect in ALS. As Delta(9)-THC is well tolerated, it and other cannabinoids may prove to be novel therapeutic targets for the treatment of ALS. ..
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    ..If the melanosome, an insoluble particle, performs a cytoprotective function within cells, its effects may be limited to the local environment of the organelle and undetectable by conventional methods. ..
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    ..This is the first report validating the use of a mammalian renal cell culture model to study the toxicological effects of compensatory renal cellular hypertrophy. ..
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    ..On the other hand, phytoncide solutions also suppressed the excess MMP-1 irradiated UVA in a concentration-dependent manner. These effects of G-type solution were superior to those of other types solutions. ..
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    ..Our results suggested that COX activators such as t-BHP and H2O2, which are located in cytosol, are essential for the activation of COX in aged lung. ..
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    ..Results show that lc treated cells exhibited a significant decrease in the number of oxidative induced single-strand breaks and chromosomal aberrations. ..
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    ..Our results are in support of the protective role against oxidative stress ascribed to MTs and provide evidence that MT2A expression may be a beneficial downstream adaptive response in complex I-deficient cells. ..
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    ..While further studies are required to clarify the molecular events involved, these results confirm that calpain activation and the ER are important related players in chemically induced renal cell damage...
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    ..0125 microM. This chromatographic method was successfully applied to investigating the in vitro antioxidant effect of vitexin-4''-O-glucoside. Vitexin-4''-O-glucoside (120 M) protected ECV304 cells from peroxidation induced by TBHP. ..
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