iodides

Summary

Summary: Inorganic binary compounds of iodine or the I- ion.

Top Publications

  1. Abendroth J, Gardberg A, Robinson J, Christensen J, Staker B, Myler P, et al. SAD phasing using iodide ions in a high-throughput structural genomics environment. J Struct Funct Genomics. 2011;12:83-95 pubmed publisher
    ..These cases highlight the straightforward and powerful method of iodide ion SAD phasing in a high-throughput structural genomics environment...
  2. Ugajin K, Takahashi E, Yamasaki R, Mutoh Y, Kasama T, Saito S. Synthesis of [2]rotaxanes by the copper-mediated threading reactions of aryl iodides with alkynes. Org Lett. 2013;15:2684-7 pubmed publisher
    ..Thus, [2]rotaxanes were prepared by reactions between terminal alkynes and aryl iodides in the presence of the macrocyclic copper complex...
  3. Nguyen J, D Amato E, Narayanam J, Stephenson C. Engaging unactivated alkyl, alkenyl and aryl iodides in visible-light-mediated free radical reactions. Nat Chem. 2012;4:854-9 pubmed
    ..photocatalysts such as fac-Ir(ppy)3 can be utilized to form radicals from unactivated alkyl, alkenyl and aryl iodides. The generated radicals undergo reduction via hydrogen atom abstraction or reductive cyclization...
  4. Fier P, Hartwig J. Copper-mediated difluoromethylation of aryl and vinyl iodides. J Am Chem Soc. 2012;134:5524-7 pubmed publisher
    ..We report a straightforward method for the cross-coupling of aryl and vinyl iodides with a difluoromethyl group generated from readily available reagents to form difluoromethylarenes and ..
  5. Kim H, Lee C, Im J, Lee K, Moehl T, Marchioro A, et al. Lead iodide perovskite sensitized all-solid-state submicron thin film mesoscopic solar cell with efficiency exceeding 9%. Sci Rep. 2012;2:591 pubmed publisher
    ..The use of a solid hole conductor dramatically improved the device stability compared to (CH(3)NH(3))PbI(3) -sensitized liquid junction cells...
  6. Fier P, Hartwig J. Copper-mediated fluorination of aryl iodides. J Am Chem Soc. 2012;134:10795-8 pubmed publisher
    ..We report the conversion of a diverse set of aryl iodides to the corresponding aryl fluorides. This reaction occurs with a cationic copper reagent and silver fluoride...
  7. Rivolta C, Esperante S, Gruñeiro Papendieck L, Chiesa A, Moya C, Domené S, et al. Five novel inactivating mutations in the thyroid peroxidase gene responsible for congenital goiter and iodide organification defect. Hum Mutat. 2003;22:259 pubmed
    ..C808R change. In addition, the previously reported GGCC duplication in exon 8 (c.1186_1187insGGCC; p.R396fsX472) was also detected in two affected individuals, one of whom was a compound heterozygous (p.R396fsX472/p.V433M)...
  8. Bakker B, Bikker H, Vulsma T, de Randamie J, Wiedijk B, de Vijlder J. Two decades of screening for congenital hypothyroidism in The Netherlands: TPO gene mutations in total iodide organification defects (an update). J Clin Endocrinol Metab. 2000;85:3708-12 pubmed
    ..Mutations in the TPO gene result in total iodide organification defects...
  9. Liang J, Chen C, Huang S, Ho T, Hsiang C, Ding H, et al. A novel loss-of-function deletion in sodium/iodide symporter gene in follicular thyroid adenoma. Cancer Lett. 2005;230:65-71 pubmed
    ..Our data demonstrated that the exon 6 deletion causes an iodide-trapping defect...

More Information

Publications62

  1. Riedel C, Levy O, Carrasco N. Post-transcriptional regulation of the sodium/iodide symporter by thyrotropin. J Biol Chem. 2001;276:21458-63 pubmed
  2. Matsuda A, Kosugi S. A homozygous missense mutation of the sodium/iodide symporter gene causing iodide transport defect. J Clin Endocrinol Metab. 1997;82:3966-71 pubmed
    ..Northern analysis of thyroid ribonucleic acid revealed that NIS messenger ribonucleic acid level was markedly increased (> 100-fold) compared with that in the normal thyroid, suggesting possible compensation by overexpression...
  3. Yogavel M, Khan S, Bhatt T, Sharma A. Structure of D-tyrosyl-tRNATyr deacylase using home-source Cu Kalpha and moderate-quality iodide-SAD data: structural polymorphism and HEPES-bound enzyme states. Acta Crystallogr D Biol Crystallogr. 2010;66:584-92 pubmed publisher
    ..By tracking the changes in PfDTD unit cells, it was possible to map conformational differences within PfDTD that may be of significance for enzyme activity...
  4. Furuya F, Shimura H, Miyazaki A, Taki K, Ohta K, Haraguchi K, et al. Adenovirus-mediated transfer of thyroid transcription factor-1 induces radioiodide organification and retention in thyroid cancer cells. Endocrinology. 2004;145:5397-405 pubmed
    ..These results indicate that AdTTF-1 specifically induces iodide organification and retards iodide efflux in thyroid cancer cells in vitro and in vivo...
  5. Niu D, Hwang B, Chu Y, Liao C, Wang P, Lin C. High prevalence of a novel mutation (2268 insT) of the thyroid peroxidase gene in Taiwanese patients with total iodide organification defect, and evidence for a founder effect. J Clin Endocrinol Metab. 2002;87:4208-12 pubmed
    ..00 and 0.02, respectively (P < 0.0001). This indicates that this common novel mutation among Taiwanese patients with TIOD is due to a founder effect...
  6. Kwong F, Buchwald S. A general, efficient, and inexpensive catalyst system for the coupling of aryl iodides and thiols. Org Lett. 2002;4:3517-20 pubmed
    ..This method is particularly noteworthy given its experimental simplicity, high generality, and exceptional level of functional group toleration and the low cost of the catalyst system. [reaction: see text]..
  7. Tran N, Valentin Blasini L, Blount B, McCuistion C, Fenton M, Gin E, et al. Thyroid-stimulating hormone increases active transport of perchlorate into thyroid cells. Am J Physiol Endocrinol Metab. 2008;294:E802-6 pubmed publisher
    ..Even the highest concentration of perchlorate (100 microM) did not inhibit cell proliferation after 72 h of incubation. In conclusion, perchlorate is actively transported into thyroid cells and does not inhibit cell proliferation...
  8. Merrill E, Clewell R, Gearhart J, Robinson P, Sterner T, Yu K, et al. PBPK predictions of perchlorate distribution and its effect on thyroid uptake of radioiodide in the male rat. Toxicol Sci. 2003;73:256-69 pubmed
    ..2003). Because the model successfully predicts perchlorate's interaction with iodide, it provides a sound basis for future incorporation of the complex hypothalamic-pituitary-thyroid feedback system...
  9. McLanahan E, Campbell J, Ferguson D, Harmon B, Hedge J, Crofton K, et al. Low-dose effects of ammonium perchlorate on the hypothalamic-pituitary-thyroid axis of adult male rats pretreated with PCB126. Toxicol Sci. 2007;97:308-17 pubmed
    ..At relatively low doses, at or near the no-observed-effect-level for PCB126 and ClO(4)(-), no interactions between the chemicals occur...
  10. Valentin Blasini L, Blount B, Delinsky A. Quantification of iodide and sodium-iodide symporter inhibitors in human urine using ion chromatography tandem mass spectrometry. J Chromatogr A. 2007;1155:40-6 pubmed
    ..Measurement of these four toxicologically-related analytes in one assay will provide useful information for assessing potential linkage between exposure and health effects...
  11. Anorlu R, Ola E, Abudu O. Low cost methods for secondary prevention of cervical cancer in developing countries. Niger Postgrad Med J. 2007;14:242-6 pubmed
    ..This is due to the unavailability of organised screening programmes. To address this problem, effective and practical alternatives to cytology are being investigated in many studies...
  12. De La Vieja A, Ginter C, Carrasco N. The Q267E mutation in the sodium/iodide symporter (NIS) causes congenital iodide transport defect (ITD) by decreasing the NIS turnover number. J Cell Sci. 2004;117:677-87 pubmed
  13. Kirk A, Martinelango P, Tian K, Dutta A, Smith E, Dasgupta P. Perchlorate and iodide in dairy and breast milk. Environ Sci Technol. 2005;39:2011-7 pubmed
    ..On the basis of limited available data, iodide levels in breast milk may be significantly lower than it was two decades ago. Recommended iodine intake by pregnant and lactating women may need to be revised upward...
  14. Lam S, Gervay Hague J. Solution- and solid-phase oligosaccharide synthesis using glucosyl iodides: a comparative study. Carbohydr Res. 2002;337:1953-65 pubmed
    ..gt; 6)-tetrakis-(2,3,4-tri-O-benzyl-alpha-D-glucopyranosyl-(1 --> 6))-2,3,4-tri-O-benzyl-1-thio-alpha-D-glucopyranoside) that was constructed from dimer donor iodides in a two-plus-two and a two-plus-four fashion.
  15. Meloncelli P, Martin A, Lowary T. Glycosyl iodides. History and recent advances. Carbohydr Res. 2009;344:1110-22 pubmed publisher
    The use of glycosyl iodides as an effective method for the preparation of glycosides has had a recent resurgence in carbohydrate chemistry, despite its early roots in which these species were believed to be of limited use...
  16. McLanahan E, Andersen M, Campbell J, Fisher J. Competitive inhibition of thyroidal uptake of dietary iodide by perchlorate does not describe perturbations in rat serum total T4 and TSH. Environ Health Perspect. 2009;117:731-8 pubmed publisher
    ..ClO4(-) competitively inhibits iodide uptake into the thyroid at the sodium/iodide symporter and disrupts hypothalamic-pituitary-thyroid (HPT) axis homeostasis in rodents...
  17. Kosugi S, Bhayana S, Dean H. A novel mutation in the sodium/iodide symporter gene in the largest family with iodide transport defect. J Clin Endocrinol Metab. 1999;84:3248-53 pubmed
  18. Bhatla N, Gulati A, Mathur S, Rani S, Anand K, Muwonge R, et al. Evaluation of cervical screening in rural North India. Int J Gynaecol Obstet. 2009;105:145-9 pubmed publisher
    ..To assess the accuracy of cervical screening with visual inspection and cytology testing, and the cure rate of cervical intraepithelial neoplasia (CIN) after treatment, in a rural population in North India...
  19. Yogavel M, Gill J, Mishra P, Sharma A. SAD phasing of a structure based on cocrystallized iodides using an in-house Cu Kalpha X-ray source: effects of data redundancy and completeness on structure solution. Acta Crystallogr D Biol Crystallogr. 2007;63:931-4 pubmed
    ..Cocrystallization of proteins with halide salts such as ammonium iodide in combination with copper-anode X-ray radiation can therefore serve as a powerful and easy avenue for structure solution...
  20. Kirk A, Dyke J, Martin C, Dasgupta P. Temporal patterns in perchlorate, thiocyanate, and iodide excretion in human milk. Environ Health Perspect. 2007;115:182-6 pubmed
    ..Perchlorate is a common contaminant of water, food, and human milk. Although it is known that iodide undergoes significant diurnal variations in serum and urinary excretion, less is known about diurnal variations of milk iodide levels...
  21. Mühlbauer M, da Silva A, Marassi M, Lourenço A, Ferreira A, de Carvalho D. Retinoic acid modulation of thyroid dual oxidase activity in rats and its impact on thyroid iodine organification. J Endocrinol. 2010;205:271-7 pubmed publisher
  22. Schmutzler C, Winzer R, Meissner Weigl J, Kohrle J. Retinoic acid increases sodium/iodide symporter mRNA levels in human thyroid cancer cell lines and suppresses expression of functional symporter in nontransformed FRTL-5 rat thyroid cells. Biochem Biophys Res Commun. 1997;240:832-8 pubmed
  23. Markou K, Georgopoulos N, Kyriazopoulou V, Vagenakis A. Iodine-Induced hypothyroidism. Thyroid. 2001;11:501-10 pubmed
    ..radioimmunoassay (RAI), surgery or antithyroid drugs, the escape from the inhibitory effect of large doses of iodides is not achieved and clinical or subclinical hypothyroidism ensues...
  24. Dohan O, De La Vieja A, Paroder V, Riedel C, Artani M, Reed M, et al. The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. Endocr Rev. 2003;24:48-77 pubmed
    ..Most dramatically, the discovery of endogenous NIS expression in more than 80% of human breast cancer samples has raised the possibility that radioiodide may be a valuable novel tool in breast cancer diagnosis and treatment...
  25. Pohlenz J, Medeiros Neto G, Gross J, Silveiro S, Knobel M, Refetoff S. Hypothyroidism in a Brazilian kindred due to iodide trapping defect caused by a homozygous mutation in the sodium/iodide symporter gene. Biochem Biophys Res Commun. 1997;240:488-91 pubmed
    ..While the homozygous mutant NIS-272X causes congenital hypothyroidism, expression of one normal allele in the heterozygote (C272X) is sufficient to maintain active thyroidal I- uptake and function...
  26. Clewell R, Merrill E, Narayanan L, Gearhart J, Robinson P. Evidence for competitive inhibition of iodide uptake by perchlorate and translocation of perchlorate into the thyroid. Int J Toxicol. 2004;23:17-23 pubmed
    ..We believe this description of perchlorate's kinetic behavior should serve as the foundation for predictive physiologically based pharmacokinetic (PBPK) models and as a working hypothesis for further experimental exploration...
  27. Katagiri A, Kaneko K, Konishi K, Ito H, Kushima M, Mitamura K. Lugol staining pattern in background epithelium of patients with esophageal squamous cell carcinoma. Hepatogastroenterology. 2004;51:713-7 pubmed
    ..Squamous cell carcinoma of the esophagus often arises in the setting of chronic esophagitis. We investigated whether chronic esophagitis was associated with carcinogenesis in the esophageal squamous epithelium...
  28. Johnson D. Alkyldimethylaminoethyl ester iodides for improved analysis of fatty acids by electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2000;14:2019-24 pubmed
    The development of a new class of derivatives, the alkyldimethylaminoethyl ester iodides, for the analysis of fatty acids by electrospray ionization tandem mass spectrometry is described...
  29. Sangwa Lugoma G, Mahmud S, Nasr S, Liaras J, Kayembe P, Tozin R, et al. Visual inspection as a cervical cancer screening method in a primary health care setting in Africa. Int J Cancer. 2006;119:1389-95 pubmed
    ..Given their lower cost and easy deployment, visual inspection methods merit further assessment as cervical cancer screening methods for low-resource countries...
  30. Schröder van der Elst J, van der Heide D, Romijn J, Smit J. Differential effects of natural flavonoids on growth and iodide content in a human Na*/I- symporter-transfected follicular thyroid carcinoma cell line. Eur J Endocrinol. 2004;150:557-64 pubmed
    ..We have studied the role of flavonoids on the iodide transport and the growth of the human follicular thyroid cancer cell line (FTC133) which was stably transfected with the human Na(+)/I(-) symporter (hNIS)...
  31. Nascimento A, Guedes D, Santos C, Knobel M, Rubio I, Medeiros Neto G. Thyroperoxidase gene mutations in congenital goitrous hypothyroidism with total and partial iodide organification defect. Thyroid. 2003;13:1145-51 pubmed
    ..It is conceivable that these TPO gene sequence alterations may partially affect the functional state of the translated protein or affect its transport to the apical membrane...
  32. Sarian L, Derchain S, Naud P, Roteli Martins C, Longatto Filho A, Tatti S, et al. Evaluation of visual inspection with acetic acid (VIA), Lugol's iodine (VILI), cervical cytology and HPV testing as cervical screening tools in Latin America. This report refers to partial results from the LAMS (Latin AMerican Screening) study. J Med Screen. 2005;12:142-9 pubmed
  33. Dauter Z, Dauter M, Rajashankar K. Novel approach to phasing proteins: derivatization by short cryo-soaking with halides. Acta Crystallogr D Biol Crystallogr. 2000;56:232-7 pubmed
    ..their anomalous scattering signal: bromides using multiwavelength anomalous dispersion (MAD) and bromides and/or iodides using single-wavelength anomalous dispersion (SAD) or single isomorphous replacement with anomalous scattering (..
  34. Arturi F, Lacroix L, Presta I, Scarpelli D, Caillou B, Schlumberger M, et al. Regulation by human chorionic gonadotropin of sodium/iodide symporter gene expression in the JAr human choriocarcinoma cell line. Endocrinology. 2002;143:2216-20 pubmed
  35. Yoshida A, Taniguchi S, Hisatome I, Royaux I, Green E, Kohn L, et al. Pendrin is an iodide-specific apical porter responsible for iodide efflux from thyroid cells. J Clin Endocrinol Metab. 2002;87:3356-61 pubmed
  36. Umeki K, Kotani T, Kawano J, Suganuma T, Yamamoto I, Aratake Y, et al. Two novel missense mutations in the thyroid peroxidase gene, R665W and G771R, result in a localization defect and cause congenital hypothyroidism. Eur J Endocrinol. 2002;146:491-8 pubmed
    ..To determine the frequency and pattern of TPO abnormalities, we have been screening TPO genes of patients with congenital goitrous hypothyroidism...
  37. Carvalho D, Ferreira A. The importance of sodium/iodide symporter (NIS) for thyroid cancer management. Arq Bras Endocrinol Metabol. 2007;51:672-82 pubmed
    ..In conclusion, NIS gene cloning led to an important development in the field of thyroid pathophysiology, and has also been fundamental to extend the use of radioiodine for the management of non-thyroid tumors...
  38. Eng P, Cardona G, Fang S, Previti M, Alex S, Carrasco N, et al. Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. Endocrinology. 1999;140:3404-10 pubmed
    ..The observed decrease in TPO mRNA may contribute to the iodine-induced hypothyroidism that is common in patients with Hashimoto's thyroiditis...
  39. Dauter M, Dauter Z. Phase determination using halide ions. Methods Mol Biol. 2007;364:149-58 pubmed
    A short soak of protein crystals in cryosolution containing bromides or iodides leads to incorporation of these ions into the ordered solvent shell around the protein surface...
  40. Scinicariello F, Murray H, Smith L, Wilbur S, Fowler B. Genetic factors that might lead to different responses in individuals exposed to perchlorate. Environ Health Perspect. 2005;113:1479-84 pubmed
    ..We conclude that future studies linking human disease and environmental perchlorate exposure should consider the genetic makeup of the participants, actual perchlorate exposure levels, and individual iodine intake/excretion levels...
  41. Filetti S, Bidart J, Arturi F, Caillou B, Russo D, Schlumberger M. Sodium/iodide symporter: a key transport system in thyroid cancer cell metabolism. Eur J Endocrinol. 1999;141:443-57 pubmed
    ..New strategies, based on manipulation of NIS expression, to obtain NIS gene reactivation or for use as NIS gene therapy in the treatment of radiosensitive cancer, are also being investigated...
  42. Wang M, Anghel A, Marsan B, Cevey Ha N, Pootrakulchote N, Zakeeruddin S, et al. CoS supersedes Pt as efficient electrocatalyst for triiodide reduction in dye-sensitized solar cells. J Am Chem Soc. 2009;131:15976-7 pubmed publisher
    ..This is expected to have an important practical consequence on the production of flexible low-cost and lightweight thin film DSC devices based on the plastic matrix...
  43. Wu S, Ho T, Liang J, Hsiang C. Histidine residue at position 226 is critical for iodide uptake activity of human sodium/iodide symporter. J Endocrinol. 2008;199:213-9 pubmed publisher
    ..In conclusion, our data first identified the involvement of extracellular charged amino acid residue in the iodide uptake ability of SLC5A5...
  44. Yogavel M, Gill J, Sharma A. Iodide-SAD, SIR and SIRAS phasing for structure solution of a nucleosome assembly protein. Acta Crystallogr D Biol Crystallogr. 2009;65:618-22 pubmed publisher
    ..5 A resolution bin, the data were sufficient to determine the structure by SAD/SIR/SIRAS methods using the soaked iodides. Previously, structure solution had failed with both molecular-replacement and selenomethionine-derivatization ..
  45. Wolff J, Chaikoff I. Plasma inorganic iodide as a homeostatic regulator of thyroid function. J Biol Chem. 1948;174:555-64 pubmed
  46. Arbyn M, Sankaranarayanan R, Muwonge R, Keita N, Dolo A, Mbalawa C, et al. Pooled analysis of the accuracy of five cervical cancer screening tests assessed in eleven studies in Africa and India. Int J Cancer. 2008;123:153-60 pubmed publisher
    ..Gold standard verification error could also explain the surprisingly low sensitivity of HC2, which contrasts with findings from other studies...
  47. Tonacchera M, Pinchera A, Dimida A, Ferrarini E, Agretti P, Vitti P, et al. Relative potencies and additivity of perchlorate, thiocyanate, nitrate, and iodide on the inhibition of radioactive iodide uptake by the human sodium iodide symporter. Thyroid. 2004;14:1012-9 pubmed
  48. Kosugi S, Okamoto H, Tamada A, Sanchez Franco F. A novel peculiar mutation in the sodium/iodide symporter gene in spanish siblings with iodide transport defect. J Clin Endocrinol Metab. 2002;87:3830-6 pubmed
    ..Further, the mutant NIS protein was synthesized, but not properly expressed, on the cell surface, but was mostly accumulated in the cytoplasm, suggesting impaired targeting to the plasma membrane...
  49. Fernández Rodríguez M, Hartwig J. A general, efficient, and functional-group-tolerant catalyst system for the palladium-catalyzed thioetherification of aryl bromides and iodides. J Org Chem. 2009;74:1663-72 pubmed publisher
    The cross-coupling reaction of aryl bromides and iodides with aliphatic and aromatic thiols catalyzed by palladium complexes of the bisphosphine ligand CyPF-tBu (1) is reported...
  50. Wu J, Shu S, Yang C, Lee C, Tsai F. Mutation analysis of thyroid peroxidase gene in Chinese patients with total iodide organification defect: identification of five novel mutations. J Endocrinol. 2002;172:627-35 pubmed
    ..All five TIOD patients investigated in this study were compound heterozygous. The method presented in this study could be used for carrier assessment and mutation analysis of newly identified TIOD patients...
  51. Reed Tsur M, De La Vieja A, Ginter C, Carrasco N. Molecular characterization of V59E NIS, a Na+/I- symporter mutant that causes congenital I- transport defect. Endocrinology. 2008;149:3077-84 pubmed publisher
    ..This result suggests that the region that contains V59 may be involved in intramembrane helix-helix interactions during the transport cycle without being in direct contact with the substrates...
  52. McLanahan E, Andersen M, Fisher J. A biologically based dose-response model for dietary iodide and the hypothalamic-pituitary-thyroid axis in the adult rat: evaluation of iodide deficiency. Toxicol Sci. 2008;102:241-53 pubmed publisher
    ..To support continued development of this model, future studies should include time course data after perturbation of the HPT axis to capture changes in endogenous iodide, serum TSH, T(4), and T(3)...
  53. Bhatla N, Mukhopadhyay A, Joshi S, Kumar A, Kriplani A, Pandey R, et al. Visual inspection for cervical cancer screening: evaluation by doctor versus paramedical worker. Indian J Cancer. 2004;41:32-6 pubmed
    ..In the absence of an effective cervical cancer screening programme, efforts are being made to explore the feasibility of using the existing infrastructure to develop effective low-cost screening methods...