arsenites

Summary

Summary: Inorganic salts or organic esters of arsenious acid.

Top Publications

  1. Zhao F, Severson P, Pacheco S, Futscher B, Klimecki W. Arsenic exposure induces the Warburg effect in cultured human cells. Toxicol Appl Pharmacol. 2013;271:72-7 pubmed publisher
    ..Arsenite-induced alteration of energy production in human cells represents the type of fundamental perturbation that could extend to many tissue targets and diseases. ..
  2. Kang Y, Bothner B, Rensing C, McDermott T. Involvement of RpoN in regulating bacterial arsenite oxidation. Appl Environ Microbiol. 2012;78:5638-45 pubmed publisher
  3. Marchal M, Briandet R, Halter D, Koechler S, DuBow M, Lett M, et al. Subinhibitory arsenite concentrations lead to population dispersal in Thiomonas sp. PLoS ONE. 2011;6:e23181 pubmed publisher
    ..Addressing this complex bacterial response to As(III) stress, which might be used by other microorganisms under various adverse conditions, may be essential to understand how Thiomonas strains persist in extreme environments...
  4. Bu N, Wang H, Hao W, Liu X, Xu S, Wu B, et al. Generation of thioarsenicals is dependent on the enterohepatic circulation in rats. Metallomics. 2011;3:1064-73 pubmed publisher
  5. Heinrich Salmeron A, Cordi A, Brochier Armanet C, Halter D, Pagnout C, Abbaszadeh Fard E, et al. Unsuspected diversity of arsenite-oxidizing bacteria as revealed by widespread distribution of the aoxB gene in prokaryotes. Appl Environ Microbiol. 2011;77:4685-92 pubmed publisher
    ..An exhaustive analysis of AoxB sequences from this study and from public databases shows that horizontal gene transfer has likely played a role in the spreading of aoxB in prokaryotic communities...
  6. Zhao R, Hou Y, Zhang Q, Woods C, Xue P, Fu J, et al. Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes. Environ Health Perspect. 2012;120:583-9 pubmed publisher
    ..Human exposure to inorganic arsenic, a potent oxidative stressor, causes various dermal disorders, including hyperkeratosis and skin cancer...
  7. Ivanov V, Hei T. Induction of apoptotic death and retardation of neuronal differentiation of human neural stem cells by sodium arsenite treatment. Exp Cell Res. 2013;319:875-87 pubmed publisher
    ..Sodium arsenite also negatively affects neuronal differentiation of NSC through overactivation of MEK-ERK and suppression of PI3K-AKT...
  8. Carpenter R, Jiang Y, Jing Y, He J, Rojanasakul Y, Liu L, et al. Arsenite induces cell transformation by reactive oxygen species, AKT, ERK1/2, and p70S6K1. Biochem Biophys Res Commun. 2011;414:533-8 pubmed publisher
    ..These results indicate cell transformation induced by chronic arsenic exposure is mediated by increased cellular levels of ROS, which mediates activation of AKT, ERK1/2, and p70S6K1...
  9. Liu G, Liu M, Kim E, Maaty W, Bothner B, Lei B, et al. A periplasmic arsenite-binding protein involved in regulating arsenite oxidation. Environ Microbiol. 2012;14:1624-34 pubmed publisher
    ..The discovery and characterization of AioX illustrates a novel AsIII sensing mechanism that appears to be used in a range of bacteria and also provides one of the first examples of a bacterial signal anchor protein...

More Information

Publications74

  1. Ebert F, Weiss A, Bültemeyer M, Hamann I, Hartwig A, Schwerdtle T. Arsenicals affect base excision repair by several mechanisms. Mutat Res. 2011;715:32-41 pubmed publisher
  2. Ling M, Li Y, Xu Y, Pang Y, Shen L, Jiang R, et al. Regulation of miRNA-21 by reactive oxygen species-activated ERK/NF-?B in arsenite-induced cell transformation. Free Radic Biol Med. 2012;52:1508-18 pubmed publisher
    ..Thus, the transformation of HELF cells induced by chronic exposure to arsenite is mediated by increased miR-21 expression, which, in turn, is mediated by reactive oxygen species activation of the ERK/NF-?B pathway...
  3. Bornhorst J, Ebert F, Lohren H, Humpf H, Karst U, Schwerdtle T. Effects of manganese and arsenic species on the level of energy related nucleotides in human cells. Metallomics. 2012;4:297-306 pubmed publisher
  4. Li Y, Shen L, Xu H, Pang Y, Xu Y, Ling M, et al. Up-regulation of cyclin D1 by JNK1/c-Jun is involved in tumorigenesis of human embryo lung fibroblast cells induced by a low concentration of arsenite. Toxicol Lett. 2011;206:113-20 pubmed publisher
    ..Thus, activation of the JNK1/c-Jun pathway up-regulates the expression of cyclin D1, which is involved in the tumorigenesis caused by a low concentration of arsenite...
  5. Leffers L, Unterberg M, Bartel M, Hoppe C, Pieper I, Stertmann J, et al. In vitro toxicological characterisation of the S-containing arsenic metabolites thio-dimethylarsinic acid and dimethylarsinic glutathione. Toxicology. 2013;305:109-19 pubmed publisher
    ..Since in vivo RONS are permanently endogenously and exogenously produced, this boost of the existing oxidative stress by arsenite and thio-DMA(V) might contribute to the process of inorganic arsenic induced carcinogenicity...
  6. Khan S, Vala J, Nabi S, Gupta G, Kumar D, Telang A, et al. Protective effect of curcumin against arsenic-induced apoptosis in murine splenocytes in vitro. J Immunotoxicol. 2012;9:148-59 pubmed publisher
  7. Tan M, Schmidt R, Beier J, Watson W, Zhong H, States J, et al. Chronic subhepatotoxic exposure to arsenic enhances hepatic injury caused by high fat diet in mice. Toxicol Appl Pharmacol. 2011;257:356-64 pubmed publisher
    ..These data indicate that subhepatotoxic arsenic exposure enhances the toxicity of HFD. These results also suggest that arsenic exposure might be a risk factor for the development of fatty liver disease in human populations...
  8. Keim A, Rössler O, Rothhaar T, Thiel G. Arsenite-induced apoptosis of human neuroblastoma cells requires p53 but occurs independently of c-Jun. Neuroscience. 2012;206:25-38 pubmed publisher
    ..Together, these data show that the upregulation of p53 is causally linked with arsenite-induced cell death in neuroblastoma cells, whereas the upregulation of c-Jun is not part of this apoptotic signaling cascade...
  9. Calatayud M, Devesa V, Montoro R, Velez D. In vitro study of intestinal transport of arsenite, monomethylarsonous acid, and dimethylarsinous acid by Caco-2 cell line. Toxicol Lett. 2011;204:127-33 pubmed publisher
    ..Variations in pH do not affect transport of these species. The presence of GSH and green tea extract significantly alters transport of As(III) across Caco-2 cells...
  10. Vujcic M, Shroff M, Singh K. Genetic determinants of mitochondrial response to arsenic in yeast Saccharomyces cerevisiae. Cancer Res. 2007;67:9740-9 pubmed
    ..cerevisiae from arsenic-induced toxicity. Together, our studies suggest that evolutionary conserved mitochondrial networks identified in yeast S. cerevisiae must play an important role in arsenic-induced carcinogenesis in humans. ..
  11. Yu X, Robinson J, Gribble E, Hong S, Sidhu J, Faustman E. Gene expression profiling analysis reveals arsenic-induced cell cycle arrest and apoptosis in p53-proficient and p53-deficient cells through differential gene pathways. Toxicol Appl Pharmacol. 2008;233:389-403 pubmed publisher
  12. Nemeti B, Gregus Z. Mechanism of thiol-supported arsenate reduction mediated by phosphorolytic-arsenolytic enzymes: I. The role of arsenolysis. Toxicol Sci. 2009;110:270-81 pubmed publisher
    ..This hypothesis is evaluated in the adjoining paper. ..
  13. Quéméneur M, Cébron A, Billard P, Battaglia Brunet F, Garrido F, Leyval C, et al. Population structure and abundance of arsenite-oxidizing bacteria along an arsenic pollution gradient in waters of the upper isle River Basin, France. Appl Environ Microbiol. 2010;76:4566-70 pubmed publisher
    ..The highest aoxB gene densities were found in the most As-polluted oxic surface waters but without any significant correlation with environmental factors. Arsenite oxidizers seem to play a key role in As mobility in As-impacted waters. ..
  14. Ma J, Yamaji N, Mitani N, Xu X, Su Y, McGrath S, et al. Transporters of arsenite in rice and their role in arsenic accumulation in rice grain. Proc Natl Acad Sci U S A. 2008;105:9931-5 pubmed publisher
    ..Our results provide insight into the uptake mechanism of arsenite in rice and strategies for reducing arsenic accumulation in grain for enhanced food safety. ..
  15. Stone R. Food safety. Arsenic and paddy rice: a neglected cancer risk?. Science. 2008;321:184-5 pubmed publisher
  16. Cai L, Liu G, Rensing C, Wang G. Genes involved in arsenic transformation and resistance associated with different levels of arsenic-contaminated soils. BMC Microbiol. 2009;9:4 pubmed publisher
    ..Bacteria capable of both arsenite oxidation and arsenite efflux mechanisms had an elevated arsenite resistance level. ..
  17. Nollen M, Ebert F, Moser J, Mullenders L, Hartwig A, Schwerdtle T. Impact of arsenic on nucleotide excision repair: XPC function, protein level, and gene expression. Mol Nutr Food Res. 2009;53:572-82 pubmed publisher
    ..In summary, our data demonstrate that in human skin fibroblasts arsenite and even more pronounced MMA(III) interact with XPC expression, resulting in decreased XPC protein level and diminished assembly of the NER machinery. ..
  18. Migdal I, Ilina Y, Tamás M, Wysocki R. Mitogen-activated protein kinase Hog1 mediates adaptation to G1 checkpoint arrest during arsenite and hyperosmotic stress. Eukaryot Cell. 2008;7:1309-17 pubmed publisher
    ..Taken together, our data point to an important role of the Hog1 kinase in adaptation to stress-induced G(1) cell cycle arrest. ..
  19. Quéméneur M, Heinrich Salmeron A, Muller D, Lièvremont D, Jauzein M, Bertin P, et al. Diversity surveys and evolutionary relationships of aoxB genes in aerobic arsenite-oxidizing bacteria. Appl Environ Microbiol. 2008;74:4567-73 pubmed publisher
    ..Our study underlines the usefulness of the aoxB gene as a functional marker of aerobic As(III) oxidizers. ..
  20. Tokar E, Diwan B, Waalkes M. Arsenic exposure transforms human epithelial stem/progenitor cells into a cancer stem-like phenotype. Environ Health Perspect. 2010;118:108-15 pubmed publisher
    ..However, proof of emergence of CSCs induced by arsenic in a stem cell population is not available...
  21. Wen G, Calaf G, Partridge M, Echiburu Chau C, Zhao Y, Huang S, et al. Neoplastic transformation of human small airway epithelial cells induced by arsenic. Mol Med. 2008;14:2-10 pubmed
    ..Taken together, these results strongly suggest that h-TERT immortalized human small airway epithelial cells underwent step-wise transformation after inorganic arsenic treatment...
  22. Oremland R, Stolz J, Hollibaugh J. The microbial arsenic cycle in Mono Lake, California. FEMS Microbiol Ecol. 2004;48:15-27 pubmed publisher
  23. Liu W, Wood B, Raab A, McGrath S, Zhao F, Feldmann J. Complexation of arsenite with phytochelatins reduces arsenite efflux and translocation from roots to shoots in Arabidopsis. Plant Physiol. 2010;152:2211-21 pubmed publisher
    ..Enhancing PC synthesis in roots may be an effective strategy to reduce As translocation to the edible organs of food crops...
  24. Li Y, Ling M, Xu Y, Wang S, Li Z, Zhou J, et al. The repressive effect of NF-kappaB on p53 by mot-2 is involved in human keratinocyte transformation induced by low levels of arsenite. Toxicol Sci. 2010;116:174-82 pubmed publisher
    ..Together, the results suggest that the repressive effect of NF-kappaB on p53 by mot-2 leads to genomic instability, which is involved in arsenite-induced malignant transformation of human keratinocytes...
  25. Yuan C, Lu X, Oro N, Wang Z, Xia Y, Wade T, et al. Arsenic speciation analysis in human saliva. Clin Chem. 2008;54:163-71 pubmed
    ..Determination of arsenic species in saliva is potentially useful for biomonitoring of human exposure and studying arsenic metabolism. Arsenic speciation in saliva has not been reported previously...
  26. Li G, Lee L, Li M, Tsao S, Chiu J. Molecular changes during arsenic-induced cell transformation. J Cell Physiol. 2011;226:3225-32 pubmed publisher
    ..Our experimental results clearly demonstrated that induction of p-ERK and cell proliferation by arsenite is mediated via oxidative stress, since antioxidants can inhibit arsenite-induced cell transformation...
  27. Nicolis I, Curis E, Deschamps P, Benazeth S. Arsenite medicinal use, metabolism, pharmacokinetics and monitoring in human hair. Biochimie. 2009;91:1260-7 pubmed publisher
    ..Micro-XANES spectra recorded at the periphery of hair, suggest that inorganic arsenic is incorporated in hair in its trivalent oxidation state, in agreement with previous results...
  28. Pepi M, Volterrani M, Renzi M, Marvasi M, Gasperini S, Franchi E, et al. Arsenic-resistant bacteria isolated from contaminated sediments of the Orbetello Lagoon, Italy, and their characterization. J Appl Microbiol. 2007;103:2299-308 pubmed
    ..The aim of this study was to isolate arsenic-resistant bacteria from contaminated sediment of the Orbetello Lagoon, Italy, to characterize isolates for As(III), As(V), heavy metals resistance, and from the phylogenetic point of view...
  29. Ohn T, Kedersha N, Hickman T, Tisdale S, Anderson P. A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly. Nat Cell Biol. 2008;10:1224-31 pubmed publisher
    ..The lack of enzymes of the hexosamine biosynthetic pathway in budding yeast may contribute to differences between mammalian SGs and related yeast EGP (eIF4E, 4G and Pab1 containing) bodies...
  30. Xu X, McGrath S, Zhao F. Rapid reduction of arsenate in the medium mediated by plant roots. New Phytol. 2007;176:590-9 pubmed
    ..Tomato and rice roots rapidly reduce arsenate to arsenite, some of which is actively effluxed to the medium. The study reveals a new aspect of As metabolism in plants...
  31. Xu X, McGrath S, Meharg A, Zhao F. Growing rice aerobically markedly decreases arsenic accumulation. Environ Sci Technol. 2008;42:5574-9 pubmed
  32. Liao V, Chu Y, Su Y, Hsiao S, Wei C, Liu C, et al. Arsenite-oxidizing and arsenate-reducing bacteria associated with arsenic-rich groundwater in Taiwan. J Contam Hydrol. 2011;123:20-9 pubmed publisher
    ..Our results further support the hypothesis that bacteria capable of either oxidizing arsenite or reducing arsenate coexist and are ubiquitous in arsenic-contaminated groundwater...
  33. Gao M, Dong W, Hu M, Yu M, Guo L, Qian L, et al. GADD45alpha mediates arsenite-induced cell apoptotic effect in human hepatoma cells via JNKs/AP-1-dependent pathway. J Cell Biochem. 2010;109:1264-73 pubmed publisher
    ..The approaches to up-regulate GADD45alpha levels might be helpful in improving the chemotherapeutic action of arsenite on certain solid tumors including hepatoma...
  34. Liao V, Liu J, Li W, Yu C, Hsieh Y. Caenorhabditis elegans bicarbonate transporter ABTS-1 is involved in arsenite toxicity and cholinergic signaling. Chem Res Toxicol. 2010;23:926-32 pubmed publisher
    ..We also showed that arsenite enhanced sensitivity to aldicarb and levamisole in abts-1 mutant worms. Our results indicate neuronal effects of arsenite and the ABTS-1 bicarbonate transporter...
  35. Zhang D, Li J, Gao J, Huang C. c-Jun/AP-1 pathway-mediated cyclin D1 expression participates in low dose arsenite-induced transformation in mouse epidermal JB6 Cl41 cells. Toxicol Appl Pharmacol. 2009;235:18-24 pubmed publisher
    ..Collectively, our results demonstrate that c-Jun/AP-1-mediated cyclin D1 expression is at least one of the key events implicated in cell transformation upon low dose arsenite exposure...
  36. Nohara K, Baba T, Murai H, Kobayashi Y, Suzuki T, Tateishi Y, et al. Global DNA methylation in the mouse liver is affected by methyl deficiency and arsenic in a sex-dependent manner. Arch Toxicol. 2011;85:653-61 pubmed publisher
    ..The sex-dependent changes in 5meC content induced by methyl deficiency and arsenic may be involved in differences in male and female susceptibility to diseases via epigenetic modification of physiological functions...
  37. Kamiya T, Tanaka M, Mitani N, Ma J, Maeshima M, Fujiwara T. NIP1;1, an aquaporin homolog, determines the arsenite sensitivity of Arabidopsis thaliana. J Biol Chem. 2009;284:2114-20 pubmed publisher
    ..This indicates that As(III) tolerance cannot be simply explained by decreased As contents in plants...
  38. Su Y, McGrath S, Zhu Y, Zhao F. Highly efficient xylem transport of arsenite in the arsenic hyperaccumulator Pteris vittata. New Phytol. 2008;180:434-41 pubmed publisher
    ..vittata. Arsenite is highly mobile in xylem transport, possibly because of efficient xylem loading, little complexation with thiols in roots, and little efflux to the external medium...
  39. Ghatak S, Biswas A, Dhali G, Chowdhury A, Boyer J, Santra A. Oxidative stress and hepatic stellate cell activation are key events in arsenic induced liver fibrosis in mice. Toxicol Appl Pharmacol. 2011;251:59-69 pubmed publisher
    ..These findings have implications not only for the understanding of the pathology of arsenic related liver fibrosis but also for the design of preventive strategies in chronic arsenicosis...
  40. Duquesne K, Lieutaud A, Ratouchniak J, Muller D, Lett M, Bonnefoy V. Arsenite oxidation by a chemoautotrophic moderately acidophilic Thiomonas sp.: from the strain isolation to the gene study. Environ Microbiol. 2008;10:228-37 pubmed
    ..The expression of this operon is greater in cells grown in the presence than in the absence of arsenite, in agreement with a transcriptional regulation in the presence of this metalloid...
  41. Kolobova E, Efimov A, Kaverina I, Rishi A, Schrader J, Ham A, et al. Microtubule-dependent association of AKAP350A and CCAR1 with RNA stress granules. Exp Cell Res. 2009;315:542-55 pubmed publisher
    ..These results provide the first evidence for the microtubule dependent association of AKAP350A and CCAR1 with RNA stress granules...
  42. Gregus Z, Roos G, Geerlings P, Nemeti B. Mechanism of thiol-supported arsenate reduction mediated by phosphorolytic-arsenolytic enzymes: II. Enzymatic formation of arsenylated products susceptible for reduction to arsenite by thiols. Toxicol Sci. 2009;110:282-92 pubmed publisher
    ..In support of this view, reactivity studies using conceptual density functional theory reactivity descriptors (local softness, nucleofugality) indicate that reduction by thiols of the arsenylated metabolites is favored over AsV...
  43. Liao W, Lin P, Cheng T, Yu H, Chang L. Arsenic promotes centrosome abnormalities and cell colony formation in p53 compromised human lung cells. Toxicol Appl Pharmacol. 2007;225:162-70 pubmed
    ..These findings provided strong evidence on the carcinogenic promotional role of arsenic, especially under the condition of p53 dysfunction...
  44. Bryan C, Marchal M, Battaglia Brunet F, Kugler V, Lemaitre Guillier C, Lièvremont D, et al. Carbon and arsenic metabolism in Thiomonas strains: differences revealed diverse adaptation processes. BMC Microbiol. 2009;9:127 pubmed publisher
    ..Ynys1 and T. perometabolis are not. Moreover, T. arsenivorans and 3As present interesting physiological traits, in particular that these strains are able to use As(III) as an electron donor...
  45. Ouyang W, Luo W, Zhang D, Jian J, Ma Q, Li J, et al. PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation. Environ Health Perspect. 2008;116:1-6 pubmed publisher
    ..Long-term exposure of arsenite leads to human skin cancer. However, the exact mechanisms of arsenite-induced human skin carcinogenesis remain to be defined...
  46. Chang J, Yoon I, Kim K. Isolation and ars detoxification of arsenite-oxidizing bacteria from abandoned arsenic-contaminated mines. J Microbiol Biotechnol. 2007;17:812-21 pubmed
    ..Accordingly, the present results suggest that arsR, arsD, arsAB, arsA, arsB, arsC, arsH, arrA, arrB, aoxA, aoxB, aoxC, aoxD, aroA, and aroB may be useful for arsenite-oxidizing bacteria in abandoned arsenic-contaminated mines...
  47. Indriolo E, Na G, Ellis D, Salt D, Banks J. A vacuolar arsenite transporter necessary for arsenic tolerance in the arsenic hyperaccumulating fern Pteris vittata is missing in flowering plants. Plant Cell. 2010;22:2045-57 pubmed publisher
    ..The duplication of ACR3 in P. vittata and the loss of ACR3 in angiosperms may explain arsenic tolerance in this unusual group of ferns while precluding the same trait in angiosperms...
  48. Pi J, Diwan B, Sun Y, Liu J, Qu W, He Y, et al. Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2. Free Radic Biol Med. 2008;45:651-8 pubmed publisher
  49. Mollet S, Cougot N, Wilczynska A, Dautry F, Kress M, Bertrand E, et al. Translationally repressed mRNA transiently cycles through stress granules during stress. Mol Biol Cell. 2008;19:4469-79 pubmed publisher
    ..Accordingly, most arrested mRNAs are located outside stress granules. Overall, these kinetic data do not support a direct role of stress granules neither as storage site nor as intermediate location before degradation...
  50. Sardiwal S, Santini J, Osborne T, Djordjevic S. Characterization of a two-component signal transduction system that controls arsenite oxidation in the chemolithoautotroph NT-26. FEMS Microbiol Lett. 2010;313:20-8 pubmed publisher
    ..Lastly, arsenite sensing does not appear to involve thiol chemistry...
  51. Oliveira R, Porter Abate J, Dilks K, Landis J, Ashraf J, Murphy C, et al. Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf. Aging Cell. 2009;8:524-41 pubmed publisher
    ..In response to stress, SKN-1 and other regulators tailor transcription programs to meet the challenge at hand. Our findings reveal striking complexity in SKN-1 functions and the regulation of systemic detoxification defenses. ..
  52. Weiss S, Carapito C, Cleiss J, Koechler S, Turlin E, Coppee J, et al. Enhanced structural and functional genome elucidation of the arsenite-oxidizing strain Herminiimonas arsenicoxydans by proteomics data. Biochimie. 2009;91:192-203 pubmed publisher
    ..This study provides therefore new insights into the adaptation processes of H. arsenicoxydans in response to arsenic...
  53. Nemeti B, Regonesi M, Tortora P, Gregus Z. Polynucleotide phosphorylase and mitochondrial ATP synthase mediate reduction of arsenate to the more toxic arsenite by forming arsenylated analogues of ADP and ATP. Toxicol Sci. 2010;117:270-81 pubmed publisher
    ..Thus, whereas PNPase promotes reduction of AsV by incorporating it into AMP-AsV, the mitochondrial ATP synthase facilitates AsV reduction by forming ADP-AsV; then GSH can easily reduce these arsenylated nucleotides to AsIII...
  54. Zhang Y, Monchy S, Greenberg B, Mergeay M, Gang O, Taghavi S, et al. ArsR arsenic-resistance regulatory protein from Cupriavidus metallidurans CH34. Antonie Van Leeuwenhoek. 2009;96:161-70 pubmed publisher
  55. Suzuki S, Arnold L, Pennington K, Chen B, Naranmandura H, Le X, et al. Dietary administration of sodium arsenite to rats: relations between dose and urinary concentrations of methylated and thio-metabolites and effects on the rat urinary bladder epithelium. Toxicol Appl Pharmacol. 2010;244:99-105 pubmed publisher
    ..These data suggest that dietary As(III)-induced urothelial cytotoxicity and proliferation are dose responsive, and the urothelial effects have a threshold corresponding to the urinary excretion of measurable reactive metabolites...
  56. Wang X, Sun Z, Chen W, Eblin K, Gandolfi J, Zhang D. Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity. Toxicol Appl Pharmacol. 2007;225:206-13 pubmed
    ..The current work lays the groundwork for using Nrf2 activators for therapeutic and dietary interventions against adverse effects of arsenic...
  57. Kim J, Lee J, Kim J, Gardner D, Beachy P. Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proc Natl Acad Sci U S A. 2010;107:13432-7 pubmed publisher
  58. Druwe I, Vaillancourt R. Influence of arsenate and arsenite on signal transduction pathways: an update. Arch Toxicol. 2010;84:585-96 pubmed publisher
    ..However, given the ubiquitous nature of arsenic in the environment, making sense of all the data remains a challenge. This review will focus on our knowledge of signal transduction pathways that are regulated by arsenic...
  59. Marchal M, Briandet R, Koechler S, Kammerer B, Bertin P. Effect of arsenite on swimming motility delays surface colonization in Herminiimonas arsenicoxydans. Microbiology. 2010;156:2336-42 pubmed publisher
    ..Our study therefore highlights the existence, under arsenite exposure, of a competition between swimming motility, resulting from arsenite oxidation, and biofilm initiation...
  60. Koechler S, Cleiss Arnold J, Proux C, Sismeiro O, Dillies M, Goulhen Chollet F, et al. Multiple controls affect arsenite oxidase gene expression in Herminiimonas arsenicoxydans. BMC Microbiol. 2010;10:53 pubmed publisher
    ..Herminiimonas arsenicoxydans has been isolated from an arsenic- contaminated environment and has developed various mechanisms for coping with arsenic, including the oxidation of As(III) to As(V) as a detoxification mechanism...
  61. Murphy J, Saltikov C. The ArsR repressor mediates arsenite-dependent regulation of arsenate respiration and detoxification operons of Shewanella sp. strain ANA-3. J Bacteriol. 2009;191:6722-31 pubmed publisher
    ..strain ANA-3. However, anaerobic growth on arsenate will require coregulation with global regulators such as cAMP-CRP...
  62. Cassola A, Frasch A. An RNA recognition motif mediates the nucleocytoplasmic transport of a trypanosome RNA-binding protein. J Biol Chem. 2009;284:35015-28 pubmed publisher
    ..We propose that TcUBP1 could be linking the mRNA metabolism at both sides of the nuclear pore complex, using the RRM as a nuclear localization signal, and being exported as a cargo on mRNA...
  63. Naranmandura H, Ogra Y, Iwata K, Lee J, Suzuki K, Weinfeld M, et al. Evidence for toxicity differences between inorganic arsenite and thioarsenicals in human bladder cancer cells. Toxicol Appl Pharmacol. 2009;238:133-40 pubmed publisher
    ..In A431 cells, only mRNA and protein of AQP3 were detected. The large difference in toxicity between the two cell lines could be related to their differences in uptake of arsenic species...
  64. Ding W, Liu W, Cooper K, Qin X, de Souza Bergo P, Hudson L, et al. Inhibition of poly(ADP-ribose) polymerase-1 by arsenite interferes with repair of oxidative DNA damage. J Biol Chem. 2009;284:6809-17 pubmed publisher
    ..Arsenite inhibition of poly(ADP-ribosyl)ation is one likely mechanism for the reported co-carcinogenic activities of arsenic in UVR-induced skin carcinogenesis...
  65. Nemeti B, Gregus Z. Glutathione-dependent reduction of arsenate by glycogen phosphorylase a reaction coupled to glycogenolysis. Toxicol Sci. 2007;100:36-43 pubmed
    ..While its in vivo significance remains to be tested, further characterization of the GP-catalyzed As(V) reduction is presented in the adjoining paper...